UPF0565 protein C2orf69

Overview
NameUPF0565 protein C2orf69
Smed IDSMED30009658
Length (bp)1206
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of UPF0565 protein C2orf69 (SMED30009658) t-SNE clustered cells

Violin plots show distribution of expression levels for UPF0565 protein C2orf69 (SMED30009658) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of UPF0565 protein C2orf69 (SMED30009658) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for UPF0565 protein C2orf69 (SMED30009658) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30009658

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30009658SMESG000081380.1 dd_Smed_v4_12694_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30009658SMESG000081380.1 dd_Smed_v4_12694_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Human
Match: C2orf69 (chromosome 2 open reading frame 69 [Source:HGNC Symbol;Acc:HGNC:26799])

HSP 1 Score: 87.4261 bits (215), Expect = 2.223e-18
Identity = 82/294 (27.89%), Postives = 125/294 (42.52%), Query Frame = 2 
Query:  380 PNLNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKML---LEDKSLTVFPKIDI-------PLH----------------------------------LIGFSKGCTVLTQLLYDLSQVQ-DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            P  +V+Y  GD+Q+ +E M        ++ +SLE+ A+ L  R+       +I+ I+        F+ Y+NFV     G P +  D   GA      L+ +   +    L  KSL V+ K  I       P H                                  LIGFSKGC VL QLL++L + + D  I     +I  MYWLD GH+G +  W T   +L  F +     +H   TP+Q+    R     E++KF +IL  +  +        +E  ++E HF+V +VF
Sbjct:   99 PQHHVLYFPGDVQNYHEIMTRHPENYQWENWSLENVATILAHRFPN----SYIWVIKCSRMHLHKFSCYDNFVKSNMFGAPEHNTD--FGAFKHLYMLLVNAFNLSQNSLSKKSLNVWNKDSIASNCRSSPSHTTNGCQGEKVRTCEKSDESAMSFYPPSLNDASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKSIRTMYWLDGGHSGGSNTWVTYPEVLKEFAQT-GIIVHTHVTPYQVRDPMRSWIGKEHKKFVQILGDLGMQVTSQIHFTKEAPSIENHFRVHEVF 385
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Fly
Match: CG31122 (gene:FBgn0051122 transcript:FBtr0333831)

HSP 1 Score: 78.5666 bits (192), Expect = 1.675e-15
Identity = 46/133 (34.59%), Postives = 65/133 (48.87%), Query Frame = 2 
Query:  725 LHLIGFSKGCTVLTQLLYDLSQVQ-----DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            L LIGFSKGC VL Q +Y+   ++     D  + +L + I DMYWLD GH G    W TS ++L    +     IH   TP+Q+    R     E + F ++LR +N           +   L THF+V+  F
Sbjct:  345 LVLIGFSKGCVVLNQFIYEFHYLKTLTPDDSSMCRLLSRISDMYWLDGGHGGQKNTWITSRSLLETLTRMAGMNIHVHLTPYQVQDDRRPWIRKEEKLFTEMLRRLNAPITRHLHYDNQPANLMTHFEVLQAF 477
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Fly
Match: CG31122 (gene:FBgn0051122 transcript:FBtr0301432)

HSP 1 Score: 75.8702 bits (185), Expect = 1.328e-14
Identity = 47/133 (35.34%), Postives = 65/133 (48.87%), Query Frame = 2 
Query:  725 LHLIGFSKGCTVLTQLLYDLSQVQ-----DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            L LIGFSKGC VL Q +Y+   ++     D  + +L + I DMYWLD GH G    W TS ++L   L      IH   TP+Q+    R     E + F ++LR +N           +   L THF+V+  F
Sbjct:  345 LVLIGFSKGCVVLNQFIYEFHYLKTLTPDDSSMCRLLSRISDMYWLDGGHGGQKNTWITSRSLLET-LTRMGMNIHVHLTPYQVQDDRRPWIRKEEKLFTEMLRRLNAPITRHLHYDNQPANLMTHFEVLQAF 476
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Fly
Match: CG31122 (gene:FBgn0051122 transcript:FBtr0474142)

HSP 1 Score: 75.8702 bits (185), Expect = 1.525e-14
Identity = 46/131 (35.11%), Postives = 64/131 (48.85%), Query Frame = 2 
Query:  731 LIGFSKGCTVLTQLLYDLSQVQ-----DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            LIGFSKGC VL Q +Y+   ++     D  + +L + I DMYWLD GH G    W TS ++L   L      IH   TP+Q+    R     E + F ++LR +N           +   L THF+V+  F
Sbjct:  347 LIGFSKGCVVLNQFIYEFHYLKTLTPDDSSMCRLLSRISDMYWLDGGHGGQKNTWITSRSLLET-LTRMGMNIHVHLTPYQVQDDRRPWIRKEEKLFTEMLRRLNAPITRHLHYDNQPANLMTHFEVLQAF 476
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Zebrafish
Match: zgc:153521 (zgc:153521 [Source:NCBI gene;Acc:777620])

HSP 1 Score: 97.4413 bits (241), Expect = 3.188e-22
Identity = 70/257 (27.24%), Postives = 116/257 (45.14%), Query Frame = 2 
Query:  383 NLNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVFPKIDIP--------LHLIGFSKGCTVLTQLLYDLSQVQDFKIYKLFTN-ILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            N +V++  GDIQ+  + M +      ++ +SLES    L  R+    C  HI+ IR        F+ Y NFV+    G P +  D   GA    ++L+   ++       L        P        L ++ FSKGC VL Q++Y+L+  +     +LF + +  +YWLD GH G +E W T +  L   L +    +H   TP+++    R     E+  F K L  +  +       ++E  +++ HF+VI  F
Sbjct:   92 NDHVVFFPGDIQNFQQEMALQPDAAPWQCWSLESVGLTLAHRFP--GC--HIWVIRASQMYLHKFSCYQNFVESNLFGAPEHSAD--YGAIRHLRALLGHSMQQAGLPNPLPPLSGTSTPGPLPAGFSLTIVAFSKGCVVLNQIVYELAGARADPELQLFLDRVSALYWLDGGHPGGSETWVTDKCALGE-LASSGVAVHAHVTPYEVRDPMRAWVGREHRHFIKTLEDLGARVSHKLHFEDEPASIDNHFRVIQEF 341
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Zebrafish
Match: C9H2orf69 (zgc:153521 [Source:NCBI gene;Acc:777620])

HSP 1 Score: 97.4413 bits (241), Expect = 3.814e-22
Identity = 70/257 (27.24%), Postives = 116/257 (45.14%), Query Frame = 2 
Query:  383 NLNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVFPKIDIP--------LHLIGFSKGCTVLTQLLYDLSQVQDFKIYKLFTN-ILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            N +V++  GDIQ+  + M +      ++ +SLES    L  R+    C  HI+ IR        F+ Y NFV+    G P +  D   GA    ++L+   ++       L        P        L ++ FSKGC VL Q++Y+L+  +     +LF + +  +YWLD GH G +E W T +  L   L +    +H   TP+++    R     E+  F K L  +  +       ++E  +++ HF+VI  F
Sbjct:   96 NDHVVFFPGDIQNFQQEMALQPDAAPWQCWSLESVGLTLAHRFP--GC--HIWVIRASQMYLHKFSCYQNFVESNLFGAPEHSAD--YGAIRHLRALLGHSMQQAGLPNPLPPLSGTSTPGPLPAGFSLTIVAFSKGCVVLNQIVYELAGARADPELQLFLDRVSALYWLDGGHPGGSETWVTDKCALGE-LASSGVAVHAHVTPYEVRDPMRAWVGREHRHFIKTLEDLGARVSHKLHFEDEPASIDNHFRVIQEF 345
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Xenopus
Match: C2orf69 (chromosome 2 open reading frame 69 [Source:NCBI gene;Acc:549281])

HSP 1 Score: 102.449 bits (254), Expect = 1.051e-23
Identity = 90/305 (29.51%), Postives = 134/305 (43.93%), Query Frame = 2 
Query:  344 CNDIVFVGGKGNPN--LNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLIT---SCVKMLL----------EDKSLTVF-----------PKIDIPLH-----------------LIGFSKGCTVLTQLLYDLSQ-VQDFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            CND+V    + +     +V+Y  GD+Q+  + M        +K +SLE  A  L +R+       +I+ I+        F+ Y+NFV+    G P  K     GA    QSL+T   S  + LL           D  L+             P+ D  +H                 +IGFSKGC VL QLLY+L + ++D  I     NI  MYWLD GH+G  + W T+  IL  F       +H   TP+Q+  + R     E+ KF ++L+  N K +       E  +L+ HF+V +VF
Sbjct:   50 CNDVVLRPARESSQKPQHVVYFPGDVQNYRDVMASHPENFRWKQWSLEDVADMLSQRFPY----SYIWIIKSSRMHLHKFSCYDNFVESNMFGAP--KHSTELGAFKHLQSLLTNAFSAAQSLLVSQNNKYSVDRDYDLSKMDICPTYTTNGCPEKDNIIHSTIYLGMPSLKDSLSITVIGFSKGCVVLNQLLYELQEAIKDKDIQSFLANIKAMYWLDGGHSGGCDTWITNPEILKAFALT-GIAVHTHVTPYQVRDIMRSWIGEEHRKFVQLLKKYNVKVENQLHFSYEMPSLDNHFQVHEVF 347
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Mouse
Match: 1700066M21Rik (RIKEN cDNA 1700066M21 gene [Source:MGI Symbol;Acc:MGI:1920717])

HSP 1 Score: 87.0409 bits (214), Expect = 2.039e-18
Identity = 78/290 (26.90%), Postives = 125/290 (43.10%), Query Frame = 2 
Query:  389 NVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVK-----MLLEDKSL-----------------------------------TVFPKIDI---PLHLIGFSKGCTVLTQLLYDLSQVQ-DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            +V+Y  GD+Q+ +E M        ++ +SLE+ A+ L  R+       +I+ I+        F+ Y+NFV     G P  +  P  GA      L+ +        ML +++S+                                     FP + +      LIGFSKGC VL QLL++L + + D  I     +I  MYWLD GH+G +  W T   +L  F +     +H   TP+Q+    R     E++KF +ILR +  +        +E  ++E HF+V +VF
Sbjct:   83 HVLYFPGDVQNYHEIMTRHPENYQWENWSLENIATILARRFPN----SYIWVIKCSRMHLHKFSCYDNFVKSNMFGAP--EHTPDFGAFKHLYMLLVNAFNLTQNGMLFKNRSVWNKDCKASNCESNPSTSNGGQKENERTCEHVDEPSMSFPPLSLDGASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKSIRTMYWLDGGHSGGSNTWVTYPEVLEEFAQT-GITVHTHVTPYQVHDPMRSWIGKEHKKFVQILRDLGMQVTSQIHFAKETPSIENHFRVHEVF 365
[Close]
BLAST of UPF0565 protein C2orf69 vs. UniProt/SwissProt
Match: sp|A0JMH2|CB069_DANRE (UPF0565 protein C2orf69 homolog OS=Danio rerio OX=7955 GN=zgc:153521 PE=2 SV=1)

HSP 1 Score: 97.8265 bits (242), Expect = 1.851e-21
Identity = 70/257 (27.24%), Postives = 116/257 (45.14%), Query Frame = 2 
Query:  383 NLNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVFPKIDIP--------LHLIGFSKGCTVLTQLLYDLSQVQDFKIYKLFTN-ILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            N +V++  GDIQ+  + M +      ++ +SLE     L  R+    C  HI+ IR        F+ Y NFV+    G P +  D   GA    ++L+   ++       L        P        L ++GFSKGC VL Q++Y+L+  +     +LF + +  +YWLD GH G +E W T +  L   L +    +H   TP+++    R     E+  F K L  +  +       ++E  +++ HF+VI  F
Sbjct:   92 NDHVVFFPGDIQNFQQEMALQPDAAPWQCWSLERVGLTLAHRFP--GC--HIWVIRASQMYLHKFSCYQNFVESNLFGAPEHSAD--YGAIRHLRALLGHSMQQAGLPNPLPPLSGTSTPGPLPAGFSLTIVGFSKGCVVLNQIVYELAGARADPELQLFLDRVSALYWLDGGHPGGSETWVTDKCALGE-LASSGVAVHAHVTPYEVRDPMRAWVGREHRHFIKTLEDLGARVSHKLHFEDEPASIDNHFRVIQEF 341
[Close]
BLAST of UPF0565 protein C2orf69 vs. UniProt/SwissProt
Match: sp|Q8N8R5|CB069_HUMAN (UPF0565 protein C2orf69 OS=Homo sapiens OX=9606 GN=C2orf69 PE=1 SV=1)

HSP 1 Score: 87.4261 bits (215), Expect = 1.068e-17
Identity = 82/294 (27.89%), Postives = 125/294 (42.52%), Query Frame = 2 
Query:  380 PNLNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKML---LEDKSLTVFPKIDI-------PLH----------------------------------LIGFSKGCTVLTQLLYDLSQVQ-DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            P  +V+Y  GD+Q+ +E M        ++ +SLE+ A+ L  R+       +I+ I+        F+ Y+NFV     G P +  D   GA      L+ +   +    L  KSL V+ K  I       P H                                  LIGFSKGC VL QLL++L + + D  I     +I  MYWLD GH+G +  W T   +L  F +     +H   TP+Q+    R     E++KF +IL  +  +        +E  ++E HF+V +VF
Sbjct:   99 PQHHVLYFPGDVQNYHEIMTRHPENYQWENWSLENVATILAHRFPN----SYIWVIKCSRMHLHKFSCYDNFVKSNMFGAPEHNTD--FGAFKHLYMLLVNAFNLSQNSLSKKSLNVWNKDSIASNCRSSPSHTTNGCQGEKVRTCEKSDESAMSFYPPSLNDASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKSIRTMYWLDGGHSGGSNTWVTYPEVLKEFAQT-GIIVHTHVTPYQVRDPMRSWIGKEHKKFVQILGDLGMQVTSQIHFTKEAPSIENHFRVHEVF 385
[Close]
BLAST of UPF0565 protein C2orf69 vs. UniProt/SwissProt
Match: sp|Q9D9H8|CB069_MOUSE (UPF0565 protein C2orf69 homolog OS=Mus musculus OX=10090 PE=2 SV=3)

HSP 1 Score: 87.0409 bits (214), Expect = 1.426e-17
Identity = 78/290 (26.90%), Postives = 125/290 (43.10%), Query Frame = 2 
Query:  389 NVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVK-----MLLEDKSL-----------------------------------TVFPKIDI---PLHLIGFSKGCTVLTQLLYDLSQVQ-DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            +V+Y  GD+Q+ +E M        ++ +SLE+ A+ L  R+       +I+ I+        F+ Y+NFV     G P  +  P  GA      L+ +        ML +++S+                                     FP + +      LIGFSKGC VL QLL++L + + D  I     +I  MYWLD GH+G +  W T   +L  F +     +H   TP+Q+    R     E++KF +ILR +  +        +E  ++E HF+V +VF
Sbjct:   83 HVLYFPGDVQNYHEIMTRHPENYQWENWSLENIATILARRFPN----SYIWVIKCSRMHLHKFSCYDNFVKSNMFGAP--EHTPDFGAFKHLYMLLVNAFNLTQNGMLFKNRSVWNKDCKASNCESNPSTSNGGQKENERTCEHVDEPSMSFPPLSLDGASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKSIRTMYWLDGGHSGGSNTWVTYPEVLEEFAQT-GITVHTHVTPYQVHDPMRSWIGKEHKKFVQILRDLGMQVTSQIHFAKETPSIENHFRVHEVF 365
[Close]
BLAST of UPF0565 protein C2orf69 vs. TrEMBL
Match: A0A074Z3U8 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_15016 PE=4 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 7.705e-35
Identity = 94/296 (31.76%), Postives = 144/296 (48.65%), Query Frame = 2 
Query:  314 VLKNVHGIKGC-NDIVFVGGKGNPNLNVIYIGGDIQDLNENM------KIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFD-PLKGAANQFQSLITSCVKMLLEDKSLTVFPKID-IPLHLIGFSKGCTVLTQLLYDLSQVQDFKIY------------KLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNT----------LETHFKVIDVF 1108
            +L N  G  G  ND++F+G  G  + NV+YIGGDIQD   NM      + +  +SLE+T   L ERY      +H++ IRP  + +  FA Y NFV +   GNPI     P K    +  S +     M L+++   +  + +  P+ +IGFSKGC +LT LLY LS  + + +             +  +NI  +YWLD+GH+G    WPTSE  LS   ++    +H + TP+Q+    R     +Y  F  +L      ++   L K+E             ++THF ++  F
Sbjct:   10 LLLNCTGYGGLRNDVLFIGRPGPASSNVVYIGGDIQDTECNMQNQPAKRAFINWSLEATGRLLVERYALQGRNIHLWMIRPCQWVSNVFASYRNFVSVDPNGNPILSDSIPTKSDLVEHLSGLVEDAAMKLQNQQPEIASRFEGTPVTVIGFSKGCCILTGLLYILSACKPYTLRESGLLVPSDGAKRFLSNIRALYWLDAGHSGVEHQWPTSEANLSVLRRSACPELHVYATPYQVEDKLRPWKAHDYHTFIGLLAKYALPHKHAVLFKDEQTKRKEQLPDTADIQTHFSILKHF 305

HSP 2 Score: 58.9214 bits (141), Expect = 6.906e-6
Identity = 33/81 (40.74%), Postives = 46/81 (56.79%), Query Frame = -2 
Query:   27 VLKNVHGIKGC-NDIVFVGGKGNPNLNVIYIGGDIQDLNENM------KIYKVYSLESTASKLFERYKKHNCPVHIYAIRP 248
            +L N  G  G  ND++F+G  G  + NV+YIGGDIQD   NM      + +  +SLE+T   L ERY      +H++ IRP
Sbjct:   10 LLLNCTGYGGLRNDVLFIGRPGPASSNVVYIGGDIQDTECNMQNQPAKRAFINWSLEATGRLLVERYALQGRNIHLWMIRP 90
[Close]
BLAST of UPF0565 protein C2orf69 vs. TrEMBL
Match: A0A4S2JPT5 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_011316 PE=4 SV=1)

HSP 1 Score: 140.198 bits (352), Expect = 1.269e-34
Identity = 96/302 (31.79%), Postives = 148/302 (49.01%), Query Frame = 2 
Query:  314 VLKNVHGIKGC-NDIVFVGGKGNPNLNVIYIGGDIQDLNENM------KIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVF---PKI-----DIPLHLIGFSKGCTVLTQLLYDLSQVQDFKIY------------KLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNT----------LETHFKVIDVF 1108
            +L N  G  G  ND++F+G  G  + NV+YIGGD+QD   NM      + +  +SLE+T   L ERY      +H++ IRP  + +  FA Y NFV +   GNPI   D +   ++  + L +     L+ED ++ +    P+I       P+ +IGFSKGC VLT LLY LS  + + +             +  +NI  +YWLD+GH+     WPTSE+ LS   +N    +H + TP+Q+    R     +Y  F  +L      ++   L K+E             ++THF ++  F
Sbjct:   10 LLLNCTGYGGLRNDVLFIGRPGPASSNVVYIGGDVQDTECNMQSHPEKRAFIKWSLEATGRLLVERYALQGRNIHLWMIRPCQWVSTVFASYRNFVSVDPNGNPILS-DSIPTKSDLVEHLSS-----LVEDAAIKLHNQQPEIASGFEGTPVTVIGFSKGCCVLTGLLYILSACKPYTLRESGLLLPSDGAKRFLSNIRALYWLDAGHSAVEHQWPTSESNLSVLRRNACPELHVYATPYQVEDKLRPWKAHDYHTFIGLLAKYALPHKHAVLFKDEQTKRKEQLPDTADIQTHFTILKHF 305

HSP 2 Score: 59.3066 bits (142), Expect = 4.186e-6
Identity = 33/89 (37.08%), Postives = 49/89 (55.06%), Query Frame = -2 
Query:    3 VLKNVHGIKGC-NDIVFVGGKGNPNLNVIYIGGDIQDLNENM------KIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTF 248
            +L N  G  G  ND++F+G  G  + NV+YIGGD+QD   NM      + +  +SLE+T   L ERY      +H++ IRP  + +  F
Sbjct:   10 LLLNCTGYGGLRNDVLFIGRPGPASSNVVYIGGDVQDTECNMQSHPEKRAFIKWSLEATGRLLVERYALQGRNIHLWMIRPCQWVSTVF 98
[Close]
BLAST of UPF0565 protein C2orf69 vs. TrEMBL
Match: H2KRB5 (UPF0565 protein C2orf69 homolog OS=Clonorchis sinensis OX=79923 GN=CLF_105911 PE=4 SV=1)

HSP 1 Score: 140.198 bits (352), Expect = 1.678e-34
Identity = 101/304 (33.22%), Postives = 147/304 (48.36%), Query Frame = 2 
Query:  314 VLKNVHGIKGC-NDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYK------VYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVF---PKI-----DIPLHLIGFSKGCTVLTQLLYDLSQVQDFKIY------------KLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNT----------LETHFKVIDVFPL 1114
            +L N  G  G  ND++F G  G  + NV+YIGGDIQD   NM+ +        +SLE+T   L ERY      VH++ IRP  + +  FA Y NFV +   GNPI   D +   ++  + L +     L+ED ++ V    P+I      IP+ +IGFSKGC VLT LLY LS  + + +             +  +NI  +YWLD+GH+     WPTSE  LS   +     +H + TP+Q+    R     +Y  F  +L      ++   L K+E             ++THF V+  F L
Sbjct:   25 LLLNCTGYGGLRNDVLFFGRPGPASSNVVYIGGDIQDTECNMQSHPEKRGFVKWSLEATGRLLVERYALQGRNVHLWMIRPCQWVSNVFASYRNFVSVDPNGNPILS-DSIPTNSDLVEHLSS-----LIEDAAMKVRKHKPEIATGFEGIPVTVIGFSKGCCVLTGLLYILSACKPYTLRESGLLVPSDGAKRFLSNIRALYWLDAGHSAVEHQWPTSEANLSVLRRTACPELHAYATPYQVEDKLRPWKARDYHTFIGLLAKYALPHKHAVLFKDEQTKRKEQLPDTADIQTHFTVLKHFLL 322
[Close]
BLAST of UPF0565 protein C2orf69 vs. TrEMBL
Match: Q5BYR9 (SJCHGC02440 protein (Fragment) OS=Schistosoma japonicum OX=6182 PE=2 SV=2)

HSP 1 Score: 137.502 bits (345), Expect = 4.856e-34
Identity = 91/266 (34.21%), Postives = 139/266 (52.26%), Query Frame = 2 
Query:  329 HGIKGC-------NDIVFVGGKGNPNLNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKH--NCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLK--GAANQFQSLITSCVKMLLE-DKSLTVFPKIDIPLHLIGFSKGCTVLTQLLYDLS-----------QVQDF--KIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCR-IHGFGTPFQLCRLNRERSFVEYEKFEKILRVIN 1030
            H +K C       ND++F+G +  P +N++Y GGDIQD   NM        Y  ++LE+TA  L+ER+     NC  HI+ IR   +   + A YNNF+   + G P+Y+ + +           ++++ V+ LL  DK +      DIP+ L+GFSKGC VLT+L+Y+ S           +V++   +I +   N+ D+YWLDSGH+G    WP   N LS  L   +C  IH   +P+QL    R +   ++ KF  IL  +N
Sbjct:    6 HELKNCVGYLNKRNDVIFLGTRSCPYVNLVYFGGDIQDYEYNMHQNNFSNQYIKWNLENTAQNLYERFTNQFPNCHPHIWIIRASHWLPSSIACYNNFLHFTKSGVPLYENEEISKITGMQHLSYVLSNAVEQLLNFDKDIQC-QITDIPMRLVGFSKGCCVLTELIYEFSVLCHSEKVPNNRVKEISTQIMEFCRNLTDIYWLDSGHSGTYHHWPVLVNYLS-LLNPGSCPVIHVHASPYQLANPLRPQKSTDFHKFLDILSNLN 269
[Close]
BLAST of UPF0565 protein C2orf69 vs. TrEMBL
Match: A0A3R7F2Z0 (UPF0565 protein C2orf69-like protein OS=Clonorchis sinensis OX=79923 GN=CSKR_13114s PE=4 SV=1)

HSP 1 Score: 138.658 bits (348), Expect = 4.978e-34
Identity = 101/304 (33.22%), Postives = 146/304 (48.03%), Query Frame = 2 
Query:  314 VLKNVHGIKGC-NDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYK------VYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVF---PKI-----DIPLHLIGFSKGCTVLTQLLYDLSQVQDFKIY------------KLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNT----------LETHFKVIDVFPL 1114
            +L N  G  G  ND++F G  G  + NV+YIGGDIQD   NM+ +        +SLE+T   L ERY      VH++ IRP  + +  FA Y NFV +   GNPI   D +   ++  + L +     L+ED +  V    P+I      IP+ +IGFSKGC VLT LLY LS  + + +             +  +NI  +YWLD+GH+     WPTSE  LS   +     +H + TP+Q+    R     +Y  F  +L      ++   L K+E             ++THF V+  F L
Sbjct:   25 LLLNCTGYGGLRNDVLFFGRPGPASSNVVYIGGDIQDTECNMQSHPEKRGFVKWSLEATGRLLVERYALQGRNVHLWMIRPCQWVSNVFASYRNFVSVDPNGNPILS-DSIPTNSDLVEHLSS-----LIEDAATKVRKHKPEIATGFEGIPVTVIGFSKGCCVLTGLLYILSACKPYTLRESGLLVPSDGAKRFLSNIRALYWLDAGHSAVEHQWPTSEANLSVLRRTACPELHAYATPYQVEDKLRPWKARDYHTFIGLLAKYALPHKHAVLFKDEQTKRKEQLPDTADIQTHFTVLKHFLL 322
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Cavefish
Match: zgc:153521 (chromosome unknown C2orf69 homolog [Source:NCBI gene;Acc:103027771])

HSP 1 Score: 105.531 bits (262), Expect = 4.070e-25
Identity = 76/268 (28.36%), Postives = 123/268 (45.90%), Query Frame = 2 
Query:  347 NDIVFVGGKG--NPNLNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKML-----LEDKSLTVFPKIDIPLHLIGFSKGCTVLTQLLYDLSQVQ-DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            ND++ +  +G  +   +V++  GDIQ+  + M +      ++ +SLE  A  L  R+    C  HI+ IR        F+ Y NFV+    G P  +  P  GA    + L+   ++       L       F      L L+GFSKGC VL Q++Y+L+  + D ++    ++I DMYWLD GH G +E W T +  L   L      +H   TP+++    R     E+ +F K L  +          + E  +++ HF+VI  F
Sbjct:   71 NDLLLLSPEGPRSETGHVVFFPGDIQNFQQEMALQPDAAPWQCWSLERVAVMLGARFP--GC--HIWVIRASRMYLHKFSCYQNFVESNLFGAP--EHSPDYGALRHLRGLLGHGMERAGLPNPLPPLGGAAFLPHGFALTLVGFSKGCVVLNQMVYELAGAKTDLELQPFLSSISDMYWLDGGHPGGSETWVTDKRALGE-LATCGVTVHAHVTPYEVRDPMRAWVGREHRRFIKALEELGACVTHRLHFENEPASIDNHFRVIKEF 331
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Sea Lamprey
Match: zgc:153521 (chromosome 2 open reading frame 69 [Source:HGNC Symbol;Acc:HGNC:26799])

HSP 1 Score: 97.8265 bits (242), Expect = 3.023e-23
Identity = 86/329 (26.14%), Postives = 136/329 (41.34%), Query Frame = 2 
Query:  275 CKSSHSKF*MKIKVLKNVHGIKGCNDIVFVG---GKGNPNLNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLL----------EDKSLTVFPKIDIP------------------------------LHLIGFSKGCTVLTQLLYDLSQVQ-DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNF-LKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            C S  ++  + +  L  V G+  C + V V       +P  +V+Y  GDIQ   + M        ++ +SLE TA  L  R+    C   + A R  ++K   F+ Y+NFV     G P +     + A +    L+++    LL          +  S    P    P                              + L+GFSKGC VL QLLY+L+  Q D  +  +   + DMYWLD GH+G  + W T  + L        + R+H   TP+Q+C   R     E  KF  +L+            ++E ++LE HF++++ F
Sbjct:    3 CGSGEAR--VALLRLVGVAGVGACTNDVLVACPVTAESPLRHVVYFPGDIQGYRDEMAASPDSARWQRWSLEETACLLARRFPG-RCVWLVRASRMHLHK---FSCYDNFVPSNMFGAPEHASG--RTAFSHLHRLLSNARAELLGATRDGSEAGDWHSTASGPSGAPPTTDGSRDETSGPVVGEDARSAPELSNRPRTVTLVGFSKGCVVLNQLLYELAAAQGDATLAPVVGAVRDMYWLDGGHSGGRDTWVTCSDALRQLHTAGVDVRVH--VTPYQVCDPMRAWIGKEQRKFISVLQEFGATVTEQIHFEKEASSLENHFRILENF 321
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Nematostella
Match: EDO37583 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF99])

HSP 1 Score: 85.8853 bits (211), Expect = 2.679e-19
Identity = 69/248 (27.82%), Postives = 110/248 (44.35%), Query Frame = 2 
Query:  437 KIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKM--------------------LLEDKSLTVFPKIDIPLHLIGFSKGCTVLTQLLYDLSQVQ---DFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNF-NCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVF 1108
            K ++ + LESTA  L  R+        ++ IRP  Y   TF+ YNNF +    G P ++ +   GA    ++LI   + M                     L+          D P+ L+GFSKGC VL Q+ ++L+ +    D  +    + I  MYWLD GH+G A  W T E  L +   +  + R+H   TP+Q+    R     E   F + LR +    +     +++  +L  HFK+++ F
Sbjct:    3 KNWRQWDLESTARLLARRFAN----SFVWVIRPSRYHKDTFSCYNNFTEGDMFGVPDHR-NTEYGALRHLKALIIMIMNMCNANPLSGKLNYRIRSNEARFLDIADGEEDATHDFPIILVGFSKGCVVLNQITHELTGMTAGVDSSLNDFVSRISTMYWLDGGHSGEANTWVTDEKYLYHLANHIPSIRVH--VTPYQVNDWTRPWIGKEQRLFVEKLRSLGANIKVKTHFQDKEPSLFYHFKLLENF 243
[Close]
BLAST of UPF0565 protein C2orf69 vs. Ensembl Medaka
Match: zgc:153521 (chromosome 2 open reading frame 69 [Source:HGNC Symbol;Acc:HGNC:26799])

HSP 1 Score: 108.612 bits (270), Expect = 2.672e-26
Identity = 87/292 (29.79%), Postives = 139/292 (47.60%), Query Frame = 2 
Query:  311 KVLKNVHGIKGC-----NDIVFV---------GGKGNPNLNVIYIGGDIQDLNENMKI------YKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYK-FDPLKGAANQFQSLITSCVKMLLEDKSLTVFPKID-IP----LHLIGFSKGCTVLTQLLYDL-SQVQDFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVIN--PKNQCGFLLKEENNTLETHFKVI 1099
            K L+ + G+ GC     ND++ +          GK   N +V++  GDIQ+  E M        +  +SLE  A  L  R+       HI+ +R        F+ Y+NFV+    G P +  +    GA +  ++L+++ +K +     L      D IP    L L+GFSKGC VL Q++Y+L   + D ++     +I DMYWLD GH G ++ W T + +L   L      IH   TP+++C   R     E+ +F K L      P N+  F  +++  ++E HF+VI
Sbjct:   34 KKLQRLRGVPGCDPSRVNDLLLLQPDTDCSDSSGKSG-NKHVVFFHGDIQNFEEEMAQQPEGAQWLSWSLEQVALILSRRFPDS----HIWVVRASRMYLHKFSCYSNFVESNMFGAPEHSPYAADIGAFSHLRALLSNGMKRVKLPNPLQPAKGADSIPAGFSLVLVGFSKGCVVLNQMVYELPGALLDPRMSAFIKHISDMYWLDGGHPGGSKTWVTDKQVLKE-LAASGVSIHAHVTPYEVCDPMRAWMGREHRQFIKTLEEFGACPSNKLHF--EDDPPSIENHFRVI 317
[Close]
BLAST of UPF0565 protein C2orf69 vs. Planmine SMEST
Match: SMESG000081380.1 (SMESG000081380.1)

HSP 1 Score: 567 bits (1460), Expect = 0.000e+0
Identity = 276/278 (99.28%), Postives = 278/278 (100.00%), Query Frame = 2 
Query:  302 MKIKVLKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVFPKIDIPLHLIGFSKGCTVLTQLLYDLSQVQDFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVFPLILDGIEL 1135
            MKIK+LKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVFPKIDIPLHLIGFSKGCTVLTQL+YDLSQVQDFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVFPLILDGIEL
Sbjct:    1 MKIKILKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVFPKIDIPLHLIGFSKGCTVLTQLIYDLSQVQDFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVFPLILDGIEL 278

HSP 2 Score: 176.407 bits (446), Expect = 2.681e-52
Identity = 85/86 (98.84%), Postives = 86/86 (100.00%), Query Frame = -2 
Query:    3 MKIKVLKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTF 260
            MKIK+LKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTF
Sbjct:    1 MKIKILKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTF 86
[Close]
BLAST of UPF0565 protein C2orf69 vs. Planmine SMEST
Match: SMESG000081380.1 (SMESG000081380.1)

HSP 1 Score: 271.166 bits (692), Expect = 2.712e-91
Identity = 132/133 (99.25%), Postives = 133/133 (100.00%), Query Frame = 2 
Query:  302 MKIKVLKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLT 700
            MKIK+LKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLT
Sbjct:    1 MKIKILKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLT 133

HSP 2 Score: 176.022 bits (445), Expect = 3.788e-54
Identity = 85/86 (98.84%), Postives = 86/86 (100.00%), Query Frame = -2 
Query:    3 MKIKVLKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTF 260
            MKIK+LKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTF
Sbjct:    1 MKIKILKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTF 86
[Close]
BLAST of UPF0565 protein C2orf69 vs. Planmine SMEST
Match: SMESG000019402.1 (SMESG000019402.1)

HSP 1 Score: 134.806 bits (338), Expect = 4.458e-36
Identity = 91/291 (31.27%), Postives = 148/291 (50.86%), Query Frame = 2 
Query:  317 LKNVHGIKG-CNDIVFVGGKGNPNLNVIYIGGDIQDLNENM-------KIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGNPIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVFPKI----------DIPLHLIGFSKGCTVLTQLLYDL-SQVQDFKIYKLFTNILDMYWLDSGHNGNAELWPTSENILSNFLKNFNCRI------HGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGFLLKEENNTLETHFKVIDVFPL 1114
            L +V G  G  NDI+F G      LNV+Y GGDIQ+  E M       K    ++LE+    L +R+   + PVH++  RP  Y +  F +YN F+ M  +G P +  + +      F   +   ++ LL + S     K+           +P  +IGFSKG  +LT+LL ++ S++    I    T + +MYWLD+ HNG  + WP  + ++ N + +  CR+      H + TPFQ+ R  + +S  E+ +  +IL  +  +N  G+LL+ +   L+THF +I  FP+
Sbjct:   35 LYSVEGNAGKVNDILFTGFPEAARLNVLYFGGDIQNFTEFMCTDRDCNKFKDEFNLEAIGELLMKRFNDIHYPVHVWVFRPCKYIDSKFVVYNGFLKMNNDGVPSFGTNCMSQDFETFT--VIPHIRNLLNNSSQLENEKLGPLYGNICNPTLPCSVIGFSKGSVILTKLLIEINSELTCNCISPFVTLVREMYWLDASHNGEEDFWP-HDYVMFNRIAS--CRMLKGLSFHAYATPFQIGRPIKLKSCQEFSQLTEILLKLGVQNSSGYLLRGDEINLQTHFDIIKAFPI 320

HSP 2 Score: 50.8322 bits (120), Expect = 8.260e-7
Identity = 32/89 (35.96%), Postives = 45/89 (50.56%), Query Frame = -2 
Query:    3 LKNVHGIKG-CNDIVFVGGKGNPNLNVIYIGGDIQDLNENM-------KIYKVYSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTF 245
            L +V G  G  NDI+F G      LNV+Y GGDIQ+  E M       K    ++LE+    L +R+   + PVH++  RP  Y +  F
Sbjct:   35 LYSVEGNAGKVNDILFTGFPEAARLNVLYFGGDIQNFTEFMCTDRDCNKFKDEFNLEAIGELLMKRFNDIHYPVHVWVFRPCKYIDSKF 123
The following BLAST results are available for this feature:
BLAST of UPF0565 protein C2orf69 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
C2orf692.223e-1827.89chromosome 2 open reading frame 69 [Source:HGNC Sy... [more]
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CG311221.675e-1534.59gene:FBgn0051122 transcript:FBtr0333831[more]
CG311221.328e-1435.34gene:FBgn0051122 transcript:FBtr0301432[more]
CG311221.525e-1435.11gene:FBgn0051122 transcript:FBtr0474142[more]
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
zgc:1535213.188e-2227.24zgc:153521 [Source:NCBI gene;Acc:777620][more]
C9H2orf693.814e-2227.24zgc:153521 [Source:NCBI gene;Acc:777620][more]
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
C2orf691.051e-2329.51chromosome 2 open reading frame 69 [Source:NCBI ge... [more]
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
1700066M21Rik2.039e-1826.90RIKEN cDNA 1700066M21 gene [Source:MGI Symbol;Acc:... [more]
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BLAST of UPF0565 protein C2orf69 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|A0JMH2|CB069_DANRE1.851e-2127.24UPF0565 protein C2orf69 homolog OS=Danio rerio OX=... [more]
sp|Q8N8R5|CB069_HUMAN1.068e-1727.89UPF0565 protein C2orf69 OS=Homo sapiens OX=9606 GN... [more]
sp|Q9D9H8|CB069_MOUSE1.426e-1726.90UPF0565 protein C2orf69 homolog OS=Mus musculus OX... [more]
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BLAST of UPF0565 protein C2orf69 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A074Z3U87.705e-3531.76Uncharacterized protein OS=Opisthorchis viverrini ... [more]
A0A4S2JPT51.269e-3431.79Uncharacterized protein OS=Opisthorchis felineus O... [more]
H2KRB51.678e-3433.22UPF0565 protein C2orf69 homolog OS=Clonorchis sine... [more]
Q5BYR94.856e-3434.21SJCHGC02440 protein (Fragment) OS=Schistosoma japo... [more]
A0A3R7F2Z04.978e-3433.22UPF0565 protein C2orf69-like protein OS=Clonorchis... [more]
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
zgc:1535214.070e-2528.36chromosome unknown C2orf69 homolog [Source:NCBI ge... [more]
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
zgc:1535213.023e-2326.14chromosome 2 open reading frame 69 [Source:HGNC Sy... [more]
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO375832.679e-1927.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of UPF0565 protein C2orf69 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
zgc:1535212.672e-2629.79chromosome 2 open reading frame 69 [Source:HGNC Sy... [more]
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BLAST of UPF0565 protein C2orf69 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000081380.12.681e-5299.28SMESG000081380.1[more]
SMESG000081380.12.712e-9199.25SMESG000081380.1[more]
SMESG000019402.14.458e-3631.27SMESG000019402.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30009658 ID=SMED30009658|Name=UPF0565 protein C2orf69|organism=Schmidtea mediterranea sexual|type=transcript|length=1206bp
GCAAATGTCAAGTTTTTGTAAATATCTGGTCGAATTGCATAGATATGAAC
TGGGCAATTGTGTTTTTTATACCTTTCAAATAATTTACTAGCCGTTGATT
CAAGACTATAAACTTTATATATCTTCATGTTCTCATTCAGATCTTGGATA
TCACCACCAATATATATAACATTTAGATTAGGATTTCCTTTTCCTCCAAC
AAATACTATGTCATTACATCCTTTAATGCCATGAACATTTTTTAAAACCT
TAATTTTCATTTAAATATTTGTCATGTAAATCATCTCATTCAAAATTTTA
AATGAAAATTAAGGTTTTAAAAAATGTTCATGGCATTAAAGGATGTAATG
ACATAGTATTTGTTGGAGGAAAAGGAAATCCTAATCTAAATGTTATATAT
ATTGGTGGTGATATCCAAGATCTGAATGAGAACATGAAGATATATAAAGT
TTATAGTCTTGAATCAACGGCTAGTAAATTATTTGAAAGGTATAAAAAAC
ACAATTGCCCAGTTCATATCTATGCAATTCGACCAGATATTTACAAAAAC
TTGACATTTGCAATATATAATAACTTTGTTGATATGATCGAAGAAGGGAA
TCCAATATATAAATTCGATCCACTAAAGGGTGCTGCAAATCAGTTCCAAA
GTCTGATTACTTCATGTGTAAAAATGCTATTGGAAGATAAATCACTTACA
GTATTTCCTAAAATTGATATACCTCTTCATTTGATTGGTTTTAGTAAAGG
TTGCACAGTTTTAACTCAGTTACTTTACGATTTATCTCAAGTTCAAGATT
TTAAAATATATAAATTGTTTACCAATATTCTTGATATGTATTGGTTGGAT
TCGGGTCATAATGGTAATGCTGAACTATGGCCAACATCAGAGAACATTCT
TTCTAATTTTTTAAAAAATTTTAATTGCCGTATTCATGGATTCGGAACAC
CCTTTCAACTTTGTAGATTAAATAGAGAACGCTCTTTCGTTGAATACGAA
AAGTTTGAAAAAATTCTGCGAGTAATAAATCCTAAAAATCAATGTGGATT
TTTACTCAAGGAAGAAAATAATACTTTAGAAACACATTTTAAAGTTATTG
ACGTATTTCCACTGATTCTCGATGGCATAGAATTATAATTATCTTTTGGA
AATACATGATATCTAATAATCGCTATTTTAATTTGGATTTGTTCATTAAT
TCTAAC
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protein sequence of SMED30009658-orf-1

>SMED30009658-orf-1 ID=SMED30009658-orf-1|Name=SMED30009658-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=279bp
MKIKVLKNVHGIKGCNDIVFVGGKGNPNLNVIYIGGDIQDLNENMKIYKV
YSLESTASKLFERYKKHNCPVHIYAIRPDIYKNLTFAIYNNFVDMIEEGN
PIYKFDPLKGAANQFQSLITSCVKMLLEDKSLTVFPKIDIPLHLIGFSKG
CTVLTQLLYDLSQVQDFKIYKLFTNILDMYWLDSGHNGNAELWPTSENIL
SNFLKNFNCRIHGFGTPFQLCRLNRERSFVEYEKFEKILRVINPKNQCGF
LLKEENNTLETHFKVIDVFPLILDGIEL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR018881UPF0565
Vocabulary: molecular function
TermDefinition
GO:0003674molecular_function
Vocabulary: cellular component
TermDefinition
GO:0005576extracellular region
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR018881Uncharacterised protein family UPF0565PFAMPF10561UPF0565coord: 141..243
e-value: 9.1E-25
score: 87.5
coord: 9..122
e-value: 1.8E-8
score: 34.0
IPR018881Uncharacterised protein family UPF0565PANTHERPTHR31296FAMILY NOT NAMEDcoord: 8..269