Serine/threonine kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30009769 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: TAOK3 (TAO kinase 3 [Source:HGNC Symbol;Acc:HGNC:18133]) HSP 1 Score: 347.051 bits (889), Expect = 1.319e-102 Identity = 164/319 (51.41%), Postives = 220/319 (68.97%), Query Frame = 2
Query: 140 LRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+R + K+ P+I+ LF DDP ++ L +IG G+FGAVY+A N T E+VAIK++ GK+ E W+DI +EV+FLR+L H N + YKGCYLK+ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L W+ F F+ LQK P +RP++ + L+ F R + VL +I RTK+AV + K++K+L+
Sbjct: 1 MRKGVLKD-PEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQT---HEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSN-EWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILF 313 HSP 2 Score: 124.02 bits (310), Expect = 5.473e-28 Identity = 80/251 (31.87%), Postives = 136/251 (54.18%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK E +I+KQ++D +Q KQ+K L+ +L N H K +L+ L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + L +RQ E+++FD + R+G N
Sbjct: 646 HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPK------NEH----KTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGN 886
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: TAOK3 (TAO kinase 3 [Source:HGNC Symbol;Acc:HGNC:18133]) HSP 1 Score: 347.051 bits (889), Expect = 1.319e-102 Identity = 164/319 (51.41%), Postives = 220/319 (68.97%), Query Frame = 2
Query: 140 LRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+R + K+ P+I+ LF DDP ++ L +IG G+FGAVY+A N T E+VAIK++ GK+ E W+DI +EV+FLR+L H N + YKGCYLK+ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L W+ F F+ LQK P +RP++ + L+ F R + VL +I RTK+AV + K++K+L+
Sbjct: 1 MRKGVLKD-PEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQT---HEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSN-EWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILF 313 HSP 2 Score: 124.02 bits (310), Expect = 5.473e-28 Identity = 80/251 (31.87%), Postives = 136/251 (54.18%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK E +I+KQ++D +Q KQ+K L+ +L N H K +L+ L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + L +RQ E+++FD + R+G N
Sbjct: 646 HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPK------NEH----KTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGN 886
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: TAOK1 (TAO kinase 1 [Source:HGNC Symbol;Acc:HGNC:29259]) HSP 1 Score: 343.969 bits (881), Expect = 5.922e-102 Identity = 166/323 (51.39%), Postives = 224/323 (69.35%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R K+ P+I+ LF +DP ++TDLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L WS +F +F+ S LQK P RP++ + L+ F VL +I RTK+AV + K++K+L+
Sbjct: 1 MPSTNRAGSLKD-PEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQST---EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLF 317 HSP 2 Score: 92.4337 bits (228), Expect = 3.212e-18 Identity = 86/295 (29.15%), Postives = 144/295 (48.81%), Query Frame = 2
Query: 2309 MLSQHEK-LQALEYKQKENL--HRLKMDQ---------------IKKQHDLEMENQLQYAAQEE--------AQIKKRHSHEVKNLPKYLKL--------KEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASS 3091
M QH+K L LE K K + HRL++D+ + K+H ME + + + EE AQ KK + +++ + KL KE +I+KQ++D IQ +Q+K LR L + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N V+S S +A S
Sbjct: 470 MRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKESKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKS----------EHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNM-VLSNLSPEAFS 753 HSP 3 Score: 62.003 bits (149), Expect = 6.012e-9 Identity = 43/131 (32.82%), Postives = 73/131 (55.73%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEIKSAKKNAKSE 2137
+FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+KQL LE + E + + L++D + R N E+EKL HQ +EK K ++N E + + +A K E+ S ++ K E
Sbjct: 437 HFATIRTASLV------TRQMQEH---EQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKRE 558
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: TAOK1 (TAO kinase 1 [Source:HGNC Symbol;Acc:HGNC:29259]) HSP 1 Score: 345.895 bits (886), Expect = 2.334e-101 Identity = 166/323 (51.39%), Postives = 224/323 (69.35%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R K+ P+I+ LF +DP ++TDLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L WS +F +F+ S LQK P RP++ + L+ F VL +I RTK+AV + K++K+L+
Sbjct: 1 MPSTNRAGSLKD-PEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQST---EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLF 317 HSP 2 Score: 157.918 bits (398), Expect = 1.680e-38 Identity = 147/485 (30.31%), Postives = 251/485 (51.75%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEI-----------KSAKKNAKSESGSN-----------------NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASS 3091
+FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+KQL LE + E + + L++D + R N E+EKL HQ +EK K ++N E + + +A K E+ K K+ K E N NIQ L+ R++ +E R+ KR LL NLE+ E++ ++ Q + E+A++L QHE +Q LE++ + +++ + I+ QH E+ NQL+Y + E +++++H EV+ PK LK KE +I+KQ++D IQ +Q+K LR L + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N V+S S +A S
Sbjct: 437 HFATIRTASLV------TRQMQEH---EQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKS----------EHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNM-VLSNLSPEAFS 901
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: TAOK2 (TAO kinase 2 [Source:HGNC Symbol;Acc:HGNC:16835]) HSP 1 Score: 344.354 bits (882), Expect = 2.102e-100 Identity = 164/323 (50.77%), Postives = 226/323 (69.97%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R K+ PD++ LF DDP +++DLR+IG G+FGAVY+AR++ E+VAIK++ GK+ E W+DI +EVRFL++L H N + Y+GCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA V L GL YLH + IHRD+KA NIL+++ G +K+GDFGS S ++PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L +WS +F +F+ S LQK P RP++ L+ F V+ +I RTK+AV + K++K+L+
Sbjct: 1 MPAGGRAGSLKD-PDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSN---EKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPVLQSG-HWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILF 317 HSP 2 Score: 120.168 bits (300), Expect = 1.054e-26 Identity = 80/250 (32.00%), Postives = 137/250 (54.80%), Query Frame = 2
Query: 2303 ALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
AL+L QHE + LE +Q + + R + + + QH E+ NQL+Y + E +++++H+ +V+ PK LK KE +I+KQ+++ IQ +Q+K LR L A K LL+ L++E+ RK A L QY+ SI + Q ++D TQ E L++E +L+ +Q + + H + L+ R+A R+ALLE ++++ Q R + +L +RQA E+++FD + RLG +
Sbjct: 678 ALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKA----------QHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSS 917
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: kin-18 (Serine/threonine-protein kinase SULU [Source:UniProtKB/Swiss-Prot;Acc:P46549]) HSP 1 Score: 297.745 bits (761), Expect = 3.211e-91 Identity = 147/324 (45.37%), Postives = 214/324 (66.05%), Query Frame = 2
Query: 143 RPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLN------WSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+P + K+ P I++LF+N DP Y DLR+IG G+FGAVY+A + ++ VAIK++ GK+ E W DI +EV FL + H + + YK C+LKD WLVM+YC+GS ADI++V ++ +RE EIA + ++ L L+YLH IHRDIKA NIL++D +K+ DFGS S + PA +F+GTPF++APEVILAM+ G Y ++ D+WSLGITCIE+AE PP F +N M+A+Y IA ND P L+ P++ WS+ F F+ L+K ++R SA + + PF + + D + ++I RTKN V + K+RK++Y
Sbjct: 8 KPGVIKD-PSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAV---EKWNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLF-SMNAMSALYHIAQNDPPTLS-PIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMY 325
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: kin-18 (Serine/threonine-protein kinase SULU [Source:UniProtKB/Swiss-Prot;Acc:P46549]) HSP 1 Score: 297.745 bits (761), Expect = 3.211e-91 Identity = 147/324 (45.37%), Postives = 214/324 (66.05%), Query Frame = 2
Query: 143 RPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLN------WSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+P + K+ P I++LF+N DP Y DLR+IG G+FGAVY+A + ++ VAIK++ GK+ E W DI +EV FL + H + + YK C+LKD WLVM+YC+GS ADI++V ++ +RE EIA + ++ L L+YLH IHRDIKA NIL++D +K+ DFGS S + PA +F+GTPF++APEVILAM+ G Y ++ D+WSLGITCIE+AE PP F +N M+A+Y IA ND P L+ P++ WS+ F F+ L+K ++R SA + + PF + + D + ++I RTKN V + K+RK++Y
Sbjct: 8 KPGVIKD-PSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAV---EKWNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLF-SMNAMSALYHIAQNDPPTLS-PIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMY 325
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: kin-18 (Serine/threonine-protein kinase SULU [Source:UniProtKB/Swiss-Prot;Acc:P46549]) HSP 1 Score: 313.923 bits (803), Expect = 2.002e-90 Identity = 147/324 (45.37%), Postives = 214/324 (66.05%), Query Frame = 2
Query: 143 RPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLN------WSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+P + K+ P I++LF+N DP Y DLR+IG G+FGAVY+A + ++ VAIK++ GK+ E W DI +EV FL + H + + YK C+LKD WLVM+YC+GS ADI++V ++ +RE EIA + ++ L L+YLH IHRDIKA NIL++D +K+ DFGS S + PA +F+GTPF++APEVILAM+ G Y ++ D+WSLGITCIE+AE PP F +N M+A+Y IA ND P L+ P++ WS+ F F+ L+K ++R SA + + PF + + D + ++I RTKN V + K+RK++Y
Sbjct: 8 KPGVIKD-PSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAV---EKWNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLF-SMNAMSALYHIAQNDPPTLS-PIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMY 325 HSP 2 Score: 92.0485 bits (227), Expect = 1.655e-18 Identity = 69/248 (27.82%), Postives = 132/248 (53.23%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLG 3043
+ L+ QHE + LE + LH +K ++ QH+ E +Q +Y +++ +++K+H+ + + P+ LK++E +IRKQYR Q +QFK+ + ++ + +K+L L+ ++ +K A L SQYE+ I + + + K++S Q E + LEKE L +Q+ + +++ ++ AL++RI R+A+LE I ++ ++ RR+ + DR + E +NH R G
Sbjct: 722 HGLLSKQHEMTRDLEIQHLNELHAMKKRHLETQHEAESASQNEYTQRQQDELRKKHAMQSRQQPRDLKIQEAQIRKQYRQVVKTQTRQFKLYLTQMVQVVPKD----------EQKELTSRLKQDQMQKVALLASQYESQIKKMVQDKTVKLESWQEDEQRVLSEKLEKELEELIAYQKKTRATLEEQIKKERTALEERIGTRRAMLEQKIIEEREQMGEMRRLKKEQIRDRHSQERHRLENHFVRTG 959 HSP 3 Score: 51.9878 bits (123), Expect = 2.689e-6 Identity = 52/182 (28.57%), Postives = 86/182 (47.25%), Query Frame = 2
Query: 1586 STGDVSESKTSMI-----SPSRIMPGQISQQPLIENMIS------HLDISDPSVLYP------PPGAGTSNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWR------EQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLE 2062
S G V S T++ SPS +P + QP ++ S H D D S+ P P A ATL+ +H F+ +R+ Q+Q ++ EQM+ K LR H K+L+Q EER A++ E L+ ++R+ + ++KE ++ +L+KRKK++ + E
Sbjct: 436 SHGSVGASITAIAVNPTPSPSEPIP---TSQPTSKSESSSILETAHDDPLDTSIRAPVKDLHMPHRAVKERIATLQ-------NHKFATLRSQRIINQEQEEYTKENNMYEQMSKYKHLRQAHHKELQQFEERCALDREQLRVKMDRELEQLTTTYSKEKMRVRCSQNNELDKRKKDIEDGE 607
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: kin-18 (Serine/threonine-protein kinase SULU [Source:UniProtKB/Swiss-Prot;Acc:P46549]) HSP 1 Score: 313.923 bits (803), Expect = 2.002e-90 Identity = 147/324 (45.37%), Postives = 214/324 (66.05%), Query Frame = 2
Query: 143 RPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLN------WSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+P + K+ P I++LF+N DP Y DLR+IG G+FGAVY+A + ++ VAIK++ GK+ E W DI +EV FL + H + + YK C+LKD WLVM+YC+GS ADI++V ++ +RE EIA + ++ L L+YLH IHRDIKA NIL++D +K+ DFGS S + PA +F+GTPF++APEVILAM+ G Y ++ D+WSLGITCIE+AE PP F +N M+A+Y IA ND P L+ P++ WS+ F F+ L+K ++R SA + + PF + + D + ++I RTKN V + K+RK++Y
Sbjct: 8 KPGVIKD-PSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAV---EKWNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLF-SMNAMSALYHIAQNDPPTLS-PIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMY 325 HSP 2 Score: 92.0485 bits (227), Expect = 1.655e-18 Identity = 69/248 (27.82%), Postives = 132/248 (53.23%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLG 3043
+ L+ QHE + LE + LH +K ++ QH+ E +Q +Y +++ +++K+H+ + + P+ LK++E +IRKQYR Q +QFK+ + ++ + +K+L L+ ++ +K A L SQYE+ I + + + K++S Q E + LEKE L +Q+ + +++ ++ AL++RI R+A+LE I ++ ++ RR+ + DR + E +NH R G
Sbjct: 722 HGLLSKQHEMTRDLEIQHLNELHAMKKRHLETQHEAESASQNEYTQRQQDELRKKHAMQSRQQPRDLKIQEAQIRKQYRQVVKTQTRQFKLYLTQMVQVVPKD----------EQKELTSRLKQDQMQKVALLASQYESQIKKMVQDKTVKLESWQEDEQRVLSEKLEKELEELIAYQKKTRATLEEQIKKERTALEERIGTRRAMLEQKIIEEREQMGEMRRLKKEQIRDRHSQERHRLENHFVRTG 959 HSP 3 Score: 51.9878 bits (123), Expect = 2.689e-6 Identity = 52/182 (28.57%), Postives = 86/182 (47.25%), Query Frame = 2
Query: 1586 STGDVSESKTSMI-----SPSRIMPGQISQQPLIENMIS------HLDISDPSVLYP------PPGAGTSNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWR------EQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLE 2062
S G V S T++ SPS +P + QP ++ S H D D S+ P P A ATL+ +H F+ +R+ Q+Q ++ EQM+ K LR H K+L+Q EER A++ E L+ ++R+ + ++KE ++ +L+KRKK++ + E
Sbjct: 436 SHGSVGASITAIAVNPTPSPSEPIP---TSQPTSKSESSSILETAHDDPLDTSIRAPVKDLHMPHRAVKERIATLQ-------NHKFATLRSQRIINQEQEEYTKENNMYEQMSKYKHLRQAHHKELQQFEERCALDREQLRVKMDRELEQLTTTYSKEKMRVRCSQNNELDKRKKDIEDGE 607
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: cst-2 (Caenorhabditis STE20-like kinase [Source:UniProtKB/TrEMBL;Acc:Q304D8]) HSP 1 Score: 197.593 bits (501), Expect = 8.817e-55 Identity = 108/299 (36.12%), Postives = 167/299 (55.85%), Query Frame = 2
Query: 191 NDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYC-LGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPA----NSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMS 1072
N P ++ + ++G G++G+V+ A + + ++AIK++ VD D ++I +E+ +++ K + Y G Y K + W+VM+YC GS++DI+ ++ L E EI+ V+ + L GLQYLH IHRDIKA NIL+ G K+ DFG ++ N+ +GTPFW+APEVI E Y+ K D+WSLGIT IEMAE PPY ++PM A++ I + P P WS FN F+ S L K P++R +A + F +N D++ MI + + M+
Sbjct: 28 NKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDT--------DLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---EEIGYDTKADIWSLGITAIEMAEGRPPY-SDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFIKNAPGCDIMQLMIQDAQEKAILGQAPMA 314
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Tao (gene:FBgn0031030 transcript:FBtr0336691) HSP 1 Score: 355.14 bits (910), Expect = 1.160e-104 Identity = 174/322 (54.04%), Postives = 226/322 (70.19%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKML 1093
MP RP K+ P+I+ LF DP I+ DLR+IG G+FGAVYYAR T+EIVAIK++ GK+ +E W+DI +E+RFLR+L+H N + YKGCYL++ AWLVM+YC+GS +DI+EVHK+ L E EIA + VL GL YLH G IHRDIKA NIL+TD G +K+ DFGS + PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PPYF +N M+A+Y IA N+SP L P +WS F SF+ L+K P +RPS+ L + S VL ++IARTK+AV + K++K+L
Sbjct: 1 MPSA-RPGSLKD-PEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQS---QEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYF-NMNAMSALYHIAQNESPTL--PNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKIL 314 HSP 2 Score: 136.346 bits (342), Expect = 4.319e-32 Identity = 85/262 (32.44%), Postives = 148/262 (56.49%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQA 3085
+A++L HEK Q LEY+Q++++H+L+ +QI KQHD E+ NQ Y + + ++ ++H+ E++ PK LK KE +IRKQ+R+ Q KQ+K R A V +K++++ L++E+ RK L QYE SI + + Q+ K+D +Q+ E + H+ LE E ML+ +Q ++ Q+ + L++R++ R+ LLE + + +F R L ++ EL++FDN + LG ++ SR+A
Sbjct: 759 HAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKTQTKQYK----------RYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFSTLSLIE-VSREA 1009
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Tao (gene:FBgn0031030 transcript:FBtr0303999) HSP 1 Score: 352.829 bits (904), Expect = 8.368e-104 Identity = 175/323 (54.18%), Postives = 226/323 (69.97%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLN-WSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKML 1093
MP RP K+ P+I+ LF DP I+ DLR+IG G+FGAVYYAR T+EIVAIK++ GK+ +E W+DI +E+RFLR+L+H N + YKGCYL++ AWLVM+YC+GS +DI+EVHK+ L E EIA + VL GL YLH G IHRDIKA NIL+TD G +K+ DFGS + PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PPYF +N M+A+Y IA N+SP L P N WS F SF+ L+K P +RPS+ L + S VL ++IARTK+AV + K++K+L
Sbjct: 1 MPSA-RPGSLKD-PEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQS---QEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYF-NMNAMSALYHIAQNESPTL--PKNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKIL 315 HSP 2 Score: 136.346 bits (342), Expect = 4.753e-32 Identity = 85/262 (32.44%), Postives = 148/262 (56.49%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQA 3085
+A++L HEK Q LEY+Q++++H+L+ +QI KQHD E+ NQ Y + + ++ ++H+ E++ PK LK KE +IRKQ+R+ Q KQ+K R A V +K++++ L++E+ RK L QYE SI + + Q+ K+D +Q+ E + H+ LE E ML+ +Q ++ Q+ + L++R++ R+ LLE + + +F R L ++ EL++FDN + LG ++ SR+A
Sbjct: 760 HAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKTQTKQYK----------RYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFSTLSLIE-VSREA 1010
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Tao (gene:FBgn0031030 transcript:FBtr0074772) HSP 1 Score: 352.829 bits (904), Expect = 8.368e-104 Identity = 175/323 (54.18%), Postives = 226/323 (69.97%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLN-WSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKML 1093
MP RP K+ P+I+ LF DP I+ DLR+IG G+FGAVYYAR T+EIVAIK++ GK+ +E W+DI +E+RFLR+L+H N + YKGCYL++ AWLVM+YC+GS +DI+EVHK+ L E EIA + VL GL YLH G IHRDIKA NIL+TD G +K+ DFGS + PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PPYF +N M+A+Y IA N+SP L P N WS F SF+ L+K P +RPS+ L + S VL ++IARTK+AV + K++K+L
Sbjct: 1 MPSA-RPGSLKD-PEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQS---QEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYF-NMNAMSALYHIAQNESPTL--PKNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKIL 315 HSP 2 Score: 136.346 bits (342), Expect = 4.753e-32 Identity = 85/262 (32.44%), Postives = 148/262 (56.49%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQA 3085
+A++L HEK Q LEY+Q++++H+L+ +QI KQHD E+ NQ Y + + ++ ++H+ E++ PK LK KE +IRKQ+R+ Q KQ+K R A V +K++++ L++E+ RK L QYE SI + + Q+ K+D +Q+ E + H+ LE E ML+ +Q ++ Q+ + L++R++ R+ LLE + + +F R L ++ EL++FDN + LG ++ SR+A
Sbjct: 760 HAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKTQTKQYK----------RYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFSTLSLIE-VSREA 1010
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Tao (gene:FBgn0031030 transcript:FBtr0074771) HSP 1 Score: 352.829 bits (904), Expect = 8.368e-104 Identity = 175/323 (54.18%), Postives = 226/323 (69.97%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLN-WSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKML 1093
MP RP K+ P+I+ LF DP I+ DLR+IG G+FGAVYYAR T+EIVAIK++ GK+ +E W+DI +E+RFLR+L+H N + YKGCYL++ AWLVM+YC+GS +DI+EVHK+ L E EIA + VL GL YLH G IHRDIKA NIL+TD G +K+ DFGS + PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PPYF +N M+A+Y IA N+SP L P N WS F SF+ L+K P +RPS+ L + S VL ++IARTK+AV + K++K+L
Sbjct: 1 MPSA-RPGSLKD-PEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQS---QEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYF-NMNAMSALYHIAQNESPTL--PKNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKIL 315 HSP 2 Score: 136.346 bits (342), Expect = 4.753e-32 Identity = 85/262 (32.44%), Postives = 148/262 (56.49%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQA 3085
+A++L HEK Q LEY+Q++++H+L+ +QI KQHD E+ NQ Y + + ++ ++H+ E++ PK LK KE +IRKQ+R+ Q KQ+K R A V +K++++ L++E+ RK L QYE SI + + Q+ K+D +Q+ E + H+ LE E ML+ +Q ++ Q+ + L++R++ R+ LLE + + +F R L ++ EL++FDN + LG ++ SR+A
Sbjct: 760 HAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKTQTKQYK----------RYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFSTLSLIE-VSREA 1010
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Tao (gene:FBgn0031030 transcript:FBtr0336692) HSP 1 Score: 336.65 bits (862), Expect = 5.000e-102 Identity = 173/318 (54.40%), Postives = 223/318 (70.13%), Query Frame = 2
Query: 143 RPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLN-WSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKML 1093
RP K+ P+I+ LF DP I+ DLR+IG G+FGAVYYAR T+EIVAIK++ GK +E W+DI +E+RFLR+L+H N + YKGCYL++ AWLVM+YC+GS +DI+EVHK+ L E EIA + VL GL YLH G IHRDIKA NIL+TD G +K+ DFGS + PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PPYF +N M+A+Y IA N+SP L P N WS F SF+ L+K P +RPS+ L + S VL ++IARTK+AV + K++K+L
Sbjct: 5 RPGSLKD-PEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGK---QSQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYF-NMNAMSALYHIAQNESPTL--PKNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKIL 315
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: taok3a (TAO kinase 3a [Source:ZFIN;Acc:ZDB-GENE-100921-50]) HSP 1 Score: 349.362 bits (895), Expect = 1.000e-103 Identity = 168/323 (52.01%), Postives = 220/323 (68.11%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R K+ P+ ++LF DDP ++ DL +IG G+FGAVY+ARN + E+VAIK++ +GK+ E W+DI +EV+FL +L H N + YKGCYLKD AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRD+KA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L WS F SF+ L K P RPS+ + L+ F R + VL +I RTK+AV + K++K+LY
Sbjct: 2 MPTSTRKGAVKD-PEFANLFFKDDPEEVFCDLHEIGHGSFGAVYFARNSYSNEVVAIKKMSYNGKQTT---EKWQDIIKEVKFLEQLRHPNTIEYKGCYLKDNTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALLGLAYLHSHNMIHRDVKAGNILLTEPGQVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYEGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSN-EWSDAFRSFVDYCLLKIPQDRPSSAELLRHEFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILY 318 HSP 2 Score: 135.191 bits (339), Expect = 1.114e-31 Identity = 134/447 (29.98%), Postives = 227/447 (50.78%), Query Frame = 2
Query: 1826 QKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKELTN-LETQTLRKWEADTKGEIK-------SAKKNAKSESGSN---NIQ--------ELIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+++ + REQM+G KR+R QH+KQL LE + E + + L ++ + N ELEKL H + +K +KKELT L+TQ +K K +IK S K K E S NIQ +L+ +++ + R KR+ +++ E++Q E++ ++ Q E E+A+++ Q E Q LE++Q + L +L+MD I+ QH E+ENQ++Y + E ++ ++H E++ PK LK E +I+KQ++D +Q KQ+K LR +L + K +L+ L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ +++ R+A LE I+++ Q R + L DRQ E+ +FD + R+G +N
Sbjct: 450 EQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKELETHANNAFIELEKLAKKHAIQTDKEMKTLSADEKKFQQQIVAQQKKELTTFLDTQ--KKQYKLCKEKIKEEMSEDHSTPKKEKQERLSKHKENIQHSQAEEEAQLLGQQRAFYDRNCRAFKRKIMIKRHEFEQEQLREELNKKKTQKEMEHAMLIRQDESTQELEHRQLKTLQKLRMDLIRLQHQTELENQIEYNNRRERELHRKHVLELRQQPKNLKAMELQIKKQFQDTCKVQTKQYKALRHHQLEVTPKS----------EHKTVLKALKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRQQLQQEMELLNAYQSKIKIQTEAQHEREQQKLEQKVSLRRAHLEQKIEEELASLQKERTDRIKHLLDRQEREIDAFDMESLRMGFNN 884
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: taok3a (TAO kinase 3a [Source:ZFIN;Acc:ZDB-GENE-100921-50]) HSP 1 Score: 349.747 bits (896), Expect = 1.068e-103 Identity = 168/323 (52.01%), Postives = 220/323 (68.11%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R K+ P+ ++LF DDP ++ DL +IG G+FGAVY+ARN + E+VAIK++ +GK+ E W+DI +EV+FL +L H N + YKGCYLKD AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRD+KA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L WS F SF+ L K P RPS+ + L+ F R + VL +I RTK+AV + K++K+LY
Sbjct: 2 MPTSTRKGAVKD-PEFANLFFKDDPEEVFCDLHEIGHGSFGAVYFARNSYSNEVVAIKKMSYNGKQTT---EKWQDIIKEVKFLEQLRHPNTIEYKGCYLKDNTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALLGLAYLHSHNMIHRDVKAGNILLTEPGQVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYEGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSN-EWSDAFRSFVDYCLLKIPQDRPSSAELLRHEFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILY 318 HSP 2 Score: 135.961 bits (341), Expect = 6.624e-32 Identity = 134/447 (29.98%), Postives = 227/447 (50.78%), Query Frame = 2
Query: 1826 QKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKELTN-LETQTLRKWEADTKGEIK-------SAKKNAKSESGSN---NIQ--------ELIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+++ + REQM+G KR+R QH+KQL LE + E + + L ++ + N ELEKL H + +K +KKELT L+TQ +K K +IK S K K E S NIQ +L+ +++ + R KR+ +++ E++Q E++ ++ Q E E+A+++ Q E Q LE++Q + L +L+MD I+ QH E+ENQ++Y + E ++ ++H E++ PK LK E +I+KQ++D +Q KQ+K LR +L + K +L+ L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ +++ R+A LE I+++ Q R + L DRQ E+ +FD + R+G +N
Sbjct: 457 EQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKELETHANNAFIELEKLAKKHAIQTDKEMKTLSADEKKFQQQIVAQQKKELTTFLDTQ--KKQYKLCKEKIKEEMSEDHSTPKKEKQERLSKHKENIQHSQAEEEAQLLGQQRAFYDRNCRAFKRKIMIKRHEFEQEQLREELNKKKTQKEMEHAMLIRQDESTQELEHRQLKTLQKLRMDLIRLQHQTELENQIEYNNRRERELHRKHVLELRQQPKNLKAMELQIKKQFQDTCKVQTKQYKALRHHQLEVTPKS----------EHKTVLKALKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRQQLQQEMELLNAYQSKIKIQTEAQHEREQQKLEQKVSLRRAHLEQKIEEELASLQKERTDRIKHLLDRQEREIDAFDMESLRMGFNN 891
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: taok1b (TAO kinase 1b [Source:ZFIN;Acc:ZDB-GENE-141024-1]) HSP 1 Score: 350.132 bits (897), Expect = 5.719e-103 Identity = 167/329 (50.76%), Postives = 224/329 (68.09%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLYH-CGNG 1111
MP R K+ P I+ LF +DP +++DLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ +F +F+ S LQK P RP + D LQ F VL +I RTK+AV + K++K+L+ NG
Sbjct: 1 MPSTSRAGCLKD-PKIADLFFKEDPEKLFSDLREIGHGSFGAVYFARDVRTSEVVAIKKMLYSGKQSN---EKWQDIIKEVKFLQRIQHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSS-EWTDYFRNFIDSCLQKIPKDRPHSKDLLQHAFVLRERPHSVLVDLILRTKDAVRELDNLQYRKMKKLLFQEAHNG 323 HSP 2 Score: 144.436 bits (363), Expect = 1.763e-34 Identity = 145/491 (29.53%), Postives = 253/491 (51.53%), Query Frame = 2
Query: 1727 PGAGTSNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKELTN-LETQT----LRKWEADTK-GEIKSAKKNAKSESGSN---NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASS 3091
P +FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+KQL LE + E + + L+++ + R + E+EKL +Q +K +KKEL++ LE+Q LRK + + E +S K K E S N Q L+ R++ ++E R+ KR L N+E+ E+I ++ Q + E+A++L HE +Q LE +Q +H+++ + I+ QH E+ NQL+Y + E +++++H EV+ PK LK KE +I+KQ++D IQ +Q+K LR L + + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q E L++E +L+ +Q + H + L+ R++ R+ALLE I+++ QN R + +L ++QA E+++FD+ + RLG N + S S + S
Sbjct: 431 PSRNREHFATIRTASLV------TRQMQEH---EQDSELREQMSGYKRMRRQHQKQLMALENKLKGEMDEHRLKLDKELEAQRNSFAAEMEKLMKKNQATTDKDAKLFANDEKKFHQHIQAQQKKELSSFLESQKREYKLRKEQLKEELNEKQSTPKKEKQELLSKQKENFQNYQAEEEANLLRRQRQYLDLESRRFKRRILTAKHNVEQDTLREEINKRQTQKDLEHAMLLRHHESMQELEVRQLGTIHKMRTELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKS----------DHKAVLKRLKEEQTRKLAILAEQYDHSINDMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQTDAQHERERKELEQRVSLRRALLEQKIEEEMVALQNERSERIRSLLEKQAREIEAFDSESMRLGFSNMMLTSLFSSDSHS 902
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: taok1a (TAO kinase 1a [Source:ZFIN;Acc:ZDB-GENE-130103-9]) HSP 1 Score: 346.665 bits (888), Expect = 1.237e-101 Identity = 164/323 (50.77%), Postives = 225/323 (69.66%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP +R K+ PDI+ LF +DP +++DLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGIT IE+AE +PP F +N M+A+Y IA N+SP L W+ +F +F+ S LQK P RP + + L+ F + VL +I RTK+AV + S K++K+L+
Sbjct: 1 MPNAVRAGSLKD-PDIADLFFKEDPERLFSDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYSGKQSN---EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSTSDLLEVHKKPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITSIELAERKPPLF-NMNAMSALYHIAQNESPSLQSS-EWTDYFRNFVDSCLQKLPQDRPHSEELLKHAFVQRERPESVLIDLIQRTKDAVRELDNLQSRKMKKILF 317 HSP 2 Score: 149.443 bits (376), Expect = 5.234e-36 Identity = 141/489 (28.83%), Postives = 253/489 (51.74%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEI-----------KSAKKNAKSESGSN-----------------NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQ---RLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASSS 3094
+FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+K L LE + E + + L+++ +N R + E++KL HQ +EK K N E + L+ ++ K E+ K K+ K E N NIQ L+ R++ +E R+ KR L+ N+E+ E++ ++ Q + E+A++L HE +Q LE++ + +++ +QI+ QH E+ NQL+Y + E +++++H EV+ PK LK KE +I+KQ++DA IQ +Q+K LR L + K +L+ L++E+ RK A L QY+++I+ + Q ++D Q E L++E +L+ +Q ++Q + Q+ + L+ R++ R+ALLET I+++ QN R + +L +RQA E+++FD+ + RLG N + + + S S
Sbjct: 440 HFATIRTASLV------TRQIQEH---EQDSEVREQMSGYKRMRRQHQKHLLALENKLKGEMDEHRLKLDKELENQRNSFAAEMDKLIKKHQGTMEKDAKTFANDEKKFLQHIQSQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRILIARHNVEQDLMREELNKRQTQKDLEHAMLLRHHESMQELEFRHLGTIQKMRAEQIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDACKIQTRQYKALRNHLLESTPKP----------EHKTMLKRLKEEQTRKLAILAEQYDHTINNMLSTQALRLDEAQEAECQVLRMQLQQELELLNAYQSKIKMQTDAQQE---RERKELEQRVSLRRALLETKIEEEMLTLQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLANISPEGLSHS 906
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: taok1a (TAO kinase 1a [Source:ZFIN;Acc:ZDB-GENE-130103-9]) HSP 1 Score: 346.665 bits (888), Expect = 1.237e-101 Identity = 164/323 (50.77%), Postives = 225/323 (69.66%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP +R K+ PDI+ LF +DP +++DLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGIT IE+AE +PP F +N M+A+Y IA N+SP L W+ +F +F+ S LQK P RP + + L+ F + VL +I RTK+AV + S K++K+L+
Sbjct: 1 MPNAVRAGSLKD-PDIADLFFKEDPERLFSDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYSGKQSN---EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSTSDLLEVHKKPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITSIELAERKPPLF-NMNAMSALYHIAQNESPSLQSS-EWTDYFRNFVDSCLQKLPQDRPHSEELLKHAFVQRERPESVLIDLIQRTKDAVRELDNLQSRKMKKILF 317 HSP 2 Score: 149.443 bits (376), Expect = 5.234e-36 Identity = 141/489 (28.83%), Postives = 253/489 (51.74%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEI-----------KSAKKNAKSESGSN-----------------NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQ---RLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASSS 3094
+FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+K L LE + E + + L+++ +N R + E++KL HQ +EK K N E + L+ ++ K E+ K K+ K E N NIQ L+ R++ +E R+ KR L+ N+E+ E++ ++ Q + E+A++L HE +Q LE++ + +++ +QI+ QH E+ NQL+Y + E +++++H EV+ PK LK KE +I+KQ++DA IQ +Q+K LR L + K +L+ L++E+ RK A L QY+++I+ + Q ++D Q E L++E +L+ +Q ++Q + Q+ + L+ R++ R+ALLET I+++ QN R + +L +RQA E+++FD+ + RLG N + + + S S
Sbjct: 440 HFATIRTASLV------TRQIQEH---EQDSEVREQMSGYKRMRRQHQKHLLALENKLKGEMDEHRLKLDKELENQRNSFAAEMDKLIKKHQGTMEKDAKTFANDEKKFLQHIQSQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRILIARHNVEQDLMREELNKRQTQKDLEHAMLLRHHESMQELEFRHLGTIQKMRAEQIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDACKIQTRQYKALRNHLLESTPKP----------EHKTMLKRLKEEQTRKLAILAEQYDHTINNMLSTQALRLDEAQEAECQVLRMQLQQELELLNAYQSKIKMQTDAQQE---RERKELEQRVSLRRALLETKIEEEMLTLQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLANISPEGLSHS 906
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: cirbp (cold inducible RNA binding protein [Source:Xenbase;Acc:XB-GENE-492781]) HSP 1 Score: 347.436 bits (890), Expect = 4.034e-103 Identity = 163/310 (52.58%), Postives = 215/310 (69.35%), Query Frame = 2
Query: 167 PDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
PDI+ LF +DP I+ DL +IG G+FGAVY+A N +T E+VAIK++ GK+ E W+DI +EV+FL++L H N + YKGCYLKD AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y K+D+WSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ F F+ LQK P +RP++ + LQ F R VL +I RTK+AV + K++K+L+
Sbjct: 16 PDIADLFCKEDPERIFVDLHEIGHGSFGAVYFATNSTTNEVVAIKKMSYSGKQMN---EKWQDIVKEVKFLQQLQHPNTIEYKGCYLKDHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASKSSPANSFVGTPYWMAPEVILAMDEGQYEGKIDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWTDSFKGFVDYCLQKIPQERPTSLELLQHDFVRRERPPRVLIDLIQRTKDAVRELDNLQYRKMKKILF 320 HSP 2 Score: 127.487 bits (319), Expect = 3.509e-29 Identity = 79/251 (31.47%), Postives = 139/251 (55.38%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q + L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK+ E +I+KQ++D +Q KQ+K L+ +L + K +L++L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + LF+RQ E+++FD + R+G N
Sbjct: 611 HAMLIRHDESTRELEYRQLQMLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKVMEMQIKKQFQDTCKVQTKQYKALKNHQLEV----------SPKCEHKTILKSLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRQQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKHLFERQEREIETFDMESLRMGFGN 851
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: cirbp (cold inducible RNA binding protein [Source:Xenbase;Acc:XB-GENE-492781]) HSP 1 Score: 348.206 bits (892), Expect = 5.416e-103 Identity = 165/319 (51.72%), Postives = 220/319 (68.97%), Query Frame = 2
Query: 140 LRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+R + K+ PDI+ LF +DP I+ DL +IG G+FGAVY+A N +T E+VAIK++ GK+ E W+DI +EV+FL++L H N + YKGCYLKD AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y K+D+WSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ F F+ LQK P +RP++ + LQ F R VL +I RTK+AV + K++K+L+
Sbjct: 10 MRRGLLKD-PDIADLFCKEDPERIFVDLHEIGHGSFGAVYFATNSTTNEVVAIKKMSYSGKQMN---EKWQDIVKEVKFLQQLQHPNTIEYKGCYLKDHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASKSSPANSFVGTPYWMAPEVILAMDEGQYEGKIDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWTDSFKGFVDYCLQKIPQERPTSLELLQHDFVRRERPPRVLIDLIQRTKDAVRELDNLQYRKMKKILF 322 HSP 2 Score: 130.568 bits (327), Expect = 4.724e-30 Identity = 82/265 (30.94%), Postives = 143/265 (53.96%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASSS 3094
+A+++ E + LEY+Q + L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK+ E +I+KQ++D +Q KQ+K L+ +L + K +L++L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + LF+RQ E+++FD + R+G N V Q +S
Sbjct: 613 HAMLIRHDESTRELEYRQLQMLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKVMEMQIKKQFQDTCKVQTKQYKALKNHQLEV----------SPKCEHKTILKSLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRQQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKHLFERQEREIETFDMESLRMGFGNLVTVPLGKSQHGAS 867
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: cirbp (cold inducible RNA binding protein [Source:Xenbase;Acc:XB-GENE-492781]) HSP 1 Score: 347.051 bits (889), Expect = 6.839e-103 Identity = 164/319 (51.41%), Postives = 220/319 (68.97%), Query Frame = 2
Query: 140 LRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+R + K+ PDI+ LF +DP I+ DL +IG G+FGAVY+A N +T E+VAIK++ GK+ E W+DI +EV+FL++L H N + YKGCYLKD AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y K+D+WSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ F F+ LQK P +RP++ + L+ F R VL +I RTK+AV + K++K+L+
Sbjct: 10 MRRGLLKD-PDIADLFCKEDPERIFVDLHEIGHGSFGAVYFATNSTTNEVVAIKKMSYSGKQMN---EKWQDIVKEVKFLQQLQHPNTIEYKGCYLKDHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASKSSPANSFVGTPYWMAPEVILAMDEGQYEGKIDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWTDSFKGFVDYCLQKIPQERPTSLELLRHDFVRRERPPRVLIDLIQRTKDAVRELDNLQYRKMKKILF 322 HSP 2 Score: 127.487 bits (319), Expect = 4.010e-29 Identity = 79/251 (31.47%), Postives = 139/251 (55.38%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q + L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK+ E +I+KQ++D +Q KQ+K L+ +L + K +L++L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + LF+RQ E+++FD + R+G N
Sbjct: 613 HAMLIRHDESTRELEYRQLQMLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKVMEMQIKKQFQDTCKVQTKQYKALKNHQLEV----------SPKCEHKTILKSLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRQQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKHLFERQEREIETFDMESLRMGFGN 853
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: cirbp (cold inducible RNA binding protein [Source:Xenbase;Acc:XB-GENE-492781]) HSP 1 Score: 347.051 bits (889), Expect = 1.342e-102 Identity = 164/319 (51.41%), Postives = 220/319 (68.97%), Query Frame = 2
Query: 140 LRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+R + K+ PDI+ LF +DP I+ DL +IG G+FGAVY+A N +T E+VAIK++ GK+ E W+DI +EV+FL++L H N + YKGCYLKD AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y K+D+WSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ F F+ LQK P +RP++ + L+ F R VL +I RTK+AV + K++K+L+
Sbjct: 10 MRRGLLKD-PDIADLFCKEDPERIFVDLHEIGHGSFGAVYFATNSTTNEVVAIKKMSYSGKQMN---EKWQDIVKEVKFLQQLQHPNTIEYKGCYLKDHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASKSSPANSFVGTPYWMAPEVILAMDEGQYEGKIDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWTDSFKGFVDYCLQKIPQERPTSLELLRHDFVRRERPPRVLIDLIQRTKDAVRELDNLQYRKMKKILF 322 HSP 2 Score: 127.102 bits (318), Expect = 4.679e-29 Identity = 79/251 (31.47%), Postives = 139/251 (55.38%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q + L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK+ E +I+KQ++D +Q KQ+K L+ +L + K +L++L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + LF+RQ E+++FD + R+G N
Sbjct: 653 HAMLIRHDESTRELEYRQLQMLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKVMEMQIKKQFQDTCKVQTKQYKALKNHQLEV----------SPKCEHKTILKSLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRQQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKHLFERQEREIETFDMESLRMGFGN 893
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: cirbp (cold inducible RNA binding protein [Source:Xenbase;Acc:XB-GENE-492781]) HSP 1 Score: 346.665 bits (888), Expect = 2.411e-102 Identity = 164/319 (51.41%), Postives = 220/319 (68.97%), Query Frame = 2
Query: 140 LRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+R + K+ PDI+ LF +DP I+ DL +IG G+FGAVY+A N +T E+VAIK++ GK+ E W+DI +EV+FL++L H N + YKGCYLKD AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y K+D+WSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ F F+ LQK P +RP++ + L+ F R VL +I RTK+AV + K++K+L+
Sbjct: 16 MRRGLLKD-PDIADLFCKEDPERIFVDLHEIGHGSFGAVYFATNSTTNEVVAIKKMSYSGKQMN---EKWQDIVKEVKFLQQLQHPNTIEYKGCYLKDHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASKSSPANSFVGTPYWMAPEVILAMDEGQYEGKIDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWTDSFKGFVDYCLQKIPQERPTSLELLRHDFVRRERPPRVLIDLIQRTKDAVRELDNLQYRKMKKILF 328 HSP 2 Score: 127.102 bits (318), Expect = 4.810e-29 Identity = 79/251 (31.47%), Postives = 139/251 (55.38%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q + L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK+ E +I+KQ++D +Q KQ+K L+ +L + K +L++L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + LF+RQ E+++FD + R+G N
Sbjct: 659 HAMLIRHDESTRELEYRQLQMLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKVMEMQIKKQFQDTCKVQTKQYKALKNHQLEV----------SPKCEHKTILKSLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRQQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKHLFERQEREIETFDMESLRMGFGN 899
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Taok3 (TAO kinase 3 [Source:MGI Symbol;Acc:MGI:3041177]) HSP 1 Score: 335.495 bits (859), Expect = 3.730e-102 Identity = 161/310 (51.94%), Postives = 214/310 (69.03%), Query Frame = 2
Query: 167 PDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
P+I+ LF DDP ++ DL +IG G+FGAVY+A N T E+VA+K++ GK+ E W+DI +EV+FL++L H N + YKGCYLK+ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L W+ F F+ L K P +RP+A + L+ F R VL +I RTK+AV + K++K+L+
Sbjct: 9 PEIADLFFKDDPEELFIDLHEIGHGSFGAVYFATNAHTNEVVAVKKMSYSGKQT---HEKWQDILKEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHFHSLIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQS-REWTDSFRRFVDYCLHKIPQERPAAVELLRHDFIRRERPPKVLIDLIQRTKDAVRELDNLQYRKMKKILF 313
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Taok1 (TAO kinase 1 [Source:MGI Symbol;Acc:MGI:1914490]) HSP 1 Score: 346.28 bits (887), Expect = 1.176e-101 Identity = 166/323 (51.39%), Postives = 224/323 (69.35%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R K+ P+I+ LF +DP ++TDLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L WS +F +F+ S LQK P RP++ + L+ F VL +I RTK+AV + K++K+L+
Sbjct: 1 MPSTNRAGSLKD-PEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQST---EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLF 317 HSP 2 Score: 157.532 bits (397), Expect = 1.672e-38 Identity = 160/550 (29.09%), Postives = 273/550 (49.64%), Query Frame = 2
Query: 1574 SQNKSTGDVSESKTSMISPSRIMPGQISQQPLIENMISHLDISDPSVLYPPPGAGT--------SNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEI-----------KSAKKNAKSESGSN-----------------NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASS 3091
S +KS D+ E +++S S ++ + ++ E SDP PP +FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+KQL LE + E + + L++D + R N E+EKL HQ +EK K + N E + + +A K E+ K K+ K E N NIQ L+ R++ +E R+ KR LL NLE+ E++ ++ Q + E+A++L QHE +Q LE++ + +++ + I+ QH E+ NQL+Y + E +++++H EV+ PK LK KE +I+KQ++D IQ +Q+K LR L + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N V+S S +A S
Sbjct: 375 SDDKSELDMMEGDHTVMSNSSVIHLKPEEENYQEEGDPRTRASDPQ---SPPQVSRHKSHYRNREHFATIRTASLV------TRQMQEH---EQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKS----------EHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNM-VLSNLSPEAFS 901
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Taok1 (TAO kinase 1 [Source:MGI Symbol;Acc:MGI:1914490]) HSP 1 Score: 346.28 bits (887), Expect = 1.176e-101 Identity = 166/323 (51.39%), Postives = 224/323 (69.35%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R K+ P+I+ LF +DP ++TDLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L WS +F +F+ S LQK P RP++ + L+ F VL +I RTK+AV + K++K+L+
Sbjct: 1 MPSTNRAGSLKD-PEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQST---EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLF 317 HSP 2 Score: 157.532 bits (397), Expect = 1.672e-38 Identity = 160/550 (29.09%), Postives = 273/550 (49.64%), Query Frame = 2
Query: 1574 SQNKSTGDVSESKTSMISPSRIMPGQISQQPLIENMISHLDISDPSVLYPPPGAGT--------SNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEI-----------KSAKKNAKSESGSN-----------------NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASS 3091
S +KS D+ E +++S S ++ + ++ E SDP PP +FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+KQL LE + E + + L++D + R N E+EKL HQ +EK K + N E + + +A K E+ K K+ K E N NIQ L+ R++ +E R+ KR LL NLE+ E++ ++ Q + E+A++L QHE +Q LE++ + +++ + I+ QH E+ NQL+Y + E +++++H EV+ PK LK KE +I+KQ++D IQ +Q+K LR L + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N V+S S +A S
Sbjct: 375 SDDKSELDMMEGDHTVMSNSSVIHLKPEEENYQEEGDPRTRASDPQ---SPPQVSRHKSHYRNREHFATIRTASLV------TRQMQEH---EQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKS----------EHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNM-VLSNLSPEAFS 901
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Taok3 (TAO kinase 3 [Source:MGI Symbol;Acc:MGI:3041177]) HSP 1 Score: 343.584 bits (880), Expect = 1.545e-101 Identity = 161/310 (51.94%), Postives = 214/310 (69.03%), Query Frame = 2
Query: 167 PDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
P+I+ LF DDP ++ DL +IG G+FGAVY+A N T E+VA+K++ GK+ E W+DI +EV+FL++L H N + YKGCYLK+ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L W+ F F+ L K P +RP+A + L+ F R VL +I RTK+AV + K++K+L+
Sbjct: 9 PEIADLFFKDDPEELFIDLHEIGHGSFGAVYFATNAHTNEVVAVKKMSYSGKQT---HEKWQDILKEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHFHSLIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSR-EWTDSFRRFVDYCLHKIPQERPAAVELLRHDFIRRERPPKVLIDLIQRTKDAVRELDNLQYRKMKKILF 313 HSP 2 Score: 124.79 bits (312), Expect = 2.302e-28 Identity = 81/251 (32.27%), Postives = 136/251 (54.18%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK E +I+KQ++D +Q KQ+K L+ +L N H K +L+ L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + TL +RQ E ++FD + R+G N
Sbjct: 646 HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPK------NEH----KAILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKTLLERQERETETFDMESLRMGFGN 886
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Taok3 (TAO kinase 3 [Source:MGI Symbol;Acc:MGI:3041177]) HSP 1 Score: 343.584 bits (880), Expect = 1.545e-101 Identity = 161/310 (51.94%), Postives = 214/310 (69.03%), Query Frame = 2
Query: 167 PDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
P+I+ LF DDP ++ DL +IG G+FGAVY+A N T E+VA+K++ GK+ E W+DI +EV+FL++L H N + YKGCYLK+ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L W+ F F+ L K P +RP+A + L+ F R VL +I RTK+AV + K++K+L+
Sbjct: 9 PEIADLFFKDDPEELFIDLHEIGHGSFGAVYFATNAHTNEVVAVKKMSYSGKQT---HEKWQDILKEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHFHSLIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSR-EWTDSFRRFVDYCLHKIPQERPAAVELLRHDFIRRERPPKVLIDLIQRTKDAVRELDNLQYRKMKKILF 313 HSP 2 Score: 124.79 bits (312), Expect = 2.302e-28 Identity = 81/251 (32.27%), Postives = 136/251 (54.18%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK E +I+KQ++D +Q KQ+K L+ +L N H K +L+ L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + TL +RQ E ++FD + R+G N
Sbjct: 646 HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPK------NEH----KAILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKTLLERQERETETFDMESLRMGFGN 886
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q9I9E0|TAOK3_CHICK (Serine/threonine-protein kinase TAO3 OS=Gallus gallus OX=9031 GN=TAOK3 PE=2 SV=2) HSP 1 Score: 349.747 bits (896), Expect = 5.877e-103 Identity = 165/310 (53.23%), Postives = 216/310 (69.68%), Query Frame = 2
Query: 167 PDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
P+I+ LF DDP I+ L +IG G+FGAVY+A N T E+VA+K++ GK+ E W+DI +EV+FL++L H N + YKGCYLK+ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S +SPANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA NDSP L WS F F+ LQK P +RPS+ D L+ F R + VL +I RTK+AV + K++K+L+
Sbjct: 9 PEIADLFYKDDPEEIFVGLHEIGHGSFGAVYFATNSHTNEVVAVKKMSYSGKQTN---EKWQDIIKEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDMLEVHKKPLQEVEIAAITHGALQGLAYLHSHCKIHRDIKAGNILLTEPGQVKLADFGSASIVSPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSN-EWSDSFRGFVDYCLQKIPQERPSSADLLRHDFVRRDRPPRVLIDLIQRTKDAVRELDNLQYRKMKKILF 313 HSP 2 Score: 120.553 bits (301), Expect = 3.094e-26 Identity = 78/251 (31.08%), Postives = 135/251 (53.78%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK E +I+KQ++D +Q KQ+K L+ +L + K +L++L+DE+ RK A L QYE SI+ + Q + D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + L +RQ E+++FD + R+G N
Sbjct: 646 HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHFMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKS----------EHKTILKSLKDEQTRKLAILAEQYEQSINEMMASQALRRDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKFLLERQEREIETFDMESLRMGFGN 886
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q0KHQ5|TAO_DROME (Serine/threonine-protein kinase Tao OS=Drosophila melanogaster OX=7227 GN=Tao PE=1 SV=1) HSP 1 Score: 352.829 bits (904), Expect = 8.388e-103 Identity = 175/323 (54.18%), Postives = 226/323 (69.97%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLN-WSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKML 1093
MP RP K+ P+I+ LF DP I+ DLR+IG G+FGAVYYAR T+EIVAIK++ GK+ +E W+DI +E+RFLR+L+H N + YKGCYL++ AWLVM+YC+GS +DI+EVHK+ L E EIA + VL GL YLH G IHRDIKA NIL+TD G +K+ DFGS + PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PPYF +N M+A+Y IA N+SP L P N WS F SF+ L+K P +RPS+ L + S VL ++IARTK+AV + K++K+L
Sbjct: 1 MPSA-RPGSLKD-PEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQS---QEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYF-NMNAMSALYHIAQNESPTL--PKNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKIL 315 HSP 2 Score: 136.346 bits (342), Expect = 4.764e-31 Identity = 85/262 (32.44%), Postives = 148/262 (56.49%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQA 3085
+A++L HEK Q LEY+Q++++H+L+ +QI KQHD E+ NQ Y + + ++ ++H+ E++ PK LK KE +IRKQ+R+ Q KQ+K R A V +K++++ L++E+ RK L QYE SI + + Q+ K+D +Q+ E + H+ LE E ML+ +Q ++ Q+ + L++R++ R+ LLE + + +F R L ++ EL++FDN + LG ++ SR+A
Sbjct: 760 HAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKTQTKQYK----------RYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFSTLSLIE-VSREA 1010
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q9H2K8|TAOK3_HUMAN (Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2) HSP 1 Score: 347.051 bits (889), Expect = 6.336e-102 Identity = 164/319 (51.41%), Postives = 220/319 (68.97%), Query Frame = 2
Query: 140 LRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+R + K+ P+I+ LF DDP ++ L +IG G+FGAVY+A N T E+VAIK++ GK+ E W+DI +EV+FLR+L H N + YKGCYLK+ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L W+ F F+ LQK P +RP++ + L+ F R + VL +I RTK+AV + K++K+L+
Sbjct: 1 MRKGVLKD-PEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQT---HEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSN-EWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILF 313 HSP 2 Score: 124.02 bits (310), Expect = 2.628e-27 Identity = 80/251 (31.87%), Postives = 136/251 (54.18%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK E +I+KQ++D +Q KQ+K L+ +L N H K +L+ L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + L +RQ E+++FD + R+G N
Sbjct: 646 HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPK------NEH----KTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGN 886
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q53UA7|TAOK3_RAT (Serine/threonine-protein kinase TAO3 OS=Rattus norvegicus OX=10116 GN=Taok3 PE=1 SV=1) HSP 1 Score: 344.354 bits (882), Expect = 6.945e-101 Identity = 164/319 (51.41%), Postives = 219/319 (68.65%), Query Frame = 2
Query: 140 LRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
+R + K+ P+I+ LF +DP ++ DL +IG G+FGAVY+A N T E+VAIK++ GK+ E W+DI +EVRFL++L H N + YKGCYLK+ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L W+ F F+ L K P +RP+A + L+ F R VL +I RTK+AV + K++K+L+
Sbjct: 1 MRKGVLKD-PEIAELFFKEDPEELFIDLHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQT---HEKWQDILKEVRFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHFHSLIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSR-EWTDSFRRFVDYCLHKIPQERPAAAELLRHDFIRRERPPRVLIDLIQRTKDAVRELDNLQYRKMKKILF 313 HSP 2 Score: 123.25 bits (308), Expect = 4.674e-27 Identity = 80/251 (31.87%), Postives = 136/251 (54.18%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A+++ E + LEY+Q L +L+MD I+ QH E+ENQL+Y + E ++ ++H E++ PK LK E +I+KQ++D +Q KQ+K L+ +L N H K +L+ L++E+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+A LE I+++ Q R + TL +RQ E ++FD + R+G N
Sbjct: 646 HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPK------NEH----KAILKTLKEEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKTLLERQERETETFDMESLRMGFGN 886
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|O88664|TAOK1_RAT (Serine/threonine-protein kinase TAO1 OS=Rattus norvegicus OX=10116 GN=Taok1 PE=1 SV=1) HSP 1 Score: 346.665 bits (888), Expect = 7.082e-101 Identity = 166/323 (51.39%), Postives = 224/323 (69.35%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R K+ P+I+ LF +DP ++TDLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L WS +F +F+ S LQK P RP++ + L+ F VL +I RTK+AV + K++K+L+
Sbjct: 1 MPSTNRAGSLKD-PEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQST---EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSN-EWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLF 317 HSP 2 Score: 157.918 bits (398), Expect = 8.278e-38 Identity = 147/485 (30.31%), Postives = 250/485 (51.55%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEI-----------KSAKKNAKSESGSN-----------------NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASS 3091
+FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+KQL LE + E + + L++D + R N E+EKL HQ +EK K + N E + + +A K E+ K K+ K E N NIQ L+ R++ +E R+ KR LL NLE+ E++ ++ Q + E+A++L QHE +Q LE++ + +++ + I+ QH E+ NQL+Y + E +++++H EV+ PK LK KE +I+KQ++D IQ +Q+K LR L + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N V+S S +A S
Sbjct: 437 HFATIRTASLV------TRQMQEH---EQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQASMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKS----------EHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNM-VLSNLSPEAFS 901
BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A4S2LQC1 (Protein kinase domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_005599 PE=4 SV=1) HSP 1 Score: 438.728 bits (1127), Expect = 9.023e-131 Identity = 214/325 (65.85%), Postives = 261/325 (80.31%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSR--DVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP+ LR S+FK+ P++S LF+++DPT I+TDLRQIGCG+FGAVYYARN T E+VAIKE+KVD K+KKS+ E+W DI RE+RFL L H NC+ KGCY+KDQ WLVM+YC+GSVADILEVHK LRE+EIAC+V EVL GLQYLH + IHRDIKA+NIL+TD GG+KIGDFGS SF+SPANSFVGTPFWIAPEVILAME G+Y+ +VD+WSLGITCIEMAE+EPPYF NPMAA+YQIASND+P+LT +WS F F++ +LQK RP AL PF +V+R + L ++I RTK AVAAQE Q+S K +K+LY
Sbjct: 1 MPRSLRNSVFKD-PELSRLFSHEDPTHIFTDLRQIGCGSFGAVYYARNRLTDEVVAIKELKVDTKRKKSD-EEWNDIVREIRFLSGLSHNNCVLPKGCYMKDQIPWLVMEYCIGSVADILEVHKLPLRENEIACIVREVLFGLQYLHSSHRIHRDIKAANILLTDSGGVKIGDFGSASFLSPANSFVGTPFWIAPEVILAMEDGIYDCRVDIWSLGITCIEMAELEPPYFSATNPMAALYQIASNDAPRLTGG-DWSDVFRDFVSFVLQKDVATRPFCDQALAHPFC-IDVTRLIETLAELIQRTKAAVAAQENQISQKWKKILY 321 HSP 2 Score: 270.396 bits (690), Expect = 5.621e-71 Identity = 190/554 (34.30%), Postives = 297/554 (53.61%), Query Frame = 2
Query: 1721 PPPGAGTSNFATLKTSRMMKGS----------------HAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEIKSAKKN-----AKSESGSNNIQELIDR-------RQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMR------------NAADVNINN-------------HAI---------NEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASSSVRSQMPXXXXXXXXXXXXXXMPDWRHSRADFMPS 3196
PPP G F+TLKTS+MM+GS A + + WR+QMN LKRLR+QH KQ+KQL ++N EEE LK LNR+++ + KE ++LE H +LE+ +K T E + E++TK ++KSAKK + +S + + +D RQ LTN+ELR+ KRE+L+ +Q LE + + ++L++K ++ AL+L QH KL+ LE + +H L++ Q++KQH E+ N QY + +++++ +H E KNLPK LK +E +I KQ++DAA IQKKQFK+LREER++A R ++D +NN H + +E+Q+LENL+ EE+RKQ+DL QY+ ++ L+++QNDK+DST+I+E+ + + +L +Q Q +++ ++ LK+RI RK LE +++ D + L ++ A L++FD T LGIDN V+ + R DWRHSR +F+PS
Sbjct: 605 PPPTTGY--FSTLKTSQMMRGSMFNWNRSANPSDAISSGAVMLGLPHVIEGRASGFWRDQMNELKRLRTQHNKQMKQLVDKNKSEEEQLKYRLNREYETAKAVMKKEFQRLEEAHAAELERERKRATTAEADLANRLESETKAQLKSAKKARTRPVSTHDSPTTGTLKKVDSVDAIRRLRQDLTNLELRRAKRETLVLMQKLEGEHLHQYVRLEQKAGDQITALLLDQHAKLEELELGHLKKVHDLRLAQLEKQHQAELNNHHQYMERAKSKLQAKHLLEKKNLPKSLKQREIQIFKQFQDAARIQKKQFKLLREERIKAFRRTMELGTGPVSLGSSDSGVNNASGSSPASDRQDGHEVPLSVFPVFQDERQILENLKQEEKRKQSDLHEQYKKTVTELQKRQNDKVDSTRIREMEELEKHRAEGTKVLQHYQESQLRDVKKQQQKEREDLKNRIQSRKDSLEAAVKKNTDSLKEEAARKTRRLMEQHAQNLRAFDAQTASLGIDNAAVIGISDRMFGGGGPPGSGSGSSFGAGQRPA----DWRHSRMEFLPS 1152
BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A1S8X1V7 (Kinase domain protein OS=Opisthorchis viverrini OX=6198 GN=X801_03459 PE=4 SV=1) HSP 1 Score: 435.647 bits (1119), Expect = 7.775e-130 Identity = 214/325 (65.85%), Postives = 259/325 (79.69%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSR--DVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP+ LR S+FK+ P++S LF+++DPT I+TDLRQIGCG+FGAVYYARN T E+VAIKE+KVD K+KKS+ E+W DI RE+RFL L H NC+ KGCY+KDQ WLVM+YC+GSVADILEVHK LRE+EIAC+V EVL GLQYLH + IHRDIKA+NIL+TD GG+KIGDFGS SF+SPANSFVGTPFWIAPEVILAME G+Y+ +VD+WSLGITCIEMAE+EPPYF NPMAA+YQIASND+P+LT +WS F F++ +LQK RP AL F NVS + L ++I RTK AVAAQE Q+S K +K+LY
Sbjct: 1 MPRSLRNSVFKD-PELSRLFSHEDPTHIFTDLRQIGCGSFGAVYYARNRLTDEVVAIKELKVDTKRKKSD-EEWNDIVREIRFLSGLSHNNCVLPKGCYMKDQIPWLVMEYCIGSVADILEVHKLPLRENEIACIVREVLFGLQYLHSSHRIHRDIKAANILLTDSGGVKIGDFGSASFLSPANSFVGTPFWIAPEVILAMEDGIYDCRVDIWSLGITCIEMAELEPPYFSATNPMAALYQIASNDAPRLTGG-DWSDVFRDFVSFVLQKDVATRPFCDQALAHSFC-INVSHLIETLAELIQRTKAAVAAQENQISQKWKKILY 321 HSP 2 Score: 270.396 bits (690), Expect = 4.477e-71 Identity = 190/555 (34.23%), Postives = 300/555 (54.05%), Query Frame = 2
Query: 1718 YPPPGAGTSNFATLKTSRMMKGS----------------HAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEIKSAKK--------NAKSESGS----NNIQELIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMR------------NAADVNINN-------------HAI---------NEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASSSVRSQMPXXXXXXXXXXXXXXMPDWRHSRADFMPS 3196
+PP T +F+TLKTS+MM+GS A + + WR+QMN LKRLR+QH KQ+KQL ++N EEE LK LNR+++ + KE ++LE H +LE+ +K T E + E++TK ++KSAKK + SG+ +++ + RQ LTN+ELR+ KRE+L+ +Q LE + + ++L++K ++ AL+L QH KL+ LE + +H L++ Q++KQH E+ N QY + +++++ +H E KNLPK LK +E +I KQ++DAA IQKKQFK+LREER++A R ++D +NN H + +E+Q+LENL+ EE+RKQ+DL QY+ ++ L+++QNDK+DST+I+E+ + + +L +Q Q +++ ++ LK+RI RK LE +++ D + L ++ A L++FD T LGIDN VV ++R DWRHSR +F+PS
Sbjct: 587 FPP--LATGHFSTLKTSQMMRGSMFNWNRSANPSDAISTGAVMLGLPHVIEGRASGFWRDQMNELKRLRTQHNKQMKQLVDKNKSEEEQLKYRLNREYETAKAVMKKEFQRLEEAHAAELERERKRATTAEADLANRLESETKAQLKSAKKARTRPVSTHDSPTSGTLKKVDSVDAIRRLRQDLTNLELRRAKRETLVLMQKLEGEHLHQYVRLEQKAGDQITALLLDQHAKLEELELGHLKKVHDLRLAQLEKQHQAELNNHHQYMERAKSKLQAKHLLEKKNLPKSLKQREIQIFKQFQDAARIQKKQFKLLREERIKAFRRTMELGTGPVSLGSSDSGVNNASGSSPASDRQDGHEVPLSVFPVFQDERQILENLKQEEKRKQSDLHEQYKKTVTELQKRQNDKVDSTRIREMEELEKHRAEGTKVLQHYQESQLRDVKKQQQKEREDLKNRIQSRKDSLEAAVKKNTDSLKEEAARKTRRLMEQHAQNLRAFDAQTASLGIDNAAVVGISARMFGGGGPPGSGSGSSFGAGQRPA----DWRHSRMEFLPS 1135
BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A074Z4U7 (Protein kinase domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_09724 PE=4 SV=1) HSP 1 Score: 435.261 bits (1118), Expect = 1.410e-129 Identity = 214/325 (65.85%), Postives = 259/325 (79.69%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSR--DVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP+ LR S+FK+ P++S LF+++DPT I+TDLRQIGCG+FGAVYYARN T E+VAIKE+KVD K+KKS+ E+W DI RE+RFL L H NC+ KGCY+KDQ WLVM+YC+GSVADILEVHK LRE+EIAC+V EVL GLQYLH + IHRDIKA+NIL+TD GG+KIGDFGS SF+SPANSFVGTPFWIAPEVILAME G+Y+ +VD+WSLGITCIEMAE+EPPYF NPMAA+YQIASND+P+LT +WS F F++ +LQK RP AL F NVS + L ++I RTK AVAAQE Q+S K +K+LY
Sbjct: 1 MPRSLRNSVFKD-PELSRLFSHEDPTHIFTDLRQIGCGSFGAVYYARNRLTDEVVAIKELKVDTKRKKSD-EEWNDIVREIRFLSGLSHNNCVLPKGCYMKDQIPWLVMEYCIGSVADILEVHKLPLRENEIACIVREVLFGLQYLHSSHRIHRDIKAANILLTDSGGVKIGDFGSASFLSPANSFVGTPFWIAPEVILAMEDGIYDCRVDIWSLGITCIEMAELEPPYFSATNPMAALYQIASNDAPRLTGG-DWSDVFRDFVSFVLQKDVATRPFCDQALAHSFC-INVSHLIETLAELIQRTKAAVAAQENQISQKWKKILY 321 HSP 2 Score: 270.396 bits (690), Expect = 5.561e-71 Identity = 190/555 (34.23%), Postives = 300/555 (54.05%), Query Frame = 2
Query: 1718 YPPPGAGTSNFATLKTSRMMKGS----------------HAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEIKSAKK--------NAKSESGS----NNIQELIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMR------------NAADVNINN-------------HAI---------NEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASSSVRSQMPXXXXXXXXXXXXXXMPDWRHSRADFMPS 3196
+PP G +F+TLKTS+MM+GS A + + WR+QMN LKRLR+QH KQ+KQL ++N EEE LK LNR+++ + KE ++LE H +LE+ +K T E + E++TK ++KSAKK + SG+ +++ + RQ LTN+ELR+ KRE+L+ +Q LE + + ++L++K ++ AL+L QH KL+ LE + +H L++ Q++KQH E+ N QY + +++++ +H E KNLPK LK +E +I KQ++DAA IQKKQFK+LREER++A R ++D +NN H + +E+Q+LENL+ EE+RKQ+DL QY+ ++ L+++QNDK+DST+I+E+ + + +L +Q Q +++ ++ LK+RI RK LE +++ D + L ++ A L++FD T LGIDN VV ++R DWRHSR +F+PS
Sbjct: 605 FPPLATG--HFSTLKTSQMMRGSMFNWNRSANPSDAISTGAVMLGLPHVIEGRASGFWRDQMNELKRLRTQHNKQMKQLVDKNKSEEEQLKYRLNREYETAKAVMKKEFQRLEEAHAAELERERKRATTAEADLANRLESETKAQLKSAKKARTRPVSTHDSPTSGTLKKVDSVDAIRRLRQDLTNLELRRAKRETLVLMQKLEGEHLHQYVRLEQKAGDQITALLLDQHAKLEELELGHLKKVHDLRLAQLEKQHQAELNNHHQYMERAKSKLQAKHLLEKKNLPKSLKQREIQIFKQFQDAARIQKKQFKLLREERIKAFRRTMELGTGPVSLGSSDSGVNNASGSSPASDRQDGHEVPLSVFPVFQDERQILENLKQEEKRKQSDLHEQYKKTVTELQKRQNDKVDSTRIREMEELEKHRAEGTKVLQHYQESQLRDVKKQQQKEREDLKNRIQSRKDSLEAAVKKNTDSLKEEAARKTRRLMEQHAQNLRAFDAQTASLGIDNAAVVGISARMFGGGGPPGSGSGSSFGAGQRPA----DWRHSRMEFLPS 1153
BLAST of Serine/threonine kinase vs. TrEMBL
Match: G4V6P6 (Serine/threonine kinase OS=Schistosoma mansoni OX=6183 GN=Smp_068060.1 PE=4 SV=1) HSP 1 Score: 431.409 bits (1108), Expect = 1.861e-129 Identity = 206/325 (63.38%), Postives = 258/325 (79.38%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSR--DVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MPK LR ++FK+ P++S F++++PT ++TD RQIGCG+FGAVYYARN +T E+VAIKE+KVD K+KKSE E+W DI RE++FL L HKNC+ KGC++K+Q WLVM+YC+GSVAD+LEVHK+ LRE EIAC+V EVL GL YLH IHRDIKA+NIL+TD GG+KIGDFGS SF+SPANSFVGTPFWIAPEVILAME G+Y+ +VDVWSLGITCIEMAE+EPPYF NPMAA+YQIASND+P+L +WS F F+ +LQK ++RP A+ PF +V R +L ++I RTK AVAAQE Q+S K +K+LY
Sbjct: 1 MPKSLRTTVFKD-PELSKYFSHENPTTVFTDFRQIGCGSFGAVYYARNRTTGEVVAIKELKVDTKRKKSE-EEWNDIVREIKFLSHLSHKNCVLPKGCFMKEQTPWLVMEYCIGSVADVLEVHKKPLREDEIACIVQEVLTGLDYLHSEKRIHRDIKAANILLTDSGGVKIGDFGSASFVSPANSFVGTPFWIAPEVILAMEQGIYDVRVDVWSLGITCIEMAELEPPYFSATNPMAALYQIASNDAPRLVGG-SWSDEFRDFVRFVLQKDMNERPFCSQAMTHPF-LASVFRFSHILPELIQRTKAAVAAQENQISQKWKKILY 321 HSP 2 Score: 238.424 bits (607), Expect = 5.759e-61 Identity = 161/407 (39.56%), Postives = 245/407 (60.20%), Query Frame = 2
Query: 1682 ISHLDISDPSVLYPPPGAGTSNFATLKTSRMMKG----------SHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEIKSAKKN---------AKSESGSNNIQELIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVN---------------------------------INNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQN 2746
++ ++I+ P+ + G +FATLKT++MM+G + A + F ++ + A+WR+QMN LKRLR+QH K LKQ+E++N VEEE+LK LNRD++ T+ KE +LE +H ++EK +K ++E++ R+ E +TK E+KSAKK+ + S SN ++ + RR ++ +E RK KR L ++Q++E +Q + I+LQ+K E +L+L QH +L+ LE Q + + L+++Q++ QH+ EMEN QY + E ++KRH E KNLPKYLK KE +IRKQ+RDAA IQKKQFK+LREERL+A R +++ + H +E+Q+LENL+ EE+RKQADLE+QY SI L +QN
Sbjct: 603 LASVEINSPADISSSAG----HFATLKTTQMMRGLSLEPGASNSAAAVALGFTQQGYGRGMANWRDQMNELKRLRNQHNKHLKQVEDKNKVEEESLKSRLNRDYEATKLAMRKEFMRLEEIHAAEVEKERKRAMSVESKLARQLETETKSELKSAKKSPFGSFSSHESDSSGHSNPLEAIRKRRHDVSTLETRKTKRLLLTQLQDIEMEQLRQYIRLQQKAAEEITSLLLRQHTELENLEINQLKRIQDLRINQLQSQHEAEMENLHQYFKRIEVGLQKRHCEETKNLPKYLKQKELQIRKQFRDAARIQKKQFKLLREERLKAARRTSELGSSPFSGASESCTSSGLMSSNSNNCSDSVDLQGQLVIHLQDERQILENLKLEEKRKQADLEAQYNKSISELHERQN 1005
BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A4Z2CTN8 (Serine/threonine-protein kinase Tao OS=Schistosoma japonicum OX=6182 GN=EWB00_007704 PE=4 SV=1) HSP 1 Score: 434.106 bits (1115), Expect = 1.885e-129 Identity = 207/325 (63.69%), Postives = 257/325 (79.08%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSR--DVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MPK LR ++FK+ P++S F ++DPT ++TD RQIGCG+FGAVYYAR+ +T E+VAIKE+KVD K+KKSE E+W DI RE++FL L H+NC+ KGC++KDQ WLVM+YC+GSVAD+LEVHK+ LRE EIAC+V EVL GL YLH IHRDIKA+NIL+TD GG+KIGDFGS SF+SPANSFVGTPFWIAPEVILAME G+Y+ +VDVWSLGITCIEMAE+EPPYF NPMAA+YQIASND+P+L NWS F F+ +LQK ++RP A+ PF +V R +L ++I RTK AVAAQE Q+S K +K+LY
Sbjct: 1 MPKSLRTTVFKD-PELSKYFNHEDPTTVFTDFRQIGCGSFGAVYYARSRTTSEVVAIKELKVDTKRKKSE-EEWNDIVREIKFLSHLSHRNCVLPKGCFMKDQTPWLVMEYCIGSVADVLEVHKKPLREDEIACIVQEVLTGLDYLHSEKRIHRDIKAANILLTDSGGVKIGDFGSASFVSPANSFVGTPFWIAPEVILAMEQGIYDVRVDVWSLGITCIEMAELEPPYFSATNPMAALYQIASNDAPRLVGG-NWSDEFRDFVRFVLQKDMNERPFCSQAMTHPF-LASVFRFSHILPELIQRTKAAVAAQENQISQKWKKILY 321 HSP 2 Score: 266.544 bits (680), Expect = 6.227e-70 Identity = 177/452 (39.16%), Postives = 269/452 (59.51%), Query Frame = 2
Query: 1724 PPGAGTSNFATLKTSRMMKG----------SHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEIKSAKKNAK---------SESGSNNIQELIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVN-----------------------------INNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQ 2935
P + +FATLKTS+MM+G + A + F ++ + A+WR+QMN LKRLR+QH K LKQ+E++N VEEE+LK LNRD++ T+ KE +LE +H ++EK +K ++E++ R+ E +TK E+KSAKK++ S SN ++ + RRQ ++ +E RK KR L ++Q++E +Q + I+LQ+K + +L+L QH +L+ LE Q + + L+++Q++ QH+ EMEN QY + E ++KRH E KNLPKYLK KE +IRKQ+RDAA IQKKQFK+LREERL+A R +++ + H +E+Q+LENL+ EE+RKQADLE+QY SI L +QN K++S+ +E + + + +LS FQ Q+ M + H L++RI RK LE ++
Sbjct: 613 PDTSSVGHFATLKTSQMMRGLSLEPDASNSAAAVALGFTQQGYGRGMANWRDQMNELKRLRNQHNKHLKQVEDKNKVEEESLKSRLNRDYEATKLTMRKEFMRLEEIHAAEIEKERKRAMSVESKLARQLETETKSELKSAKKSSFGSFSSQDSNSAGHSNPLEAIRKRRQDVSTLETRKTKRLLLTQLQDIEMEQLRQYIRLQQKAADEITSLLLRQHTELENLEINQLKRIQDLRINQLQSQHEAEMENLHQYFKRIEVGLQKRHCEETKNLPKYLKQKELQIRKQFRDAARIQKKQFKLLREERLKAARRTSELGSPFSGASESCVSSGLMSSNSNNCSDSVDQLVIHLQDERQILENLKLEEKRKQADLEAQYSKSISELHERQNGKVESSHARENKEFKESRLEGVKILSNFQEKQRRDMLKQHQRQREDLENRIRARKESLEAAVR 1064
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: taok1a (serine/threonine-protein kinase TAO1-like [Source:NCBI gene;Acc:103025376]) HSP 1 Score: 354.369 bits (908), Expect = 1.834e-104 Identity = 166/323 (51.39%), Postives = 227/323 (70.28%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP +R K+ PDI+ LF +DP ++ DLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ +F +F+ S LQK P RP+ + LQ F + VL+++I RTK+AV + S K++K+L+
Sbjct: 1 MPNAVRAGSLKD-PDIADLFFKEDPEKLFIDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYSGKQTN---EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDVLEVHKKPLQELEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGLVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSS-EWTDYFRNFVDSCLQKLPQDRPTCEELLQHAFVLRERAESVLNELIQRTKDAVRELDNLQSRKMKKILF 317 HSP 2 Score: 147.902 bits (372), Expect = 1.356e-35 Identity = 145/491 (29.53%), Postives = 254/491 (51.73%), Query Frame = 2
Query: 1721 PPPGAGT--------SNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLE------TQTLRKWEADT-----KGEIKSAKKNAKSESGSN-----------------NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQ---RLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
P P A T +FATL+T+ ++ + QE ++ ++ REQM+G KR+R QH+KQL LE + E + + L+++ ++ R + + E++KL HQ +EK K N E Q+ +K E + K E K K+ K E N NIQ L+ R++ ++E R+ KR L+ N+E+ E++ ++ Q + E+A++L HE +Q LE++ + +++ + I+ QH E+ NQ++Y + E +++++H EV+ PK LK KE +I+KQ+++ IQ +Q+KILR + L N + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q E L++E +L+ +Q ++Q E Q + L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N
Sbjct: 422 PSPPAQTPRRQYRNREHFATLRTASLV------TRQIQEH---EQDSELREQMSGYKRMRRQHQKQLLALENKLKSEMDEHRLKLDKELESQRSSFSSEMDKLIKKHQAAMEKDAKTFANDEKKFQQHIQSQQKKELSSFLESQKREYKMRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLDLECRRFKRRILIARHNVEQDLAREELNKRQTQKDLEHAMLLRHHESMQELEFRHLNTIQKMRAELIRLQHQTELNNQMEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQETCKIQTRQYKILRNQLLD----------NTPKSDHKTMLKRLKEEQTRKLAILAEQYDHSINDMLSTQALRLDEAQEAECQVLRMQLQQELELLNAYQSKIKMQTEAQQD---RERKELEQRVSLRRALLEQKIEEEMLALQNERSERIRSLLERQAREIEAFDSESLRLGFSN 890
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: taok1a (serine/threonine-protein kinase TAO1-like [Source:NCBI gene;Acc:103025376]) HSP 1 Score: 353.984 bits (907), Expect = 2.672e-104 Identity = 166/323 (51.39%), Postives = 227/323 (70.28%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP +R K+ PDI+ LF +DP ++ DLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ +F +F+ S LQK P RP+ + LQ F + VL+++I RTK+AV + S K++K+L+
Sbjct: 1 MPNAVRAGSLKD-PDIADLFFKEDPEKLFIDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYSGKQTN---EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDVLEVHKKPLQELEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGLVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSS-EWTDYFRNFVDSCLQKLPQDRPTCEELLQHAFVLRERAESVLNELIQRTKDAVRELDNLQSRKMKKILF 317 HSP 2 Score: 145.591 bits (366), Expect = 8.072e-35 Identity = 134/445 (30.11%), Postives = 235/445 (52.81%), Query Frame = 2
Query: 1835 ADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLE------TQTLRKWEADT-----KGEIKSAKKNAKSESGSN-----------------NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQ---RLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
++ REQM+G KR+R QH+KQL LE + E + + L+++ ++ R + + E++KL HQ +EK K N E Q+ +K E + K E K K+ K E N NIQ L+ R++ ++E R+ KR L+ N+E+ E++ ++ Q + E+A++L HE +Q LE++ + +++ + I+ QH E+ NQ++Y + E +++++H EV+ PK LK KE +I+KQ+++ IQ +Q+KILR + L N + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q E L++E +L+ +Q ++Q E Q + L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N
Sbjct: 461 SELREQMSGYKRMRRQHQKQLLALENKLKSEMDEHRLKLDKELESQRSSFSSEMDKLIKKHQAAMEKDAKTFANDEKKFQQHIQSQQKKELSSFLESQKREYKMRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLDLECRRFKRRILIARHNVEQDLAREELNKRQTQKDLEHAMLLRHHESMQELEFRHLNTIQKMRAELIRLQHQTELNNQMEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQETCKIQTRQYKILRNQLLD----------NTPKSDHKTMLKRLKEEQTRKLAILAEQYDHSINDMLSTQALRLDEAQEAECQVLRMQLQQELELLNAYQSKIKMQTEAQQD---RERKELEQRVSLRRALLEQKIEEEMLALQNERSERIRSLLERQAREIEAFDSESLRLGFSN 892
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: taok1b (TAO kinase 1 [Source:NCBI gene;Acc:103030718]) HSP 1 Score: 348.591 bits (893), Expect = 3.174e-102 Identity = 169/332 (50.90%), Postives = 226/332 (68.07%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY---HCGNGT 1114
MP R K+ P+IS LF +DP +++DLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWL M+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ +F +F+ S LQK P RP + D LQ F + VL +I RTK+AV + K++K+L+ H G T
Sbjct: 1 MPSTNRAGSLKD-PEISELFFKEDPEKLFSDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYSGKQSN---EKWQDIIKEVKFLQRIQHPNSIEYKGCYLREHTAWLAMEYCLGSASDLLEVHKKPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSS-EWTDYFRNFVDSCLQKIPQDRPHSDDLLQHAFVQRERPDTVLIDLILRTKDAVRELDNLQYRKMKKILFQEAHNGPAT 326 HSP 2 Score: 146.362 bits (368), Expect = 4.126e-35 Identity = 141/472 (29.87%), Postives = 248/472 (52.54%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKELTN-LETQT----LRKWEADTK-GEIKSAKKNAKSESGSN---NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+K L LE + E + + L+++ + R + E+EKL HQ +EK +KKEL++ +E+Q LRK + + E +S K K E S N Q L+ R++ +E R+ KR L+ N+E+ E++ ++ Q + E+A++L HE +Q LE +Q +H+++ + I+ QH E+ NQL+Y + E +++++H EV+ PK LK KE +I+KQ++D IQ +Q+K LR L + + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q +E L++E +L+ +Q + H + L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N
Sbjct: 437 HFATIRTASLV------TRQMQEH---EQDSELREQMSGYKRMRRQHQKHLMALENKLKAEMDEHRLRLDKELETQRNSFAAEIEKLVKKHQAAMEKDAKSFANDEKKFQQHIQVQQKKELSSFIESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENFQHFQAEEEANLLRRQRQYLELECRRFKRRILIARHNVEQDLVREELNKRQTQKDLEHAMLLRHHESMQELEVRQLGTIHKMRTELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKS----------DHKAVLKRLKEEQTRKLAILAEQYDHSINDMLSTQALRLDEAQEEECQVLKMQLQQELELLNAYQSKIKMQTDAQHDRERKELEQRVSLRRALLEQKIEEEMLALQNERSERIRSLLERQAREIEAFDSESMRLGFSN 889
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: taok1b (TAO kinase 1 [Source:NCBI gene;Acc:103030718]) HSP 1 Score: 348.206 bits (892), Expect = 4.863e-102 Identity = 169/332 (50.90%), Postives = 226/332 (68.07%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY---HCGNGT 1114
MP R K+ P+IS LF +DP +++DLR+IG G+FGAVY+AR++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWL M+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ +F +F+ S LQK P RP + D LQ F + VL +I RTK+AV + K++K+L+ H G T
Sbjct: 1 MPSTNRAGSLKD-PEISELFFKEDPEKLFSDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYSGKQSN---EKWQDIIKEVKFLQRIQHPNSIEYKGCYLREHTAWLAMEYCLGSASDLLEVHKKPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSS-EWTDYFRNFVDSCLQKIPQDRPHSDDLLQHAFVQRERPDTVLIDLILRTKDAVRELDNLQYRKMKKILFQEAHNGPAT 326 HSP 2 Score: 146.747 bits (369), Expect = 3.726e-35 Identity = 141/472 (29.87%), Postives = 248/472 (52.54%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKELTN-LETQT----LRKWEADTK-GEIKSAKKNAKSESGSN---NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+K L LE + E + + L+++ + R + E+EKL HQ +EK +KKEL++ +E+Q LRK + + E +S K K E S N Q L+ R++ +E R+ KR L+ N+E+ E++ ++ Q + E+A++L HE +Q LE +Q +H+++ + I+ QH E+ NQL+Y + E +++++H EV+ PK LK KE +I+KQ++D IQ +Q+K LR L + + K +L+ L++E+ RK A L QY++SI+ + Q ++D Q +E L++E +L+ +Q + H + L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N
Sbjct: 437 HFATIRTASLV------TRQMQEH---EQDSELREQMSGYKRMRRQHQKHLMALENKLKAEMDEHRLRLDKELETQRNSFAAEIEKLVKKHQAAMEKDAKSFANDEKKFQQHIQVQQKKELSSFIESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENFQHFQAEEEANLLRRQRQYLELECRRFKRRILIARHNVEQDLVREELNKRQTQKDLEHAMLLRHHESMQELEVRQLGTIHKMRTELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKS----------DHKAVLKRLKEEQTRKLAILAEQYDHSINDMLSTQALRLDEAQEEECQVLKMQLQQELELLNAYQSKIKMQTDAQHDRERKELEQRVSLRRALLEQKIEEEMLALQNERSERIRSLLERQAREIEAFDSESMRLGFSN 889
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: taok2a (serine/threonine-protein kinase TAO2-like [Source:NCBI gene;Acc:103028598]) HSP 1 Score: 348.977 bits (894), Expect = 2.000e-101 Identity = 165/323 (51.08%), Postives = 227/323 (70.28%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP +R K+ PD++ LF DDP ++ DLR+IG G+FGAVY+AR++ + E+VAIK++ GK+ E W+DI +EV+FL++L H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRD+KA NIL+T+ G +K+GDFGS S ++PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L +WS +F +F+ S LQK P RP++ L F V+ +IARTK+AV + K++K+L+
Sbjct: 1 MPASVRAGSLKD-PDVADLFYKDDPEKLFADLREIGHGSFGAVYFARDVRSNEVVAIKKMSYSGKQSN---EKWQDIIKEVKFLQKLRHPNTIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGQVKLGDFGSASIVAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPVLASN-HWSDYFRNFVDSCLQKIPQDRPTSDVLLNHRFLCRERPLSVVMDLIARTKDAVRELDNLQYRKMKKILF 317 HSP 2 Score: 152.14 bits (383), Expect = 7.980e-37 Identity = 142/475 (29.89%), Postives = 240/475 (50.53%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKELTNL---ETQTLRKWEADTKGEIKSAKKNAKSESGSNNIQE--------------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSI-DALKRQQNDK--IDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+FAT++T+ ++ + QE ++ + REQM G KR+R QH+KQL LE + E + + L+++ ++ R N E +KL HQ LEK +KKELT L + + R+ + K E+ + K E +++ L+ R++ ++ R+ KR+ LL NLE+ E++ ++ Q + E A++L HE Q LE++Q + + D I+ QH E+ NQ+ Y + E +++++H+ EV+ PK LK KE +I++Q++D IQ +Q+K LR L + K +L+ L++E+ RK A L QY++SI D L Q K +D TQ E L++E +L+ +Q + H H + L+ R++ R+ALLE I+++ QN R + TL +RQA E+++FD+ + RLG N
Sbjct: 444 HFATIRTASLV------TRQIQEH---EQGSALREQMTGYKRMRRQHQKQLLALENKLKTEMDEHQLRLDKELESQRNNFGSEADKLSKKHQAILEKETKAALTEEKKFQQHILGQQKKELTGLLESQKRQYRQRKEQLKEELNENQSTPKREKQEWLVRQKECLQQIQAEEEAGLLRRQRQYYELQCRQYKRKMLLARHNLEQDLLREELNKRQTQKDLECAMLLRHHESTQELEFRQLGLVQHTRADLIRTQHQSELANQMDYNKRREQELRQKHNMEVRQQPKSLKTKELQIKRQFQDTCKIQTRQYKALRNHLLETTPKS----------EHKAVLKRLKEEQTRKLAILAEQYDHSINDMLSTQAVSKLRLDETQEAEYQVLRMQLQQELELLNAYQSKIKMHTDTQHDREVKDLEQRVSIRRALLEQRIEEEMLSLQNERSERIRTLLERQAREIEAFDSESMRLGFSN 899
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002962.1 (pep scaffold:Pmarinus_7.0:GL476671:16080:33623:-1 gene:ENSPMAG00000002691.1 transcript:ENSPMAT00000002962.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 345.51 bits (885), Expect = 1.345e-102 Identity = 159/310 (51.29%), Postives = 220/310 (70.97%), Query Frame = 2
Query: 167 PDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
P+++ LF +DP ++ DL++IG G+FGAVY+ARNI T E+VAIK++ GK+ E W+DI +EV+FL +L H N + YKGCYL++ AW++M+YCLGS +D+LEVHK+ L+E EIA + L GL +LH + IHRD+KA NIL+T+ G +K+ DFGS S +PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA NDSP L P WS +F +F+ S LQK+ RP++ L+ F + VL +MI RTK+AV + K++K+L+
Sbjct: 15 PEVAELFFKEDPEKLFCDLKEIGHGSFGAVYFARNIHTSEVVAIKKMSYSGKQSN---EKWQDIIKEVKFLTKLKHPNIIEYKGCYLREHTAWMIMEYCLGSASDLLEVHKKPLQEIEIAAIAHGALQGLAFLHNHTMIHRDVKAGNILLTEPGQVKLADFGSASLTAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSP-EWSDYFRNFVDSCLQKNGQDRPTSAGLLRHAFVMRDRPESVLIEMIQRTKDAVRELDNLQYRKMKKLLF 319 HSP 2 Score: 123.25 bits (308), Expect = 1.102e-28 Identity = 74/248 (29.84%), Postives = 136/248 (54.84%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLG 3043
+A++L HE Q LE++ + R++ + I+ QH E+ NQ++Y E +++++H E++ PK L++KE +I+KQ++D +Q +Q+K LR L + K +L+ L+DE+ RK A L QYE++I+ + Q ++D Q E L++E +L+ +Q + H + L+ +++ R+ALLE I+++ Q R + +L +RQA E++ FD+ + RLG
Sbjct: 712 HAMLLRHHEATQDLEFRHLNTVQRMRSELIRLQHQTELANQMEYNKGRERELRRKHVMEIRQQPKCLRVKEIQIKKQFQDTCKVQTRQYKALRNHLLETTPKG----------DHKAVLKRLKDEQTRKLAILAEQYEHTINEMMSTQALRLDEAQEGECQALKVQLQQELELLNAYQSKIKMRTDAQHERERKELEQKVSLRRALLEQKIEEEMVALQTERSDKIRSLLERQAREIELFDSESVRLG 949
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002959.1 (pep scaffold:Pmarinus_7.0:GL476671:15807:33413:-1 gene:ENSPMAG00000002691.1 transcript:ENSPMAT00000002959.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 345.895 bits (886), Expect = 1.932e-102 Identity = 162/323 (50.15%), Postives = 225/323 (69.66%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R ++ P+++ LF +DP ++ DL++IG G+FGAVY+ARNI T E+VAIK++ GK+ E W+DI +EV+FL +L H N + YKGCYL++ AW++M+YCLGS +D+LEVHK+ L+E EIA + L GL +LH + IHRD+KA NIL+T+ G +K+ DFGS S +PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA NDSP L P WS +F +F+ S LQK+ RP++ L+ F + VL +MI RTK+AV + K++K+L+
Sbjct: 1 MPSNSRAGSLRD-PEVAELFFKEDPEKLFCDLKEIGHGSFGAVYFARNIHTSEVVAIKKMSYSGKQSN---EKWQDIIKEVKFLTKLKHPNIIEYKGCYLREHTAWMIMEYCLGSASDLLEVHKKPLQEIEIAAIAHGALQGLAFLHNHTMIHRDVKAGNILLTEPGQVKLADFGSASLTAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSP-EWSDYFRNFVDSCLQKNGQDRPTSAGLLRHAFVMRDRPESVLIEMIQRTKDAVRELDNLQYRKMKKLLF 317 HSP 2 Score: 125.176 bits (313), Expect = 2.863e-29 Identity = 75/251 (29.88%), Postives = 137/251 (54.58%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+A++L HE Q LE++ + R++ + I+ QH E+ NQ++Y E +++++H E++ PK L++KE +I+KQ++D +Q +Q+K LR L + K +L+ L+DE+ RK A L QYE++I+ + Q ++D Q E L++E +L+ +Q + H + L+ +++ R+ALLE I+++ Q R + +L +RQA E++ FD+ + RLG N
Sbjct: 653 HAMLLRHHEATQDLEFRHLNTVQRMRSELIRLQHQTELANQMEYNKGRERELRRKHVMEIRQQPKCLRVKEIQIKKQFQDTCKVQTRQYKALRNHLLETTPKG----------DHKAVLKRLKDEQTRKLAILAEQYEHTINEMMSTQALRLDEAQEGECQALKVQLQQELELLNAYQSKIKMRTDAQHERERKELEQKVSLRRALLEQKIEEEMVALQTERSDKIRSLLERQAREIELFDSESVRLGFSN 893
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865]) HSP 1 Score: 199.904 bits (507), Expect = 5.539e-53 Identity = 110/279 (39.43%), Postives = 167/279 (59.86%), Query Frame = 2
Query: 227 QIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLG-SVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGS----VSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASN--DSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKN 1042
++G G +G V+ ARN+ T E+VAIK IK++ +D+ I +E+ ++E H N ++Y G YL+ W+ M++C G S+ DI V L E +IA V E L GL YLH G +HRDIK +NIL+TD G +K+ DFG + I+ SF+GTP+W+APEV G YN + DVW++GIT IE+AE++PP F L+PM A++ ++ + PKL D WS F++F+ L K+P +RP+A L + + +SR +++ R +
Sbjct: 19 RLGSGTYGDVHKARNVQTGELVAIKIIKLEPG------DDFSVIQQEIVMMKECKHTNIVAYYGSYLRHDKLWICMEHCGGGSLQDIYHV-TGPLTERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNHQCDVWAVGITAIELAELQPPMF-DLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKMLTHSYVQQPLSRAQALELLERVSD 289
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66]) HSP 1 Score: 199.904 bits (507), Expect = 2.152e-52 Identity = 106/291 (36.43%), Postives = 156/291 (53.61%), Query Frame = 2
Query: 197 DPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKE-SLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFG----SVSFISPANSFVGTPFWIAPEVILA--MESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAV 1048
DP +++ + ++G G FG VY A+N + + A + E+ ED E+ L DH N + + + W+ +++C G D + + E L E +I V ++L L YLH + IHRD+KA NIL+T +G +K+ DFG + + +SF+GTP+W+APEV++ M+ Y+ K D+WSLGIT IE+A+MEPP LNPM M +IA ND P L+ P WS F FL L K+P+ R +A LQ F S L ++IA K V
Sbjct: 28 DPAELWSVIGELGDGAFGKVYKAQNKESGVLAA------AKVIETKSEEELEDYMVEIEILALCDHPNIVGLLNAFYYENKLWIFIEFCPGGAVDAIMLELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVSAKNTRTLQRRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPN-HELNPMRVMLKIAKNDPPSLSFPSKWSAEFTDFLKKCLDKNPETRWNALQLLQHSFISGVDSNKPLRELIAEAKAEV 311
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92]) HSP 1 Score: 176.022 bits (445), Expect = 7.578e-48 Identity = 110/288 (38.19%), Postives = 161/288 (55.90%), Query Frame = 2
Query: 197 DPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIK--ASNILITDQGGIKIGDFGSVSFISPA----NSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPF-SRNNVSRDVLHQMIARTK 1039
DP ++T +IG G+FG V+ + T+E+VAIK I ++ + + E +E+ L + D Y G YLK W++M+Y G A L + L E +IA ++ E+L GL YLH IHRDIK A+N+L+++QG +K+ DFG ++ N+FVGTPFW+APEVI + Y+ K D+WSLGIT IE+A+ EPP L+PM ++ I N+ P L N+S F F+ S L K P RP+A + L+ F R+ L ++I R K
Sbjct: 21 DPEELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQ-----QEITVLSQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALDL-IKPGPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---KQSAYDFKADIWSLGITAIELAKGEPPN-SELHPMRVLFLIPKNNPPTLEG--NYSKAFKEFVDSCLNKDPQFRPTAKELLKHKFIQRSAKKTSYLTELIDRYK 296
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 187.578 bits (475), Expect = 2.035e-51 Identity = 122/320 (38.12%), Postives = 180/320 (56.25%), Query Frame = 2
Query: 179 SLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLG-SVADILE-VHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPA---NSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRN----NVSRDVLHQMIARTKNAVAAQETQM-SHKLRKMLYHCGN 1108
S+ + P+ +Y+ IG GNFG VY A + TQEIVAIK + ++ ED E +A+E+ FL EL +Y L+D + W+VM+YC G S +D+L+ + L E +++ ++ EV GL+YLH IHRDIKA+NIL+ ++G +K+GDFG I ++FVGTP+W+APEV+ G YNEK D+WSLGIT E+ + PP + +PM M + PKL P +S F+ L K+P RPSA++ L F +N N+ DV +I + K V + T++ + L+ LY N
Sbjct: 7 SIRSRTPPSKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSD-----EDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKRDTFVGTPYWMAPEVVCCEVDG-YNEKADIWSLGITTYELLKGLPP-LSKYDPMKVMTNLPKRKPPKLQGP--FSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVKNITITNLKSDV--DLIKQKK--VQERYTKVPKYPLQNRLYKNSN 313
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 173.711 bits (439), Expect = 1.748e-44 Identity = 108/296 (36.49%), Postives = 164/296 (55.41%), Query Frame = 2
Query: 170 DISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDH-KNCLSYKGCYLKDQNAWLVMDYCLG-SVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPAN----SFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSR--NNVSRDVLHQMIAR 1033
D+SSLF + IG G FG VY N+ T + AIK + +D S+ ++ ED+ RE++FL L N Y G YLKD + W++M++C G S+ +L K + E I ++ E+L L+ +H + IHRDIKA+N+LIT++G +K+ DFG + ++ + + GTP+W+APEVI ME Y+ KVD+WSLGIT E+A PPY + + AM I + P+L D ++S F+ L + P +R SA D L+ F R +L ++I+R
Sbjct: 18 DVSSLFKRTE---------VIGRGKFGVVYKGYNVKTGRVYAIKVLNLD-----SDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGK--IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVI--MEGVYYDTKVDIWSLGITTYEIATGNPPYC-DVEALRAMQLIIKSKPPRLED-RSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKELISR 293
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 172.555 bits (436), Expect = 2.667e-44 Identity = 104/272 (38.24%), Postives = 153/272 (56.25%), Query Frame = 2
Query: 173 ISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLG-SVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPAN----SFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDAL 973
++ + ++ DP+ Y +L +IG G G VY A I T VAIK++ + ++ E I E+ ++ H N +++ Y+ + W++M+Y G S+ D+ V L E +I V E L GL++LH G +HRDIK+ NIL++ +G IK+ DFG + I+ N + VGTP+W+APEV+ E Y KVD+WSLGI IEM E EPPY P+ A+Y IA+N +PKL +P N S FL L P+ R SA + L
Sbjct: 607 LNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNL------EKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDV--VTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKE---YGPKVDIWSLGIMIIEMIEGEPPYLNE-TPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELL 866
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 156.377 bits (394), Expect = 2.567e-39 Identity = 100/293 (34.13%), Postives = 158/293 (53.92%), Query Frame = 2
Query: 134 KPLRPSIFKER--PDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYAR--NISTQ----EIVA-------IXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLK-DQNAWLVMDYCLG-SVADILEVHKES------LRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANS----FVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLL 931
KP RP++ + + N DP+ + + + G G G+VY A +I T+ E++ + + + S++ E I E+ +++ HKN +++ YL+ D + W+VM++ G S+ DI+E + L E +IA +V E GL++LH IHRDIK+ N+L+ + +KI DFG + ++ S VGTP+W+APEV+ E Y+EK+DVWSLGI IEM E EPPY +P+ A+Y IA+N +PKL P + S+ FL+ L
Sbjct: 518 KPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQRE---YDEKIDVWSLGIMTIEMLEGEPPYLNE-DPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCL 806
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473]) HSP 1 Score: 149.443 bits (376), Expect = 1.267e-37 Identity = 98/288 (34.03%), Postives = 149/288 (51.74%), Query Frame = 2
Query: 197 DPTFIYTDLRQIGCGNFGAVYYARNISTQEI-----------VAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYL-KDQNAWLVMDYCLGS-VADILEV--------HKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANS----FVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPF 985
+P + + + G G GAVY ++ I + + E + + SE+ + I E+ + + +N +++ Y+ D+ W++M+Y G + DIL+ H L E+++A +V E GL++LH IHRDIK+ NIL+ QG +KI DFG ++ S VGTP+W+APE++ + G Y+EKVDVWSLGI IEM E EPPY +P+ A+Y IA+N SPKL P + S FL + LQ + + R S L F
Sbjct: 355 NPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIV--NQKG-YDEKVDVWSLGIMLIEMIEGEPPYLNE-DPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEF 638
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO44592 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RV75]) HSP 1 Score: 341.658 bits (875), Expect = 2.257e-101 Identity = 158/314 (50.32%), Postives = 216/314 (68.79%), Query Frame = 2
Query: 170 DISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLYHCGNG 1111
+ + LF + DP IY DLR+IG G+FGAVYYARN+ T E+VAIK++ GK+ +E W+DI +EV+FL++ +H+N +SYK C++K+ AWLVM+YCLGS +DILEVHK+ L+E EIA + + L GL YLH + IHRD+KA N+L+T+ G +K+ DFGS + SPANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA ND P L+ WS F F+ LQK P RP A ++ F +++ +I RTK AV A + K++KM+ G
Sbjct: 13 EYAGLFDDHDPEKIYADLREIGHGSFGAVYYARNVRTNEVVAIKKMSYSGKQS---QEKWQDIVKEVKFLKQCNHRNTISYKACHIKEHTAWLVMEYCLGSASDILEVHKKPLQELEIAAICADSLQGLHYLHSHEKIHRDVKAGNVLLTEDGTVKLADFGSAALCSPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDPPSLSTD-GWSQDFIKFVQLCLQKHPLDRPDAEQLIKHCFVSQKRPPNIIKDLIRRTKAAVRALDNMNYRKMKKMIMSEAPG 321 HSP 2 Score: 134.42 bits (337), Expect = 5.588e-32 Identity = 132/449 (29.40%), Postives = 235/449 (52.34%), Query Frame = 2
Query: 1847 EQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRK-----------WEADTKGEIKSAK----------------KNAKSESGSNNIQELIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHT--QRLGIDNYKVVSATSRQASSSVRSQ 3106
+Q+ KR+R H++QL+QLE + E + ++ L++++D KEL+KL H+ ++E++ K++ + E + LR + + K E K+AK K+ S + S +Q+ + + +ELRK +R+ L++ LEK E++ E Q E+ + +++ HE Q LE+K LH+L+ +Q + QH E NQ++Y Q E +++K+H E+K PK LK E I+KQYRDA IQ Q+K L+++ L R D K +++ R++ RK ADL QY+ SI + ++Q ++D Q++E + L+ E+ +LS +Q Q ++ H + L+D+++ R+ALLE + Q+ + + R L RQ EL+ FD++ + L ++K S TS + S++ ++
Sbjct: 437 DQLLVYKRMRQNHQRQLQQLENKLQAEMNDHRRQLDKEYDQMVHQFEKELDKLRTRHKAEVEQKVKQMQSDEKKLLRHIRDQQENEMKVFSSKQKAEYKAAKLQFKRDQANRSLYQGRKDNFSATQSRILQQKVQSHKEYLRLELRKFRRDQLVQRHALEKALIAEEMNKLEAQKEQSHQMLIRHHECTQELEFKHLAALHKLRREQQQHQHQTEWTNQMEYNKQAELELRKKHLSELKQQPKTLKQHEIRIKKQYRDAIRIQTLQYKALQKQILE--RTPRD--------QHKDMIKQFREDRMRKMADLAVQYDQSIAEMLQRQTLRLDEVQLKEQEEFRQKLQGEQELLSAYQSKQAMQLKAQHEREEKELQDKVSVRRALLEEKMMQETERLREMREQKQAILQSRQERELEDFDSNADIETLSTASWKQRSVTSMSSLSNLSTE 875
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9]) HSP 1 Score: 197.593 bits (501), Expect = 3.226e-56 Identity = 107/281 (38.08%), Postives = 168/281 (59.79%), Query Frame = 2
Query: 200 PTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYC-LGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPA----NSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMI 1027
P ++ L ++G G++G+V+ A + + ++VAIK++ VD D ++I +E+ +++ D + Y G Y K+ + W+VM+YC GSV+D++++ ++L E EI CV+ L GL+YLH IHRDIKA NIL+ +G K+ DFG ++ N+ +GTPFW+APEVI E G Y+ D+WSLGIT +EMAE +PPY ++PM A++ I + P DP WS F F++ L K+P++R +A + LQ F + +L MI
Sbjct: 20 PEEVFDVLEKLGEGSYGSVFKAMHKESGQVVAIKQVPVDT--------DLQEIIKEISMMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDLMKIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI--QEVG-YDCLADIWSLGITAMEMAEGKPPY-ADIHPMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSFIQGAKQISILSSMI 288
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO49047 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHW1]) HSP 1 Score: 189.504 bits (480), Expect = 1.584e-53 Identity = 111/320 (34.69%), Postives = 175/320 (54.69%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLG-SVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPA----NSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASND--SPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQ 1066
M PLR I + PD ++ + ++G G +G V+ AR I+T ++ A+K +KV +D+E I +E+ +++ H N ++Y G Y++ W+ M+YC G S+ D+ V E++I+ V E L GL YLH +HRDIK +NIL+T G +K+ DFG + I+ SF+GTP+W+APE+ +G Y+ K D+W++GIT IEMAE++PP F L+PM A+Y I P L + WS + F+ L K+P +RPSA L PF ++++ VL ++ R + + Q
Sbjct: 1 MSVPLRAQISRGNPDK-----------VFDLIEKVGGGTYGDVFKARVIATGDLAAVKVVKV------EPGDDFELIQQEIAMMQQCRHNNIINYIGAYMRRDKLWIGMEYCGGGSIQDVYCV-TGPCSETQISFVTVETLKGLAYLHEKSLMHRDIKGANILLTTNGEVKLADFGISARITETMKKRKSFIGTPYWMAPEMAAVERTGGYDLKCDIWAVGITAIEMAELQPPMF-DLHPMRALYIIGKKSFIPPTLKEKDKWSNEMHHFIKVALIKNPKKRPSADKMLTHPFCCRHLTKAVLQDLLDRYRRKSQEKNLQ 301
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO33667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRJ0]) HSP 1 Score: 189.889 bits (481), Expect = 1.146e-51 Identity = 114/298 (38.26%), Postives = 165/298 (55.37%), Query Frame = 2
Query: 173 ISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLG-SVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPA----NSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVA 1051
+ ++ + DP YT +IG G G VY A ++T VAIK++ + S++ E I E+ +RE H N ++Y YL + W+VM+Y G S+ D+ V + + E +IA V E L L++LH NG IHRDIK+ NIL+ G +K+ DFG + I+P ++ VGTP+W+APEV+ + Y +VDVWSLGI IEM E EPPY NP+ A+Y IA+N +P+L P S F FL L+ ++R SA + LQ PF + L +I K A +
Sbjct: 213 LRTIVSIGDPKKKYTKFEKIGQGASGTVYTAIEVATGHEVAIKQMNL------SQQPKKELIINEILVMRENKHPNIVNYVDSYLVGEELWVVMEYLAGGSLTDV--VTETCMDEGQIAAVCRECLQALEFLHSNGVIHRDIKSDNILLGMDGQVKLTDFGFCATITPEQNKRSTMVGTPYWMAPEVVTRKQ---YGPRVDVWSLGIMAIEMVEGEPPYLNE-NPLRALYLIATNGTPELAHPEKLSPVFKDFLAQSLEMDVEKRSSARELLQHPFLKQAKPLASLVPLILAAKEATS 498
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4]) HSP 1 Score: 180.259 bits (456), Expect = 2.192e-49 Identity = 107/286 (37.41%), Postives = 164/286 (57.34%), Query Frame = 2
Query: 197 DPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLG-SVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPA----NSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTK 1039
DP +++ L +IG G+FG V+ + T E+VAIK I ++ + + E +E+ L + D Y G YLK W++M+Y G S D+++ ++ E IA ++ EVL GL YLH +HRDIKA+N+L+++ G +K+ DFG ++ N+FVGTPFW+APEVI + Y+ K D+WSLGIT IE+A+ EPP L+PM ++ I N+ P+LT N+S F F++ L K P+ RP+A + L+ F + L ++I R K
Sbjct: 6 DPEKLFSKLERIGKGSFGEVFKGIDNRTNEVVAIKIIDLEEAEDEIEDIQ-----QEITVLSQCDSLYVTKYHGSYLKGTKLWIIMEYLGGGSALDLMKAG--NIEEFYIATILREVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQLTDTLNKRNTFVGTPFWMAPEVI---KQSAYDSKADIWSLGITAIELAKGEPPN-SDLHPMRVLFLIPKNNPPELTG--NFSKAFKEFVSLCLNKDPNDRPTAKELLKHRFIKTAKKNAYLVELIERHK 278
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: taok3a (TAO kinase 3 [Source:NCBI gene;Acc:101156330]) HSP 1 Score: 348.206 bits (892), Expect = 2.803e-103 Identity = 168/323 (52.01%), Postives = 222/323 (68.73%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R ++ K+ P++ LF DDP ++ DL +IG G+FGAVY+ARN + E+VAIK++ +GK+ E W+DI +EV+FL +L H N + YKGCYLKD AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRD+KA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y KVD+WSLGITCIE+AE +PP F +N M+A+Y IA NDSP L WS F SF+ L K P RPS+ + L+ F R + S +L +I RTK+AV + K++K+LY
Sbjct: 1 MPSSTRKAVPKD-PELGDLFFKDDPEDVFCDLHEIGHGSFGAVYFARNSYSNEVVAIKKMSYNGKQTT---EKWQDIIKEVKFLGQLRHPNTIEYKGCYLKDNTAWLVMEYCLGSASDLLEVHKKPLQEMEIAAITHGALLGLAYLHSHNMIHRDVKAGNILLTELGLVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYEGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNDSPTLQSN-EWSDIFRSFVDYCLLKIPQDRPSSGELLRHDFVRRDRSPRILLDLIQRTKDAVRELDNLQYRKMKKILY 317 HSP 2 Score: 124.02 bits (310), Expect = 2.542e-28 Identity = 80/255 (31.37%), Postives = 138/255 (54.12%), Query Frame = 2
Query: 2300 NALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVV 3064
+A+++ E Q LE +Q +NL +L+MD I+ QH E+ENQ++Y + E ++ ++H E++ PK LK+ E +I+KQ++D +Q KQ+K LR ++ A K +L+ L+DE+ RK A L QYE SI+ + Q ++D Q E L++E +L+ +Q + + H + L+ +++ R+A LE I+++ Q R + L +RQ E+ SFD + RLG N ++
Sbjct: 648 HAMLIRHDESTQELEQRQLKNLQKLRMDLIRLQHQTELENQIEYNNRRERELHRKHVLELRQQPKNLKVLELQIKKQFQDTCKVQTKQYKALRHHQMEVTPKA----------EHKTVLKALKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHEREQQKLEQKVSLRRAHLEQKIEEELGSLQKERTDRIKHLLERQEREIDSFDMESMRLGFSNLGIL 892
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: taok1b (serine/threonine-protein kinase TAO1 [Source:NCBI gene;Acc:101163990]) HSP 1 Score: 345.51 bits (885), Expect = 2.215e-101 Identity = 163/322 (50.62%), Postives = 223/322 (69.25%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKML 1093
MP +R K+ P+++ LF +DP +++DLR+IG G+FGAVY+A ++ T E+VAIK++ GK+ E W+DI +EV+FL+ + H N + YKGCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRD+KA NIL+T+ G +K+ DFGS S SPANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L +WS +F +F+ S LQK P RP + D L F + VL +I RTK+AV + K++K+L
Sbjct: 1 MPSSIRAGSLKD-PEVAELFFKEDPEKLFSDLREIGHGSFGAVYFAWDVRTNEVVAIKKMSYSGKQSN---EKWQDIIKEVKFLQRIRHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGQVKLADFGSASIASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQSS-DWSDYFRNFVDSCLQKIPQDRPHSDDMLGHAFLQRERPESVLMDLIQRTKDAVRELDNLQYRKMKKIL 316 HSP 2 Score: 139.428 bits (350), Expect = 5.023e-33 Identity = 138/472 (29.24%), Postives = 249/472 (52.75%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKELTN-LETQT----LRKWEADTK-GEIKSAKKNAKSESGSN---NIQE--------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+FAT++T+ ++ + QE ++ ++ REQM+G KR+R QH+K L LE + E + + L+++ ++ R N +E+EKL HQ LEK +KKEL++ LE+Q LRK + + E +S K K E S NIQ L+ +++ +E R+ KR L+ N+E+ E++ ++ Q + E+A++L HE +Q LE++ + + + D I+ QH+ E+ NQ +Y + + +++++H+ EV+ PK LK KE +I+KQ ++ Q++Q+K L+ L + K +L+ L++E++RK A L QY++SI+ + Q ++D Q E L++E +L+ +Q + H ++ L+ R++ R+ALLE I+++ QN R + +L +RQA E+++FD+ + RLG N
Sbjct: 438 HFATIRTASLV------TREIQEH---EQDSELREQMSGYKRMRRQHQKHLMALENKLKGEMDEHRLRLDKELESQRNNFTQEMEKLLKKHQAALEKDVKTFANDEKKFQQHIQGQQKKELSSFLESQKREYKLRKEQLKEELSENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRKQRQYLELECRRFKRRILIARHNVEQDLAREELNKRQTQKDLEHAMLLRHHESMQELEFRHLATIQKARADLIRTQHETELTNQHEYNRRRKRELRRKHAMEVRQQPKSLKSKELQIKKQCQETCKTQRRQYKALKNHLLETTPKS----------EHKAVLKRLKEEQKRKLAILAEQYDHSINEMLSTQALRLDEAQEGEGQVLDMQLQQELELLNAYQSKIKMQTDAQHEKERRELEQRVSLRRALLEQKIEEEMLSLQNERLERIRSLLERQAREIEAFDSESLRLGFSN 890
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: ENSORLT00000006223.2 (serine/threonine-protein kinase TAO1 [Source:NCBI gene;Acc:101166893]) HSP 1 Score: 343.969 bits (881), Expect = 2.481e-101 Identity = 161/323 (49.85%), Postives = 223/323 (69.04%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
MP R K+ PD++ LF +DP ++TDL++IG G+FGAVY+AR++ T ++VAIK++ GK+ E W+DI +EV+FLR + H N + YKGC+L++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRDIKA NIL+T+ G +K+ DFGS S PANSFVGTP+W+APEVILAM+ G Y+ KVD+WSLGITCIE+AE +PP F +N M+A+Y IA N+SP L W+ F +F+ S LQK P +RP++ + L+ F + VL +I RTK+AV + K +K+L+
Sbjct: 1 MPNSSRAGCLKD-PDVAELFFKEDPEKLFTDLQEIGHGSFGAVYFARDVRTNDVVAIKKMSYLGKQST---EKWQDIIKEVKFLRRIKHPNSIEYKGCFLRETTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITDGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIACPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPTLQST-EWTDDFGNFVESCLQKIPQERPNSEELLKHSFVQRKRPESVLTDLINRTKDAVRELDNLQYRKRKKILF 317 HSP 2 Score: 142.124 bits (357), Expect = 8.196e-34 Identity = 139/478 (29.08%), Postives = 244/478 (51.05%), Query Frame = 2
Query: 1721 PPPGAGTSNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKEL-TNLETQT----LRKWEADTK-GEIKSAKKNAKSESGSN---NIQ--------ELIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGI 3046
P +FAT++T+ ++ + +E ++ ++ R+QM G KR+R QH+KQL LE + E + + L+++ +N R N +E++KL HQ ++K +KKEL +ETQ LRK + + E +S K K E S N+Q EL R++ E R+ ++ L+ N+EK +E++ ++ Q + E+A++L HE +Q LE++ + + + + + QH E+ NQL+Y + E +++++H+ EV+ PK LK KEQ+I+KQ++D IQ +Q+K LR L K +LE L E++RK A L QY+ +I + Q ++D TQ + L+KE+ +L+ +Q + ++ H + L+DR+A R+ LLE I+++ FQ + L +RQA ++++FD+ + RLG
Sbjct: 423 PKRTVNREHFATIRTASVL------TRQIKEH---EQDSELRQQMLGYKRMRRQHQKQLMALENKLKAEIDEHRLRLDKELENQRNNFAQEMDKLVKKHQASMDKETKTFCNDEKKFQQNIQSQQKKELNIFIETQKREYKLRKEQLKEELNEHQSTPKKKKQEWLSKQKENLQVYQAAKEAELQRRQRDFLEQECRRFNKKKLIERHNIEKDLLQEELNKRQTQKDLEHAMLLRHHESMQELEFRHLNTIQKTRSELTRLQHQTELLNQLEYNKKMERELRRKHAMEVRQQPKCLKSKEQQIKKQFQDTCKIQTRQYKALRNHLLETTPKC----------EHKAVLERLMVEQQRKLAILAEQYDQTISEMFSTQTLRLDETQEAQRQTLIMQLQKEQELLNAYQSKIKMQIEAHHEREKRHLEDRVALRRGLLEQKIKEEMHAFQKEHQERTRRLLERQARQVEAFDSESMRLGF 881
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: ENSORLT00000007838.2 (serine/threonine-protein kinase TAO2 [Source:NCBI gene;Acc:101155230]) HSP 1 Score: 345.895 bits (886), Expect = 1.783e-100 Identity = 165/324 (50.93%), Postives = 228/324 (70.37%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLYH 1099
MP +R K+ P+++ LF+ +DP ++TDLR+IG G+FGAVY+A +I T E+VAIK++ GK+ E W+DI +EV+FL++L H N + Y GCYL++ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRD+KA NIL+T+ G +K+GDFGS S I+PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L +WS +F +F+ S LQK RP++ L+ F V+ +IARTK+AV + K++K+L+H
Sbjct: 1 MPSSVRAGSLKD-PEVAELFSREDPEKLFTDLREIGHGSFGAVYFAHDIRTNEVVAIKKMSYSGKQSN---EKWQDIIKEVKFLQKLRHPNTVEYHGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLVYLHSHNMIHRDVKAGNILLTEPGQVKLGDFGSASIIAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPVLQSN-HWSDYFRNFVDSCLQKLAQDRPTSDVLLKHHFLCRERPMTVVMDLIARTKDAVRELDNLQYRKMKKILFH 318 HSP 2 Score: 164.466 bits (415), Expect = 1.214e-40 Identity = 143/472 (30.30%), Postives = 242/472 (51.27%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKELTNL---ETQTLRKWEADTKGEIKSAKKNAKSESGSNNIQE--------------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDN 3052
+FAT++T+ ++ + QE ++ + REQM+G KR+R QH+KQL LE + E + + L+++ +N R N + E EKL HQ EK +KKELT L + + R+ + K E+ + K E + + L+ R++ ++ R+ KR+ LL NLE+ E + ++ + E A++L HE Q LE++Q + R + D I+ QH E+ NQ++Y + E +++++H+ EV+ PK LK KE +I++Q++D IQ +Q+K LR L N + K +L+ L+DE+ RK A L QY++SI+ + Q ++D TQ E L++E +L+ +Q + H H + L+ R++ R+ALLE I+++ QN R + TL +RQASE+++FD+ + RLG N
Sbjct: 444 HFATIRTASLV------TRQIQEH---EQGSALREQMSGYKRMRRQHQKQLMGLENKLKAEMDEHQLRLDKELENQRNNFSMEAEKLSKKHQAIQEKELKATQTEEKKFQQHILGQQKKELTTLIDSQKRQYRQRKEQLKEELNENQSTPKREKQEWLVHQKECLQQLQAEEEAGLLRRQRQYYELQCRQYKRKMLLSRHNLEQDLLREDLNKKQTLKDLECAMLLRHHESTQELEFRQLSVVQRTRADLIRTQHQTELTNQMEYNKRREQELRQKHAMEVRQQPKSLKSKELQIKRQFQDTCKIQTRQYKALRNHLLE----------NTPKSDHKAVLKRLKDEQTRKLAILAEQYDHSINDMLSTQALRLDETQEAEYKVLRMQLQQELELLNAYQSKIKIHTDTQHEREVKDLEQRVSIRRALLEQRIEEEMLALQNERSERIRTLLERQASEIEAFDSESLRLGFSN 896
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: taok2a (serine/threonine-protein kinase TAO2 [Source:NCBI gene;Acc:101169206]) HSP 1 Score: 341.658 bits (875), Expect = 3.928e-99 Identity = 161/310 (51.94%), Postives = 218/310 (70.32%), Query Frame = 2
Query: 167 PDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLY 1096
PD + LF DDP ++ DLR+IG G+FGAVY+AR++ E+VAIK++ GK+ E W+DI +EV+FL++L H N + Y+GCYLK+ AWLVM+YCLGS +D+LEVHK+ L+E EIA + L GL YLH + IHRD+KA NIL+T+ G +K+GDFGS S ++PANSFVGTP+W+APEVILAM+ G Y+ KVDVWSLGITCIE+AE +PP F +N M+A+Y IA N+SP L +WS F +F+ S LQK P RP++ L F V+ +IARTK+AV + K++K+L+
Sbjct: 13 PDAAELFCKDDPEKLFADLREIGHGSFGAVYFARDVRNNEVVAIKKMSYSGKQTN---EKWQDIIKEVKFLQKLRHPNTIEYRGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGQVKLGDFGSASIVAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPILQSN-HWSDSFRNFVDSCLQKIPQDRPTSDVLLNHRFLCRERPLTVVMDLIARTKDAVRELDNLQYRKMKKILF 317 HSP 2 Score: 141.739 bits (356), Expect = 1.141e-33 Identity = 137/480 (28.54%), Postives = 244/480 (50.83%), Query Frame = 2
Query: 1745 NFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-------------------RKKELTNL---ETQTLRKWEADTKGEIKSAKKNAKSESGSNNIQE--------------LIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSI-DALKRQQNDK--IDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVS 3067
+FAT++T+ ++ + QE ++ + REQM+G KR+R QH+KQL LE + E + + L+++ +N R + + E +KL HQ LEK +KKELT L + + R+ + K E+ + K E +++ L+ R++ ++ R+ +R+ LL NLE+ E++ ++ Q + E A++L HE Q LE++Q + R + + I+ QH E+ NQ +Y + + +++++H+ E + PK LK KE +I++Q+++ IQ +Q+K L+ L + + NI L+ L++E+ RK A L QY +SI D L Q K ++ TQ E + L++E +L+ +Q + H H + L+ R++ R+ALLE I+++ QN R + TL +RQA E+++FD+ + RLG N +
Sbjct: 438 HFATIRTASLV------TRQIQEH---EQGSALREQMSGYKRMRRQHQKQLMGLENKLKAEMDEHQLKLDKELENQRNSFSTEADKLVKKHQAILEKETKAALAEEKKFQQHILGQQKKELTGLLDSQKRQYRQRKEQLKEELSENQLTPKREKQEWLVRQKECLQQMQAEEEASLLRRQRQYYELQCRQYRRKMLLAHHNLEQDLLREELNKKQTQKDLECAMLLRHHESTQELEFRQLSLVQRTRAELIRTQHQTELTNQKEYNERRKQELQQKHATEARQQPKSLKSKELQIKRQFQETGKIQTRQYKALKNHLLESTPKSEHKNI----------LKRLKEEQTRKLAILSEQYNHSINDMLSTQAVTKLRLNETQEAEEQVLNMQLQQELELLNAYQSKIKMHTDTQHEREIKDLEQRVSIRRALLEQRIEEEMLSLQNERSERIRTLLERQAHEIEAFDSESMRLGFSNMALTG 898
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000074970.1 (SMESG000074970.1) HSP 1 Score: 1864.35 bits (4828), Expect = 0.000e+0 Identity = 1023/1023 (100.00%), Postives = 1023/1023 (100.00%), Query Frame = 2
Query: 128 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLYHCGNGTHHCSSHQEXXXXXXXXXXXXXXXXDISSYCATDDTASLSDTCERRGXXXXXXXXXXXXXXXXXXHELLPILHASAMISSSSETGFPGRHFANAPXXXXXXXXXXXXNGALHRTSSDNYAGXXXXXXXXXXXXXQFAAGDMNATNKSVLVRTNRSQNKSTGDVSESKTSMISPSRIMPGQISQQPLIENMISHLDISDPSVLYPPPGAGTSNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEIKSAKKNAKSESGSNNIQELIDRRQTLTNVXXXXXXXXXXXXIQNXXXXXXXXXXXXXXXXXXXXNALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASSSVRSQMPXXXXXXXXXXXXXXMPDWRHSRADFMPS 3196
MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIKEIKVDGKKKKSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLYHCGNGTHHCSSHQEANSSSTRTSATAEDSSDISSYCATDDTASLSDTCERRGSCSNSCASHSSSLSDGISHELLPILHASAMISSSSETGFPGRHFANAPSSSGQSSVSSTSNGALHRTSSDNYAGSPSSHLNNSHPSSQFAAGDMNATNKSVLVRTNRSQNKSTGDVSESKTSMISPSRIMPGQISQQPLIENMISHLDISDPSVLYPPPGAGTSNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEIKSAKKNAKSESGSNNIQELIDRRQTLTNVELRKLKRESLLRIQNLEKQQTEEKIKLQEKQLERENALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASSSVRSQMPGAGGGHGNGAGGRAMPDWRHSRADFMPS
Sbjct: 1 MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIKEIKVDGKKKKSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQETQMSHKLRKMLYHCGNGTHHCSSHQEANSSSTRTSATAEDSSDISSYCATDDTASLSDTCERRGSCSNSCASHSSSLSDGISHELLPILHASAMISSSSETGFPGRHFANAPSSSGQSSVSSTSNGALHRTSSDNYAGSPSSHLNNSHPSSQFAAGDMNATNKSVLVRTNRSQNKSTGDVSESKTSMISPSRIMPGQISQQPLIENMISHLDISDPSVLYPPPGAGTSNFATLKTSRMMKGSHAFSAAFQERLGPQKQADWREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEKRKKELTNLETQTLRKWEADTKGEIKSAKKNAKSESGSNNIQELIDRRQTLTNVELRKLKRESLLRIQNLEKQQTEEKIKLQEKQLERENALMLSQHEKLQALEYKQKENLHRLKMDQIKKQHDLEMENQLQYAAQEEAQIKKRHSHEVKNLPKYLKLKEQEIRKQYRDAASIQKKQFKILREERLRAMRNAADVNINNHAINEKQLLENLRDEERRKQADLESQYENSIDALKRQQNDKIDSTQIQELTKCHDDLEKEKNMLSEFQRLQQEHMQQSHVEDYNALKDRIAKRKALLETTIQQKNDEFQNRRRINLTTLFDRQASELKSFDNHTQRLGIDNYKVVSATSRQASSSVRSQMPGAGGGHGNGAGGRAMPDWRHSRADFMPS 1023
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000046962.1 (SMESG000046962.1) HSP 1 Score: 387.882 bits (995), Expect = 2.186e-121 Identity = 185/293 (63.14%), Postives = 229/293 (78.16%), Query Frame = 2
Query: 182 LFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQE 1060
L DDP+ I+T+L+QIGCG+FGAVYYA+NI T+EI+AIKEIKVD K S+++ W+DI RE+ L++L+H NC+S+KG YLK N +VMDYCLGSV+DI+EV K+ L+E EI CVV EVL L YLH IHRDIKASNIL+T+ G +K+GDFGS SF++PAN+FVGTPFWIAPEVI+AMESGLY+ KVD+WSLGITCIEMAEMEPP+F+ LNPMAAMY IASNDSP L +P WS F + + L+KSPD RPSA +ALQ F +L +MI +NAVAA+E
Sbjct: 7 LLCKDDPSTIFTNLKQIGCGSFGAVYYAQNIKTKEIIAIKEIKVDSK---SQKDHWKDIKREICLLKQLNHVNCISFKGYYLKGNNPLIVMDYCLGSVSDIIEVFKKPLQEDEIGCVVVEVLKALNYLHKKNFIHRDIKASNILLTECGLVKLGDFGSSSFVNPANTFVGTPFWIAPEVIMAMESGLYDFKVDIWSLGITCIEMAEMEPPHFKTLNPMAAMYHIASNDSPCLLNPSLWSNEFVFLVVAFLKKSPDNRPSAENALQSKFCTIKRPPFILLKMIKNARNAVAARE 296 HSP 2 Score: 70.8626 bits (172), Expect = 3.759e-12 Identity = 40/83 (48.19%), Postives = 56/83 (67.47%), Query Frame = 2
Query: 1841 WREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-----RKKELT---NLET 2065
WREQMNGLKR+R+QHK+ ++QLEE++ E E K L+R+ +N +KELEKL + ++L+K R+KEL NLET
Sbjct: 474 WREQMNGLKRIRNQHKRSIQQLEEKHKNELETTKFLLSRELENVTTTFHKELEKLNKTNSLELDKNNKESRQKELNFVKNLET 556
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000046962.1 (SMESG000046962.1) HSP 1 Score: 388.267 bits (996), Expect = 2.388e-121 Identity = 185/293 (63.14%), Postives = 229/293 (78.16%), Query Frame = 2
Query: 182 LFTNDDPTFIYTDLRQIGCGNFGAVYYARNISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLGSVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPANSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASNDSPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPFSRNNVSRDVLHQMIARTKNAVAAQE 1060
L DDP+ I+T+L+QIGCG+FGAVYYA+NI T+EI+AIKEIKVD K S+++ W+DI RE+ L++L+H NC+S+KG YLK N +VMDYCLGSV+DI+EV K+ L+E EI CVV EVL L YLH IHRDIKASNIL+T+ G +K+GDFGS SF++PAN+FVGTPFWIAPEVI+AMESGLY+ KVD+WSLGITCIEMAEMEPP+F+ LNPMAAMY IASNDSP L +P WS F + + L+KSPD RPSA +ALQ F +L +MI +NAVAA+E
Sbjct: 16 LLCKDDPSTIFTNLKQIGCGSFGAVYYAQNIKTKEIIAIKEIKVDSK---SQKDHWKDIKREICLLKQLNHVNCISFKGYYLKGNNPLIVMDYCLGSVSDIIEVFKKPLQEDEIGCVVVEVLKALNYLHKKNFIHRDIKASNILLTECGLVKLGDFGSSSFVNPANTFVGTPFWIAPEVIMAMESGLYDFKVDIWSLGITCIEMAEMEPPHFKTLNPMAAMYHIASNDSPCLLNPSLWSNEFVFLVVAFLKKSPDNRPSAENALQSKFCTIKRPPFILLKMIKNARNAVAARE 305 HSP 2 Score: 70.8626 bits (172), Expect = 4.154e-12 Identity = 40/83 (48.19%), Postives = 56/83 (67.47%), Query Frame = 2
Query: 1841 WREQMNGLKRLRSQHKKQLKQLEERNAVEEENLKQALNRDFDNTRQNHNKELEKLEAVHQVDLEK-----RKKELT---NLET 2065
WREQMNGLKR+R+QHK+ ++QLEE++ E E K L+R+ +N +KELEKL + ++L+K R+KEL NLET
Sbjct: 483 WREQMNGLKRIRNQHKRSIQQLEEKHKNELETTKFLLSRELENVTTTFHKELEKLNKTNSLELDKNNKESRQKELNFVKNLET 565
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000029685.1 (SMESG000029685.1) HSP 1 Score: 195.667 bits (496), Expect = 8.492e-51 Identity = 111/303 (36.63%), Postives = 169/303 (55.78%), Query Frame = 2
Query: 173 ISSLFTNDDPTFIYTDLRQIGCGNFGAVYYA---RN--ISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLG-SVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPA----NSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASND--SPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPF-SRNNVSRDVLHQMIARTKN 1042
+ DP Y ++ IG G +G VY A RN +S +IV + ++D + IA+E+ LR+ +HKN + Y G YL+ W+ M++C G S+ DI + L E+ IA V + L GL Y+H G IHRDIK +NIL+T+ G +KI DFG + I+ SF+GTP+W+APEV G Y+EK D+W++GIT IE AE++PP F L+PM A++ ++ + +P L + WS F+SFL L K+ +RP A LQ F ++ N++ + ++ +N
Sbjct: 14 LEEFIIKKDPKEDYKLIKNIGSGTYGEVYKAIHRRNNTVSAVKIVKVDI-----------KDDIKAIAQEIHTLRDCNHKNIVKYFGSYLRKNKLWICMEFCGGFSIQDIYTNIRRPLEENCIAYVTRDTLDGLAYMHKQGKIHRDIKGANILLTEDGQVKIADFGVAAQITQTIQKRCSFIGTPYWMAPEVAAVERKGGYDEKCDIWAVGITAIEYAELQPPMF-DLHPMKALHLLSMRNYKAPVLQNKTKWSQKFHSFLKICLNKNEKRRPDAMTLLQHDFVTQKNLTISLTKHLLQVNRN 304
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000029685.1 (SMESG000029685.1) HSP 1 Score: 195.667 bits (496), Expect = 9.016e-51 Identity = 111/303 (36.63%), Postives = 169/303 (55.78%), Query Frame = 2
Query: 173 ISSLFTNDDPTFIYTDLRQIGCGNFGAVYYA---RN--ISTQEIVAIXXXXXXXXXXXSEREDWEDIAREVRFLRELDHKNCLSYKGCYLKDQNAWLVMDYCLG-SVADILEVHKESLRESEIACVVTEVLCGLQYLHGNGHIHRDIKASNILITDQGGIKIGDFGSVSFISPA----NSFVGTPFWIAPEVILAMESGLYNEKVDVWSLGITCIEMAEMEPPYFRRLNPMAAMYQIASND--SPKLTDPLNWSIHFNSFLTSLLQKSPDQRPSAFDALQMPF-SRNNVSRDVLHQMIARTKN 1042
+ DP Y ++ IG G +G VY A RN +S +IV + ++D + IA+E+ LR+ +HKN + Y G YL+ W+ M++C G S+ DI + L E+ IA V + L GL Y+H G IHRDIK +NIL+T+ G +KI DFG + I+ SF+GTP+W+APEV G Y+EK D+W++GIT IE AE++PP F L+PM A++ ++ + +P L + WS F+SFL L K+ +RP A LQ F ++ N++ + ++ +N
Sbjct: 12 LEEFIIKKDPKEDYKLIKNIGSGTYGEVYKAIHRRNNTVSAVKIVKVDI-----------KDDIKAIAQEIHTLRDCNHKNIVKYFGSYLRKNKLWICMEFCGGFSIQDIYTNIRRPLEENCIAYVTRDTLDGLAYMHKQGKIHRDIKGANILLTEDGQVKIADFGVAAQITQTIQKRCSFIGTPYWMAPEVAAVERKGGYDEKCDIWAVGITAIEYAELQPPMF-DLHPMKALHLLSMRNYKAPVLQNKTKWSQKFHSFLKICLNKNEKRRPDAMTLLQHDFVTQKNLTISLTKHLLQVNRN 302 The following BLAST results are available for this feature:
BLAST of Serine/threonine kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Serine/threonine kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30009769 ID=SMED30009769|Name=Serine/threonine kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=3516bpback to top protein sequence of SMED30009769-orf-1 >SMED30009769-orf-1 ID=SMED30009769-orf-1|Name=SMED30009769-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1024bp MPKPLRPSIFKERPDISSLFTNDDPTFIYTDLRQIGCGNFGAVYYARNISback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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