RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Overview
NameRNA polymerase II subunit A C-terminal domain phosphatase SSU72
Smed IDSMED30009636
Length (bp)699
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SMED30009636) t-SNE clustered cells

Violin plots show distribution of expression levels for RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SMED30009636) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SMED30009636) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SMED30009636) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30009636

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
posterior sideSMED30009636h1SMcG0010470 dd_Smed_v4_3141_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30009636h1SMcG0010470 dd_Smed_v4_3141_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Human
Match: SSU72 (SSU72 homolog, RNA polymerase II CTD phosphatase [Source:HGNC Symbol;Acc:HGNC:25016])

HSP 1 Score: 257.299 bits (656), Expect = 4.832e-87
Identity = 115/193 (59.59%), Postives = 159/193 (82.38%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            SS +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTYD M+++L ++DK LYTQNG+L+ML+RN+RIK +PERFQ+  +LFD+I+T EERVYD V+E L +R+ +   +PVH++N+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F E S R  LHTV FY
Sbjct:    3 SSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETC-QPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Human
Match: SSU72P2 (SSU72 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:43621])

HSP 1 Score: 203.371 bits (516), Expect = 7.945e-66
Identity = 98/194 (50.52%), Postives = 141/194 (72.68%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            +SS +++AVVC SN NRSMEAH  L KKG  V+SFG  S V+LPGP  + P ++ F TTY  M+++L ++D+  YT+NG+L++L RN RIK  PERFQ+ T+ FDVI T EE VYD V+E L +R+ +   +PVH+IN++IQD  E+ATLGAFLIC++   + QSDD++++++E++    E + +  LHTV FY
Sbjct:    2 LSSTLRVAVVCVSNVNRSMEAHSILRKKGLSVRSFGTESHVRLPGPRPNRPVVYDFATTYKEMYNDLLRKDRECYTRNGILHILGRNERIKPGPERFQECTDFFDVIFTCEESVYDTVVEDLCSREQQT-FQPVHVINMEIQDTLEDATLGAFLICEICQCLQQSDDMEDNLEELLLQMEEKAGKSFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Human
Match: SSU72P3 (SSU72 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:43622])

HSP 1 Score: 203.371 bits (516), Expect = 9.356e-66
Identity = 99/194 (51.03%), Postives = 141/194 (72.68%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            +SS +++AVVC SN NRSMEAH  L +KG  V+SFG  S V+LPGP  + P ++ F TTY  M+++L ++D+  YT+NG+L++L RN RIK  PERFQ+ T+ FDVI T EE VYD V+E L +R+ +   +PVH+IN+DIQD  E+ATLGAFLIC++   + QSDDI+++++E++    E + +  LHTV FY
Sbjct:    2 LSSPLRVAVVCVSNVNRSMEAHSILRRKGLSVRSFGTESHVRLPGPRPNRPVVYDFATTYKQMYNDLLRKDRERYTRNGILHILGRNERIKPGPERFQECTDSFDVIFTCEESVYDTVVEDLCSREQQT-FQPVHVINMDIQDTLEDATLGAFLICEICQCLQQSDDIEDNLEELLLQMEEKAGKSFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Human
Match: SSU72P4 (SSU72 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:43623])

HSP 1 Score: 202.986 bits (515), Expect = 1.078e-65
Identity = 98/194 (50.52%), Postives = 141/194 (72.68%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            +SS +++AVVC SN NRSMEAH  L +KG  V+SFG  S V+LPGP  + P ++ F TTY  M+++L ++D+  YT+NG+L++L RN RIK  PERFQ+ T+ FDVI T EE VYD V+E L +R+ +   +PVH+IN+DIQD  E+ATLGAFLIC++   + QSDD++++++E++    E + +  LHTV FY
Sbjct:    2 LSSTLRVAVVCVSNVNRSMEAHSILRRKGLSVRSFGTESHVRLPGPRPNRPVVYDFATTYKEMYNDLLRKDRERYTRNGILHILGRNERIKPGPERFQECTDFFDVIFTCEESVYDTVVEDLCSREQQT-FQPVHVINMDIQDTLEDATLGAFLICEICQCLQQSDDMEDNLEELLLQMEEKAGKSFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Human
Match: SSU72P7 (SSU72 pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:43626])

HSP 1 Score: 201.445 bits (511), Expect = 4.697e-65
Identity = 97/194 (50.00%), Postives = 141/194 (72.68%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            +SS +++AVVC SN NRSMEAH  L +KG  V+SFG  S V+LPGP  + P ++ F TTY  M+++L ++D+  YT+NG+L++L RN RIK  PERFQ+ T+ FDVI T EE VYD V+E L +R+ +   +PVH+IN++IQD  E+ATLGAFLIC++   + QSDD++++++E++    E + +  LHTV FY
Sbjct:    2 LSSTLRVAVVCVSNVNRSMEAHSILRRKGLSVRSFGTESHVRLPGPRPNRPVVYDFATTYKEMYNDLLRKDRERYTRNGILHILGRNERIKPGPERFQECTDFFDVIFTCEESVYDTVVEDLCSREQQT-FQPVHVINMEIQDTLEDATLGAFLICEICQCLQQSDDMEDNLEELLLQMEEKAGKSFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Celegans
Match: ssup-72 (SSU (Yeast Suppressor of SUa7) Protein homolog [Source:UniProtKB/TrEMBL;Acc:Q22453])

HSP 1 Score: 206.453 bits (524), Expect = 2.691e-67
Identity = 99/197 (50.25%), Postives = 145/197 (73.60%), Query Frame = 2 
Query:   53 DMSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSF-ETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHS-NRHLLHTVSFY 637
            + SS ++ AV CSSN NRSMEAH  L K+G+ ++S+G G+QVK+PGP+  +PN + F  TTY+ ++ +L+ +D  LYTQNG+L+M++RNRRIKS+P+RFQ  T  FD+++ +EERV+D V++ L     K G+ PVH+INIDI+DN EEAT GAF + DL   + +S+D + DID++I    E++  R+LLHT+ FY
Sbjct:    2 EYSSKLRFAVSCSSNMNRSMEAHGILKKRGFNIESYGSGNQVKMPGPTVDKPNCYEFGPTTYEDIYADLTNKDLHLYTQNGLLHMVDRNRRIKSRPQRFQAETREFDIVLCLEERVFDQVVDFLNRSVGKSGN-PVHVINIDIEDNAEEATFGAFFVADLCEKLERSEDFEEDIDQIITDLEENNPKRNLLHTICFY 197
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Fly
Match: Ssu72 (gene:FBgn0031054 transcript:FBtr0074747)

HSP 1 Score: 233.032 bits (593), Expect = 9.190e-78
Identity = 109/195 (55.90%), Postives = 150/195 (76.92%), Query Frame = 2 
Query:   62 SDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVV---LECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            S + +AVVCSSN NRSMEAH+FL KKG+ V+S+G G +VKLPG +  +PN++ F T Y+ ++ +L  +DK  YTQNG+L+ML+RNRRIK  PERFQD+ E FD+IVTVEERVYD+V   +E +E+ DN    RPVH++N+D+ DN E+A +GAF+I D+++M+ +S D+DNDIDE+IQ F E   R +LH+V FY
Sbjct:    5 SKLAVAVVCSSNMNRSMEAHNFLAKKGFNVRSYGTGERVKLPGMAFDKPNVYEFGTKYEDIYRDLESKDKEFYTQNGLLHMLDRNRRIKKCPERFQDTKEQFDIIVTVEERVYDLVVMHMESMESVDN----RPVHVLNVDVVDNAEDALMGAFVITDMINMMAKSTDLDNDIDELIQEFEERRKRVILHSVLFY 195
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Fly
Match: Ssu72 (gene:FBgn0031054 transcript:FBtr0344152)

HSP 1 Score: 233.032 bits (593), Expect = 9.190e-78
Identity = 109/195 (55.90%), Postives = 150/195 (76.92%), Query Frame = 2 
Query:   62 SDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVV---LECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            S + +AVVCSSN NRSMEAH+FL KKG+ V+S+G G +VKLPG +  +PN++ F T Y+ ++ +L  +DK  YTQNG+L+ML+RNRRIK  PERFQD+ E FD+IVTVEERVYD+V   +E +E+ DN    RPVH++N+D+ DN E+A +GAF+I D+++M+ +S D+DNDIDE+IQ F E   R +LH+V FY
Sbjct:    5 SKLAVAVVCSSNMNRSMEAHNFLAKKGFNVRSYGTGERVKLPGMAFDKPNVYEFGTKYEDIYRDLESKDKEFYTQNGLLHMLDRNRRIKKCPERFQDTKEQFDIIVTVEERVYDLVVMHMESMESVDN----RPVHVLNVDVVDNAEDALMGAFVITDMINMMAKSTDLDNDIDELIQEFEERRKRVILHSVLFY 195
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Fly
Match: Ssu72 (gene:FBgn0031054 transcript:FBtr0332889)

HSP 1 Score: 228.024 bits (580), Expect = 9.225e-76
Identity = 109/195 (55.90%), Postives = 150/195 (76.92%), Query Frame = 2 
Query:   62 SDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVV---LECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            S + +AVVCSSN NRSMEAH+FL KKG+ V+S+G G +VKLPG +  +PN++ F T Y+ ++ +L  +DK  YTQNG+L+ML+RNRRIK  PERFQD+ E FD+IVTVEERVYD+V   +E +E+ DN    RPVH++N+D+ DN E+A +GAF+I D+++M+ +S D+DNDIDE+IQ F E   R +LH+V FY
Sbjct:    5 SKLAVAVVCSSNMNRSMEAHNFLAKKGFNVRSYGTGERVKLPGMAFDKPNVYEFGTKYEDIYRDLESKDKD-YTQNGLLHMLDRNRRIKKCPERFQDTKEQFDIIVTVEERVYDLVVMHMESMESVDN----RPVHVLNVDVVDNAEDALMGAFVITDMINMMAKSTDLDNDIDELIQEFEERRKRVILHSVLFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Zebrafish
Match: ssu72 (SSU72 homolog, RNA polymerase II CTD phosphatase [Source:NCBI gene;Acc:393701])

HSP 1 Score: 251.521 bits (641), Expect = 5.303e-85
Identity = 113/190 (59.47%), Postives = 157/190 (82.63%), Query Frame = 2 
Query:   68 IKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PNI+ F+TTY+ M+++L ++DK LYTQNG+L+ML+RN+RIKS+PERFQ   + FD+++T EERVYD VLE L +R+ +   +PVH+IN+DIQDNHEEATLGAFLIC+L   I  +DD++N++DE++Q F E S+R  LH+V FY
Sbjct:    6 LRVAVVCSSNQNRSMEAHNILSKRGFDVRSFGTGTHVKLPGPAPDKPNIYDFKTTYEQMYNDLVRKDKELYTQNGILHMLDRNKRIKSRPERFQSCRDQFDLVITCEERVYDQVLEDLNSREQE-SFQPVHVINVDIQDNHEEATLGAFLICELCQCIQHTDDMENEMDELLQEFEEKSHRPFLHSVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Xenopus
Match: ssu72 (SSU72 homolog, RNA polymerase II CTD phosphatase [Source:NCBI gene;Acc:549018])

HSP 1 Score: 248.825 bits (634), Expect = 1.101e-83
Identity = 110/193 (56.99%), Postives = 157/193 (81.35%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            ++ +++AVVCSSNQNRSMEAH+ L+K+ + V+SFG G+ VKLPGP+  +PN++ F+TTY+ M+++L K+DK LYTQNG+L+ML+RNRRIK +PERFQ+  + FD+++T EERVYD V+E L +R+ +   +PVH+IN+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F + S R  LHT+ FY
Sbjct:    3 TAPLRVAVVCSSNQNRSMEAHNILSKRSFNVRSFGTGTHVKLPGPAPDKPNVYDFKTTYEQMYNDLLKKDKELYTQNGILHMLDRNRRIKPRPERFQNCKDNFDLVITCEERVYDQVVEELNSREQETC-QPVHVINVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEDKSGRTFLHTICFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Xenopus
Match: ssu72 (SSU72 homolog, RNA polymerase II CTD phosphatase [Source:NCBI gene;Acc:549018])

HSP 1 Score: 216.083 bits (549), Expect = 4.481e-71
Identity = 102/193 (52.85%), Postives = 145/193 (75.13%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            ++ +++AVVCSSNQNRSME      + G         + VKLPGP+  +PN++ F+TTY+ M+++L K+DK LYTQNG+L+ML+RNRRIK +PERFQ+  + FD+++T EERVYD V+E L +R+ +   +PVH+IN+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F + S R  LHT+ FY
Sbjct:    3 TAPLRVAVVCSSNQNRSME------RCG--------RTHVKLPGPAPDKPNVYDFKTTYEQMYNDLLKKDKELYTQNGILHMLDRNRRIKPRPERFQNCKDNFDLVITCEERVYDQVVEELNSREQETC-QPVHVINVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEDKSGRTFLHTICFY 180
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Mouse
Match: Ssu72 (Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) [Source:MGI Symbol;Acc:MGI:1916241])

HSP 1 Score: 259.61 bits (662), Expect = 4.019e-88
Identity = 116/193 (60.10%), Postives = 160/193 (82.90%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            SS +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTYD M+++L ++DK LYTQNG+L+ML+RN+RIK +PERFQ+ T+LFD+I+T EERVYD V+E L +R+ +   +PVH++N+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F E S R  LHTV FY
Sbjct:    3 SSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCTDLFDLILTCEERVYDQVVEDLNSREQETC-QPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRAFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Mouse
Match: Ssu72 (Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) [Source:MGI Symbol;Acc:MGI:1916241])

HSP 1 Score: 224.557 bits (571), Expect = 1.957e-74
Identity = 99/161 (61.49%), Postives = 137/161 (85.09%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMI 541
            SS +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTYD M+++L ++DK LYTQNG+L+ML+RN+RIK +PERFQ+ T+LFD+I+T EERVYD V+E L +R+ +   +PVH++N+DIQDNHEEATLGAFLIC+L   +
Sbjct:    3 SSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCTDLFDLILTCEERVYDQVVEDLNSREQETC-QPVHVVNVDIQDNHEEATLGAFLICELCQCV 162
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. UniProt/SwissProt
Match: sp|Q9CY97|SSU72_MOUSE (RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Mus musculus OX=10090 GN=Ssu72 PE=1 SV=1)

HSP 1 Score: 259.61 bits (662), Expect = 2.811e-87
Identity = 116/193 (60.10%), Postives = 160/193 (82.90%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            SS +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTYD M+++L ++DK LYTQNG+L+ML+RN+RIK +PERFQ+ T+LFD+I+T EERVYD V+E L +R+ +   +PVH++N+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F E S R  LHTV FY
Sbjct:    3 SSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCTDLFDLILTCEERVYDQVVEDLNSREQETC-QPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRAFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. UniProt/SwissProt
Match: sp|Q17QI2|SSU72_BOVIN (RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Bos taurus OX=9913 GN=SSU72 PE=2 SV=1)

HSP 1 Score: 257.684 bits (657), Expect = 1.565e-86
Identity = 116/193 (60.10%), Postives = 159/193 (82.38%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            SS +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTYD M+++L ++DK LYTQNG+L+ML+RN+RIK +PERFQ+  +LFD+I+T EERVYD V+E L +R+ +   +PVH+IN+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F E S R  LHTV FY
Sbjct:    3 SSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETC-QPVHVINVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. UniProt/SwissProt
Match: sp|Q4KLK9|SSU72_RAT (RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Rattus norvegicus OX=10116 GN=Ssu72 PE=2 SV=1)

HSP 1 Score: 257.299 bits (656), Expect = 2.246e-86
Identity = 115/193 (59.59%), Postives = 159/193 (82.38%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            SS +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTYD M+++L ++DK LYTQNG+L+ML+RN+RIK +PERFQ+  +LFD+I+T EERVYD V+E L +R+ +   +PVH++N+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F E S R  LHTV FY
Sbjct:    3 SSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETC-QPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRAFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. UniProt/SwissProt
Match: sp|Q9NP77|SSU72_HUMAN (RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Homo sapiens OX=9606 GN=SSU72 PE=1 SV=1)

HSP 1 Score: 257.299 bits (656), Expect = 2.321e-86
Identity = 115/193 (59.59%), Postives = 159/193 (82.38%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            SS +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTYD M+++L ++DK LYTQNG+L+ML+RN+RIK +PERFQ+  +LFD+I+T EERVYD V+E L +R+ +   +PVH++N+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F E S R  LHTV FY
Sbjct:    3 SSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETC-QPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. UniProt/SwissProt
Match: sp|Q5ZJQ7|SSU72_CHICK (RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Gallus gallus OX=9031 GN=SSU72 PE=2 SV=1)

HSP 1 Score: 256.529 bits (654), Expect = 5.044e-86
Identity = 115/193 (59.59%), Postives = 159/193 (82.38%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            SS +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTYD M+++L ++DK LYTQNG+L+ML+RN+RIK +PERFQ+  ++FD+I+T EERVYD V+E L +R+ +   +PVH+IN+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F E S R  LHTV FY
Sbjct:    3 SSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDVFDLILTCEERVYDQVVEDLNSREQETC-QPVHVINVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. TrEMBL
Match: V3ZTQ1 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_236282 PE=4 SV=1)

HSP 1 Score: 277.33 bits (708), Expect = 9.506e-92
Identity = 127/194 (65.46%), Postives = 163/194 (84.02%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            M S++K+AVVCSSNQNRSMEAH+FL+KKGY V+SFG G+QVKLPGPS  +PN + F  TYD MF +LS++D  LYTQNG+L+ML+RNRR+K KPERFQ+ ++ FD+I+T EERVYD V+E LENR+ K G + VHIINIDIQDNHEEAT+GAF+IC+LV+M+  SDD+DND+DE++Q F   + R +LHTV+FY
Sbjct:    1 MPSEVKVAVVCSSNQNRSMEAHNFLSKKGYSVRSFGTGNQVKLPGPSPDKPNNYDFNVTYDEMFKDLSQKDPELYTQNGILHMLDRNRRLKPKPERFQNCSDKFDIIMTCEERVYDQVIEDLENRE-KDGGQAVHIINIDIQDNHEEATIGAFMICELVAMLAISDDLDNDVDEIVQEFESQTKRTILHTVAFY 193
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. TrEMBL
Match: C3YRI6 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_121072 PE=4 SV=1)

HSP 1 Score: 266.159 bits (679), Expect = 2.296e-87
Identity = 126/196 (64.29%), Postives = 157/196 (80.10%), Query Frame = 2 
Query:   62 SDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKAL----YTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
             D+ IAVVCSSNQNRSMEAH FL+KKG+ VKSFG GSQVKLPGP+  +PN++ F TTYD M  +L+++D AL    YTQNG+L+ML+RN+RIK +PERFQ + E FD++VT EERVYD V+E LE RD+     PVH+INIDIQDNHEEAT+GAFLICDL  M+  SDD++N++DE++Q F E  NR +LHTVSFY
Sbjct:    2 GDLNIAVVCSSNQNRSMEAHAFLSKKGFRVKSFGTGSQVKLPGPAPDKPNVYDFGTTYDQMHKDLTQKDLALLKPRYTQNGILHMLDRNKRIKPRPERFQSAKERFDIVVTCEERVYDQVVEDLETRDSG-ADAPVHVINIDIQDNHEEATIGAFLICDLCQMLQDSDDLENEMDEILQAFEEKCNRPILHTVSFY 196
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. TrEMBL
Match: A0A4Y2GVC3 (RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Araneus ventricosus OX=182803 GN=SSU72 PE=4 SV=1)

HSP 1 Score: 265.774 bits (678), Expect = 2.818e-87
Identity = 121/194 (62.37%), Postives = 158/194 (81.44%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            M+SD+++AVVCSSNQNRSMEAH FL+KKG+ V+SFG G+QVKLPGP+  +PN++ F  +Y+ M+ +L  +DKALYTQNG+L+ML+RNRRIKS PERFQ   E FDVI TVEERVYD V+E L +R  K    P+HIINID+QDNHEEAT+GAFL+C++ +M+ +S+D+DNDIDE++Q F   + R +LHTV FY
Sbjct:    1 MTSDLRVAVVCSSNQNRSMEAHAFLSKKGFKVRSFGSGNQVKLPGPAPDKPNVYDFSISYEQMYQDLLAKDKALYTQNGLLHMLDRNRRIKSHPERFQSCYETFDVIFTVEERVYDQVVEELASRSPK-EISPIHIINIDVQDNHEEATIGAFLVCEMATMMAESEDLDNDIDELLQEFEAKAQRPILHTVQFY 193
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. TrEMBL
Match: A0A0B7API3 (Uncharacterized protein OS=Arion vulgaris OX=1028688 GN=ORF133465 PE=4 SV=1)

HSP 1 Score: 262.692 bits (670), Expect = 5.770e-86
Identity = 122/194 (62.89%), Postives = 157/194 (80.93%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            M++++KIAV+CSSNQNRSMEAH FL+KKG+ VKSFG G+ VKLPGP+  +PNI+ F  TYD M+ +L ++D  LYTQNG+L+ML+RNRRIK+ PERFQ S E FD+++T EERVYD VLE  ENRD     + VHIINIDIQDNHEEAT+GAF+IC+LV+M+  SDD+DN++DE++Q F    +R +LHTV FY
Sbjct:    1 MANELKIAVICSSNQNRSMEAHSFLSKKGFNVKSFGTGNMVKLPGPAPDKPNIYDFSITYDAMYRDLMQKDYELYTQNGILHMLDRNRRIKANPERFQLSKEKFDLVITCEERVYDQVLEDFENRDRN-DEQAVHIINIDIQDNHEEATIGAFMICELVTMLYASDDLDNEVDEILQEFEHKVSRTVLHTVQFY 193
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. TrEMBL
Match: A0A5F8G229 (Uncharacterized protein OS=Monodelphis domestica OX=13616 PE=4 SV=1)

HSP 1 Score: 261.922 bits (668), Expect = 1.019e-85
Identity = 118/194 (60.82%), Postives = 160/194 (82.47%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            M S +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTYD M+++L ++DK LYTQNG+L+ML+RNRRIK +PERFQ+  +LFD+I+T EERVYD V+E L +R+ +   +PVH+IN+DIQDNHEEATLGAFLIC+L   I  ++D++N+IDE++Q F E SNR  LHTV FY
Sbjct:    1 MQSSLRVAVVCSSNQNRSMEAHNILSKRGFNVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNRRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETC-QPVHVINVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSNRTFLHTVCFY 193
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Cavefish
Match: ssu72 (SSU72 homolog, RNA polymerase II CTD phosphatase [Source:NCBI gene;Acc:103043050])

HSP 1 Score: 253.062 bits (645), Expect = 1.085e-85
Identity = 114/193 (59.07%), Postives = 156/193 (80.83%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            S  +++AVVCSSNQNRSMEAH+ L+K+G+ V+SFG G+ VKLPGP+  +PN++ F+TTY+ M+ +L ++DK LYTQNG+L+MLERN+RIK +PERFQ   + FD+++T EERVYD VLE L +R+ +   +PVH+IN+DIQDNHEEATLGAFLIC+L   I  +DD++N+IDE++Q F + S+R  LHTV FY
Sbjct:    3 SQPLRVAVVCSSNQNRSMEAHNILSKRGFDVRSFGTGTHVKLPGPAPDKPNVYDFKTTYEQMYSDLVRKDKDLYTQNGILHMLERNKRIKQRPERFQSCKDQFDLVITCEERVYDQVLEDLNSREQET-FQPVHVINVDIQDNHEEATLGAFLICELCQCIQHTDDMENEIDELLQEFEDKSSRPFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Sea Lamprey
Match: ssu72 (SSU72 homolog, RNA polymerase II CTD phosphatase [Source:NCBI gene;Acc:393701])

HSP 1 Score: 246.128 bits (627), Expect = 1.393e-83
Identity = 115/192 (59.90%), Postives = 151/192 (78.65%), Query Frame = 2 
Query:   62 SDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            S +KIAVVCSSNQNRSMEAH  L+KKG+ V+SFG G+ VKLPGP+  +PN++ F+TTY+ M+ +L  +DK LYTQNG+L+MLERNRR+K +PERFQ   E FD+++T EERVYD VLE L +R+ +   +PVH+IN+DIQDNHE+ATLGAFL+ +    I  +DD+DNDIDE++Q F +   + LLHTV FY
Sbjct:    4 SSMKIAVVCSSNQNRSMEAHSVLSKKGFYVRSFGTGTHVKLPGPAPDKPNVYDFKTTYEQMYSDLVMKDKELYTQNGILHMLERNRRLKPRPERFQSCREHFDIVLTCEERVYDQVLEDLNSREQET-LQPVHVINVDIQDNHEDATLGAFLLLEKNQKIKLTDDVDNDIDELLQDFEDKCGKPLLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Sea Lamprey
Match: ssu72 (SSU72 homolog, RNA polymerase II CTD phosphatase [Source:NCBI gene;Acc:393701])

HSP 1 Score: 210.69 bits (535), Expect = 6.812e-70
Identity = 99/170 (58.24%), Postives = 133/170 (78.24%), Query Frame = 2 
Query:  131 NKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLEC-LENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            +KKG+ V+SFG G+ VKLPGPS  +PNI+ F+T YD M+ +L +RDK LYTQNG+L+ML+RNRRIK  PERFQ+  + FD+I+T EERVYD V+E  L  R+ +   +PVH+IN+D+QDNHE+ATLGAFLIC+L   I  ++D+DN+IDE++Q F E S + +LHTV FY
Sbjct:    1 SKKGFDVRSFGTGTHVKLPGPSPDKPNIYEFKTPYDAMYQDLLQRDKDLYTQNGILHMLDRNRRIKPCPERFQECPDRFDLILTCEERVYDQVVEADLSGREQE-SFQPVHVINVDVQDNHEDATLGAFLICELCQCIQLTEDLDNEIDELVQDFEEKSGKLILHTVCFY 169
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Yeast
Match: SSU72 (Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo [Source:SGD;Acc:S000005166])

HSP 1 Score: 165.236 bits (417), Expect = 7.872e-52
Identity = 85/202 (42.08%), Postives = 129/202 (63.86%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMI------VQSDDI---DNDIDEVIQHFSEHSNRHLLHTVSFY 637
            +S++K   VC+SN NRSME+H  L + GY V S+G GS V+LPG S  +PN++SF T Y+ ++++L  +    Y  NG+L ML+RNRR+K  PE++Q+ST++FD + T EER +D V E L NR  K+ ++ VH+IN+DI+D+ E A +G+  I +L  M+       + DDI   D  +D + +  S HS    L+  S+Y
Sbjct:    6 NSNLKFCTVCASNNNRSMESHKVLQEAGYNVSSYGTGSAVRLPGLSIDKPNVYSFGTPYNDIYNDLLSQSADRYKSNGLLQMLDRNRRLKKAPEKWQESTKVFDFVFTCEERCFDAVCEDLMNRGGKL-NKIVHVINVDIKDDDENAKIGSKAILELADMLNDKIEQCEKDDIPFEDCIMDILTEWQSSHSQLPSLYAPSYY 206
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Nematostella
Match: EDO39582 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9J1])

HSP 1 Score: 246.128 bits (627), Expect = 2.705e-83
Identity = 112/194 (57.73%), Postives = 157/194 (80.93%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            M   +KIAVVCSSNQNRSMEAH+FL+K+G+ VKS+G G+ VKLPGP+  +PNI++F+T YD M+ +L ++D ALYTQNG+L+ML+RNRRIK+ PERFQ++ E FD+I+T EERVYD V+E LE  D +  ++PVH++NIDI DNHEEATLGAFLIC++   I +  D++++I++V+  F +   R++LH+V+FY
Sbjct:    1 MVHKLKIAVVCSSNQNRSMEAHNFLSKRGFNVKSYGSGTHVKLPGPAPDKPNIYTFDTPYDEMYKDLLRKDSALYTQNGILHMLDRNRRIKALPERFQEAVEHFDLIITAEERVYDQVIEHLEGLDAQ-SYKPVHVVNIDILDNHEEATLGAFLICEICEAIEKLTDVEDEINDVVAKFEDKYKRNILHSVAFY 193
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Medaka
Match: ssu72 (SSU72 homolog, RNA polymerase II CTD phosphatase [Source:NCBI gene;Acc:101170572])

HSP 1 Score: 257.684 bits (657), Expect = 2.173e-87
Identity = 118/193 (61.14%), Postives = 157/193 (81.35%), Query Frame = 2 
Query:   59 SSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            S  +++AVVCSSNQNRSMEAH  L+K+G+ V+SFG GS VKLPGP+  +PN++ F+TTY+ M+++L ++DK LYTQNG+L+ML+RN+RIKSKPERFQ   E FD+++T EERVYD VLE L +R+ +   +PVH+IN+DIQDNHEEATLGAFLIC+L   I  +DD++N+IDE++Q F + SNR  LHTV FY
Sbjct:    3 SHPLRVAVVCSSNQNRSMEAHSILSKRGFEVRSFGTGSHVKLPGPAPDKPNVYDFKTTYEQMYNDLVRKDKELYTQNGILHMLDRNKRIKSKPERFQLCKEKFDLVITCEERVYDQVLEDLNSREQET-MQPVHVINVDIQDNHEEATLGAFLICELCQCIQHTDDMENEIDELLQEFEDKSNRPFLHTVCFY 194
[Close]
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Planmine SMEST
Match: SMESG000002994.1 (SMESG000002994.1)

HSP 1 Score: 400.208 bits (1027), Expect = 6.167e-144
Identity = 194/194 (100.00%), Postives = 194/194 (100.00%), Query Frame = 2 
Query:   56 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 637
            MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY
Sbjct:    1 MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSEPNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDSTELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATLGAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY 194
The following BLAST results are available for this feature:
BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SSU724.832e-8759.59SSU72 homolog, RNA polymerase II CTD phosphatase [... [more]
SSU72P27.945e-6650.52SSU72 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:43... [more]
SSU72P39.356e-6651.03SSU72 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:43... [more]
SSU72P41.078e-6550.52SSU72 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:43... [more]
SSU72P74.697e-6550.00SSU72 pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:43... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ssup-722.691e-6750.25SSU (Yeast Suppressor of SUa7) Protein homolog [S... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Ssu729.190e-7855.90gene:FBgn0031054 transcript:FBtr0074747[more]
Ssu729.190e-7855.90gene:FBgn0031054 transcript:FBtr0344152[more]
Ssu729.225e-7655.90gene:FBgn0031054 transcript:FBtr0332889[more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ssu725.303e-8559.47SSU72 homolog, RNA polymerase II CTD phosphatase [... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ssu721.101e-8356.99SSU72 homolog, RNA polymerase II CTD phosphatase [... [more]
ssu724.481e-7152.85SSU72 homolog, RNA polymerase II CTD phosphatase [... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Ssu724.019e-8860.10Ssu72 RNA polymerase II CTD phosphatase homolog (y... [more]
Ssu721.957e-7461.49Ssu72 RNA polymerase II CTD phosphatase homolog (y... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9CY97|SSU72_MOUSE2.811e-8760.10RNA polymerase II subunit A C-terminal domain phos... [more]
sp|Q17QI2|SSU72_BOVIN1.565e-8660.10RNA polymerase II subunit A C-terminal domain phos... [more]
sp|Q4KLK9|SSU72_RAT2.246e-8659.59RNA polymerase II subunit A C-terminal domain phos... [more]
sp|Q9NP77|SSU72_HUMAN2.321e-8659.59RNA polymerase II subunit A C-terminal domain phos... [more]
sp|Q5ZJQ7|SSU72_CHICK5.044e-8659.59RNA polymerase II subunit A C-terminal domain phos... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
V3ZTQ19.506e-9265.46Uncharacterized protein OS=Lottia gigantea OX=2251... [more]
C3YRI62.296e-8764.29Uncharacterized protein OS=Branchiostoma floridae ... [more]
A0A4Y2GVC32.818e-8762.37RNA polymerase II subunit A C-terminal domain phos... [more]
A0A0B7API35.770e-8662.89Uncharacterized protein OS=Arion vulgaris OX=10286... [more]
A0A5F8G2291.019e-8560.82Uncharacterized protein OS=Monodelphis domestica O... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ssu721.085e-8559.07SSU72 homolog, RNA polymerase II CTD phosphatase [... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ssu721.393e-8359.90SSU72 homolog, RNA polymerase II CTD phosphatase [... [more]
ssu726.812e-7058.24SSU72 homolog, RNA polymerase II CTD phosphatase [... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
SSU727.872e-5242.08Phosphatase and transcription/RNA-processing facto... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO395822.705e-8357.73Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ssu722.173e-8761.14SSU72 homolog, RNA polymerase II CTD phosphatase [... [more]
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BLAST of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000002994.16.167e-144100.00SMESG000002994.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30009636 ID=SMED30009636|Name=RNA polymerase II subunit A C-terminal domain phosphatase SSU72|organism=Schmidtea mediterranea sexual|type=transcript|length=699bp
GTTTTAGTCCTACATTTTAAACTTTGTAAACTAATTGAATTTTGTAAACT
GAGACATGTCATCTGATATTAAAATTGCTGTTGTTTGTTCTAGTAATCAA
AATAGAAGTATGGAAGCACATCATTTTCTAAACAAAAAAGGCTATCTTGT
AAAATCATTTGGGATTGGATCACAAGTCAAACTTCCAGGACCTAGTCAAA
GTGAACCGAACATTTTTTCATTTGAAACAACATATGATCATATGTTTGAC
GAATTATCTAAACGAGATAAAGCATTATATACCCAAAATGGGGTATTAAA
TATGCTTGAACGTAATCGCCGGATAAAATCTAAGCCTGAAAGATTTCAGG
ATTCGACAGAACTTTTTGACGTAATTGTTACAGTAGAGGAAAGAGTATAT
GACGTTGTTTTAGAATGTTTGGAGAACAGGGATAATAAAATAGGTCACCG
TCCTGTTCATATTATAAATATTGATATTCAAGATAACCACGAAGAAGCGA
CTCTAGGAGCATTTTTGATATGTGATTTAGTTTCTATGATTGTTCAAAGT
GACGATATAGACAATGATATAGATGAAGTTATACAGCATTTCTCAGAGCA
TTCAAATAGACATCTATTGCATACTGTCTCATTTTACTAAAAAATATAAA
TATTTTTACATTAAACGTTCTATTTAATTTAGTAAAATTTTAACCGAGA
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protein sequence of SMED30009636-orf-1

>SMED30009636-orf-1 ID=SMED30009636-orf-1|Name=SMED30009636-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=195bp
MSSDIKIAVVCSSNQNRSMEAHHFLNKKGYLVKSFGIGSQVKLPGPSQSE
PNIFSFETTYDHMFDELSKRDKALYTQNGVLNMLERNRRIKSKPERFQDS
TELFDVIVTVEERVYDVVLECLENRDNKIGHRPVHIINIDIQDNHEEATL
GAFLICDLVSMIVQSDDIDNDIDEVIQHFSEHSNRHLLHTVSFY*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0006470protein dephosphorylation
GO:0006397mRNA processing
GO:0006369termination of RNA polymerase II transcription
GO:0006378mRNA polyadenylation
GO:0070940dephosphorylation of RNA polymerase II C-terminal domain
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR006811RNA_pol_II_suA
Vocabulary: molecular function
TermDefinition
GO:0004721phosphoprotein phosphatase activity
GO:0008420CTD phosphatase activity
GO:0016787hydrolase activity
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005737cytoplasm
GO:0005829cytosol
GO:0005847mRNA cleavage and polyadenylation specificity factor complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR006811RNA polymerase II subunit APFAMPF04722Ssu72coord: 6..194
e-value: 1.7E-80
score: 269.1
IPR006811RNA polymerase II subunit APANTHERPTHR20383FAMILY NOT NAMEDcoord: 2..194
NoneNo IPR availableGENE3DG3DSA:3.40.50.2300coord: 1..75
e-value: 9.8E-16
score: 59.7
NoneNo IPR availableGENE3DG3DSA:3.40.50.2300coord: 76..194
e-value: 1.9E-42
score: 146.3
NoneNo IPR availablePANTHERPTHR20383:SF11RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72coord: 2..194