Serine/threonine-protein kinase atr

Overview


Name	Serine/threonine-protein kinase atr
Smed ID	SMED30009778
Length (bp)	823

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Serine/threonine-protein kinase atr (SMED30009778) t-SNE clustered cells

Violin plots show distribution of expression levels for Serine/threonine-protein kinase atr (SMED30009778) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Serine/threonine-protein kinase atr (SMED30009778) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Serine/threonine-protein kinase atr (SMED30009778) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30009778

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
X1 cell	SMED30009778	SMESG000018015.1 SMESG000018013.1	SmedASXL_017725	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
zeta neoblast	SMED30009778	SMESG000018015.1 SMESG000018013.1	dd_Smed_v4_8754_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Human
Match: ATR (ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882])

HSP 1 Score: 235.343 bits (599), Expect = 8.325e-70
Identity = 117/243 (48.15%), Postives = 158/243 (65.02%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK----QSNAVTMTENKLE--EMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            GK     M      L +KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V K   +D L E   P+   +K    ++  V   + K    ++E RL+G      +V  LPLS+EG V+YLI +A DE LLCQMY+GW  ++
Sbjct: 2339 GKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 2580

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Human
Match: ATR (ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882])

HSP 1 Score: 235.343 bits (599), Expect = 8.586e-70
Identity = 117/243 (48.15%), Postives = 158/243 (65.02%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK----QSNAVTMTENKLE--EMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            GK     M      L +KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V K   +D L E   P+   +K    ++  V   + K    ++E RL+G      +V  LPLS+EG V+YLI +A DE LLCQMY+GW  ++
Sbjct: 2403 GKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 2644

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Human
Match: ATR (ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882])

HSP 1 Score: 190.66 bits (483), Expect = 2.852e-54
Identity = 88/168 (52.38%), Postives = 115/168 (68.45%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPL 601
            GK     M      L +KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V K   +D L E   P+
Sbjct: 2000 GKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPV 2166

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Human
Match: ATM (ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795])

HSP 1 Score: 146.362 bits (368), Expect = 5.855e-39
Identity = 85/229 (37.12%), Postives = 126/229 (55.02%), Query Frame = 2

Query:  194 VFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTL--------------------TEVKDPLIKSNKQSNAVTMTE-----NKLEE-----MENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            VF  + ++KF +P  W+     Y RSVA  S+VGYILGLGDRH++NIL +  S ++VHID    F  GK L  PE VPFRLTR++ DG+G  G   G+FR  C  T+ ++RN  E ++ + + + YD L                    TE+  P + ++ Q     +++     NK+ E     ++ +LKG      LSV G+VN LI QAID K L +++ GW +++
Sbjct: 2830 VFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGV-EGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELH-PTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056

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Query:  194 VFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTL--------------------TEVKDPLIKSNKQSNAVTMTE-----NKLEE-----MENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            VF  + ++KF +P  W+     Y RSVA  S+VGYILGLGDRH++NIL +  S ++VHID    F  GK L  PE VPFRLTR++ DG+G  G   G+FR  C  T+ ++RN  E ++ + + + YD L                    TE+  P + ++ Q     +++     NK+ E     ++ +LKG      LSV G+VN LI QAID K L +++ GW +++
Sbjct: 2830 VFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGV-EGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELH-PTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Celegans
Match: atl-1 (Serine/threonine-protein kinase ATR [Source:UniProtKB/Swiss-Prot;Acc:Q22258])

HSP 1 Score: 134.035 bits (336), Expect = 3.581e-35
Identity = 82/227 (36.12%), Postives = 125/227 (55.07%), Query Frame = 2

Query:  143 KKKLMKFTKEV-LPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRN---EIEPIMAVFKPMYYDTLTEVKDPLIKSNKQS-NAVTMTENKLEEMENRLKGKVNQL----------PLSVEGEVNYLIAQAIDEKLLCQMYMGW 778
            K++  K+ +EV     PVV  KWF  ++PE   W+ S + + +S AVMS++GYI GLGDRH +N++  HT+G  +H+D++ +FN G+TL  PE+VPFRLT+NM +G+G     +G FR+ C   L + R    EIE  +A    +  D           SNK++     M+E K   +  RL+G++             P+ V    + LI  A  E+ L +MY+GW
Sbjct:  839 KEERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMV-HTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVAL-DGEFRTVCEQALRVFRENSYEIEKYIADLPNLVAD---------FPSNKRAPKDFDMSEAK-RLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLIELATSEEKLSEMYLGW 1053

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Celegans
Match: atl-1 (Serine/threonine-protein kinase ATR [Source:UniProtKB/Swiss-Prot;Acc:Q22258])

HSP 1 Score: 134.035 bits (336), Expect = 3.955e-35
Identity = 78/211 (36.97%), Postives = 117/211 (55.45%), Query Frame = 2

Query:  188 PVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRN---EIEPIMAVFKPMYYDTLTEVKDPLIKSNKQS-NAVTMTENKLEEMENRLKGKVNQL----------PLSVEGEVNYLIAQAIDEKLLCQMYMGW 778
            PVV  KWF  ++PE   W+ S + + +S AVMS++GYI GLGDRH +N++  HT+G  +H+D++ +FN G+TL  PE+VPFRLT+NM +G+G     +G FR+ C   L + R    EIE  +A    +  D           SNK++     M+E K   +  RL+G++             P+ V    + LI  A  E+ L +MY+GW
Sbjct: 2312 PVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMV-HTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVAL-DGEFRTVCEQALRVFRENSYEIEKYIADLPNLVAD---------FPSNKRAPKDFDMSEAK-RLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLIELATSEEKLSEMYLGW 2510

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Celegans
Match: atl-1 (Serine/threonine-protein kinase ATR [Source:UniProtKB/Swiss-Prot;Acc:Q22258])

HSP 1 Score: 134.035 bits (336), Expect = 3.955e-35
Identity = 78/211 (36.97%), Postives = 117/211 (55.45%), Query Frame = 2

Query:  188 PVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRN---EIEPIMAVFKPMYYDTLTEVKDPLIKSNKQS-NAVTMTENKLEEMENRLKGKVNQL----------PLSVEGEVNYLIAQAIDEKLLCQMYMGW 778
            PVV  KWF  ++PE   W+ S + + +S AVMS++GYI GLGDRH +N++  HT+G  +H+D++ +FN G+TL  PE+VPFRLT+NM +G+G     +G FR+ C   L + R    EIE  +A    +  D           SNK++     M+E K   +  RL+G++             P+ V    + LI  A  E+ L +MY+GW
Sbjct: 2312 PVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMV-HTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVAL-DGEFRTVCEQALRVFRENSYEIEKYIADLPNLVAD---------FPSNKRAPKDFDMSEAK-RLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLIELATSEEKLSEMYLGW 2510

[Close]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Celegans
Match: atl-1 (Serine/threonine-protein kinase ATR [Source:UniProtKB/Swiss-Prot;Acc:Q22258])

HSP 1 Score: 134.035 bits (336), Expect = 4.112e-35
Identity = 78/211 (36.97%), Postives = 117/211 (55.45%), Query Frame = 2

Query:  188 PVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRN---EIEPIMAVFKPMYYDTLTEVKDPLIKSNKQS-NAVTMTENKLEEMENRLKGKVNQL----------PLSVEGEVNYLIAQAIDEKLLCQMYMGW 778
            PVV  KWF  ++PE   W+ S + + +S AVMS++GYI GLGDRH +N++  HT+G  +H+D++ +FN G+TL  PE+VPFRLT+NM +G+G     +G FR+ C   L + R    EIE  +A    +  D           SNK++     M+E K   +  RL+G++             P+ V    + LI  A  E+ L +MY+GW
Sbjct: 2329 PVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMV-HTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVAL-DGEFRTVCEQALRVFRENSYEIEKYIADLPNLVAD---------FPSNKRAPKDFDMSEAK-RLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLIELATSEEKLSEMYLGW 2527

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Celegans
Match: smg-1 (Serine/threonine-protein kinase smg-1 [Source:UniProtKB/Swiss-Prot;Acc:O01510])

HSP 1 Score: 123.25 bits (308), Expect = 2.016e-31
Identity = 59/120 (49.17%), Postives = 77/120 (64.17%), Query Frame = 2

Query:  227 EPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
            +   W+   ++Y RS+AVMSMVG +LGLGDRH++N+L D   G VVHIDYN  F+ GK L  PE VPFRLTRNM+  LGP  E  G FR SCV  L+ LR+  + +  +     +D L +
Sbjct: 1937 DATTWWSVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPETVPFRLTRNMRHALGP-SEMYGTFRESCVHVLSTLRSGHQVLTMLLDAFVFDPLVD 2055

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Fly
Match: mei-41 (gene:FBgn0004367 transcript:FBtr0074271)

HSP 1 Score: 203.371 bits (516), Expect = 4.587e-59
Identity = 101/235 (42.98%), Postives = 144/235 (61.28%), Query Frame = 2

Query:  101 KSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKV-----NQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            +S  + +H  +   ++K   FTK+++P +P VF +W  Q+F  P++WY +   Y R+VAVMSMVGYILGLGDRH ENILF   +GD VH+D+N LFN G+ L +PEVVPFRLT NM   +GP G   G FR  C  TL LL+ E + +M++ +P  YD   +         ++  A       ++ + +RL+G V     N +PLS EG+VN+LI +A     L  MY+GWG+F+
Sbjct: 2295 QSLAVPLHESI---ERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLG-VEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQ--------TRKGAATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAFL 2517

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Fly
Match: tefu (gene:FBgn0045035 transcript:FBtr0110874)

HSP 1 Score: 135.576 bits (340), Expect = 1.651e-35
Identity = 77/206 (37.38%), Postives = 107/206 (51.94%), Query Frame = 2

Query:  194 VFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYD------TLTEVKDPLIKSNKQSN-----AVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGW 778
            VF+ + L+KFP P  W+     Y  SVA  SMVGY+LGLGDRH +NIL D  + +V+HID+   F  GK    PE VPFRLTR+    +G CG   G+F  SC AT+++LR        + + + YD       L + + P     +  N     A+ + +NKL+  E    G  N     VE +V  LI +A     LC ++ GW
Sbjct: 2564 VFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICG-TKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQSPQQSGEESVNLVAQRALLLVQNKLDGREAGTMGDSN-----VEAQVERLINEATLPSNLCMLFPGW 2763

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Fly
Match: nonC (gene:FBgn0263968 transcript:FBtr0070972)

HSP 1 Score: 119.013 bits (297), Expect = 8.789e-30
Identity = 53/116 (45.69%), Postives = 78/116 (67.24%), Query Frame = 2

Query:  239 WYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
            W +SV+++ R ++VMSM+GY++GLGDRH++N+L +  SGD+VHIDYN  F  G+TL  PE VPFRLT+N+   +G  G   G FR  C   L ++R E E ++ + +   YD L +
Sbjct: 2079 WRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGI-EGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVD 2193

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Fly
Match: nonC (gene:FBgn0263968 transcript:FBtr0343321)

HSP 1 Score: 119.013 bits (297), Expect = 8.789e-30
Identity = 53/116 (45.69%), Postives = 78/116 (67.24%), Query Frame = 2

Query:  239 WYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
            W +SV+++ R ++VMSM+GY++GLGDRH++N+L +  SGD+VHIDYN  F  G+TL  PE VPFRLT+N+   +G  G   G FR  C   L ++R E E ++ + +   YD L +
Sbjct: 2079 WRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGI-EGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVD 2193

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Fly
Match: Tor (gene:FBgn0021796 transcript:FBtr0336615)

HSP 1 Score: 111.694 bits (278), Expect = 2.420e-27
Identity = 77/244 (31.56%), Postives = 107/244 (43.85%), Query Frame = 2

Query:  218 KFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLE-WPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTL-----------------------------------TEVKD--PLIKSNK----------QSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVN------YLIAQAIDEKLLCQMYMGWGSF 787
            K P    W+     Y RS+AVMSMVGYILGLGDRH  N++ D  SG ++HID+   F    T E +PE +PFRLTR +   +   G   G +R +C + + +LR   + +MAV +   YD L                                     V+D  P+ KS             +N    T +K  ++  R+K K+       E  VN       LI QA + + LCQ Y+GW  F
Sbjct: 2228 KSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTG-IEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPF 2470

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Zebrafish
Match: atr (ATR serine/threonine kinase [Source:ZFIN;Acc:ZDB-GENE-070912-458])

HSP 1 Score: 222.246 bits (565), Expect = 1.788e-65
Identity = 112/225 (49.78%), Postives = 150/225 (66.67%), Query Frame = 2

Query:  155 MKFTKEVL-PLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK----QSNAVTMTENKLE--EMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            +K  K+VL   +P VF++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T + PEVVPFRLT+NM   +GP G   GLFR +C   L L+R++ EP+M+V K   +D L E   P+   +K    +S  +   + K    ++E RL+G      KV  LPLS+EG V+YLI +A D+ LLC MY+GWG ++
Sbjct: 2412 LKLHKDVLCARHPPVFHEWFLRTFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFDVPEVVPFRLTQNMVHAMGPMG-TEGLFRQACEVILRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGFSKTQVNESGEILNEKAKTHVLDIEQRLQGVIKNRNKVMGLPLSIEGHVHYLIQEATDDNLLCMMYLGWGPYL 2635

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Zebrafish
Match: atm (ATM serine/threonine kinase [Source:ZFIN;Acc:ZDB-GENE-040809-1])

HSP 1 Score: 143.28 bits (360), Expect = 4.818e-38
Identity = 86/245 (35.10%), Postives = 129/245 (52.65%), Query Frame = 2

Query:  149 KLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTL----------------------------TEVKDPLIKSNKQSNAVT---MTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            KL  FT EV   +  VF  + +++F +P  W      Y RSVA  S+VGYI+GLGDRHI+NIL D  + ++VHID    F  GK L  PE VPFRL+R++ DG+G  G   G+FR  C  T+ ++R+  E ++ + + + YD L                            T   D +    K S++ +   + E  L  ++ +LKG  +   LSV G+VN LI QA+D K L +++ GW +++
Sbjct: 2849 KLQAFT-EVCQNFRPVFRYFCMERFLDPAIWLERRLAYTRSVATSSIVGYIVGLGDRHIQNILIDEQTSELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITG-VEGVFRRCCEKTMEVMRSSQEALLTIVEVLLYDPLFDWTMNPLKAFYLQQHDEQAELNATLNPTPGGDEIETHRKASDSQSFNKVAERVLLRLQEKLKGVEDGTVLSVGGQVNLLIQQAMDPKNLSRLFPGWQAWV 3091

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Zebrafish
Match: atm (ATM serine/threonine kinase [Source:ZFIN;Acc:ZDB-GENE-040809-1])

HSP 1 Score: 142.895 bits (359), Expect = 5.869e-38
Identity = 86/245 (35.10%), Postives = 129/245 (52.65%), Query Frame = 2

Query:  149 KLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTL----------------------------TEVKDPLIKSNKQSNAVT---MTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            KL  FT EV   +  VF  + +++F +P  W      Y RSVA  S+VGYI+GLGDRHI+NIL D  + ++VHID    F  GK L  PE VPFRL+R++ DG+G  G   G+FR  C  T+ ++R+  E ++ + + + YD L                            T   D +    K S++ +   + E  L  ++ +LKG  +   LSV G+VN LI QA+D K L +++ GW +++
Sbjct: 2088 KLQAFT-EVCQNFRPVFRYFCMERFLDPAIWLERRLAYTRSVATSSIVGYIVGLGDRHIQNILIDEQTSELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITG-VEGVFRRCCEKTMEVMRSSQEALLTIVEVLLYDPLFDWTMNPLKAFYLQQHDEQAELNATLNPTPGGDEIETHRKASDSQSFNKVAERVLLRLQEKLKGVEDGTVLSVGGQVNLLIQQAMDPKNLSRLFPGWQAWV 2330

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Zebrafish
Match: smg1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase [Source:ZFIN;Acc:ZDB-GENE-061013-767])

HSP 1 Score: 128.642 bits (322), Expect = 5.059e-33
Identity = 58/119 (48.74%), Postives = 79/119 (66.39%), Query Frame = 2

Query:  230 PNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
            P+ W+   Q Y RS AVMSMVGYI+GLGDRH++N+L D T+G+VVHIDYN  F  GK+L  PE VPFR+T N++  LG  G   G+FR SC   + ++R   E ++ + +   YD L +
Sbjct: 2280 PSEWWSVTQTYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTHNIETALGVTGV-EGIFRLSCEQVVQIMRRGRETLLTLLEAFVYDPLVD 2397

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Query:  230 PNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
            P+ W+   Q Y RS AVMSMVGYI+GLGDRH++N+L D T+G+VVHIDYN  F  GK+L  PE VPFR+T N++  LG  G   G+FR SC   + ++R   E ++ + +   YD L +
Sbjct: 2285 PSEWWSVTQTYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTHNIETALGVTGV-EGIFRLSCEQVVQIMRRGRETLLTLLEAFVYDPLVD 2402

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Xenopus
Match: ATR (ATR serine/threonine kinase [Source:NCBI gene;Acc:100495593])

HSP 1 Score: 234.958 bits (598), Expect = 9.706e-70
Identity = 115/229 (50.22%), Postives = 155/229 (67.69%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK-QSNAVTMTENK-----LEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            L++KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V KP  +D L E   P    +K Q N      N+     + ++E RL+G      +V  LPLS+EG V+YLI +A DE LL QMY+GW  ++
Sbjct: 2381 LQEKLKVFKEALLPRHPPLFHEWFLRTFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKPFLHDPLVEWSKPARGGSKGQVNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVKGLPLSIEGHVHYLIQEATDENLLSQMYLGWAPYM 2608

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Xenopus
Match: ATR (ATR serine/threonine kinase [Source:NCBI gene;Acc:100495593])

HSP 1 Score: 234.958 bits (598), Expect = 1.100e-69
Identity = 115/229 (50.22%), Postives = 155/229 (67.69%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK-QSNAVTMTENK-----LEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            L++KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V KP  +D L E   P    +K Q N      N+     + ++E RL+G      +V  LPLS+EG V+YLI +A DE LL QMY+GW  ++
Sbjct: 2367 LQEKLKVFKEALLPRHPPLFHEWFLRTFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKPFLHDPLVEWSKPARGGSKGQVNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVKGLPLSIEGHVHYLIQEATDENLLSQMYLGWAPYM 2594

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Xenopus
Match: ATR (ATR serine/threonine kinase [Source:NCBI gene;Acc:100495593])

HSP 1 Score: 234.958 bits (598), Expect = 1.117e-69
Identity = 115/229 (50.22%), Postives = 155/229 (67.69%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK-QSNAVTMTENK-----LEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            L++KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V KP  +D L E   P    +K Q N      N+     + ++E RL+G      +V  LPLS+EG V+YLI +A DE LL QMY+GW  ++
Sbjct: 2252 LQEKLKVFKEALLPRHPPLFHEWFLRTFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKPFLHDPLVEWSKPARGGSKGQVNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVKGLPLSIEGHVHYLIQEATDENLLSQMYLGWAPYM 2479

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Xenopus
Match: ATR (ATR serine/threonine kinase [Source:NCBI gene;Acc:100495593])

HSP 1 Score: 234.958 bits (598), Expect = 1.140e-69
Identity = 115/229 (50.22%), Postives = 155/229 (67.69%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK-QSNAVTMTENK-----LEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            L++KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V KP  +D L E   P    +K Q N      N+     + ++E RL+G      +V  LPLS+EG V+YLI +A DE LL QMY+GW  ++
Sbjct: 2294 LQEKLKVFKEALLPRHPPLFHEWFLRTFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKPFLHDPLVEWSKPARGGSKGQVNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVKGLPLSIEGHVHYLIQEATDENLLSQMYLGWAPYM 2521

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Xenopus
Match: ATR (ATR serine/threonine kinase [Source:NCBI gene;Acc:100495593])

HSP 1 Score: 234.572 bits (597), Expect = 1.268e-69
Identity = 115/229 (50.22%), Postives = 155/229 (67.69%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK-QSNAVTMTENK-----LEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            L++KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V KP  +D L E   P    +K Q N      N+     + ++E RL+G      +V  LPLS+EG V+YLI +A DE LL QMY+GW  ++
Sbjct: 2300 LQEKLKVFKEALLPRHPPLFHEWFLRTFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKPFLHDPLVEWSKPARGGSKGQVNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVKGLPLSIEGHVHYLIQEATDENLLSQMYLGWAPYM 2527

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Mouse
Match: Atr (ataxia telangiectasia and Rad3 related [Source:MGI Symbol;Acc:MGI:108028])

HSP 1 Score: 236.113 bits (601), Expect = 2.914e-70
Identity = 119/243 (48.97%), Postives = 158/243 (65.02%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK----QSNAVTMTENKLE--EMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            GK     M      L +KL  F + +LP +P VF++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  TL L+R++ EP+M+V K   +D L E   P+   +K    ++  V   + K    ++E RL+G      +V  LPLS+EG V+YLI +A DE LLCQMY+GW  ++
Sbjct: 2394 GKELRQCMLPKSAALSEKLKVFQELLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 2635

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Mouse
Match: Atr (ataxia telangiectasia and Rad3 related [Source:MGI Symbol;Acc:MGI:108028])

HSP 1 Score: 236.113 bits (601), Expect = 3.030e-70
Identity = 119/243 (48.97%), Postives = 158/243 (65.02%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK----QSNAVTMTENKLE--EMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            GK     M      L +KL  F + +LP +P VF++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  TL L+R++ EP+M+V K   +D L E   P+   +K    ++  V   + K    ++E RL+G      +V  LPLS+EG V+YLI +A DE LLCQMY+GW  ++
Sbjct: 2400 GKELRQCMLPKSAALSEKLKVFQELLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 2641

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Mouse
Match: Atm (ataxia telangiectasia mutated [Source:MGI Symbol;Acc:MGI:107202])

HSP 1 Score: 144.05 bits (362), Expect = 2.814e-38
Identity = 82/230 (35.65%), Postives = 121/230 (52.61%), Query Frame = 2

Query:  194 VFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTL-------------------------------TEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            VF  + ++KF +P  W+     Y RSVA  S+VGYILGLGDRH++NIL +  S ++VHID    F  GK L  PE VPFRL+R++ DG+G  G   G+FR  C  T+ ++R+  E ++ + + + YD L                                E K  L  +++  N V   E  L  ++ +LKG      LSV G+VN LI QA+D K L +++ GW +++
Sbjct: 2840 VFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITG-VEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDESDLHSTPNADDQECKQSLSDTDQSFNKV--AERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAMDPKNLSRLFPGWKAWV 3066

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Mouse
Match: Atm (ataxia telangiectasia mutated [Source:MGI Symbol;Acc:MGI:107202])

HSP 1 Score: 144.05 bits (362), Expect = 2.841e-38
Identity = 82/230 (35.65%), Postives = 121/230 (52.61%), Query Frame = 2

Query:  194 VFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTL-------------------------------TEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            VF  + ++KF +P  W+     Y RSVA  S+VGYILGLGDRH++NIL +  S ++VHID    F  GK L  PE VPFRL+R++ DG+G  G   G+FR  C  T+ ++R+  E ++ + + + YD L                                E K  L  +++  N V   E  L  ++ +LKG      LSV G+VN LI QA+D K L +++ GW +++
Sbjct: 2837 VFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITG-VEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDESDLHSTPNADDQECKQSLSDTDQSFNKV--AERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAMDPKNLSRLFPGWKAWV 3063

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Mouse
Match: Smg1 (SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) [Source:MGI Symbol;Acc:MGI:1919742])

HSP 1 Score: 132.88 bits (333), Expect = 1.816e-34
Identity = 65/147 (44.22%), Postives = 91/147 (61.90%), Query Frame = 2

Query:  146 KKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
            K +++   E  P  P +  K        P+ W+R  Q Y RS AVMSMVGYI+GLGDRH++N+L D T+G+VVHIDYN  F  GK+L  PE VPFR+T+N++  LG  G   G+FR SC   L+++R   E ++ + +   YD L +
Sbjct: 2279 KAVLEELMEATP--PNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGV-EGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVD 2422

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BLAST of Serine/threonine-protein kinase atr vs. UniProt/SwissProt
Match: sp|Q9JKK8|ATR_MOUSE (Serine/threonine-protein kinase ATR OS=Mus musculus OX=10090 GN=Atr PE=1 SV=2)

HSP 1 Score: 236.113 bits (601), Expect = 2.098e-69
Identity = 119/243 (48.97%), Postives = 158/243 (65.02%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK----QSNAVTMTENKLE--EMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            GK     M      L +KL  F + +LP +P VF++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  TL L+R++ EP+M+V K   +D L E   P+   +K    ++  V   + K    ++E RL+G      +V  LPLS+EG V+YLI +A DE LLCQMY+GW  ++
Sbjct: 2394 GKELRQCMLPKSAALSEKLKVFQELLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEGSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 2635

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BLAST of Serine/threonine-protein kinase atr vs. UniProt/SwissProt
Match: sp|Q13535|ATR_HUMAN (Serine/threonine-protein kinase ATR OS=Homo sapiens OX=9606 GN=ATR PE=1 SV=3)

HSP 1 Score: 235.343 bits (599), Expect = 4.123e-69
Identity = 117/243 (48.15%), Postives = 158/243 (65.02%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK----QSNAVTMTENKLE--EMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            GK     M      L +KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V K   +D L E   P+   +K    ++  V   + K    ++E RL+G      +V  LPLS+EG V+YLI +A DE LLCQMY+GW  ++
Sbjct: 2403 GKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 2644

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BLAST of Serine/threonine-protein kinase atr vs. UniProt/SwissProt
Match: sp|Q9DE14|ATR_XENLA (Serine/threonine-protein kinase atr OS=Xenopus laevis OX=8355 GN=atr PE=1 SV=2)

HSP 1 Score: 230.72 bits (587), Expect = 1.707e-67
Identity = 114/229 (49.78%), Postives = 153/229 (66.81%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK-QSNAVTMTENK-----LEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            L++KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C   + L+R + E +M+V KP  +D L E   P   S+K Q N      N+     + ++E RL+G      +V  LPLS+EG V+YLI +A DE LL QMY+GW  ++
Sbjct: 2427 LQEKLKVFKEALLPRHPPLFHEWFLRTFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVIMRLMREQRESLMSVLKPFLHDPLVEWSKPARGSSKGQVNETGEVMNEKAKTHVLDIEQRLQGVIKTRNRVKGLPLSIEGHVHYLIQEATDENLLSQMYLGWAPYM 2654

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BLAST of Serine/threonine-protein kinase atr vs. UniProt/SwissProt
Match: sp|Q9VXG8|ATR_DROME (Serine/threonine-protein kinase ATR OS=Drosophila melanogaster OX=7227 GN=mei-41 PE=1 SV=2)

HSP 1 Score: 203.371 bits (516), Expect = 4.598e-58
Identity = 101/235 (42.98%), Postives = 144/235 (61.28%), Query Frame = 2

Query:  101 KSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKV-----NQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            +S  + +H  +   ++K   FTK+++P +P VF +W  Q+F  P++WY +   Y R+VAVMSMVGYILGLGDRH ENILF   +GD VH+D+N LFN G+ L +PEVVPFRLT NM   +GP G   G FR  C  TL LL+ E + +M++ +P  YD   +         ++  A       ++ + +RL+G V     N +PLS EG+VN+LI +A     L  MY+GWG+F+
Sbjct: 2295 QSLAVPLHESI---ERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLG-VEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQ--------TRKGAATAKITKDVQRIADRLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAFL 2517

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BLAST of Serine/threonine-protein kinase atr vs. UniProt/SwissProt
Match: sp|Q02099|RAD3_SCHPO (Protein kinase rad3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rad3 PE=1 SV=2)

HSP 1 Score: 194.897 bits (494), Expect = 2.793e-55
Identity = 93/215 (43.26%), Postives = 139/215 (64.65%), Query Frame = 2

Query:  161 FTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVN------QLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            F K++LP +P VF +WF++ FPEPN W  S Q YCR++AVMS+VGY+LGLGDRH ENILFD  +G+ +H+D+N LF+ G T E PE VPFRLT NM D +GP G   G FR +   T+ LLR+  + +M+V +   +       DPL++ N++ ++     N+  E+ + ++ K         +PLS+EG++  LI  A++ K L +MY+GW ++
Sbjct: 2179 FEKKILPKFPPVFYEWFVESFPEPNNWVTSRQNYCRTLAVMSIVGYVLGLGDRHGENILFDEFTGEAIHVDFNCLFDKGLTFEKPEKVPFRLTHNMVDAMGPTGYEGG-FRKASEITMRLLRSNQDTLMSVLESFLH-------DPLVEWNRKKSSSKYPNNEANEVLDIIRKKFQGFMPGETIPLSIEGQIQELIKSAVNPKNLVEMYIGWAAY 2385

HSP 2 Score: 42.743 bits (99), Expect = 2.793e-55
Identity = 20/53 (37.74%), Postives = 32/53 (60.38%), Query Frame = 1

Query:   13 GLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHA------RYAQRGDSFKKKV 153
            G IEWVN+T  FR++++  + Q+N PI +Q++        R    GD F+KK+
Sbjct: 2131 GFIEWVNHTRPFREILLKSYRQKNIPISYQEIKVDLDFALRSPNPGDIFEKKI 2183

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BLAST of Serine/threonine-protein kinase atr vs. TrEMBL
Match: K9KAF3 (Serine/threonine-protein kinase ATR-like protein (Fragment) OS=Equus caballus OX=9796 PE=2 SV=1)

HSP 1 Score: 235.343 bits (599), Expect = 2.681e-70
Identity = 118/243 (48.56%), Postives = 158/243 (65.02%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK----QSNAVTMTENKLE--EMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            GK     M      L +KL  F + +LP +P VF++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V K   +D L E   P+   +K    ++  V   + K    ++E RL+G      +V  LPLS+EG V+YLI +A DE LLCQMY+GW  ++
Sbjct:  290 GKELRQCMLPKAAALSEKLKVFREFLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 531

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BLAST of Serine/threonine-protein kinase atr vs. TrEMBL
Match: S7MYI1 (Serine/threonine-protein kinase ATR OS=Myotis brandtii OX=109478 GN=D623_10011361 PE=3 SV=1)

HSP 1 Score: 234.958 bits (598), Expect = 1.460e-69
Identity = 118/243 (48.56%), Postives = 158/243 (65.02%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK----QSNAVTMTENKLE--EMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            GK     M      L +KL  F + +LP +P VF++WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V K   +D L E   P+   +K    ++  V   + K    ++E RL+G      +V  LPLS+EG V+YLI +A DE LLCQMY+GW  ++
Sbjct:  349 GKELRQCMLPKAAALSEKLKVFQEFLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKALLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 590

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BLAST of Serine/threonine-protein kinase atr vs. TrEMBL
Match: F7FJ30 (Uncharacterized protein OS=Ornithorhynchus anatinus OX=9258 PE=3 SV=1)

HSP 1 Score: 240.35 bits (612), Expect = 6.023e-69
Identity = 122/243 (50.21%), Postives = 159/243 (65.43%), Query Frame = 2

Query:   98 GKSFTLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK-QSNAVTMTENK-----LEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            GK     M      L +KL  F + +LP +P VF +WFL+ FP+P +WY S   YCRS AVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PEVVPFRLTRNM +G+GP G   GLFR +C  T+ L+R++ EP+M+V K   +D L E   P+  S+K Q N      N+     + ++E RL+G      +V  LPLS+EG V+YLI +A DE LLCQMY+GW  ++
Sbjct:  779 GKELRQCMLPKTSTLAEKLKMFREHLLPRHPPVFYEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEVVPFRLTRNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGSSKAQVNETGEVINEKAKTHVLDIEQRLQGVIKTRNRVKGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYL 1020

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BLAST of Serine/threonine-protein kinase atr vs. TrEMBL
Match: A0A4W3HYM3 (Uncharacterized protein OS=Callorhinchus milii OX=7868 GN=atr PE=3 SV=1)

HSP 1 Score: 241.891 bits (616), Expect = 7.000e-69
Identity = 117/229 (51.09%), Postives = 156/229 (68.12%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK-QSNAVTMTENK-----LEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            L +KL  F +++LP +P VF++WFL+ FP+P +WY S   YCRSVAVMSMVGY+LGLGDRH ENILFD  +G+ VH+D+N LFN G+T + PE+VPFRLT NM   +GP G   GLFR +C  T  L+R++ EP+M+V K   +D L E   P+  S K Q N      N+     ++++E RL+G      KV  LPLS+EG V+YLI +A DEKLLCQMY+GW  ++
Sbjct: 2377 LSEKLSLFKQQLLPRHPAVFHEWFLRTFPDPTSWYSSRSAYCRSVAVMSMVGYVLGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFDVPEIVPFRLTHNMSHAMGPMG-TEGLFRRACEVTTRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGSTKSQVNETGEVINEKAKTHVQDIEKRLQGVIKTRNKVKGLPLSIEGHVHYLIHEATDEKLLCQMYLGWAPYM 2604

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BLAST of Serine/threonine-protein kinase atr vs. TrEMBL
Match: A0A2I0TAT3 (Uncharacterized protein OS=Limosa lapponica baueri OX=1758121 GN=llap_18788 PE=3 SV=1)

HSP 1 Score: 233.417 bits (594), Expect = 1.034e-68
Identity = 114/230 (49.57%), Postives = 155/230 (67.39%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTE-------NKLEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            L +KL  F + +LP +P +F++WFL+ FP+P +WY S   YCRSVAVMSMVGYILGLGDRH ENILFD  +G+ VH+D+N LFN G+T E PE+VPFRLT NM +G+GP G   GLFR +C  T+ L+R++ EP+M+V K   +D L E   P +K N ++      E         + ++E RL+G      ++  LPLS+EG V+YLI +A D+ LLCQMYMGW  ++
Sbjct:  405 LSEKLKMFKEVLLPRHPPLFHEWFLRTFPDPTSWYNSRSAYCRSVAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG-TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKP-VKGNTKAQVNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRIKGLPLSIEGHVHYLIQEASDDNLLCQMYMGWAPYM 632

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Cavefish
Match: atr (ATR serine/threonine kinase [Source:ZFIN;Acc:ZDB-GENE-070912-458])

HSP 1 Score: 230.72 bits (587), Expect = 1.646e-68
Identity = 118/230 (51.30%), Postives = 157/230 (68.26%), Query Frame = 2

Query:  140 LKKKLMKFTKEVL-PLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNK-QSNAVTMTENK-----LEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            L++KL K  K+VL   +P VF+ WFL+ FP+P +WY S   YCRS AVMSMVGY+LGLGDRH ENILFD  +G+ VH+D+N LFN G+T + PEVVPFRLT+NM   +GP G   GLFR +C  TL L+R++ EP+M+V K   +D L E   P+  S K Q+N      N+     ++++E RL+G      KV  LPLS+EG V+YLI +A D+ LLCQMY+GWG ++
Sbjct: 2208 LQEKL-KLHKDVLCARHPPVFHDWFLRTFPDPTSWYNSRSAYCRSTAVMSMVGYVLGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFDVPEVVPFRLTQNMVHAMGPMG-TEGLFRQACEVTLRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGSLKTQANESGEIVNEKAKTHVQDIEQRLQGVIKNRNKVMGLPLSIEGHVHYLIQEATDDNLLCQMYLGWGPYL 2435

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Cavefish
Match: atm (ATM serine/threonine kinase [Source:ZFIN;Acc:ZDB-GENE-040809-1])

HSP 1 Score: 144.436 bits (363), Expect = 1.506e-38
Identity = 87/247 (35.22%), Postives = 129/247 (52.23%), Query Frame = 2

Query:  146 KKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE-VKDPLI-------------------------------KSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            KKL  FT EV   +  VF  + +++F +P  W      Y RSVA  S+VGYI+GLGDRHI+NIL D  + ++VHID    F  GK L  PE VPFRL+R++ DG+G  G   G+FR  C  T+ ++R+  E ++ + + + YD L +   +PL                                KS+   +   + E  L  ++ +LKG      LSV G+VN LI QA+D K L +++ GW +++
Sbjct: 2812 KKLQAFT-EVCQNFRPVFRYFCMERFLDPAVWLEKRLAYTRSVATSSIVGYIVGLGDRHIQNILIDEQTAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGV-EGVFRRCCEKTMEVMRSSQEVLLTIVEVLLYDPLFDWTMNPLKAFHLQQQQDEQAELNATLNPTPAGEEPEAHRKSSDSQSFNKVAERVLLRLQEKLKGVEEGAVLSVGGQVNLLIQQAMDPKNLSRLFPGWQAWV 3056

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Cavefish
Match: atm (ATM serine/threonine kinase [Source:ZFIN;Acc:ZDB-GENE-040809-1])

HSP 1 Score: 143.665 bits (361), Expect = 2.972e-38
Identity = 87/247 (35.22%), Postives = 129/247 (52.23%), Query Frame = 2

Query:  146 KKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE-VKDPLI-------------------------------KSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            KKL  FT EV   +  VF  + +++F +P  W      Y RSVA  S+VGYI+GLGDRHI+NIL D  + ++VHID    F  GK L  PE VPFRL+R++ DG+G  G   G+FR  C  T+ ++R+  E ++ + + + YD L +   +PL                                KS+   +   + E  L  ++ +LKG      LSV G+VN LI QA+D K L +++ GW +++
Sbjct: 2786 KKLQAFT-EVCQNFRPVFRYFCMERFLDPAVWLEKRLAYTRSVATSSIVGYIVGLGDRHIQNILIDEQTAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITG-VEGVFRRCCEKTMEVMRSSQEVLLTIVEVLLYDPLFDWTMNPLKAFHLQQQQDEQAELNATLNPTPAGEEPEAHRKSSDSQSFNKVAERVLLRLQEKLKGVEEGAVLSVGGQVNLLIQQAMDPKNLSRLFPGWQAWV 3030

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Cavefish
Match: smg1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase [Source:ZFIN;Acc:ZDB-GENE-061013-767])

HSP 1 Score: 131.724 bits (330), Expect = 3.892e-34
Identity = 59/119 (49.58%), Postives = 80/119 (67.23%), Query Frame = 2

Query:  230 PNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
            P+ W+R  Q Y RS AVMSMVGYI+GLGDRH++N+L D T+G+VVHIDYN  F  GK+L  PE VPFR+T N++  LG  G   G+FR SC   + ++R   E ++ + +   YD L +
Sbjct: 2291 PSEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTHNIETALGVTGV-EGIFRLSCEQVVQMMRRGRETLLTLLEAFVYDPLVD 2408

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Cavefish
Match: mtor (mechanistic target of rapamycin kinase [Source:NCBI gene;Acc:103042377])

HSP 1 Score: 110.538 bits (275), Expect = 7.916e-27
Identity = 77/244 (31.56%), Postives = 107/244 (43.85%), Query Frame = 2

Query:  218 KFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLE-WPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLT--EVKDPLIKSNKQSNAVT---MTENKLEEME------------------------------------------NRLKGKV------NQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            K P    W+     Y RS+AVMSMVGYILGLGDRH  N++ D  SG ++HID+   F    T E +PE +PFRLTR + + +   G  +G +R +C   + +LR   + +MAV +   YD L    + D   K  K+S   T        +E ME                                          NR++ K+      +   L V  +V  LI QA   + LCQ Y+GW  F
Sbjct: 2275 KSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTG-LDGNYRITCHTVMEVLREHRDSVMAVLEAFVYDPLLNWRLMDTNTKGTKRSRTRTDSYTAGQSVETMEGIDLGETTHKKPGTTVPESIHSFIGDGLVQPEALNKKAIQIINRVRDKLTGRDFSHDETLDVPTQVELLIKQATSHENLCQCYIGWCPF 2517

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003429.1 (pep scaffold:Pmarinus_7.0:GL476508:503342:564700:-1 gene:ENSPMAG00000003096.1 transcript:ENSPMAT00000003429.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 206.453 bits (524), Expect = 8.586e-61
Identity = 107/232 (46.12%), Postives = 148/232 (63.79%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIM---AVFKPMYYDTLTEVKDPLIKS-----NKQSNAVTMTENKL-EEMENRLKG-------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            L++KL  +  ++LP +P VF++WFL+ FP+P +WY S   Y RS AVMSMVGY+LGLGDRH ENILFD  +G+ +H+D+N LFN G T   PE+VPFRLT NM   +GP G   GLFR +C  T+ ++ ++ E ++   +V K   +D L E   PL  S     N+    V     ++ +++E RL G       +V  LPLS+EG V+YLI +A +EKLLCQMY+GW  F
Sbjct: 2409 LEQKLSMYRDKLLPPHPPVFHEWFLRTFPDPTSWYSSRLGYTRSTAVMSMVGYVLGLGDRHGENILFDSLTGECMHVDFNCLFNKGLTFGVPELVPFRLTHNMVHAMGPMGL-EGLFRRACEVTMRVMCDQRESLIRGASVLKTFIHDPLVEWSRPLHGSWRGSANEAGEVVNEKAKQIVQDIEQRLHGVIKNPNNRVRGLPLSIEGHVHYLIQEATNEKLLCQMYLGWAPF 2639

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003412.1 (pep scaffold:Pmarinus_7.0:GL476508:503342:564700:-1 gene:ENSPMAG00000003096.1 transcript:ENSPMAT00000003412.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 206.453 bits (524), Expect = 8.678e-61
Identity = 107/232 (46.12%), Postives = 148/232 (63.79%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIM---AVFKPMYYDTLTEVKDPLIKS-----NKQSNAVTMTENKL-EEMENRLKG-------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            L++KL  +  ++LP +P VF++WFL+ FP+P +WY S   Y RS AVMSMVGY+LGLGDRH ENILFD  +G+ +H+D+N LFN G T   PE+VPFRLT NM   +GP G   GLFR +C  T+ ++ ++ E ++   +V K   +D L E   PL  S     N+    V     ++ +++E RL G       +V  LPLS+EG V+YLI +A +EKLLCQMY+GW  F
Sbjct: 2443 LEQKLSMYRDKLLPPHPPVFHEWFLRTFPDPTSWYSSRLGYTRSTAVMSMVGYVLGLGDRHGENILFDSLTGECMHVDFNCLFNKGLTFGVPELVPFRLTHNMVHAMGPMG-LEGLFRRACEVTMRVMCDQRESLIRGASVLKTFIHDPLVEWSRPLHGSWRGSANEAGEVVNEKAKQIVQDIEQRLHGVIKNPNNRVRGLPLSIEGHVHYLIQEATNEKLLCQMYLGWAPF 2673

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003421.1 (pep scaffold:Pmarinus_7.0:GL476508:503342:564700:-1 gene:ENSPMAG00000003096.1 transcript:ENSPMAT00000003421.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 206.453 bits (524), Expect = 9.738e-61
Identity = 107/232 (46.12%), Postives = 148/232 (63.79%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIM---AVFKPMYYDTLTEVKDPLIKS-----NKQSNAVTMTENKL-EEMENRLKG-------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            L++KL  +  ++LP +P VF++WFL+ FP+P +WY S   Y RS AVMSMVGY+LGLGDRH ENILFD  +G+ +H+D+N LFN G T   PE+VPFRLT NM   +GP G   GLFR +C  T+ ++ ++ E ++   +V K   +D L E   PL  S     N+    V     ++ +++E RL G       +V  LPLS+EG V+YLI +A +EKLLCQMY+GW  F
Sbjct: 2429 LEQKLSMYRDKLLPPHPPVFHEWFLRTFPDPTSWYSSRLGYTRSTAVMSMVGYVLGLGDRHGENILFDSLTGECMHVDFNCLFNKGLTFGVPELVPFRLTHNMVHAMGPMG-LEGLFRRACEVTMRVMCDQRESLIRGASVLKTFIHDPLVEWSRPLHGSWRGSANEAGEVVNEKAKQIVQDIEQRLHGVIKNPNNRVRGLPLSIEGHVHYLIQEATNEKLLCQMYLGWAPF 2659

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007186.1 (pep scaffold:Pmarinus_7.0:GL476459:175296:202639:-1 gene:ENSPMAG00000006485.1 transcript:ENSPMAT00000007186.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 143.665 bits (361), Expect = 5.125e-39
Identity = 83/236 (35.17%), Postives = 121/236 (51.27%), Query Frame = 2

Query:  194 VFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE-VKDPLIKSNKQSNAVTMTE-------------------------------NKLEE-----MENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            VF  +F ++F +P  W+     Y RSVA  S+VGYI+GLGDRH++NIL D  S ++VHID    F  G+ L  PE VPFRLTR++ DG+G  G   G+FR  C  T+ ++RN  E ++ + + + +D L +   +PL     Q+     TE                               NK+ E     ++ +LKG      LSV G+VN LI QA D K L +++ GW  ++
Sbjct:  868 VFRHFFWERFLDPAVWFERRLSYTRSVATSSIVGYIVGLGDRHVQNILIDLNSAELVHIDLGVAFEQGRILPTPETVPFRLTRDIVDGMGITGV-EGVFRRCCEKTMEVMRNSQEALLTIVEVLLFDPLFDWTMNPLKALTLQTRTEDETEGTSTMGPTLGKAPASGRAVHQERNGMDPQSLNKMAERVLMRLQQKLKGVEEGSVLSVPGQVNLLIQQATDPKNLSRLFPGWQPWV 1102

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002453.1 (pep scaffold:Pmarinus_7.0:GL482029:21191:33947:1 gene:ENSPMAG00000002221.1 transcript:ENSPMAT00000002453.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 54.6842 bits (130), Expect = 1.039e-8
Identity = 43/143 (30.07%), Postives = 67/143 (46.85%), Query Frame = 2

Query:  245 RSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWP---EVVPFRLTRNMQDGLGPCGENNGLFR---SSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLE 655
            ++V+K+  S A   M  Y+LG+GDRH ENI+    +G++ HID+  +  + K   W    E VPF LT +    LG     N  F+    +C      LR     ++ +F  M    + EV    I+  +++  V  TE   E
Sbjct:  903 QAVEKFMHSCAGYCMATYVLGIGDRHNENIMIT-KNGNLFHIDFGHILGNIKKF-WGVSRERVPFVLTPDFLCILGAHKNKNLYFQRFVDTCCRAYLALRRHKNLLITLFNMMATTGMPEVTPRDIEHMREALVVRATEADAE 1043

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Yeast
Match: MEC1 (Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres [Source:SGD;Acc:S000000340])

HSP 1 Score: 154.066 bits (388), Expect = 8.234e-43
Identity = 85/213 (39.91%), Postives = 119/213 (55.87%), Query Frame = 2

Query:  155 MKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQ--LPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            ++F  E +  +P +  +WFL+ FP+P  W+ +   Y RS AVM+MVG+ILGLGDRH ENIL D  +G V+H+D++ LF  GK L  PE+VPFRLT N+ D LG  G   G F+ S   TL L+R     +M V + + YD                N     +  L+ + N+++G   Q  L LSV G+   LI +A  E  L +MY+GW  F
Sbjct: 2171 LEFYMEQVDKFPPILYQWFLENFPDPINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLPVPEIVPFRLTPNLLDALGIIG-TEGTFKKSSEVTLALMRKNEVALMNVIETIMYD---------------RNMDHSIQKALKVLRNKIRGIDPQDGLVLSVAGQTETLIQEATSEDNLSKMYIGWLPF 2367

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Yeast
Match: TEL1 (Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; acts with Red1p and Mec1p to promote interhomolog recombination by phosphorylation of Hop1; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene [Source:SGD;Acc:S000000184])

HSP 1 Score: 141.354 bits (355), Expect = 2.065e-38
Identity = 88/232 (37.93%), Postives = 123/232 (53.02%), Query Frame = 2

Query:  146 KKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAV-----FKPMY---------YDTLTEVKDPLIKSNKQSNAVTMTE-NKLEEMENRLKGKVNQL---PLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            K  +K T E+ P        +F   FP+P  W+ + + Y + VA  S+VGYILGLGDRH+ NIL D ++G+ +HID    F+ GK L  PE+VPFRLTR++ DG G  G  +GLFR SC     +LR +   +M V     + P+Y         Y+ L E +  +   +  S  ++  + N+ +E    LKG   +L    LSVE  V  LI QA D   L  +YMGW  F
Sbjct: 2560 KAYLKITNEIKP----QLRNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPELVPFRLTRDIVDGFGVTGV-DGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPLYSWVMSPVKKYEHLFEEEHEITNFDNVSKFISNNDRNENQESYRALKGVEEKLMGNGLSVESSVQDLIQQATDPSNLSVIYMGWSPF 2786

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Yeast
Match: TOR2 (PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication [Source:SGD;Acc:S000001686])

HSP 1 Score: 110.538 bits (275), Expect = 1.014e-27
Identity = 75/240 (31.25%), Postives = 111/240 (46.25%), Query Frame = 2

Query:  182 LYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLE-WPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTL---------------TEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQL----------------------PLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            LY V+   W   +  E   W      Y RS+AVMSM GYILGLGDRH  N++ D  +G V+HID+   F      E +PE VPFRLTR +   +   G   G FR +C   + +LR+    +MA+ +   +D L               T ++ P++ +N+  +   +TE +++ +EN  K  +                          L V  +V+ LI QA   + LCQ Y+GW  F
Sbjct: 2240 LYKVL---WLKSRSSE--TWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVSG-IEGSFRITCENVMKVLRDNKGSLMAILEAFAFDPLINWGFDLPTKKIEEETGIQLPVMNANELLSNGAITEEEVQRVENEHKNAIRNARAMLVLKRITDKLTGNDIRRFNDLDVPEQVDKLIQQATSVENLCQHYIGWCPF 2473

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Yeast
Match: TOR1 (PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication [Source:SGD;Acc:S000003827])

HSP 1 Score: 107.457 bits (267), Expect = 1.031e-26
Identity = 75/222 (33.78%), Postives = 102/222 (45.95%), Query Frame = 2

Query:  236 AWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLE-WPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTL---------------TEVKDPLIKSNK--QSNAVTMTE--NKLEEMENRLKGKVNQL------------------PLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
             W      Y RS+AVMSM GYILGLGDRH  N++ D  +G V+HID+   F      E +PE VPFRLTR +   +   G   G FR +C   + +LR+  E +MA+ +    D L               T +  PLI  ++  +  A+T+ E  N   E +N  K     L                   L V  +V+ LI QA   + LCQ Y+GW  F
Sbjct: 2249 TWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPEKVPFRLTRMLTYAMEVSG-IEGSFRITCENVMRVLRDNKESLMAILEAFALDPLIHWGFDLPPQKLTEQTGIPLPLINPSELLRKGAITVEEAANMEAEQQNETKNARAMLVLRRITDKLTGNDIKRFNELDVPEQVDKLIQQATSIERLCQHYIGWCPF 2469

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Yeast
Match: PIK1 (Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; may control nonselective autophagy and mitophagy through trafficking of Atg9p [Source:SGD;Acc:S000005211])

HSP 1 Score: 56.6102 bits (135), Expect = 1.234e-9
Identity = 52/198 (26.26%), Postives = 96/198 (48.48%), Query Frame = 2

Query:  110 TLVMHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAW-YRSVQK-YCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPC-GENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSN---KQSNAVTMTENKLEE-MENRLKGK 682
             + +H++   L KK+++  +          N  FL+ F  PN + YR  Q  +  S+A  S++ Y+L + DRH  NI+ D+  G V HID+  + ++       E  PF+LT    + LG   GE    F     ++   LR   + I+++ + M  D +    D   +++   +Q   + ++E ++++ +EN L GK
Sbjct:  848 AMSVHSIKKALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDN-EGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDDFVENFLIGK 1044

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Nematostella
Match: EDO29217 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T497])

HSP 1 Score: 187.578 bits (475), Expect = 2.529e-59
Identity = 98/214 (45.79%), Postives = 135/214 (63.08%), Query Frame = 2

Query:  182 LYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPL-----IKSNKQSNAVTMTE--NKLEEMENRLKGKVNQ----LPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            ++P VF +WFL+ F  P +WY S   YCR+ AVMSMVGYILGLGDRH ENILFD T+G+ VH+D N LFN G+T + PE VPFRLT N+ D +G  G   G++R SC  TL L+R++ + ++ V     +D L E   P         +K +  VT  E    L+ +E RLKG  ++    +PLS+EG+V+ LI +A D + L QMY+GW  ++
Sbjct:    1 MHPPVFGEWFLKAFQNPTSWYESRLAYCRTTAVMSMVGYILGLGDRHGENILFDSTNGECVHVDLNCLFNKGETFDCPERVPFRLTHNLVDAMGLLG-YEGVYRRSCEVTLRLMRSQCDSLLTVLGTFIHDPLMEWLRPRGTPGDPSKSKDTGEVTNEEAVKILKSIEQRLKGYYSKNKIMIPLSIEGQVHKLITEATDIQNLAQMYIGWAPYL 213

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Nematostella
Match: EDO36404 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIS1])

HSP 1 Score: 154.836 bits (390), Expect = 1.497e-42
Identity = 85/232 (36.64%), Postives = 124/232 (53.45%), Query Frame = 2

Query:  194 VFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYD-----TLTEVKDPLIKSNKQSNAVT----------------------------MTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            VF  +FL+KF +P  W+     Y RS A  S+VGYI+GLGDRH++NIL D  S ++VHID    F  GK L  PE VPFRLTR++ DG+G  G   G+FR  C  T+ ++R   E ++ + + + YD     TL+  K   +++ K  N V+                            M E  L  ++ +L G  +   LSV G+VN+LI QA+D K LC+++ GW  ++
Sbjct: 1492 VFRHFFLEKFVDPAEWFERRLAYTRSCATSSIVGYIVGLGDRHVQNILVDCNSAELVHIDLGVAFEQGKVLPTPETVPFRLTRDLVDGMGVTGV-EGVFRRCCEKTMAVMRTSQEALVTILEVLLYDPLYSWTLSPEKKMALQATKPDNDVSEISSTAVDLVGDLPNGENTENGASVGNKMAERVLSRLKQKLNGIEDNTQLSVTGQVNHLIRQAMDVKNLCRLFPGWQPWV 1722

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Nematostella
Match: EDO48437 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJW4])

HSP 1 Score: 119.783 bits (299), Expect = 1.641e-30
Identity = 55/116 (47.41%), Postives = 76/116 (65.52%), Query Frame = 2

Query:  239 WYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
            W+   + Y RS AVMSM+GYI+GLGDRH++N+L D T+G+VVHIDYN  F  G+ L  PE VPFR+T N++  LG  G   G+FR SC   L +L+   E ++ + +   YD L +
Sbjct:  607 WWHMTKTYARSTAVMSMIGYIIGLGDRHLDNMLIDFTTGEVVHIDYNVCFEKGRGLRVPEKVPFRMTPNLEMALGVTGV-EGMFRLSCEQVLKILKQGRETLLTLLEAFVYDPLVD 721

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Nematostella
Match: EDO44977 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU99])

HSP 1 Score: 113.235 bits (282), Expect = 3.115e-28
Identity = 76/242 (31.40%), Postives = 111/242 (45.87%), Query Frame = 2

Query:  218 KFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLE-WPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYD-----TLTEVKDPLIKSNKQSNAVTMTENKLEEME--------------------------------------------NRLKGK--VNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            K P    W+     Y RS+AVMSMVGY+LGLGDRH  N++ D  +G ++HID+   F    T E +PE +PFRLTR + + +   G  +G +R +C + +  +R   + +MAV +   YD      L +   P IK +K   + TMTE   E +E                                            ++L G+   N+  L V  +V+ LI QA   + LCQ Y+GW  F
Sbjct: 2235 KSPSSEVWFDRRTNYTRSLAVMSMVGYVLGLGDRHPSNLMLDRLTGRILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTG-IDGNYRLTCESVMRTMREHKDSVMAVLEAFVYDPLLNWRLMDNAAPKIKRSK-GRSDTMTEAAEEMLEGVDVNRDKPSAKKPAEPLHSIEEETGHKPEFLNKKALDIITRVRDKLTGRDFANRNTLDVPTQVDLLIKQATAHENLCQCYIGWCPF 2474

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Nematostella
Match: EDO34280 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPT8])

HSP 1 Score: 77.411 bits (189), Expect = 5.869e-16
Identity = 63/247 (25.51%), Postives = 113/247 (45.75%), Query Frame = 2

Query:  194 VFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHG-KTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPI---MAVF--KP--------------------MYYDTLTEV-KDPLIKSNKQ---SNAVTMTENKLE------------------EMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            +  + F Q    P A+      + R+ A + +  Y+LG+GDRH+ N L D  +G ++ ID+   F    + L  PE+VPFRLTR   + L P  E +GL R++ +  +  LR   E +   M VF  +P                    MYY+ LT   ++ ++ + ++   +N   +T  +LE                  +  + ++ +  +  L+ E +V+ LI QA D  +L + + GW +++
Sbjct: 1615 LLRRAFQQLAASPEAYLTLRTHFARTHACICICQYVLGIGDRHLSNFLVDMRTGGLIGIDFGHSFGSATQFLPVPELVPFRLTRQFTNLLLPLKE-SGLVRNTMIHVMRALRGNHELLLNTMDVFVKEPSLDWQMFARKQAEDQHMEIGMYYEDLTWYPREKVLTAQRKLKGANPAFVTRQELELGHRRRSWFRNLQSACLGDRRHNVRAQKEENELTSEAQVDCLIDQATDVNILGRAWEGWEAWV 1860

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Medaka
Match: atr (ATR serine/threonine kinase [Source:NCBI gene;Acc:101157099])

HSP 1 Score: 215.312 bits (547), Expect = 3.498e-63
Identity = 120/255 (47.06%), Postives = 163/255 (63.92%), Query Frame = 2

Query:   74 YKETIL*FGKSFTLVMHNVVILLKKKLMKFTKEVL-PLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTE---------NKLEEMENRLKG------KVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            YKE +   GK    ++       ++KL +  KEVL   +P VF++WFL+ FP+P +   S   YCRS AVMSMVGY+LGLGDRH ENILFD  +G+ VH+D+N LFN G+T + PEVVPFRLT+NM   +GP G   GLFR +C  TL L+R++ EP+M V K       T + DPL++ +KQ+  ++ T+           + ++E RL G      KV  LPLS+EG V+YLI +A DEKLLCQMY+GWG ++
Sbjct: 1919 YKERVYLSGKELRKLILPKTAPFEEKL-RIHKEVLCARHPPVFHEWFLRTFPDPTS---SRSAYCRSTAVMSMVGYVLGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFDVPEVVPFRLTQNMVHAMGPMG-TEGLFRQACEVTLRLMRDQREPLM-VLK-------TFLHDPLVEWSKQTKGLSKTQVHETGEIAKTHVCDIEQRLLGVIKSRNKVLGLPLSIEGHVHYLIQEATDEKLLCQMYLGWGPYL 2160

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Medaka
Match: mtor (mechanistic target of rapamycin kinase [Source:ZFIN;Acc:ZDB-GENE-030131-2974])

HSP 1 Score: 109.768 bits (273), Expect = 1.009e-26
Identity = 75/244 (30.74%), Postives = 107/244 (43.85%), Query Frame = 2

Query:  218 KFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLE-WPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLT--EVKDPLIKSNKQSNAVTMTENKLEEME---------------------------------------------NRLKGKV------NQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSF 787
            K P    W+     Y RS+AVMSMVGYILGLGDRH  N++ D  SG ++HID+   F    T E +PE +PFRLTR + + +   G  +G +R +C   + +LR   + +MAV +   YD L    + D   K  K+S   T +    + +E                                             NR++ K+      +   L V  +V  LI QA   + LCQ Y+GW  F
Sbjct:  494 KSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGL-DGNYRITCHTVMEVLREHRDSVMAVLEAFVYDPLLNWRLMDSNTKGTKRSRTRTDSYTAGQSVEALEGIDLGETTHKKAGTTVPESIHSFIGDGLVQPEALNKKAIQIINRVRDKLTGRDFSHDETLDVPTQVELLIKQATSHENLCQCYIGWCPF 736

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BLAST of Serine/threonine-protein kinase atr vs. Ensembl Medaka
Match: prkdc (protein kinase, DNA-activated, catalytic subunit [Source:NCBI gene;Acc:101171206])

HSP 1 Score: 65.855 bits (159), Expect = 6.609e-12
Identity = 67/256 (26.17%), Postives = 109/256 (42.58%), Query Frame = 2

Query:  170 EVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHG-KTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPI---MAVF--KPMYYDTLTEVKD-------------------PLIKSN------------------------KQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
            +VL   P    + FL+    P A+      +  S A++ +  +ILG+GDRH+ N + +  +G ++ ID+   F    + L  PE++PFRLT+   + + P  E +GL +S  V +L   R E + +   M VF  +P       EVK                    PL K N                        K ++   M    L   E+ ++ K+    LSVE +V  L+  A D  +L ++Y+GW  +I
Sbjct: 3708 KVLQHVPADLLRSFLRMCNSPEAFLSLRSHFISSHALLCVSHWILGIGDRHLSNFMVNVETGGMIGIDFGHAFGSATQFLPVPELMPFRLTQQFVNLMQPLKE-SGLIQSIMVHSLRAYRAEPDLLLNTMDVFIKEPCLDWKNFEVKQLRKGGTWTDSVNTKEVNWYPLQKVNFARRKLEGANPAAITSEELKLGFEKDASFAGMQAVALGSEEHNVRAKLPASGLSVEKQVECLLDHATDPNVLGRVYVGWEPWI 3962

HSP 2 Score: 23.0978 bits (48), Expect = 6.609e-12
Identity = 9/25 (36.00%), Postives = 13/25 (52.00%), Query Frame = 1

Query:   13 GLIEWVNNTESFRQVVVDLHIQRNN 87
            GLIEW+ NT + +  V     +  N
Sbjct: 3670 GLIEWMENTCTLKDFVYKTMTEEEN 3694

[Close]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Medaka
Match: si:rp71-17i16.5 (phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [Source:NCBI gene;Acc:101159013])

HSP 1 Score: 58.9214 bits (141), Expect = 2.118e-9
Identity = 38/135 (28.15%), Postives = 66/135 (48.89%), Query Frame = 2

Query:  203 KWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTL--EWPEVVPFRLTRNMQDGLGPCGENNGL----FRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEV 589
            +W   K P     Y++V+++ +S A   +  Y+LG+GDRH +NI+     G++ HID+  +  + K       E VPF LT +    +G    +N L    F  +C+    LLR   + ++ +F  M    + E+
Sbjct:  920 EWLKSKCPLQEIHYKTVERFVKSCAGYCVAMYVLGIGDRHNDNIMITD-QGNLFHIDFGHILGNRKQFLGMKRERVPFVLTPDFLYVMGRVKSHNSLYFQKFVDTCIQAYLLLRPHSQLLVTLFSLMLLTGIPEL 1053

[Close]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Medaka
Match: pik3cg (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [Source:NCBI gene;Acc:101173828])

HSP 1 Score: 55.4546 bits (132), Expect = 2.429e-8
Identity = 35/133 (26.32%), Postives = 65/133 (48.87%), Query Frame = 2

Query:  194 VFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTL-----EWPEVVPFRLTRNMQDGLGPCGENNG----LFRSSCVATLNLLRNEIEPIMAVFKPM 565
            + ++W   K    + + ++V+++  S     +  Y+LG+GDRH +NI+    SG++ HID+  +  + K+      EW   VPF LT +    +G  G+ +      F+  CV     LR+    ++ +F  M
Sbjct:  847 ILHQWLRDKCVSEDKFQQAVERFLLSCGGYCVATYVLGIGDRHNDNIMITE-SGNLFHIDFGHILGNYKSFMGISKEW---VPFVLTPDFLYVMGTSGKKSSPHFLKFQDVCVKAYLALRHHTNLLIILFSMM 975

[Close]

BLAST of Serine/threonine-protein kinase atr vs. Planmine SMEST
Match: SMESG000018015.1 (SMESG000018015.1)

HSP 1 Score: 454.521 bits (1168), Expect = 1.075e-152
Identity = 214/217 (98.62%), Postives = 215/217 (99.08%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
             +KKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYN LFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI
Sbjct: 1168 FEKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNCLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 1384

HSP 2 Score: 104.76 bits (260), Expect = 1.075e-152
Identity = 47/49 (95.92%), Postives = 49/49 (100.00%), Query Frame = 1

Query:    7 KSGLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHARYAQRGDSFKKKV 153
            KSGLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHARYAQRGDSF+KK+
Sbjct: 1124 KSGLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHARYAQRGDSFEKKL 1172

[Close]

BLAST of Serine/threonine-protein kinase atr vs. Planmine SMEST
Match: SMESG000018015.1 (SMESG000018015.1)

HSP 1 Score: 454.521 bits (1168), Expect = 1.149e-152
Identity = 214/217 (98.62%), Postives = 215/217 (99.08%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
             +KKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYN LFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI
Sbjct: 1170 FEKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNCLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 1386

HSP 2 Score: 104.76 bits (260), Expect = 1.149e-152
Identity = 47/49 (95.92%), Postives = 49/49 (100.00%), Query Frame = 1

Query:    7 KSGLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHARYAQRGDSFKKKV 153
            KSGLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHARYAQRGDSF+KK+
Sbjct: 1126 KSGLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHARYAQRGDSFEKKL 1174

[Close]

BLAST of Serine/threonine-protein kinase atr vs. Planmine SMEST
Match: SMESG000018015.1 (SMESG000018015.1)

HSP 1 Score: 454.521 bits (1168), Expect = 1.239e-152
Identity = 214/217 (98.62%), Postives = 215/217 (99.08%), Query Frame = 2

Query:  140 LKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 790
             +KKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYN LFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI
Sbjct: 1154 FEKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNCLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEVNYLIAQAIDEKLLCQMYMGWGSFI 1370

HSP 2 Score: 104.76 bits (260), Expect = 1.239e-152
Identity = 47/49 (95.92%), Postives = 49/49 (100.00%), Query Frame = 1

Query:    7 KSGLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHARYAQRGDSFKKKV 153
            KSGLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHARYAQRGDSF+KK+
Sbjct: 1110 KSGLIEWVNNTESFRQVVVDLHIQRNNPIIWQKLHARYAQRGDSFEKKL 1158

[Close]

BLAST of Serine/threonine-protein kinase atr vs. Planmine SMEST
Match: SMESG000009788.1 (SMESG000009788.1)

HSP 1 Score: 103.99 bits (258), Expect = 9.884e-25
Identity = 48/119 (40.34%), Postives = 74/119 (62.18%), Query Frame = 2

Query:  230 PNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
             N WYRS   + RS AVM ++G+ LGLGDRH++N+L + ++G ++HIDYN  F+ G +L+ PE VPFRLT  + +  GP    NGLFR SC     +++   + I+ +     +D + +
Sbjct: 2201 SNNWYRSSINFTRSCAVMCIMGHCLGLGDRHLDNLLVNFSNGQMIHIDYNVCFDKGVSLKVPEKVPFRLTDIITNVFGPMAV-NGLFRISCENVYEIIQQSQDSILTLMDMFIFDPIVD 2318

[Close]

BLAST of Serine/threonine-protein kinase atr vs. Planmine SMEST
Match: SMESG000009788.1 (SMESG000009788.1)

HSP 1 Score: 103.99 bits (258), Expect = 1.027e-24
Identity = 48/119 (40.34%), Postives = 74/119 (62.18%), Query Frame = 2

Query:  230 PNAWYRSVQKYCRSVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPEVVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMYYDTLTE 586
             N WYRS   + RS AVM ++G+ LGLGDRH++N+L + ++G ++HIDYN  F+ G +L+ PE VPFRLT  + +  GP    NGLFR SC     +++   + I+ +     +D + +
Sbjct: 2236 SNNWYRSSINFTRSCAVMCIMGHCLGLGDRHLDNLLVNFSNGQMIHIDYNVCFDKGVSLKVPEKVPFRLTDIITNVFGPMAV-NGLFRISCENVYEIIQQSQDSILTLMDMFIFDPIVD 2353

The following BLAST results are available for this feature:

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Human
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Celegans
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Fly
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Zebrafish
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Xenopus
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Mouse
BLAST of Serine/threonine-protein kinase atr vs. UniProt/SwissProt
BLAST of Serine/threonine-protein kinase atr vs. TrEMBL
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Cavefish
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Sea Lamprey
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Yeast
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Nematostella
BLAST of Serine/threonine-protein kinase atr vs. Ensembl Medaka
BLAST of Serine/threonine-protein kinase atr vs. Planmine SMEST

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ATR	8.325e-70	48.15	ATR serine/threonine kinase [Source:HGNC Symbol;Ac...	[more]
ATR	8.586e-70	48.15	ATR serine/threonine kinase [Source:HGNC Symbol;Ac...	[more]
ATR	2.852e-54	52.38	ATR serine/threonine kinase [Source:HGNC Symbol;Ac...	[more]
ATM	5.855e-39	37.12	ATM serine/threonine kinase [Source:HGNC Symbol;Ac...	[more]
ATM	5.855e-39	37.12	ATM serine/threonine kinase [Source:HGNC Symbol;Ac...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
atl-1	3.581e-35	36.12	Serine/threonine-protein kinase ATR [Source:UniPr...	[more]
atl-1	3.955e-35	36.97	Serine/threonine-protein kinase ATR [Source:UniPr...	[more]
atl-1	3.955e-35	36.97	Serine/threonine-protein kinase ATR [Source:UniPr...	[more]
atl-1	4.112e-35	36.97	Serine/threonine-protein kinase ATR [Source:UniPr...	[more]
smg-1	2.016e-31	49.17	Serine/threonine-protein kinase smg-1 [Source:Uni...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mei-41	4.587e-59	42.98	gene:FBgn0004367 transcript:FBtr0074271	[more]
tefu	1.651e-35	37.38	gene:FBgn0045035 transcript:FBtr0110874	[more]
nonC	8.789e-30	45.69	gene:FBgn0263968 transcript:FBtr0070972	[more]
nonC	8.789e-30	45.69	gene:FBgn0263968 transcript:FBtr0343321	[more]
Tor	2.420e-27	31.56	gene:FBgn0021796 transcript:FBtr0336615	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
atr	1.788e-65	49.78	ATR serine/threonine kinase [Source:ZFIN;Acc:ZDB-G...	[more]
atm	4.818e-38	35.10	ATM serine/threonine kinase [Source:ZFIN;Acc:ZDB-G...	[more]
atm	5.869e-38	35.10	ATM serine/threonine kinase [Source:ZFIN;Acc:ZDB-G...	[more]
smg1	5.059e-33	48.74	SMG1 nonsense mediated mRNA decay associated PI3K ...	[more]
smg1	5.059e-33	48.74	SMG1 nonsense mediated mRNA decay associated PI3K ...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ATR	9.706e-70	50.22	ATR serine/threonine kinase [Source:NCBI gene;Acc:...	[more]
ATR	1.100e-69	50.22	ATR serine/threonine kinase [Source:NCBI gene;Acc:...	[more]
ATR	1.117e-69	50.22	ATR serine/threonine kinase [Source:NCBI gene;Acc:...	[more]
ATR	1.140e-69	50.22	ATR serine/threonine kinase [Source:NCBI gene;Acc:...	[more]
ATR	1.268e-69	50.22	ATR serine/threonine kinase [Source:NCBI gene;Acc:...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Atr	2.914e-70	48.97	ataxia telangiectasia and Rad3 related [Source:MGI...	[more]
Atr	3.030e-70	48.97	ataxia telangiectasia and Rad3 related [Source:MGI...	[more]
Atm	2.814e-38	35.65	ataxia telangiectasia mutated [Source:MGI Symbol;A...	[more]
Atm	2.841e-38	35.65	ataxia telangiectasia mutated [Source:MGI Symbol;A...	[more]
Smg1	1.816e-34	44.22	SMG1 homolog, phosphatidylinositol 3-kinase-relate...	[more]

BLAST of Serine/threonine-protein kinase atr vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9JKK8\|ATR_MOUSE	2.098e-69	48.97	Serine/threonine-protein kinase ATR OS=Mus musculu...	[more]
sp\|Q13535\|ATR_HUMAN	4.123e-69	48.15	Serine/threonine-protein kinase ATR OS=Homo sapien...	[more]
sp\|Q9DE14\|ATR_XENLA	1.707e-67	49.78	Serine/threonine-protein kinase atr OS=Xenopus lae...	[more]
sp\|Q9VXG8\|ATR_DROME	4.598e-58	42.98	Serine/threonine-protein kinase ATR OS=Drosophila ...	[more]
sp\|Q02099\|RAD3_SCHPO	2.793e-55	43.26	Protein kinase rad3 OS=Schizosaccharomyces pombe (...	[more]

BLAST of Serine/threonine-protein kinase atr vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
K9KAF3	2.681e-70	48.56	Serine/threonine-protein kinase ATR-like protein (...	[more]
S7MYI1	1.460e-69	48.56	Serine/threonine-protein kinase ATR OS=Myotis bran...	[more]
F7FJ30	6.023e-69	50.21	Uncharacterized protein OS=Ornithorhynchus anatinu...	[more]
A0A4W3HYM3	7.000e-69	51.09	Uncharacterized protein OS=Callorhinchus milii OX=...	[more]
A0A2I0TAT3	1.034e-68	49.57	Uncharacterized protein OS=Limosa lapponica baueri...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
atr	1.646e-68	51.30	ATR serine/threonine kinase [Source:ZFIN;Acc:ZDB-G...	[more]
atm	1.506e-38	35.22	ATM serine/threonine kinase [Source:ZFIN;Acc:ZDB-G...	[more]
atm	2.972e-38	35.22	ATM serine/threonine kinase [Source:ZFIN;Acc:ZDB-G...	[more]
smg1	3.892e-34	49.58	SMG1 nonsense mediated mRNA decay associated PI3K ...	[more]
mtor	7.916e-27	31.56	mechanistic target of rapamycin kinase [Source:NCB...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000003429.1	8.586e-61	46.12	pep scaffold:Pmarinus_7.0:GL476508:503342:564700:-...	[more]
ENSPMAT00000003412.1	8.678e-61	46.12	pep scaffold:Pmarinus_7.0:GL476508:503342:564700:-...	[more]
ENSPMAT00000003421.1	9.738e-61	46.12	pep scaffold:Pmarinus_7.0:GL476508:503342:564700:-...	[more]
ENSPMAT00000007186.1	5.125e-39	35.17	pep scaffold:Pmarinus_7.0:GL476459:175296:202639:-...	[more]
ENSPMAT00000002453.1	1.039e-8	30.07	pep scaffold:Pmarinus_7.0:GL482029:21191:33947:1 g...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
MEC1	8.234e-43	39.91	Genome integrity checkpoint protein and PI kinase ...	[more]
TEL1	2.065e-38	37.93	Protein kinase primarily involved in telomere leng...	[more]
TOR2	1.014e-27	31.25	PIK-related protein kinase and rapamycin target; s...	[more]
TOR1	1.031e-26	33.78	PIK-related protein kinase and rapamycin target; s...	[more]
PIK1	1.234e-9	26.26	Phosphatidylinositol 4-kinase; catalyzes first ste...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO29217	2.529e-59	45.79	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36404	1.497e-42	36.64	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48437	1.641e-30	47.41	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44977	3.115e-28	31.40	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34280	5.869e-16	25.51	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
atr	3.498e-63	47.06	ATR serine/threonine kinase [Source:NCBI gene;Acc:...	[more]
mtor	1.009e-26	30.74	mechanistic target of rapamycin kinase [Source:ZFI...	[more]
prkdc	6.609e-12	26.17	protein kinase, DNA-activated, catalytic subunit [...	[more]
si:rp71-17i16.5	2.118e-9	28.15	phosphatidylinositol 4,5-bisphosphate 3-kinase cat...	[more]
pik3cg	2.429e-8	26.32	phosphatidylinositol-4,5-bisphosphate 3-kinase cat...	[more]

BLAST of Serine/threonine-protein kinase atr vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000018015.1	1.075e-152	98.62	SMESG000018015.1	[more]
SMESG000018015.1	1.149e-152	98.62	SMESG000018015.1	[more]
SMESG000018015.1	1.239e-152	98.62	SMESG000018015.1	[more]
SMESG000009788.1	9.884e-25	40.34	SMESG000009788.1	[more]
SMESG000009788.1	1.027e-24	40.34	SMESG000009788.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30009778 ID=SMED30009778|Name=Serine/threonine-protein kinase atr|organism=Schmidtea mediterranea sexual|type=transcript|length=823bp
AGGGGAAAATCTGGTTTAATTGAATGGGTAAATAATACAGAAAGCTTCAG
ACAAGTTGTTGTCGATTTGCACATACAAAGAAACAATCCTATAATTTGGC
AAAAGCTTCACGCTCGTTATGCACAACGTGGTGATTCTTTTAAAAAAAAA
GTTAATGAAATTTACTAAAGAAGTATTGCCTTTATATCCAGTTGTATTCA
ATAAGTGGTTTCTTCAAAAGTTCCCTGAACCAAACGCGTGGTATAGGAGC
GTGCAAAAATATTGTCGATCTGTCGCCGTTATGAGTATGGTCGGTTACAT
TTTAGGTCTCGGTGACCGTCATATTGAAAACATTTTATTTGATCACACCA
GTGGTGATGTTGTCCATATTGATTATAATGGTCTTTTCAATCACGGTAAA
ACTTTGGAGTGGCCAGAAGTGGTTCCATTTAGATTAACGAGAAATATGCA
AGACGGACTTGGGCCATGTGGTGAAAATAATGGCCTATTCCGTTCTTCGT
GTGTTGCTACACTGAACTTACTCCGCAATGAAATCGAACCAATAATGGCA
GTATTCAAACCGATGTATTACGATACATTAACAGAAGTTAAAGATCCTCT
GATTAAATCGAATAAACAGAGTAATGCTGTTACAATGACTGAGAATAAAC
TGGAAGAAATGGAAAACCGTCTGAAAGGAAAAGTGAACCAGTTACCTTTG
TCGGTGGAAGGAGAAGTGAATTATTTGATTGCACAGGCTATTGATGAAAA
ATTACTGTGCCAAATGTATATGGGATGGGGTTCTTTTATATGAAATTGTG
TTGAATAAAATTATGTCTTGTAG

protein sequence of SMED30009778-orf-1

>SMED30009778-orf-1 ID=SMED30009778-orf-1|Name=SMED30009778-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=225bp
MHNVVILLKKKLMKFTKEVLPLYPVVFNKWFLQKFPEPNAWYRSVQKYCR
SVAVMSMVGYILGLGDRHIENILFDHTSGDVVHIDYNGLFNHGKTLEWPE
VVPFRLTRNMQDGLGPCGENNGLFRSSCVATLNLLRNEIEPIMAVFKPMY
YDTLTEVKDPLIKSNKQSNAVTMTENKLEEMENRLKGKVNQLPLSVEGEV
NYLIAQAIDEKLLCQMYMGWGSFI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0046982	protein heterodimerization activity
GO:0016301	kinase activity
GO:0005515	protein binding
GO:0032405	MutLalpha complex binding
GO:0032407	MutSalpha complex binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0000166	nucleotide binding
GO:0003677	DNA binding

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000014	zeta neoblast
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000403	PI3/4_kinase_cat_dom
IPR003152	FATC_dom
IPR018936	PI3/4_kinase_CS
IPR011009	Kinase-like_dom_sf

Vocabulary: **biological process**
Term	Definition
GO:0032212	positive regulation of telomere maintenance via telomerase
GO:0034644	cellular response to UV
GO:0043393	regulation of protein binding
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	protein autophosphorylation
GO:0051276	chromosome organization
GO:0070198	protein localization to chromosome, telomeric region
GO:0071480	cellular response to gamma radiation
GO:0090399	replicative senescence
GO:0097694	establishment of RNA localization to telomere
GO:1904884	positive regulation of telomerase catalytic core complex assembly
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007566	embryo implantation
GO:0008156	negative regulation of DNA replication
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0000077	DNA damage checkpoint