epidermal growth factor receptor 1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30009712 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 40
Homology
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 257.299 bits (656), Expect = 4.523e-69 Identity = 152/483 (31.47%), Postives = 240/483 (49.69%), Query Frame = 2
Query: 2219 QCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
QC D ++ CT+C + CV CP F AD +CHPCHP C GC G + CI+ + LP++ L + I V V L+ + RK +K+ L+ + + E + + + PN L ++ L+ + ++LG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GV + +L ++ MP G + +Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 532 QCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-----------AGVIGGLFILVIVGLT------------------------FAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 959 HSP 2 Score: 197.593 bits (501), Expect = 2.064e-50 Identity = 162/597 (27.14%), Postives = 260/597 (43.55%), Query Frame = 2
Query: 236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
NC V GN+ I +++ DL FL ++E+TG + + + +PL NLR+IRG ++LY + AL D + + + L++L I++G +Y+ ++F + W +++ +P ++T T + C + K +G CWGP + CQ ++ C RC+ D CC+ +C GGC+ + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + + C PC +C + C S S ++D + K NCT G + + + + L +R I+G +++++ P + S SNL I V SL I+ I+ L +SLK I I+ +N+ LCY+ + + T+N +I DN A+ C G VC+ C S GCWGPGP+ C+SC G IC E+C + G ++ S +C++C +C K TC G D C C H + CV +C F+ K + C PCH +C
Sbjct: 29 NCEVVMGNLEITSIEHNR-----DLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRKAEN--CTAEGMVCNHLCSSD-GCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGS-ICVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNC 595
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 257.299 bits (656), Expect = 4.717e-69 Identity = 152/483 (31.47%), Postives = 240/483 (49.69%), Query Frame = 2
Query: 2219 QCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
QC D ++ CT+C + CV CP F AD +CHPCHP C GC G + CI+ + LP++ L + I V V L+ + RK +K+ L+ + + E + + + PN L ++ L+ + ++LG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GV + +L ++ MP G + +Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 558 QCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-----------AGVIGGLFILVIVGLT------------------------FAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985 HSP 2 Score: 197.593 bits (501), Expect = 2.103e-50 Identity = 173/650 (26.62%), Postives = 282/650 (43.38%), Query Frame = 2
Query: 77 WIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
W+++ LL++ + SDS + SS+ L+ Y L++ NC V GN+ I +++ DL FL ++E+TG + + + +PL NLR+IRG ++LY + AL D + + + L++L I++G +Y+ ++F + W +++ +P ++T T + C + K +G CWGP + CQ ++ C RC+ D CC+ +C GGC+ + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + + C PC +C + C S S ++D + K NCT G + + + + L +R I+G +++++ P + S SNL I V SL I+ I+ L +SLK I I+ +N+ LCY+ + + T+N +I DN A+ C G VC+ C S GCWGPGP+ C+SC G IC E+C + G ++ S +C++C +C K TC G D C C H + CV +C F+ K + C PCH +C
Sbjct: 8 WVWVS-LLVAAGTVQPSDSQSVCAGTENKLSSLSDLE----QQYRALRKYY-ENCEVVMGNLEITSIEHNR-----DLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRKAEN--CTAEGMVCNHLCSSD-GCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGS-ICVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNC 621
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 256.529 bits (654), Expect = 7.211e-69 Identity = 152/483 (31.47%), Postives = 240/483 (49.69%), Query Frame = 2
Query: 2219 QCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
QC D ++ CT+C + CV CP F AD +CHPCHP C GC G + CI+ + LP++ L + I V V L+ + RK +K+ L+ + + E + + + PN L ++ L+ + ++LG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GV + +L ++ MP G + +Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 558 QCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-----------AGVIGGLFILVIVGLT------------------------FAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985 HSP 2 Score: 196.438 bits (498), Expect = 4.636e-50 Identity = 173/650 (26.62%), Postives = 282/650 (43.38%), Query Frame = 2
Query: 77 WIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
W+++ LL++ + SDS + SS+ L+ Y L++ NC V GN+ I +++ DL FL ++E+TG + + + +PL NLR+IRG ++LY + AL D + + + L++L I++G +Y+ ++F + W +++ +P ++T T + C + K +G CWGP + CQ ++ C RC+ D CC+ +C GGC+ + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + + C PC +C + C S S ++D + K NCT G + + + + L +R I+G +++++ P + S SNL I V SL I+ I+ L +SLK I I+ +N+ LCY+ + + T+N +I DN A+ C G VC+ C S GCWGPGP+ C+SC G IC E+C + G ++ S +C++C +C K TC G D C C H + CV +C F+ K + C PCH +C
Sbjct: 8 WVWVS-LLVAAGTVQPSDSQSVCAGTENKLSSLSDLE----QQYRALRKYY-ENCEVVMGNLEITSIEHNR-----DLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRKAEN--CTAEGMVCNHLCSSD-GCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGS-ICVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNC 621
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB2 (erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:3430]) HSP 1 Score: 241.121 bits (614), Expect = 1.646e-64 Identity = 153/489 (31.29%), Postives = 250/489 (51.12%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC---NG---CYGVDKNHCIHCNNF------------------------KLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSP--PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVL--NHSCDQN-EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN 3637
C C + +CV C +V L + N+ C PCHP+C NG C+G + + C+ C ++ K P+ E +C + CP N + + ++ C L +I AVV + ++ L ++ R+ K ++ ++ + TPS PN + ++ L + ++LG G FG+VY G W D ++ K+ V IKVL N S N E +DE +MA V + RL+G+ + +L ++ MP G + ++ +N+ L + LL W QIA GM YLE+ ++HRDLA RNVL+ NHV+ITDFGL+++++ ++ E GG VP++W+A+E++ ++H++DVW+Y VT+WE+ TF PY+ + A EI D + KG RL QP IC++D+Y++M+KCW +D E RP F L +EF + + + ++ N
Sbjct: 528 CVNCSQFLRGQECVEEC-RVLQGLPREYVNAR--HCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEG----AC-QPCPINCTHSCVDLDDKGCP-AEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKV---KVLGSGAFGTVYKGIWIPDG------------ENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL-VTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN 991 HSP 2 Score: 170.629 bits (431), Expect = 3.555e-42 Identity = 153/590 (25.93%), Postives = 249/590 (42.20%), Query Frame = 2
Query: 182 LDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDIS-VSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETG-DEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQE-GECKTQCTFRKYERQGD----QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES-LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVREC 1906
L S ++ + L+ L C V GN+ + + + ++ L FL I+E+ G + I ++ + VPL+ LR++RG + ++ L N ++ ++ S + LRSL I+ G + I + Q C + W ++ + ++T T + C C K CWG + CQ ++ +CA C + +CC+ QC GCT S C+AC + +C+ CP N +T PN R F C+ CP L + G C C E + +C C C ++C + + + ++ +++ A C G + ESF + L+ E L I+G +YI P L LS NLQ I ++ + SLT+ IS+LGL+SL+ + + +NT LC+ + + + + + + N D C G C C ++ CWGPGP C++C+ G C E C V G L ++ CL CH EC + TC G +DQC+ C H + CV C
Sbjct: 35 LPASPETHLDMLRH-LYQGCQVVQGNLELTYLPTNAS-----LSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQ-DTILWKDIFHKNNQLALTLIDTNRSRAC-HPCSPMCKGSRCWGESSEDCQSLTR---TVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVR----AVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYI--SAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNP--HQALLHTANRPEDE--CVGEGLACHQLC-ARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQG-LPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCV-ACAHYKDPPFCVARC 600
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB2 (erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:3430]) HSP 1 Score: 240.35 bits (612), Expect = 1.671e-64 Identity = 152/485 (31.34%), Postives = 249/485 (51.34%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC---NG---CYGVDKNHCIHCNN------------------------FKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSP--PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVL--NHSCDQN-EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C C + +CV C +V L + N+ C PCHP+C NG C+G + + C+ C + +K P+ E +C + CP N + + ++ C L +I AVV + ++ L ++ R+ K ++ ++ + TPS PN + ++ L + ++LG G FG+VY G W D ++ K+ V IKVL N S N E +DE +MA V + RL+G+ + +L ++ MP G + ++ +N+ L + LL W QIA GM YLE+ ++HRDLA RNVL+ NHV+ITDFGL+++++ ++ E GG VP++W+A+E++ ++H++DVW+Y VT+WE+ TF PY+ + A EI D + KG RL QP IC++D+Y++M+KCW +D E RP F L +EF + + + ++
Sbjct: 252 CVNCSQFLRGQECVEEC-RVLQGLPREYVNAR--HCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEG----AC-QPCPINCTHSCVDLDDKGCP-AEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKV---KVLGSGAFGTVYKGIWIPDG------------ENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL-VTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFV 711 HSP 2 Score: 89.7373 bits (221), Expect = 2.842e-17 Identity = 73/249 (29.32%), Postives = 109/249 (43.78%), Query Frame = 2
Query: 1178 LKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES-LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVREC 1906
+++ A C G + ESF + L+ E L I+G +YI P L LS NLQ I ++ + SLT+ IS+LGL+SL+ + + +NT LC+ + + + + + + N D C G C C ++ CWGPGP C++C+ G C E C V G L ++ CL CH EC + TC G +DQC+ C H + CV C
Sbjct: 85 IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISA--WPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNP--HQALLHTANRPED--ECVGEGLACHQLC-ARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQG-LPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCV-ACAHYKDPPFCVARC 324
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 406.371 bits (1043), Expect = 4.813e-120 Identity = 379/1329 (28.52%), Postives = 588/1329 (44.24%), Query Frame = 2
Query: 239 CTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDK-----CVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
C VYGN+ I +++ ES S D + F ++EI GSL I +NI + LRVI GD HD+ AL I ++ + V+ +R LR I +G++ I + C ++W ELL DP Q V + T + C Q GKS CWG + CQ ++ + C+ +CF S T ECC+S CLGGCT +CIAC + +C CP +KI N +TG N R N C+ +CP LL + C C+ Y+ D +C C+ C +ICT++ L LK L C QID ++H + LK LE ++ +S YI + F L FL NLQ IE + + +L I D+ L L SLK+IK A+ N +LCY + +I+ + ++ ++ D KLCE VC C+ + GCWG P C+ C + C E C + G+L N TS C +C EC +TC+GL C+ C+H N M CV +C +HF + CE CH C+ CTGP + G GGC +C+ + + + C Q++ +N + + +I + VI C +C+I S + + CK + C+ CP V +F+ D N+ KCH Q C C C NF + + + + CV CP N ++ + E C+ ++ + ++ + + F + + F L + +R K + + TP PNM+ + +I S L+ + + LG G FG+V+AG + K+ K+ V IKV Q +E ++E M +RH + L++IG +++ Y PLG+++ +L+ +K++L + + + QIA+GM YLE ++HRDLATRNVL+ K NHV+ITDFGLSKI+ + D + I G V ++WLAIE Y+H +DVWA+ VT WEI TF PY+ + I + + G RL QP CS D+Y +L+CW DP+ RP FE L+ FK + + +L N E+ + T F+ I+ + + D+ ++ PH NR++ + + R + P + + V ++ +N + SNG D++++P+ +PSS + Y EP
Sbjct: 5 CRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1232
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 407.142 bits (1045), Expect = 5.468e-120 Identity = 393/1388 (28.31%), Postives = 610/1388 (43.95%), Query Frame = 2
Query: 86 LHILLISLIFYRYSDSLIEYPEIKYCFSSMDLL-----DGSQSSNYNTLKQDLGN---NCTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDK-----CVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
L I+ I L F+ S++ + K C S D L +G + +DL C VYGN+ I +++ ES S D + F ++EI GSL I +NI + LRVI GD HD+ AL I ++ + V+ +R LR I +G++ I + C ++W ELL DP Q V + T + C Q GKS CWG + CQ ++ + C+ +CF S T ECC+S CLGGCT +CIAC + +C CP +KI N +TG N R N C+ +CP LL + C C+ Y+ D +C C+ C +ICT++ L LK L C QID ++H + LK LE ++ +S YI + F L FL NLQ IE + + +L I D+ L L SLK+IK A+ N +LCY + +I+ + ++ ++ D KLCE VC C+ + GCWG P C+ C + C E C + G+L N TS C +C EC +TC+GL C+ C+H N M CV +C +HF + CE CH C+ CTGP + G GGC +C+ + + + C Q++ +N + + +I + VI C +C+I S + + CK + C+ CP V +F+ D N+ KCH Q C C C NF + + + + CV CP N ++ + E C+ ++ + ++ + + F + + F L + +R K + + TP PNM+ + +I S L+ + + LG G FG+V+AG + K+ K+ V IKV Q +E ++E M +RH + L++IG +++ Y PLG+++ +L+ +K++L + + + QIA+GM YLE ++HRDLATRNVL+ K NHV+ITDFGLSKI+ + D + I G V ++WLAIE Y+H +DVWA+ VT WEI TF PY+ + I + + G RL QP CS D+Y +L+CW DP+ RP FE L+ FK + + +L N E+ + T F+ I+ + + D+ ++ PH NR++ + + R + P + + V ++ +N + SNG D++++P+ +PSS + Y EP
Sbjct: 11 LLIIPIFLTFFGNSNAQL----WKRCVSPQDCLCSGTTNGISRYGTGNILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1293
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 405.216 bits (1040), Expect = 3.359e-119 Identity = 379/1329 (28.52%), Postives = 589/1329 (44.32%), Query Frame = 2
Query: 239 CTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWF-----DDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
C VYGN+ I +++ ES S D + F ++EI GSL I +NI + LRVI GD HD+ AL I ++ + V+ +R LR I +G++ I + C ++W ELL DP Q V + T + C Q GKS CWG + CQ ++ + C+ +CF S T ECC+S CLGGCT +CIAC + +C CP +KI N +TG N R N C+ +CP LL + C C+ Y+ D +C C+ C +ICT++ L LK L C QID ++H + LK LE ++ +S YI + F L FL NLQ IE + + +L I D+ L L SLK+IK A+ N +LCY + +I+ + ++ ++ D KLCE VC C+ + GCWG P C+ C + C E C + G+L N TS C +C EC +TC+GL C+ C+H N M CV +C +HF + CE CH C+ CTGP + G GGC +C+ + + + C Q++ +N + + +I + VI C +C+I S + + CK + + C+ CP V +F+ D N+ KCH Q C C C NF + + + + CV CP N ++ + E C+ ++ + ++ + + F + + F L + +R K + + TP PNM+ + +I S L+ + + LG G FG+V+AG + K+ K+ V IKV Q +E ++E M +RH + L++IG +++ Y PLG+++ +L+ +K++L + + + QIA+GM YLE ++HRDLATRNVL+ K NHV+ITDFGLSKI+ + D + I G V ++WLAIE Y+H +DVWA+ VT WEI TF PY+ + I + + G RL QP CS D+Y +L+CW DP+ RP FE L+ FK + + +L N E+ + T F+ I+ + + D+ ++ PH NR++ + + R + P + + V ++ +N + SNG D++++P+ +PSS + Y EP
Sbjct: 78 CRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1305
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 405.216 bits (1040), Expect = 3.438e-119 Identity = 379/1329 (28.52%), Postives = 588/1329 (44.24%), Query Frame = 2
Query: 239 CTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDK-----CVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
C VYGN+ I +++ ES S D + F ++EI GSL I +NI + LRVI GD HD+ AL I ++ + V+ +R LR I +G++ I + C ++W ELL DP Q V + T + C Q GKS CWG + CQ ++ + C+ +CF S T ECC+S CLGGCT +CIAC + +C CP +KI N +TG N R N C+ +CP LL + C C+ Y+ D +C C+ C +ICT++ L LK L C QID ++H + LK LE ++ +S YI + F L FL NLQ IE + + +L I D+ L L SLK+IK A+ N +LCY + +I+ + ++ ++ D KLCE VC C+ + GCWG P C+ C + C E C + G+L N TS C +C EC +TC+GL C+ C+H N M CV +C +HF + CE CH C+ CTGP + G GGC +C+ + + + C Q++ +N + + +I + VI C +C+I S + + CK + C+ CP V +F+ D N+ KCH Q C C C NF + + + + CV CP N ++ + E C+ ++ + ++ + + F + + F L + +R K + + TP PNM+ + +I S L+ + + LG G FG+V+AG + K+ K+ V IKV Q +E ++E M +RH + L++IG +++ Y PLG+++ +L+ +K++L + + + QIA+GM YLE ++HRDLATRNVL+ K NHV+ITDFGLSKI+ + D + I G V ++WLAIE Y+H +DVWA+ VT WEI TF PY+ + I + + G RL QP CS D+Y +L+CW DP+ RP FE L+ FK + + +L N E+ + T F+ I+ + + D+ ++ PH NR++ + + R + P + + V ++ +N + SNG D++++P+ +PSS + Y EP
Sbjct: 71 CRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1298
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: R151.1 (pep chromosome:WBcel235:III:7218813:7221186:1 gene:WBGene00020106.1 transcript:R151.1c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R151.1) HSP 1 Score: 173.326 bits (438), Expect = 6.738e-46 Identity = 94/282 (33.33%), Postives = 161/282 (57.09%), Query Frame = 2
Query: 2792 IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASV-RHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKK------SLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSN 3607
I+ G ++G+G FG V+ G + NG + V +K L + ++ EF+ E+++M +V +H + + + G + +I Y+P G ++ YL+ +K ++ K L + QIA GM +LE+ IIHRDLA RN+L+ ++I+DFG+S+ P +++ G++P+RWL+ E ++D YS+K+DVWA+ V LWEI T PY + +I +++ +G RL QP CS D+YILM CW++ E+RP+F + ++ + +N
Sbjct: 189 IVVGAVIGEGAFGQVFKGILRGPNG-------------QVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSR---PGV-YIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKIEQIAN 453
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071654) HSP 1 Score: 489.189 bits (1258), Expect = 1.097e-148 Identity = 356/1217 (29.25%), Postives = 573/1217 (47.08%), Query Frame = 2
Query: 140 EYPEIKYCFSSMDLLD--GSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQD---ISVSNSIKTVIDLRSLRSIVSGNIYISSQF-CSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHR---------PEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES--LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-DSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCY--QNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADE-TNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKL-PENE-----NLTLFSCVESCP-----SNYKETSGN--------------SNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLAR-KGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYP 3634
E+ + K C + L ++ +Y L+ D NCT+V GN+ + + +E+ DL FL I+E+TG + I + ++ V L++IRG + F +S++++ + V+ S +++ LR +++G + + + + ++W+E++ + T T +C K C + G CWG CQ FSK C + RC+ + ECC+ C GGCT CIAC+ D VC+ ECPP + N T + E N + + C+ +CP LL G C C K ++ G +CVPC C + C + + + NCT G ++I ++F + P +P+ + + L+ ++ I+G Y++++ + +LS+ NL+ I L+ + +L I+ + + L +++LK I + ++ ++N LCY ++ I K +++N AD LCE+ G +CS QC+ GCWG G + C++C N C +C GY++N ++ C CH EC +TC+G +D C C H + CV EC + + ++ C CH C CTGP +T G G C C I+ D V+RC + +GYF + + CH LC CT + C++C Y ++C + CP AD T+ +C CHP+CNGC G + C C NFKL NE N T+F+C CP NY+ T+ +N ++ + ++G L + ++T C + K K++ K+ S +S+ PS N + + E GG +LG G FG VY G W + ++ K+ V IK L S EF+ E IMASV H + L+L+ V S+ +LI+ MPLG + Y+ N+ + K LL W+ QIA GM YLE ++HRDLA RNVL+ + V+ITDFGL+K+++ + +E + GG +P++WLA+E +R+ +++ K+DVWA+ VT+WE+ TF P+E + A +I D I G +L QP+ICSLDIY +L CW +D RP F+ L T F ++ + YL+ P
Sbjct: 95 EFVKGKICIGTKSRLSVPSNKEHHYRNLR-DRYTNCTYVDGNLELTWLPNENL----DLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRG-------------RTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPK-CHESCTHG-CWGEGPKNCQKFSKLTCSPQCAGGRCYGPKP--RECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDK-GGECVPCNGPCPKTCPGVTVLHAGN------------IDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPL-DPERLEVFSTVKEITG--YLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEP--EQKVWVNENLRAD--LCEKNGTICSDQCNED-GCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAYKFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKYNDR--GVCRECHATCDG--------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGR-----AVCRKCHPLCELCTNYGYHE--------QVCSKCTHYKRREQCETECP-------ADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITG----------AVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGG-VLGMGAFGRVYKGVWVPEG------------ENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMS-SQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIP 1208
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071653) HSP 1 Score: 487.649 bits (1254), Expect = 1.676e-148 Identity = 355/1214 (29.24%), Postives = 571/1214 (47.03%), Query Frame = 2
Query: 152 IKYCFSSMDLLD--GSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQD---ISVSNSIKTVIDLRSLRSIVSGNIYISSQF-CSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHR---------PEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES--LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-DSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCY--QNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADE-TNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKL-PENE-----NLTLFSCVESCP-----SNYKETSGN--------------SNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLAR-KGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN 3637
+K C + L ++ +Y L+ D NCT+V GN+ + + +E+ DL FL I+E+TG + I + ++ V L++IRG + F +S++++ + V+ S +++ LR +++G + + + + ++W+E++ + T T +C K C + G CWG CQ FSK C + RC+ + ECC+ C GGCT CIAC+ D VC+ ECPP + N T + E N + + C+ +CP LL G C C K ++ G +CVPC C + C + + + NCT G ++I ++F + P +P+ + + L+ ++ I+G Y++++ + +LS+ NL+ I L+ + +L I+ + + L +++LK I + ++ ++N LCY ++ I K +++N AD LCE+ G +CS QC+ GCWG G + C++C N C +C GY++N ++ C CH EC +TC+G +D C C H + CV EC + + ++ C CH C CTGP +T G G C C I+ D V+RC + +GYF + + CH LC CT + C++C Y ++C + CP AD T+ +C CHP+CNGC G + C C NFKL NE N T+F+C CP NY+ T+ +N ++ + ++G L + ++T C + K K++ K+ S +S+ PS N + + E GG +LG G FG VY G W + ++ K+ V IK L S EF+ E IMASV H + L+L+ V S+ +LI+ MPLG + Y+ N+ + K LL W+ QIA GM YLE ++HRDLA RNVL+ + V+ITDFGL+K+++ + +E + GG +P++WLA+E +R+ +++ K+DVWA+ VT+WE+ TF P+E + A +I D I G +L QP+ICSLDIY +L CW +D RP F+ L T F ++ + YL+ P
Sbjct: 50 MKVCIGTKSRLSVPSNKEHHYRNLR-DRYTNCTYVDGNLELTWLPNENL----DLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRG-------------RTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPK-CHESCTHG-CWGEGPKNCQKFSKLTCSPQCAGGRCYGPKP--RECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDK-GGECVPCNGPCPKTCPGVTVLHAGN------------IDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPL-DPERLEVFSTVKEITG--YLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEP--EQKVWVNENLRAD--LCEKNGTICSDQCNED-GCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAYKFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKYNDR--GVCRECHATCDG--------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGR-----AVCRKCHPLCELCTNYGYHE--------QVCSKCTHYKRREQCETECP-------ADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITG----------AVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGG-VLGMGAFGRVYKGVWVPEG------------ENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMS-SQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPG 1160
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Shark (gene:FBgn0015295 transcript:FBtr0087244) HSP 1 Score: 203.371 bits (516), Expect = 4.590e-53 Identity = 112/298 (37.58%), Postives = 168/298 (56.38%), Query Frame = 2
Query: 2726 SQTPSPPNMNHLLVISSDNLEFIMGGEIL------GKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVL-NHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLK-WAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIF-GGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEF 3592
S TPS P+ + + L F + E L G G FGSV++G W L + ++S+++V IK+L + ++ EF+ E +M + HK +RLIG++ KG +++ PLGSM +Y+ + +T LK WA QIA GM YLE+ H +HRDLA RN+L+ + +I+DFG+S+ + P E Q GG P+RW A E+ GI+SH +DVW++ VT+WE+F+ PY + + + G RL QP++C IY +M CW P++RP F YL TEF
Sbjct: 637 SGTPSTPSATE---VEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKS--------GAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIA-KGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYL-TEF 920
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0330693) HSP 1 Score: 176.407 bits (446), Expect = 6.199e-47 Identity = 102/294 (34.69%), Postives = 157/294 (53.40%), Query Frame = 2
Query: 2735 PSPPNMNHLLVISSDNLEF----IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNH-SCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGK--ILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGM-VPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEF 3592
P PP +S D E +M E LG G FG V GKW+ +D +K++ + +++F++E ++M ++H + ++L GV K +++ YM GS+ YL +++K+L G +LL Q++ GM YLE ++ IHRDLA RN L+ EN V++ DFGL++ + D+ GG P++W E L +S K+DVWAY V +WEIFT +PY LK E+ + + +G L +P C+ +IY +M CWS PEERP F L +
Sbjct: 185 PVPPTAG----LSHDKWEIHPMELMLMEELGSGQFGVVRRGKWR-----------------GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 455
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0330692) HSP 1 Score: 178.333 bits (451), Expect = 1.010e-46 Identity = 102/294 (34.69%), Postives = 157/294 (53.40%), Query Frame = 2
Query: 2735 PSPPNMNHLLVISSDNLEF----IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNH-SCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGK--ILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGM-VPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEF 3592
P PP +S D E +M E LG G FG V GKW+ +D +K++ + +++F++E ++M ++H + ++L GV K +++ YM GS+ YL +++K+L G +LL Q++ GM YLE ++ IHRDLA RN L+ EN V++ DFGL++ + D+ GG P++W E L +S K+DVWAY V +WEIFT +PY LK E+ + + +G L +P C+ +IY +M CWS PEERP F L +
Sbjct: 286 PVPPTAG----LSHDKWEIHPMELMLMEELGSGQFGVVRRGKWR-----------------GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 556
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: egfra (epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) [Source:ZFIN;Acc:ZDB-GENE-030918-1]) HSP 1 Score: 254.603 bits (649), Expect = 1.080e-68 Identity = 148/432 (34.26%), Postives = 224/432 (51.85%), Query Frame = 2
Query: 2732 TPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIR--NLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
TPS PN L ++ + I ++LG G FG+V+ G W + ++ K+ V IKVL + E MDE +MASV H H RL+G+ + +L I+ MP G + Y+ +NK + + LL W QIA GM YLE H++HRDLA RNVL+ HV+ITDFGL+K++N ++ E GG VP++W+A+E+++ Y+H++DVW+Y VT+WE+ TF T PY+ + A EI + KG RL QP IC++D+Y++M+KCW +D E RP F L EF + + YL + Q +D + +P R + G + + +VP H F + P LL+ +++LN SF GN N + + P V +S+ + Y+ T R
Sbjct: 692 TPSGEAPNQALLRILKETEFKKI---KVLGSGAFGTVHKGLWVPEG------------ENVKIPVAIKVLREATSPKANKEIMDEAYVMASVEHPHVCRLLGICLTSTVQL-ITQLMPYGCLLDYVRENKDRIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESIQHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFTKMARDPSRYL-------------------VIQGDDRMHLPSPSDSKFYRSLMSGELDEAVDADEYLVPNH--SFFSSPSTSRTQLLH---------SVSLNSSF----GNCNSRNGNGYP-VRENSMVLRYIPDPTERF 1072 HSP 2 Score: 194.512 bits (493), Expect = 1.177e-49 Identity = 179/662 (27.04%), Postives = 286/662 (43.20%), Query Frame = 2
Query: 101 ISLIF-YRYSDSLIEYPEIKYCFSSMDLLD--GSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIY--ISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDE--ECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYE-RQGD--QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNK---------ITKTCEPCHKDCHSRSITRLPVCTGP 2008
I L F S S PE K C + + L G+ +Y L + + NCT V N+ I ++ + DL FL I+E+ G + I + +S +PL NLR+IRG S LY A+ ++ SI+Q + + L SL I+ G + +++ C+ + +EW ++L + ++ C K C +G CWG +CQ +K +CA +C G +CCN C GCT + C+AC+ D C+ CP + + T PN Y + F C+ CP ++ G C C+ YE +G +C C+ LC ++C + + S++ + NCT G V I + +F + L L ++ I+G + I L P + SLS NL+ I T S + T I++LG++SL+ I + + N LCY + +K + K+ V +I + D C + + C+ C + GCWGPGP C C + G C +C + G + +K C++C EC +TC+G D+C C + + CV C + K +T C+PCH++C CTGP
Sbjct: 7 IGLFFTLLLSGSFCATPEKKVCQGANNKLTLLGTVEDHYQVLLR-MYRNCTVVLENLEITHITEKY-----DLSFLKSIQEVGGYVLIAVNTVSKIPLENLRIIRGHS-LYEDKFALAVLVNYNNSIEQGVKE-------LPLTSLTEILKGGVRFNMNNHLCN-VGTIEWADILNMKSLPTIVSHNISYGKNCGK-CDPSCFNGSCWGTGPDKCQRMTKV---ICAEQCSGRCKGPRPIDCCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQLAPNPYGKYSFGATCIKTCPHNYVVTDHGACVRTCSPGTYEVDEGGVRKCKRCEGLCPKVCNGLGMGPLANV----LSINATNIDSFENCTKISGNVAILSTTFRGDPHTNTSGLDPAKLSVLSTVKEITGYLMIQL--WPESMQSLSAFENLEVIRGRTKTQGTYSFAVTKTAITHLGMRSLREISDGDVSIVKNKNLCYSSPEHWKRLFKSKQ-QSVKMIEN---MDAATCANQNSTCNEMCTAD-GCWGPGPTMCFGCEHYSRGKHCVASCNLLNGEPREYE-VNKTCMECDPECLLMNETQTCNGPGPDKCT-VCANYKDGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENCTQG-------CTGP 629
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64]) HSP 1 Score: 244.202 bits (622), Expect = 1.250e-67 Identity = 115/297 (38.72%), Postives = 180/297 (60.61%), Query Frame = 2
Query: 2744 PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
PN L ++ L+ + +ILG G FG+VY G W + + K+ V IK+LN S EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ +++ ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NH++ITDFGL++++ N+ E G +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 12 PNQAQLRILKETELKRV---KILGTGAFGTVYKGIW------------VPEGETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYL 292
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4]) HSP 1 Score: 248.825 bits (634), Expect = 8.851e-67 Identity = 119/327 (36.39%), Postives = 195/327 (59.63%), Query Frame = 2
Query: 2657 LARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
+ RK +K+ L+ + + E + + + PN L ++ L+ + +ILG G FG VY G W + + K+ V IK+LN S EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ +++ ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NH++ITDFGL+++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + +I D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 460 IRRKSIKKKRALRRFLETELVEPLTPSGAAPNQAQLRILKETELKRV---KILGAGAFGMVYKGIWVPEG------------ETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYL 770 HSP 2 Score: 141.739 bits (356), Expect = 2.081e-33 Identity = 114/434 (26.27%), Postives = 186/434 (42.86%), Query Frame = 2
Query: 761 CANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQ---CVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSITRLPVCTGP 2008
C RCF + CC+ +C GGC + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + +Q C+PC +C ++C + + + ++D ++K NCT G + + + D L +R I+G +++++ P + L SNL I SL I+ I+ L +SL+ I ++ NN++LC++ + ++ +T T +I +N +P+ C + +C C S+ GCWGPGP+ C+SC G C ++C + G + + VC++C +C K TC G D C+ C H + CV +C F+ K +T C PCH +C CTGP
Sbjct: 12 CDGRCFGPYVSN--CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCTDICPKVC---DGIGTGSLQMAQ-TVDSSNIEKFVNCTKINGNLIFLITGIKGDMFHGIRALDPDRLNVFRTVREITG--FLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQR--ALIKNN--REPRECSKEQKICDPLC-SEAGCWGPGPDQCLSCKYFSRGKTCVKSCNLYYGDVRE-FANGSVCVECDSQCEKAGEKGLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQG-------CTGP 423 HSP 3 Score: 60.4622 bits (145), Expect = 1.830e-8 Identity = 88/317 (27.76%), Postives = 131/317 (41.32%), Query Frame = 2
Query: 236 NCTHVYGNI--FINNVKSES----NGSEPD-LEFLSGIKEITGSLKIRN--SNISSVPL-RNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS--SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKK---CMQKGKSGFCWGPLTSQ---CQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPK--KIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEI 1126
NCT + GN+ I +K + +PD L ++EITG L +++ N++ + + NL I G S LY+ S+ L+ + S+ +SLR I +GN+Y++ SQ C + V W L T++++ K +P +CSK+ C CWGP Q C+ FS R + C C L E N C DS A + L C P K ++ + G PN C+ KCP+GL +G KY ++C PC C Q CT I
Sbjct: 153 NCTKINGNLIFLITGIKGDMFHGIRALDPDRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIGGRS-LYSGISLLILKQRWITSLQ--------------FQSLREISAGNVYMTNNSQLC-FYSTVNWTSLFRTSTQRALI-KNNREPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYFS--RGKTCVKSCNLYYGDVREFANGSV---CVECDSQCEKAGEKGL---TCHGPGPDHCVKCLHLKDG---PN----------CVEKCPDGL---QG---ANSFIFKYAETNNECHPCHPNCTQGCTGPRI 425
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4]) HSP 1 Score: 248.825 bits (634), Expect = 1.531e-66 Identity = 154/494 (31.17%), Postives = 251/494 (50.81%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK----VRTFL-KADETNSSLGKCHPCHPQC-NGCYGVDKNHC-------------IHCNNFKLPENENLTLFSCVESCPS-NYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
SQC ++ ++ C +C CV CP +F+ K ETN+ +CHPCHP C G ++ C + N L N +F V C ++ G + + L G ++VI+A+ + RK +K+ L+ + + E + + + PN L ++ L+ + +ILG G FG VY G W + + K+ V IK+LN S EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ +++ ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NH++ITDFGL+++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + +I D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 530 SQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNN---ECHPCHPNCTQGSVACNRFRCRTRILYRTSCDNPMQSYNCSLDRNMFDAMFLNVTYCTGPRIQDCVGILDRTPLIAAGLIGGLFVIVIIALGVAVY------------IRRKSIKKKRALRRFLETELVEPLTPSGAAPNQAQLRILKETELKRV---KILGAGAFGMVYKGIWVPEG------------ETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYL 992 HSP 2 Score: 195.667 bits (496), Expect = 5.854e-50 Identity = 160/613 (26.10%), Postives = 273/613 (44.54%), Query Frame = 2
Query: 206 YNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQ---CVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSIT 1984
Y TL++ NC V GN+ I +++ N L FL I+E+TG + + + +PL NLR+IRG ++LY + +L D + + L++L I++G +Y+ ++F + W++++++P + + C K+C + +G CWG QCQ +K C RCF + CC+ +C GGC + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + +Q C+PC +C ++C + + + ++D ++K NCT G + + + D L +R I+G +++++ P + L SNL I SL I+ I+ L +SL+ I ++ NN++LC++ + ++ +T T +I +N +P+ C + +C C S+ GCWGPGP+ C+SC G C ++C + G + + S VC++C +C K TC G D C+ C H + CV +C F+ K +T C PCH +C S+
Sbjct: 19 YKTLRK-FYENCEVVMGNLEITSIERNRN-----LSFLKSIREVTGYVLVALNQFDYLPLENLRIIRG-TKLY--EGRYSLAIFLNYRRDGYFGLRQ-----LGLKNLTEILNGGVYVDQNKFLCHADTIHWHDIIKNPRSELLVVPSNNSGNTC-KRC-HRSCNGRCWGHQEDQCQSLTKTVCAEQCDGRCFGPYVSN--CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCTDICPKVC---DGIGTGSLQMAQ-TVDSSNIEKFVNCTKINGNLIFLITGIKGDMFHGIRALDPDRLNVFRTVREITG--FLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQR--ALIKNN--REPRECSKEQKICDPLC-SEAGCWGPGPDQCLSCKYFSRGKTCVKSCNLYYGDVREFANGS-VCVECDSQCEKAGEKGLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQGSVA 600
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64]) HSP 1 Score: 248.825 bits (634), Expect = 1.800e-66 Identity = 173/583 (29.67%), Postives = 271/583 (46.48%), Query Frame = 2
Query: 2213 CSQCTIRTDQRISLSKTDWKG---CTQCKGYWFDDKCVSIC----PKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN----------YKETS------------GNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETY----------LSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIV------PEHVQRF 3817
CSQ + D S+S G C CK + CV C VR F +C + C+G +HC+ C + K N CVE CP Y ET+ G + I + + ++ + +FV+ + + F + K+KR + + E + + + PN L ++ L+ + +ILG G FG+VY G W + + K+ V IK+LN S EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ +++ ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NH++ITDFGL++++ N+ E G +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + Y L PN + + + ++ DE Y PHS N I + NQ PE V RF
Sbjct: 495 CSQQRMVCDPLCSVSGCWGPGPNQCLSCKYFSRGRTCVRSCNLYNGDVREFANGSTCVECDSQCEKAEDKSLTCHGPGPDHCVKCLHLKDGPN-------CVEKCPDGLQGANSFIFKYPETNNECHPCHPNCTQGCTGPRIQDCIGILDRTPLIAAGVIGGMFVVVIVALGFAIFFRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KILGTGAFGTVYKGIWVPEG------------ETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNHSKFFQSLLDEEELDDLMDADE--YLVPHSLNAPPTSHIPHPHVDSNQNQFGYHDGSRCPEDVTRF 1052 HSP 2 Score: 196.052 bits (497), Expect = 5.678e-50 Identity = 178/668 (26.65%), Postives = 284/668 (42.51%), Query Frame = 2
Query: 77 WIYLHILLISLIF----YRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSITRLPVCTGP 2008
W +LL L+F + S P S++ LD Y TL++ NC V GN+ I +++ N L FL I+E+TG + + + +PL NLR+IRG ++LY + +L D + + LR+L I++G +Y+ ++F + W +++++P + + C ++C + +G CWGP QCQ +K C RCF + CC+ +C GGC + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + + C+ C +C ++C S S ++D ++K NCT G + + + + L +R I+G Y++++ P + LS SNL I SL I+ I+ L +SL+ I ++ NN++LC++ + ++ +T T I DN DP+ C Q+ VC C S GCWGPGPN C+SC G C +C + G + + C++C +C K TC G D C+ C H + CV +C F+ K +T C PCH +C CTGP
Sbjct: 2 WPVRFLLLFCLVFTFAVLQRSSGQSVCPGTDNKLSTLSDLD----QQYKTLRK-FYENCEVVMGNLEITSIERNRN-----LSFLKSIREVTGYVLVALNQFDYLPLENLRIIRG-TKLY--EGRYSLAIFLNYRRDGYFGLRQ-----LGLRNLTEILNGGVYVDQNKFLCHADTIHWQDIIKNPRSELLVVPSNNSGNTC-RRC-HRSCNGRCWGPQEDQCQSLTKTVCAEQCDGRCFGPYVSN--CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKTEVEENNIKMCIQCTEICPKMCDGIGTGS----LQSAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDMYHGIRALDPERLNVFRTVREITG--YLNIQSWPENMTDLSVFSNLVTIGGRTLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQK--AKIKDN--RDPRECSQQRMVCDPLC-SVSGCWGPGPNQCLSCKYFSRGRTCVRSCNLYNGDVRE-FANGSTCVECDSQCEKAEDKSLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYPETNNECHPCHPNCTQG-------CTGP 627
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 265.774 bits (678), Expect = 2.776e-72 Identity = 154/481 (32.02%), Postives = 243/481 (50.52%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK------VRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
SQC D ++ CT+C + CV CP+ F ADE +CHPCHP C +GC + C+ + LP++ L + S I V + L+ + RK +K+ L+ + + E + + + PN L ++ L+ I +ILG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GVS + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 378 SQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDK----ECHPCHPNCTDGCNNPTSHDCLWNDPLTLPQHARTPLIA-----------ASVIGGLFIIVIMALT------------------------FAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 803 HSP 2 Score: 150.214 bits (378), Expect = 7.072e-36 Identity = 128/454 (28.19%), Postives = 185/454 (40.75%), Query Frame = 2
Query: 662 KCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKIT---KTCEPCHKDC 1966
+C K CM G CWGP CQ +K C RC+ S D CC+ +C GGCT + C +C D+ C +CP I N E N + + C+NKCP + + C C K E + + C PC +C ++C S S ++D + K NCT G + + L +R I+G +++++ P + LS SNL I V SL I+ ++ L +SLK I ++ +N LCY+ + ++ +T N T I +N P+ C G VC C S GCWGPG N C+SC G C +C + G + VC+ C +C K TC G D C C + + CV +C F+ K K C PCH +C
Sbjct: 9 RCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGS----LQSAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNC 442
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 265.388 bits (677), Expect = 9.055e-72 Identity = 150/463 (32.40%), Postives = 241/463 (52.05%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSIC----PKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSG-----NSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C C+ + CV C + R F+ +C CYG +HC C+NFK N CVE CP + + + C F + G L+ +V+ + + + + RK +K+ L+ + + E + + + PN L ++ L+ I +ILG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GVS + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 525 CLSCRYFSRGKSCVRSCNLYKGESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPN-------CVEKCPEGLQGANSFIFKYADEDKECFFSCVVGTLTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 964 HSP 2 Score: 185.652 bits (470), Expect = 9.818e-47 Identity = 160/602 (26.58%), Postives = 249/602 (41.36%), Query Frame = 2
Query: 236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS-SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKITKTCEPCHKDCHSRSITRL 1990
NC V GN+ I +++ N L FL I+E+TG + + + +PL NLR+IRG + ++ AL D + + + LR+L I++G +Y+ ++F + W +++ P V + +C K CM G CWGP CQ +K C RC+ S D CC+ +C GGCT + C +C D+ C +CP I N E N + + C+NKCP + + C C K E + + C PC +C ++C S + ++D + K NCT G + + L +R I+G +++++ P + LS SNL I V SL I+ ++ L +SLK I ++ +N LCY+ + ++ +T N T I +N P+ C G VC C S GCWGPG N C+SC G C +C + G + VC+ C +C K TC G D C C + + CV +C F+ K + C C ++T L
Sbjct: 63 NCEVVMGNLEITSIEPGRN-----LSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG---IKLYEDRYALAIFLNYRKDGNYGLRE-----LGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMSSNAECGRCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQSAQ----TVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECFFSCVVGTLTPL 631
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 265.388 bits (677), Expect = 1.034e-71 Identity = 154/481 (32.02%), Postives = 243/481 (50.52%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK------VRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
SQC D ++ CT+C + CV CP+ F ADE +CHPCHP C +GC + C+ + LP++ L + S I V + L+ + RK +K+ L+ + + E + + + PN L ++ L+ I +ILG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GVS + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 532 SQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDK----ECHPCHPNCTDGCNNPTSHDCLWNDPLTLPQHARTPLIA-----------ASVIGGLFIIVIMALT------------------------FAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 957 HSP 2 Score: 189.889 bits (481), Expect = 4.736e-48 Identity = 163/597 (27.30%), Postives = 248/597 (41.54%), Query Frame = 2
Query: 236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS-SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKIT---KTCEPCHKDC 1966
NC V GN+ I +++ N L FL I+E+TG + + + +PL NLR+IRG + ++ AL D + + + LR+L I++G +Y+ ++F + W +++ P V +C K CM G CWGP CQ +K C RC+ S D CC+ +C GGCT + C +C D+ C +CP I N E N + + C+NKCP + + C C K E + + C PC +C ++C S S ++D + K NCT G + + L +R I+G +++++ P + LS SNL I V SL I+ ++ L +SLK I ++ +N LCY+ + ++ +T N T I +N P+ C G VC C S GCWGPG N C+SC G C +C + G + VC+ C +C K TC G D C C + + CV +C F+ K K C PCH +C
Sbjct: 37 NCEVVMGNLEITSIEPGRN-----LSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG---IKLYEDRYALAIFLNYRKDGNYGLRE-----LGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMSSG----RCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQ----SAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNC 596
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 265.003 bits (676), Expect = 1.044e-71 Identity = 154/481 (32.02%), Postives = 243/481 (50.52%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK------VRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
SQC D ++ CT+C + CV CP+ F ADE +CHPCHP C +GC + C+ + LP++ L + S I V + L+ + RK +K+ L+ + + E + + + PN L ++ L+ I +ILG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GVS + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 527 SQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDK----ECHPCHPNCTDGCNNPTSHDCLWNDPLTLPQHARTPLIA-----------ASVIGGLFIIVIMALT------------------------FAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 952 HSP 2 Score: 189.889 bits (481), Expect = 5.163e-48 Identity = 163/597 (27.30%), Postives = 248/597 (41.54%), Query Frame = 2
Query: 236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS-SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKIT---KTCEPCHKDC 1966
NC V GN+ I +++ N L FL I+E+TG + + + +PL NLR+IRG + ++ AL D + + + LR+L I++G +Y+ ++F + W +++ P V +C K CM G CWGP CQ +K C RC+ S D CC+ +C GGCT + C +C D+ C +CP I N E N + + C+NKCP + + C C K E + + C PC +C ++C S S ++D + K NCT G + + L +R I+G +++++ P + LS SNL I V SL I+ ++ L +SLK I ++ +N LCY+ + ++ +T N T I +N P+ C G VC C S GCWGPG N C+SC G C +C + G + VC+ C +C K TC G D C C + + CV +C F+ K K C PCH +C
Sbjct: 32 NCEVVMGNLEITSIEPGRN-----LSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG---IKLYEDRYALAIFLNYRKDGNYGLRE-----LGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMSSG----RCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQ----SAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNC 591
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234]) HSP 1 Score: 265.003 bits (676), Expect = 1.296e-71 Identity = 154/481 (32.02%), Postives = 243/481 (50.52%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK------VRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
SQC D ++ CT+C + CV CP+ F ADE +CHPCHP C +GC + C+ + LP++ L + S I V + L+ + RK +K+ L+ + + E + + + PN L ++ L+ I +ILG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GVS + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 531 SQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDK----ECHPCHPNCTDGCNNPTSHDCLWNDPLTLPQHARTPLIA-----------ASVIGGLFIIVIMALT------------------------FAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 956 HSP 2 Score: 189.119 bits (479), Expect = 8.841e-48 Identity = 162/597 (27.14%), Postives = 248/597 (41.54%), Query Frame = 2
Query: 236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS-SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKIT---KTCEPCHKDC 1966
NC V GN+ I +++ N L FL I+E+TG + + + +PL NLR+IRG + ++ AL D + + + LR+L I++G +Y+ ++F + W +++ P V +C K CM G CWGP CQ +K C RC+ S D CC+ +C GGCT + C +C D+ C +CP I N E N + + C+NKCP + + C C K E + + C PC +C ++C S + ++D + K NCT G + + L +R I+G +++++ P + LS SNL I V SL I+ ++ L +SLK I ++ +N LCY+ + ++ +T N T I +N P+ C G VC C S GCWGPG N C+SC G C +C + G + VC+ C +C K TC G D C C + + CV +C F+ K K C PCH +C
Sbjct: 36 NCEVVMGNLEITSIEPGRN-----LSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG---IKLYEDRYALAIFLNYRKDGNYGLRE-----LGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMSSG----RCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQSAQ----TVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNC 595
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771]) HSP 1 Score: 259.225 bits (661), Expect = 7.266e-70 Identity = 151/489 (30.88%), Postives = 244/489 (49.90%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C + SQC D ++ CT+C + CV CP F AD+ +CHPCHP C GC G + CI+ + LP++ L + + + V ++ + + RK +K+ L+ + + E + + + PN L ++ L+ + ++LG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 552 CVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-------------AGVIGGLFILVIMA----------------------LTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985 HSP 2 Score: 196.438 bits (498), Expect = 3.210e-50 Identity = 163/597 (27.30%), Postives = 260/597 (43.55%), Query Frame = 2
Query: 236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
NC V GN+ I +++ DL FL I+E+TG + + + +PL NLR+IRG ++LY + AL D + + + L++L I++G +Y+ ++F + W +++ +P ++T T + C + K +G CWGP + CQ ++ C RC+ D CC+ +C GGC+ + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + + C PC +C + C S S ++D + K NCT G + + + + L +R I+G +++++ P + S SNL I V SL I+ I+ L +SLK I I+ +N+ LCY+ + + T+N +I DN A+ C G VC+ C S GCWGPGP+ C+SC G IC E+C + G ++ S +C++C +C K TC G D C C H + CV +C F+ K + C PCH +C
Sbjct: 55 NCEVVMGNLEITSIEHNR-----DLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRRAEN--CTAEGMVCNHLC-SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGS-ICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNC 621
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771]) HSP 1 Score: 259.225 bits (661), Expect = 7.562e-70 Identity = 151/489 (30.88%), Postives = 244/489 (49.90%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C + SQC D ++ CT+C + CV CP F AD+ +CHPCHP C GC G + CI+ + LP++ L + + + V ++ + + RK +K+ L+ + + E + + + PN L ++ L+ + ++LG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 552 CVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-------------AGVIGGLFILVIMA----------------------LTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985 HSP 2 Score: 196.823 bits (499), Expect = 2.418e-50 Identity = 163/597 (27.30%), Postives = 260/597 (43.55%), Query Frame = 2
Query: 236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
NC V GN+ I +++ DL FL I+E+TG + + + +PL NLR+IRG ++LY + AL D + + + L++L I++G +Y+ ++F + W +++ +P ++T T + C + K +G CWGP + CQ ++ C RC+ D CC+ +C GGC+ + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + + C PC +C + C S S ++D + K NCT G + + + + L +R I+G +++++ P + S SNL I V SL I+ I+ L +SLK I I+ +N+ LCY+ + + T+N +I DN A+ C G VC+ C S GCWGPGP+ C+SC G IC E+C + G ++ S +C++C +C K TC G D C C H + CV +C F+ K + C PCH +C
Sbjct: 55 NCEVVMGNLEITSIEHNR-----DLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRRAEN--CTAEGMVCNHLC-SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGS-ICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNC 621
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Egfr (epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294]) HSP 1 Score: 247.284 bits (630), Expect = 3.557e-66 Identity = 158/552 (28.62%), Postives = 268/552 (48.55%), Query Frame = 2
Query: 2270 KGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHP-CHPQCNG--CYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN---------YKETSGNSNENICVF---------------VFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYT-----TNTFNNYIEIKQHEDEI---SYHAPH-----SPNQNRVRVIGNMRPRGNQKSI 3790
+ C C+ +CV C + + NS +CHP C PQ C G ++CI C ++ + CV++CP+ +K N+ ++C V+ SG ++ + +V + + + + R+ ++ L+ + TPS PN HL ++ + I ++LG G FG+VY G W + + K+ V IK L + E +DE +MASV + H RL+G+ + +L I+ MP G + Y+ ++K ++ + LL W QIA GM YLE+ ++HRDLA RNVL+ HV+ITDFGL+K++ + E GG VP++W+A+E++ IY+H++DVW+Y VT+WE+ TF + PY+ + A +I + KG RL QP IC++D+Y++M+KCW +D + RP F L EF + + + YL E+ + +N + ++ + ED + Y P SP+ +R ++ ++ N ++
Sbjct: 521 RDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY-------IDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKI---KVLGSGAFGTVYKGLW------------IPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQL-ITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSATSNNSTV 1049 HSP 2 Score: 197.593 bits (501), Expect = 1.406e-50 Identity = 162/574 (28.22%), Postives = 265/574 (46.17%), Query Frame = 2
Query: 221 QDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQ-FCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK-----TCSGLRSDQCIGGCKHAMENSMCVREC 1906
Q + NNC V GN+ I V+ DL FL I+E+ G + I + + +PL NL++IRG++ LY +N++ ++I + + + + +R+L+ I+ G + S+ ++ ++W +++++ +++ P+ C K C +G CWG CQ +K + C++RC D CC++QC GCT S C+ CQ D C+ CPP + N T + N + F C+ KCP ++ G C C YE + D +C C C ++C I +FK + S++ +K CT G + I +F P + +L+ L+ ++ I+G ++ ++ P L NL+ I SL ++ +I+ LGL+SLK I + + N LCY + +K + T N T I +N K C+ +VC+ C S+ GCWGP P C+SC NV G C E C + G S+ C++CH EC TC+G D CI C H ++ CV+ C
Sbjct: 52 QRMYNNCEVVLGNLEITYVQRNY-----DLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNA-LY--------ENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPK-CDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSD--CCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGI---GEFKDT-LSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITG--FLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTP--NQKTKIMNNRAE--KDCKAVNHVCNPLCSSE-GCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSE-CIQCHPECLPQAMNITCTGRGPDNCI-QCAHYIDGPHCVKTC 595
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:95410]) HSP 1 Score: 236.884 bits (603), Expect = 7.520e-63 Identity = 151/494 (30.57%), Postives = 241/494 (48.79%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNG------CYGVDKNHCIHCNNF------------------------KLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAY-----FSNANESDSQTPSP--PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVL--NHSCDQN-EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN 3637
C C + +CV C +V L + C PCHP+C CYG + + C C ++ K P+ E + + CP N + + +E C E + + V+ L +I + KR+R K++ Y + TPS PN + ++ L + ++LG G FG+VY G W D ++ K+ V IKVL N S N E +DE +MA V + RL+G+ + +L ++ MP G + ++ +++ L + LL W QIA GM YLE ++HRDLA RNVL+ NHV+ITDFGL+++++ ++ E GG VP++W+A+E++ ++H++DVW+Y VT+WE+ TF PY+ + A EI D + KG RL QP IC++D+Y++M+KCW +D E RP F L +EF + + + ++ N
Sbjct: 529 CVNCSQFLRGQECVEEC-RVWKGLPREYVRGK--HCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGI-----CQPCPINCTHSCVDLDERGCP------AEQRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKL---KVLGSGAFGTVYKGIWIPDG------------ENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL-VTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN 992 HSP 2 Score: 162.925 bits (411), Expect = 8.623e-40 Identity = 155/594 (26.09%), Postives = 246/594 (41.41%), Query Frame = 2
Query: 182 LDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTV--IDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETG-DEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQE-GECKTQCTFRKYERQGD----QCVPCKILCEQIC---TLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES-LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVREC 1906
L S ++ + L+ L C V GN+ + + + ++ L FL I+E+ G + I ++ + VPL+ LR++RG ++ L N + + + + + + LRSL I+ G + I + Q C V W ++L + + T + C C K CWG CQI + +C + C + +CC+ QC GCT S C+AC + +C+ CP N +T N R F C+ CP L E G C C E + +C C C +C +E + ++ +++ A C G + ESF + V + L+ E L I+G +YI P LS NL+ I ++ + SLT+ I LGL+SL+ + + NT LC+ + + + + N + +G + C G VC+ C ++ CWGPGP C++C+ G C E C V G L K CL CH EC ++TC G +DQC C H ++S CV C
Sbjct: 35 LPASPETHLDMLRH-LYQGCQVVQGNLELTYLPANAS-----LSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQ-DMVLWKDVLRKNNQLAPVDMDTNRSRAC-PPCAPTCKDNHCWGESPEDCQILTGT---ICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCYGLGMEHLRGAR-------AITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISA--WPESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFR----NPHQALLHSGNRPEEACGLEGLVCNSLC-ARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKG-LPREYVRGKHCLPCHPECQPQNSSETCYGSEADQC-EACAHYKDSSSCVARC 601
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Erbb3 (erb-b2 receptor tyrosine kinase 3 [Source:MGI Symbol;Acc:MGI:95411]) HSP 1 Score: 223.016 bits (567), Expect = 2.387e-58 Identity = 101/277 (36.46%), Postives = 167/277 (60.29%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFM---DEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
++LG G FG+V+ G W + + K+ V IKV+ + F D + + S+ H H +RL+G+ GS L++ Y+PLGS+ ++ +++++L ++LL W QIA GM YLE + ++HRDLA RNV++ + VQ+ DFG++ ++ P+ ++ P++W+A+E++ G Y+H++DVW+Y VT+WE+ TF PY L+ EI D + KG RL QP IC++D+Y++M+KCW +D RP F+ L EF + + YL
Sbjct: 711 KVLGSGVFGTVHKGIW------------IPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYL 974 HSP 2 Score: 199.519 bits (506), Expect = 4.431e-51 Identity = 169/621 (27.21%), Postives = 264/621 (42.51%), Query Frame = 2
Query: 182 LDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSVT----GKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAI--ESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNK--------ITKTCEPCHKDC 1966
+ G + Y TL + L C V GN+ I G DL FL I+E+TG + + + S +PL NLRV+RG +D A+ V ++ + + S++++ + L I+ G +YI + + C + ++W +++ P + V G C P C + C G CWGP CQI +K C + C RCF +CC+ +C GGC+ + C AC+ D+ C P CP + N+ T EPN + + + +C+ CP + + C C K E + C PC+ LC + C S Y ++D + NCT G + +P + + L +R I+G Y++++ P + + S SNL I SL + L + N +++ LG +SLK I ++ N +LCY + +++ + I + + + C G VC C S GCWGPGP C+SC N +C +C V G + C CH EC TC+G SD C C H + CV C K C PCH++C
Sbjct: 38 VTGDADNQYQTLYK-LYEKCEVVMGNLEI-----VLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQ---VYDGKFAI----FVMLNYNTNSSHALRQ-LRFTQLTEILLGGVYIEKNDKLCH-MDTIDWRDIVRVPDAEIVVKNNGGNCPP----CHEVC-----KGRCWGPGPEDCQILTKTICAPQ-CNGRCF--GPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEGTGSGS------RYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITG--YLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGE---CVAEGKVCDPLCSSG-GCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAH-CFSCHPECQPMEGTSTCNGSGSDAC-ARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENC 617
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|P04412|EGFR_DROME (Epidermal growth factor receptor OS=Drosophila melanogaster OX=7227 GN=Egfr PE=1 SV=3) HSP 1 Score: 476.478 bits (1225), Expect = 4.575e-143 Identity = 352/1217 (28.92%), Postives = 569/1217 (46.75%), Query Frame = 2
Query: 140 EYPEIKYCFSSMDLLD--GSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQD---ISVSNSIKTVIDLRSLRSIVSGNIYISSQF-CSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHR---------PEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES--LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-DSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCY--QNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADE-TNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKL-PENE-----NLTLFSCVESCP-----SNYKETSGN--------------SNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLAR-KGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYP 3634
E+ + K C + L ++ +Y L+ D NCT+V GN+ + + +E+ DL FL I+E+TG + I + ++ V L++IRG + F +S++++ + V+ S +++ LR +++G + + + + ++W+E++ + T T +C K C + G CWG CQ FSK C + RC+ + ECC+ C GGCT CIAC+ D V + ECPP + N T + E N + + C+ +CP LL G C C K ++ G +CVPC C + C + + + NCT G ++I ++F + P +P+ + + + ++ I+G Y++++ + +LS+ NL+ I L+ + +L I+ + + L +++LK I + ++ ++N LCY ++ I K +++N AD LCE+ G +CS QC+ GCWG G + C++C N C +C GY++N ++ C CH EC +TC+G +D C C H + CV EC + + ++ C CH C CTGP +T G G C C I+ D V+RC + +GYF + + CH LC CT + C++C Y ++C + CP AD T+ +C HP+CNGC G + C C NFKL NE N T+F+C CP NY+ T+ +N ++ + ++G L + ++T C + K K++ K+ S +S+ PS N + + E GG +LG G FG VY G W + ++ K+ V IK L S EF+ E IMAS H + L+L+ V S+ +LI+ MPLG + Y+ N+ + K LL W+ QIA GM YLE ++HRDLA RNVL+ + V+ITDFGL+K+++ + +E + GG +P++WLA+E +R+ +++ K+DVWA+ VT+WE+ TF P+E + A +I D I G +L QP+ICSLDIY +L CW +D RP F+ L T F ++ + YL+ P
Sbjct: 95 EFVKGKICIGTKSRLSVPSNKEHHYRNLR-DRYTNCTYVDGNLKLTWLPNENL----DLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRG-------------RTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPK-CHESCTHG-CWGEGPKNCQKFSKLTCSPQCAGGRCYGPKP--RECCHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDK-GGECVPCNGPCPKTCPGVTVLHAGN------------IDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPL-DPERREVFSTVKEITG--YLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEP--EQKVWVNENLRAD--LCEKNGTICSDQCNED-GCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAYKFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKYNDR--GVCRECHATCDG--------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGR-----AVCRKCHPLCELCTNYGYHE--------QVCSKCTHYKRREQCETECP-------ADHYTDEEQRECFQRHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITG----------AVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGG-VLGMGAFGRVYKGVWVPEG------------ENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMS-SQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIP 1208
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|P0CY46|EGFR_APIME (Epidermal growth factor receptor OS=Apis mellifera OX=7460 GN=Egfr PE=2 SV=1) HSP 1 Score: 466.463 bits (1199), Expect = 1.811e-140 Identity = 335/1047 (32.00%), Postives = 499/1047 (47.66%), Query Frame = 2
Query: 581 LANVEWNELLEDPTRQ--------SVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICT-LEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTE-SFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAI--ESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQ--NTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENE----NLTLFSCVESCPSNYKETSGNSN-ENICVFV---FLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSP----PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLS 3628
+ + W E++ P+ S CTP C K C Q CWG CQ +SK C + RCF ECC+ C GGCT S CIAC+ D+ VC ECPP + N T EPN + + C+ +CPE LL+ G C C +K G +CVPC C + C +E++ S N + ++ + L +F+GF + SF K ++ P D L+ L+ I+G + I FK +LS+ NL+ I +L + SL ++ T + GL SLK I + +I N LCY + I K+ +++S+N + C + G VC QC + GCWGPGP C+SC N LG C ++C PG + T KV CH+EC +C G +D C CKHA + CV EC + + + C+ CH +C + C GP N GP GC+ C IL D+ E C Q + +GY+ P K + CH C +CT C +C Y ++C CP AD + C PC +C GC+G N C C N+K+ +E N T F+C E+C Y N + E C + ++ V + F + I + + K K + +K + D++ P PN+ L +I + + G ILG G FG+VY G W + ++ K+ V IKVL+ N EF+DE IMASV H + L+L+ V S+ +L++ MPLG + ++ + K + K LL W QIA GM YLE ++HRDLA RNVL+ N V+ITDFGL+K+++ N+++ + GG +P++WLA+E ++ +++HK+DVWA+ VT+WE+ T+ PYE + A + + + KG RL QP IC++D+Y++M+KCW +D E RP+F+ L +F S + YL+
Sbjct: 10 IRTINWEEIITGPSAMYSYVYNFTSPERACTP----CDKSCEQG-----CWGEGPENCQKYSKTNCSPQCWQGRCF--GPNPRECCHLFCAGGCTGPKQSDCIACKNFFDDGVCTQECPPMQKYNPTTYSWEPNPDGKYAYGATCVRRCPEHLLKDNGACVRSCPPKKKALNG-ECVPCDGPCPKTCKGVEKVHSGNIDSFKDCTIIEGSITILDQ--SFQGFQHVYRNFSFGKRYEKMHP----DKLEVFSTLKEITGFLNIQGDHKDFK--NLSYFRNLEVIGGRTLTEYFA-SLYVVKTSLVSFGLSSLKKIYSGSIAILENKNLCYAQSINWTRIKKSSEHE--SLLSNN--RNESECIKDGLVCDEQCSDE-GCWGPGPAQCLSCKNFILGNDCLQDCTA-PGIYQADEKTCKV---CHEECDGSCIGPNTDHC-KKCKHARDGPFCVPECPASKYND--NGVCKSCHGNC-------VGGCEGPENNIGPNGCHSCDKAIL-NDHVPEGCLQKKESCPDGYYYEWVSPLEQGPLKPLASK-----AVCRKCHSRCKKCTGYGFHE--------HVCQECTKYKRGEQCEDECP-------ADYFADANKLCIPCFSECRGCFGPGPNQCYKCRNYKIYIDEDTDGNTTSFNCTETCTPEYPHKIFNPDSEPYCSLETAGLIENELQPAILAGVAVFALAFLVVAAIIMYFWRVRAKAKENTVKMTMALTGLDDNEPLRPTGVKPNLAKLRIIKEEEMR---KGGILGYGAFGNVYKGVWVPEG------------ENVKIPVAIKVLHDGTGANTSKEFLDEAYIMASVEHPNLLQLLAVCMT-SQMMLVTQLMPLGCLLDFVRRFKDKIGSKALLNWCTQIARGMAYLEERRLVHRDLAARNVLVQTPNCVKITDFGLAKLLDINEEQYKAAGGKMPIKWLALECIQHRVFTHKSDVWAFGVTIWEVLTYGGRPYENVPARNVPELLEKGERLPQPAICTIDVYMIMIKCWMLDAESRPSFKELAEDFAKMSRDPGRYLA 979 HSP 2 Score: 61.2326 bits (147), Expect = 7.769e-8 Identity = 64/247 (25.91%), Postives = 99/247 (40.08%), Query Frame = 2
Query: 245 HVYGNIFINNVKSESNGSEPD-LEFLSGIKEITGSLKIRNS-----NISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSV------TGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCF-------LSETGDEEC--CNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKK 916
HVY N + + PD LE S +KEITG L I+ N+S RNL VI G + S+ ++ S L SL+ I SG+I I + C + ++ W + + +S+ +C C ++C +G CWGP +QC C+ + N C + + ++ C C+ +C G C ++ C C+ D C PECP K
Sbjct: 220 HVYRNFSFGKRYEKMH---PDKLEVFSTLKEITGFLNIQGDHKDFKNLSY--FRNLEVIGGRTLTEYFASLYVVKTSL---------------VSFGLSSLKKIYSGSIAILENKNLCYA-QSINWTRIKKSSEHESLLSNNRNESECIKDGLVCDEQCSDEG----CWGPGPAQCL---SCKNFILGNDCLQDCTAPGIYQADEKTCKVCHEECDGSCIGPNTDHCKKCKHARDGPFCVPECPASK 438
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|P24348|LET23_CAEEL (Receptor tyrosine-protein kinase let-23 OS=Caenorhabditis elegans OX=6239 GN=let-23 PE=1 SV=3) HSP 1 Score: 407.142 bits (1045), Expect = 6.956e-119 Identity = 393/1388 (28.31%), Postives = 610/1388 (43.95%), Query Frame = 2
Query: 86 LHILLISLIFYRYSDSLIEYPEIKYCFSSMDLL-----DGSQSSNYNTLKQDLGN---NCTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDK-----CVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
L I+ I L F+ S++ + K C S D L +G + +DL C VYGN+ I +++ ES S D + F ++EI GSL I +NI + LRVI GD HD+ AL I ++ + V+ +R LR I +G++ I + C ++W ELL DP Q V + T + C Q GKS CWG + CQ ++ + C+ +CF S T ECC+S CLGGCT +CIAC + +C CP +KI N +TG N R N C+ +CP LL + C C+ Y+ D +C C+ C +ICT++ L LK L C QID ++H + LK LE ++ +S YI + F L FL NLQ IE + + +L I D+ L L SLK+IK A+ N +LCY + +I+ + ++ ++ D KLCE VC C+ + GCWG P C+ C + C E C + G+L N TS C +C EC +TC+GL C+ C+H N M CV +C +HF + CE CH C+ CTGP + G GGC +C+ + + + C Q++ +N + + +I + VI C +C+I S + + CK + C+ CP V +F+ D N+ KCH Q C C C NF + + + + CV CP N ++ + E C+ ++ + ++ + + F + + F L + +R K + + TP PNM+ + +I S L+ + + LG G FG+V+AG + K+ K+ V IKV Q +E ++E M +RH + L++IG +++ Y PLG+++ +L+ +K++L + + + QIA+GM YLE ++HRDLATRNVL+ K NHV+ITDFGLSKI+ + D + I G V ++WLAIE Y+H +DVWA+ VT WEI TF PY+ + I + + G RL QP CS D+Y +L+CW DP+ RP FE L+ FK + + +L N E+ + T F+ I+ + + D+ ++ PH NR++ + + R + P + + V ++ +N + SNG D++++P+ +PSS + Y EP
Sbjct: 11 LLIIPIFLTFFGNSNAQL----WKRCVSPQDCLCSGTTNGISRYGTGNILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1293
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|Q62956|ERBB4_RAT (Receptor tyrosine-protein kinase erbB-4 OS=Rattus norvegicus OX=10116 GN=Erbb4 PE=1 SV=3) HSP 1 Score: 264.618 bits (675), Expect = 9.407e-71 Identity = 154/489 (31.49%), Postives = 246/489 (50.31%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVR------TFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C + SQC D ++ CT+C + CV CP V F AD+ +CHPCHP C GC G + CI+ + LP++ L + + + V ++ + + RK +K+ L+ + + E + + + PN L ++ L+ + ++LG G FG+VY G W + + K+ V IK+LN + EFMDE IMASV H H +RL+GV + +L ++ MP G + +Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+YI+M+KCW +D + RP F+ L EF + + + YL
Sbjct: 552 CVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDVLQGANSFIFKYADQDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-------------AGVIGGLFILVIMA----------------------LTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYIVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985 HSP 2 Score: 196.052 bits (497), Expect = 3.664e-49 Identity = 163/597 (27.30%), Postives = 260/597 (43.55%), Query Frame = 2
Query: 236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
NC V GN+ I +++ DL FL I+E+TG + + + +PL NLR+IRG ++LY + AL D + + + L++L I++G +Y+ ++F + W +++ +P ++T T + C + K +G CWGP + CQ ++ C RC+ D CC+ +C GGC+ + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + + C PC +C + C S S ++D + K NCT G + + + + L +R I+G +++++ P + S SNL I V SL I+ I+ L +SLK I I+ +N+ LCY+ + + T+N +I DN A+ C G VC+ C S GCWGPGP+ C+SC G IC E+C + G ++ S +C++C +C K TC G D C C H + CV +C F+ K + C PCH +C
Sbjct: 55 NCEVVMGNLEITSIEHNR-----DLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTIGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITG--FLNIQTWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TVNQRIVIRDNRRAEN--CTAEGMVCNHLC-SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGS-ICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDVLQGANSFIFKYADQDRECHPCHPNC 621
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|Q61527|ERBB4_MOUSE (Receptor tyrosine-protein kinase erbB-4 OS=Mus musculus OX=10090 GN=Erbb4 PE=1 SV=5) HSP 1 Score: 259.225 bits (661), Expect = 5.082e-69 Identity = 151/489 (30.88%), Postives = 244/489 (49.90%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C + SQC D ++ CT+C + CV CP F AD+ +CHPCHP C GC G + CI+ + LP++ L + + + V ++ + + RK +K+ L+ + + E + + + PN L ++ L+ + ++LG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 552 CVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-------------AGVIGGLFILVIMA----------------------LTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985 HSP 2 Score: 196.438 bits (498), Expect = 2.245e-49 Identity = 163/597 (27.30%), Postives = 260/597 (43.55%), Query Frame = 2
Query: 236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
NC V GN+ I +++ DL FL I+E+TG + + + +PL NLR+IRG ++LY + AL D + + + L++L I++G +Y+ ++F + W +++ +P ++T T + C + K +G CWGP + CQ ++ C RC+ D CC+ +C GGC+ + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + + C PC +C + C S S ++D + K NCT G + + + + L +R I+G +++++ P + S SNL I V SL I+ I+ L +SLK I I+ +N+ LCY+ + + T+N +I DN A+ C G VC+ C S GCWGPGP+ C+SC G IC E+C + G ++ S +C++C +C K TC G D C C H + CV +C F+ K + C PCH +C
Sbjct: 55 NCEVVMGNLEITSIEHNR-----DLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRRAEN--CTAEGMVCNHLC-SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGS-ICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNC 621
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: A0A1B1ACY3 (Receptor protein-tyrosine kinase (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 2530.36 bits (6557), Expect = 0.000e+0 Identity = 1284/1292 (99.38%), Postives = 1284/1292 (99.38%), Query Frame = 2
Query: 131 SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLT FSCVESCPSNYKETSGNSNENICVFVFLSGLELILVILAVV FVL TLF IITKFC ARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI
Sbjct: 53 SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTSFSCVESCPSNYKETSGNSNENICVFVFLSGLELILVILAVVLFFVLCTLFTIITKFCHARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 1344
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: F6KBQ5 (Epidermal growth factor receptor 1 (Fragment) OS=Schmidtea mediterranea OX=79327 GN=egfr-1 PE=2 SV=1) HSP 1 Score: 825.469 bits (2131), Expect = 0.000e+0 Identity = 396/398 (99.50%), Postives = 397/398 (99.75%), Query Frame = 2
Query: 2813 GKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
GKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNS TYLSYPNVEQNYTTNTFNNYIEIKQHEDEIS+HAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI
Sbjct: 1 GKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSGTYLSYPNVEQNYTTNTFNNYIEIKQHEDEISHHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 398
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: A0A0X3PH98 (Receptor protein-tyrosine kinase OS=Schistocephalus solidus OX=70667 GN=TR102389 PE=4 SV=1) HSP 1 Score: 599.742 bits (1545), Expect = 0.000e+0 Identity = 413/1324 (31.19%), Postives = 632/1324 (47.73%), Query Frame = 2
Query: 77 WIYLHILL-ISLIFYRYSDSLIEYPEIKYCFSS----MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSV----------TGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKI-LCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP---IISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-------------------------------------------DSTSKV-----CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDC-HSRSITRLPV----CTGPSNTPGPGGCNKCQSMILRRDYQVER--CYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILE-----PCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLG----------KCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICV----FVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKF-----CLARKGKRK--RDKLKAYFSNANESDSQTPSP---PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ---------------------------------NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINP-NKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
+++L +LL +R+S + EYP IK C S LD + Y + + CTH+ GN+ + N++ NGS+PDL FL+ I E++G + I N+++ +PL +LR+IRG Y + +L NS V + + ++ V+DLR L I + N+ + + Q C V+++ L +P +Q C T C C+Q + +CWGP QCQ+ SKC + C + C+ C+GGCT SS+C AC+ L+N C CPPK I++ T E N F+ +IC+ CP L+ + C +C F+ C PC C + CT E+IF N + + +K+ C + G + ++ +F K P++ DDL L NLR I G +Y+D +P +L +L+FL NL + + + +L+I N +++ +LG KSL+ + A + LCY + K I+ T + P C+ G+VC +C GCWGPGP C C + G +C +CL +PG+ T P ++ S+V C +CH ECA+TC + CIG CKH E + CV CSR ++ ++ TK C CH C ++ T LPV C+GP + G GGC C +R++ + +R C ++ + + L+ PCH LC C T C +C+G+ + +CV CP T++ + N++L +C CH QC GCY C++C K+ +E F C +CP + T N+ N+C+ + +SG ++ L + + C K KR+ R+ LK+ ++N D ++ + PNM L +I+SD+L+F LG G FG+VY GKW++ + N + + +DV +KV+ + NE + E ++MASV H +CL LIGV + + ++S+++ LGS+++YL +NK SL LL WAEQIA+GM YLE IIHRDLA RNVL+ HVQITDFGL+K+++ +++ + + G VP+RWLAIETL+ GIYSHKTDVW+Y VTLWEIFTF PYE ++ +I+D ++KG RL QPDIC+LD Y++M+KCW D + RP F L F ++ YL
Sbjct: 7 YLFLALLLSTGGKSFRFSLT-PEYPNIKICRSRNVDCKTSLDPNIQLRYYRRQY---SECTHILGNLVLCNLRRYDNGSDPDLSFLTSIVEVSGYVYISNNDVRRIPLTSLRIIRGMVPYY----IPSLGNSALVISRNAFNKTVGLE-VLDLRKLTVIQNHNVALWDNPQLCYIAFRVDFHALFPNPKQQEALRVSNSDLISQSGCDFDNTSCHPSCVQTDTNAYCWGPEKDQCQLRSKCLHDT-SRYCLMDGYNLGTTCDDACIGGCTG-HSSNCWACRDKLNNRTCTGSCPPKYILSHVTSRQELNPEFKYDLHDICVKTCPAPFLKMDTVCVIECDFKTTIPINGSCEPCATSPCAEHCTKEQIFGTN-----FPLITSAAAEKMKTCEYYSGPIYLNRMAFEKRGSGPAPLARLDDLWNLRNLREIVGYIYLDFTGSPPELTNLTFLQNLYKVTAEFSDGVSLGIALSIYNASNLEFLGFKSLRYVDTDAYLEFLPS-LCY--LSGLKQILPMRT---------KAVKSPTTCDNEGHVCHSECLPITGCWGPGPAMCAHCCGFQAGDVCVSSCLDEPGFYTPPGLETQLVSVGASGSPFSSLQNAANIQCPTLPLTAAQLATMTAEEAISRVIPSPACARCHVECAQTCFNASNIACIGPCKHYKEANACVSNCSRNYYADETTKDCLLCHPTCSNALQSTPLPVSVAACSGPGSYLGNGGCTFCH--FIRKNPETQRFECLDRGCPPSHYGRPTHLSELKIAHVNLSPDNLHAATLDIRECAPCHPLCEVC--------EGPSTHETVCLKCRGWIYKGECVETCPSDDTYMPNE--NATLNEQELAALKAKQCLLCHRQCAGGCYAAGPEDCVNCRFRKILIDEESNKFVCNSTCPPDQPFTMPNT--NLCLDKIKYELISGAAATRTRNRILLGCSLGLFGVFLLALLIIVPCFHYKAKRRKIREALKSVYTNKAAPDMKSQAASREPNMGRLEIINSDDLQFDESSTPLGTGAFGAVYRGKWRVPKRIL---AEYNWPRSTNLDVAVKVIRSPAEPVRGTVSGKAATMEPSDTSPEAKVMERIAEKNNLNEMLSEAKVMASVSHLNCLPLIGVCLTKNMQCMVSAFVELGSIDRYLRENKDSLNSYTLLSWAEQIADGMAYLEARGIIHRDLAARNVLLQSPEHVQITDFGLAKMLDSLDENSVVVRSGRVPIRWLAIETLQFGIYSHKTDVWSYGVTLWEIFTFGKQPYENIETVDIKDHVMKGGRLTQPDICTLDAYMVMVKCWMEDYDSRPTFLELMRLFHDFCQTPGRYL 1285
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: A0A0X3Q4X9 (Receptor protein-tyrosine kinase OS=Schistocephalus solidus OX=70667 GN=TR102389 PE=4 SV=1) HSP 1 Score: 597.816 bits (1540), Expect = 0.000e+0 Identity = 413/1324 (31.19%), Postives = 631/1324 (47.66%), Query Frame = 2
Query: 77 WIYLHILL-ISLIFYRYSDSLIEYPEIKYCFSS----MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSV----------TGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKI-LCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP---IISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-------------------------------------------DSTSKV-----CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDC-HSRSITRLPV----CTGPSNTPGPGGCNKCQSMILRRDYQVER--CYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILE-----PCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLG----------KCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICV----FVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKF-----CLARKGKRK--RDKLKAYFSNANESDSQTPSP---PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ---------------------------------NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINP-NKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
+++L +LL +R+S + EYP IK C S LD + Y + + CTH+ GN+ + N++ NGS+PDL FL+ I E++G + I N+++ +PL +LR+IRG Y + +L NS V + + ++ V+DLR L I + N+ + + Q C V+++ L +P +Q C T C C+Q + +CWGP QCQ+ SKC + C + C+ C+GGCT SS+C AC+ L+N C CPPK I++ T E N F+ +IC+ CP L+ + C +C F+ C PC C + CT E+IF N + + +K+ C + G + ++ +F K P++ DDL L NLR I G +Y+D +P +L +L+FL NL + + + +L+I N +++ +LG KSL+ + A + LCY + K I+ T + P C+ G+VC +C GCWGPGP C C + G +C +CL +PG+ T P ++ S+V C +CH ECA+TC + CIG CKH E + CV CSR ++ ++ TK C CH C ++ T LPV C+GP + G GGC C +R++ + +R C ++ + + L+ PCH LC C T C +C+G+ + +CV CP T++ + N++L +C CH QC GCY C++C K+ +E F C +CP + T N+ N+C+ + +SG ++ L + + C K KR+ R+ LK+ ++N D ++ + PNM L +I+SD+L+F LG G FG+VY GKW+ + N + + +DV +KV+ + NE + E ++MASV H +CL LIGV + + ++S+++ LGS+++YL +NK SL LL WAEQIA+GM YLE IIHRDLA RNVL+ HVQITDFGL+K+++ +++ + + G VP+RWLAIETL+ GIYSHKTDVW+Y VTLWEIFTF PYE ++ +I+D ++KG RL QPDIC+LD Y++M+KCW D + RP F L F ++ YL
Sbjct: 7 YLFLALLLSTGGKSFRFSLT-PEYPNIKICRSRNVDCKTSLDPNIQLRYYRRQY---SECTHILGNLVLCNLRRYDNGSDPDLSFLTSIVEVSGYVYISNNDVRRIPLTSLRIIRGMVPYY----IPSLGNSALVISRNAFNKTVGLE-VLDLRKLTVIQNHNVALWDNPQLCYIAFRVDFHALFPNPKQQEALRVSNSDLISQSGCDFDNTSCHPSCVQTDTNAYCWGPEKDQCQLRSKCLHDT-SRYCLMDGYNLGTTCDDACIGGCTG-HSSNCWACRDKLNNRTCTGSCPPKYILSHVTSRQELNPEFKYDLHDICVKTCPAPFLKMDTVCVIECDFKTTIPINGSCEPCATSPCAEHCTKEQIFGTN-----FPLITSAAAEKMKTCEYYSGPIYLNRMAFEKRGSGPAPLARLDDLWNLRNLREIVGYIYLDFTGSPPELTNLTFLQNLYKVTAEFSDGVSLGIALSIYNASNLEFLGFKSLRYVDTDAYLEFLPS-LCY--LSGLKQILPMRT---------KAVKSPTTCDNEGHVCHSECLPITGCWGPGPAMCAHCCGFQAGDVCVSSCLDEPGFYTPPGLETQLVSVGASGSPFSSLQNAANIQCPTLPLTAAQLATMTAEEAISRVIPSPACARCHVECAQTCFNASNIACIGPCKHYKEANACVSNCSRNYYADETTKDCLLCHPTCSNALQSTPLPVSVAACSGPGSYLGNGGCTFCH--FIRKNPETQRFECLDRGCPPSHYGRPTHLSELKIAHVNLSPDNLHAATLDIRECAPCHPLCEVC--------EGPSTHETVCLKCRGWIYKGECVETCPSDDTYMPNE--NATLNEQELAALKAKQCLLCHRQCAGGCYAAGPEDCVNCRFRKILIDEESNKFVCNSTCPPDQPFTMPNT--NLCLDKIKYELISGAAATRTRNRILLGCSLGLFGVFLLALLIIVPCFHYKAKRRKIREALKSVYTNKAAPDMKSQAASREPNMGRLEIINSDDLQFDESSTPLGTGAFGAVYRGKWRGPKRIL---AEYNWPRSTNLDVAVKVIRSPAEPVRGTVSGKAATMEPSDTSPEAKVMERIAEKNNLNEMLSEAKVMASVSHLNCLPLIGVCLTKNMQCMVSAFVELGSIDRYLRENKDSLNSYTLLSWAEQIADGMAYLEARGIIHRDLAARNVLLQSPEHVQITDFGLAKMLDSLDENSVVVRSGRVPIRWLAIETLQFGIYSHKTDVWSYGVTLWEIFTFGKQPYENIETVDIKDHVMKGGRLTQPDICTLDAYMVMVKCWMEDYDSRPTFLELMRLFHDFCQTPGRYL 1285
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: A0A0X3P0D0 (Receptor protein-tyrosine kinase OS=Schistocephalus solidus OX=70667 GN=TR102389 PE=4 SV=1) HSP 1 Score: 593.193 bits (1528), Expect = 0.000e+0 Identity = 413/1334 (30.96%), Postives = 633/1334 (47.45%), Query Frame = 2
Query: 77 WIYLHILL-ISLIFYRYSDSLIEYPEIKYCFSS----MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQ--------------------SVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKI-LCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP---IISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-------------------------------------------DSTSKV-----CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDC-HSRSITRLPV----CTGPSNTPGPGGCNKCQSMILRRDYQVER--CYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILE-----PCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLG----------KCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICV----FVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKF-----CLARKGKRK--RDKLKAYFSNANESDSQTPSP---PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ---------------------------------NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINP-NKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
+++L +LL +R+S + EYP IK C S LD + Y + + CTH+ GN+ + N++ NGS+PDL FL+ I E++G + I N+++ +PL +LR+IRG Y + +L NS V + + ++ V+DLR L I + N+ + + Q C V+++ L +P +Q S + T C C+Q + +CWGP QCQ+ SKC + C + C+ C+GGCT SS+C AC+ L+N C CPPK I++ T E N F+ +IC+ CP L+ + C +C F+ C PC C + CT E+IF N + + +K+ C + G + ++ +F K P++ DDL L NLR I G +Y+D +P +L +L+FL NL + + + +L+I N +++ +LG KSL+ + A + LCY + K I+ T + P C+ G+VC +C GCWGPGP C C + G +C +CL +PG+ T P ++ S+V C +CH ECA+TC + CIG CKH E + CV CSR ++ ++ TK C CH C ++ T LPV C+GP + G GGC C +R++ + +R C ++ + + L+ PCH LC C T C +C+G+ + +CV CP T++ + N++L +C CH QC GCY C++C K+ +E F C +CP + T N+ N+C+ + +SG ++ L + + C K KR+ R+ LK+ ++N D ++ + PNM L +I+SD+L+F LG G FG+VY GKW++ + N + + +DV +KV+ + NE + E ++MASV H +CL LIGV + + ++S+++ LGS+++YL +NK SL LL WAEQIA+GM YLE IIHRDLA RNVL+ HVQITDFGL+K+++ +++ + + G VP+RWLAIETL+ GIYSHKTDVW+Y VTLWEIFTF PYE ++ +I+D ++KG RL QPDIC+LD Y++M+KCW D + RP F L F ++ YL
Sbjct: 7 YLFLALLLSTGGKSFRFSLT-PEYPNIKICRSRNVDCKTSLDPNIQLRYYRRQY---SECTHILGNLVLCNLRRYDNGSDPDLSFLTSIVEVSGYVYISNNDVRRIPLTSLRIIRGMVPYY----IPSLGNSALVISRNAFNKTVGLE-VLDLRKLTVIQNHNVALWDNPQLCYIAFRVDFHALFPNPKQQEALRVSNSDLISQSGCDFGSSQSHTNLANNTSCHPSCVQTDTNAYCWGPEKDQCQLRSKCLHDT-SRYCLMDGYNLGTTCDDACIGGCTG-HSSNCWACRDKLNNRTCTGSCPPKYILSHVTSRQELNPEFKYDLHDICVKTCPAPFLKMDTVCVIECDFKTTIPINGSCEPCATSPCAEHCTKEQIFGTN-----FPLITSAAAEKMKTCEYYSGPIYLNRMAFEKRGSGPAPLARLDDLWNLRNLREIVGYIYLDFTGSPPELTNLTFLQNLYKVTAEFSDGVSLGIALSIYNASNLEFLGFKSLRYVDTDAYLEFLPS-LCY--LSGLKQILPMRT---------KAVKSPTTCDNEGHVCHSECLPITGCWGPGPAMCAHCCGFQAGDVCVSSCLDEPGFYTPPGLETQLVSVGASGSPFSSLQNAANIQCPTLPLTAAQLATMTAEEAISRVIPSPACARCHVECAQTCFNASNIACIGPCKHYKEANACVSNCSRNYYADETTKDCLLCHPTCSNALQSTPLPVSVAACSGPGSYLGNGGCTFCH--FIRKNPETQRFECLDRGCPPSHYGRPTHLSELKIAHVNLSPDNLHAATLDIRECAPCHPLCEVC--------EGPSTHETVCLKCRGWIYKGECVETCPSDDTYMPNE--NATLNEQELAALKAKQCLLCHRQCAGGCYAAGPEDCVNCRFRKILIDEESNKFVCNSTCPPDQPFTMPNT--NLCLDKIKYELISGAAATRTRNRILLGCSLGLFGVFLLALLIIVPCFHYKAKRRKIREALKSVYTNKAAPDMKSQAASREPNMGRLEIINSDDLQFDESSTPLGTGAFGAVYRGKWRVPKRIL---AEYNWPRSTNLDVAVKVIRSPAEPVRGTVSGKAATMEPSDTSPEAKVMERIAEKNNLNEMLSEAKVMASVSHLNCLPLIGVCLTKNMQCMVSAFVELGSIDRYLRENKDSLNSYTLLSWAEQIADGMAYLEARGIIHRDLAARNVLLQSPEHVQITDFGLAKMLDSLDENSVVVRSGRVPIRWLAIETLQFGIYSHKTDVWSYGVTLWEIFTFGKQPYENIETVDIKDHVMKGGRLTQPDICTLDAYMVMVKCWMEDYDSRPTFLELMRLFHDFCQTPGRYL 1295
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629]) HSP 1 Score: 264.233 bits (674), Expect = 5.472e-72 Identity = 164/552 (29.71%), Postives = 265/552 (48.01%), Query Frame = 2
Query: 2246 ISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKAD---ETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL--------SYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPH-----SPNQNRVRVIGNMRPRGNQKSII---VPEHVQRFLNG 3826
++ SK GC +C + CV+ CP+ K + S+ C CH C GC G + C F S + I FV LS + + R+ +++ L+ + TPS PN + L ++ + I ++LG G FG+VY G W + +D K+ V IKVL + E +DE +MASV H H RL+G+ + +L +S MP G + Y+++NK ++ + LL W QIA GM YLE+ H++HRDLA RNVL+ HV+ITDFGL+K+++ ++ E GG VP++W+A+E++ Y+H++DVW+Y VT+WE+ TF T PY+ + A EI + KG RL QP IC++D+Y++M+KCW +D E RP F L EF + + YL P+ + + + +++ + D Y P+ SP+ +R +++ ++ ++S++ +P+ RFL+G
Sbjct: 511 LTCSKPGPDGCVECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQGCTGPELKDCREYKPF------------------SGMSVIAAGVVGGILAFVILS----------------------LGVAVLVRRRHIKRKRTLRRLLQERELVEPLTPSGEAPNQSLLRILKETEFKKI---KVLGSGAFGTVYKGLWVPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTSTVQL-VSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADEKEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVIQGDERMHLPSPTDSKFYRSLMSGVDLDESMDADEYLMPNHGFFSSPSTSRTQLLHSVNLFPVRESLMLRYIPDPTDRFLDG 1006 HSP 2 Score: 157.147 bits (396), Expect = 3.250e-38 Identity = 163/632 (25.79%), Postives = 246/632 (38.92%), Query Frame = 2
Query: 173 MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKIT---------KTCEPCHKDCHSRSITRLPVCTGP 2008
M LL N +K + +NCT + + N++ E DL FL I+E+ G + I + +PL NLR I+ G+ + L+N ++ L + S+TGK C C +G CW P + CQ F+K C+ RC + D CCN C GCT + C+AC+ D+N C+ CPP + N T PN + F C+ CP ++ G C C+ YE D +C C+ LC ++C+ + + S++ + NCTT G V I + P + L ++ I+GS+ + P + SLS NL+ I T SL I I++LGL++L+ I + + N KLCY + +K + +++ + V N ADP C C C + GCWGPGP C SC + C C + G + + CL+C EC + TCS D C+ C H + CV C + K T + C+ CH++C CTGP
Sbjct: 27 MTLLSTVDEHYQNMVK--MYSNCT-----VILENLEITYTSHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLR----------------------------------------------IIRGHTLYDGLALAVLSNYNNSKGLRELPLISLTGK------MCHSDCY----NGSCWAPGRANCQTFTKLTCAEQCSGRCKGPKPSD--CCNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGKYNFGATCVKNCPHNYVVTDHGACVRSCSPGTYEVDEDGVRKCKKCEGLCPKVCSGLGVGN----LVGVMSINSSNIDSFENCTTINGDVLILKTTLNGDTFTKTPKMDPAKLNVFRTVKEITGSLLVQY--WPKNMPSLSPFENLEVIRGRTKHQGTVSLGIGKLPITHLGLRALREISDGDVSISANAKLCYNSPEHWKRLFRSE--DQVARPMQN--ADPATCAALNQTCDEMCTPE-GCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECE-VNMTCLECDPECRPLNGSLTCSKPGPDGCV-ECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQG-------CTGP 573
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629]) HSP 1 Score: 260.381 bits (664), Expect = 1.661e-70 Identity = 167/566 (29.51%), Postives = 264/566 (46.64%), Query Frame = 2
Query: 2246 ISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKAD---ETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL--------SYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPH-----SPNQNRVRVI----------------GNMRP-RGNQKSIIVPEHVQRFLNG 3826
++ SK GC +C + CV+ CP+ K + S+ C CH C GC G + C F S + I FV LS + + R+ +++ L+ + TPS PN + L ++ + I ++LG G FG+VY G W + +D K+ V IKVL + E +DE +MASV H H RL+G+ + +L +S MP G + Y+++NK ++ + LL W QIA GM YLE+ H++HRDLA RNVL+ HV+ITDFGL+K+++ ++ E GG VP++W+A+E++ Y+H++DVW+Y VT+WE+ TF T PY+ + A EI + KG RL QP IC++D+Y++M+KCW +D E RP F L EF + + YL P+ + + + +++ + D Y P+ SP+ +R +++ GN+ P R + +P+ RFL+G
Sbjct: 571 LTCSKPGPDGCVECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQGCTGPELKDCREYKPF------------------SGMSVIAAGVVGGILAFVILS----------------------LGVAVLVRRRHIKRKRTLRRLLQERELVEPLTPSGEAPNQSLLRILKETEFKKI---KVLGSGAFGTVYKGLWVPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTSTVQL-VSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADEKEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVIQGDERMHLPSPTDSKFYRSLMSGVDLDESMDADEYLMPNHGFFSSPSTSRTQLLHSVSLNSSIGSCQNRNGNLFPVRESLMLRYIPDPTDRFLDG 1080 HSP 2 Score: 182.185 bits (461), Expect = 6.446e-46 Identity = 167/633 (26.38%), Postives = 266/633 (42.02%), Query Frame = 2
Query: 173 MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNI-YISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKIT---------KTCEPCHKDCHSRSITRLPVCTGP 2008
M LL N +K + +NCT + + N++ E DL FL I+E+ G + I + +PL NLR+IRG + L + +++ + + S ++ + L SL I+ G + + + + ++ ++W +++ K +K K C +G CW P + CQ F+K C+ RC + D CCN C GCT + C+AC+ D+N C+ CPP + N T PN + F C+ CP ++ G C C+ YE D +C C+ LC ++C+ + + S++ + NCTT G V I + P + L ++ I+GS+ + P + SLS NL+ I T SL I I++LGL++L+ I + + N KLCY + +K + +++ + V N ADP C C C + GCWGPGP C SC + C C + G + + CL+C EC + TCS D C+ C H + CV C + K T + C+ CH++C CTGP
Sbjct: 42 MTLLSTVDEHYQNMVK--MYSNCT-----VILENLEITYTSHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLRIIRGHT----------LYDGLALAVLSNYNNSKGLRE-LPLISLTEILKGGVKFAHNPYLCNVETIQWADIMSSKDSSQFV-KFESTTSKDCKMCHSDCYNGSCWAPGRANCQTFTKLTCAEQCSGRCKGPKPSD--CCNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGKYNFGATCVKNCPHNYVVTDHGACVRSCSPGTYEVDEDGVRKCKKCEGLCPKVCSGLGVGN----LVGVMSINSSNIDSFENCTTINGDVLILKTTLNGDTFTKTPKMDPAKLNVFRTVKEITGSLLVQY--WPKNMPSLSPFENLEVIRGRTKHQGTVSLGIGKLPITHLGLRALREISDGDVSISANAKLCYNSPEHWKRLFRSE--DQVARPMQN--ADPATCAALNQTCDEMCTPE-GCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECE-VNMTCLECDPECRPLNGSLTCSKPGPDGCV-ECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQG-------CTGP 633
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: ENSAMXT00000016431.2 (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103032492]) HSP 1 Score: 251.136 bits (640), Expect = 3.166e-68 Identity = 125/319 (39.18%), Postives = 186/319 (58.31%), Query Frame = 2
Query: 2732 TPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYI 3679
TPS N L+ EF ++LG G FG+VY G W + +D K+ V IKVL E +DE +MASV H H RL+G+ + +L I+ MP G + Y+ +N+ ++ + LL W QIA GM YLE + ++HRDLA RNVL+ NHV+ITDFGL+K++N N+ E GG VP++W+A+E++ Y+H++DVW+Y VT+WE+ TF PY+ + A EI + KG RL QP IC++D+Y++M+KCW +DP+ RP F L +EF + + YL EQ + + + + +
Sbjct: 637 TPSGAAPNQALLRILKETEF-KKVKVLGSGAFGTVYKGLWIPEG------------EDVKIPVAIKVLREVTSPKANKEILDEAYVMASVDHPHICRLLGICLTSTVQL-ITQLMPFGCLLDYIRENQDNIGSQNLLNWCVQIAKGMNYLEEHRLVHRDLAARNVLVKTPNHVKITDFGLAKLLNANEKEYHSDGGKVPIKWMALESILHWTYTHQSDVWSYGVTVWELMTFGAKPYDGIPAQEISGLLEKGERLPQPSICTIDVYMIMVKCWMIDPDSRPRFRELSSEFTKMARDPTRYLVIQGDEQLHLSGSTDRRV 941 HSP 2 Score: 166.392 bits (420), Expect = 3.690e-41 Identity = 167/617 (27.07%), Postives = 274/617 (44.41%), Query Frame = 2
Query: 191 SQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKII--NRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIS-TSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADP-KLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPG----YLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRT----------HFLNKITKTCEPCHKDC 1966
SQ+ ++ + +NCT V N+ I +V G DL FL I+E+ G + I ++++ +PL NLR+IRG S LY + F +++ + +NS + SI +G L E P R ++ GK C K C +G CW P CQ ++ C ++ C++RC D CCN C GCT ++ C+AC+ D+ +C+ CP + N + PN F F C+ CP ++ G C C + +E + + +C C C ++C N +++ + NCT G + I + P + L + + ++ I+G ++ ++ P L SLS NL+ I S +N I YLGL+SLK I + + KNN +LCY + ++ + ++DT TI + + + D E + +C C + GCWGPGP+ C SC +V C ++C + G Y++N +CL+C EC +T +G +DQC+ C H + S CV +C+ F++K + C+PCH +C
Sbjct: 38 SQADDHYRALMKMYSNCTVVLENLEITHV-----GENYDLSFLRSIEEVGGYVLIAINDVNVIPLENLRLIRGHS-LY--------EGKFALAVMANYHTANSSS------AESSIPTG-------------------LRELPLR-NLRGK------PCDKSCY----NGSCWAPGPENCQKLTRLICAEQ-CSHRCKGPAIAD--CCNEHCAAGCTGPLATDCLACREFKDDGMCKDACPRLMLYDPNLHQLVVNPNGKFS--FGATCVKNCPHNYVVTDHGACVRTCGDKTHEVEENGIRKCKNCNGPCPKVCN----GLGNGELAGIMTVNASNIDTFQNCTKINGDISIFATTLRGDPYTKTPKLDPAKLDYFKTVKEITG--FLLIQAWPENLTSLSPFENLEVIRGRTQQHGRVSFAALNIAHIEYLGLRSLKEISDGDVVIKNNPRLCYTNANYWRKLFRSDTQ---TIKTRDNLGDSCNSAEVQNRMCDGMCTEE-GCWGPGPSMCFSCRHVSRQGQCVDSCNILEGMPREYISN-----NMCLECDQEC-RTLNGTPTDQCV-ECAHFKDGSNCVSQCANGVPGMNNRLIWTFVDK-NRQCQPCHPNC 581
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: erbb4b (erb-b2 receptor tyrosine kinase 4b [Source:ZFIN;Acc:ZDB-GENE-030918-5]) HSP 1 Score: 252.677 bits (644), Expect = 6.477e-68 Identity = 149/485 (30.72%), Postives = 242/485 (49.90%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK----VRTFL-KADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C + +QC D ++ + C +C + CV CP +F+ K E N+ +CHPCH C GC G CI ++ P G + V V ++ + + RK +K+ L+ + + E + + + PN L ++ L+ + +ILG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NH++ITDFGL+++++ ++ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 501 CLECDAQCQKADDDGLTCTGPGPDHCVKCLHFKDGPNCVEKCPDGLQGTNSFIFKYAEANN---ECHPCHANCTQGCTGPRLQDCI----------------GMIDRTPLIAAGVIGG----LFVVVIIA----------------------LGVAVSVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KILGAGAFGTVYKGIWVPEG------------ETVKIPVAIKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFCRMARDPQRYL 924 HSP 2 Score: 183.726 bits (465), Expect = 2.386e-46 Identity = 167/625 (26.72%), Postives = 265/625 (42.40%), Query Frame = 2
Query: 206 YNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQ--KGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQ---CVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSITRLPVCTGP 2008
Y TL++ NC V GN+ I ++ DL FL I+E+TG + + + +PL NLR+IRG +RLY + AL D + + + L++L I+ G +Y+ ++F + W +++++ + P+ S C + + +G CWGP +QCQ +K C RCF D CC+ +C GGC+ + C AC D+ C +CP + N T E N + + C+ KCP + C C K E + ++ C+PC +C + C S + ++D + K NCT G F+ + V H E + + + L +R I+G L F +S L Q I+ L L+S++ I ++ NN++LCY++ + ++ + T +I +N DPK C +C C S GCWGPGP+ C+SC G C E+C + G + + VCL+C +C K TC+G D C+ C H + CV +C F+ K + C PCH +C CTGP
Sbjct: 15 YRTLRK-YYENCEVVMGNLEITSIDRSR-----DLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG-TRLY--EDRYALAIFLNYRRDGNFGLRQ-----LGLKNLTEILHGGVYVDQNKFLCHADTIHWQDIVKNARSDHLV-----VPSNSSSSCQRCHRACNGRCWGPKENQCQSLTKTVCAEQCDGRCFGPYVSD--CCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPRAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENKIKMCIPCTDICPKACDGIGTASLQTAQ----TVDSSNIDKFINCTKINGNLVFLITGIKGDVYHNIEAL---DPEKLNVFRTVREITGKTRSILT---FSGRGISLLVLKQQW-----------------ITSLQLQSMREISAGNVYITNNSQLCYYNTINWTSLFRIPTQK--ALIRNN--RDPKECIMEKMICDPLC-SDGGCWGPGPDQCLSCRFFSRGRTCVESCNLHQGDVRE-FANGSVCLECDAQCQKADDDGLTCTGPGPDHCV-KCLHFKDGPNCVEKCPDGLQGTNSFIFKYAEANNECHPCHANCTQG-------CTGP 577
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: ENSAMXT00000051131.1 (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103032492]) HSP 1 Score: 251.906 bits (642), Expect = 6.700e-68 Identity = 125/319 (39.18%), Postives = 186/319 (58.31%), Query Frame = 2
Query: 2732 TPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYI 3679
TPS N L+ EF ++LG G FG+VY G W + +D K+ V IKVL E +DE +MASV H H RL+G+ + +L I+ MP G + Y+ +N+ ++ + LL W QIA GM YLE + ++HRDLA RNVL+ NHV+ITDFGL+K++N N+ E GG VP++W+A+E++ Y+H++DVW+Y VT+WE+ TF PY+ + A EI + KG RL QP IC++D+Y++M+KCW +DP+ RP F L +EF + + YL EQ + + + + +
Sbjct: 698 TPSGAAPNQALLRILKETEF-KKVKVLGSGAFGTVYKGLW------------IPEGEDVKIPVAIKVLREVTSPKANKEILDEAYVMASVDHPHICRLLGICLTSTVQL-ITQLMPFGCLLDYIRENQDNIGSQNLLNWCVQIAKGMNYLEEHRLVHRDLAARNVLVKTPNHVKITDFGLAKLLNANEKEYHSDGGKVPIKWMALESILHWTYTHQSDVWSYGVTVWELMTFGAKPYDGIPAQEISGLLEKGERLPQPSICTIDVYMIMVKCWMIDPDSRPRFRELSSEFTKMARDPTRYLVIQGDEQLHLSGSTDRRV 1002 HSP 2 Score: 197.978 bits (502), Expect = 6.463e-51 Identity = 180/657 (27.40%), Postives = 305/657 (46.42%), Query Frame = 2
Query: 146 PEIKYCFSSMDLLDG-SQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEV-SIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS--SQFCSSLANVEWNELL-EDPTRQSVTGKCTPQPTK-CSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKII--NRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIS-TSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPG----YLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRT----------HFLNKITKTCEPCHKDCHSRSITRLPVCTGPS 2011
PE K C + + L+ SQ+ ++ + +NCT V N+ I +V G DL FL I+E+ G + I ++++ +PL NLR+IRG S ++ + N S + S+ ++ + LR+LR I+ G + I+ + C+ + ++W++++ ++ T +T + T K C K C +G CW P CQ ++ C ++ C++RC D CCN C GCT ++ C+AC+ D+ +C+ CP + N + PN F F C+ CP ++ G C C + +E + + +C C C ++C N +++ + NCT G + I + P + L + + ++ I+G ++ ++ P L SLS NL+ I S +N I YLGL+SLK I + + KNN +LCY + ++ + ++DT TI + + +A P+ CE + +C C + GCWGPGP+ C SC +V C ++C + G Y++N +CL+C EC +C G +DQC+ C H + S CV +C+ F++K + C+PCH +C CTGP
Sbjct: 22 PERKVCQGTSNKLNLLSQADDHYRALMKMYSNCTVVLENLEITHV-----GENYDLSFLRSIEEVGGYVLIAINDVNVIPLENLRLIRGHSLYEGKFALAVMANYHTANSSSAESSIPTGLRE-LPLRNLREILRGGVRIARNPRLCN-IETIKWHDIVSKESTNAVITSESTDSTCKPCDKSCY----NGSCWAPGPENCQKLTRLICAEQ-CSHRCKGPAIAD--CCNEHCAAGCTGPLATDCLACREFKDDGMCKDACPRLMLYDPNLHQLVVNPNGKFS--FGATCVKNCPHNYVVTDHGACVRTCGDKTHEVEENGIRKCKNCNGPCPKVCN----GLGNGELAGIMTVNASNIDTFQNCTKINGDISIFATTLRGDPYTKTPKLDPAKLDYFKTVKEITG--FLLIQAWPENLTSLSPFENLEVIRGRTQQHGRVSFAALNIAHIEYLGLRSLKEISDGDVVIKNNPRLCYTNANYWRKLFRSDTQ---TIKTRDNLA-PEACEVQNRMCDGMCTEE-GCWGPGPSMCFSCRHVSRQGQCVDSCNILEGMPREYISN-----NMCLECDQECRTLNGTPSCHGPGADQCV-ECAHFKDGSNCVSQCANGVPGMNNRLIWTFVDK-NRQCQPCHPNCTHG-------CTGPG 637
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003172.1 (pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 gene:ENSPMAG00000002842.1 transcript:ENSPMAT00000003172.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 258.84 bits (660), Expect = 5.084e-72 Identity = 150/459 (32.68%), Postives = 230/459 (50.11%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSL----GKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNA-NESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C +C Y CVS CP V + DE S C PCHP C +GC G C L + S CV + L + C+ R+ ++ ++ Y E + + + PN L ++ L G++LG G FG+V+ G W + +D K+ V IKVL + E +DE IMASV H H +RL+G+ S +L ++ MPLG + +Y ++K+ + ++LL WA QIA GM+YLE ++HRDLA RNVL+ HV+ITDFGL+++++ N+ E GG +P++WLA+E+++ ++H++DVW+Y VT+WE+ TF PYE + A +I + + KG RL QP IC++D+Y++M+KCW +D E RP F+ L EF + + + YL
Sbjct: 438 CVRCAHYKDGPHCVSACP-VGAQGENDEIISKYPDKNNTCQPCHPNCSHGCKGGGLLDC--------------HLIGPLFRTGSPVLAVMAVGGLFACVMLLLLAV------------------------VCVRRRNIARKRAMRRYIEKELVEPLTPSGAAPNQAQLRILKETELR---KGKMLGSGAFGTVHKGIWTPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYIMASVSHPHLVRLLGICLTPSVQL-VTQLMPLGCLLEYTREHKEHIGSQLLLNWAVQIAKGMMYLEEQRLVHRDLAARNVLVRTPQHVKITDFGLARLLDINEIEYHADGGKMPIKWLALESIQYRTFTHQSDVWSYGVTIWELMTFGGKPYEGIPARDIPELLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFKELAVEFSKMARDPQRYL 841 HSP 2 Score: 146.747 bits (369), Expect = 6.834e-36 Identity = 135/505 (26.73%), Postives = 215/505 (42.57%), Query Frame = 2
Query: 527 LRSIVSGNIYISSQFCSSLAN-VEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGD--EECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQ---GDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES-LVPIISTSLTIINT---DISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNG-MADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVREC------SRTHFLNKI---TKTCEPCHKDC 1966
L I+ G +YI N V+W +++++ + ++ + T C K C + CWG CQ KC K CA +C G ECC+SQC GC + C AC+ D+ C CPP I N T N + + IC+ +CP + C C K+E + +C C +C + C + I + N + ++D + NCT G + T +P + D L +++ I+G + I + P + + NL I ++ + + +++ +I+ LGL SL+ + ++ KNN +LCY++ K+ + ++ + + DN AD C G VC + C S+ GCWGPGP+ CISC R C E+C + G VC C EC + TC G S+ C+ C H + CV C ++K TC+PCH +C
Sbjct: 1 LSEILHGGVYIKENKHLCYHNTVDWWDIVKEGSIVNIDMDNSTTCTSCHKGCHKH-----CWGNGMKYCQ---KCTKLTCARQCDGRCHGPTPSECCHSQCAAGCDGPRDTHCFACKNFNDSGSCVSHCPPPTIYNPVTFAQGENPDVKYSYGAICVKECPHNFVVDYNSCVRACPAGKHEVEKFGKKKCETCTDVCPKAC--DGIGTGNLSRSQ--TVDATNIDTFENCTKINGNIAFLTTGIKGDDYMKIPPLDPDKLNVFRSIKEITGHLMI--QAWPENMTDFAVFENLTTIRGRVLQSVGRTFSLLVARIPNITALGLASLQEVSAGNVYLKNNERLCYYNTIKWPAVFVSE--QQTSYVHDNKPEAD---CNADGAVCDLLC-SEHGCWGPGPDQCISCRFFRRARSCVESCYITEGPYRE-HMQDAVCAPCDPECLPVNDSVTCFGPGSNSCV-RCAHYKDGPHCVSACPVGAQGENDEIISKYPDKNNTCQPCHPNC 483 HSP 3 Score: 56.9954 bits (136), Expect = 3.434e-8 Identity = 67/273 (24.54%), Postives = 107/273 (39.19%), Query Frame = 2
Query: 191 SQSSNYNTLKQDLGNNCTHVYGNI--FINNVKSESNGSEPDLE-----FLSGIKEITGSLKIRN--SNISSVPL-RNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSVT------GKCTPQPTKCSKKCMQKGKSGFCWGPLTSQ---CQIFSKCRKRMCANRCFLSE------TGDEEC--CNSQCLG-----GCTSSDSSSCIACQGVLDNNVCQPECP 907
S+S + D NCT + GNI +K + P L+ IKEITG L I+ N++ + NL IRG + ++ +F + + + ++ T + L SL+ + +GN+Y+ + + C ++W + + S C C C + G CWGP Q C+ F R R C C+++E D C C+ +CL C S+SC+ C D C CP
Sbjct: 202 SRSQTVDATNIDTFENCTKINGNIAFLTTGIKGDDYMKIPPLDPDKLNVFRSIKEITGHLMIQAWPENMTDFAVFENLTTIRGRV-------LQSVGRTFSLLVARIPNI-----TALGLASLQEVSAGNVYLKNNERLC-YYNTIKWPAVFVSEQQTSYVHDNKPEADCNADGAVCDLLCSEHG----CWGPGPDQCISCRFFR--RARSCVESCYITEGPYREHMQDAVCAPCDPECLPVNDSVTCFGPGSNSCVRCAHYKDGPHCVSACP 455
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005822.1 (pep scaffold:Pmarinus_7.0:GL476959:64997:68848:-1 gene:ENSPMAG00000005273.1 transcript:ENSPMAT00000005822.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 178.718 bits (452), Expect = 2.531e-51 Identity = 79/185 (42.70%), Postives = 124/185 (67.03%), Query Frame = 2
Query: 3158 GMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQ-NYTTNTFNNYIEIKQHEDEIS 3709
GM YLE+ ++HRDLA RNVL+ NHV+ITDFGL+K+++ N+ E GG +P++WLA+E+++ I++H++DVW+Y VTLWE+ TF PY+ + A +I + + KG RL QP IC++D+Y++M+KCW +D E RP F L EF + + YL E+ + T + +++ ED++S
Sbjct: 1 GMNYLEDRRLVHRDLAARNVLVKAPNHVKITDFGLAKLLDLNETEYHSEGGKLPIKWLALESIQQRIFTHQSDVWSYGVTLWELMTFGGKPYDGVPARDIPELLEKGERLTQPPICTIDVYMIMVKCWMIDAESRPKFRELAAEFSKMARDPTRYLVIQGDERMKLPSPTDSRFLQSLMEEDDMS 185
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 178.333 bits (451), Expect = 9.915e-46 Identity = 96/324 (29.63%), Postives = 168/324 (51.85%), Query Frame = 2
Query: 2675 RKRDKLKAYFSNANESDSQTPSP----PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
RKR L+ Y N Q +P PN L ++ L+ G++LG G FG+VY G W + + K+ V +KVL S + +DE +MASV H H +RL+G+ + +L ++ MP G + +Y+ +++ + +++L W QIA ++ ++ DL + + + + L + I+ D +P++W+A+E+++ ++H++DVW+Y VT+WE+ TF PY+ + A +I + KG RL QP +C++D+Y++M+KCW +D E RP F L T+F + + YL
Sbjct: 647 RKR-TLRKYVENERPQLVQPLTPSGAQPNQAQLRILKETELK---KGKVLGSGAFGTVYKGIWVPEG------------ESVKIAVAVKVLRDSASSKANKDILDEAYLMASVDHPHLVRLLGICMSSTTQL-VTQLMPHGCLLEYVREHRGRVGSQLILNWCVQIAKNASEIQALQMVCDDLVRLVMSLRTPPRITLASANLFQSID---DAKHWHDRDMPIKWMALESIQYRKFTHQSDVWSYGVTVWELMTFGGKPYDGISARDIPGLLEKGERLPQPPVCTIDVYMIMVKCWMIDAESRPRFSELATDFSKMARDPSRYL 950 HSP 2 Score: 116.701 bits (291), Expect = 1.431e-26 Identity = 156/648 (24.07%), Postives = 260/648 (40.12%), Query Frame = 2
Query: 173 MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLR--SLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSV---TGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIAC------QGVLDNNVC---------QPECPPK-KIINRETGIPE-PNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKI-LCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQ--IDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQ-AIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSR------THFLNKITK---TCEPCHKDCHSRSI 1981
M LL GS YNTL+ + NC V GN+ I ++ NGS DL FL I+E++G + I + + VPL NLRV+RG +RLY + + V ++ + SV + +LR L I+ G +Y+ + W+++ ++++ C S + FCWG CQ F+ C K+ C RC+ + +CC+ C GCT + C + DN +C Q + PP+ + R+ + + P F + N C+ CP E E + C PC LC ++C + K + ++D + +NCTT G F++ D ++ + P + ++L+ ++GS+ L P + L FL +L + S + +++ + ++ ++ +K+ + + C+ ++ T + D + G VC C ++ GCWGPGP C+SC + G C E+C V G + +C+ CH EC + TC G D C C++ E CV C + K C PCH +C I
Sbjct: 8 MSLL-GSAEKQYNTLR-SMYTNCEVVMGNLEITYIR---NGS--DLSFLRTIREVSGYVLIALNEVDHVPLENLRVVRG-TRLYDQ------RYALTVLLNYNDSVPEERLGLKELRLTRLTEILRGGVYVRKE----PGLPSWDDIRNRNSKENFFLPVVACDFSSVSLSGQPCHPSCKNFCWGSGPQYCQTFTSTICAKQ-CDGRCYGLDP--NQCCHKHCASGCTGPRETDCFPASSWRSRASIQDNVLCGLFFSVTIYQFDNPPRGNLALRQALVADFPAGNFVVDY-NSCVRSCPVNKTEVEDGSGVK-----------HCKPCPDNLCPKVC---DGIGSGKLKEAQ-TVDAKNIHFFSNCTTISGNLIFLRNGFDGNCHFQNGIHVKP-------RCCQSLQQLTGSLL--LNHYPVRWQVLPFLLHLDLSKPSRKQFWRLHVLLVHKSLLFMLMRYCTYVKSFQVTATVHPIFCFVSTLFGSSLYSTKSNGRHCCACDRP-------GKEGYVCDALCSAE-GCWGPGPMQCLSCKFHKRGKTCVESCSVLDGD-EREFVSGALCIACHAECMLINGSLTCHGPGPDNCT-RCRNYREGPHCVGFCPEGVPGESGELIYKYPDEDGVCHPCHYNCTQGEI 599
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010487.1 (pep scaffold:Pmarinus_7.0:GL501102:818:30108:-1 gene:ENSPMAG00000009497.1 transcript:ENSPMAT00000010487.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 167.548 bits (423), Expect = 3.088e-43 Identity = 166/625 (26.56%), Postives = 269/625 (43.04%), Query Frame = 2
Query: 191 SQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSI--DQDISVSNSIKTVIDLRSLRSIVSGNIYISSQ-FCSSLANVEWNELLEDPT-RQSVTGKCTPQ-PTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLS--ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQ------ICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIINT-DISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLN-DVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKT-----CSGLRSDQCIGGCKHAMENSMCVREC---SRTHFLNKITK------TCEPCHKDC 1966
S++ +Y +LK L C V GN+ I ++ S G DL FL ++E+ G + + ++ +PL +LR++RG M + F ++I + + ++ ++ LRSL I+SG + I+ F ++W ++LE QSV P + S+ +G S CW T+ CQ K + +CA C L T +CC+ C GCT + C+AC+ D VC CPP I NR+T + EPN + IC+ +CP+ L E C C K E + + CK E+ +C + D K S+ + + CTT G F++ +S + PE +K ++R I+G Y+ ++ + LS NL+ + + + S+ + N + LGL++L + ++ +N +LCY + ++++ D+ + + + C C C S GCWGPGP C+ C + G C E+C G + +C CH EC T C G SD C C+H + CV +C T I K C PCH +C
Sbjct: 39 SKTQHYESLKI-LYQGCEVVLGNLEITHL---SRGD--DLSFLKDVREVMGYVLVALNDFEELPLESLRIVRG---------MKLYDDKFALAIVDNGQRGLGTGLRALL-LRSLTEILSGGVNITDNPFLCHADTIKWEDILEQKNLNQSVLPYGRPDCESPASRPPCPQGCS-HCWSADTNYCQ---KLTRTICAKECTLRCYGTNTNQCCHKHCASGCTGPRDTDCLACKTFNDTGVCVMHCPPTHIYNRDTYLQEPNPDVKYSHGAICVKRCPQNFLIDENSCARSCPHEKMEVEENGVKMCKACSEKQGCPKVVCHGIGSGNLKDAK----SVSSLNVDTFSECTTINGNLVFLESGLDSDLLAHPE--------KMKVFRSVREITG--YLHIEAWLPNMTDLSVFENLEIVRGRNIRSVGYSVLVRNLPHLEVLGLRALSEVTEGSVLAQNVPRLCYVLTVNWTRLLRSPRQKADLEGVPSSSVC-VFACRAGSEACHPLCSSD-GCWGPGPEQCMQCKLFKRGRTCVESCNQNDGEVRE-FINGTLCTPCHSECLPTNGTLSCKGPTSDMCT-RCRHFKDGPYCVDKCPLGQNTEHGALIFKFPDAHNACMPCHANC 625
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: fer (fer (fps/fes related) tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-060526-234]) HSP 1 Score: 166.777 bits (421), Expect = 2.287e-42 Identity = 94/273 (34.43%), Postives = 143/273 (52.38%), Query Frame = 2
Query: 2792 IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ---NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGM---VPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEF 3592
I+ GE LGKG FG VYAG+ K S V V +K + + Q N F+ E RI+ H + +RLIGV + + ++ + G +L + L+ LL ++EQ A GM YLE+++ IHRDLA RN L+ + + ++I+DFG+S+ D + + G+ +P++W A E L G Y+ +DVW+Y + LWEIF+ + PY +++ G R+ P +C IY LML+CW E+RP F L E
Sbjct: 558 IILGEKLGKGNFGEVYAGRLK----------------ASGVPVAVKACHENLSQDLKNRFLMEARILKRYNHPNVVRLIGVCTRRTPVYIVMELVRGGDFLTFLRREGSRLSVPQLLNYSEQAAAGMAYLESHNCIHRDLAARNCLVGEASVLKISDFGMSR---QQADGVYLATGVMRQIPIKWTAPEALHYGTYTTMSDVWSYGILLWEIFSLGSSPYPGWSNKMACEQVASGYRMPPPAVCPDGIYSLMLRCWEFHAEQRPTFTELHREL 811
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 91.2781 bits (225), Expect = 7.528e-19 Identity = 80/268 (29.85%), Postives = 123/268 (45.90%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMD---EVRIMASVRH-KHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLY----LENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGI-YSHKTDVWAYAVTLWEIFTFATVPY---EFLKAHEIRDEIIKGTRLRQPD---ICSLDIYILMLKCWSVDPEER 3562
E++G+G FG VY G + K +V IKVLN D +E D E++ +AS++ + R G K + +I + GS+ L GKI K+ I +L + +++IHRD+ NVLI E +V++ DFG++ +N Q G W+A E + +G+ Y K D+W+ +T +EI T PY E L+A ++ IIK R D SL +I + C DP+ER
Sbjct: 27 EVIGRGKFGVVYKGY---------------NVKTGRV-YAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRP------GKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGT--PYWMAPEVIMEGVYYDTKVDIWSLGITTYEIAT-GNPPYCDVEALRAMQL---IIKSKPPRLEDRSYSTSLKEFIAL--CLDEDPKER 264
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: IPL1 (Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest [Source:SGD;Acc:S000006130]) HSP 1 Score: 84.7297 bits (208), Expect = 1.183e-17 Identity = 63/207 (30.43%), Postives = 98/207 (47.34%), Query Frame = 2
Query: 2951 QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEI---IKGTRLRQPDICSLDIYILMLKCWSVDPEER 3562
Q +F EV I S+ H + + G + L+ Y+ G M K L + + + QIAN + Y+ +IIHRD+ N+LI N +++TDFG S IINP ++ + G + +L+ E + Y H D WA V +E+ T A P+E E++D I ++ P S D L+LK DP++R
Sbjct: 146 QKQFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHG-PFNDILASDYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGWS-IINPPENRRKTVCGT--IDYLSPEMVESREYDHTIDAWALGVLAFELLTGAP-PFE----EEMKDTTYKRIAALDIKMPSNISQDAQDLILKLLKYDPKDR 343
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 79.7221 bits (195), Expect = 2.114e-15 Identity = 49/204 (24.02%), Postives = 98/204 (48.04%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFT 3415
+++G+G++G VY +N D V + V + + N+ M E+ ++ ++ H + ++ G K E ++ Y GS+ + + ++ L+ + Q G+ YL +IHRD+ N+L+ +N V++ DFG+S I+N + + + G + W+A E L + S +D+W+ T+ E+ T
Sbjct: 29 QVIGRGSYGVVYKA--------------INKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSS--ALTLAGTL---NWMAPEILGNRGASTLSDIWSLGATVVEMLT 213
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354]) HSP 1 Score: 78.5666 bits (192), Expect = 3.606e-15 Identity = 63/238 (26.47%), Postives = 109/238 (45.80%), Query Frame = 2
Query: 2795 MGGEILGKGTFGSVYAG------------KWKLDNGCF----DDNSSMNS-------CKDSKVDVVIKVLNHSCDQN-------EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINP-NKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFT 3415
+ G +G G+FGSVY G + ++ N D+N NS + K++ V V + +QN E+ ++ + H++ + G S +G + Y+P GS+ L N ++ + QI G+ YL +IIHRD+ N+LI + V+ITDFG+SK ++P NK + + V W++ E ++ + K D+W+ + E+FT
Sbjct: 416 LKGACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSML-NNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFT 652
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 77.411 bits (189), Expect = 9.609e-15 Identity = 72/279 (25.81%), Postives = 121/279 (43.37%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVD-------VVIK--VLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKL-LISSYMPLGSMEKYLEKNK------KSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPY---EFLKAHEIRDEIIKGT-RLRQPDICSLDIYILMLKCWSVDPEERPNFEYL 3580
E G+G GSVY + S+M ++ +D V IK VL+ + ++E+ +M RHK+ + + + + L ++ +M GS+ +E + LT + + G+ +L + HIIHRD+ + NVL+ V+ITDFG + + + G W+A E ++ Y K DVW+ + E+ PY + LKA + GT +L+ P+ SL+I + C VD R + E L
Sbjct: 550 EKAGQGASGSVYLA----ERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGT--PYWMAPEVVKQREYDEKIDVWSLGIMTIEMLE-GEPPYLNEDPLKALYLI--ATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEEL 819
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO47094 (Predicted protein; Vascular endothelial growth factor receptor-like protein [Source:UniProtKB/TrEMBL;Acc:A7RN88]) HSP 1 Score: 166.777 bits (421), Expect = 1.141e-45 Identity = 96/279 (34.41%), Postives = 148/279 (53.05%), Query Frame = 2
Query: 2807 ILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASV-RHKHCLRLIGVSYKGSEKLL--ISSYMPLGSMEKYLEKNKK---------------SLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYL 3580
+LG G FG VY G+ G D + V IK L +Q + + E++I+ V HK+ + L+G KG ++ L I + G + YL+K + T L+ A Q+A GM +L + IHRDLA RNVLI + +++ DFGL++ + N++ ++ G+VP++W+AIE+L D IYS K+DVW+Y V LWEIFT PY L ++ + ++ G R+ +P C+ +IY +M CW + PE+RP F L
Sbjct: 21 LLGSGAFGQVYLGE---TEGGIDYRRPSAISMRGNIKVAIKTLKGGATESEQKDLLSELKILIHVGSHKNIVNLLGACTKGPQRDLWIILEFCANGDLLSYLKKKRDIYDPAWCAPSEDHDVQFTQMELVSAAYQVARGMEFLASRRCIHRDLAARNVLIADDYVLKVADFGLARDVYKNEEYVKHTPGLVPIKWIAIESLTDKIYSQKSDVWSYGVLLWEIFTLGGNPYPDLHPSDVFEYLLDGKRMEKPVDCAQEIYNIMTDCWVLSPEDRPTFTEL 296
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18]) HSP 1 Score: 162.54 bits (410), Expect = 2.345e-44 Identity = 93/282 (32.98%), Postives = 147/282 (52.13%), Query Frame = 2
Query: 2810 LGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNK-KSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNF----EYLWTEFKNYSNNSETYLSYPNV 3640
LG G +G VY G WK K +K V + + + EF+ E +M ++H++ ++L+GV + +I+ +M G++ YL K K L L+ A Q+ + M YLE+ + IHRDLA RN L+ N V++ DFGLS++++ + G P++W A E L +S K+DVWA+ + LWE+ T+ PY + ++ D++ G R+ P+ C ++Y LM CW DP RP+F E L T F + + N Y+SY V
Sbjct: 20 LGGGQYGEVYEGTWK---------------KYNKTVAVKTLREETMEVEEFLKEASVMKGIKHQNLVQLLGVCTREPPFYIITEFMMNGNLLDYLRSPKGKDLDAVTLMYMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLVSEDIYTAHQ-GAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYRMPCPEGCPPEVYSLMQTCWCWDPNSRPSFKEIHEKLNTMFPSSNVNEGVYISYIKV 285
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO47097 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN91]) HSP 1 Score: 162.54 bits (410), Expect = 3.000e-44 Identity = 90/277 (32.49%), Postives = 150/277 (54.15%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASV-RHKHCLRLIGVSYKGSE--KLLISSYMPLGSMEKYL---------------EKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYL 3580
+I+G G FG V+ + G + + +CK K + + + + E++I+ + HK+ + L+G KG E L+I Y P G++ +L EK ++ T L+ + Q++ M +L + +HRDLA RNVL+ + ++I DFGL++ I + ++ G++PV+W+AIE L D +Y+H +DVW++ V LWEIFT PY L A+E+ +++G R+ QP+ C ++Y LML+CW DP +RP F L
Sbjct: 20 DIVGTGAFGQVFLAE---AVGISNKQVTRVACKGLKENAT------DSEYRDLLSELKILMHIGEHKNIVNLLGACTKGRECDLLVIIEYCPHGNLLNFLRKRRDVFEATWSPPTEKPDETFTLTDLVITSFQVSRAMQFLASRRCVHRDLAARNVLVGENYVMKIADFGLARDIYKEEHYVKTTAGLLPVKWMAIEALVDQVYTHSSDVWSFGVLLWEIFTLGGSPYPGLPANEVYQYLMEGQRMAQPEDCPQEMYDLMLRCWQHDPAQRPTFTQL 287
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO47110 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNB1]) HSP 1 Score: 159.844 bits (403), Expect = 1.472e-43 Identity = 86/279 (30.82%), Postives = 155/279 (55.56%), Query Frame = 2
Query: 2810 LGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVR----HKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNK------------KSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKN 3598
LG+G FG V G+ ++ +++ V IK+L D+ + D +R + + H++ + LIG G +I+ ++ G++ + L +++ L+GK LLK A A GM ++ N +HRDLATRNVL+ ++ +ITDFGLS+ I + + GG +P++W+A E+L D +Y+ ++D+W++ V +WE+++F +PY + +E+ ++ G RL +P +C +IY +M+ CW+ +PE RP+F L T ++
Sbjct: 14 LGEGEFGIVMEGELLIE-------------EEAPRKVAIKMLKSDADRTDHKDMLRELDMFKGIGQHENVVSLIGACTLGMPLYIITEFIAGGTLLELLRESRCITSSYVNANLVSKLSGKDLLKLALGAARGMRHISGNRFVHRDLATRNVLVTEDLTAKITDFGLSRDIYSDGIYLNAKGGKLPLKWMAPESLLDYVYTTQSDIWSFGVLMWEVWSFGAMPYSAVVPNELLSMLMSGFRLSRPPLCPEEIYDVMMSCWNAEPEVRPSFAKLCTVLES 279
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO49126 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGW8]) HSP 1 Score: 160.614 bits (405), Expect = 3.539e-43 Identity = 98/338 (28.99%), Postives = 163/338 (48.22%), Query Frame = 2
Query: 2792 IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASV-RHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEK------NKKSLTGKI---------LLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFG-GMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRV 3745
I GE++G G FG V G ++ ++ V +K LN D+ F+ E+ +M + +H + + ++G + LI+ Y P G + YL + SL G+ LL +A QIA GM YL +HRDLA RN+LI ++N V+I+DFGL++ + + + ++ G +P++W+A E + +++ K+DVWA+ V LWEI T PY E ++ G R+ +PD+CS ++Y +M CW+ PE+RP F L + + + + YI++ + E SY A S + R+
Sbjct: 18 IAFGEVVGSGAFGKVTKATIVGLPGGPENKETV---------VAVKKLNAMATMEDRRNFLSEIEMMKQLGKHLNIVSILGCVTHAGQLCLITEYCPYGDLRNYLRAIRDKVSTRDSLAGRAPGRELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVYESSEYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKEFYKKLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKLRNQLEQLMDREDEL-----------------YIDVNFEDAEYSYLATDSSSSGRL 329
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: egfra (epidermal growth factor receptor [Source:NCBI gene;Acc:101159776]) HSP 1 Score: 255.373 bits (651), Expect = 1.206e-69 Identity = 157/470 (33.40%), Postives = 235/470 (50.00%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGK-CHPCHPQCNGCYGV----DKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGN------SNENICVFVF---LSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDK-LKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C C+ Y +CV C L+ + + + K C C P+C G +C C NF+ CV CP N+C G + +I A V +L L ++ F L R+ KR + ++ + TPS PN L ++ + I ++LG G FG+VY G W + +D K+ V IKVL + E +DE +MASV + H RL+G+ + +L I+ MP G + Y+++ K ++ + LL W QIA GM YLE H++HRDLA RNVL+ NHV+ITDFGL+K++N ++ E GG VP++W+A+E++ Y+H++DVW+Y VT+WE+ TF T PY+ + A EI + KG RL QP IC++D+Y++M+KCW +D E RP F L EF + + YL
Sbjct: 440 CFACRDYSRGGRCVDSC----NILEGEPREAVMNKTCVECDPECQRMNGTATCSGPGNCAKCANFQ-------DGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQGSTGLSMIAAGVVGGLLTVLVTGLSVFVLLRRRYIKRKRTMRRLLQERELVEPLTPSGQAPNQALLRILKESEFKKI---KVLGSGAFGTVYKGLWVPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYVMASVENPHVCRLLGICLTSTVQL-ITQLMPYGCLLDYVKEKKDNIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPNHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESILTRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGDRLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIGEFTKMARDPSRYL 882 HSP 2 Score: 136.732 bits (343), Expect = 5.697e-32 Identity = 123/457 (26.91%), Postives = 190/457 (41.58%), Query Frame = 2
Query: 671 KKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPP--KKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYE-RQGD--QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK-----TCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKIT---------KTCEPCHKDCHSRS 1978
KKC +G CW P CQ +K + C+ RC D CCN C GCT + C+AC+ D+ VC+ CP + N +P PN + F C+ CP ++ G C C+ YE +G +C C C ++C + ++ S++ + NCT G + S + P + L + ++ I+G Y+ ++ P + SLS NL+ I S S+ I DISYLGL+SLK I + + N LCY + +K + K+ T T+++ + C +C + GCWGPGP+ C +C + G C ++C + G +K C++C EC + TCSG C C + + CV C + T C+ CHK+C S
Sbjct: 119 KKCHSSCFNGSCWAPGPQYCQTLTKLNCAQQCSKRCKGPSPSD--CCNEHCAAGCTGPRPTDCLACRDFRDDGVCKDSCPGLMRYDPNLHLLVPNPNGKYS--FGATCVKNCPHNYVVTDHGACVRTCSGNTYEVDEGGIRKCAKCNGPCPKVC---NGLGTGNLTHT-LSINATNIDSFKNCTKINGNIAFIHTSIYGDKFTKTPKMDPAKLDVFKTVKEITG--YLWIQTWPKNMSSLSPFENLEIIRGRTKQGSRSVAITQLDISYLGLRSLKEISDGDVVIIKNHNLCYTNRSHWKGLFKSKT---QTLMN--------------STCDRKCAAD-GCWGPGPDMCFACRDYSRGGRCVDSCNILEGE-PREAVMNKTCVECDPECQRMNGTATCSG--PGNC-AKCANFQDGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQGS 543
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: ENSORLT00000004471.2 (melanoma receptor tyrosine-protein kinase [Source:NCBI gene;Acc:101169984]) HSP 1 Score: 252.292 bits (643), Expect = 5.181e-68 Identity = 185/649 (28.51%), Postives = 295/649 (45.45%), Query Frame = 2
Query: 2183 IVILEPCHDLCSQCTIRTDQRISLSKTDW----KGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC------NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN-----------YKETSGNSN------ENICVFVFLSG-XXXXXXXXXXXXXXXXXXXXXXXTKFCLA---RKGKRKRDKLKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL----SYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEH--VQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSN----GNTNYHDFHSRPDVSPSSLTIEYLEP 3991
IV P D+C DQ+ S SK W C C+ + CV C ++ + E G C CHP+C C+G + C C +FK + CV CP Y + +G C LSG V + + +I+ F L R+ +K+ L+ + TPS PN L ++ + + +LG G FG+V+ G W + ++ ++ V IKVL + E +DE +MASV H H RL+G+ S +L ++ MP G + Y+ ++K + + LL W QIA GM YLE H++HRDLA RNVL+ NH++ITDFGL+K++ ++ E GG VP++W+A+E++ Y+H++DVW+Y VT+WE+ TF + PY+ + A EI + +G RL QP IC++D+Y++M+KCW +DP RP F+ L EF + + YL P+ + + + ++++ D Y P N+ + + P G +V E+ R++ P L + + + N +++ + S N NY D + L+ E LEP
Sbjct: 510 IVDQTPPVDVCEGQNQTCDQQCS-SKGCWGPGTNMCLSCQYFNRKQHCVERCNLLQGEPREVEVE---GSCVECHPECLVMTGTQTCHGPGPDQCSQCAHFKDGSH-------CVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQGCSGPGLSGCSRTTTHSSLAVGVVSGLLVAVIVLLFVLVYVRRQRIKKKRTLRRLLQEKELVEPLTPSGQAPNQALLRILKETEFKKV---RVLGSGAFGTVFKGLWVPEG------------ENVRIPVAIKVLREATSPKANQEVLDEAYVMASVDHPHVCRLLGICLTSSVQL-VTQLMPYGCLLDYVRQHKDRICAQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHIKITDFGLAKLLTADEKEYHADGGKVPIKWMALESILQWTYTHQSDVWSYGVTVWELMTFGSKPYDGIAASEIATVLERGERLPQPPICTIDVYMIMVKCWMIDPSSRPKFKELIMEFSQMARDPSRYLVIRGDLPSPSDSRFFSRLLSSDDMEEIADADEYLLP-----NKRLIPPDSHPCGATNGHLVRENSGALRYITDPTQSGLDKDDIFGHEYMNQSVSETSRSSRLSEVLNPNYEDLSLASSTASLHLSPENLEP 1126 HSP 2 Score: 183.341 bits (464), Expect = 2.487e-46 Identity = 166/649 (25.58%), Postives = 290/649 (44.68%), Query Frame = 2
Query: 167 SSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQ-FCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETG--IPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNK---ITK------TCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNK 2041
S++ L G++ +Y ++ + + +NC+ V N+ I DL FL I+E+ G + I +++++VPL NLR+IRG + LY ++ + N +I ++ ++ + L L I++G + +++ ++ ++W ++++ SV K C ++C + CW CQ F+K C ++ RC S +CCN C GCT ++ C+AC+ D+ +C+ CPP + N ++ + PN + F C+ CP + EG C C+ YE + + +C C+ C + C + + +++ ++ NCT G + SF + +P + L++ ++ I+G + I + P + SLS NL+ I ++ S ++ D + +LGL+SLK + + K+N LCY + + + T I+ D +CE + C QC S+ GCWGPG N C+SC C E C + G + C++CH EC +TC G DQC C H + S CVR C ++ I K C+ CH++C C+G PG GC++
Sbjct: 50 SNLLTLLGTREYHYESMVR-MYSNCSVVLENLEITYTLENQ-----DLSFLQSIQEVGGYVLIAMNDVATVPLVNLRLIRGQN-LYDKFALLVMSNYHSNNITGAPRYTSGLRQ-LQLSRLTEILNGGVKVTNNPLLCNMEKIQWWDIVDKARNFSVLLKFDDYKRDC-ERCDPGCVNDSCWAAGPDHCQKFTKLVCAEQCGPGRC--SGPKPLDCCNQHCAAGCTGPLATDCLACKNFNDDGICKDSCPPLNLYNHKSQQVVENPNAKYS--FGATCVKACPHNYVVTEGSCVRACSPNTYEVEENGVQRCKRCEGPCPKACDGVGVGRLTN----TIAVNSSNIESFRNCTKINGDIVFLKSSFSGDQHYNIPPMDPKKLEYFRTVKEITGHLLI--QTWPENMTSLSVFENLEIIRGRSLFVNKYSFVVVGADNLHWLGLRSLKELSAGNVRLKDNKLLCYSKAMNWSYLFRDKT----QIVDQTPPVD--VCEGQNQTCDQQCSSK-GCWGPGTNMCLSCQYFNRKQHCVERCNLLQGEPREVEVEGS-CVECHPECLVMTGTQTCHGPGPDQC-SQCAHFKDGSHCVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQG-------CSG----PGLSGCSR 659
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: egfra (epidermal growth factor receptor [Source:NCBI gene;Acc:101159776]) HSP 1 Score: 251.521 bits (641), Expect = 9.400e-68 Identity = 128/331 (38.67%), Postives = 191/331 (57.70%), Query Frame = 2
Query: 2651 FCLARKGKRKRDK-LKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
F L R+ KR + ++ + TPS PN L ++ + I ++LG G FG+VY G W + +D K+ V IKVL + E +DE +MASV + H RL+G+ + +L I+ MP G + Y+++ K ++ + LL W QIA GM YLE H++HRDLA RNVL+ NHV+ITDFGL+K++N ++ E GG VP++W+A+E++ Y+H++DVW+Y VT+WE+ TF T PY+ + A EI + KG RL QP IC++D+Y++M+KCW +D E RP F L EF + + YL
Sbjct: 658 FVLLRRRYIKRKRTMRRLLQERELVEPLTPSGQAPNQALLRILKESEFKKI---KVLGSGAFGTVYKGLWVPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYVMASVENPHVCRLLGICLTSTVQL-ITQLMPYGCLLDYVKEKKDNIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPNHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESILTRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGDRLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIGEFTKMARDPSRYL 972 HSP 2 Score: 174.096 bits (440), Expect = 2.085e-43 Identity = 163/634 (25.71%), Postives = 265/634 (41.80%), Query Frame = 2
Query: 182 LDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELL---EDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPP--KKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYE-RQGD--QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK-----TCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKIT---------KTCEPCHKDCHSRSITRLPVCTGPS 2011
L GS+ +Y + + +NCT V N+ I + + DL FL I+E+ G + I + + +PL NLR+IRG S ++ L NS + + ++ ++ I++G I + ++ ++W +++ + P + P KC C +G CW P CQ +K + C+ RC D CCN C GCT + C+AC+ D+ VC+ CP + N +P PN + F C+ CP ++ G C C+ YE +G +C C C ++C + ++ S++ + NCT G + S + P + L + ++ I+G Y+ ++ P + SLS NL+ I S S+ I DISYLGL+SLK I + + N LCY + +K + K+ T + + +N A C + C +C + GCWGPGP+ C +C + G C ++C + G +K C++C EC + TCS C C + + CV C + T C+ CHK+C CTGP
Sbjct: 35 LLGSKDDHYLNMVKTY-SNCTVVLENLEITYMDNNH-----DLSFLKSIEEVGGYVLIALNTATRIPLENLRIIRGHSLYEGEFALSVLVNSDKGTGTTELLLTKL----------TEILAGGIKFGNNQLCNVETIQWFDIVNPDKKPKMELPMASNNPLCKKCHSSCF----NGSCWAPGPQYCQTLTKLNCAQQCSKRCKGPSPSD--CCNEHCAAGCTGPRPTDCLACRDFRDDGVCKDSCPGLMRYDPNLHLLVPNPNGKYS--FGATCVKNCPHNYVVTDHGACVRTCSGNTYEVDEGGIRKCAKCNGPCPKVCN---GLGTGNLTHT-LSINATNIDSFKNCTKINGNIAFIHTSIYGDKFTKTPKMDPAKLDVFKTVKEITG--YLWIQTWPKNMSSLSPFENLEIIRGRTKQGSRSVAITQLDISYLGLRSLKEISDGDVVIIKNHNLCYTNRSHWKGLFKSKTQS--ANVDENASA--TACALMNSTCDRKCAAD-GCWGPGPDMCFACRDYSRGGRCVDSCNILEGE-PREAVMNKTCVECDPECQRMNGTATCSASGPGNC-AKCANFQDGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQG-------CTGPG 624
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: erbb4b (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:101165111]) HSP 1 Score: 251.906 bits (642), Expect = 1.247e-67 Identity = 152/482 (31.54%), Postives = 244/482 (50.62%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCN-------GCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN--------YKETSGNSNENICVFVFLSG-------------XXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C CK + C+ C + ++ + N S+ C C QC C+G HC+ C +FK N CVE CP +K N+ + C G L+ V+ + + + + RK +K+ L+ + + E + + + PN L ++ L+ I +ILG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL+++++ N+ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + +I D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 477 CLSCKFFSRGRSCIKSCNLYQGEIR-EYANGSV--CVECDSQCEQGDDNTLTCHGSGPEHCVKCLHFKDGPN-------CVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIGWMDRTPLIAAGVIGGLFMVVIMALSVAVSVRRKNIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIW------------IPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLDVNEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFTRMARDPQRYL 932 HSP 2 Score: 160.614 bits (405), Expect = 3.336e-39 Identity = 160/624 (25.64%), Postives = 260/624 (41.67%), Query Frame = 2
Query: 206 YNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKS--GFCWGPLTSQCQIFSKCRKRMCANRCFLSETGD--EECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSI-TRLPVCTG 2005
Y TL++ NC V GN+ I ++ N L FL I+E+TG + + + +PL NLR+IRG ++LY + +L D + + + + L +L I+ G +Y+ ++F + W +++++P V PT S C + +S G CWGP +QCQ +K +CA +C +G +CC+ +C GGC + C AC D+ C +CP N T E N R + C+ KCP PC + + ++D + K NCT G F+ + V H E + + + L ++R I+G Y++++ P + L SNL I SL ++ IS L+SLK I + N +LCY++ + + ++ N ++ +N +P C + VC C S GCWG GP+ C+SC G C ++C + G + + VC++C +C + TC G + C+ C H + CV +C + F+ K + C PCH +C I RL C G
Sbjct: 42 YRTLRKYY-ENCEVVMGNLEITSIDRSRN-----LTFLRSIREVTGYVLVALNQFDHLPLENLRIIRG-TKLY--EDRYSLAIFLNYRRDGNFGLRH-----LGLINLAEILYGGVYVDQNKFLCHADTIHWQDIVKNPGFHPVV-----VPTNSSVTCPKCHRSCNGRCWGPKDNQCQSLTKT---VCAEQCDGRCSGPYVSDCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFFYNPTTFQLEHNPSARYTYGAFCVKKCP---------------------------PCDGIGTGTLQAAQ------------TVDSSNIDKFVNCTKINGNLVFLITGIKGDVYHNIEAL---DPEKLNVFRSVREITG--YLNIQSWPDNMTDLIVFSNLATIGGRALYSGISLLVLKQQGISSFLLQSLKEISAGNVHIAENKQLCYYNTVNWTRLFRSP--NQKVLVRNN--RNPLECARGHMVCDPLC-SDDGCWGSGPDQCLSCKFFSRGRSCIKSCNLYQGEIRE-YANGSVCVECDSQCEQGDDNTLTCHGSGPEHCV-KCLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIG 592
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: erbb4b (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:101165111]) HSP 1 Score: 252.292 bits (643), Expect = 1.366e-67 Identity = 152/482 (31.54%), Postives = 244/482 (50.62%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCN-------GCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN--------YKETSGNSNENICVFVFLSG-------------XXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
C CK + C+ C + ++ + N S+ C C QC C+G HC+ C +FK N CVE CP +K N+ + C G L+ V+ + + + + RK +K+ L+ + + E + + + PN L ++ L+ I +ILG G FG+VY G W + + K+ V IK+LN + EFMDE IMAS+ H H +RL+GV + +L ++ MP G + Y+ ++K ++ ++LL W QIA GM+YLE ++HRDLA RNVL+ NHV+ITDFGL+++++ N+ E GG +P++W+A+E + ++H++DVW+Y VT+WE+ TF PY+ + +I D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L EF + + + YL
Sbjct: 515 CLSCKFFSRGRSCIKSCNLYQGEIR-EYANGSV--CVECDSQCEQGDDNTLTCHGSGPEHCVKCLHFKDGPN-------CVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIGWMDRTPLIAAGVIGGLFMVVIMALSVAVSVRRKNIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIW------------IPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLDVNEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFTRMARDPQRYL 970 HSP 2 Score: 184.111 bits (466), Expect = 2.081e-46 Identity = 167/627 (26.63%), Postives = 274/627 (43.70%), Query Frame = 2
Query: 206 YNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKS--GFCWGPLTSQCQIFSKCRKRMCANRCFLSETGD--EECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQ---CVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSI-TRLPVCTG 2005
Y TL++ NC V GN+ I ++ N L FL I+E+TG + + + +PL NLR+IRG ++LY + +L D + + + + L +L I+ G +Y+ ++F + W +++++P V PT S C + +S G CWGP +QCQ +K +CA +C +G +CC+ +C GGC + C AC D+ C +CP N T E N R + C+ KCP + C C K E + + C+PC +C + C + + + ++D + K NCT G F+ + V H E + + + L ++R I+G Y++++ P + L SNL I SL ++ IS L+SLK I + N +LCY++ + + ++ N ++ +N +P C + VC C S GCWG GP+ C+SC G C ++C + G + + VC++C +C + TC G + C+ C H + CV +C + F+ K + C PCH +C I RL C G
Sbjct: 42 YRTLRKYY-ENCEVVMGNLEITSIDRSRN-----LTFLRSIREVTGYVLVALNQFDHLPLENLRIIRG-TKLY--EDRYSLAIFLNYRRDGNFGLRH-----LGLINLAEILYGGVYVDQNKFLCHADTIHWQDIVKNPGFHPVV-----VPTNSSVTCPKCHRSCNGRCWGPKDNQCQSLTKT---VCAEQCDGRCSGPYVSDCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFFYNPTTFQLEHNPSARYTYGAFCVKKCPHNFVVDHNSCVRACPTNKMEVEDNHIKMCIPCTDICPKAC---DGIGTGTLQAAQ-TVDSSNIDKFVNCTKINGNLVFLITGIKGDVYHNIEAL---DPEKLNVFRSVREITG--YLNIQSWPDNMTDLIVFSNLATIGGRALYSGISLLVLKQQGISSFLLQSLKEISAGNVHIAENKQLCYYNTVNWTRLFRSP--NQKVLVRNN--RNPLECARGHMVCDPLC-SDDGCWGSGPDQCLSCKFFSRGRSCIKSCNLYQGEIRE-YANGSVCVECDSQCEQGDDNTLTCHGSGPEHCV-KCLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIG 630
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1) HSP 1 Score: 2568.5 bits (6656), Expect = 0.000e+0 Identity = 1300/1317 (98.71%), Postives = 1303/1317 (98.94%), Query Frame = 2
Query: 56 MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINT+ISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVD NHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSG EL LVILAVVF+FV+ TLF IITKFC AR GKRKRDKLKAYFSNA ESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNY TNTFNNYIEIKQHEDEISY APHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFL PPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI
Sbjct: 1 MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYKTNTFNNYIEIKQHEDEISYDAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLTEPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 1317
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1) HSP 1 Score: 2517.27 bits (6523), Expect = 0.000e+0 Identity = 1279/1323 (96.67%), Postives = 1287/1323 (97.28%), Query Frame = 2
Query: 77 WIYLHILLISLIFY-------------RYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
+ H+L++S Y + SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINT+ISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVD NHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSG EL LVILAVVF+FV+ TLF IITKFC AR GKRKRDKLKAYFSNA ESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNY TNTFNNYIEIKQHEDEISY APHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFL PPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI
Sbjct: 3 FTLFHLLILSKFIYFGDSKPNATDTSQSLTYSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYKTNTFNNYIEIKQHEDEISYDAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLTEPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 1325
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1) HSP 1 Score: 1768.05 bits (4578), Expect = 0.000e+0 Identity = 916/929 (98.60%), Postives = 919/929 (98.92%), Query Frame = 2
Query: 56 MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA 2842
MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINT+ISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVD NHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSG EL LVILAVVF+FV+ TLF IITKFC AR GKRKRDKLKAYFSNA ESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA
Sbjct: 1 MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA 929
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1) HSP 1 Score: 1717.98 bits (4448), Expect = 0.000e+0 Identity = 895/935 (95.72%), Postives = 903/935 (96.58%), Query Frame = 2
Query: 77 WIYLHILLISLIFY-------------RYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA 2842
+ H+L++S Y + SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINT+ISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVD NHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSG EL LVILAVVF+FV+ TLF IITKFC AR GKRKRDKLKAYFSNA ESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA
Sbjct: 3 FTLFHLLILSKFIYFGDSKPNATDTSQSLTYSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA 937
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000016935.1 (SMESG000016935.1) HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0 Identity = 436/1365 (31.94%), Postives = 666/1365 (48.79%), Query Frame = 2
Query: 86 LHILLISLIFY-----RYSDSLIEYPEIKYCFSSM---DLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSL--ANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQK-----GKSG----FCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCK-----------ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP--IISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKV-CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHF--LNKITK--TCEPCHKDCHSRS--ITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC-NGC-YGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYK--------------ETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQT------PSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC--DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--VEQNYTTNT-FNNYIEIKQ---------------HEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPV-NFSKTS-NITLNGSFNKSNGNTNYH 3931
+H+LL ++ + S+ +YP + C S +++ Y LG CTH+YGN+ I+++ NGS+PDL FL I EI+GSL I N+++ +PL NL+VIRG + D++ + N E + + IDLR+LR+I+S N+ IS N++W+++L+DPT Q + +P+ + KC + G+ G FC+GP ++CQ +KC K C ++TG E C+ +C GGC S C C ++ ++ C C P+ N G+ +K R +C ++CP LL+Q C +C F +++ G++C+ C LC + T+++ + N+ KY SL+ L +L NCT G + ID SF K+ + + + L+N+R I G L K+ +L+FLSNL+ I V +++++ I I +LGLK LK + K N CY D ++ I + + S N DP +C+ Q CWGPG C SCA + G C + C PGY + + C CH C + C+G C G C++A+E + CV+ CS F N + TC+ CH C + CTGPSN G GGC+KC+ +I + Q C++ + G++ S H + + + EPCH +C C+ T+++ + C QCKGY+ D+KCV C ++ E +C CH +C NGC D C C N KL +++ FSCV CP + E + NS + +F+ LSG LV + + F R ++KA +SN E D + PPNM + +I +L F + LG G FG VY G WK+ DN +N ++VVIKV+++S +EF++E +IMASV H+HCL LIGV + L+S+Y GS++KYL++N K ++ +LKWA+QIA+GM YL IIHRDLA RNVL+ ++++QITDFGL+++++ D + I G VP+RWLAIETL YS TDVWAY VTLWEIFT+A PYE L EI+ + +G RL QP+I +L++Y++M+KCW DP RP+F L + F+ + + + +L P+ V Q Y + I++ Q DE S+ A N + +I N + + KS + + RN+ E + NFSK N L+ ++ + N NY
Sbjct: 1 MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYKYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSE---------NGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTGEDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTG-EIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP--NHIFGMDSKDK-LRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLC-NLATIDKFYPKNNRKY---SLNKQTLMQLTNCTLILGDLDIDDISFNKNGVTVPMLYH-----HLKNVREIIG--LFSLVTFRTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFLGLKKLKKVYGKISIGGTNGT-CYLDRIPWEEISPDNRVK----FSCNKTCDP--------LCTGQ------CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTSNNQY-LCHKGSCPKGFYQSVINQNISHLHKKIVHQSS-----CEPCHSMCRTCSGPTNEK--------RMCHQCKGYFLDNKCVKECDNMKNVTMKLEIGD---ECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLY----------FRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPR---QDNKYIN------LEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAK-------RNISLERIKNFSKLDLNKILSPKSHRESKNFNYQ 1279 The following BLAST results are available for this feature:
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30009712 ID=SMED30009712|Name=epidermal growth factor receptor 1|organism=Schmidtea mediterranea sexual|type=transcript|length=4149bpback to top protein sequence of SMED30009712-orf-1 >SMED30009712-orf-1 ID=SMED30009712-orf-1|Name=SMED30009712-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1318bp MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNback to top Aliases
The feature 'epidermal growth factor receptor 1' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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