epidermal growth factor receptor 1

Overview
Nameepidermal growth factor receptor 1 (AEE89453.1)
Smed IDSMED30009712
Length (bp)4149
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of epidermal growth factor receptor 1 (SMED30009712) t-SNE clustered cells

Violin plots show distribution of expression levels for epidermal growth factor receptor 1 (SMED30009712) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of epidermal growth factor receptor 1 (SMED30009712) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for epidermal growth factor receptor 1 (SMED30009712) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30009712

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 40

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30009712SMESG000070834.1 Contig6490newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30009712SMESG000070834.1 Contig6490uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
pharynxSMED30009712SMESG000070834.1 dd_Smed_v4_8641_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30009712SMESG000070834.1 dd_Smed_v4_8641_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30009712SMESG000070834.1 dd_Smed_v4_8641_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30009712SMESG000070834.1 dd_Smed_v4_8641_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30009712SMESG000070834.1 dd_Smed_v4_8641_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30009712SMESG000070834.1 dd_Smed_v4_8641_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30009712SMESG000070834.1 Contig29192newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30009712SMESG000070834.1 Contig29192uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30009712SMESG000070834.1 Contig6490newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30009712SMESG000070834.1 Contig6490uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30009712SMESG000070834.1 Contig48699uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30009712SMESG000070834.1 Contig48699newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30009712SMESG000070834.1 Contig30490uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30009712SMESG000070834.1 Contig30490newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
pharynxSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
gutSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
esophagusSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
mouthSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
pigment cellSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
pharynx epitheliumSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
gutSMED30009712SMESG000070834.1 Contig29100newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
eyeSMED30009712SMESG000070834.1 Contig29100newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
gutSMED30009712SMESG000070834.1 Contig29100uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
eyeSMED30009712SMESG000070834.1 Contig29100uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
epidermisSMED30009712SMESG000070834.1 dd_Smed_v4_8641_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
pharynxSMED30009712SMESG000070834.1 HM777018.1smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
gutSMED30009712SMESG000070834.1 HM777018.1smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
pigment cup cellSMED30009712SMESG000070834.1 HM777018.1smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
mouthSMED30009712SMESG000070834.1 HM777018.1smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
neoblastSMED30009712SMESG000070834.1 HM777018.1smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
parenchymal cellSMED30009712SMESG000070834.1 HM777018.1smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
pharynxSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
gutSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
pigment cup cellSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
mouthSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
neoblastSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
parenchymal cellSMED30009712SMESG000070834.1 HM777018smed_ncbi_20200123PMID:27122174
Barberán et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432])

HSP 1 Score: 257.299 bits (656), Expect = 4.523e-69
Identity = 152/483 (31.47%), Postives = 240/483 (49.69%), Query Frame = 2
Query: 2219 QCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            QC    D  ++        CT+C  +     CV  CP          F  AD       +CHPCHP C  GC G   + CI+     +  LP++    L +                   I V V L+                            + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   ++LG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G + +Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  532 QCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-----------AGVIGGLFILVIVGLT------------------------FAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 959          

HSP 2 Score: 197.593 bits (501), Expect = 2.064e-50
Identity = 162/597 (27.14%), Postives = 260/597 (43.55%), Query Frame = 2
Query:  236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
            NC  V GN+ I +++        DL FL  ++E+TG + +  +    +PL NLR+IRG ++LY  +   AL        D +  +       + L++L  I++G +Y+  ++F      + W +++ +P   ++T   T   + C +    K  +G CWGP  + CQ  ++      C  RC+     D  CC+ +C GGC+    + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +    C PC  +C + C      S      S  ++D   + K  NCT   G +              +   + + L     +R I+G  +++++  P  +   S  SNL  I   V     SL I+    I+ L  +SLK I    I+  +N+ LCY+    +  +    T+N   +I DN  A+   C   G VC+  C S  GCWGPGP+ C+SC     G IC E+C +  G     ++ S +C++C  +C K      TC G   D C   C H  +   CV +C         F+ K     + C PCH +C
Sbjct:   29 NCEVVMGNLEITSIEHNR-----DLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRKAEN--CTAEGMVCNHLCSSD-GCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGS-ICVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNC 595          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432])

HSP 1 Score: 257.299 bits (656), Expect = 4.717e-69
Identity = 152/483 (31.47%), Postives = 240/483 (49.69%), Query Frame = 2
Query: 2219 QCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            QC    D  ++        CT+C  +     CV  CP          F  AD       +CHPCHP C  GC G   + CI+     +  LP++    L +                   I V V L+                            + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   ++LG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G + +Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  558 QCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-----------AGVIGGLFILVIVGLT------------------------FAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985          

HSP 2 Score: 197.593 bits (501), Expect = 2.103e-50
Identity = 173/650 (26.62%), Postives = 282/650 (43.38%), Query Frame = 2
Query:   77 WIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
            W+++  LL++    + SDS       +   SS+  L+      Y  L++    NC  V GN+ I +++        DL FL  ++E+TG + +  +    +PL NLR+IRG ++LY  +   AL        D +  +       + L++L  I++G +Y+  ++F      + W +++ +P   ++T   T   + C +    K  +G CWGP  + CQ  ++      C  RC+     D  CC+ +C GGC+    + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +    C PC  +C + C      S      S  ++D   + K  NCT   G +              +   + + L     +R I+G  +++++  P  +   S  SNL  I   V     SL I+    I+ L  +SLK I    I+  +N+ LCY+    +  +    T+N   +I DN  A+   C   G VC+  C S  GCWGPGP+ C+SC     G IC E+C +  G     ++ S +C++C  +C K      TC G   D C   C H  +   CV +C         F+ K     + C PCH +C
Sbjct:    8 WVWVS-LLVAAGTVQPSDSQSVCAGTENKLSSLSDLE----QQYRALRKYY-ENCEVVMGNLEITSIEHNR-----DLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRKAEN--CTAEGMVCNHLCSSD-GCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGS-ICVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNC 621          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432])

HSP 1 Score: 256.529 bits (654), Expect = 7.211e-69
Identity = 152/483 (31.47%), Postives = 240/483 (49.69%), Query Frame = 2
Query: 2219 QCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            QC    D  ++        CT+C  +     CV  CP          F  AD       +CHPCHP C  GC G   + CI+     +  LP++    L +                   I V V L+                            + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   ++LG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G + +Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  558 QCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-----------AGVIGGLFILVIVGLT------------------------FAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985          

HSP 2 Score: 196.438 bits (498), Expect = 4.636e-50
Identity = 173/650 (26.62%), Postives = 282/650 (43.38%), Query Frame = 2
Query:   77 WIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
            W+++  LL++    + SDS       +   SS+  L+      Y  L++    NC  V GN+ I +++        DL FL  ++E+TG + +  +    +PL NLR+IRG ++LY  +   AL        D +  +       + L++L  I++G +Y+  ++F      + W +++ +P   ++T   T   + C +    K  +G CWGP  + CQ  ++      C  RC+     D  CC+ +C GGC+    + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +    C PC  +C + C      S      S  ++D   + K  NCT   G +              +   + + L     +R I+G  +++++  P  +   S  SNL  I   V     SL I+    I+ L  +SLK I    I+  +N+ LCY+    +  +    T+N   +I DN  A+   C   G VC+  C S  GCWGPGP+ C+SC     G IC E+C +  G     ++ S +C++C  +C K      TC G   D C   C H  +   CV +C         F+ K     + C PCH +C
Sbjct:    8 WVWVS-LLVAAGTVQPSDSQSVCAGTENKLSSLSDLE----QQYRALRKYY-ENCEVVMGNLEITSIEHNR-----DLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRKAEN--CTAEGMVCNHLCSSD-GCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGS-ICVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNC 621          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB2 (erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:3430])

HSP 1 Score: 241.121 bits (614), Expect = 1.646e-64
Identity = 153/489 (31.29%), Postives = 250/489 (51.12%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC---NG---CYGVDKNHCIHCNNF------------------------KLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSP--PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVL--NHSCDQN-EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN 3637
            C  C  +    +CV  C +V   L  +  N+    C PCHP+C   NG   C+G + + C+ C ++                        K P+ E     +C + CP N   +  + ++  C         L  +I AVV + ++  L ++       R+ K ++  ++         +  TPS   PN   + ++    L  +   ++LG G FG+VY G W  D             ++ K+ V IKVL  N S   N E +DE  +MA V   +  RL+G+    + +L ++  MP G +  ++ +N+  L  + LL W  QIA GM YLE+  ++HRDLA RNVL+   NHV+ITDFGL+++++ ++ E    GG VP++W+A+E++    ++H++DVW+Y VT+WE+ TF   PY+ + A EI D + KG RL QP IC++D+Y++M+KCW +D E RP F  L +EF   + + + ++   N
Sbjct:  528 CVNCSQFLRGQECVEEC-RVLQGLPREYVNAR--HCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEG----AC-QPCPINCTHSCVDLDDKGCP-AEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKV---KVLGSGAFGTVYKGIWIPDG------------ENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL-VTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN 991          

HSP 2 Score: 170.629 bits (431), Expect = 3.555e-42
Identity = 153/590 (25.93%), Postives = 249/590 (42.20%), Query Frame = 2
Query:  182 LDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDIS-VSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETG-DEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQE-GECKTQCTFRKYERQGD----QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES-LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVREC 1906
            L  S  ++ + L+  L   C  V GN+ +  + + ++     L FL  I+E+ G + I ++ +  VPL+ LR++RG      + ++  L N   ++    ++  S      + LRSL  I+ G + I  + Q C     + W ++     + ++T   T +   C   C    K   CWG  +  CQ  ++    +CA  C   +     +CC+ QC  GCT    S C+AC     + +C+  CP     N +T    PN   R  F   C+  CP   L  + G C   C     E   +    +C  C   C ++C    +    + +    ++    +++ A C    G +    ESF             + L+  E L  I+G +YI     P  L  LS   NLQ I   ++   + SLT+    IS+LGL+SL+ + +      +NT LC+     +  + +    +   + + N   D   C   G  C   C ++  CWGPGP  C++C+    G  C E C V  G L      ++ CL CH EC     + TC G  +DQC+  C H  +   CV  C
Sbjct:   35 LPASPETHLDMLRH-LYQGCQVVQGNLELTYLPTNAS-----LSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQ-DTILWKDIFHKNNQLALTLIDTNRSRAC-HPCSPMCKGSRCWGESSEDCQSLTR---TVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVR----AVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYI--SAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNP--HQALLHTANRPEDE--CVGEGLACHQLC-ARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQG-LPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCV-ACAHYKDPPFCVARC 600          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Match: ERBB2 (erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:3430])

HSP 1 Score: 240.35 bits (612), Expect = 1.671e-64
Identity = 152/485 (31.34%), Postives = 249/485 (51.34%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC---NG---CYGVDKNHCIHCNN------------------------FKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSP--PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVL--NHSCDQN-EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C  C  +    +CV  C +V   L  +  N+    C PCHP+C   NG   C+G + + C+ C +                        +K P+ E     +C + CP N   +  + ++  C         L  +I AVV + ++  L ++       R+ K ++  ++         +  TPS   PN   + ++    L  +   ++LG G FG+VY G W  D             ++ K+ V IKVL  N S   N E +DE  +MA V   +  RL+G+    + +L ++  MP G +  ++ +N+  L  + LL W  QIA GM YLE+  ++HRDLA RNVL+   NHV+ITDFGL+++++ ++ E    GG VP++W+A+E++    ++H++DVW+Y VT+WE+ TF   PY+ + A EI D + KG RL QP IC++D+Y++M+KCW +D E RP F  L +EF   + + + ++
Sbjct:  252 CVNCSQFLRGQECVEEC-RVLQGLPREYVNAR--HCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEG----AC-QPCPINCTHSCVDLDDKGCP-AEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKV---KVLGSGAFGTVYKGIWIPDG------------ENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL-VTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFV 711          

HSP 2 Score: 89.7373 bits (221), Expect = 2.842e-17
Identity = 73/249 (29.32%), Postives = 109/249 (43.78%), Query Frame = 2
Query: 1178 LKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES-LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVREC 1906
            +++ A C    G +    ESF             + L+  E L  I+G +YI     P  L  LS   NLQ I   ++   + SLT+    IS+LGL+SL+ + +      +NT LC+     +  + +    +   + + N   D   C   G  C   C ++  CWGPGP  C++C+    G  C E C V  G L      ++ CL CH EC     + TC G  +DQC+  C H  +   CV  C
Sbjct:   85 IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISA--WPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNP--HQALLHTANRPED--ECVGEGLACHQLC-ARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQG-LPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCV-ACAHYKDPPFCVARC 324          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348])

HSP 1 Score: 406.371 bits (1043), Expect = 4.813e-120
Identity = 379/1329 (28.52%), Postives = 588/1329 (44.24%), Query Frame = 2
Query:  239 CTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDK-----CVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
            C  VYGN+ I  +++       ES  S  D          + F   ++EI GSL I  +NI  +    LRVI GD     HD+  AL           I  ++ +  V+ +R LR I +G++ I    + C     ++W ELL DP  Q V      + T   + C Q GKS           CWG   + CQ ++     + C+ +CF S  T   ECC+S CLGGCT     +CIAC     + +C   CP +KI N +TG    N   R    N C+ +CP  LL +   C   C+    Y+   D  +C  C+   C +ICT++              L    LK L  C       QID    ++H          + LK LE ++ +S   YI +    F    L FL NLQ IE   +  +  +L I    D+  L L SLK+IK  A+    N +LCY     + +I+ +   ++   ++     D KLCE    VC   C+ + GCWG  P  C+ C   +    C E C  + G+L N   TS  C +C  EC +TC+GL    C+  C+H         N M CV +C  +HF  +    CE CH  C+         CTGP +  G GGC +C+  +   +  +  C Q++ +N           +   + +I  +    VI       C +C+I      S  +   +    CK   +        C+  CP V +F+  D  N+   KCH    Q   C       C  C NF + + +   +  CV  CP N   ++  + E  C+   ++  +    ++ +  +   F +  +   F L    + +R   K   +   +    TP      PNM+ + +I S  L+  +  + LG G FG+V+AG +                K+ K+ V IKV      Q +E ++E   M  +RH + L++IG         +++ Y PLG+++ +L+ +K++L  +  + +  QIA+GM YLE   ++HRDLATRNVL+ K NHV+ITDFGLSKI+  + D + I  G V ++WLAIE      Y+H +DVWA+ VT WEI TF   PY+ +    I + +  G RL QP  CS D+Y  +L+CW  DP+ RP FE L+  FK +    + +L   N         E+ + T      F+  I+ + + D+              ++  PH    NR++ + + R +                  P  + +    V ++  +N       + SNG     D++++P+ +PSS +  Y EP
Sbjct:    5 CRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1232          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348])

HSP 1 Score: 407.142 bits (1045), Expect = 5.468e-120
Identity = 393/1388 (28.31%), Postives = 610/1388 (43.95%), Query Frame = 2
Query:   86 LHILLISLIFYRYSDSLIEYPEIKYCFSSMDLL-----DGSQSSNYNTLKQDLGN---NCTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDK-----CVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
            L I+ I L F+  S++ +     K C S  D L     +G        + +DL      C  VYGN+ I  +++       ES  S  D          + F   ++EI GSL I  +NI  +    LRVI GD     HD+  AL           I  ++ +  V+ +R LR I +G++ I    + C     ++W ELL DP  Q V      + T   + C Q GKS           CWG   + CQ ++     + C+ +CF S  T   ECC+S CLGGCT     +CIAC     + +C   CP +KI N +TG    N   R    N C+ +CP  LL +   C   C+    Y+   D  +C  C+   C +ICT++              L    LK L  C       QID    ++H          + LK LE ++ +S   YI +    F    L FL NLQ IE   +  +  +L I    D+  L L SLK+IK  A+    N +LCY     + +I+ +   ++   ++     D KLCE    VC   C+ + GCWG  P  C+ C   +    C E C  + G+L N   TS  C +C  EC +TC+GL    C+  C+H         N M CV +C  +HF  +    CE CH  C+         CTGP +  G GGC +C+  +   +  +  C Q++ +N           +   + +I  +    VI       C +C+I      S  +   +    CK   +        C+  CP V +F+  D  N+   KCH    Q   C       C  C NF + + +   +  CV  CP N   ++  + E  C+   ++  +    ++ +  +   F +  +   F L    + +R   K   +   +    TP      PNM+ + +I S  L+  +  + LG G FG+V+AG +                K+ K+ V IKV      Q +E ++E   M  +RH + L++IG         +++ Y PLG+++ +L+ +K++L  +  + +  QIA+GM YLE   ++HRDLATRNVL+ K NHV+ITDFGLSKI+  + D + I  G V ++WLAIE      Y+H +DVWA+ VT WEI TF   PY+ +    I + +  G RL QP  CS D+Y  +L+CW  DP+ RP FE L+  FK +    + +L   N         E+ + T      F+  I+ + + D+              ++  PH    NR++ + + R +                  P  + +    V ++  +N       + SNG     D++++P+ +PSS +  Y EP
Sbjct:   11 LLIIPIFLTFFGNSNAQL----WKRCVSPQDCLCSGTTNGISRYGTGNILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1293          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348])

HSP 1 Score: 405.216 bits (1040), Expect = 3.359e-119
Identity = 379/1329 (28.52%), Postives = 589/1329 (44.32%), Query Frame = 2
Query:  239 CTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWF-----DDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
            C  VYGN+ I  +++       ES  S  D          + F   ++EI GSL I  +NI  +    LRVI GD     HD+  AL           I  ++ +  V+ +R LR I +G++ I    + C     ++W ELL DP  Q V      + T   + C Q GKS           CWG   + CQ ++     + C+ +CF S  T   ECC+S CLGGCT     +CIAC     + +C   CP +KI N +TG    N   R    N C+ +CP  LL +   C   C+    Y+   D  +C  C+   C +ICT++              L    LK L  C       QID    ++H          + LK LE ++ +S   YI +    F    L FL NLQ IE   +  +  +L I    D+  L L SLK+IK  A+    N +LCY     + +I+ +   ++   ++     D KLCE    VC   C+ + GCWG  P  C+ C   +    C E C  + G+L N   TS  C +C  EC +TC+GL    C+  C+H         N M CV +C  +HF  +    CE CH  C+         CTGP +  G GGC +C+  +   +  +  C Q++ +N           +   + +I  +    VI       C +C+I      S  +   +    CK   +     +  C+  CP V +F+  D  N+   KCH    Q   C       C  C NF + + +   +  CV  CP N   ++  + E  C+   ++  +    ++ +  +   F +  +   F L    + +R   K   +   +    TP      PNM+ + +I S  L+  +  + LG G FG+V+AG +                K+ K+ V IKV      Q +E ++E   M  +RH + L++IG         +++ Y PLG+++ +L+ +K++L  +  + +  QIA+GM YLE   ++HRDLATRNVL+ K NHV+ITDFGLSKI+  + D + I  G V ++WLAIE      Y+H +DVWA+ VT WEI TF   PY+ +    I + +  G RL QP  CS D+Y  +L+CW  DP+ RP FE L+  FK +    + +L   N         E+ + T      F+  I+ + + D+              ++  PH    NR++ + + R +                  P  + +    V ++  +N       + SNG     D++++P+ +PSS +  Y EP
Sbjct:   78 CRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1305          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348])

HSP 1 Score: 405.216 bits (1040), Expect = 3.438e-119
Identity = 379/1329 (28.52%), Postives = 588/1329 (44.24%), Query Frame = 2
Query:  239 CTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDK-----CVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
            C  VYGN+ I  +++       ES  S  D          + F   ++EI GSL I  +NI  +    LRVI GD     HD+  AL           I  ++ +  V+ +R LR I +G++ I    + C     ++W ELL DP  Q V      + T   + C Q GKS           CWG   + CQ ++     + C+ +CF S  T   ECC+S CLGGCT     +CIAC     + +C   CP +KI N +TG    N   R    N C+ +CP  LL +   C   C+    Y+   D  +C  C+   C +ICT++              L    LK L  C       QID    ++H          + LK LE ++ +S   YI +    F    L FL NLQ IE   +  +  +L I    D+  L L SLK+IK  A+    N +LCY     + +I+ +   ++   ++     D KLCE    VC   C+ + GCWG  P  C+ C   +    C E C  + G+L N   TS  C +C  EC +TC+GL    C+  C+H         N M CV +C  +HF  +    CE CH  C+         CTGP +  G GGC +C+  +   +  +  C Q++ +N           +   + +I  +    VI       C +C+I      S  +   +    CK   +        C+  CP V +F+  D  N+   KCH    Q   C       C  C NF + + +   +  CV  CP N   ++  + E  C+   ++  +    ++ +  +   F +  +   F L    + +R   K   +   +    TP      PNM+ + +I S  L+  +  + LG G FG+V+AG +                K+ K+ V IKV      Q +E ++E   M  +RH + L++IG         +++ Y PLG+++ +L+ +K++L  +  + +  QIA+GM YLE   ++HRDLATRNVL+ K NHV+ITDFGLSKI+  + D + I  G V ++WLAIE      Y+H +DVWA+ VT WEI TF   PY+ +    I + +  G RL QP  CS D+Y  +L+CW  DP+ RP FE L+  FK +    + +L   N         E+ + T      F+  I+ + + D+              ++  PH    NR++ + + R +                  P  + +    V ++  +N       + SNG     D++++P+ +PSS +  Y EP
Sbjct:   71 CRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1298          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Match: R151.1 (pep chromosome:WBcel235:III:7218813:7221186:1 gene:WBGene00020106.1 transcript:R151.1c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R151.1)

HSP 1 Score: 173.326 bits (438), Expect = 6.738e-46
Identity = 94/282 (33.33%), Postives = 161/282 (57.09%), Query Frame = 2
Query: 2792 IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASV-RHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKK------SLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSN 3607
            I+ G ++G+G FG V+ G  +  NG               + V +K L  +    ++ EF+ E+++M +V +H + + + G       + +I  Y+P G ++ YL+  +K      ++  K  L +  QIA GM +LE+  IIHRDLA RN+L+     ++I+DFG+S+   P    +++  G++P+RWL+ E ++D  YS+K+DVWA+ V LWEI T    PY  +   +I +++ +G RL QP  CS D+YILM  CW++  E+RP+F  + ++ +  +N
Sbjct:  189 IVVGAVIGEGAFGQVFKGILRGPNG-------------QVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSR---PGV-YIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKIEQIAN 453          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071654)

HSP 1 Score: 489.189 bits (1258), Expect = 1.097e-148
Identity = 356/1217 (29.25%), Postives = 573/1217 (47.08%), Query Frame = 2
Query:  140 EYPEIKYCFSSMDLLD--GSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQD---ISVSNSIKTVIDLRSLRSIVSGNIYISSQF-CSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHR---------PEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES--LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-DSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCY--QNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADE-TNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKL-PENE-----NLTLFSCVESCP-----SNYKETSGN--------------SNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLAR-KGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYP 3634
            E+ + K C  +   L    ++  +Y  L+ D   NCT+V GN+ +  + +E+     DL FL  I+E+TG + I + ++  V    L++IRG             +  F +S++++   + V+ S    +++  LR +++G +   + +    +  ++W+E++ + T        T    +C K C +    G CWG     CQ FSK  C  +    RC+  +    ECC+  C GGCT      CIAC+   D  VC+ ECPP +  N  T + E N   +  +   C+ +CP  LL   G C   C   K ++ G +CVPC   C + C    +    +            +    NCT   G ++I  ++F   +         P  +P+ + + L+    ++ I+G  Y++++    +  +LS+  NL+ I    L+  +  +L I+ + +  L +++LK I + ++  ++N  LCY    ++  I K         +++N  AD  LCE+ G +CS QC+   GCWG G + C++C N      C  +C    GY++N     ++ C  CH EC +TC+G  +D C   C H  +   CV EC +  + ++    C  CH  C          CTGP +T G G C  C   I+  D  V+RC    +   +GYF                 +      +   CH LC  CT              + C++C  Y   ++C + CP       AD  T+    +C  CHP+CNGC G   + C  C NFKL   NE     N T+F+C   CP      NY+ T+                +N ++ +   ++G            L     +  ++T  C  + K K++  K+    S   +S+   PS    N   +    + E   GG +LG G FG VY G W  +             ++ K+ V IK L  S       EF+ E  IMASV H + L+L+ V    S+ +LI+  MPLG +  Y+  N+  +  K LL W+ QIA GM YLE   ++HRDLA RNVL+   + V+ITDFGL+K+++ + +E +  GG +P++WLA+E +R+ +++ K+DVWA+ VT+WE+ TF   P+E + A +I D I  G +L QP+ICSLDIY  +L CW +D   RP F+ L T F  ++ +   YL+ P
Sbjct:   95 EFVKGKICIGTKSRLSVPSNKEHHYRNLR-DRYTNCTYVDGNLELTWLPNENL----DLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRG-------------RTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPK-CHESCTHG-CWGEGPKNCQKFSKLTCSPQCAGGRCYGPKP--RECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDK-GGECVPCNGPCPKTCPGVTVLHAGN------------IDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPL-DPERLEVFSTVKEITG--YLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEP--EQKVWVNENLRAD--LCEKNGTICSDQCNED-GCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAYKFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKYNDR--GVCRECHATCDG--------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGR-----AVCRKCHPLCELCTNYGYHE--------QVCSKCTHYKRREQCETECP-------ADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITG----------AVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGG-VLGMGAFGRVYKGVWVPEG------------ENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMS-SQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIP 1208          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071653)

HSP 1 Score: 487.649 bits (1254), Expect = 1.676e-148
Identity = 355/1214 (29.24%), Postives = 571/1214 (47.03%), Query Frame = 2
Query:  152 IKYCFSSMDLLD--GSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQD---ISVSNSIKTVIDLRSLRSIVSGNIYISSQF-CSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHR---------PEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES--LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-DSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCY--QNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADE-TNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKL-PENE-----NLTLFSCVESCP-----SNYKETSGN--------------SNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLAR-KGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN 3637
            +K C  +   L    ++  +Y  L+ D   NCT+V GN+ +  + +E+     DL FL  I+E+TG + I + ++  V    L++IRG             +  F +S++++   + V+ S    +++  LR +++G +   + +    +  ++W+E++ + T        T    +C K C +    G CWG     CQ FSK  C  +    RC+  +    ECC+  C GGCT      CIAC+   D  VC+ ECPP +  N  T + E N   +  +   C+ +CP  LL   G C   C   K ++ G +CVPC   C + C    +    +            +    NCT   G ++I  ++F   +         P  +P+ + + L+    ++ I+G  Y++++    +  +LS+  NL+ I    L+  +  +L I+ + +  L +++LK I + ++  ++N  LCY    ++  I K         +++N  AD  LCE+ G +CS QC+   GCWG G + C++C N      C  +C    GY++N     ++ C  CH EC +TC+G  +D C   C H  +   CV EC +  + ++    C  CH  C          CTGP +T G G C  C   I+  D  V+RC    +   +GYF                 +      +   CH LC  CT              + C++C  Y   ++C + CP       AD  T+    +C  CHP+CNGC G   + C  C NFKL   NE     N T+F+C   CP      NY+ T+                +N ++ +   ++G            L     +  ++T  C  + K K++  K+    S   +S+   PS    N   +    + E   GG +LG G FG VY G W  +             ++ K+ V IK L  S       EF+ E  IMASV H + L+L+ V    S+ +LI+  MPLG +  Y+  N+  +  K LL W+ QIA GM YLE   ++HRDLA RNVL+   + V+ITDFGL+K+++ + +E +  GG +P++WLA+E +R+ +++ K+DVWA+ VT+WE+ TF   P+E + A +I D I  G +L QP+ICSLDIY  +L CW +D   RP F+ L T F  ++ +   YL+ P 
Sbjct:   50 MKVCIGTKSRLSVPSNKEHHYRNLR-DRYTNCTYVDGNLELTWLPNENL----DLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRG-------------RTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPK-CHESCTHG-CWGEGPKNCQKFSKLTCSPQCAGGRCYGPKP--RECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDK-GGECVPCNGPCPKTCPGVTVLHAGN------------IDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPL-DPERLEVFSTVKEITG--YLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEP--EQKVWVNENLRAD--LCEKNGTICSDQCNED-GCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAYKFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKYNDR--GVCRECHATCDG--------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGR-----AVCRKCHPLCELCTNYGYHE--------QVCSKCTHYKRREQCETECP-------ADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITG----------AVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGG-VLGMGAFGRVYKGVWVPEG------------ENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMS-SQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPG 1160          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Shark (gene:FBgn0015295 transcript:FBtr0087244)

HSP 1 Score: 203.371 bits (516), Expect = 4.590e-53
Identity = 112/298 (37.58%), Postives = 168/298 (56.38%), Query Frame = 2
Query: 2726 SQTPSPPNMNHLLVISSDNLEFIMGGEIL------GKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVL-NHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLK-WAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIF-GGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEF 3592
            S TPS P+      + +  L F +  E L      G G FGSV++G W L            + ++S+++V IK+L +   ++ EF+ E  +M  + HK  +RLIG++ KG   +++    PLGSM +Y+  +   +T    LK WA QIA GM YLE+ H +HRDLA RN+L+   +  +I+DFG+S+ + P   E Q   GG  P+RW A E+   GI+SH +DVW++ VT+WE+F+    PY  +   +    +  G RL QP++C   IY +M  CW   P++RP F YL TEF
Sbjct:  637 SGTPSTPSATE---VEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKS--------GAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIA-KGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYL-TEF 920          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0330693)

HSP 1 Score: 176.407 bits (446), Expect = 6.199e-47
Identity = 102/294 (34.69%), Postives = 157/294 (53.40%), Query Frame = 2
Query: 2735 PSPPNMNHLLVISSDNLEF----IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNH-SCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGK--ILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGM-VPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEF 3592
            P PP       +S D  E     +M  E LG G FG V  GKW+                   +D  +K++   +  +++F++E ++M  ++H + ++L GV  K     +++ YM  GS+  YL +++K+L G   +LL    Q++ GM YLE ++ IHRDLA RN L+  EN V++ DFGL++ +    D+    GG   P++W   E L    +S K+DVWAY V +WEIFT   +PY  LK  E+ + + +G  L +P  C+ +IY +M  CWS  PEERP F  L  + 
Sbjct:  185 PVPPTAG----LSHDKWEIHPMELMLMEELGSGQFGVVRRGKWR-----------------GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 455          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0330692)

HSP 1 Score: 178.333 bits (451), Expect = 1.010e-46
Identity = 102/294 (34.69%), Postives = 157/294 (53.40%), Query Frame = 2
Query: 2735 PSPPNMNHLLVISSDNLEF----IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNH-SCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGK--ILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGM-VPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEF 3592
            P PP       +S D  E     +M  E LG G FG V  GKW+                   +D  +K++   +  +++F++E ++M  ++H + ++L GV  K     +++ YM  GS+  YL +++K+L G   +LL    Q++ GM YLE ++ IHRDLA RN L+  EN V++ DFGL++ +    D+    GG   P++W   E L    +S K+DVWAY V +WEIFT   +PY  LK  E+ + + +G  L +P  C+ +IY +M  CWS  PEERP F  L  + 
Sbjct:  286 PVPPTAG----LSHDKWEIHPMELMLMEELGSGQFGVVRRGKWR-----------------GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 556          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: egfra (epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) [Source:ZFIN;Acc:ZDB-GENE-030918-1])

HSP 1 Score: 254.603 bits (649), Expect = 1.080e-68
Identity = 148/432 (34.26%), Postives = 224/432 (51.85%), Query Frame = 2
Query: 2732 TPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIR--NLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
            TPS   PN   L ++     + I   ++LG G FG+V+ G W  +             ++ K+ V IKVL  +       E MDE  +MASV H H  RL+G+    + +L I+  MP G +  Y+ +NK  +  + LL W  QIA GM YLE  H++HRDLA RNVL+    HV+ITDFGL+K++N ++ E    GG VP++W+A+E+++   Y+H++DVW+Y VT+WE+ TF T PY+ + A EI   + KG RL QP IC++D+Y++M+KCW +D E RP F  L  EF   + +   YL                   + Q +D +   +P      R  + G +    +    +VP H   F + P      LL+         +++LN SF    GN N  + +  P V  +S+ + Y+   T R 
Sbjct:  692 TPSGEAPNQALLRILKETEFKKI---KVLGSGAFGTVHKGLWVPEG------------ENVKIPVAIKVLREATSPKANKEIMDEAYVMASVEHPHVCRLLGICLTSTVQL-ITQLMPYGCLLDYVRENKDRIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESIQHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFTKMARDPSRYL-------------------VIQGDDRMHLPSPSDSKFYRSLMSGELDEAVDADEYLVPNH--SFFSSPSTSRTQLLH---------SVSLNSSF----GNCNSRNGNGYP-VRENSMVLRYIPDPTERF 1072          

HSP 2 Score: 194.512 bits (493), Expect = 1.177e-49
Identity = 179/662 (27.04%), Postives = 286/662 (43.20%), Query Frame = 2
Query:  101 ISLIF-YRYSDSLIEYPEIKYCFSSMDLLD--GSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIY--ISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDE--ECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYE-RQGD--QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNK---------ITKTCEPCHKDCHSRSITRLPVCTGP 2008
            I L F    S S    PE K C  + + L   G+   +Y  L + +  NCT V  N+ I ++  +      DL FL  I+E+ G + I  + +S +PL NLR+IRG S LY      A+  ++  SI+Q +         + L SL  I+ G +   +++  C+ +  +EW ++L   +  ++          C K C     +G CWG    +CQ  +K    +CA +C     G    +CCN  C  GCT    + C+AC+   D   C+  CP   + +  T    PN Y +  F   C+  CP   ++   G C   C+   YE  +G   +C  C+ LC ++C    +    +      S++   +    NCT   G V I + +F           +   L  L  ++ I+G + I L   P  + SLS   NL+ I        T S  +  T I++LG++SL+ I +  +    N  LCY   + +K + K+     V +I +    D   C  + + C+  C +  GCWGPGP  C  C +   G  C  +C +  G     +  +K C++C  EC      +TC+G   D+C   C +  +   CV  C +     K         +T  C+PCH++C          CTGP
Sbjct:    7 IGLFFTLLLSGSFCATPEKKVCQGANNKLTLLGTVEDHYQVLLR-MYRNCTVVLENLEITHITEKY-----DLSFLKSIQEVGGYVLIAVNTVSKIPLENLRIIRGHS-LYEDKFALAVLVNYNNSIEQGVKE-------LPLTSLTEILKGGVRFNMNNHLCN-VGTIEWADILNMKSLPTIVSHNISYGKNCGK-CDPSCFNGSCWGTGPDKCQRMTKV---ICAEQCSGRCKGPRPIDCCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQLAPNPYGKYSFGATCIKTCPHNYVVTDHGACVRTCSPGTYEVDEGGVRKCKRCEGLCPKVCNGLGMGPLANV----LSINATNIDSFENCTKISGNVAILSTTFRGDPHTNTSGLDPAKLSVLSTVKEITGYLMIQL--WPESMQSLSAFENLEVIRGRTKTQGTYSFAVTKTAITHLGMRSLREISDGDVSIVKNKNLCYSSPEHWKRLFKSKQ-QSVKMIEN---MDAATCANQNSTCNEMCTAD-GCWGPGPTMCFGCEHYSRGKHCVASCNLLNGEPREYE-VNKTCMECDPECLLMNETQTCNGPGPDKCT-VCANYKDGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENCTQG-------CTGP 629          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64])

HSP 1 Score: 244.202 bits (622), Expect = 1.250e-67
Identity = 115/297 (38.72%), Postives = 180/297 (60.61%), Query Frame = 2
Query: 2744 PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            PN   L ++    L+ +   +ILG G FG+VY G W            +   +  K+ V IK+LN S       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ +++ ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NH++ITDFGL++++  N+ E     G +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:   12 PNQAQLRILKETELKRV---KILGTGAFGTVYKGIW------------VPEGETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYL 292          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4])

HSP 1 Score: 248.825 bits (634), Expect = 8.851e-67
Identity = 119/327 (36.39%), Postives = 195/327 (59.63%), Query Frame = 2
Query: 2657 LARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   +ILG G FG VY G W  +             +  K+ V IK+LN S       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ +++ ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NH++ITDFGL+++++ ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   +I D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  460 IRRKSIKKKRALRRFLETELVEPLTPSGAAPNQAQLRILKETELKRV---KILGAGAFGMVYKGIWVPEG------------ETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYL 770          

HSP 2 Score: 141.739 bits (356), Expect = 2.081e-33
Identity = 114/434 (26.27%), Postives = 186/434 (42.86%), Query Frame = 2
Query:  761 CANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQ---CVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSITRLPVCTGP 2008
            C  RCF     +  CC+ +C GGC     + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +Q   C+PC  +C ++C   +       + +  ++D   ++K  NCT   G +              +   + D L     +R I+G  +++++  P  +  L   SNL  I         SL I+    I+ L  +SL+ I    ++  NN++LC++    + ++ +T T     +I +N   +P+ C +   +C   C S+ GCWGPGP+ C+SC     G  C ++C +  G +    +   VC++C  +C K      TC G   D C+  C H  +   CV +C         F+ K  +T   C PCH +C          CTGP
Sbjct:   12 CDGRCFGPYVSN--CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCTDICPKVC---DGIGTGSLQMAQ-TVDSSNIEKFVNCTKINGNLIFLITGIKGDMFHGIRALDPDRLNVFRTVREITG--FLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQR--ALIKNN--REPRECSKEQKICDPLC-SEAGCWGPGPDQCLSCKYFSRGKTCVKSCNLYYGDVRE-FANGSVCVECDSQCEKAGEKGLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQG-------CTGP 423          

HSP 3 Score: 60.4622 bits (145), Expect = 1.830e-8
Identity = 88/317 (27.76%), Postives = 131/317 (41.32%), Query Frame = 2
Query:  236 NCTHVYGNI--FINNVKSES----NGSEPD-LEFLSGIKEITGSLKIRN--SNISSVPL-RNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS--SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKK---CMQKGKSGFCWGPLTSQ---CQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPK--KIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEI 1126
            NCT + GN+   I  +K +        +PD L     ++EITG L +++   N++ + +  NL  I G S LY+  S+  L+  +  S+                +SLR I +GN+Y++  SQ C   + V W  L    T++++  K   +P +CSK+   C        CWGP   Q   C+ FS  R + C   C L      E  N      C   DS    A +  L    C    P    K ++ + G   PN          C+ KCP+GL   +G         KY    ++C PC   C Q CT   I
Sbjct:  153 NCTKINGNLIFLITGIKGDMFHGIRALDPDRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIGGRS-LYSGISLLILKQRWITSLQ--------------FQSLREISAGNVYMTNNSQLC-FYSTVNWTSLFRTSTQRALI-KNNREPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYFS--RGKTCVKSCNLYYGDVREFANGSV---CVECDSQCEKAGEKGL---TCHGPGPDHCVKCLHLKDG---PN----------CVEKCPDGL---QG---ANSFIFKYAETNNECHPCHPNCTQGCTGPRI 425          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4])

HSP 1 Score: 248.825 bits (634), Expect = 1.531e-66
Identity = 154/494 (31.17%), Postives = 251/494 (50.81%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK----VRTFL-KADETNSSLGKCHPCHPQC-NGCYGVDKNHC-------------IHCNNFKLPENENLTLFSCVESCPS-NYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            SQC    ++ ++        C +C        CV  CP       +F+ K  ETN+   +CHPCHP C  G    ++  C             +   N  L  N    +F  V  C     ++  G  +    +   L G   ++VI+A+                 + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   +ILG G FG VY G W  +             +  K+ V IK+LN S       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ +++ ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NH++ITDFGL+++++ ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   +I D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  530 SQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNN---ECHPCHPNCTQGSVACNRFRCRTRILYRTSCDNPMQSYNCSLDRNMFDAMFLNVTYCTGPRIQDCVGILDRTPLIAAGLIGGLFVIVIIALGVAVY------------IRRKSIKKKRALRRFLETELVEPLTPSGAAPNQAQLRILKETELKRV---KILGAGAFGMVYKGIWVPEG------------ETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYL 992          

HSP 2 Score: 195.667 bits (496), Expect = 5.854e-50
Identity = 160/613 (26.10%), Postives = 273/613 (44.54%), Query Frame = 2
Query:  206 YNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQ---CVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSIT 1984
            Y TL++    NC  V GN+ I +++   N     L FL  I+E+TG + +  +    +PL NLR+IRG ++LY  +   +L        D    +       + L++L  I++G +Y+  ++F      + W++++++P  + +          C K+C  +  +G CWG    QCQ  +K      C  RCF     +  CC+ +C GGC     + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +Q   C+PC  +C ++C   +       + +  ++D   ++K  NCT   G +              +   + D L     +R I+G  +++++  P  +  L   SNL  I         SL I+    I+ L  +SL+ I    ++  NN++LC++    + ++ +T T     +I +N   +P+ C +   +C   C S+ GCWGPGP+ C+SC     G  C ++C +  G +    + S VC++C  +C K      TC G   D C+  C H  +   CV +C         F+ K  +T   C PCH +C   S+ 
Sbjct:   19 YKTLRK-FYENCEVVMGNLEITSIERNRN-----LSFLKSIREVTGYVLVALNQFDYLPLENLRIIRG-TKLY--EGRYSLAIFLNYRRDGYFGLRQ-----LGLKNLTEILNGGVYVDQNKFLCHADTIHWHDIIKNPRSELLVVPSNNSGNTC-KRC-HRSCNGRCWGHQEDQCQSLTKTVCAEQCDGRCFGPYVSN--CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPCTDICPKVC---DGIGTGSLQMAQ-TVDSSNIEKFVNCTKINGNLIFLITGIKGDMFHGIRALDPDRLNVFRTVREITG--FLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQR--ALIKNN--REPRECSKEQKICDPLC-SEAGCWGPGPDQCLSCKYFSRGKTCVKSCNLYYGDVREFANGS-VCVECDSQCEKAGEKGLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQGSVA 600          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64])

HSP 1 Score: 248.825 bits (634), Expect = 1.800e-66
Identity = 173/583 (29.67%), Postives = 271/583 (46.48%), Query Frame = 2
Query: 2213 CSQCTIRTDQRISLSKTDWKG---CTQCKGYWFDDKCVSIC----PKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN----------YKETS------------GNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETY----------LSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIV------PEHVQRF 3817
            CSQ  +  D   S+S     G   C  CK +     CV  C      VR F           +C     +   C+G   +HC+ C + K   N       CVE CP            Y ET+            G +   I   + +     ++    +  +FV+  + +    F   +  K+KR   +   +   E  + + + PN   L ++    L+ +   +ILG G FG+VY G W  +             +  K+ V IK+LN S       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ +++ ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NH++ITDFGL++++  N+ E     G +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + Y          L  PN  + + +      ++     DE  Y  PHS N      I +     NQ           PE V RF
Sbjct:  495 CSQQRMVCDPLCSVSGCWGPGPNQCLSCKYFSRGRTCVRSCNLYNGDVREFANGSTCVECDSQCEKAEDKSLTCHGPGPDHCVKCLHLKDGPN-------CVEKCPDGLQGANSFIFKYPETNNECHPCHPNCTQGCTGPRIQDCIGILDRTPLIAAGVIGGMFVVVIVALGFAIFFRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KILGTGAFGTVYKGIWVPEG------------ETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNHSKFFQSLLDEEELDDLMDADE--YLVPHSLNAPPTSHIPHPHVDSNQNQFGYHDGSRCPEDVTRF 1052          

HSP 2 Score: 196.052 bits (497), Expect = 5.678e-50
Identity = 178/668 (26.65%), Postives = 284/668 (42.51%), Query Frame = 2
Query:   77 WIYLHILLISLIF----YRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSITRLPVCTGP 2008
            W    +LL  L+F     + S      P      S++  LD      Y TL++    NC  V GN+ I +++   N     L FL  I+E+TG + +  +    +PL NLR+IRG ++LY  +   +L        D    +       + LR+L  I++G +Y+  ++F      + W +++++P  + +          C ++C  +  +G CWGP   QCQ  +K      C  RCF     +  CC+ +C GGC     + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +    C+ C  +C ++C      S      S  ++D   ++K  NCT   G +              +   + + L     +R I+G  Y++++  P  +  LS  SNL  I         SL I+    I+ L  +SL+ I    ++  NN++LC++    + ++ +T T      I DN   DP+ C Q+  VC   C S  GCWGPGPN C+SC     G  C  +C +  G +    +    C++C  +C K      TC G   D C+  C H  +   CV +C         F+ K  +T   C PCH +C          CTGP
Sbjct:    2 WPVRFLLLFCLVFTFAVLQRSSGQSVCPGTDNKLSTLSDLD----QQYKTLRK-FYENCEVVMGNLEITSIERNRN-----LSFLKSIREVTGYVLVALNQFDYLPLENLRIIRG-TKLY--EGRYSLAIFLNYRRDGYFGLRQ-----LGLRNLTEILNGGVYVDQNKFLCHADTIHWQDIIKNPRSELLVVPSNNSGNTC-RRC-HRSCNGRCWGPQEDQCQSLTKTVCAEQCDGRCFGPYVSN--CCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKTEVEENNIKMCIQCTEICPKMCDGIGTGS----LQSAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDMYHGIRALDPERLNVFRTVREITG--YLNIQSWPENMTDLSVFSNLVTIGGRTLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQK--AKIKDN--RDPRECSQQRMVCDPLC-SVSGCWGPGPNQCLSCKYFSRGRTCVRSCNLYNGDVRE-FANGSTCVECDSQCEKAEDKSLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYPETNNECHPCHPNCTQG-------CTGP 627          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234])

HSP 1 Score: 265.774 bits (678), Expect = 2.776e-72
Identity = 154/481 (32.02%), Postives = 243/481 (50.52%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK------VRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            SQC    D  ++        CT+C  +     CV  CP+         F  ADE      +CHPCHP C +GC     + C+  +   LP++    L +            S      I V + L+                            + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ I   +ILG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GVS   + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  378 SQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDK----ECHPCHPNCTDGCNNPTSHDCLWNDPLTLPQHARTPLIA-----------ASVIGGLFIIVIMALT------------------------FAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 803          

HSP 2 Score: 150.214 bits (378), Expect = 7.072e-36
Identity = 128/454 (28.19%), Postives = 185/454 (40.75%), Query Frame = 2
Query:  662 KCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKIT---KTCEPCHKDC 1966
            +C K CM     G CWGP    CQ  +K      C  RC+ S   D  CC+ +C GGCT    + C +C    D+  C  +CP   I N      E N   +  +   C+NKCP   +  +  C   C   K E + +    C PC  +C ++C      S      S  ++D   + K  NCT   G +              +       L     +R I+G  +++++  P  +  LS  SNL  I   V     SL I+    ++ L  +SLK I    ++  +N  LCY+    + ++ +T   N  T I +N    P+ C   G VC   C S  GCWGPG N C+SC     G  C  +C +  G  +       VC+ C  +C K      TC G   D C   C +  +   CV +C         F+ K     K C PCH +C
Sbjct:    9 RCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGS----LQSAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNC 442          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234])

HSP 1 Score: 265.388 bits (677), Expect = 9.055e-72
Identity = 150/463 (32.40%), Postives = 241/463 (52.05%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSIC----PKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSG-----NSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C  C+ +     CV  C     + R F+          +C         CYG   +HC  C+NFK   N       CVE CP   +  +         +  C F  + G    L+  +V+    +  +  +     + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ I   +ILG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GVS   + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  525 CLSCRYFSRGKSCVRSCNLYKGESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPN-------CVEKCPEGLQGANSFIFKYADEDKECFFSCVVGTLTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 964          

HSP 2 Score: 185.652 bits (470), Expect = 9.818e-47
Identity = 160/602 (26.58%), Postives = 249/602 (41.36%), Query Frame = 2
Query:  236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS-SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKITKTCEPCHKDCHSRSITRL 1990
            NC  V GN+ I +++   N     L FL  I+E+TG + +  +    +PL NLR+IRG   +  ++   AL        D +  +       + LR+L  I++G +Y+  ++F      + W +++  P    V      +  +C K CM     G CWGP    CQ  +K      C  RC+ S   D  CC+ +C GGCT    + C +C    D+  C  +CP   I N      E N   +  +   C+NKCP   +  +  C   C   K E + +    C PC  +C ++C      S    +    ++D   + K  NCT   G +              +       L     +R I+G  +++++  P  +  LS  SNL  I   V     SL I+    ++ L  +SLK I    ++  +N  LCY+    + ++ +T   N  T I +N    P+ C   G VC   C S  GCWGPG N C+SC     G  C  +C +  G  +       VC+ C  +C K      TC G   D C   C +  +   CV +C         F+ K     + C   C   ++T L
Sbjct:   63 NCEVVMGNLEITSIEPGRN-----LSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG---IKLYEDRYALAIFLNYRKDGNYGLRE-----LGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMSSNAECGRCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQSAQ----TVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECFFSCVVGTLTPL 631          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234])

HSP 1 Score: 265.388 bits (677), Expect = 1.034e-71
Identity = 154/481 (32.02%), Postives = 243/481 (50.52%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK------VRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            SQC    D  ++        CT+C  +     CV  CP+         F  ADE      +CHPCHP C +GC     + C+  +   LP++    L +            S      I V + L+                            + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ I   +ILG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GVS   + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  532 SQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDK----ECHPCHPNCTDGCNNPTSHDCLWNDPLTLPQHARTPLIA-----------ASVIGGLFIIVIMALT------------------------FAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 957          

HSP 2 Score: 189.889 bits (481), Expect = 4.736e-48
Identity = 163/597 (27.30%), Postives = 248/597 (41.54%), Query Frame = 2
Query:  236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS-SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKIT---KTCEPCHKDC 1966
            NC  V GN+ I +++   N     L FL  I+E+TG + +  +    +PL NLR+IRG   +  ++   AL        D +  +       + LR+L  I++G +Y+  ++F      + W +++  P    V         +C K CM     G CWGP    CQ  +K      C  RC+ S   D  CC+ +C GGCT    + C +C    D+  C  +CP   I N      E N   +  +   C+NKCP   +  +  C   C   K E + +    C PC  +C ++C      S      S  ++D   + K  NCT   G +              +       L     +R I+G  +++++  P  +  LS  SNL  I   V     SL I+    ++ L  +SLK I    ++  +N  LCY+    + ++ +T   N  T I +N    P+ C   G VC   C S  GCWGPG N C+SC     G  C  +C +  G  +       VC+ C  +C K      TC G   D C   C +  +   CV +C         F+ K     K C PCH +C
Sbjct:   37 NCEVVMGNLEITSIEPGRN-----LSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG---IKLYEDRYALAIFLNYRKDGNYGLRE-----LGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMSSG----RCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQ----SAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNC 596          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234])

HSP 1 Score: 265.003 bits (676), Expect = 1.044e-71
Identity = 154/481 (32.02%), Postives = 243/481 (50.52%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK------VRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            SQC    D  ++        CT+C  +     CV  CP+         F  ADE      +CHPCHP C +GC     + C+  +   LP++    L +            S      I V + L+                            + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ I   +ILG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GVS   + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  527 SQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDK----ECHPCHPNCTDGCNNPTSHDCLWNDPLTLPQHARTPLIA-----------ASVIGGLFIIVIMALT------------------------FAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 952          

HSP 2 Score: 189.889 bits (481), Expect = 5.163e-48
Identity = 163/597 (27.30%), Postives = 248/597 (41.54%), Query Frame = 2
Query:  236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS-SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKIT---KTCEPCHKDC 1966
            NC  V GN+ I +++   N     L FL  I+E+TG + +  +    +PL NLR+IRG   +  ++   AL        D +  +       + LR+L  I++G +Y+  ++F      + W +++  P    V         +C K CM     G CWGP    CQ  +K      C  RC+ S   D  CC+ +C GGCT    + C +C    D+  C  +CP   I N      E N   +  +   C+NKCP   +  +  C   C   K E + +    C PC  +C ++C      S      S  ++D   + K  NCT   G +              +       L     +R I+G  +++++  P  +  LS  SNL  I   V     SL I+    ++ L  +SLK I    ++  +N  LCY+    + ++ +T   N  T I +N    P+ C   G VC   C S  GCWGPG N C+SC     G  C  +C +  G  +       VC+ C  +C K      TC G   D C   C +  +   CV +C         F+ K     K C PCH +C
Sbjct:   32 NCEVVMGNLEITSIEPGRN-----LSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG---IKLYEDRYALAIFLNYRKDGNYGLRE-----LGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMSSG----RCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQ----SAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNC 591          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:100493234])

HSP 1 Score: 265.003 bits (676), Expect = 1.296e-71
Identity = 154/481 (32.02%), Postives = 243/481 (50.52%), Query Frame = 2
Query: 2216 SQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK------VRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            SQC    D  ++        CT+C  +     CV  CP+         F  ADE      +CHPCHP C +GC     + C+  +   LP++    L +            S      I V + L+                            + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ I   +ILG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GVS   + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP +C++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  531 SQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDK----ECHPCHPNCTDGCNNPTSHDCLWNDPLTLPQHARTPLIA-----------ASVIGGLFIIVIMALT------------------------FAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 956          

HSP 2 Score: 189.119 bits (479), Expect = 8.841e-48
Identity = 162/597 (27.14%), Postives = 248/597 (41.54%), Query Frame = 2
Query:  236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS-SQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTII-NTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVRECSR-----THFLNKIT---KTCEPCHKDC 1966
            NC  V GN+ I +++   N     L FL  I+E+TG + +  +    +PL NLR+IRG   +  ++   AL        D +  +       + LR+L  I++G +Y+  ++F      + W +++  P    V         +C K CM     G CWGP    CQ  +K      C  RC+ S   D  CC+ +C GGCT    + C +C    D+  C  +CP   I N      E N   +  +   C+NKCP   +  +  C   C   K E + +    C PC  +C ++C      S    +    ++D   + K  NCT   G +              +       L     +R I+G  +++++  P  +  LS  SNL  I   V     SL I+    ++ L  +SLK I    ++  +N  LCY+    + ++ +T   N  T I +N    P+ C   G VC   C S  GCWGPG N C+SC     G  C  +C +  G  +       VC+ C  +C K      TC G   D C   C +  +   CV +C         F+ K     K C PCH +C
Sbjct:   36 NCEVVMGNLEITSIEPGRN-----LSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG---IKLYEDRYALAIFLNYRKDGNYGLRE-----LGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMSSG----RCPKSCM-----GRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSD--CCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQSAQ----TVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTVREITG--FLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTS--NQRTTIREN--KKPENCTAEGMVCDPLC-SNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGE-SREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCT-KCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNC 595          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771])

HSP 1 Score: 259.225 bits (661), Expect = 7.266e-70
Identity = 151/489 (30.88%), Postives = 244/489 (49.90%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C +  SQC    D  ++        CT+C  +     CV  CP          F  AD+      +CHPCHP C  GC G   + CI+     +  LP++    L +                   + + V ++                      +     + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   ++LG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  552 CVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-------------AGVIGGLFILVIMA----------------------LTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985          

HSP 2 Score: 196.438 bits (498), Expect = 3.210e-50
Identity = 163/597 (27.30%), Postives = 260/597 (43.55%), Query Frame = 2
Query:  236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
            NC  V GN+ I +++        DL FL  I+E+TG + +  +    +PL NLR+IRG ++LY  +   AL        D +  +       + L++L  I++G +Y+  ++F      + W +++ +P   ++T   T   + C +    K  +G CWGP  + CQ  ++      C  RC+     D  CC+ +C GGC+    + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +    C PC  +C + C      S      S  ++D   + K  NCT   G +              +   + + L     +R I+G  +++++  P  +   S  SNL  I   V     SL I+    I+ L  +SLK I    I+  +N+ LCY+    +  +    T+N   +I DN  A+   C   G VC+  C S  GCWGPGP+ C+SC     G IC E+C +  G     ++ S +C++C  +C K      TC G   D C   C H  +   CV +C         F+ K     + C PCH +C
Sbjct:   55 NCEVVMGNLEITSIEHNR-----DLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRRAEN--CTAEGMVCNHLC-SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGS-ICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNC 621          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771])

HSP 1 Score: 259.225 bits (661), Expect = 7.562e-70
Identity = 151/489 (30.88%), Postives = 244/489 (49.90%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C +  SQC    D  ++        CT+C  +     CV  CP          F  AD+      +CHPCHP C  GC G   + CI+     +  LP++    L +                   + + V ++                      +     + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   ++LG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  552 CVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-------------AGVIGGLFILVIMA----------------------LTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985          

HSP 2 Score: 196.823 bits (499), Expect = 2.418e-50
Identity = 163/597 (27.30%), Postives = 260/597 (43.55%), Query Frame = 2
Query:  236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
            NC  V GN+ I +++        DL FL  I+E+TG + +  +    +PL NLR+IRG ++LY  +   AL        D +  +       + L++L  I++G +Y+  ++F      + W +++ +P   ++T   T   + C +    K  +G CWGP  + CQ  ++      C  RC+     D  CC+ +C GGC+    + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +    C PC  +C + C      S      S  ++D   + K  NCT   G +              +   + + L     +R I+G  +++++  P  +   S  SNL  I   V     SL I+    I+ L  +SLK I    I+  +N+ LCY+    +  +    T+N   +I DN  A+   C   G VC+  C S  GCWGPGP+ C+SC     G IC E+C +  G     ++ S +C++C  +C K      TC G   D C   C H  +   CV +C         F+ K     + C PCH +C
Sbjct:   55 NCEVVMGNLEITSIEHNR-----DLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRRAEN--CTAEGMVCNHLC-SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGS-ICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNC 621          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Egfr (epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294])

HSP 1 Score: 247.284 bits (630), Expect = 3.557e-66
Identity = 158/552 (28.62%), Postives = 268/552 (48.55%), Query Frame = 2
Query: 2270 KGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHP-CHPQCNG--CYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN---------YKETSGNSNENICVF---------------VFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYT-----TNTFNNYIEIKQHEDEI---SYHAPH-----SPNQNRVRVIGNMRPRGNQKSI 3790
            + C  C+      +CV  C  +    +    NS   +CHP C PQ     C G   ++CI C ++       +    CV++CP+          +K    N+  ++C                 V+ SG ++  +   +V   +   +  +     + R+   ++  L+         +  TPS   PN  HL ++     + I   ++LG G FG+VY G W            +   +  K+ V IK L  +       E +DE  +MASV + H  RL+G+    + +L I+  MP G +  Y+ ++K ++  + LL W  QIA GM YLE+  ++HRDLA RNVL+    HV+ITDFGL+K++   + E    GG VP++W+A+E++   IY+H++DVW+Y VT+WE+ TF + PY+ + A +I   + KG RL QP IC++D+Y++M+KCW +D + RP F  L  EF   + + + YL     E+ +      +N +   ++ +  ED +    Y  P      SP+ +R  ++ ++    N  ++
Sbjct:  521 RDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY-------IDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKI---KVLGSGAFGTVYKGLW------------IPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQL-ITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSATSNNSTV 1049          

HSP 2 Score: 197.593 bits (501), Expect = 1.406e-50
Identity = 162/574 (28.22%), Postives = 265/574 (46.17%), Query Frame = 2
Query:  221 QDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQ-FCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK-----TCSGLRSDQCIGGCKHAMENSMCVREC 1906
            Q + NNC  V GN+ I  V+        DL FL  I+E+ G + I  + +  +PL NL++IRG++ LY        +N++ ++I  +   + +    + +R+L+ I+ G +  S+     ++  ++W +++++    +++      P+ C K C     +G CWG     CQ  +K    + C++RC      D  CC++QC  GCT    S C+ CQ   D   C+  CPP  + N  T   + N   +  F   C+ KCP   ++   G C   C    YE + D   +C  C   C ++C    I    +FK +  S++   +K    CT   G + I   +F        P  +  +L+ L+ ++ I+G  ++ ++  P     L    NL+ I          SL ++  +I+ LGL+SLK I +  +    N  LCY +   +K +  T   N  T I +N     K C+   +VC+  C S+ GCWGP P  C+SC NV  G  C E C +  G        S+ C++CH EC       TC+G   D CI  C H ++   CV+ C
Sbjct:   52 QRMYNNCEVVLGNLEITYVQRNY-----DLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNA-LY--------ENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPK-CDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSD--CCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGI---GEFKDT-LSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITG--FLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTP--NQKTKIMNNRAE--KDCKAVNHVCNPLCSSE-GCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSE-CIQCHPECLPQAMNITCTGRGPDNCI-QCAHYIDGPHCVKTC 595          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:95410])

HSP 1 Score: 236.884 bits (603), Expect = 7.520e-63
Identity = 151/494 (30.57%), Postives = 241/494 (48.79%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNG------CYGVDKNHCIHCNNF------------------------KLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAY-----FSNANESDSQTPSP--PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVL--NHSCDQN-EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN 3637
            C  C  +    +CV  C +V   L  +        C PCHP+C        CYG + + C  C ++                        K P+ E +      + CP N   +  + +E  C        E     +  +   V+  L  +I    +    KR+R K++ Y            +  TPS   PN   + ++    L  +   ++LG G FG+VY G W  D             ++ K+ V IKVL  N S   N E +DE  +MA V   +  RL+G+    + +L ++  MP G +  ++ +++  L  + LL W  QIA GM YLE   ++HRDLA RNVL+   NHV+ITDFGL+++++ ++ E    GG VP++W+A+E++    ++H++DVW+Y VT+WE+ TF   PY+ + A EI D + KG RL QP IC++D+Y++M+KCW +D E RP F  L +EF   + + + ++   N
Sbjct:  529 CVNCSQFLRGQECVEEC-RVWKGLPREYVRGK--HCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGI-----CQPCPINCTHSCVDLDERGCP------AEQRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKL---KVLGSGAFGTVYKGIWIPDG------------ENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL-VTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN 992          

HSP 2 Score: 162.925 bits (411), Expect = 8.623e-40
Identity = 155/594 (26.09%), Postives = 246/594 (41.41%), Query Frame = 2
Query:  182 LDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTV--IDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETG-DEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQE-GECKTQCTFRKYERQGD----QCVPCKILCEQIC---TLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES-LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVREC 1906
            L  S  ++ + L+  L   C  V GN+ +  + + ++     L FL  I+E+ G + I ++ +  VPL+ LR++RG        ++  L N   +      +   + + +  + LRSL  I+ G + I  + Q C     V W ++L    + +     T +   C   C    K   CWG     CQI +     +C + C   +     +CC+ QC  GCT    S C+AC     + +C+  CP     N +T     N   R  F   C+  CP   L  E G C   C     E   +    +C  C   C  +C    +E +           ++    +++ A C    G +    ESF  +    V     + L+  E L  I+G +YI     P     LS   NL+ I   ++   + SLT+    I  LGL+SL+ + +       NT LC+ +   +  + +    N    +  +G    + C   G VC+  C ++  CWGPGP  C++C+    G  C E C V  G L       K CL CH EC     ++TC G  +DQC   C H  ++S CV  C
Sbjct:   35 LPASPETHLDMLRH-LYQGCQVVQGNLELTYLPANAS-----LSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQ-DMVLWKDVLRKNNQLAPVDMDTNRSRAC-PPCAPTCKDNHCWGESPEDCQILTGT---ICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCYGLGMEHLRGAR-------AITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISA--WPESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFR----NPHQALLHSGNRPEEACGLEGLVCNSLC-ARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKG-LPREYVRGKHCLPCHPECQPQNSSETCYGSEADQC-EACAHYKDSSSCVARC 601          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Match: Erbb3 (erb-b2 receptor tyrosine kinase 3 [Source:MGI Symbol;Acc:MGI:95411])

HSP 1 Score: 223.016 bits (567), Expect = 2.387e-58
Identity = 101/277 (36.46%), Postives = 167/277 (60.29%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFM---DEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            ++LG G FG+V+ G W            +   +  K+ V IKV+     +  F    D +  + S+ H H +RL+G+   GS   L++ Y+PLGS+  ++ +++++L  ++LL W  QIA GM YLE + ++HRDLA RNV++   + VQ+ DFG++ ++ P+  ++       P++W+A+E++  G Y+H++DVW+Y VT+WE+ TF   PY  L+  EI D + KG RL QP IC++D+Y++M+KCW +D   RP F+ L  EF   + +   YL
Sbjct:  711 KVLGSGVFGTVHKGIW------------IPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYL 974          

HSP 2 Score: 199.519 bits (506), Expect = 4.431e-51
Identity = 169/621 (27.21%), Postives = 264/621 (42.51%), Query Frame = 2
Query:  182 LDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSVT----GKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAI--ESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNK--------ITKTCEPCHKDC 1966
            + G   + Y TL + L   C  V GN+ I        G   DL FL  I+E+TG + +  +  S +PL NLRV+RG      +D   A+     V ++ + + S++++  +    L  I+ G +YI  + + C  +  ++W +++  P  + V     G C P    C + C      G CWGP    CQI +K  C  + C  RCF       +CC+ +C GGC+    + C AC+   D+  C P CP   + N+ T   EPN + +  +  +C+  CP   +  +  C   C   K E   +    C PC+ LC + C      S       Y ++D   +    NCT   G +              +P  + + L     +R I+G  Y++++  P  + + S  SNL  I   SL     + L + N +++ LG +SLK I    ++   N +LCY     +  +++      + I  +  + +   C   G VC   C S  GCWGPGP  C+SC N     +C  +C V  G        +  C  CH EC       TC+G  SD C   C H  +   CV  C       K            C PCH++C
Sbjct:   38 VTGDADNQYQTLYK-LYEKCEVVMGNLEI-----VLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQ---VYDGKFAI----FVMLNYNTNSSHALRQ-LRFTQLTEILLGGVYIEKNDKLCH-MDTIDWRDIVRVPDAEIVVKNNGGNCPP----CHEVC-----KGRCWGPGPEDCQILTKTICAPQ-CNGRCF--GPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEGTGSGS------RYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITG--YLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGE---CVAEGKVCDPLCSSG-GCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAH-CFSCHPECQPMEGTSTCNGSGSDAC-ARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENC 617          
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|P04412|EGFR_DROME (Epidermal growth factor receptor OS=Drosophila melanogaster OX=7227 GN=Egfr PE=1 SV=3)

HSP 1 Score: 476.478 bits (1225), Expect = 4.575e-143
Identity = 352/1217 (28.92%), Postives = 569/1217 (46.75%), Query Frame = 2
Query:  140 EYPEIKYCFSSMDLLD--GSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQD---ISVSNSIKTVIDLRSLRSIVSGNIYISSQF-CSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHR---------PEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES--LVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-DSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCY--QNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADE-TNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKL-PENE-----NLTLFSCVESCP-----SNYKETSGN--------------SNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLAR-KGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYP 3634
            E+ + K C  +   L    ++  +Y  L+ D   NCT+V GN+ +  + +E+     DL FL  I+E+TG + I + ++  V    L++IRG             +  F +S++++   + V+ S    +++  LR +++G +   + +    +  ++W+E++ + T        T    +C K C +    G CWG     CQ FSK  C  +    RC+  +    ECC+  C GGCT      CIAC+   D  V + ECPP +  N  T + E N   +  +   C+ +CP  LL   G C   C   K ++ G +CVPC   C + C    +    +            +    NCT   G ++I  ++F   +         P  +P+ + +  +    ++ I+G  Y++++    +  +LS+  NL+ I    L+  +  +L I+ + +  L +++LK I + ++  ++N  LCY    ++  I K         +++N  AD  LCE+ G +CS QC+   GCWG G + C++C N      C  +C    GY++N     ++ C  CH EC +TC+G  +D C   C H  +   CV EC +  + ++    C  CH  C          CTGP +T G G C  C   I+  D  V+RC    +   +GYF                 +      +   CH LC  CT              + C++C  Y   ++C + CP       AD  T+    +C   HP+CNGC G   + C  C NFKL   NE     N T+F+C   CP      NY+ T+                +N ++ +   ++G            L     +  ++T  C  + K K++  K+    S   +S+   PS    N   +    + E   GG +LG G FG VY G W  +             ++ K+ V IK L  S       EF+ E  IMAS  H + L+L+ V    S+ +LI+  MPLG +  Y+  N+  +  K LL W+ QIA GM YLE   ++HRDLA RNVL+   + V+ITDFGL+K+++ + +E +  GG +P++WLA+E +R+ +++ K+DVWA+ VT+WE+ TF   P+E + A +I D I  G +L QP+ICSLDIY  +L CW +D   RP F+ L T F  ++ +   YL+ P
Sbjct:   95 EFVKGKICIGTKSRLSVPSNKEHHYRNLR-DRYTNCTYVDGNLKLTWLPNENL----DLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRG-------------RTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPK-CHESCTHG-CWGEGPKNCQKFSKLTCSPQCAGGRCYGPKP--RECCHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDK-GGECVPCNGPCPKTCPGVTVLHAGN------------IDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPL-DPERREVFSTVKEITG--YLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEP--EQKVWVNENLRAD--LCEKNGTICSDQCNED-GCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAYKFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKYNDR--GVCRECHATCDG--------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGR-----AVCRKCHPLCELCTNYGYHE--------QVCSKCTHYKRREQCETECP-------ADHYTDEEQRECFQRHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITG----------AVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGG-VLGMGAFGRVYKGVWVPEG------------ENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMS-SQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIP 1208          
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|P0CY46|EGFR_APIME (Epidermal growth factor receptor OS=Apis mellifera OX=7460 GN=Egfr PE=2 SV=1)

HSP 1 Score: 466.463 bits (1199), Expect = 1.811e-140
Identity = 335/1047 (32.00%), Postives = 499/1047 (47.66%), Query Frame = 2
Query:  581 LANVEWNELLEDPTRQ--------SVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICT-LEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTE-SFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAI--ESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQ--NTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENE----NLTLFSCVESCPSNYKETSGNSN-ENICVFV---FLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSP----PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLS 3628
            +  + W E++  P+          S    CTP    C K C Q      CWG     CQ +SK  C  +    RCF       ECC+  C GGCT    S CIAC+   D+ VC  ECPP +  N  T   EPN   +  +   C+ +CPE LL+  G C   C  +K    G +CVPC   C + C  +E++ S N   +   ++    +  L    +F+GF  +    SF K   ++ P    D L+    L+ I+G + I      FK  +LS+  NL+ I   +L    + SL ++ T +   GL SLK I + +I    N  LCY     +  I K+      +++S+N   +   C + G VC  QC  + GCWGPGP  C+SC N  LG  C ++C   PG     + T KV   CH+EC  +C G  +D C   CKHA +   CV EC  + + +     C+ CH +C       +  C GP N  GP GC+ C   IL  D+  E C Q   +  +GY+          P      K      +   CH  C +CT                C +C  Y   ++C   CP       AD    +   C PC  +C GC+G   N C  C N+K+  +E    N T F+C E+C   Y     N + E  C       +       ++  V    + F +   I  +    + K K + +K   +     D++   P    PN+  L +I  + +     G ILG G FG+VY G W  +             ++ K+ V IKVL+     N   EF+DE  IMASV H + L+L+ V    S+ +L++  MPLG +  ++ + K  +  K LL W  QIA GM YLE   ++HRDLA RNVL+   N V+ITDFGL+K+++ N+++ +  GG +P++WLA+E ++  +++HK+DVWA+ VT+WE+ T+   PYE + A  + + + KG RL QP IC++D+Y++M+KCW +D E RP+F+ L  +F   S +   YL+
Sbjct:   10 IRTINWEEIITGPSAMYSYVYNFTSPERACTP----CDKSCEQG-----CWGEGPENCQKYSKTNCSPQCWQGRCF--GPNPRECCHLFCAGGCTGPKQSDCIACKNFFDDGVCTQECPPMQKYNPTTYSWEPNPDGKYAYGATCVRRCPEHLLKDNGACVRSCPPKKKALNG-ECVPCDGPCPKTCKGVEKVHSGNIDSFKDCTIIEGSITILDQ--SFQGFQHVYRNFSFGKRYEKMHP----DKLEVFSTLKEITGFLNIQGDHKDFK--NLSYFRNLEVIGGRTLTEYFA-SLYVVKTSLVSFGLSSLKKIYSGSIAILENKNLCYAQSINWTRIKKSSEHE--SLLSNN--RNESECIKDGLVCDEQCSDE-GCWGPGPAQCLSCKNFILGNDCLQDCTA-PGIYQADEKTCKV---CHEECDGSCIGPNTDHC-KKCKHARDGPFCVPECPASKYND--NGVCKSCHGNC-------VGGCEGPENNIGPNGCHSCDKAIL-NDHVPEGCLQKKESCPDGYYYEWVSPLEQGPLKPLASK-----AVCRKCHSRCKKCTGYGFHE--------HVCQECTKYKRGEQCEDECP-------ADYFADANKLCIPCFSECRGCFGPGPNQCYKCRNYKIYIDEDTDGNTTSFNCTETCTPEYPHKIFNPDSEPYCSLETAGLIENELQPAILAGVAVFALAFLVVAAIIMYFWRVRAKAKENTVKMTMALTGLDDNEPLRPTGVKPNLAKLRIIKEEEMR---KGGILGYGAFGNVYKGVWVPEG------------ENVKIPVAIKVLHDGTGANTSKEFLDEAYIMASVEHPNLLQLLAVCMT-SQMMLVTQLMPLGCLLDFVRRFKDKIGSKALLNWCTQIARGMAYLEERRLVHRDLAARNVLVQTPNCVKITDFGLAKLLDINEEQYKAAGGKMPIKWLALECIQHRVFTHKSDVWAFGVTIWEVLTYGGRPYENVPARNVPELLEKGERLPQPAICTIDVYMIMIKCWMLDAESRPSFKELAEDFAKMSRDPGRYLA 979          

HSP 2 Score: 61.2326 bits (147), Expect = 7.769e-8
Identity = 64/247 (25.91%), Postives = 99/247 (40.08%), Query Frame = 2
Query:  245 HVYGNIFINNVKSESNGSEPD-LEFLSGIKEITGSLKIRNS-----NISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSV------TGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCF-------LSETGDEEC--CNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKK 916
            HVY N        + +   PD LE  S +KEITG L I+       N+S    RNL VI G +      S+  ++ S                    L SL+ I SG+I I  +   C +  ++ W  + +    +S+        +C      C ++C  +G    CWGP  +QC     C+  +  N C        + +  ++ C  C+ +C G C   ++  C  C+   D   C PECP  K
Sbjct:  220 HVYRNFSFGKRYEKMH---PDKLEVFSTLKEITGFLNIQGDHKDFKNLSY--FRNLEVIGGRTLTEYFASLYVVKTSL---------------VSFGLSSLKKIYSGSIAILENKNLCYA-QSINWTRIKKSSEHESLLSNNRNESECIKDGLVCDEQCSDEG----CWGPGPAQCL---SCKNFILGNDCLQDCTAPGIYQADEKTCKVCHEECDGSCIGPNTDHCKKCKHARDGPFCVPECPASK 438          
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|P24348|LET23_CAEEL (Receptor tyrosine-protein kinase let-23 OS=Caenorhabditis elegans OX=6239 GN=let-23 PE=1 SV=3)

HSP 1 Score: 407.142 bits (1045), Expect = 6.956e-119
Identity = 393/1388 (28.31%), Postives = 610/1388 (43.95%), Query Frame = 2
Query:   86 LHILLISLIFYRYSDSLIEYPEIKYCFSSMDLL-----DGSQSSNYNTLKQDLGN---NCTHVYGNIFINNVKS-------ESNGSEPD----------LEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISS--QFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGF---------CWGPLTSQCQ-IFSKCRKRMCANRCFLS-ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCT-FRKYERQGD--QCVPCK-ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHA------MENSM-CVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDK-----CVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTP----SPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ-NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--------VEQNYTT----NTFNNYIEIKQHEDE-------------ISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEP 3991
            L I+ I L F+  S++ +     K C S  D L     +G        + +DL      C  VYGN+ I  +++       ES  S  D          + F   ++EI GSL I  +NI  +    LRVI GD     HD+  AL           I  ++ +  V+ +R LR I +G++ I    + C     ++W ELL DP  Q V      + T   + C Q GKS           CWG   + CQ ++     + C+ +CF S  T   ECC+S CLGGCT     +CIAC     + +C   CP +KI N +TG    N   R    N C+ +CP  LL +   C   C+    Y+   D  +C  C+   C +ICT++              L    LK L  C       QID    ++H          + LK LE ++ +S   YI +    F    L FL NLQ IE   +  +  +L I    D+  L L SLK+IK  A+    N +LCY     + +I+ +   ++   ++     D KLCE    VC   C+ + GCWG  P  C+ C   +    C E C  + G+L N   TS  C +C  EC +TC+GL    C+  C+H         N M CV +C  +HF  +    CE CH  C+         CTGP +  G GGC +C+  +   +  +  C Q++ +N           +   + +I  +    VI       C +C+I      S  +   +    CK   +        C+  CP V +F+  D  N+   KCH    Q   C       C  C NF + + +   +  CV  CP N   ++  + E  C+   ++  +    ++ +  +   F +  +   F L    + +R   K   +   +    TP      PNM+ + +I S  L+  +  + LG G FG+V+AG +                K+ K+ V IKV      Q +E ++E   M  +RH + L++IG         +++ Y PLG+++ +L+ +K++L  +  + +  QIA+GM YLE   ++HRDLATRNVL+ K NHV+ITDFGLSKI+  + D + I  G V ++WLAIE      Y+H +DVWA+ VT WEI TF   PY+ +    I + +  G RL QP  CS D+Y  +L+CW  DP+ RP FE L+  FK +    + +L   N         E+ + T      F+  I+ + + D+              ++  PH    NR++ + + R +                  P  + +    V ++  +N       + SNG     D++++P+ +PSS +  Y EP
Sbjct:   11 LLIIPIFLTFFGNSNAQL----WKRCVSPQDCLCSGTTNGISRYGTGNILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF--HDN--ALY----------IHKNDKVHEVV-MRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKV------ETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG------------HLTNETLKNLEGCE------QIDGHLIIEH------AFTYEQLKVLETVKIVSE--YITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKR-GCWGKEPEDCLECKTWKSVGTCVEKCDTK-GFLRN--QTSMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQ-KNVCEKCHPTCYDNG------CTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNN------VCVENDLPNYYISTYDTEGVI----ETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCP-VNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGD---IAQCVSECPKNLPFSNPANGE--CLDYDIASRQRKTRMVIIGSVLFGFAVMFL---FILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRA-----------KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNG-----DYYNQPN-TPSSSSGYYNEP 1293          
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|Q62956|ERBB4_RAT (Receptor tyrosine-protein kinase erbB-4 OS=Rattus norvegicus OX=10116 GN=Erbb4 PE=1 SV=3)

HSP 1 Score: 264.618 bits (675), Expect = 9.407e-71
Identity = 154/489 (31.49%), Postives = 246/489 (50.31%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVR------TFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C +  SQC    D  ++        CT+C  +     CV  CP V        F  AD+      +CHPCHP C  GC G   + CI+     +  LP++    L +                   + + V ++                      +     + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   ++LG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMASV H H +RL+GV    + +L ++  MP G + +Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+YI+M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  552 CVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDVLQGANSFIFKYADQDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-------------AGVIGGLFILVIMA----------------------LTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYIVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985          

HSP 2 Score: 196.052 bits (497), Expect = 3.664e-49
Identity = 163/597 (27.30%), Postives = 260/597 (43.55%), Query Frame = 2
Query:  236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
            NC  V GN+ I +++        DL FL  I+E+TG + +  +    +PL NLR+IRG ++LY  +   AL        D +  +       + L++L  I++G +Y+  ++F      + W +++ +P   ++T   T   + C +    K  +G CWGP  + CQ  ++      C  RC+     D  CC+ +C GGC+    + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +    C PC  +C + C      S      S  ++D   + K  NCT   G +              +   + + L     +R I+G  +++++  P  +   S  SNL  I   V     SL I+    I+ L  +SLK I    I+  +N+ LCY+    +  +    T+N   +I DN  A+   C   G VC+  C S  GCWGPGP+ C+SC     G IC E+C +  G     ++ S +C++C  +C K      TC G   D C   C H  +   CV +C         F+ K     + C PCH +C
Sbjct:   55 NCEVVMGNLEITSIEHNR-----DLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTIGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITG--FLNIQTWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TVNQRIVIRDNRRAEN--CTAEGMVCNHLC-SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGS-ICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDVLQGANSFIFKYADQDRECHPCHPNC 621          
BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Match: sp|Q61527|ERBB4_MOUSE (Receptor tyrosine-protein kinase erbB-4 OS=Mus musculus OX=10090 GN=Erbb4 PE=1 SV=5)

HSP 1 Score: 259.225 bits (661), Expect = 5.082e-69
Identity = 151/489 (30.88%), Postives = 244/489 (49.90%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICP------KVRTFLKADETNSSLGKCHPCHPQC-NGCYGVDKNHCIH---CNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C +  SQC    D  ++        CT+C  +     CV  CP          F  AD+      +CHPCHP C  GC G   + CI+     +  LP++    L +                   + + V ++                      +     + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   ++LG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL++++  ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  552 CVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDR----ECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIA-------------AGVIGGLFILVIMA----------------------LTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KVLGSGAFGTVYKGIWVPEG------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985          

HSP 2 Score: 196.438 bits (498), Expect = 2.245e-49
Identity = 163/597 (27.30%), Postives = 260/597 (43.55%), Query Frame = 2
Query:  236 NCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKIT---KTCEPCHKDC 1966
            NC  V GN+ I +++        DL FL  I+E+TG + +  +    +PL NLR+IRG ++LY  +   AL        D +  +       + L++L  I++G +Y+  ++F      + W +++ +P   ++T   T   + C +    K  +G CWGP  + CQ  ++      C  RC+     D  CC+ +C GGC+    + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + +    C PC  +C + C      S      S  ++D   + K  NCT   G +              +   + + L     +R I+G  +++++  P  +   S  SNL  I   V     SL I+    I+ L  +SLK I    I+  +N+ LCY+    +  +    T+N   +I DN  A+   C   G VC+  C S  GCWGPGP+ C+SC     G IC E+C +  G     ++ S +C++C  +C K      TC G   D C   C H  +   CV +C         F+ K     + C PCH +C
Sbjct:   55 NCEVVMGNLEITSIEHNR-----DLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLY--EDRYALAIFLNYRKDGNFGLQE-----LGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGR--CHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSD--CCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGS----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITG--FLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFS--TINQRIVIRDNRRAEN--CTAEGMVCNHLC-SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGS-ICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNC 621          
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: A0A1B1ACY3 (Receptor protein-tyrosine kinase (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 2530.36 bits (6557), Expect = 0.000e+0
Identity = 1284/1292 (99.38%), Postives = 1284/1292 (99.38%), Query Frame = 2
Query:  131 SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
            SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLT FSCVESCPSNYKETSGNSNENICVFVFLSGLELILVILAVV  FVL TLF IITKFC ARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI
Sbjct:   53 SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTSFSCVESCPSNYKETSGNSNENICVFVFLSGLELILVILAVVLFFVLCTLFTIITKFCHARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 1344          
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: F6KBQ5 (Epidermal growth factor receptor 1 (Fragment) OS=Schmidtea mediterranea OX=79327 GN=egfr-1 PE=2 SV=1)

HSP 1 Score: 825.469 bits (2131), Expect = 0.000e+0
Identity = 396/398 (99.50%), Postives = 397/398 (99.75%), Query Frame = 2
Query: 2813 GKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
            GKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNS TYLSYPNVEQNYTTNTFNNYIEIKQHEDEIS+HAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI
Sbjct:    1 GKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSGTYLSYPNVEQNYTTNTFNNYIEIKQHEDEISHHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 398          
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: A0A0X3PH98 (Receptor protein-tyrosine kinase OS=Schistocephalus solidus OX=70667 GN=TR102389 PE=4 SV=1)

HSP 1 Score: 599.742 bits (1545), Expect = 0.000e+0
Identity = 413/1324 (31.19%), Postives = 632/1324 (47.73%), Query Frame = 2
Query:   77 WIYLHILL-ISLIFYRYSDSLIEYPEIKYCFSS----MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSV----------TGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKI-LCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP---IISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-------------------------------------------DSTSKV-----CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDC-HSRSITRLPV----CTGPSNTPGPGGCNKCQSMILRRDYQVER--CYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILE-----PCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLG----------KCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICV----FVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKF-----CLARKGKRK--RDKLKAYFSNANESDSQTPSP---PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ---------------------------------NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINP-NKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            +++L +LL      +R+S +  EYP IK C S        LD +    Y   +    + CTH+ GN+ + N++   NGS+PDL FL+ I E++G + I N+++  +PL +LR+IRG    Y    + +L NS  V      + +  ++ V+DLR L  I + N+ +  + Q C     V+++ L  +P +Q               C    T C   C+Q   + +CWGP   QCQ+ SKC     +  C +        C+  C+GGCT   SS+C AC+  L+N  C   CPPK I++  T   E N  F+    +IC+  CP   L+ +  C  +C F+        C PC    C + CT E+IF  N     +  +     +K+  C  + G + ++  +F K      P++  DDL  L NLR I G +Y+D   +P +L +L+FL NL  + +       +  +L+I N +++ +LG KSL+ +   A      + LCY  +   K I+   T           +  P  C+  G+VC  +C    GCWGPGP  C  C   + G +C  +CL +PG+ T P                                           ++ S+V     C +CH ECA+TC    +  CIG CKH  E + CV  CSR ++ ++ TK C  CH  C ++   T LPV    C+GP +  G GGC  C    +R++ + +R  C        ++      +        +         L+     PCH LC  C            T    C +C+G+ +  +CV  CP   T++  +  N++L           +C  CH QC  GCY      C++C   K+  +E    F C  +CP +   T  N+  N+C+    +  +SG         ++    L    + +        C   K KR+  R+ LK+ ++N    D ++ +    PNM  L +I+SD+L+F      LG G FG+VY GKW++        +  N  + + +DV +KV+    +                                  NE + E ++MASV H +CL LIGV    + + ++S+++ LGS+++YL +NK SL    LL WAEQIA+GM YLE   IIHRDLA RNVL+    HVQITDFGL+K+++  +++ + +  G VP+RWLAIETL+ GIYSHKTDVW+Y VTLWEIFTF   PYE ++  +I+D ++KG RL QPDIC+LD Y++M+KCW  D + RP F  L   F ++      YL
Sbjct:    7 YLFLALLLSTGGKSFRFSLT-PEYPNIKICRSRNVDCKTSLDPNIQLRYYRRQY---SECTHILGNLVLCNLRRYDNGSDPDLSFLTSIVEVSGYVYISNNDVRRIPLTSLRIIRGMVPYY----IPSLGNSALVISRNAFNKTVGLE-VLDLRKLTVIQNHNVALWDNPQLCYIAFRVDFHALFPNPKQQEALRVSNSDLISQSGCDFDNTSCHPSCVQTDTNAYCWGPEKDQCQLRSKCLHDT-SRYCLMDGYNLGTTCDDACIGGCTG-HSSNCWACRDKLNNRTCTGSCPPKYILSHVTSRQELNPEFKYDLHDICVKTCPAPFLKMDTVCVIECDFKTTIPINGSCEPCATSPCAEHCTKEQIFGTN-----FPLITSAAAEKMKTCEYYSGPIYLNRMAFEKRGSGPAPLARLDDLWNLRNLREIVGYIYLDFTGSPPELTNLTFLQNLYKVTAEFSDGVSLGIALSIYNASNLEFLGFKSLRYVDTDAYLEFLPS-LCY--LSGLKQILPMRT---------KAVKSPTTCDNEGHVCHSECLPITGCWGPGPAMCAHCCGFQAGDVCVSSCLDEPGFYTPPGLETQLVSVGASGSPFSSLQNAANIQCPTLPLTAAQLATMTAEEAISRVIPSPACARCHVECAQTCFNASNIACIGPCKHYKEANACVSNCSRNYYADETTKDCLLCHPTCSNALQSTPLPVSVAACSGPGSYLGNGGCTFCH--FIRKNPETQRFECLDRGCPPSHYGRPTHLSELKIAHVNLSPDNLHAATLDIRECAPCHPLCEVC--------EGPSTHETVCLKCRGWIYKGECVETCPSDDTYMPNE--NATLNEQELAALKAKQCLLCHRQCAGGCYAAGPEDCVNCRFRKILIDEESNKFVCNSTCPPDQPFTMPNT--NLCLDKIKYELISGAAATRTRNRILLGCSLGLFGVFLLALLIIVPCFHYKAKRRKIREALKSVYTNKAAPDMKSQAASREPNMGRLEIINSDDLQFDESSTPLGTGAFGAVYRGKWRVPKRIL---AEYNWPRSTNLDVAVKVIRSPAEPVRGTVSGKAATMEPSDTSPEAKVMERIAEKNNLNEMLSEAKVMASVSHLNCLPLIGVCLTKNMQCMVSAFVELGSIDRYLRENKDSLNSYTLLSWAEQIADGMAYLEARGIIHRDLAARNVLLQSPEHVQITDFGLAKMLDSLDENSVVVRSGRVPIRWLAIETLQFGIYSHKTDVWSYGVTLWEIFTFGKQPYENIETVDIKDHVMKGGRLTQPDICTLDAYMVMVKCWMEDYDSRPTFLELMRLFHDFCQTPGRYL 1285          
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: A0A0X3Q4X9 (Receptor protein-tyrosine kinase OS=Schistocephalus solidus OX=70667 GN=TR102389 PE=4 SV=1)

HSP 1 Score: 597.816 bits (1540), Expect = 0.000e+0
Identity = 413/1324 (31.19%), Postives = 631/1324 (47.66%), Query Frame = 2
Query:   77 WIYLHILL-ISLIFYRYSDSLIEYPEIKYCFSS----MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSV----------TGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKI-LCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP---IISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-------------------------------------------DSTSKV-----CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDC-HSRSITRLPV----CTGPSNTPGPGGCNKCQSMILRRDYQVER--CYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILE-----PCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLG----------KCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICV----FVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKF-----CLARKGKRK--RDKLKAYFSNANESDSQTPSP---PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ---------------------------------NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINP-NKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            +++L +LL      +R+S +  EYP IK C S        LD +    Y   +    + CTH+ GN+ + N++   NGS+PDL FL+ I E++G + I N+++  +PL +LR+IRG    Y    + +L NS  V      + +  ++ V+DLR L  I + N+ +  + Q C     V+++ L  +P +Q               C    T C   C+Q   + +CWGP   QCQ+ SKC     +  C +        C+  C+GGCT   SS+C AC+  L+N  C   CPPK I++  T   E N  F+    +IC+  CP   L+ +  C  +C F+        C PC    C + CT E+IF  N     +  +     +K+  C  + G + ++  +F K      P++  DDL  L NLR I G +Y+D   +P +L +L+FL NL  + +       +  +L+I N +++ +LG KSL+ +   A      + LCY  +   K I+   T           +  P  C+  G+VC  +C    GCWGPGP  C  C   + G +C  +CL +PG+ T P                                           ++ S+V     C +CH ECA+TC    +  CIG CKH  E + CV  CSR ++ ++ TK C  CH  C ++   T LPV    C+GP +  G GGC  C    +R++ + +R  C        ++      +        +         L+     PCH LC  C            T    C +C+G+ +  +CV  CP   T++  +  N++L           +C  CH QC  GCY      C++C   K+  +E    F C  +CP +   T  N+  N+C+    +  +SG         ++    L    + +        C   K KR+  R+ LK+ ++N    D ++ +    PNM  L +I+SD+L+F      LG G FG+VY GKW+         +  N  + + +DV +KV+    +                                  NE + E ++MASV H +CL LIGV    + + ++S+++ LGS+++YL +NK SL    LL WAEQIA+GM YLE   IIHRDLA RNVL+    HVQITDFGL+K+++  +++ + +  G VP+RWLAIETL+ GIYSHKTDVW+Y VTLWEIFTF   PYE ++  +I+D ++KG RL QPDIC+LD Y++M+KCW  D + RP F  L   F ++      YL
Sbjct:    7 YLFLALLLSTGGKSFRFSLT-PEYPNIKICRSRNVDCKTSLDPNIQLRYYRRQY---SECTHILGNLVLCNLRRYDNGSDPDLSFLTSIVEVSGYVYISNNDVRRIPLTSLRIIRGMVPYY----IPSLGNSALVISRNAFNKTVGLE-VLDLRKLTVIQNHNVALWDNPQLCYIAFRVDFHALFPNPKQQEALRVSNSDLISQSGCDFDNTSCHPSCVQTDTNAYCWGPEKDQCQLRSKCLHDT-SRYCLMDGYNLGTTCDDACIGGCTG-HSSNCWACRDKLNNRTCTGSCPPKYILSHVTSRQELNPEFKYDLHDICVKTCPAPFLKMDTVCVIECDFKTTIPINGSCEPCATSPCAEHCTKEQIFGTN-----FPLITSAAAEKMKTCEYYSGPIYLNRMAFEKRGSGPAPLARLDDLWNLRNLREIVGYIYLDFTGSPPELTNLTFLQNLYKVTAEFSDGVSLGIALSIYNASNLEFLGFKSLRYVDTDAYLEFLPS-LCY--LSGLKQILPMRT---------KAVKSPTTCDNEGHVCHSECLPITGCWGPGPAMCAHCCGFQAGDVCVSSCLDEPGFYTPPGLETQLVSVGASGSPFSSLQNAANIQCPTLPLTAAQLATMTAEEAISRVIPSPACARCHVECAQTCFNASNIACIGPCKHYKEANACVSNCSRNYYADETTKDCLLCHPTCSNALQSTPLPVSVAACSGPGSYLGNGGCTFCH--FIRKNPETQRFECLDRGCPPSHYGRPTHLSELKIAHVNLSPDNLHAATLDIRECAPCHPLCEVC--------EGPSTHETVCLKCRGWIYKGECVETCPSDDTYMPNE--NATLNEQELAALKAKQCLLCHRQCAGGCYAAGPEDCVNCRFRKILIDEESNKFVCNSTCPPDQPFTMPNT--NLCLDKIKYELISGAAATRTRNRILLGCSLGLFGVFLLALLIIVPCFHYKAKRRKIREALKSVYTNKAAPDMKSQAASREPNMGRLEIINSDDLQFDESSTPLGTGAFGAVYRGKWRGPKRIL---AEYNWPRSTNLDVAVKVIRSPAEPVRGTVSGKAATMEPSDTSPEAKVMERIAEKNNLNEMLSEAKVMASVSHLNCLPLIGVCLTKNMQCMVSAFVELGSIDRYLRENKDSLNSYTLLSWAEQIADGMAYLEARGIIHRDLAARNVLLQSPEHVQITDFGLAKMLDSLDENSVVVRSGRVPIRWLAIETLQFGIYSHKTDVWSYGVTLWEIFTFGKQPYENIETVDIKDHVMKGGRLTQPDICTLDAYMVMVKCWMEDYDSRPTFLELMRLFHDFCQTPGRYL 1285          
BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Match: A0A0X3P0D0 (Receptor protein-tyrosine kinase OS=Schistocephalus solidus OX=70667 GN=TR102389 PE=4 SV=1)

HSP 1 Score: 593.193 bits (1528), Expect = 0.000e+0
Identity = 413/1334 (30.96%), Postives = 633/1334 (47.45%), Query Frame = 2
Query:   77 WIYLHILL-ISLIFYRYSDSLIEYPEIKYCFSS----MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQ--------------------SVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKI-LCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP---IISTSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNP-------------------------------------------DSTSKV-----CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDC-HSRSITRLPV----CTGPSNTPGPGGCNKCQSMILRRDYQVER--CYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILE-----PCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLG----------KCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICV----FVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKF-----CLARKGKRK--RDKLKAYFSNANESDSQTPSP---PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ---------------------------------NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINP-NKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            +++L +LL      +R+S +  EYP IK C S        LD +    Y   +    + CTH+ GN+ + N++   NGS+PDL FL+ I E++G + I N+++  +PL +LR+IRG    Y    + +L NS  V      + +  ++ V+DLR L  I + N+ +  + Q C     V+++ L  +P +Q                    S +       T C   C+Q   + +CWGP   QCQ+ SKC     +  C +        C+  C+GGCT   SS+C AC+  L+N  C   CPPK I++  T   E N  F+    +IC+  CP   L+ +  C  +C F+        C PC    C + CT E+IF  N     +  +     +K+  C  + G + ++  +F K      P++  DDL  L NLR I G +Y+D   +P +L +L+FL NL  + +       +  +L+I N +++ +LG KSL+ +   A      + LCY  +   K I+   T           +  P  C+  G+VC  +C    GCWGPGP  C  C   + G +C  +CL +PG+ T P                                           ++ S+V     C +CH ECA+TC    +  CIG CKH  E + CV  CSR ++ ++ TK C  CH  C ++   T LPV    C+GP +  G GGC  C    +R++ + +R  C        ++      +        +         L+     PCH LC  C            T    C +C+G+ +  +CV  CP   T++  +  N++L           +C  CH QC  GCY      C++C   K+  +E    F C  +CP +   T  N+  N+C+    +  +SG         ++    L    + +        C   K KR+  R+ LK+ ++N    D ++ +    PNM  L +I+SD+L+F      LG G FG+VY GKW++        +  N  + + +DV +KV+    +                                  NE + E ++MASV H +CL LIGV    + + ++S+++ LGS+++YL +NK SL    LL WAEQIA+GM YLE   IIHRDLA RNVL+    HVQITDFGL+K+++  +++ + +  G VP+RWLAIETL+ GIYSHKTDVW+Y VTLWEIFTF   PYE ++  +I+D ++KG RL QPDIC+LD Y++M+KCW  D + RP F  L   F ++      YL
Sbjct:    7 YLFLALLLSTGGKSFRFSLT-PEYPNIKICRSRNVDCKTSLDPNIQLRYYRRQY---SECTHILGNLVLCNLRRYDNGSDPDLSFLTSIVEVSGYVYISNNDVRRIPLTSLRIIRGMVPYY----IPSLGNSALVISRNAFNKTVGLE-VLDLRKLTVIQNHNVALWDNPQLCYIAFRVDFHALFPNPKQQEALRVSNSDLISQSGCDFGSSQSHTNLANNTSCHPSCVQTDTNAYCWGPEKDQCQLRSKCLHDT-SRYCLMDGYNLGTTCDDACIGGCTG-HSSNCWACRDKLNNRTCTGSCPPKYILSHVTSRQELNPEFKYDLHDICVKTCPAPFLKMDTVCVIECDFKTTIPINGSCEPCATSPCAEHCTKEQIFGTN-----FPLITSAAAEKMKTCEYYSGPIYLNRMAFEKRGSGPAPLARLDDLWNLRNLREIVGYIYLDFTGSPPELTNLTFLQNLYKVTAEFSDGVSLGIALSIYNASNLEFLGFKSLRYVDTDAYLEFLPS-LCY--LSGLKQILPMRT---------KAVKSPTTCDNEGHVCHSECLPITGCWGPGPAMCAHCCGFQAGDVCVSSCLDEPGFYTPPGLETQLVSVGASGSPFSSLQNAANIQCPTLPLTAAQLATMTAEEAISRVIPSPACARCHVECAQTCFNASNIACIGPCKHYKEANACVSNCSRNYYADETTKDCLLCHPTCSNALQSTPLPVSVAACSGPGSYLGNGGCTFCH--FIRKNPETQRFECLDRGCPPSHYGRPTHLSELKIAHVNLSPDNLHAATLDIRECAPCHPLCEVC--------EGPSTHETVCLKCRGWIYKGECVETCPSDDTYMPNE--NATLNEQELAALKAKQCLLCHRQCAGGCYAAGPEDCVNCRFRKILIDEESNKFVCNSTCPPDQPFTMPNT--NLCLDKIKYELISGAAATRTRNRILLGCSLGLFGVFLLALLIIVPCFHYKAKRRKIREALKSVYTNKAAPDMKSQAASREPNMGRLEIINSDDLQFDESSTPLGTGAFGAVYRGKWRVPKRIL---AEYNWPRSTNLDVAVKVIRSPAEPVRGTVSGKAATMEPSDTSPEAKVMERIAEKNNLNEMLSEAKVMASVSHLNCLPLIGVCLTKNMQCMVSAFVELGSIDRYLRENKDSLNSYTLLSWAEQIADGMAYLEARGIIHRDLAARNVLLQSPEHVQITDFGLAKMLDSLDENSVVVRSGRVPIRWLAIETLQFGIYSHKTDVWSYGVTLWEIFTFGKQPYENIETVDIKDHVMKGGRLTQPDICTLDAYMVMVKCWMEDYDSRPTFLELMRLFHDFCQTPGRYL 1295          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629])

HSP 1 Score: 264.233 bits (674), Expect = 5.472e-72
Identity = 164/552 (29.71%), Postives = 265/552 (48.01%), Query Frame = 2
Query: 2246 ISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKAD---ETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL--------SYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPH-----SPNQNRVRVIGNMRPRGNQKSII---VPEHVQRFLNG 3826
            ++ SK    GC +C  +     CV+ CP+     K     +   S+  C  CH  C  GC G +   C     F                  S     +      I  FV LS                      +     + R+  +++  L+         +  TPS   PN + L ++     + I   ++LG G FG+VY G W  +             +D K+ V IKVL  +       E +DE  +MASV H H  RL+G+    + +L +S  MP G +  Y+++NK ++  + LL W  QIA GM YLE+ H++HRDLA RNVL+    HV+ITDFGL+K+++ ++ E    GG VP++W+A+E++    Y+H++DVW+Y VT+WE+ TF T PY+ + A EI   + KG RL QP IC++D+Y++M+KCW +D E RP F  L  EF   + +   YL          P+   +    +  + +++ +  D   Y  P+     SP+ +R +++ ++     ++S++   +P+   RFL+G
Sbjct:  511 LTCSKPGPDGCVECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQGCTGPELKDCREYKPF------------------SGMSVIAAGVVGGILAFVILS----------------------LGVAVLVRRRHIKRKRTLRRLLQERELVEPLTPSGEAPNQSLLRILKETEFKKI---KVLGSGAFGTVYKGLWVPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTSTVQL-VSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADEKEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVIQGDERMHLPSPTDSKFYRSLMSGVDLDESMDADEYLMPNHGFFSSPSTSRTQLLHSVNLFPVRESLMLRYIPDPTDRFLDG 1006          

HSP 2 Score: 157.147 bits (396), Expect = 3.250e-38
Identity = 163/632 (25.79%), Postives = 246/632 (38.92%), Query Frame = 2
Query:  173 MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKIT---------KTCEPCHKDCHSRSITRLPVCTGP 2008
            M LL        N +K  + +NCT     + + N++      E DL FL  I+E+ G + I  +    +PL NLR                                              I+ G+        + L+N   ++ L +    S+TGK       C   C     +G CW P  + CQ F+K      C+ RC   +  D  CCN  C  GCT    + C+AC+   D+N C+  CPP  + N  T    PN   +  F   C+  CP   ++   G C   C+   YE   D   +C  C+ LC ++C+   + +         S++   +    NCTT  G V I   +         P  +   L     ++ I+GS+ +     P  + SLS   NL+ I        T SL I    I++LGL++L+ I +  +    N KLCY   + +K + +++  + V     N  ADP  C      C   C  + GCWGPGP  C SC +      C   C +  G     +  +  CL+C  EC     + TCS    D C+  C H  +   CV  C +     K T         + C+ CH++C          CTGP
Sbjct:   27 MTLLSTVDEHYQNMVK--MYSNCT-----VILENLEITYTSHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLR----------------------------------------------IIRGHTLYDGLALAVLSNYNNSKGLRELPLISLTGK------MCHSDCY----NGSCWAPGRANCQTFTKLTCAEQCSGRCKGPKPSD--CCNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGKYNFGATCVKNCPHNYVVTDHGACVRSCSPGTYEVDEDGVRKCKKCEGLCPKVCSGLGVGN----LVGVMSINSSNIDSFENCTTINGDVLILKTTLNGDTFTKTPKMDPAKLNVFRTVKEITGSLLVQY--WPKNMPSLSPFENLEVIRGRTKHQGTVSLGIGKLPITHLGLRALREISDGDVSISANAKLCYNSPEHWKRLFRSE--DQVARPMQN--ADPATCAALNQTCDEMCTPE-GCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECE-VNMTCLECDPECRPLNGSLTCSKPGPDGCV-ECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQG-------CTGP 573          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629])

HSP 1 Score: 260.381 bits (664), Expect = 1.661e-70
Identity = 167/566 (29.51%), Postives = 264/566 (46.64%), Query Frame = 2
Query: 2246 ISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKAD---ETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL--------SYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPH-----SPNQNRVRVI----------------GNMRP-RGNQKSIIVPEHVQRFLNG 3826
            ++ SK    GC +C  +     CV+ CP+     K     +   S+  C  CH  C  GC G +   C     F                  S     +      I  FV LS                      +     + R+  +++  L+         +  TPS   PN + L ++     + I   ++LG G FG+VY G W  +             +D K+ V IKVL  +       E +DE  +MASV H H  RL+G+    + +L +S  MP G +  Y+++NK ++  + LL W  QIA GM YLE+ H++HRDLA RNVL+    HV+ITDFGL+K+++ ++ E    GG VP++W+A+E++    Y+H++DVW+Y VT+WE+ TF T PY+ + A EI   + KG RL QP IC++D+Y++M+KCW +D E RP F  L  EF   + +   YL          P+   +    +  + +++ +  D   Y  P+     SP+ +R +++                GN+ P R +     +P+   RFL+G
Sbjct:  571 LTCSKPGPDGCVECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQGCTGPELKDCREYKPF------------------SGMSVIAAGVVGGILAFVILS----------------------LGVAVLVRRRHIKRKRTLRRLLQERELVEPLTPSGEAPNQSLLRILKETEFKKI---KVLGSGAFGTVYKGLWVPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTSTVQL-VSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADEKEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVIQGDERMHLPSPTDSKFYRSLMSGVDLDESMDADEYLMPNHGFFSSPSTSRTQLLHSVSLNSSIGSCQNRNGNLFPVRESLMLRYIPDPTDRFLDG 1080          

HSP 2 Score: 182.185 bits (461), Expect = 6.446e-46
Identity = 167/633 (26.38%), Postives = 266/633 (42.02%), Query Frame = 2
Query:  173 MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNI-YISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKIT---------KTCEPCHKDCHSRSITRLPVCTGP 2008
            M LL        N +K  + +NCT     + + N++      E DL FL  I+E+ G + I  +    +PL NLR+IRG +          L +   +++  + + S  ++  + L SL  I+ G + +  + +  ++  ++W +++          K     +K  K C     +G CW P  + CQ F+K      C+ RC   +  D  CCN  C  GCT    + C+AC+   D+N C+  CPP  + N  T    PN   +  F   C+  CP   ++   G C   C+   YE   D   +C  C+ LC ++C+   + +         S++   +    NCTT  G V I   +         P  +   L     ++ I+GS+ +     P  + SLS   NL+ I        T SL I    I++LGL++L+ I +  +    N KLCY   + +K + +++  + V     N  ADP  C      C   C  + GCWGPGP  C SC +      C   C +  G     +  +  CL+C  EC     + TCS    D C+  C H  +   CV  C +     K T         + C+ CH++C          CTGP
Sbjct:   42 MTLLSTVDEHYQNMVK--MYSNCT-----VILENLEITYTSHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLRIIRGHT----------LYDGLALAVLSNYNNSKGLRE-LPLISLTEILKGGVKFAHNPYLCNVETIQWADIMSSKDSSQFV-KFESTTSKDCKMCHSDCYNGSCWAPGRANCQTFTKLTCAEQCSGRCKGPKPSD--CCNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGKYNFGATCVKNCPHNYVVTDHGACVRSCSPGTYEVDEDGVRKCKKCEGLCPKVCSGLGVGN----LVGVMSINSSNIDSFENCTTINGDVLILKTTLNGDTFTKTPKMDPAKLNVFRTVKEITGSLLVQY--WPKNMPSLSPFENLEVIRGRTKHQGTVSLGIGKLPITHLGLRALREISDGDVSISANAKLCYNSPEHWKRLFRSE--DQVARPMQN--ADPATCAALNQTCDEMCTPE-GCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECE-VNMTCLECDPECRPLNGSLTCSKPGPDGCV-ECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQG-------CTGP 633          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: ENSAMXT00000016431.2 (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103032492])

HSP 1 Score: 251.136 bits (640), Expect = 3.166e-68
Identity = 125/319 (39.18%), Postives = 186/319 (58.31%), Query Frame = 2
Query: 2732 TPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYI 3679
            TPS    N  L+      EF    ++LG G FG+VY G W  +             +D K+ V IKVL          E +DE  +MASV H H  RL+G+    + +L I+  MP G +  Y+ +N+ ++  + LL W  QIA GM YLE + ++HRDLA RNVL+   NHV+ITDFGL+K++N N+ E    GG VP++W+A+E++    Y+H++DVW+Y VT+WE+ TF   PY+ + A EI   + KG RL QP IC++D+Y++M+KCW +DP+ RP F  L +EF   + +   YL     EQ + + + +  +
Sbjct:  637 TPSGAAPNQALLRILKETEF-KKVKVLGSGAFGTVYKGLWIPEG------------EDVKIPVAIKVLREVTSPKANKEILDEAYVMASVDHPHICRLLGICLTSTVQL-ITQLMPFGCLLDYIRENQDNIGSQNLLNWCVQIAKGMNYLEEHRLVHRDLAARNVLVKTPNHVKITDFGLAKLLNANEKEYHSDGGKVPIKWMALESILHWTYTHQSDVWSYGVTVWELMTFGAKPYDGIPAQEISGLLEKGERLPQPSICTIDVYMIMVKCWMIDPDSRPRFRELSSEFTKMARDPTRYLVIQGDEQLHLSGSTDRRV 941          

HSP 2 Score: 166.392 bits (420), Expect = 3.690e-41
Identity = 167/617 (27.07%), Postives = 274/617 (44.41%), Query Frame = 2
Query:  191 SQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKII--NRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIS-TSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADP-KLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPG----YLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRT----------HFLNKITKTCEPCHKDC 1966
            SQ+ ++      + +NCT V  N+ I +V     G   DL FL  I+E+ G + I  ++++ +PL NLR+IRG S LY        +  F +++  +   +NS        +  SI +G                   L E P R ++ GK       C K C     +G CW P    CQ  ++  C ++ C++RC      D  CCN  C  GCT   ++ C+AC+   D+ +C+  CP   +   N    +  PN  F   F   C+  CP   ++   G C   C  + +E + +   +C  C   C ++C        N       +++   +    NCT   G + I   +         P  +   L + + ++ I+G  ++ ++  P  L SLS   NL+ I          S   +N   I YLGL+SLK I +  +  KNN +LCY +   ++ + ++DT    TI + + + D     E +  +C   C  + GCWGPGP+ C SC +V     C ++C +  G    Y++N      +CL+C  EC +T +G  +DQC+  C H  + S CV +C+             F++K  + C+PCH +C
Sbjct:   38 SQADDHYRALMKMYSNCTVVLENLEITHV-----GENYDLSFLRSIEEVGGYVLIAINDVNVIPLENLRLIRGHS-LY--------EGKFALAVMANYHTANSSS------AESSIPTG-------------------LRELPLR-NLRGK------PCDKSCY----NGSCWAPGPENCQKLTRLICAEQ-CSHRCKGPAIAD--CCNEHCAAGCTGPLATDCLACREFKDDGMCKDACPRLMLYDPNLHQLVVNPNGKFS--FGATCVKNCPHNYVVTDHGACVRTCGDKTHEVEENGIRKCKNCNGPCPKVCN----GLGNGELAGIMTVNASNIDTFQNCTKINGDISIFATTLRGDPYTKTPKLDPAKLDYFKTVKEITG--FLLIQAWPENLTSLSPFENLEVIRGRTQQHGRVSFAALNIAHIEYLGLRSLKEISDGDVVIKNNPRLCYTNANYWRKLFRSDTQ---TIKTRDNLGDSCNSAEVQNRMCDGMCTEE-GCWGPGPSMCFSCRHVSRQGQCVDSCNILEGMPREYISN-----NMCLECDQEC-RTLNGTPTDQCV-ECAHFKDGSNCVSQCANGVPGMNNRLIWTFVDK-NRQCQPCHPNC 581          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: erbb4b (erb-b2 receptor tyrosine kinase 4b [Source:ZFIN;Acc:ZDB-GENE-030918-5])

HSP 1 Score: 252.677 bits (644), Expect = 6.477e-68
Identity = 149/485 (30.72%), Postives = 242/485 (49.90%), Query Frame = 2
Query: 2201 CHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPK----VRTFL-KADETNSSLGKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C +  +QC    D  ++ +      C +C  +     CV  CP       +F+ K  E N+   +CHPCH  C  GC G     CI                  ++  P       G     + V V ++                      +     + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ +   +ILG G FG+VY G W  +             +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NH++ITDFGL+++++ ++ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   EI D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  501 CLECDAQCQKADDDGLTCTGPGPDHCVKCLHFKDGPNCVEKCPDGLQGTNSFIFKYAEANN---ECHPCHANCTQGCTGPRLQDCI----------------GMIDRTPLIAAGVIGG----LFVVVIIA----------------------LGVAVSVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV---KILGAGAFGTVYKGIWVPEG------------ETVKIPVAIKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFCRMARDPQRYL 924          

HSP 2 Score: 183.726 bits (465), Expect = 2.386e-46
Identity = 167/625 (26.72%), Postives = 265/625 (42.40%), Query Frame = 2
Query:  206 YNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQ--KGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQ---CVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSITRLPVCTGP 2008
            Y TL++    NC  V GN+ I ++         DL FL  I+E+TG + +  +    +PL NLR+IRG +RLY  +   AL        D +  +       + L++L  I+ G +Y+  ++F      + W +++++     +       P+  S  C +  +  +G CWGP  +QCQ  +K      C  RCF     D  CC+ +C GGC+    + C AC    D+  C  +CP   + N  T   E N   +  +   C+ KCP   +     C   C   K E + ++   C+PC  +C + C      S    +    ++D   + K  NCT   G   F+    +  V H  E +   + + L     +R I+G     L    F    +S L   Q                   I+ L L+S++ I    ++  NN++LCY++   + ++ +  T     +I +N   DPK C     +C   C S  GCWGPGP+ C+SC     G  C E+C +  G +    +   VCL+C  +C K      TC+G   D C+  C H  +   CV +C         F+ K  +    C PCH +C          CTGP
Sbjct:   15 YRTLRK-YYENCEVVMGNLEITSIDRSR-----DLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRG-TRLY--EDRYALAIFLNYRRDGNFGLRQ-----LGLKNLTEILHGGVYVDQNKFLCHADTIHWQDIVKNARSDHLV-----VPSNSSSSCQRCHRACNGRCWGPKENQCQSLTKTVCAEQCDGRCFGPYVSD--CCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPRAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENKIKMCIPCTDICPKACDGIGTASLQTAQ----TVDSSNIDKFINCTKINGNLVFLITGIKGDVYHNIEAL---DPEKLNVFRTVREITGKTRSILT---FSGRGISLLVLKQQW-----------------ITSLQLQSMREISAGNVYITNNSQLCYYNTINWTSLFRIPTQK--ALIRNN--RDPKECIMEKMICDPLC-SDGGCWGPGPDQCLSCRFFSRGRTCVESCNLHQGDVRE-FANGSVCLECDAQCQKADDDGLTCTGPGPDHCV-KCLHFKDGPNCVEKCPDGLQGTNSFIFKYAEANNECHPCHANCTQG-------CTGP 577          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Match: ENSAMXT00000051131.1 (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103032492])

HSP 1 Score: 251.906 bits (642), Expect = 6.700e-68
Identity = 125/319 (39.18%), Postives = 186/319 (58.31%), Query Frame = 2
Query: 2732 TPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYI 3679
            TPS    N  L+      EF    ++LG G FG+VY G W            +   +D K+ V IKVL          E +DE  +MASV H H  RL+G+    + +L I+  MP G +  Y+ +N+ ++  + LL W  QIA GM YLE + ++HRDLA RNVL+   NHV+ITDFGL+K++N N+ E    GG VP++W+A+E++    Y+H++DVW+Y VT+WE+ TF   PY+ + A EI   + KG RL QP IC++D+Y++M+KCW +DP+ RP F  L +EF   + +   YL     EQ + + + +  +
Sbjct:  698 TPSGAAPNQALLRILKETEF-KKVKVLGSGAFGTVYKGLW------------IPEGEDVKIPVAIKVLREVTSPKANKEILDEAYVMASVDHPHICRLLGICLTSTVQL-ITQLMPFGCLLDYIRENQDNIGSQNLLNWCVQIAKGMNYLEEHRLVHRDLAARNVLVKTPNHVKITDFGLAKLLNANEKEYHSDGGKVPIKWMALESILHWTYTHQSDVWSYGVTVWELMTFGAKPYDGIPAQEISGLLEKGERLPQPSICTIDVYMIMVKCWMIDPDSRPRFRELSSEFTKMARDPTRYLVIQGDEQLHLSGSTDRRV 1002          

HSP 2 Score: 197.978 bits (502), Expect = 6.463e-51
Identity = 180/657 (27.40%), Postives = 305/657 (46.42%), Query Frame = 2
Query:  146 PEIKYCFSSMDLLDG-SQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEV-SIDQDISVSNSIKTVIDLRSLRSIVSGNIYIS--SQFCSSLANVEWNELL-EDPTRQSVTGKCTPQPTK-CSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKII--NRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIS-TSLTIIN-TDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPG----YLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRT----------HFLNKITKTCEPCHKDCHSRSITRLPVCTGPS 2011
            PE K C  + + L+  SQ+ ++      + +NCT V  N+ I +V     G   DL FL  I+E+ G + I  ++++ +PL NLR+IRG S      ++  + N     S   + S+   ++  + LR+LR I+ G + I+   + C+ +  ++W++++ ++ T   +T + T    K C K C     +G CW P    CQ  ++  C ++ C++RC      D  CCN  C  GCT   ++ C+AC+   D+ +C+  CP   +   N    +  PN  F   F   C+  CP   ++   G C   C  + +E + +   +C  C   C ++C        N       +++   +    NCT   G + I   +         P  +   L + + ++ I+G  ++ ++  P  L SLS   NL+ I          S   +N   I YLGL+SLK I +  +  KNN +LCY +   ++ + ++DT    TI + + +A P+ CE +  +C   C  + GCWGPGP+ C SC +V     C ++C +  G    Y++N      +CL+C  EC       +C G  +DQC+  C H  + S CV +C+             F++K  + C+PCH +C          CTGP 
Sbjct:   22 PERKVCQGTSNKLNLLSQADDHYRALMKMYSNCTVVLENLEITHV-----GENYDLSFLRSIEEVGGYVLIAINDVNVIPLENLRLIRGHSLYEGKFALAVMANYHTANSSSAESSIPTGLRE-LPLRNLREILRGGVRIARNPRLCN-IETIKWHDIVSKESTNAVITSESTDSTCKPCDKSCY----NGSCWAPGPENCQKLTRLICAEQ-CSHRCKGPAIAD--CCNEHCAAGCTGPLATDCLACREFKDDGMCKDACPRLMLYDPNLHQLVVNPNGKFS--FGATCVKNCPHNYVVTDHGACVRTCGDKTHEVEENGIRKCKNCNGPCPKVCN----GLGNGELAGIMTVNASNIDTFQNCTKINGDISIFATTLRGDPYTKTPKLDPAKLDYFKTVKEITG--FLLIQAWPENLTSLSPFENLEVIRGRTQQHGRVSFAALNIAHIEYLGLRSLKEISDGDVVIKNNPRLCYTNANYWRKLFRSDTQ---TIKTRDNLA-PEACEVQNRMCDGMCTEE-GCWGPGPSMCFSCRHVSRQGQCVDSCNILEGMPREYISN-----NMCLECDQECRTLNGTPSCHGPGADQCV-ECAHFKDGSNCVSQCANGVPGMNNRLIWTFVDK-NRQCQPCHPNCTHG-------CTGPG 637          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003172.1 (pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 gene:ENSPMAG00000002842.1 transcript:ENSPMAT00000003172.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 258.84 bits (660), Expect = 5.084e-72
Identity = 150/459 (32.68%), Postives = 230/459 (50.11%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSL----GKCHPCHPQC-NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNA-NESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C +C  Y     CVS CP V    + DE  S        C PCHP C +GC G     C               L   +    S             CV + L  +                         C+ R+   ++  ++ Y      E  + + + PN   L ++    L     G++LG G FG+V+ G W  +             +D K+ V IKVL  +       E +DE  IMASV H H +RL+G+    S +L ++  MPLG + +Y  ++K+ +  ++LL WA QIA GM+YLE   ++HRDLA RNVL+    HV+ITDFGL+++++ N+ E    GG +P++WLA+E+++   ++H++DVW+Y VT+WE+ TF   PYE + A +I + + KG RL QP IC++D+Y++M+KCW +D E RP F+ L  EF   + + + YL
Sbjct:  438 CVRCAHYKDGPHCVSACP-VGAQGENDEIISKYPDKNNTCQPCHPNCSHGCKGGGLLDC--------------HLIGPLFRTGSPVLAVMAVGGLFACVMLLLLAV------------------------VCVRRRNIARKRAMRRYIEKELVEPLTPSGAAPNQAQLRILKETELR---KGKMLGSGAFGTVHKGIWTPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYIMASVSHPHLVRLLGICLTPSVQL-VTQLMPLGCLLEYTREHKEHIGSQLLLNWAVQIAKGMMYLEEQRLVHRDLAARNVLVRTPQHVKITDFGLARLLDINEIEYHADGGKMPIKWLALESIQYRTFTHQSDVWSYGVTIWELMTFGGKPYEGIPARDIPELLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFKELAVEFSKMARDPQRYL 841          

HSP 2 Score: 146.747 bits (369), Expect = 6.834e-36
Identity = 135/505 (26.73%), Postives = 215/505 (42.57%), Query Frame = 2
Query:  527 LRSIVSGNIYISSQFCSSLAN-VEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGD--EECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQ---GDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIES-LVPIISTSLTIINT---DISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNG-MADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVREC------SRTHFLNKI---TKTCEPCHKDC 1966
            L  I+ G +YI         N V+W +++++ +  ++    +   T C K C +      CWG     CQ   KC K  CA +C     G    ECC+SQC  GC     + C AC+   D+  C   CPP  I N  T     N   +  +  IC+ +CP   +     C   C   K+E +     +C  C  +C + C  + I + N  +    ++D   +    NCT   G +   T          +P  + D L    +++ I+G + I  +  P  +   +   NL  I   ++  +  + +++     +I+ LGL SL+ +    ++ KNN +LCY++  K+  +  ++     + + DN   AD   C   G VC + C S+ GCWGPGP+ CISC   R    C E+C +  G          VC  C  EC     + TC G  S+ C+  C H  +   CV  C           ++K      TC+PCH +C
Sbjct:    1 LSEILHGGVYIKENKHLCYHNTVDWWDIVKEGSIVNIDMDNSTTCTSCHKGCHKH-----CWGNGMKYCQ---KCTKLTCARQCDGRCHGPTPSECCHSQCAAGCDGPRDTHCFACKNFNDSGSCVSHCPPPTIYNPVTFAQGENPDVKYSYGAICVKECPHNFVVDYNSCVRACPAGKHEVEKFGKKKCETCTDVCPKAC--DGIGTGNLSRSQ--TVDATNIDTFENCTKINGNIAFLTTGIKGDDYMKIPPLDPDKLNVFRSIKEITGHLMI--QAWPENMTDFAVFENLTTIRGRVLQSVGRTFSLLVARIPNITALGLASLQEVSAGNVYLKNNERLCYYNTIKWPAVFVSE--QQTSYVHDNKPEAD---CNADGAVCDLLC-SEHGCWGPGPDQCISCRFFRRARSCVESCYITEGPYRE-HMQDAVCAPCDPECLPVNDSVTCFGPGSNSCV-RCAHYKDGPHCVSACPVGAQGENDEIISKYPDKNNTCQPCHPNC 483          

HSP 3 Score: 56.9954 bits (136), Expect = 3.434e-8
Identity = 67/273 (24.54%), Postives = 107/273 (39.19%), Query Frame = 2
Query:  191 SQSSNYNTLKQDLGNNCTHVYGNI--FINNVKSESNGSEPDLE-----FLSGIKEITGSLKIRN--SNISSVPL-RNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI--SSQFCSSLANVEWNELLEDPTRQSVT------GKCTPQPTKCSKKCMQKGKSGFCWGPLTSQ---CQIFSKCRKRMCANRCFLSE------TGDEEC--CNSQCLG-----GCTSSDSSSCIACQGVLDNNVCQPECP 907
            S+S   +    D   NCT + GNI      +K +     P L+         IKEITG L I+    N++   +  NL  IRG         + ++  +F + + +  ++     T + L SL+ + +GN+Y+  + + C     ++W  +     + S          C      C   C + G    CWGP   Q   C+ F   R R C   C+++E        D  C  C+ +CL       C    S+SC+ C    D   C   CP
Sbjct:  202 SRSQTVDATNIDTFENCTKINGNIAFLTTGIKGDDYMKIPPLDPDKLNVFRSIKEITGHLMIQAWPENMTDFAVFENLTTIRGRV-------LQSVGRTFSLLVARIPNI-----TALGLASLQEVSAGNVYLKNNERLC-YYNTIKWPAVFVSEQQTSYVHDNKPEADCNADGAVCDLLCSEHG----CWGPGPDQCISCRFFR--RARSCVESCYITEGPYREHMQDAVCAPCDPECLPVNDSVTCFGPGSNSCVRCAHYKDGPHCVSACP 455          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005822.1 (pep scaffold:Pmarinus_7.0:GL476959:64997:68848:-1 gene:ENSPMAG00000005273.1 transcript:ENSPMAT00000005822.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 178.718 bits (452), Expect = 2.531e-51
Identity = 79/185 (42.70%), Postives = 124/185 (67.03%), Query Frame = 2
Query: 3158 GMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQ-NYTTNTFNNYIEIKQHEDEIS 3709
            GM YLE+  ++HRDLA RNVL+   NHV+ITDFGL+K+++ N+ E    GG +P++WLA+E+++  I++H++DVW+Y VTLWE+ TF   PY+ + A +I + + KG RL QP IC++D+Y++M+KCW +D E RP F  L  EF   + +   YL     E+    + T + +++    ED++S
Sbjct:    1 GMNYLEDRRLVHRDLAARNVLVKAPNHVKITDFGLAKLLDLNETEYHSEGGKLPIKWLALESIQQRIFTHQSDVWSYGVTLWELMTFGGKPYDGVPARDIPELLEKGERLTQPPICTIDVYMIMVKCWMIDAESRPKFRELAAEFSKMARDPTRYLVIQGDERMKLPSPTDSRFLQSLMEEDDMS 185          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236])

HSP 1 Score: 178.333 bits (451), Expect = 9.915e-46
Identity = 96/324 (29.63%), Postives = 168/324 (51.85%), Query Frame = 2
Query: 2675 RKRDKLKAYFSNANESDSQTPSP----PNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            RKR  L+ Y  N      Q  +P    PN   L ++    L+    G++LG G FG+VY G W  +             +  K+ V +KVL  S       + +DE  +MASV H H +RL+G+    + +L ++  MP G + +Y+ +++  +  +++L W  QIA     ++   ++  DL    + +     + +    L + I+   D        +P++W+A+E+++   ++H++DVW+Y VT+WE+ TF   PY+ + A +I   + KG RL QP +C++D+Y++M+KCW +D E RP F  L T+F   + +   YL
Sbjct:  647 RKR-TLRKYVENERPQLVQPLTPSGAQPNQAQLRILKETELK---KGKVLGSGAFGTVYKGIWVPEG------------ESVKIAVAVKVLRDSASSKANKDILDEAYLMASVDHPHLVRLLGICMSSTTQL-VTQLMPHGCLLEYVREHRGRVGSQLILNWCVQIAKNASEIQALQMVCDDLVRLVMSLRTPPRITLASANLFQSID---DAKHWHDRDMPIKWMALESIQYRKFTHQSDVWSYGVTVWELMTFGGKPYDGISARDIPGLLEKGERLPQPPVCTIDVYMIMVKCWMIDAESRPRFSELATDFSKMARDPSRYL 950          

HSP 2 Score: 116.701 bits (291), Expect = 1.431e-26
Identity = 156/648 (24.07%), Postives = 260/648 (40.12%), Query Frame = 2
Query:  173 MDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLR--SLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSV---TGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIAC------QGVLDNNVC---------QPECPPK-KIINRETGIPE-PNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKI-LCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQ--IDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQ-AIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSR------THFLNKITK---TCEPCHKDCHSRSI 1981
            M LL GS    YNTL+  +  NC  V GN+ I  ++   NGS  DL FL  I+E++G + I  + +  VPL NLRV+RG +RLY        + +  V ++ + SV      + +LR   L  I+ G +Y+  +         W+++    ++++       C       S +        FCWG     CQ F+   C K+ C  RC+  +    +CC+  C  GCT    + C           + DN +C         Q + PP+  +  R+  + + P   F   + N C+  CP    E E     +            C PC   LC ++C   +       K +  ++D   +   +NCTT  G   F++   D     ++   + P       +  ++L+ ++GS+   L   P +   L FL +L  +  S        + +++  + ++ ++    +K+  +    +   C+       ++  T +        D          + G VC   C ++ GCWGPGP  C+SC   + G  C E+C V  G       +  +C+ CH EC     + TC G   D C   C++  E   CV  C           + K       C PCH +C    I
Sbjct:    8 MSLL-GSAEKQYNTLR-SMYTNCEVVMGNLEITYIR---NGS--DLSFLRTIREVSGYVLIALNEVDHVPLENLRVVRG-TRLYDQ------RYALTVLLNYNDSVPEERLGLKELRLTRLTEILRGGVYVRKE----PGLPSWDDIRNRNSKENFFLPVVACDFSSVSLSGQPCHPSCKNFCWGSGPQYCQTFTSTICAKQ-CDGRCYGLDP--NQCCHKHCASGCTGPRETDCFPASSWRSRASIQDNVLCGLFFSVTIYQFDNPPRGNLALRQALVADFPAGNFVVDY-NSCVRSCPVNKTEVEDGSGVK-----------HCKPCPDNLCPKVC---DGIGSGKLKEAQ-TVDAKNIHFFSNCTTISGNLIFLRNGFDGNCHFQNGIHVKP-------RCCQSLQQLTGSLL--LNHYPVRWQVLPFLLHLDLSKPSRKQFWRLHVLLVHKSLLFMLMRYCTYVKSFQVTATVHPIFCFVSTLFGSSLYSTKSNGRHCCACDRP-------GKEGYVCDALCSAE-GCWGPGPMQCLSCKFHKRGKTCVESCSVLDGD-EREFVSGALCIACHAECMLINGSLTCHGPGPDNCT-RCRNYREGPHCVGFCPEGVPGESGELIYKYPDEDGVCHPCHYNCTQGEI 599          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010487.1 (pep scaffold:Pmarinus_7.0:GL501102:818:30108:-1 gene:ENSPMAG00000009497.1 transcript:ENSPMAT00000010487.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 167.548 bits (423), Expect = 3.088e-43
Identity = 166/625 (26.56%), Postives = 269/625 (43.04%), Query Frame = 2
Query:  191 SQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSI--DQDISVSNSIKTVIDLRSLRSIVSGNIYISSQ-FCSSLANVEWNELLEDPT-RQSVTGKCTPQ-PTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLS--ETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQ------ICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL-VPIISTSLTIINT-DISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLN-DVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKT-----CSGLRSDQCIGGCKHAMENSMCVREC---SRTHFLNKITK------TCEPCHKDC 1966
            S++ +Y +LK  L   C  V GN+ I ++   S G   DL FL  ++E+ G + +  ++   +PL +LR++RG         M    + F ++I  +    +   ++ ++ LRSL  I+SG + I+   F      ++W ++LE     QSV     P   +  S+    +G S  CW   T+ CQ   K  + +CA  C L    T   +CC+  C  GCT    + C+AC+   D  VC   CPP  I NR+T + EPN   +     IC+ +CP+  L  E  C   C   K E + +    CK   E+      +C      +  D K    S+    +   + CTT  G   F++   +S +   PE         +K   ++R I+G  Y+ ++     +  LS   NL+ +    +  +  S+ + N   +  LGL++L  +   ++  +N  +LCY     +  ++++     D+  +  + +     C      C   C S  GCWGPGP  C+ C   + G  C E+C    G +        +C  CH EC  T     C G  SD C   C+H  +   CV +C     T     I K       C PCH +C
Sbjct:   39 SKTQHYESLKI-LYQGCEVVLGNLEITHL---SRGD--DLSFLKDVREVMGYVLVALNDFEELPLESLRIVRG---------MKLYDDKFALAIVDNGQRGLGTGLRALL-LRSLTEILSGGVNITDNPFLCHADTIKWEDILEQKNLNQSVLPYGRPDCESPASRPPCPQGCS-HCWSADTNYCQ---KLTRTICAKECTLRCYGTNTNQCCHKHCASGCTGPRDTDCLACKTFNDTGVCVMHCPPTHIYNRDTYLQEPNPDVKYSHGAICVKRCPQNFLIDENSCARSCPHEKMEVEENGVKMCKACSEKQGCPKVVCHGIGSGNLKDAK----SVSSLNVDTFSECTTINGNLVFLESGLDSDLLAHPE--------KMKVFRSVREITG--YLHIEAWLPNMTDLSVFENLEIVRGRNIRSVGYSVLVRNLPHLEVLGLRALSEVTEGSVLAQNVPRLCYVLTVNWTRLLRSPRQKADLEGVPSSSVC-VFACRAGSEACHPLCSSD-GCWGPGPEQCMQCKLFKRGRTCVESCNQNDGEVRE-FINGTLCTPCHSECLPTNGTLSCKGPTSDMCT-RCRHFKDGPYCVDKCPLGQNTEHGALIFKFPDAHNACMPCHANC 625          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Match: fer (fer (fps/fes related) tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-060526-234])

HSP 1 Score: 166.777 bits (421), Expect = 2.287e-42
Identity = 94/273 (34.43%), Postives = 143/273 (52.38%), Query Frame = 2
Query: 2792 IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQ---NEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGM---VPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEF 3592
            I+ GE LGKG FG VYAG+ K                 S V V +K  + +  Q   N F+ E RI+    H + +RLIGV  + +   ++   +  G    +L +    L+   LL ++EQ A GM YLE+++ IHRDLA RN L+ + + ++I+DFG+S+      D + +  G+   +P++W A E L  G Y+  +DVW+Y + LWEIF+  + PY         +++  G R+  P +C   IY LML+CW    E+RP F  L  E 
Sbjct:  558 IILGEKLGKGNFGEVYAGRLK----------------ASGVPVAVKACHENLSQDLKNRFLMEARILKRYNHPNVVRLIGVCTRRTPVYIVMELVRGGDFLTFLRREGSRLSVPQLLNYSEQAAAGMAYLESHNCIHRDLAARNCLVGEASVLKISDFGMSR---QQADGVYLATGVMRQIPIKWTAPEALHYGTYTTMSDVWSYGILLWEIFSLGSSPYPGWSNKMACEQVASGYRMPPPAVCPDGIYSLMLRCWEFHAEQRPTFTELHREL 811          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 91.2781 bits (225), Expect = 7.528e-19
Identity = 80/268 (29.85%), Postives = 123/268 (45.90%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMD---EVRIMASVRH-KHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLY----LENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGI-YSHKTDVWAYAVTLWEIFTFATVPY---EFLKAHEIRDEIIKGTRLRQPD---ICSLDIYILMLKCWSVDPEER 3562
            E++G+G FG VY G                + K  +V   IKVLN   D +E  D   E++ +AS++   +  R  G   K +   +I  +   GS+   L        GKI  K+   I   +L     +  +++IHRD+   NVLI  E +V++ DFG++  +N      Q   G     W+A E + +G+ Y  K D+W+  +T +EI T    PY   E L+A ++   IIK    R  D     SL  +I +  C   DP+ER
Sbjct:   27 EVIGRGKFGVVYKGY---------------NVKTGRV-YAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRP------GKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGT--PYWMAPEVIMEGVYYDTKVDIWSLGITTYEIAT-GNPPYCDVEALRAMQL---IIKSKPPRLEDRSYSTSLKEFIAL--CLDEDPKER 264          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: IPL1 (Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest [Source:SGD;Acc:S000006130])

HSP 1 Score: 84.7297 bits (208), Expect = 1.183e-17
Identity = 63/207 (30.43%), Postives = 98/207 (47.34%), Query Frame = 2
Query: 2951 QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEI---IKGTRLRQPDICSLDIYILMLKCWSVDPEER 3562
            Q +F  EV I  S+ H +  +  G  +      L+  Y+  G M K L  +       +   +  QIAN + Y+   +IIHRD+   N+LI   N +++TDFG S IINP ++  +   G   + +L+ E +    Y H  D WA  V  +E+ T A  P+E     E++D     I    ++ P   S D   L+LK    DP++R
Sbjct:  146 QKQFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHG-PFNDILASDYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGWS-IINPPENRRKTVCGT--IDYLSPEMVESREYDHTIDAWALGVLAFELLTGAP-PFE----EEMKDTTYKRIAALDIKMPSNISQDAQDLILKLLKYDPKDR 343          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 79.7221 bits (195), Expect = 2.114e-15
Identity = 49/204 (24.02%), Postives = 98/204 (48.04%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFT 3415
            +++G+G++G VY                +N   D  V +   V  +  + N+ M E+ ++ ++ H + ++  G   K  E  ++  Y   GS+ + + ++   L+      +  Q   G+ YL    +IHRD+   N+L+  +N V++ DFG+S I+N +   + + G +    W+A E L +   S  +D+W+   T+ E+ T
Sbjct:   29 QVIGRGSYGVVYKA--------------INKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSS--ALTLAGTL---NWMAPEILGNRGASTLSDIWSLGATVVEMLT 213          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 78.5666 bits (192), Expect = 3.606e-15
Identity = 63/238 (26.47%), Postives = 109/238 (45.80%), Query Frame = 2
Query: 2795 MGGEILGKGTFGSVYAG------------KWKLDNGCF----DDNSSMNS-------CKDSKVDVVIKVLNHSCDQN-------EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINP-NKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFT 3415
            + G  +G G+FGSVY G            + ++ N       D+N   NS        +  K++ V  V +   +QN           E+ ++  + H++ +   G S +G    +   Y+P GS+   L  N       ++  +  QI  G+ YL   +IIHRD+   N+LI  +  V+ITDFG+SK ++P NK + +       V W++ E ++    + K D+W+    + E+FT
Sbjct:  416 LKGACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSML-NNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFT 652          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242])

HSP 1 Score: 77.411 bits (189), Expect = 9.609e-15
Identity = 72/279 (25.81%), Postives = 121/279 (43.37%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVD-------VVIK--VLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKL-LISSYMPLGSMEKYLEKNK------KSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPY---EFLKAHEIRDEIIKGT-RLRQPDICSLDIYILMLKCWSVDPEERPNFEYL 3580
            E  G+G  GSVY      +       S+M    ++ +D       V IK  VL+    +   ++E+ +M   RHK+ +  +    +  + L ++  +M  GS+   +E +         LT   +     +   G+ +L + HIIHRD+ + NVL+     V+ITDFG    +   + +     G     W+A E ++   Y  K DVW+  +   E+      PY   + LKA  +      GT +L+ P+  SL+I   +  C  VD   R + E L
Sbjct:  550 EKAGQGASGSVYLA----ERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGT--PYWMAPEVVKQREYDEKIDVWSLGIMTIEMLE-GEPPYLNEDPLKALYLI--ATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEEL 819          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO47094 (Predicted protein; Vascular endothelial growth factor receptor-like protein [Source:UniProtKB/TrEMBL;Acc:A7RN88])

HSP 1 Score: 166.777 bits (421), Expect = 1.141e-45
Identity = 96/279 (34.41%), Postives = 148/279 (53.05%), Query Frame = 2
Query: 2807 ILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASV-RHKHCLRLIGVSYKGSEKLL--ISSYMPLGSMEKYLEKNKK---------------SLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYL 3580
            +LG G FG VY G+     G  D            + V IK L       +Q + + E++I+  V  HK+ + L+G   KG ++ L  I  +   G +  YL+K +                  T   L+  A Q+A GM +L +   IHRDLA RNVLI  +  +++ DFGL++ +  N++ ++   G+VP++W+AIE+L D IYS K+DVW+Y V LWEIFT    PY  L   ++ + ++ G R+ +P  C+ +IY +M  CW + PE+RP F  L
Sbjct:   21 LLGSGAFGQVYLGE---TEGGIDYRRPSAISMRGNIKVAIKTLKGGATESEQKDLLSELKILIHVGSHKNIVNLLGACTKGPQRDLWIILEFCANGDLLSYLKKKRDIYDPAWCAPSEDHDVQFTQMELVSAAYQVARGMEFLASRRCIHRDLAARNVLIADDYVLKVADFGLARDVYKNEEYVKHTPGLVPIKWIAIESLTDKIYSQKSDVWSYGVLLWEIFTLGGNPYPDLHPSDVFEYLLDGKRMEKPVDCAQEIYNIMTDCWVLSPEDRPTFTEL 296          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18])

HSP 1 Score: 162.54 bits (410), Expect = 2.345e-44
Identity = 93/282 (32.98%), Postives = 147/282 (52.13%), Query Frame = 2
Query: 2810 LGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNK-KSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNF----EYLWTEFKNYSNNSETYLSYPNV 3640
            LG G +G VY G WK               K +K   V  +   + +  EF+ E  +M  ++H++ ++L+GV  +     +I+ +M  G++  YL   K K L    L+  A Q+ + M YLE+ + IHRDLA RN L+   N V++ DFGLS++++ +       G   P++W A E L    +S K+DVWA+ + LWE+ T+   PY  +   ++ D++  G R+  P+ C  ++Y LM  CW  DP  RP+F    E L T F + + N   Y+SY  V
Sbjct:   20 LGGGQYGEVYEGTWK---------------KYNKTVAVKTLREETMEVEEFLKEASVMKGIKHQNLVQLLGVCTREPPFYIITEFMMNGNLLDYLRSPKGKDLDAVTLMYMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLVSEDIYTAHQ-GAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYRMPCPEGCPPEVYSLMQTCWCWDPNSRPSFKEIHEKLNTMFPSSNVNEGVYISYIKV 285          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO47097 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN91])

HSP 1 Score: 162.54 bits (410), Expect = 3.000e-44
Identity = 90/277 (32.49%), Postives = 150/277 (54.15%), Query Frame = 2
Query: 2804 EILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASV-RHKHCLRLIGVSYKGSE--KLLISSYMPLGSMEKYL---------------EKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYL 3580
            +I+G G FG V+  +     G  +   +  +CK  K +          +  + + E++I+  +  HK+ + L+G   KG E   L+I  Y P G++  +L               EK  ++ T   L+  + Q++  M +L +   +HRDLA RNVL+ +   ++I DFGL++ I   +  ++   G++PV+W+AIE L D +Y+H +DVW++ V LWEIFT    PY  L A+E+   +++G R+ QP+ C  ++Y LML+CW  DP +RP F  L
Sbjct:   20 DIVGTGAFGQVFLAE---AVGISNKQVTRVACKGLKENAT------DSEYRDLLSELKILMHIGEHKNIVNLLGACTKGRECDLLVIIEYCPHGNLLNFLRKRRDVFEATWSPPTEKPDETFTLTDLVITSFQVSRAMQFLASRRCVHRDLAARNVLVGENYVMKIADFGLARDIYKEEHYVKTTAGLLPVKWMAIEALVDQVYTHSSDVWSFGVLLWEIFTLGGSPYPGLPANEVYQYLMEGQRMAQPEDCPQEMYDLMLRCWQHDPAQRPTFTQL 287          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO47110 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNB1])

HSP 1 Score: 159.844 bits (403), Expect = 1.472e-43
Identity = 86/279 (30.82%), Postives = 155/279 (55.56%), Query Frame = 2
Query: 2810 LGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVR----HKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNK------------KSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKN 3598
            LG+G FG V  G+  ++             +++   V IK+L    D+ +  D +R +   +    H++ + LIG    G    +I+ ++  G++ + L +++              L+GK LLK A   A GM ++  N  +HRDLATRNVL+ ++   +ITDFGLS+ I  +   +   GG +P++W+A E+L D +Y+ ++D+W++ V +WE+++F  +PY  +  +E+   ++ G RL +P +C  +IY +M+ CW+ +PE RP+F  L T  ++
Sbjct:   14 LGEGEFGIVMEGELLIE-------------EEAPRKVAIKMLKSDADRTDHKDMLRELDMFKGIGQHENVVSLIGACTLGMPLYIITEFIAGGTLLELLRESRCITSSYVNANLVSKLSGKDLLKLALGAARGMRHISGNRFVHRDLATRNVLVTEDLTAKITDFGLSRDIYSDGIYLNAKGGKLPLKWMAPESLLDYVYTTQSDIWSFGVLMWEVWSFGAMPYSAVVPNELLSMLMSGFRLSRPPLCPEEIYDVMMSCWNAEPEVRPSFAKLCTVLES 279          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Match: EDO49126 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGW8])

HSP 1 Score: 160.614 bits (405), Expect = 3.539e-43
Identity = 98/338 (28.99%), Postives = 163/338 (48.22%), Query Frame = 2
Query: 2792 IMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC---DQNEFMDEVRIMASV-RHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEK------NKKSLTGKI---------LLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFG-GMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRV 3745
            I  GE++G G FG V         G  ++  ++         V +K LN      D+  F+ E+ +M  + +H + + ++G      +  LI+ Y P G +  YL         + SL G+          LL +A QIA GM YL     +HRDLA RN+LI ++N V+I+DFGL++ +  + +  ++   G +P++W+A E +   +++ K+DVWA+ V LWEI T    PY      E   ++  G R+ +PD+CS ++Y +M  CW+  PE+RP F  L  + +   +  +                   YI++   + E SY A  S +  R+
Sbjct:   18 IAFGEVVGSGAFGKVTKATIVGLPGGPENKETV---------VAVKKLNAMATMEDRRNFLSEIEMMKQLGKHLNIVSILGCVTHAGQLCLITEYCPYGDLRNYLRAIRDKVSTRDSLAGRAPGRELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVYESSEYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKEFYKKLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKLRNQLEQLMDREDEL-----------------YIDVNFEDAEYSYLATDSSSSGRL 329          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: egfra (epidermal growth factor receptor [Source:NCBI gene;Acc:101159776])

HSP 1 Score: 255.373 bits (651), Expect = 1.206e-69
Identity = 157/470 (33.40%), Postives = 235/470 (50.00%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGK-CHPCHPQCNGCYGV----DKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGN------SNENICVFVF---LSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDK-LKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C  C+ Y    +CV  C      L+ +   + + K C  C P+C    G        +C  C NF+           CV  CP                  N+C         G   + +I A V   +L  L   ++ F L R+   KR + ++         +  TPS   PN   L ++     + I   ++LG G FG+VY G W  +             +D K+ V IKVL  +       E +DE  +MASV + H  RL+G+    + +L I+  MP G +  Y+++ K ++  + LL W  QIA GM YLE  H++HRDLA RNVL+   NHV+ITDFGL+K++N ++ E    GG VP++W+A+E++    Y+H++DVW+Y VT+WE+ TF T PY+ + A EI   + KG RL QP IC++D+Y++M+KCW +D E RP F  L  EF   + +   YL
Sbjct:  440 CFACRDYSRGGRCVDSC----NILEGEPREAVMNKTCVECDPECQRMNGTATCSGPGNCAKCANFQ-------DGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQGSTGLSMIAAGVVGGLLTVLVTGLSVFVLLRRRYIKRKRTMRRLLQERELVEPLTPSGQAPNQALLRILKESEFKKI---KVLGSGAFGTVYKGLWVPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYVMASVENPHVCRLLGICLTSTVQL-ITQLMPYGCLLDYVKEKKDNIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPNHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESILTRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGDRLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIGEFTKMARDPSRYL 882          

HSP 2 Score: 136.732 bits (343), Expect = 5.697e-32
Identity = 123/457 (26.91%), Postives = 190/457 (41.58%), Query Frame = 2
Query:  671 KKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPP--KKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYE-RQGD--QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK-----TCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKIT---------KTCEPCHKDCHSRS 1978
            KKC     +G CW P    CQ  +K    + C+ RC      D  CCN  C  GCT    + C+AC+   D+ VC+  CP   +   N    +P PN  +   F   C+  CP   ++   G C   C+   YE  +G   +C  C   C ++C         +  ++  S++   +    NCT   G +     S    +    P  +   L   + ++ I+G  Y+ ++  P  + SLS   NL+ I       S S+ I   DISYLGL+SLK I +  +    N  LCY +   +K + K+ T    T+++              + C  +C +  GCWGPGP+ C +C +   G  C ++C +  G        +K C++C  EC +     TCSG     C   C +  +   CV  C +       T           C+ CHK+C   S
Sbjct:  119 KKCHSSCFNGSCWAPGPQYCQTLTKLNCAQQCSKRCKGPSPSD--CCNEHCAAGCTGPRPTDCLACRDFRDDGVCKDSCPGLMRYDPNLHLLVPNPNGKYS--FGATCVKNCPHNYVVTDHGACVRTCSGNTYEVDEGGIRKCAKCNGPCPKVC---NGLGTGNLTHT-LSINATNIDSFKNCTKINGNIAFIHTSIYGDKFTKTPKMDPAKLDVFKTVKEITG--YLWIQTWPKNMSSLSPFENLEIIRGRTKQGSRSVAITQLDISYLGLRSLKEISDGDVVIIKNHNLCYTNRSHWKGLFKSKT---QTLMN--------------STCDRKCAAD-GCWGPGPDMCFACRDYSRGGRCVDSCNILEGE-PREAVMNKTCVECDPECQRMNGTATCSG--PGNC-AKCANFQDGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQGS 543          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: ENSORLT00000004471.2 (melanoma receptor tyrosine-protein kinase [Source:NCBI gene;Acc:101169984])

HSP 1 Score: 252.292 bits (643), Expect = 5.181e-68
Identity = 185/649 (28.51%), Postives = 295/649 (45.45%), Query Frame = 2
Query: 2183 IVILEPCHDLCSQCTIRTDQRISLSKTDW----KGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC------NGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN-----------YKETSGNSN------ENICVFVFLSG-XXXXXXXXXXXXXXXXXXXXXXXTKFCLA---RKGKRKRDKLKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL----SYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEH--VQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSN----GNTNYHDFHSRPDVSPSSLTIEYLEP 3991
            IV   P  D+C       DQ+ S SK  W      C  C+ +     CV  C  ++   +  E     G C  CHP+C        C+G   + C  C +FK   +       CV  CP             Y + +G            C    LSG           V +     + +I+  F L    R+  +K+  L+         +  TPS   PN   L ++     + +    +LG G FG+V+ G W  +             ++ ++ V IKVL  +       E +DE  +MASV H H  RL+G+    S +L ++  MP G +  Y+ ++K  +  + LL W  QIA GM YLE  H++HRDLA RNVL+   NH++ITDFGL+K++  ++ E    GG VP++W+A+E++    Y+H++DVW+Y VT+WE+ TF + PY+ + A EI   + +G RL QP IC++D+Y++M+KCW +DP  RP F+ L  EF   + +   YL      P+   +   +   +  ++++  D   Y  P     N+  +  +  P G     +V E+    R++  P    L  + +   +  N +++ +   S      N NY D       +   L+ E LEP
Sbjct:  510 IVDQTPPVDVCEGQNQTCDQQCS-SKGCWGPGTNMCLSCQYFNRKQHCVERCNLLQGEPREVEVE---GSCVECHPECLVMTGTQTCHGPGPDQCSQCAHFKDGSH-------CVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQGCSGPGLSGCSRTTTHSSLAVGVVSGLLVAVIVLLFVLVYVRRQRIKKKRTLRRLLQEKELVEPLTPSGQAPNQALLRILKETEFKKV---RVLGSGAFGTVFKGLWVPEG------------ENVRIPVAIKVLREATSPKANQEVLDEAYVMASVDHPHVCRLLGICLTSSVQL-VTQLMPYGCLLDYVRQHKDRICAQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHIKITDFGLAKLLTADEKEYHADGGKVPIKWMALESILQWTYTHQSDVWSYGVTVWELMTFGSKPYDGIAASEIATVLERGERLPQPPICTIDVYMIMVKCWMIDPSSRPKFKELIMEFSQMARDPSRYLVIRGDLPSPSDSRFFSRLLSSDDMEEIADADEYLLP-----NKRLIPPDSHPCGATNGHLVRENSGALRYITDPTQSGLDKDDIFGHEYMNQSVSETSRSSRLSEVLNPNYEDLSLASSTASLHLSPENLEP 1126          

HSP 2 Score: 183.341 bits (464), Expect = 2.487e-46
Identity = 166/649 (25.58%), Postives = 290/649 (44.68%), Query Frame = 2
Query:  167 SSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQ-FCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSK--CRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETG--IPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGD---QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIIST-SLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDEC-----AKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNK---ITK------TCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNK 2041
            S++  L G++  +Y ++ + + +NC+ V  N+ I            DL FL  I+E+ G + I  +++++VPL NLR+IRG + LY   ++  + N    +I      ++ ++  + L  L  I++G + +++     ++  ++W ++++     SV  K       C ++C     +  CW      CQ F+K  C ++    RC  S     +CCN  C  GCT   ++ C+AC+   D+ +C+  CPP  + N ++   +  PN  +   F   C+  CP   +  EG C   C+   YE + +   +C  C+  C + C    +    +      +++   ++   NCT   G +     SF   +   +P  +   L++   ++ I+G + I  +  P  + SLS   NL+ I      ++  S  ++  D + +LGL+SLK +    +  K+N  LCY     +  + +  T     I+      D  +CE +   C  QC S+ GCWGPG N C+SC        C E C +  G     +     C++CH EC      +TC G   DQC   C H  + S CVR C      ++   I K       C+ CH++C          C+G    PG  GC++
Sbjct:   50 SNLLTLLGTREYHYESMVR-MYSNCSVVLENLEITYTLENQ-----DLSFLQSIQEVGGYVLIAMNDVATVPLVNLRLIRGQN-LYDKFALLVMSNYHSNNITGAPRYTSGLRQ-LQLSRLTEILNGGVKVTNNPLLCNMEKIQWWDIVDKARNFSVLLKFDDYKRDC-ERCDPGCVNDSCWAAGPDHCQKFTKLVCAEQCGPGRC--SGPKPLDCCNQHCAAGCTGPLATDCLACKNFNDDGICKDSCPPLNLYNHKSQQVVENPNAKYS--FGATCVKACPHNYVVTEGSCVRACSPNTYEVEENGVQRCKRCEGPCPKACDGVGVGRLTN----TIAVNSSNIESFRNCTKINGDIVFLKSSFSGDQHYNIPPMDPKKLEYFRTVKEITGHLLI--QTWPENMTSLSVFENLEIIRGRSLFVNKYSFVVVGADNLHWLGLRSLKELSAGNVRLKDNKLLCYSKAMNWSYLFRDKT----QIVDQTPPVD--VCEGQNQTCDQQCSSK-GCWGPGTNMCLSCQYFNRKQHCVERCNLLQGEPREVEVEGS-CVECHPECLVMTGTQTCHGPGPDQC-SQCAHFKDGSHCVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQG-------CSG----PGLSGCSR 659          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: egfra (epidermal growth factor receptor [Source:NCBI gene;Acc:101159776])

HSP 1 Score: 251.521 bits (641), Expect = 9.400e-68
Identity = 128/331 (38.67%), Postives = 191/331 (57.70%), Query Frame = 2
Query: 2651 FCLARKGKRKRDK-LKAYFSNANESDSQTPS--PPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCD---QNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            F L R+   KR + ++         +  TPS   PN   L ++     + I   ++LG G FG+VY G W  +             +D K+ V IKVL  +       E +DE  +MASV + H  RL+G+    + +L I+  MP G +  Y+++ K ++  + LL W  QIA GM YLE  H++HRDLA RNVL+   NHV+ITDFGL+K++N ++ E    GG VP++W+A+E++    Y+H++DVW+Y VT+WE+ TF T PY+ + A EI   + KG RL QP IC++D+Y++M+KCW +D E RP F  L  EF   + +   YL
Sbjct:  658 FVLLRRRYIKRKRTMRRLLQERELVEPLTPSGQAPNQALLRILKESEFKKI---KVLGSGAFGTVYKGLWVPEG------------EDVKIPVAIKVLREATSPKANKEILDEAYVMASVENPHVCRLLGICLTSTVQL-ITQLMPYGCLLDYVKEKKDNIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPNHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESILTRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGDRLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIGEFTKMARDPSRYL 972          

HSP 2 Score: 174.096 bits (440), Expect = 2.085e-43
Identity = 163/634 (25.71%), Postives = 265/634 (41.80%), Query Frame = 2
Query:  182 LDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELL---EDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCR-KRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPP--KKIINRETGIPEPNKYFRPLFVNICLNKCPEG-LLEQEGECKTQCTFRKYE-RQGD--QCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK-----TCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKIT---------KTCEPCHKDCHSRSITRLPVCTGPS 2011
            L GS+  +Y  + +   +NCT V  N+ I  + +       DL FL  I+E+ G + I  +  + +PL NLR+IRG S      ++  L NS + +   ++ ++              I++G I   +    ++  ++W +++   + P  +       P   KC   C     +G CW P    CQ  +K    + C+ RC      D  CCN  C  GCT    + C+AC+   D+ VC+  CP   +   N    +P PN  +   F   C+  CP   ++   G C   C+   YE  +G   +C  C   C ++C         +  ++  S++   +    NCT   G +     S    +    P  +   L   + ++ I+G  Y+ ++  P  + SLS   NL+ I       S S+ I   DISYLGL+SLK I +  +    N  LCY +   +K + K+ T +    + +N  A    C    + C  +C +  GCWGPGP+ C +C +   G  C ++C +  G        +K C++C  EC +     TCS      C   C +  +   CV  C +       T           C+ CHK+C          CTGP 
Sbjct:   35 LLGSKDDHYLNMVKTY-SNCTVVLENLEITYMDNNH-----DLSFLKSIEEVGGYVLIALNTATRIPLENLRIIRGHSLYEGEFALSVLVNSDKGTGTTELLLTKL----------TEILAGGIKFGNNQLCNVETIQWFDIVNPDKKPKMELPMASNNPLCKKCHSSCF----NGSCWAPGPQYCQTLTKLNCAQQCSKRCKGPSPSD--CCNEHCAAGCTGPRPTDCLACRDFRDDGVCKDSCPGLMRYDPNLHLLVPNPNGKYS--FGATCVKNCPHNYVVTDHGACVRTCSGNTYEVDEGGIRKCAKCNGPCPKVCN---GLGTGNLTHT-LSINATNIDSFKNCTKINGNIAFIHTSIYGDKFTKTPKMDPAKLDVFKTVKEITG--YLWIQTWPKNMSSLSPFENLEIIRGRTKQGSRSVAITQLDISYLGLRSLKEISDGDVVIIKNHNLCYTNRSHWKGLFKSKTQS--ANVDENASA--TACALMNSTCDRKCAAD-GCWGPGPDMCFACRDYSRGGRCVDSCNILEGE-PREAVMNKTCVECDPECQRMNGTATCSASGPGNC-AKCANFQDGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQG-------CTGPG 624          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: erbb4b (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:101165111])

HSP 1 Score: 251.906 bits (642), Expect = 1.247e-67
Identity = 152/482 (31.54%), Postives = 244/482 (50.62%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCN-------GCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN--------YKETSGNSNENICVFVFLSG-------------XXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C  CK +     C+  C   +  ++ +  N S+  C  C  QC         C+G    HC+ C +FK   N       CVE CP          +K    N+  + C      G                 L+   V+    +  +  +     + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ I   +ILG G FG+VY G W            +   +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL+++++ N+ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   +I D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  477 CLSCKFFSRGRSCIKSCNLYQGEIR-EYANGSV--CVECDSQCEQGDDNTLTCHGSGPEHCVKCLHFKDGPN-------CVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIGWMDRTPLIAAGVIGGLFMVVIMALSVAVSVRRKNIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIW------------IPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLDVNEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFTRMARDPQRYL 932          

HSP 2 Score: 160.614 bits (405), Expect = 3.336e-39
Identity = 160/624 (25.64%), Postives = 260/624 (41.67%), Query Frame = 2
Query:  206 YNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKS--GFCWGPLTSQCQIFSKCRKRMCANRCFLSETGD--EECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSI-TRLPVCTG 2005
            Y TL++    NC  V GN+ I ++    N     L FL  I+E+TG + +  +    +PL NLR+IRG ++LY  +   +L        D +  + +     + L +L  I+ G +Y+  ++F      + W +++++P    V       PT  S  C +  +S  G CWGP  +QCQ  +K    +CA +C    +G    +CC+ +C GGC     + C AC    D+  C  +CP     N  T   E N   R  +   C+ KCP                           PC  +        +            ++D   + K  NCT   G   F+    +  V H  E +   + + L    ++R I+G  Y++++  P  +  L   SNL  I         SL ++    IS   L+SLK I    +    N +LCY++   +  + ++   N   ++ +N   +P  C +   VC   C S  GCWG GP+ C+SC     G  C ++C +  G +    +   VC++C  +C +      TC G   + C+  C H  +   CV +C       + F+ K  +    C PCH +C    I  RL  C G
Sbjct:   42 YRTLRKYY-ENCEVVMGNLEITSIDRSRN-----LTFLRSIREVTGYVLVALNQFDHLPLENLRIIRG-TKLY--EDRYSLAIFLNYRRDGNFGLRH-----LGLINLAEILYGGVYVDQNKFLCHADTIHWQDIVKNPGFHPVV-----VPTNSSVTCPKCHRSCNGRCWGPKDNQCQSLTKT---VCAEQCDGRCSGPYVSDCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFFYNPTTFQLEHNPSARYTYGAFCVKKCP---------------------------PCDGIGTGTLQAAQ------------TVDSSNIDKFVNCTKINGNLVFLITGIKGDVYHNIEAL---DPEKLNVFRSVREITG--YLNIQSWPDNMTDLIVFSNLATIGGRALYSGISLLVLKQQGISSFLLQSLKEISAGNVHIAENKQLCYYNTVNWTRLFRSP--NQKVLVRNN--RNPLECARGHMVCDPLC-SDDGCWGSGPDQCLSCKFFSRGRSCIKSCNLYQGEIRE-YANGSVCVECDSQCEQGDDNTLTCHGSGPEHCV-KCLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIG 592          
BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Match: erbb4b (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:101165111])

HSP 1 Score: 252.292 bits (643), Expect = 1.366e-67
Identity = 152/482 (31.54%), Postives = 244/482 (50.62%), Query Frame = 2
Query: 2276 CTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCN-------GCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSN--------YKETSGNSNENICVFVFLSG-------------XXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYF-SNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQN---EFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYL 3625
            C  CK +     C+  C   +  ++ +  N S+  C  C  QC         C+G    HC+ C +FK   N       CVE CP          +K    N+  + C      G                 L+   V+    +  +  +     + RK  +K+  L+ +  +   E  + + + PN   L ++    L+ I   +ILG G FG+VY G W            +   +  K+ V IK+LN +       EFMDE  IMAS+ H H +RL+GV    + +L ++  MP G +  Y+ ++K ++  ++LL W  QIA GM+YLE   ++HRDLA RNVL+   NHV+ITDFGL+++++ N+ E    GG +P++W+A+E +    ++H++DVW+Y VT+WE+ TF   PY+ +   +I D + KG RL QP IC++D+Y++M+KCW +D + RP F+ L  EF   + + + YL
Sbjct:  515 CLSCKFFSRGRSCIKSCNLYQGEIR-EYANGSV--CVECDSQCEQGDDNTLTCHGSGPEHCVKCLHFKDGPN-------CVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIGWMDRTPLIAAGVIGGLFMVVIMALSVAVSVRRKNIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRI---KILGSGAFGTVYKGIW------------IPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQL-VTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLDVNEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFTRMARDPQRYL 970          

HSP 2 Score: 184.111 bits (466), Expect = 2.081e-46
Identity = 167/627 (26.63%), Postives = 274/627 (43.70%), Query Frame = 2
Query:  206 YNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYI-SSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKS--GFCWGPLTSQCQIFSKCRKRMCANRCFLSETGD--EECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQ---CVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKG---FVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTD-ISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAK------TCSGLRSDQCIGGCKHAMENSMCVREC-----SRTHFLNKITKT---CEPCHKDCHSRSI-TRLPVCTG 2005
            Y TL++    NC  V GN+ I ++    N     L FL  I+E+TG + +  +    +PL NLR+IRG ++LY  +   +L        D +  + +     + L +L  I+ G +Y+  ++F      + W +++++P    V       PT  S  C +  +S  G CWGP  +QCQ  +K    +CA +C    +G    +CC+ +C GGC     + C AC    D+  C  +CP     N  T   E N   R  +   C+ KCP   +     C   C   K E + +    C+PC  +C + C   +       + +  ++D   + K  NCT   G   F+    +  V H  E +   + + L    ++R I+G  Y++++  P  +  L   SNL  I         SL ++    IS   L+SLK I    +    N +LCY++   +  + ++   N   ++ +N   +P  C +   VC   C S  GCWG GP+ C+SC     G  C ++C +  G +    +   VC++C  +C +      TC G   + C+  C H  +   CV +C       + F+ K  +    C PCH +C    I  RL  C G
Sbjct:   42 YRTLRKYY-ENCEVVMGNLEITSIDRSRN-----LTFLRSIREVTGYVLVALNQFDHLPLENLRIIRG-TKLY--EDRYSLAIFLNYRRDGNFGLRH-----LGLINLAEILYGGVYVDQNKFLCHADTIHWQDIVKNPGFHPVV-----VPTNSSVTCPKCHRSCNGRCWGPKDNQCQSLTKT---VCAEQCDGRCSGPYVSDCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFFYNPTTFQLEHNPSARYTYGAFCVKKCPHNFVVDHNSCVRACPTNKMEVEDNHIKMCIPCTDICPKAC---DGIGTGTLQAAQ-TVDSSNIDKFVNCTKINGNLVFLITGIKGDVYHNIEAL---DPEKLNVFRSVREITG--YLNIQSWPDNMTDLIVFSNLATIGGRALYSGISLLVLKQQGISSFLLQSLKEISAGNVHIAENKQLCYYNTVNWTRLFRSP--NQKVLVRNN--RNPLECARGHMVCDPLC-SDDGCWGSGPDQCLSCKFFSRGRSCIKSCNLYQGEIRE-YANGSVCVECDSQCEQGDDNTLTCHGSGPEHCV-KCLHFKDGPNCVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIG 630          
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1)

HSP 1 Score: 2568.5 bits (6656), Expect = 0.000e+0
Identity = 1300/1317 (98.71%), Postives = 1303/1317 (98.94%), Query Frame = 2
Query:   56 MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
            MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINT+ISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVD NHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSG EL LVILAVVF+FV+ TLF IITKFC AR GKRKRDKLKAYFSNA ESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNY TNTFNNYIEIKQHEDEISY APHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFL  PPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI
Sbjct:    1 MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYKTNTFNNYIEIKQHEDEISYDAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLTEPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 1317          
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1)

HSP 1 Score: 2517.27 bits (6523), Expect = 0.000e+0
Identity = 1279/1323 (96.67%), Postives = 1287/1323 (97.28%), Query Frame = 2
Query:   77 WIYLHILLISLIFY-------------RYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYTTNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 4006
            +   H+L++S   Y               + SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINT+ISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVD NHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSG EL LVILAVVF+FV+ TLF IITKFC AR GKRKRDKLKAYFSNA ESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNY TNTFNNYIEIKQHEDEISY APHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFL  PPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI
Sbjct:    3 FTLFHLLILSKFIYFGDSKPNATDTSQSLTYSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYKTNTFNNYIEIKQHEDEISYDAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLTEPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTRI 1325          
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1)

HSP 1 Score: 1768.05 bits (4578), Expect = 0.000e+0
Identity = 916/929 (98.60%), Postives = 919/929 (98.92%), Query Frame = 2
Query:   56 MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA 2842
            MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINT+ISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVD NHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSG EL LVILAVVF+FV+ TLF IITKFC AR GKRKRDKLKAYFSNA ESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA
Sbjct:    1 MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA 929          
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1)

HSP 1 Score: 1717.98 bits (4448), Expect = 0.000e+0
Identity = 895/935 (95.72%), Postives = 903/935 (96.58%), Query Frame = 2
Query:   77 WIYLHILLISLIFY-------------RYSDSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA 2842
            +   H+L++S   Y               + SLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINT+ISYLGLKSLK IKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTI TDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVD NHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSG EL LVILAVVF+FV+ TLF IITKFC AR GKRKRDKLKAYFSNA ESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA
Sbjct:    3 FTLFHLLILSKFIYFGDSKPNATDTSQSLTYSLIEYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVPIISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQTPSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYA 937          
BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Match: SMESG000016935.1 (SMESG000016935.1)

HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0
Identity = 436/1365 (31.94%), Postives = 666/1365 (48.79%), Query Frame = 2
Query:   86 LHILLISLIFY-----RYSDSLIEYPEIKYCFSSM---DLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSL--ANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQK-----GKSG----FCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCK-----------ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP--IISTSLTIINTDISYLGLKSLXXXXXXXXXXXXXXXLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKV-CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHF--LNKITK--TCEPCHKDCHSRS--ITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFXXXXXXXXXXXXXXFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC-NGC-YGVDKNHCIHCNNFKLPENENLTLFSCVESCPSNYK--------------ETSGNSNENICVFVFLSGXXXXXXXXXXXXXXXXXXXXXXXTKFCLARKGKRKRDKLKAYFSNANESDSQT------PSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC--DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--VEQNYTTNT-FNNYIEIKQ---------------HEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLNGPPIRNLLYEPV-NFSKTS-NITLNGSFNKSNGNTNYH 3931
            +H+LL  ++ +       S+   +YP  + C  S         +++  Y      LG  CTH+YGN+ I+++    NGS+PDL FL  I EI+GSL I N+++  +PL NL+VIRG +     D++  + N  E         + +    IDLR+LR+I+S N+ IS          N++W+++L+DPT Q +      +P+  + KC  +     G+ G    FC+GP  ++CQ  +KC K      C  ++TG E  C+ +C GGC    S  C  C  ++ ++ C   C P+   N   G+   +K  R     +C ++CP  LL+Q   C  +C F  +++ G++C+ C             LC  + T+++ +  N+ KY   SL+   L +L NCT   G + ID  SF K+   +  + +      L+N+R I G     L     K+ +L+FLSNL+ I   V    +++++ I    I +LGLK LK +  K      N   CY D   ++ I   + +      S N   DP        +C+ Q      CWGPG   C SCA  + G  C + C   PGY  +      + C  CH  C + C+G     C G C++A+E + CV+ CS   F   N +    TC+ CH  C      +     CTGPSN  G GGC+KC+ +I   + Q   C++ +   G++        S  H   + + +      EPCH +C  C+  T+++        + C QCKGY+ D+KCV  C  ++      E      +C  CH +C NGC    D   C  C N KL  +++   FSCV  CP +                E + NS +   +F+ LSG    LV +    +            F       R   ++KA +SN  E D +         PPNM  + +I   +L F    + LG G FG VY G WK+      DN  +N      ++VVIKV+++S     +EF++E +IMASV H+HCL LIGV     +  L+S+Y   GS++KYL++N K ++   +LKWA+QIA+GM YL    IIHRDLA RNVL+  ++++QITDFGL+++++   D + I  G VP+RWLAIETL    YS  TDVWAY VTLWEIFT+A  PYE L   EI+  + +G RL QP+I +L++Y++M+KCW  DP  RP+F  L + F+ +  + + +L  P+  V Q Y  +      I++ Q                 DE S+ A    N +   +I N   + + KS +      +       RN+  E + NFSK   N  L+   ++ + N NY 
Sbjct:    1 MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYKYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSE---------NGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTGEDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTG-EIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP--NHIFGMDSKDK-LRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLC-NLATIDKFYPKNNRKY---SLNKQTLMQLTNCTLILGDLDIDDISFNKNGVTVPMLYH-----HLKNVREIIG--LFSLVTFRTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFLGLKKLKKVYGKISIGGTNGT-CYLDRIPWEEISPDNRVK----FSCNKTCDP--------LCTGQ------CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTSNNQY-LCHKGSCPKGFYQSVINQNISHLHKKIVHQSS-----CEPCHSMCRTCSGPTNEK--------RMCHQCKGYFLDNKCVKECDNMKNVTMKLEIGD---ECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLY----------FRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPR---QDNKYIN------LEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAK-------RNISLERIKNFSKLDLNKILSPKSHRESKNFNYQ 1279          
The following BLAST results are available for this feature:
BLAST of epidermal growth factor receptor 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ERBB44.523e-6931.47erb-b2 receptor tyrosine kinase 4 [Source:HGNC Sym... [more]
ERBB44.717e-6931.47erb-b2 receptor tyrosine kinase 4 [Source:HGNC Sym... [more]
ERBB47.211e-6931.47erb-b2 receptor tyrosine kinase 4 [Source:HGNC Sym... [more]
ERBB21.646e-6431.29erb-b2 receptor tyrosine kinase 2 [Source:HGNC Sym... [more]
ERBB21.671e-6431.34erb-b2 receptor tyrosine kinase 2 [Source:HGNC Sym... [more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
let-234.813e-12028.52Receptor tyrosine-protein kinase let-23 [Source:U... [more]
let-235.468e-12028.31Receptor tyrosine-protein kinase let-23 [Source:U... [more]
let-233.359e-11928.52Receptor tyrosine-protein kinase let-23 [Source:U... [more]
let-233.438e-11928.52Receptor tyrosine-protein kinase let-23 [Source:U... [more]
R151.16.738e-4633.33pep chromosome:WBcel235:III:7218813:7221186:1 gene... [more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Egfr1.097e-14829.25gene:FBgn0003731 transcript:FBtr0071654[more]
Egfr1.676e-14829.24gene:FBgn0003731 transcript:FBtr0071653[more]
Shark4.590e-5337.58gene:FBgn0015295 transcript:FBtr0087244[more]
Btk29A6.199e-4734.69gene:FBgn0003502 transcript:FBtr0330693[more]
Btk29A1.010e-4634.69gene:FBgn0003502 transcript:FBtr0330692[more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egfra1.080e-6834.26epidermal growth factor receptor a (erythroblastic... [more]
si:ch73-383l1.11.250e-6738.72si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-6... [more]
erbb4a8.851e-6736.39erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Ac... [more]
erbb4a1.531e-6631.17erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Ac... [more]
si:ch73-383l1.11.800e-6629.67si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-6... [more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ERBB42.776e-7232.02erb-b2 receptor tyrosine kinase 4 [Source:NCBI gen... [more]
ERBB49.055e-7232.40erb-b2 receptor tyrosine kinase 4 [Source:NCBI gen... [more]
ERBB41.034e-7132.02erb-b2 receptor tyrosine kinase 4 [Source:NCBI gen... [more]
ERBB41.044e-7132.02erb-b2 receptor tyrosine kinase 4 [Source:NCBI gen... [more]
ERBB41.296e-7132.02erb-b2 receptor tyrosine kinase 4 [Source:NCBI gen... [more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Erbb47.266e-7030.88erb-b2 receptor tyrosine kinase 4 [Source:MGI Symb... [more]
Erbb47.562e-7030.88erb-b2 receptor tyrosine kinase 4 [Source:MGI Symb... [more]
Egfr3.557e-6628.62epidermal growth factor receptor [Source:MGI Symbo... [more]
Erbb27.520e-6330.57erb-b2 receptor tyrosine kinase 2 [Source:MGI Symb... [more]
Erbb32.387e-5836.46erb-b2 receptor tyrosine kinase 3 [Source:MGI Symb... [more]
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BLAST of epidermal growth factor receptor 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P04412|EGFR_DROME4.575e-14328.92Epidermal growth factor receptor OS=Drosophila mel... [more]
sp|P0CY46|EGFR_APIME1.811e-14032.00Epidermal growth factor receptor OS=Apis mellifera... [more]
sp|P24348|LET23_CAEEL6.956e-11928.31Receptor tyrosine-protein kinase let-23 OS=Caenorh... [more]
sp|Q62956|ERBB4_RAT9.407e-7131.49Receptor tyrosine-protein kinase erbB-4 OS=Rattus ... [more]
sp|Q61527|ERBB4_MOUSE5.082e-6930.88Receptor tyrosine-protein kinase erbB-4 OS=Mus mus... [more]
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BLAST of epidermal growth factor receptor 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1B1ACY30.000e+099.38Receptor protein-tyrosine kinase (Fragment) OS=Sch... [more]
F6KBQ50.000e+099.50Epidermal growth factor receptor 1 (Fragment) OS=S... [more]
A0A0X3PH980.000e+031.19Receptor protein-tyrosine kinase OS=Schistocephalu... [more]
A0A0X3Q4X90.000e+031.19Receptor protein-tyrosine kinase OS=Schistocephalu... [more]
A0A0X3P0D00.000e+030.96Receptor protein-tyrosine kinase OS=Schistocephalu... [more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egfra5.472e-7229.71epidermal growth factor receptor-like [Source:NCBI... [more]
egfra1.661e-7029.51epidermal growth factor receptor-like [Source:NCBI... [more]
ENSAMXT00000016431.23.166e-6839.18epidermal growth factor receptor-like [Source:NCBI... [more]
erbb4b6.477e-6830.72erb-b2 receptor tyrosine kinase 4b [Source:ZFIN;Ac... [more]
ENSAMXT00000051131.16.700e-6839.18epidermal growth factor receptor-like [Source:NCBI... [more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000003172.15.084e-7232.68pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 ge... [more]
ENSPMAT00000005822.12.531e-5142.70pep scaffold:Pmarinus_7.0:GL476959:64997:68848:-1 ... [more]
EGFR9.915e-4629.63epidermal growth factor receptor [Source:HGNC Symb... [more]
ENSPMAT00000010487.13.088e-4326.56pep scaffold:Pmarinus_7.0:GL501102:818:30108:-1 ge... [more]
fer2.287e-4234.43fer (fps/fes related) tyrosine kinase [Source:ZFIN... [more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
KIC17.528e-1929.85Protein kinase of the PAK/Ste20 family, required f... [more]
IPL11.183e-1730.43Aurora kinase of chromosomal passenger complex; me... [more]
CDC152.114e-1524.02Protein kinase of the Mitotic Exit Network; locali... [more]
STE113.606e-1526.47Signal transducing MEK kinase; involved in pheromo... [more]
CLA49.609e-1525.81Cdc42p-activated signal transducing kinase; member... [more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO470941.141e-4534.41Predicted protein; Vascular endothelial growth fac... [more]
EDO471952.345e-4432.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO470973.000e-4432.49Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO471101.472e-4330.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO491263.539e-4328.99Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of epidermal growth factor receptor 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egfra1.206e-6933.40epidermal growth factor receptor [Source:NCBI gene... [more]
ENSORLT00000004471.25.181e-6828.51melanoma receptor tyrosine-protein kinase [Source:... [more]
egfra9.400e-6838.67epidermal growth factor receptor [Source:NCBI gene... [more]
erbb4b1.247e-6731.54erb-b2 receptor tyrosine kinase 4 [Source:NCBI gen... [more]
erbb4b1.366e-6731.54erb-b2 receptor tyrosine kinase 4 [Source:NCBI gen... [more]
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BLAST of epidermal growth factor receptor 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000070834.10.000e+098.71SMESG000070834.1[more]
SMESG000070834.10.000e+096.67SMESG000070834.1[more]
SMESG000070834.10.000e+098.60SMESG000070834.1[more]
SMESG000070834.10.000e+095.72SMESG000070834.1[more]
SMESG000016935.10.000e+031.94SMESG000016935.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30009712
GenBankAEE89453.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30009712 ID=SMED30009712|Name=epidermal growth factor receptor 1|organism=Schmidtea mediterranea sexual|type=transcript|length=4149bp
ATCTGTATTAATTGCATCGATCATGTATTTGATTGACAAATCTACTTTTT
GAGTTATGCTTTATCTTTCTTACTGTTGGATTTATTTACATATTTTATTG
ATTTCATTGATTTTCTATCGGTATTCAGATTCATTAATCGAATATCCAGA
AATTAAATATTGTTTCAGCAGCATGGATTTATTGGATGGCAGTCAGTCTT
CTAATTATAATACTTTGAAACAAGATTTGGGCAACAACTGTACACACGTG
TATGGGAATATTTTCATAAATAATGTCAAAAGTGAAAGTAATGGTTCGGA
ACCAGATTTAGAGTTTCTATCAGGAATTAAAGAAATAACTGGTTCATTGA
AGATCCGAAATTCAAATATCTCTAGTGTTCCTTTGCGAAATTTGCGGGTG
ATTCGTGGAGATTCTAGACTATATACTCACGATTCAATGGGGGCTCTTCA
AAATTCTTTTGAAGTCAGTATAGATCAAGATATATCGGTATCAAATTCGA
TCAAAACAGTTATTGATTTACGATCTCTGCGCAGTATTGTTAGCGGTAAT
ATTTACATATCTTCTCAATTCTGTTCCAGTCTGGCTAATGTGGAATGGAA
CGAATTACTTGAAGATCCGACTCGACAATCCGTAACCGGAAAATGCACCC
CTCAGCCAACAAAATGTTCTAAAAAATGTATGCAAAAAGGAAAATCAGGA
TTTTGCTGGGGACCTTTGACTAGTCAGTGTCAAATATTTTCAAAGTGTCG
AAAGCGAATGTGTGCAAATAGATGTTTTCTGTCCGAAACTGGAGATGAAG
AATGTTGCAATTCGCAATGTTTAGGAGGTTGTACATCTAGTGACTCTAGT
TCTTGCATTGCTTGTCAAGGAGTTCTTGACAATAATGTTTGTCAACCTGA
ATGTCCACCAAAGAAAATTATCAATCGGGAAACGGGGATTCCAGAACCTA
ATAAATATTTTCGACCTCTTTTTGTAAATATATGCCTAAATAAATGTCCA
GAAGGTTTATTAGAGCAGGAAGGAGAATGTAAAACACAATGTACCTTTAG
AAAATATGAGCGTCAAGGAGATCAATGTGTACCATGCAAAATATTATGCG
AGCAAATTTGTACACTCGAAGAAATATTTAGTCCAAATGATTTCAAATAT
TCTTACTTTTCACTGGACTACCCAAAGTTAAAAAAGTTAGCAAATTGCAC
CACTTTTAAAGGCTTCGTACAGATTGACACTGAATCTTTTGTTAAACACA
GGCCGGAAATCGTACCCATTTCAAATTCAGATGATTTAAAATTTTTAGAA
AACCTCCGTAACATTTCAGGAAGTGTTTATATTGACTTAAAAGATGCTCC
TTTCAAATTGGATAGTCTTTCATTTTTAAGTAATTTGCAAGCAATTGAAA
GCCTGGTACCAATCATATCAACCAGCTTAACCATAATAAATACCGATATC
AGTTATCTTGGTCTCAAAAGTTTGAAAATTATTAAGAATAAAGCAATATT
CTTTAAGAATAATACCAAACTTTGTTATTTTGATATTAAAAAATTTAAAA
ACATTGTCAAAACAGATACCTTAAATGATGTTACTATAATATCTGATAAC
GGAATGGCAGATCCCAAATTGTGTGAACAACGAGGAAATGTATGCAGTGT
TCAATGCGATTCTCAACTTGGTTGTTGGGGACCTGGTCCAAATCACTGTA
TTTCTTGTGCGAATGTAAGATTAGGTACGATTTGCGCAGAAAACTGTTTA
GTGCAACCGGGATATCTAACCAATCCTGATTCAACAAGTAAAGTCTGTTT
AAAGTGTCATGATGAATGTGCTAAAACGTGTTCCGGGTTGAGATCTGATC
AATGTATTGGAGGTTGTAAGCATGCTATGGAAAACTCGATGTGTGTTCGT
GAATGCTCGAGAACTCACTTTTTAAACAAAATCACTAAAACATGTGAACC
GTGTCATAAGGATTGTCACTCTAGAAGTATTACTCGACTACCAGTCTGTA
CAGGTCCTTCAAATACTCCTGGACCTGGAGGTTGCAACAAATGTCAATCA
ATGATATTAAGGAGAGATTATCAAGTAGAAAGATGTTACCAAAATACATC
TCTGAATGGTTATTTCAGCCTAAATCATCCAAATACAAACAGTTCTCCCC
ATTCTAATTTCATTGAAAAGTTTACAGATCTCATAGTAATACTGGAACCT
TGTCATGATTTATGCAGTCAATGTACAATCAGAACAGATCAAAGAATCTC
TTTATCAAAGACTGATTGGAAAGGATGTACTCAATGTAAAGGATATTGGT
TTGATGATAAATGTGTATCAATATGTCCAAAAGTGAGAACCTTTCTCAAA
GCCGATGAAACAAATTCTAGTCTTGGAAAATGTCACCCGTGTCATCCGCA
GTGTAATGGTTGTTATGGTGTTGATAAAAATCATTGTATACATTGCAATA
ATTTTAAACTTCCTGAAAATGAAAATCTTACTTTATTTTCCTGTGTCGAA
AGTTGTCCATCGAACTACAAAGAAACTAGTGGAAATTCAAATGAAAATAT
TTGCGTTTTTGTTTTTCTCAGTGGCTTGGAATTAATTTTAGTGATTCTAG
CAGTGGTGTTCCTTTTTGTCCTTTTTACTTTATTTATTATCATTACAAAA
TTTTGCCTTGCAAGAAAAGGAAAAAGAAAAAGAGATAAACTGAAAGCATA
TTTCTCTAATGCAAATGAATCAGACAGTCAAACACCAAGTCCTCCGAACA
TGAATCACTTGTTGGTCATTTCTAGTGATAATCTGGAATTTATAATGGGT
GGAGAGATTCTTGGGAAAGGAACATTTGGTTCTGTATACGCGGGTAAATG
GAAACTTGATAATGGCTGTTTTGATGACAATAGTAGTATGAACTCTTGTA
AAGATAGCAAAGTAGACGTAGTCATTAAAGTTTTAAATCATTCTTGTGAT
CAGAATGAATTCATGGACGAAGTCAGGATTATGGCTTCTGTAAGACACAA
ACATTGTTTGCGATTGATCGGTGTATCTTATAAAGGAAGTGAAAAATTAT
TAATATCAAGTTATATGCCCCTAGGAAGTATGGAAAAATATTTGGAAAAA
AATAAAAAAAGTCTTACTGGGAAAATTCTGTTGAAATGGGCCGAACAGAT
AGCAAATGGCATGTTGTACTTAGAAAACAATCACATTATCCATCGAGATT
TGGCTACTAGAAATGTGCTCATATACAAAGAAAATCATGTGCAAATCACA
GATTTTGGTTTGTCGAAAATTATAAATCCCAATAAAGATGAAATGCAAAT
ATTTGGTGGAATGGTACCGGTGCGCTGGTTGGCCATTGAAACTTTAAGAG
ACGGGATTTATTCTCACAAAACGGACGTATGGGCATATGCTGTCACATTA
TGGGAGATATTTACCTTTGCAACTGTTCCATATGAATTTCTCAAAGCGCA
TGAGATAAGAGATGAAATTATTAAAGGAACTCGATTGCGTCAACCAGATA
TTTGCTCCCTAGACATTTATATATTAATGCTTAAATGCTGGAGCGTTGAT
CCTGAAGAACGACCGAATTTTGAATATTTATGGACGGAATTTAAGAACTA
TAGCAACAATTCAGAAACATATCTTTCATATCCTAATGTTGAACAAAATT
ATACGACCAATACGTTTAATAATTACATTGAAATAAAACAGCATGAAGAC
GAGATATCTTACCATGCCCCTCACTCTCCTAATCAAAACAGAGTCCGAGT
TATTGGTAACATGAGACCAAGAGGGAATCAAAAGAGTATAATAGTTCCTG
AGCATGTTCAAAGATTTTTAAATGGACCACCCATCAGAAATCTCTTATAC
GAACCAGTGAATTTTTCCAAAACCTCAAATATTACTCTAAATGGGTCGTT
TAATAAATCAAACGGAAATACAAATTATCATGATTTTCATTCACGTCCGG
ATGTTTCTCCGAGTTCATTGACTATAGAATATCTTGAACCACTTACAACA
AGAATTTGATTAGAAAATTTAATGATAAGCATTTATAGCATATTTGATCA
TTCTTTTGTAAATCATGTTTTCATTTTATATTATATGGTACCTCATTTTA
TTATTTACTGTACTTTTACATAACTTTAAAGTTAAGCATATGATCATAC
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protein sequence of SMED30009712-orf-1

>SMED30009712-orf-1 ID=SMED30009712-orf-1|Name=SMED30009712-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1318bp
MLYLSYCWIYLHILLISLIFYRYSDSLIEYPEIKYCFSSMDLLDGSQSSN
YNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKI
RNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIK
TVIDLRSLRSIVSGNIYISSQFCSSLANVEWNELLEDPTRQSVTGKCTPQ
PTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEEC
CNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNK
YFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCKILCEQ
ICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRP
EIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESL
VPIISTSLTIINTDISYLGLKSLKIIKNKAIFFKNNTKLCYFDIKKFKNI
VKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCIS
CANVRLGTICAENCLVQPGYLTNPDSTSKVCLKCHDECAKTCSGLRSDQC
IGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTG
PSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHS
NFIEKFTDLIVILEPCHDLCSQCTIRTDQRISLSKTDWKGCTQCKGYWFD
DKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNGCYGVDKNHCIHCNNF
KLPENENLTLFSCVESCPSNYKETSGNSNENICVFVFLSGLELILVILAV
VFLFVLFTLFIIITKFCLARKGKRKRDKLKAYFSNANESDSQTPSPPNMN
HLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKD
SKVDVVIKVLNHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLI
SSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLA
TRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDG
IYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDIC
SLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPNVEQNYT
TNTFNNYIEIKQHEDEISYHAPHSPNQNRVRVIGNMRPRGNQKSIIVPEH
VQRFLNGPPIRNLLYEPVNFSKTSNITLNGSFNKSNGNTNYHDFHSRPDV
SPSSLTIEYLEPLTTRI*
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Aliases
The feature 'epidermal growth factor receptor 1' has the following synonyms
Synonym
EGFR1
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000026gut
PLANA:0000031pigment cup cell
PLANA:0000034epidermis
PLANA:0000036eye
PLANA:0000062esophagus
PLANA:0000070intestinal phagocyte
PLANA:0000072mouth
PLANA:0000429neoblast
PLANA:0002032epidermal cell
PLANA:0002075pigment cell
PLANA:0002142parenchyma
PLANA:0003116parenchymal cell
PLANA:0004528pharynx epithelium
Vocabulary: INTERPRO
TermDefinition
IPR036941Rcpt_L-dom_sf
IPR001245Ser-Thr/Tyr_kinase_cat_dom
IPR020635Tyr_kinase_cat_dom
IPR006212Furin_repeat
IPR000494Rcpt_L-dom
IPR006211Furin-like_Cys-rich_dom
IPR032778GF_recep_IV
IPR008266Tyr_kinase_AS
IPR000719Prot_kinase_dom
IPR009030Growth_fac_rcpt_cys_sf
IPR032675LRR_dom_sf
IPR011009Kinase-like_dom_sf
IPR011528NERD
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0004713protein tyrosine kinase activity
GO:0004714transmembrane receptor protein tyrosine kinase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0016301kinase activity
GO:0016740transferase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016310phosphorylation
GO:0018108peptidyl-tyrosine phosphorylation
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPRINTSPR00109TYRKINASEcoord: 1087..1097
score: 46.17
coord: 1038..1056
score: 56.14
coord: 1001..1014
score: 28.74
coord: 1150..1172
score: 45.35
coord: 1106..1128
score: 43.31
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPFAMPF07714Pkinase_Tyrcoord: 916..1177
e-value: 1.6E-77
score: 260.3
IPR006212Furin-like repeatSMARTSM00261furin_3coord: 247..289
e-value: 9.6E-5
score: 31.8
coord: 578..623
e-value: 1.2E-5
score: 34.8
coord: 710..764
e-value: 0.6
score: 19.2
coord: 773..823
e-value: 2.5E-6
score: 37.0
coord: 520..572
e-value: 0.002
score: 27.4
coord: 627..688
e-value: 10.0
score: 10.4
IPR006212Furin-like repeatCDDcd00064FUcoord: 778..828
e-value: 1.71331E-5
score: 41.3504
IPR006212Furin-like repeatCDDcd00064FUcoord: 583..631
e-value: 0.0024287
score: 35.1872
IPR006212Furin-like repeatCDDcd00064FUcoord: 250..285
e-value: 0.00178869
score: 35.5724
IPR020635Tyrosine-protein kinase, catalytic domainSMARTSM00219tyrkin_6coord: 913..1179
e-value: 2.0E-100
score: 349.6
IPR032778Growth factor receptor domain 4PFAMPF14843GF_recep_IVcoord: 529..639
e-value: 1.8E-15
score: 56.9
coord: 739..823
e-value: 3.7E-7
score: 30.0
NoneNo IPR availableGENE3DG3DSA:2.10.220.10coord: 713..835
e-value: 1.3E-12
score: 49.5
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 863..1001
e-value: 2.8E-20
score: 74.4
NoneNo IPR availableGENE3DG3DSA:2.10.220.10coord: 228..348
e-value: 5.9E-21
score: 76.6
NoneNo IPR availableGENE3DG3DSA:2.10.220.10coord: 589..680
e-value: 1.4E-8
score: 36.7
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 1004..1205
e-value: 3.2E-52
score: 178.7
NoneNo IPR availablePANTHERPTHR24416TYROSINE-PROTEIN KINASE RECEPTORcoord: 46..534
NoneNo IPR availablePANTHERPTHR24416TYROSINE-PROTEIN KINASE RECEPTORcoord: 539..1235
NoneNo IPR availablePANTHERPTHR24416:SF95EPIDERMAL GROWTH FACTOR RECEPTORcoord: 539..1235
coord: 46..534
NoneNo IPR availableSUPERFAMILYSSF52058L domain-likecoord: 372..546
NoneNo IPR availableSUPERFAMILYSSF52058L domain-likecoord: 57..221
NoneNo IPR availableTMHMMTMhelixcoord: 844..866
NoneNo IPR availableTMHMMTMhelixcoord: 2..24
IPR036941Receptor L-domain superfamilyGENE3DG3DSA:3.80.20.20coord: 35..227
e-value: 9.5E-33
score: 115.5
IPR036941Receptor L-domain superfamilyGENE3DG3DSA:3.80.20.20coord: 362..563
e-value: 5.9E-41
score: 142.4
IPR000494Receptor L-domainPFAMPF01030Recep_L_domaincoord: 61..184
e-value: 1.6E-14
score: 54.0
coord: 380..494
e-value: 1.5E-15
score: 57.3
IPR006211Furin-like cysteine-rich domainPFAMPF00757Furin-likecoord: 197..353
e-value: 2.0E-15
score: 57.0
IPR008266Tyrosine-protein kinase, active sitePROSITEPS00109PROTEIN_KINASE_TYRcoord: 1044..1056
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 913..1190
score: 35.269
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 916..1197
IPR009030Growth factor receptor cysteine-rich domain superfamilySUPERFAMILYSSF57184Growth factor receptor domaincoord: 204..353
IPR009030Growth factor receptor cysteine-rich domain superfamilySUPERFAMILYSSF57184Growth factor receptor domaincoord: 530..638
IPR009030Growth factor receptor cysteine-rich domain superfamilySUPERFAMILYSSF57184Growth factor receptor domaincoord: 653..834