methionine synthase reductase

Overview


Name	methionine synthase reductase
Smed ID	SMED30009557
Length (bp)	2263

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of methionine synthase reductase (SMED30009557) t-SNE clustered cells

Violin plots show distribution of expression levels for methionine synthase reductase (SMED30009557) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of methionine synthase reductase (SMED30009557) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for methionine synthase reductase (SMED30009557) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30009557

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
posterior side	SMED30009557	SMESG000061482.1	dd_Smed_v4_3947_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30009557	SMESG000061482.1	dd_Smed_v4_3947_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

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BLAST of methionine synthase reductase vs. Ensembl Human
Match: MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:HGNC Symbol;Acc:HGNC:7473])

HSP 1 Score: 334.724 bits (857), Expect = 1.107e-103
Identity = 240/724 (33.15%), Postives = 381/724 (52.62%), Query Frame = 2

Query:   62 LKMTCILYGSQTGQAKSIAENL--YAKLKDYIKHIN-IFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAK----------DMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNN-EDSISNFHEPLI-TSMPMPSSDSELVMGEVQD------------------------ITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV------SFAFSKVDI---APIQTFRKRPLTGVCTSWMEKMAK------FHNEQ-------IWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNE--NQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ++   +LY +Q GQAK+IAE +   A +  +   ++ I E D  +   E   L   +++ STTG GD PD A KF++ I+       + ++ +Y +LGLGD+ Y+ FCN  K ID+ L+  GAR FY +  ADD VGLE+VVEPW+ GL+   +          ++   +P+      S    + K E+  IE+  ELL    +   D + L   A+ S   N++  + E S++    PL   S+ +P    E +   +Q+                          ++T   AIK+     +++ N  + ++PGD+  ++  N++SEV S+L RL + +  ++CV+     +  +   A +P+H+        SL+ I  W  ++R    K  LR + +Y    SAE+RRL ELCS++G + Y++ +R+    +LDLL  FPSCQ P+  LLE LP+L+PR YS C   S+       F F+ V+    A  +  RK    GVCT W+  +         H            KI I  R   N F + ++PSIP I++GPGTG+APFIGFLQ+ EKL+ +  + N G +WLFFGCR+++RD++F+K+L HF   GILTHL V FSRD P   G+E+         KYVQ  +  H + ++ +L+ +N  ++VCGD+  M+KDV +    ++  + E    K +A   +  ++ +K YL+D+W
Sbjct:    1 MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPL---VVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS--PASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKG-ATLPQHI----PAGCSLQFIFTWCLEIRAIPKKAFLRALVDYT-SDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYS-CASSSLFHPGKLHFVFNIVEFLSTATTEVLRK----GVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPR-TTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPV--GEEEA------PAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQII--SKEVGVEKLEAMKTLATLKEEKRYLQDIW 697

[Close]

BLAST of methionine synthase reductase vs. Ensembl Human
Match: MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:HGNC Symbol;Acc:HGNC:7473])

HSP 1 Score: 335.495 bits (859), Expect = 1.223e-103
Identity = 245/736 (33.29%), Postives = 385/736 (52.31%), Query Frame = 2

Query:   50 LCDFLKMTCI--------LYGSQTGQAKSIAENL--YAKLKDYIKHIN-IFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAK----------DMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNN-EDSISNFHEPLI-TSMPMPSSDSELVMGEVQD------------------------ITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV------SFAFSKVDI---APIQTFRKRPLTGVCTSWMEKMAK------FHNEQ-------IWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNE--NQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            LC F  +TC+        LY +Q GQAK+IAE +   A +  +   ++ I E D  +   E   L   +++ STTG GD PD A KF++ I+       + ++ +Y +LGLGD+ Y+ FCN  K ID+ L+  GAR FY +  ADD VGLE+VVEPW+ GL+   +          ++   +P+      S    + K E+  IE+  ELL    +   D + L   A+ S   N++  + E S++    PL   S+ +P    E +   +Q+                          ++T   AIK+     +++ N  + ++PGD+  ++  N++SEV S+L RL + +  ++CV+     +  +   A +P+H+        SL+ I  W  ++R    K  LR + +Y    SAE+RRL ELCS++G + Y++ +R+    +LDLL  FPSCQ P+  LLE LP+L+PR YS C   S+       F F+ V+    A  +  RK    GVCT W+  +         H            KI I  R   N F + ++PSIP I++GPGTG+APFIGFLQ+ EKL+ +  + N G +WLFFGCR+++RD++F+K+L HF   GILTHL V FSRD P   G+E+         KYVQ  +  H + ++ +L+ +N  ++VCGD+  M+KDV +    ++  + E    K +A   +  ++ +K YL+D+W
Sbjct:   17 LCSF-TVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPL---VVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS--PASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKG-ATLPQHI----PAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTS-DSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYS-CASSSLFHPGKLHFVFNIVEFLSTATTEVLRK----GVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPR-TTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPV--GEEEA------PAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQII--SKEVGVEKLEAMKTLATLKEEKRYLQDIW 724

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BLAST of methionine synthase reductase vs. Ensembl Human
Match: POR (cytochrome p450 oxidoreductase [Source:HGNC Symbol;Acc:HGNC:9208])

HSP 1 Score: 182.185 bits (461), Expect = 5.841e-48
Identity = 171/668 (25.60%), Postives = 291/668 (43.56%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDY-IKHINI----FELDDVEKSFEIHKLNFAIIIC-STTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVP-ALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQR-RLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV---SFAFSKVDIAPIQTFRKRPLTGVCTSWME-KMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVL--LGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + YGSQTG A+  A  L      Y ++ ++     ++L D+    EI   N  ++ C +T G+GD  DNA  F   ++      LS  K+ V GLG+  Y +F    K +D+ LE  GA+R +   + DD   LE     W +  +     +C    ++     S   +   +    I+  K  +G+ + +    +N   P    +PFL  +  N                                 +  N+   + +    +++ ++K +++ GD V + P N  + V+ +   L     + + V+ L  L+   N++   P           S ++ L +  D+  P     L  +++Y    S ++  R +   S EG+  Y   + E    +L +L   PS + PI  L E+LPRL+ R YS+     V   S     V +   +T   R   GV T+W+  K     N     +P+++RK+   F +    + P I++GPGTGVAPFIGF+Q    L+ + + +G   L++GCR  + D++++++L  F   G LT L V FSR+                   YVQH L    + L   L+   A ++VCGD+  M++DV  T+ +++  LG  E  Q    A  +I  +  +  Y  DVW
Sbjct:   85 VFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEID--NALVVFCMATYGEGDPTDNAQDFYDWLQETDVD-LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPA---VCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGE-MGRLKSYENQKPPFDAKNPFLAAVTTN---------------------------------RKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGA---DLDVVMSLNNLDEESNKKHPFP--------CPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAV-VVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQ--FRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKV--------------YVQHLLKQDREHLWK-LIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQ----AVDYIKKLMTKGRYSLDVW 679

[Close]

BLAST of methionine synthase reductase vs. Ensembl Human
Match: POR (cytochrome p450 oxidoreductase [Source:HGNC Symbol;Acc:HGNC:9208])

HSP 1 Score: 164.466 bits (415), Expect = 4.385e-42
Identity = 156/618 (25.24%), Postives = 266/618 (43.04%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDY-IKHINI----FELDDVEKSFEIHKLNFAIIIC-STTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVP-ALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQR-RLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV---SFAFSKVDIAPIQTFRKRPLTGVCTSWME-KMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCG 1894
            + YGSQTG A+  A  L      Y ++ ++     ++L D+    EI   N  ++ C +T G+GD  DNA  F   ++      LS  K+ V GLG+  Y +F    K +D+ LE  GA+R +   + DD   LE     W +  +     +C    ++     S   +   +    I+  K  +G+ + +    +N   P    +PFL  +  N                                 +  N+   + +    +++ ++K +++ GD V + P N  + V+ +   L     + + V+ L  L+   N++   P           S ++ L +  D+  P     L  +++Y    S ++  R +   S EG+  Y   + E    +L +L   PS + PI  L E+LPRL+ R YS+     V   S     V +   +T   R   GV T+W+  K     N     +P+++RK+   F +    + P I++GPGTGVAPFIGF+Q    L+ + + +G   L++GCR  + D++++++L  F   G LT L V FSR+                   YVQH L    + L   L+   A ++VCG
Sbjct:   85 VFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEID--NALVVFCMATYGEGDPTDNAQDFYDWLQETDVD-LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPA---VCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGE-MGRLKSYENQKPPFDAKNPFLAAVTTN---------------------------------RKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGA---DLDVVMSLNNLDEESNKKHPFP--------CPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAV-VVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQ--FRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKV--------------YVQHLLKQDREHLWK-LIEGGAHIYVCG 633

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BLAST of methionine synthase reductase vs. Ensembl Human
Match: NDOR1 (NADPH dependent diflavin oxidoreductase 1 [Source:HGNC Symbol;Acc:HGNC:29838])

HSP 1 Score: 154.066 bits (388), Expect = 1.049e-38
Identity = 162/670 (24.18%), Postives = 286/670 (42.69%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDA--VGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMP---MPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQS-FYTKCLRETSMPVLDLLNWFP--SCQIPIVRLLEVLPRLKPRAYSLCD--LESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKL-KNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPT---NSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +L+GSQTG A+ ++E L  + +       +  LD       I++    I +C+TTG GD PDN   F R I  K      L    + VLGLGD++Y+ F   +K + + L   G        + DD   +G +  V+PWL  L++                                    +LG  L     G     P +P P    +   +++ S   E    + P    P S+S+  +  +    ++T     + V     ++  +   +  GD V I P N+ + V      L +   + + +  L+  E   +   ++P+          S++ ++    D+     +    +++    +   E+ +LLE  S +GQ   +  C R     +L++L  FP  +  IP   LL+++P ++PRA+S+    L   S     V +   QT  K P  G+C+SW+  +     +   ++P+++R     F   E P  P I++GPGTGVAPF   +Q  E++ + +  N    +LFFGCR  ++DF ++ + +       LT L   FSR+ P    ++  EQK         YVQH L     ++ +LL  Q A  ++ G++  M  DV E   ++     E      DA +++  ++  + +  + W
Sbjct:    8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE-PLVIFVCATTGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWD-----------------------------------RVLG--LYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGL---DPDQLFMLQPREPDVSSPTRLPQ--------PCSMRHLVSHYLDIASVPRRSFFELLACLS-LHELEREKLLEFSSAQGQEELFEYCNRPRRT-ILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSSWLASLDP--GQGPVRVPLWVRPGSLAFP--ETPDTPVIMVGPGTGVAPFRAAIQ--ERVAQGQTGN----FLFFGCRWRDQDFYWEAEWQELEKRDCLT-LIPAFSREQPPALFSALQEQK--------VYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIF--QEEGGLCSPDAAAYLARLQQTRRFQTETW 605

[Close]

BLAST of methionine synthase reductase vs. Ensembl Celegans
Match: mtrr-1 (Methionine synthase reductase [Source:UniProtKB/Swiss-Prot;Acc:Q17574])

HSP 1 Score: 268.855 bits (686), Expect = 1.736e-79
Identity = 212/720 (29.44%), Postives = 352/720 (48.89%), Query Frame = 2

Query:   50 LCDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELL--------------GDHLAKDM---------------------DGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSM------PMPSSDSELVMGEVQDITKITNKYA--IKSVHRATINVPN--AKWKWKPGDSVGILPFNAESEVDSILSRLSVPE-TEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLES--VSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIW-KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN---IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHH-SKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNH--EKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + DFL    I +GSQTGQA++IA++L  K +       +  LD+ EK F +++     I+ S+TGDGDAPDN ++F+R I     + +YL N  Y +LGLGD+NYS++    + ID+ L + GA R +    ADD VGLE+ VEPW++  +        +I  D    ++ +  +   ++K  E  K LL              G  +  DM                     + +NL VP  P PF+        S+SN   P  T +       MP   ++     V     +T+ ++  IK+    T++  +  A+ +++PGD++     N   EV+ IL R  V +  ++ C + +       N  A++P H+    +   +L+ +     D+R+   +  +R+++E       E+RRLLELCS +G   +T  +R   + + D+L  FP+ + P+ RL+E+LPRL PR YS+   E+      +S+++  P    R+    G+ T W+  +      Q+  K P   R    G T      +P +++GPGTGV+ F+ FL +  KLK ++ +     P  LFFGCR+   D I+  +LE F + GILT L +C S         EQK        + VQ  L  +  K+L  L  +  +++F+CGD+ GMSKDV + +S+++  +     ++ K+     +  ++    Y+EDVW
Sbjct:    1 MTDFL----IAFGSQTGQAETIAKSLKEKAELIGLTPRLHALDENEKKFNLNEEKLCAIVVSSTGDGDAPDNCARFVRRINRNSLENEYLKNLDYVLLGLGDSNYSSYQTIPRKIDKQLTALGANRLFDRAEADDQVGLELEVEPWIEKFFATLASRF-DISADKMNAITESSNLKLNQVKTEEEKKALLQKRIEDEESDDEGRGRVIGIDMLIPEHYDYPEISLLKGSQTLSNDENLRVPIAPQPFIV------SSVSNRKLPEDTKLEWQNLCKMPGVVTKPFEVLVVSAEFVTDPFSKKIKTKRMITVDFGDHAAELQYEPGDAIYFCVPNPALEVNFILKRCGVLDIADQQCELSINPKTEKIN--AQIPGHV----HKITTLRHMFTTCLDIRRAPGRPLIRVLAESTS-DPNEKRRLLELCSAQGMKDFTDFVRTPGLSLADMLFAFPNVKPPVDRLIELLPRLIPRPYSMSSYENRKARLIYSEMEF-PATDGRRHSRKGLATDWLNSLRIGDKVQVLGKEPARFRLPPLGMTKNSAGKLPLLMVGPGTGVSVFLSFLHFLRKLKQDSPSDFVDVPRVLFFGCRDSSVDAIYMSELEMFVSEGILTDLIICES---------EQKG-------ERVQDGLRKYLDKVLPFLTASTESKIFICGDAKGMSKDVWQCFSDIVASDQGIPDLEAKKK----LMDLKKSDQYIEDVW 681

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Query:   50 LCDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELL--------------GDHLAKDM---------------------DGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSM------PMPSSDSELVMGEVQDITKITNKYA--IKSVHRATINVPN--AKWKWKPGDSVGILPFNAESEVDSILSRLSVPE-TEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLES--VSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIW-KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN---IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHH-SKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNH--EKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + DFL    I +GSQTGQA++IA++L  K +       +  LD+ EK F +++     I+ S+TGDGDAPDN ++F+R I     + +YL N  Y +LGLGD+NYS++    + ID+ L + GA R +    ADD VGLE+ VEPW++  +        +I  D    ++ +  +   ++K  E  K LL              G  +  DM                     + +NL VP  P PF+        S+SN   P  T +       MP   ++     V     +T+ ++  IK+    T++  +  A+ +++PGD++     N   EV+ IL R  V +  ++ C + +       N  A++P H+    +   +L+ +     D+R+   +  +R+++E       E+RRLLELCS +G   +T  +R   + + D+L  FP+ + P+ RL+E+LPRL PR YS+   E+      +S+++  P    R+    G+ T W+  +      Q+  K P   R    G T      +P +++GPGTGV+ F+ FL +  KLK ++ +     P  LFFGCR+   D I+  +LE F + GILT L +C S         EQK        + VQ  L  +  K+L  L  +  +++F+CGD+ GMSKDV + +S+++  +     ++ K+     +  ++    Y+EDVW
Sbjct:    1 MTDFL----IAFGSQTGQAETIAKSLKEKAELIGLTPRLHALDENEKKFNLNEEKLCAIVVSSTGDGDAPDNCARFVRRINRNSLENEYLKNLDYVLLGLGDSNYSSYQTIPRKIDKQLTALGANRLFDRAEADDQVGLELEVEPWIEKFFATLASRF-DISADKMNAITESSNLKLNQVKTEEEKKALLQKRIEDEESDDEGRGRVIGIDMLIPEHYDYPEISLLKGSQTLSNDENLRVPIAPQPFIV------SSVSNRKLPEDTKLEWQNLCKMPGVVTKPFEVLVVSAEFVTDPFSKKIKTKRMITVDFGDHAAELQYEPGDAIYFCVPNPALEVNFILKRCGVLDIADQQCELSINPKTEKIN--AQIPGHV----HKITTLRHMFTTCLDIRRAPGRPLIRVLAESTS-DPNEKRRLLELCSAQGMKDFTDFVRTPGLSLADMLFAFPNVKPPVDRLIELLPRLIPRPYSMSSYENRKARLIYSEMEF-PATDGRRHSRKGLATDWLNSLRIGDKVQVLGKEPARFRLPPLGMTKNSAGKLPLLMVGPGTGVSVFLSFLHFLRKLKQDSPSDFVDVPRVLFFGCRDSSVDAIYMSELEMFVSEGILTDLIICES---------EQKG-------ERVQDGLRKYLDKVLPFLTASTESKIFICGDAKGMSKDVWQCFSDIVASDQGIPDLEAKKK----LMDLKKSDQYIEDVW 681

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BLAST of methionine synthase reductase vs. Ensembl Celegans
Match: emb-8 (NADPH--cytochrome P450 reductase [Source:UniProtKB/TrEMBL;Acc:Q09590])

HSP 1 Score: 142.895 bits (359), Expect = 3.343e-35
Identity = 115/430 (26.74%), Postives = 190/430 (44.19%), Query Frame = 2

Query:  800 KITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLI----VRENGK--------MSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRL--LELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQT---FRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ++  +++ +S      +V  ++ +++ GD + + P N    VD +++ L                          P+H      V E+           + ++ L    D+  P+    L+ +SEYC     E+  L  L   + EG   Y + + +    ++D+L    +C+ PI  LLE+LPRL+ R YS+    S      K+ I  + T      R + GVCT ++        +   K P+++RK+     +    +   I+IGPGTG APF GFLQ  +  KN  + IG + L++GCR+ + D+I+K +L  F    +LTHL   FSR        E K         YVQ  L      + D  +N  A V++CGD+  M++DV  T   +      K +T  +A ++   M   K Y  DVW
Sbjct:  282 ELHTEHSDRSCRHIEFSVEGSRIRYEAGDHLAVFPTNDPVLVDRLINMLQFD-----------------------PDHAFRLVNVDEDASKRHPFPCPTTFRTALSHYVDICAPVKSHVLKAISEYC-TDDTEKEFLNKLSTANEEGLKEYARYIVKERRSIVDVLTDQKTCKPPIEYLLELLPRLQARYYSIA--SSPRLNEEKIAICAVVTKYSIGDRDINGVCTRYLTT-----KDAGSKSPVFVRKST--MRLPHRTTTQVIMIGPGTGFAPFRGFLQDRQFHKNAGKEIGAMHLYYGCRHPDHDYIYKDELAKFQEDEVLTHLVCAFSR------AQEHK--------IYVQDRLWETRDRIWD-AINVGAHVYICGDARNMARDVQATLQKIFREIGGKSET--EAVAYFKDMEKTKRYQADVW 661

HSP 2 Score: 66.2402 bits (160), Expect = 6.544e-11
Identity = 41/138 (29.71%), Postives = 71/138 (51.45%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKL----NFAIIIC-STTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLE 463
            +   I+YGSQTG A+ ++  L   L  Y K   + + +D+E   ++++L    +  +++C +T G+GD  DNA   +  +       LS  ++ V GLG+  Y +F      +D+ LE  GA+R +   + DD   LE
Sbjct:   71 RQVLIMYGSQTGTAEEMSGRLAKDLTRYTKKAVVVDPEDIECE-DLNRLSEVEDALLVLCIATYGEGDPTDNAVTLVEYLNAGDCD-LSGVRFAVFGLGNKTYEHFNEIGIQMDKQLEKLGAKRIFHLGLGDDDANLE 206

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Query:  800 KITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLI----VRENGK--------MSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRL--LELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQT---FRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ++  +++ +S      +V  ++ +++ GD + + P N    VD +++ L                          P+H      V E+           + ++ L    D+  P+    L+ +SEYC     E+  L  L   + EG   Y + + +    ++D+L    +C+ PI  LLE+LPRL+ R YS+    S      K+ I  + T      R + GVCT ++        +   K P+++RK+     +    +   I+IGPGTG APF GFLQ  +  KN  + IG + L++GCR+ + D+I+K +L  F    +LTHL   FSR        E K         YVQ  L      + D  +N  A V++CGD+  M++DV  T   +      K +T  +A ++   M   K Y  DVW
Sbjct:  282 ELHTEHSDRSCRHIEFSVEGSRIRYEAGDHLAVFPTNDPVLVDRLINMLQFD-----------------------PDHAFRLVNVDEDASKRHPFPCPTTFRTALSHYVDICAPVKSHVLKAISEYC-TDDTEKEFLNKLSTANEEGLKEYARYIVKERRSIVDVLTDQKTCKPPIEYLLELLPRLQARYYSIA--SSPRLNEEKIAICAVVTKYSIGDRDINGVCTRYLTT-----KDAGSKSPVFVRKST--MRLPHRTTTQVIMIGPGTGFAPFRGFLQDRQFHKNAGKEIGAMHLYYGCRHPDHDYIYKDELAKFQEDEVLTHLVCAFSR------AQEHK--------IYVQDRLWETRDRIWD-AINVGAHVYICGDARNMARDVQATLQKIFREIGGKSET--EAVAYFKDMEKTKRYQADVW 661

HSP 2 Score: 66.2402 bits (160), Expect = 6.544e-11
Identity = 41/138 (29.71%), Postives = 71/138 (51.45%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKL----NFAIIIC-STTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLE 463
            +   I+YGSQTG A+ ++  L   L  Y K   + + +D+E   ++++L    +  +++C +T G+GD  DNA   +  +       LS  ++ V GLG+  Y +F      +D+ LE  GA+R +   + DD   LE
Sbjct:   71 RQVLIMYGSQTGTAEEMSGRLAKDLTRYTKKAVVVDPEDIECE-DLNRLSEVEDALLVLCIATYGEGDPTDNAVTLVEYLNAGDCD-LSGVRFAVFGLGNKTYEHFNEIGIQMDKQLEKLGAKRIFHLGLGDDDANLE 206

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BLAST of methionine synthase reductase vs. Ensembl Celegans
Match: fre-1 (NADPH-dependent diflavin oxidoreductase 1 [Source:UniProtKB/TrEMBL;Acc:M1ZMI3])

HSP 1 Score: 129.798 bits (325), Expect = 3.709e-31
Identity = 158/629 (25.12%), Postives = 260/629 (41.34%), Query Frame = 2

Query:   74 CILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDA--VGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPAL--PSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFY----TKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLES---VSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDV 1921
             ILYGS+TG A+ IAE+L  + +       + ELD+ + S ++      + + STTG G+ P N  K  +L+  K     +L N    VLGLGD++Y  +    K + + L   GA+      +ADD   +G++    PW    ++  K++   + I  ++ ++     S         + EL G+    D D      P +  P  F   +  N    S  H            D+ LV  E+ D  +                   +K  ++PGD + + P+N E  V   +  L + E +   + +   +   +      P  L+   + K +L + L    DL+Q + K     M  Y      E+ RL EL S EG   Y     +  R T+  + D +    S  +    L E+L  ++PRA+S+    S   +    +KV+       ++R   G+C++++ ++ K  +E   KI         G     +P  P I IGPGTGVAPF     +          I    LFFGCR+E  D+ F  +    +   ++      FSRD      D +K         YVQH +  ++  +  +L +  A+VF+ G S  M K V
Sbjct:    4 AILYGSETGTAQDIAESLRREAQQRHLQARVHELDEYDVS-QLPMEKVVLFVVSTTGQGEMPPNMRKTWKLLLRKSLGADFLKNVNIGVLGLGDSSYQKYNFAGKKLYRRLVQLGAKMMCGVHLADDQHEIGIDGAFIPWKTECWKKIKEIAENLSI--YREMTAEIDTSVQITTKY-RFLELGGESGNDDDDSDEDLEPQIEIPDYFPLKVLKNRRLTSAEH----------FQDTRLVDFEISDRNR-------------------SKMGFQPGDVLMVRPYNPEETVKIAIEALGLTEEQ---LKKPLKIVKNDRFSKNPPNFLVGNFSAKTTLLTCLQRYFDLQQ-VPKRSFFEMLGYYSTNPPEKERLQELASPEGLDDYLDYANRSRRTTAEALRDFVA--TSKNLKPDYLFEILTTIRPRAFSIASAPSPFHLELLVAKVEYKSRMADKRR---GLCSTFISRL-KPGDEVFCKI-------RPGTFKFPSPEAPVICIGPGTGVAPFRSLFGHRSLFSAHFPGI----LFFGCRSEHHDYYFSDEWPELSGVAVIP----AFSRDT-----DGRK--------VYVQHKMGENAGKIKRML-DLGAQVFIAGSSGDMPKAV 560

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BLAST of methionine synthase reductase vs. Ensembl Fly
Match: Cpr (gene:FBgn0015623 transcript:FBtr0331224)

HSP 1 Score: 182.57 bits (462), Expect = 2.000e-48
Identity = 163/664 (24.55%), Postives = 288/664 (43.37%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIA-----ENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCP-MKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKRPL----TGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + YGSQTG  +  A     E +  +LK  +      +++++ +  +I   + A+   +T G+GD  DNA +F   I       LS   Y V GLG+  Y ++   +  +D+ LE  GA R +   + DD   +E     W D  +     +C    I+G             E   I  Y+ L    +  D                  IY  E  I+  H   I +   P       +  ++ + +  +K   +S     +++  +K ++  GD V + P N +S V+  L +L   + +    +     ++ +      P          + + +I         P + + L+ ++EYC   K  E  R +   S EG+  Y   +++    ++ +L    SC+ PI  + E+LPRL+PR YS+    S     + V +  +    K P      GV T++++      +E++ K+P+++RK+   F +   P  P I++GPGTG+APF GF+Q  + L++E + +G   L+FGCR    D+I++ +LE +   G L +L   FSRD                   YVQH L   + ++ +++       ++CGD+  M+ DV      +L  + +   ++ DA  +I  M  QK Y  DVW
Sbjct:   86 VFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDN-SLAVFCLATYGEGDPTDNAMEFYEWITSGDVD-LSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPA---VCDHFGIEG-----------GGEEVLIRQYRLLEQPDVQPDR-----------------IYTGE--IARLHS--IQNQRPPFDAKNPFLAPIK-VNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEK-LGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAI---------PRTHI-LKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISS--SAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQPQGSEEV-KVPVFIRKSQ--FRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGKKV--------------YVQHLLEQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKIL--STKGNMSEADAVQYIKKMEAQKRYSADVW 678

[Close]

BLAST of methionine synthase reductase vs. Ensembl Fly
Match: Cpr (gene:FBgn0015623 transcript:FBtr0331223)

HSP 1 Score: 182.57 bits (462), Expect = 2.000e-48
Identity = 163/664 (24.55%), Postives = 288/664 (43.37%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIA-----ENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCP-MKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKRPL----TGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + YGSQTG  +  A     E +  +LK  +      +++++ +  +I   + A+   +T G+GD  DNA +F   I       LS   Y V GLG+  Y ++   +  +D+ LE  GA R +   + DD   +E     W D  +     +C    I+G             E   I  Y+ L    +  D                  IY  E  I+  H   I +   P       +  ++ + +  +K   +S     +++  +K ++  GD V + P N +S V+  L +L   + +    +     ++ +      P          + + +I         P + + L+ ++EYC   K  E  R +   S EG+  Y   +++    ++ +L    SC+ PI  + E+LPRL+PR YS+    S     + V +  +    K P      GV T++++      +E++ K+P+++RK+   F +   P  P I++GPGTG+APF GF+Q  + L++E + +G   L+FGCR    D+I++ +LE +   G L +L   FSRD                   YVQH L   + ++ +++       ++CGD+  M+ DV      +L  + +   ++ DA  +I  M  QK Y  DVW
Sbjct:   86 VFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDN-SLAVFCLATYGEGDPTDNAMEFYEWITSGDVD-LSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPA---VCDHFGIEG-----------GGEEVLIRQYRLLEQPDVQPDR-----------------IYTGE--IARLHS--IQNQRPPFDAKNPFLAPIK-VNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEK-LGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAI---------PRTHI-LKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISS--SAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQPQGSEEV-KVPVFIRKSQ--FRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGKKV--------------YVQHLLEQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKIL--STKGNMSEADAVQYIKKMEAQKRYSADVW 678

[Close]

BLAST of methionine synthase reductase vs. Ensembl Fly
Match: Cpr (gene:FBgn0015623 transcript:FBtr0079250)

HSP 1 Score: 182.57 bits (462), Expect = 2.000e-48
Identity = 163/664 (24.55%), Postives = 288/664 (43.37%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIA-----ENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCP-MKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKRPL----TGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + YGSQTG  +  A     E +  +LK  +      +++++ +  +I   + A+   +T G+GD  DNA +F   I       LS   Y V GLG+  Y ++   +  +D+ LE  GA R +   + DD   +E     W D  +     +C    I+G             E   I  Y+ L    +  D                  IY  E  I+  H   I +   P       +  ++ + +  +K   +S     +++  +K ++  GD V + P N +S V+  L +L   + +    +     ++ +      P          + + +I         P + + L+ ++EYC   K  E  R +   S EG+  Y   +++    ++ +L    SC+ PI  + E+LPRL+PR YS+    S     + V +  +    K P      GV T++++      +E++ K+P+++RK+   F +   P  P I++GPGTG+APF GF+Q  + L++E + +G   L+FGCR    D+I++ +LE +   G L +L   FSRD                   YVQH L   + ++ +++       ++CGD+  M+ DV      +L  + +   ++ DA  +I  M  QK Y  DVW
Sbjct:   86 VFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDN-SLAVFCLATYGEGDPTDNAMEFYEWITSGDVD-LSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPA---VCDHFGIEG-----------GGEEVLIRQYRLLEQPDVQPDR-----------------IYTGE--IARLHS--IQNQRPPFDAKNPFLAPIK-VNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEK-LGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAI---------PRTHI-LKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISS--SAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQPQGSEEV-KVPVFIRKSQ--FRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGKKV--------------YVQHLLEQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKIL--STKGNMSEADAVQYIKKMEAQKRYSADVW 678

[Close]

BLAST of methionine synthase reductase vs. Ensembl Fly
Match: CG13667 (gene:FBgn0035890 transcript:FBtr0076611)

HSP 1 Score: 152.14 bits (383), Expect = 1.504e-38
Identity = 156/665 (23.46%), Postives = 285/665 (42.86%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDN---ASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDA--VGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWF--PSCQIPIVRLLEVLPRLKPRAYSLC-DLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVC--ENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSG-ILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +LYGSQTG A+ +AE ++ +         +   D+ + +  I +    + + +TTGDG  PDN   A +FL L +    + L   ++  LGLGD++Y  F   +K + + L++ GA       + DD    G   V   W   L+   K         G   L  ++  +  +     + KEL  D     MD              N++++ + +  +F                    ++ D  + T     + V    +        W+PGD + + P N++  V +    +     E +       +  + +    +P  L +  +  +SL     ++ DL     +  L ++++ C     E+ +LLE  S EG       +      +L++L  F   +  + + +L E++P ++PR++S+  D+ ++S     V +   +T    P  G+C++W++ +         K    L   +   T+   ++ SIP I++GPGTG+APF   +Q     +++   IGP+ +FFGCRN+  DF F      + ++  +  H    FSRD       +QK         YVQH +  +   L+ L+ + NA ++V G+S+ M K V E +  +L G         DAD ++  M  Q+ Y E+ W
Sbjct:    5 VLYGSQTGTAQDVAEQIWRESHQLGFQGPVLPFDEYDMTKLIEE-RLVVFVVATTGDGVEPDNMKLAWRFL-LKRSLPAQSLQGMQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVCPVGLCDDQHDYGHLGVSLSWTKDLWTALK---------GISGLDESKLSNSHQTTVKWSVKELPKDSQIAPMD--------------NLLWSQKQTAHSF--------------------KILDNQRTTAVDHFQDVRFLRLQCQTEDLSWEPGDVLDVQPQNSDEAVQTFFDLIR----EHSLNFDESTIVEVSSAHQDMP--LPIAYSNPLSLLQAAKFVWDLSAKPRQRFLEVLAQNC-CDEMEKEKLLEFSSAEGIDDLVAYVNRPRRNLLEVLEDFRHATSSLTLQQLFEMMPLIQPRSFSIASDVSALSLDL-LVAVVEYKTIMHTPRLGLCSNWLKTL---------KSGTELSGVVKRGTMVWPKDLSIPLIMVGPGTGIAPFRSIIQNRLYAQSKGATIGPLVVFFGCRNKAADFHFGNDFSTWTDAKQVEAH--TAFSRDQ------DQK--------VYVQHLIAKNGAHLARLIKDLNAYIYVAGNSNNMPKSVKEAFIEILDG---------DAD-YVELMIKQRRYQEETW 581

[Close]

BLAST of methionine synthase reductase vs. Ensembl Fly
Match: CG13667 (gene:FBgn0035890 transcript:FBtr0076610)

HSP 1 Score: 152.14 bits (383), Expect = 1.504e-38
Identity = 156/665 (23.46%), Postives = 285/665 (42.86%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDN---ASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDA--VGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWF--PSCQIPIVRLLEVLPRLKPRAYSLC-DLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVC--ENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSG-ILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +LYGSQTG A+ +AE ++ +         +   D+ + +  I +    + + +TTGDG  PDN   A +FL L +    + L   ++  LGLGD++Y  F   +K + + L++ GA       + DD    G   V   W   L+   K         G   L  ++  +  +     + KEL  D     MD              N++++ + +  +F                    ++ D  + T     + V    +        W+PGD + + P N++  V +    +     E +       +  + +    +P  L +  +  +SL     ++ DL     +  L ++++ C     E+ +LLE  S EG       +      +L++L  F   +  + + +L E++P ++PR++S+  D+ ++S     V +   +T    P  G+C++W++ +         K    L   +   T+   ++ SIP I++GPGTG+APF   +Q     +++   IGP+ +FFGCRN+  DF F      + ++  +  H    FSRD       +QK         YVQH +  +   L+ L+ + NA ++V G+S+ M K V E +  +L G         DAD ++  M  Q+ Y E+ W
Sbjct:    5 VLYGSQTGTAQDVAEQIWRESHQLGFQGPVLPFDEYDMTKLIEE-RLVVFVVATTGDGVEPDNMKLAWRFL-LKRSLPAQSLQGMQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVCPVGLCDDQHDYGHLGVSLSWTKDLWTALK---------GISGLDESKLSNSHQTTVKWSVKELPKDSQIAPMD--------------NLLWSQKQTAHSF--------------------KILDNQRTTAVDHFQDVRFLRLQCQTEDLSWEPGDVLDVQPQNSDEAVQTFFDLIR----EHSLNFDESTIVEVSSAHQDMP--LPIAYSNPLSLLQAAKFVWDLSAKPRQRFLEVLAQNC-CDEMEKEKLLEFSSAEGIDDLVAYVNRPRRNLLEVLEDFRHATSSLTLQQLFEMMPLIQPRSFSIASDVSALSLDL-LVAVVEYKTIMHTPRLGLCSNWLKTL---------KSGTELSGVVKRGTMVWPKDLSIPLIMVGPGTGIAPFRSIIQNRLYAQSKGATIGPLVVFFGCRNKAADFHFGNDFSTWTDAKQVEAH--TAFSRDQ------DQK--------VYVQHLIAKNGAHLARLIKDLNAYIYVAGNSNNMPKSVKEAFIEILDG---------DAD-YVELMIKQRRYQEETW 581

[Close]

BLAST of methionine synthase reductase vs. Ensembl Zebrafish
Match: mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:ZFIN;Acc:ZDB-GENE-101115-3])

HSP 1 Score: 370.933 bits (951), Expect = 1.153e-117
Identity = 248/723 (34.30%), Postives = 387/723 (53.53%), Query Frame = 2

Query:   53 CDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPI-------------------DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKN----------------LTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWK-WKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLE-----SVSFAFSKVDIA--PIQTFRKRPLTGVCTSWM----EKMAKFHNEQIW----------KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQ--NIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            C+      ILYGSQ GQA+SIAE +  +  ++    +I  L   +K     +    + + STTGDGD PD A KF+R IK       +LS+ +Y +LGLGDTNY+NFCN  KTID  L+  GA+ FY +  ADD  GLE+VV+PW++GL++  K   S +                     D  +NL +  ++ K+        K +  D +A ++   +                L VPALP  +L I+    +++            +P  D    +  +    ++T   A+K+     +++   + + ++PGD+  IL  N +SEV+ +L +L + + +KNC V++ LL+N   + AKVP H  + +NG  SL+ IL W  ++R    K  LR + ++    ++E+RRLLELCS++G + Y   +R++S+ VLDLL  FPSC  P+  L E LP+L+PRAYS           V   F+ V+    P    RK    G+CT W+      + + H   +           K+ +  R + + F +  +P +P +++GPGTGVAPFIGFLQ  EK +  NQ    G +WLFFGCR++++DF+F+++LE F ++G L+HL VCFSRD P    D  +   +P    YVQH L+ H+K L+ +L+     ++VCGD+  M+KDV +T   + +GN  ++  K DA   + G+R  K YL+D+W
Sbjct:    3 CEAAAHFLILYGSQRGQAQSIAEEICQQAAEHGFTADISCLSKHDKYNLDSESRPVVFVVSTTGDGDPPDTALKFVRKIKNKSLPHDHLSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHADDGTGLEVVVDPWIEGLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLKLSEVDSPKGKTVTSDSIATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEE--------TVLPDKDGYFEV-PISKAVQLTQDDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVEELLLKLDL-QMQKNCTVQVNLLKNTSKKAAKVPLH--IPQNG--SLQFILTWCLEIRSTPKKAFLRALVDFT-QNASEKRRLLELCSKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSLLFEHLPKLQPRAYSAASSSLQHPGKVHLVFNVVEFPARPEHPARK----GLCTGWLVDHVSSILEPHGTALASERPGTSALPKVHVRARPS-STFHLPSDPCVPVVMVGPGTGVAPFIGFLQQREKEREANQEATFGEMWLFFGCRHKDKDFLFREELEKFVHNGTLSHLIVCFSRDEP----DAAETVNRP---TYVQHNLILHAKNLAKILLEDKGCLYVCGDAKNMAKDVNDTLLEI-IGNELQLD-KLDAMKIVAGLREDKRYLQDIW 696

[Close]

BLAST of methionine synthase reductase vs. Ensembl Zebrafish
Match: mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:ZFIN;Acc:ZDB-GENE-101115-3])

HSP 1 Score: 371.318 bits (952), Expect = 1.429e-117
Identity = 249/731 (34.06%), Postives = 390/731 (53.35%), Query Frame = 2

Query:   29 FVYIMHLLCDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPI-------------------DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKN----------------LTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWK-WKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLE-----SVSFAFSKVDIA--PIQTFRKRPLTGVCTSWM----EKMAKFHNEQIW----------KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQ--NIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            F    ++ C+      ILYGSQ GQA+SIAE +  +  ++    +I  L   +K     +    + + STTGDGD PD A KF+R IK       +LS+ +Y +LGLGDTNY+NFCN  KTID  L+  GA+ FY +  ADD  GLE+VV+PW++GL++  K   S +                     D  +NL +  ++ K+        K +  D +A ++   +                L VPALP  +L I+    +++            +P  D    +  +    ++T   A+K+     +++   + + ++PGD+  IL  N +SEV+ +L +L + + +KNC V++ LL+N   + AKVP H  + +NG  SL+ IL W  ++R    K  LR + ++    ++E+RRLLELCS++G + Y   +R++S+ VLDLL  FPSC  P+  L E LP+L+PRAYS           V   F+ V+    P    RK    G+CT W+      + + H   +           K+ +  R + + F +  +P +P +++GPGTGVAPFIGFLQ  EK +  NQ    G +WLFFGCR++++DF+F+++LE F ++G L+HL VCFSRD P    D  +   +P    YVQH L+ H+K L+ +L+     ++VCGD+  M+KDV +T   + +GN  ++  K DA   + G+R  K YL+D+W
Sbjct:    9 FSSFYNMPCEAAAHFLILYGSQRGQAQSIAEEICQQAAEHGFTADISCLSKHDKYNLDSESRPVVFVVSTTGDGDPPDTALKFVRKIKNKSLPHDHLSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHADDGTGLEVVVDPWIEGLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLKLSEVDSPKGKTVTSDSIATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEE--------TVLPDKDGYFEV-PISKAVQLTQDDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVEELLLKLDL-QMQKNCTVQVNLLKNTSKKAAKVPLH--IPQNG--SLQFILTWCLEIRSTPKKAFLRALVDFT-QNASEKRRLLELCSKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSLLFEHLPKLQPRAYSAASSSLQHPGKVHLVFNVVEFPARPEHPARK----GLCTGWLVDHVSSILEPHGTALASERPGTSALPKVHVRARPS-STFHLPSDPCVPVVMVGPGTGVAPFIGFLQQREKEREANQEATFGEMWLFFGCRHKDKDFLFREELEKFVHNGTLSHLIVCFSRDEP----DAAETVNRP---TYVQHNLILHAKNLAKILLEDKGCLYVCGDAKNMAKDVNDTLLEI-IGNELQLD-KLDAMKIVAGLREDKRYLQDIW 710

[Close]

BLAST of methionine synthase reductase vs. Ensembl Zebrafish
Match: mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:ZFIN;Acc:ZDB-GENE-101115-3])

HSP 1 Score: 359.762 bits (922), Expect = 1.989e-113
Identity = 242/715 (33.85%), Postives = 383/715 (53.57%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPI-------------------DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKN----------------LTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWK-WKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLE-----SVSFAFSKVDIA--PIQTFRKRPLTGVCTSWM----EKMAKFHNEQIW----------KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQ--NIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ++  S+ GQA+SIAE +  +  ++    +I  L   +K     +    + + STTGDGD PD A KF+R IK       +LS+ +Y +LGLGDTNY+NFCN  KTID  L+  GA+ FY +  ADD  GLE+VV+PW++GL++  K   S +                     D  +NL +  ++ K+        K +  D +A ++   +                L VPALP  +L I+    +++            +P  D    +  +    ++T   A+K+     +++   + + ++PGD+  IL  N +SEV+ +L +L + + +KNC V++ LL+N   + AKVP H  + +NG  SL+ IL W  ++R    K  LR + ++    ++E+RRLLELCS++G + Y   +R++S+ VLDLL  FPSC  P+  L E LP+L+PRAYS           V   F+ V+    P    RK    G+CT W+      + + H   +           K+ +  R + + F +  +P +P +++GPGTGVAPFIGFLQ  EK +  NQ    G +WLFFGCR++++DF+F+++LE F ++G L+HL VCFSRD P    D  +   +P    YVQH L+ H+K L+ +L+     ++VCGD+  M+KDV +T   + +GN  ++  K DA   + G+R  K YL+D+W
Sbjct:    9 VICKSKRGQAQSIAEEICQQAAEHGFTADISCLSKHDKYNLDSESRPVVFVVSTTGDGDPPDTALKFVRKIKNKSLPHDHLSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHADDGTGLEVVVDPWIEGLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLKLSEVDSPKGKTVTSDSIATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEE--------TVLPDKDGYFEV-PISKAVQLTQDDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVEELLLKLDL-QMQKNCTVQVNLLKNTSKKAAKVPLH--IPQNG--SLQFILTWCLEIRSTPKKAFLRALVDFT-QNASEKRRLLELCSKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSLLFEHLPKLQPRAYSAASSSLQHPGKVHLVFNVVEFPARPEHPARK----GLCTGWLVDHVSSILEPHGTALASERPGTSALPKVHVRARPS-STFHLPSDPCVPVVMVGPGTGVAPFIGFLQQREKEREANQEATFGEMWLFFGCRHKDKDFLFREELEKFVHNGTLSHLIVCFSRDEP----DAAETVNRP---TYVQHNLILHAKNLAKILLEDKGCLYVCGDAKNMAKDVNDTLLEI-IGNELQLD-KLDAMKIVAGLREDKRYLQDIW 694

[Close]

BLAST of methionine synthase reductase vs. Ensembl Zebrafish
Match: mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:ZFIN;Acc:ZDB-GENE-101115-3])

HSP 1 Score: 206.068 bits (523), Expect = 2.020e-58
Identity = 148/453 (32.67%), Postives = 235/453 (51.88%), Query Frame = 2

Query:   53 CDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPI-------------------DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKN----------------LTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWK-WKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLL 1297
            C+      ILYGSQ GQA+SIAE +  +  ++    +I  L   +K     +    + + STTGDGD PD A KF+R IK       +LS+ +Y +LGLGDTNY+NFCN  KTID  L+  GA+ FY +  ADD  GLE+VV+PW++GL++  K   S +                     D  +NL +  ++ K+        K +  D +A ++   +                L VPALP  +L I+    +++            +P  D    +  +    ++T   A+K+     +++   + + ++PGD+  IL  N +SEV+ +L +L + + +KNC V++ LL+N   + AKVP H  + +NG  SL+ IL W  ++R    K  LR + ++    ++E+RRLLELCS++G + Y   +R++S+ VLDLL  FPSC  P+  L 
Sbjct:    3 CEAAAHFLILYGSQRGQAQSIAEEICQQAAEHGFTADISCLSKHDKYNLDSESRPVVFVVSTTGDGDPPDTALKFVRKIKNKSLPHDHLSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHADDGTGLEVVVDPWIEGLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLKLSEVDSPKGKTVTSDSIATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEE--------TVLPDKDGYFEV-PISKAVQLTQDDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVEELLLKLDL-QMQKNCTVQVNLLKNTSKKAAKVPLH--IPQNG--SLQFILTWCLEIRSTPKKAFLRALVDFT-QNASEKRRLLELCSKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSLLF 440

[Close]

BLAST of methionine synthase reductase vs. Ensembl Zebrafish
Match: porb (P450 (cytochrome) oxidoreductase b [Source:ZFIN;Acc:ZDB-GENE-030131-5767])

HSP 1 Score: 200.675 bits (509), Expect = 1.295e-54
Identity = 173/668 (25.90%), Postives = 291/668 (43.56%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDY-IKHINI----FELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV---SFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVL--LGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            K   + YGSQTG A+  +  L      Y +K +      ++L ++ +  EI   + AI   +T G+GD  DNA  F   ++     + S  KYTV  LG+  Y ++    K +D+ LE  GA+R +   M DD   LE     W +  +     +C    ++     S   +        +   K   G+       G+  +      PF        DS + F  P+                    + +  NK   + +    +++  +K +++ GD V + P N  + V+ I   L+V   + + V+ L  L+   N++   P     R        ++  +L     P + V   +       K  E  R +   S EG++ Y   + ++   ++ +L   PS + PI  L E+LPRL+ R YS+     V   S     V +   QT   R   GV T+W++      N     +P+Y+RK+   F +    + P I+IGPGTG+APFIGF+Q    LK + + +G   L+FGCR++  DF+++++L  F  +G+LT L V FSRD                   YVQH L ++ + +  L+   NA +++CGD+  M++DV   +  +   LG   + Q    A  +I  +  +  Y +DVW
Sbjct:   72 KNIVVFYGSQTGTAEEFSNRLAKDAHRYGMKGMAADPEEYDLSELSRMGEIDN-SLAIFCLATYGEGDPTDNAQDFYDWLQEADADF-SGLKYTVFALGNKTYEHYNAMGKYVDKRLEELGAQRIFDLGMGDDDGNLEEDFVSWREQFWPA---VCEHFGVEATGEESSIRQYELKVHTDLNMNKVYTGEL------GRLKSFENQKPPF--------DSKNPFLAPVT-------------------VNRKLNKGGERHLMHLELDITGSKIRYESGDHVAVYPINDTAMVNKIGELLAV---DLDTVISLNNLDEESNKKHPFPCPTTYR-------TALTHYLDITNSPRTNVLYELAQYASDPKDQENMRKMASSSAEGKAQYQSWVLDSCRNIVAILEDLPSLRPPIDHLCELLPRLQARYYSISSSSKVHPNSIHICAV-VVEYQTKTGRVNKGVATNWLKNKMPTDNGHKATVPMYIRKSQ--FRLPFKSTNPIIMIGPGTGIAPFIGFIQERGWLKEQGKEVGETVLYFGCRHKNEDFLYQEELAQFEKTGVLTTLNVAFSRDQAEKV--------------YVQHHLKNNKEAVWKLVHTDNAHIYICGDARNMARDVQTAFYEIAEELGGMSRPQ----AVDYIKKLMTKGRYSQDVW 670

[Close]

BLAST of methionine synthase reductase vs. Ensembl Xenopus
Match: MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:NCBI gene;Acc:733716])

HSP 1 Score: 368.237 bits (944), Expect = 1.368e-116
Identity = 241/706 (34.14%), Postives = 384/706 (54.39%), Query Frame = 2

Query:   68 MTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLY----------------EIAKDMCSEIPI--DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMD---------------GKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYS-----LCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKM-------AKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            M  +LYG+Q GQ+K+I+E +  + + +    +I+ L D +K     + +  +I+ STTG GD PD A +FL+ I  K +   Y +N KY VL LGD+ Y+ FCN  K ID  L+  GA+ FY +  ADD VGLE+VV+PW++GL+                +  K+M +E P   +  +NL +  +   +E   +  Y   L ++   + +                 NL VP LPSP+L++     +  S       T + +   + ++    +    ++T+  A+K+V    +++ N   +++PGDS  I+  N   EV+ +L +L++ E +++C V L +    + + A VP ++        SL+ I  W  ++R    K  +R + E+    +AE+RRL ELCS++G S Y   +R+ S+ +LDLLN FPSC  P+  L+E LP+L+ R YS     L     V   F+ V++ P    R  P  GVCT W+ ++       A+   +   KI I+ R + + F +  +PS+P +++GPGTG+APFIGFLQ+ EKLK +N+    G  WLFFGCR+ E +++F+++L HF +SG+LTHL VCFSRD P N+G        P   KYVQ  L   S  ++ +L  +N  ++VCGD+  M+KDV +  +N+L    E    K +A + +  +R QK YL+DVW
Sbjct:    1 MFLLLYGTQQGQSKAISEEIGQQAEHHGFTADIYSLKDFKKFNLETERDPVVIVISTTGTGDPPDAAIRFLKEIQNKEHPVDYFANLKYAVLALGDSEYTYFCNGGKIIDWRLQELGAKHFYETGYADDCVGLELVVDPWIEGLWTALHSEFIPRTEKKNTDHMKNMSTEKPATDEVPENLELRIQAINLEHSVLPKYS--LAENTGSESNRVIKPSLLHSGSLLSQSNLNVPVLPSPYLDVCVLESEGQS-------TDLSLLYPEEKIFNISIIQAKELTSADAVKTVLMLELDISNTSAEFQPGDSFSIICPNPHEEVEMLLEKLTLAE-KRDCQVHLGVKLGTKKKGASVPGYI----PEGCSLQFIFTWCLEIRAVPKKAMIRALVEHT-SNAAEKRRLQELCSKQGGSDYNHFIRDNSISILDLLNVFPSCSPPLNLLIEHLPKLQARPYSAASSPLYHPGKVHIVFTVVEL-PTCPDRPAPRKGVCTGWLAELVSHMYDTAELKKDFPPKISIFARPSTS-FHLPRDPSVPILMVGPGTGIAPFIGFLQHREKLKEQNKERIFGDTWLFFGCRSHENEYLFRQELRHFTDSGVLTHLKVCFSRDPPINAG-----VVSP---KYVQDFLKICSSDIAKVLTKENGSIYVCGDAKNMAKDVNDALANILC--MELNMDKLEAINTLAVLRDQKCYLQDVW 679

[Close]

BLAST of methionine synthase reductase vs. Ensembl Xenopus
Match: MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:NCBI gene;Acc:733716])

HSP 1 Score: 367.466 bits (942), Expect = 3.292e-116
Identity = 240/703 (34.14%), Postives = 383/703 (54.48%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLY----------------EIAKDMCSEIPI--DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMD---------------GKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYS-----LCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKM-------AKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +LYG+Q GQ+K+I+E +  + + +    +I+ L D +K     + +  +I+ STTG GD PD A +FL+ I  K +   Y +N KY VL LGD+ Y+ FCN  K ID  L+  GA+ FY +  ADD VGLE+VV+PW++GL+                +  K+M +E P   +  +NL +  +   +E   +  Y   L ++   + +                 NL VP LPSP+L++     +  S       T + +   + ++    +    ++T+  A+K+V    +++ N   +++PGDS  I+  N   EV+ +L +L++ E +++C V L +    + + A VP ++        SL+ I  W  ++R    K  +R + E+    +AE+RRL ELCS++G S Y   +R+ S+ +LDLLN FPSC  P+  L+E LP+L+ R YS     L     V   F+ V++ P    R  P  GVCT W+ ++       A+   +   KI I+ R + + F +  +PS+P +++GPGTG+APFIGFLQ+ EKLK +N+    G  WLFFGCR+ E +++F+++L HF +SG+LTHL VCFSRD P N+G        P   KYVQ  L   S  ++ +L  +N  ++VCGD+  M+KDV +  +N+L    E    K +A + +  +R QK YL+DVW
Sbjct:   11 LLYGTQQGQSKAISEEIGQQAEHHGFTADIYSLKDFKKFNLETERDPVVIVISTTGTGDPPDAAIRFLKEIQNKEHPVDYFANLKYAVLALGDSEYTYFCNGGKIIDWRLQELGAKHFYETGYADDCVGLELVVDPWIEGLWTALHSEFIPRTEKKNTDHMKNMSTEKPATDEVPENLELRIQAINLEHSVLPKYS--LAENTGSESNRVIKPSLLHSGSLLSQSNLNVPVLPSPYLDVCVLESEGQS-------TDLSLLYPEEKIFNISIIQAKELTSADAVKTVLMLELDISNTSAEFQPGDSFSIICPNPHEEVEMLLEKLTLAE-KRDCQVHLGVKLGTKKKGASVPGYI----PEGCSLQFIFTWCLEIRAVPKKAMIRALVEHT-SNAAEKRRLQELCSKQGGSDYNHFIRDNSISILDLLNVFPSCSPPLNLLIEHLPKLQARPYSAASSPLYHPGKVHIVFTVVEL-PTCPDRPAPRKGVCTGWLAELVSHMYDTAELKKDFPPKISIFARPSTS-FHLPRDPSVPILMVGPGTGIAPFIGFLQHREKLKEQNKERIFGDTWLFFGCRSHENEYLFRQELRHFTDSGVLTHLKVCFSRDPPINAG-----VVSP---KYVQDFLKICSSDIAKVLTKENGSIYVCGDAKNMAKDVNDALANILC--MELNMDKLEAINTLAVLRDQKCYLQDVW 686

[Close]

BLAST of methionine synthase reductase vs. Ensembl Xenopus
Match: MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:NCBI gene;Acc:733716])

HSP 1 Score: 349.747 bits (896), Expect = 7.758e-110
Identity = 239/708 (33.76%), Postives = 371/708 (52.40%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLY----------------EIAKDMCSEIPI--DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMD---------------GKNLTVPALPSPFLNI-IYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYS-----LCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKM-------AKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            K   +LYG+Q GQ+K+I+E +  + + +    +I+ L D +K     + +  +I+ STTG GD PD A +FL+ I  K +   Y +N KY VL LGD+ Y+ FCN  K ID  L+  GA+ FY +  ADD VGLE+VV+PW++GL+                +  K+M +E P   +  +NL +  +   +E   +  Y   L ++   + +                 NL VP LPSP+L++ +  +E  I+                                     S H+      N   +++PGDS  I+  N   EV+ +L +L++ E +++C V L +    + + A VP ++        SL+ I  W  ++R    K  +R + E+    +AE+RRL ELCS++G S Y   +R+ S+ +LDLLN FPSC  P+  L+E LP+L+ R YS     L     V   F+ V++ P    R  P  GVCT W+ ++       A+   +   KI I+ R + + F +  +PS+P +++GPGTG+APFIGFLQ+ EKLK +N+    G  WLFFGCR+ E +++F+++L HF +SG+LTHL VCFSRD P N+G        P   KYVQ  L   S  ++ +L  +N  ++VCGD+  M+KDV +  +N+L    E    K +A + +  +R QK YL+DVW
Sbjct:    7 KRFLLLYGTQQGQSKAISEEIGQQAEHHGFTADIYSLKDFKKFNLETERDPVVIVISTTGTGDPPDAAIRFLKEIQNKEHPVDYFANLKYAVLALGDSEYTYFCNGGKIIDWRLQELGAKHFYETGYADDCVGLELVVDPWIEGLWTALHSEFIPRTEKKNTDHMKNMSTEKPATDEVPENLELRIQAINLEHSVLPKYS--LAENTGSESNRVIKPSLLHSGSLLSQSNLNVPVLPSPYLDVCVLESEGQIT---------------------------------LVFFSFHK------NTSAEFQPGDSFSIICPNPHEEVEMLLEKLTLAE-KRDCQVHLGVKLGTKKKGASVPGYI----PEGCSLQFIFTWCLEIRAVPKKAMIRALVEHT-SNAAEKRRLQELCSKQGGSDYNHFIRDNSISILDLLNVFPSCSPPLNLLIEHLPKLQARPYSAASSPLYHPGKVHIVFTVVEL-PTCPDRPAPRKGVCTGWLAELVSHMYDTAELKKDFPPKISIFARPSTS-FHLPRDPSVPILMVGPGTGIAPFIGFLQHREKLKEQNKERIFGDTWLFFGCRSHENEYLFRQELRHFTDSGVLTHLKVCFSRDPPINAG-----VVSP---KYVQDFLKICSSDIAKVLTKENGSIYVCGDAKNMAKDVNDALANILC--MELNMDKLEAINTLAVLRDQKCYLQDVW 655

[Close]

BLAST of methionine synthase reductase vs. Ensembl Xenopus
Match: MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:NCBI gene;Acc:733716])

HSP 1 Score: 339.732 bits (870), Expect = 1.057e-105
Identity = 233/702 (33.19%), Postives = 378/702 (53.85%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLY----------------EIAKDMCSEIPI--DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMD---------------GKNLTVPALPSPFLNI-IYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLL--EVLPRLKPRAYS-LCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKM-------AKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +LYG+Q GQ+K+I+E +  + + +    +I+ L D +K     + +  +I+ STTG GD PD A +FL+ I  K +   Y +N KY VL LGD+ Y+ FCN  K ID  L+  GA+ FY +  ADD VGLE+VV+PW++GL+                +  K+M +E P   +  +NL +  +   +E   +  Y   L ++   + +                 NL VP LPSP+L++ +  +E  +          + +   + ++    +    ++T+  A+K+V    +++  +  +++PGDS  I+  N   EV+ +L +L++ E +++C V L +    + + A VP ++        SL+ I  W  ++R    K  +R + E+    +AE+RRL ELCS++G S Y   +R+ S+ +LDLLN FPSC  P+  L+    L       +S L     V   F+ V++ P    R  P  GVCT W+ ++       A+   +   KI I+ R + + F +  +PS+P +++GPGTG+APFIGFLQ+ EKLK +N+    G  WLFFGCR+ E +++F+++L HF +SG+LTHL VCFSRD P N+G        P   KYVQ  L   S  ++ +L  +N  ++VCGD+  M+KDV +  +N+L    E    K +A + +  +R QK YL+DVW
Sbjct:   11 LLYGTQQGQSKAISEEIGQQAEHHGFTADIYSLKDFKKFNLETERDPVVIVISTTGTGDPPDAAIRFLKEIQNKEHPVDYFANLKYAVLALGDSEYTYFCNGGKIIDWRLQELGAKHFYETGYADDCVGLELVVDPWIEGLWTALHSEFIPRTEKKNTDHMKNMSTEKPATDEVPENLELRIQAINLEHSVLPKYS--LAENTGSESNRVIKPSLLHSGSLLSQSNLNVPVLPSPYLDVCVLESEGQVD---------LSLLYPEEKIFNISIIQAKELTSADAVKTVLMLELDI--SVTEFQPGDSFSIICPNPHEEVEMLLEKLTLAE-KRDCQVHLGVKLGTKKKGASVPGYI----PEGCSLQFIFTWCLEIRAVPKKAMIRALVEHTS-NAAEKRRLQELCSKQGGSDYNHFIRDNSISILDLLNVFPSCSPPLNLLIGKHALNAAMFVCFSPLYHPGKVHIVFTVVEL-PTCPDRPAPRKGVCTGWLAELVSHMYDTAELKKDFPPKISIFARPSTS-FHLPRDPSVPILMVGPGTGIAPFIGFLQHREKLKEQNKERIFGDTWLFFGCRSHENEYLFRQELRHFTDSGVLTHLKVCFSRDPPINAG-----VVSP---KYVQDFLKICSSDIAKVLTKENGSIYVCGDAKNMAKDVNDALANILC--MELNMDKLEAINTLAVLRDQKCYLQDVW 681

[Close]

BLAST of methionine synthase reductase vs. Ensembl Xenopus
Match: MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:NCBI gene;Acc:733716])

HSP 1 Score: 271.937 bits (694), Expect = 8.050e-82
Identity = 170/478 (35.56%), Postives = 269/478 (56.28%), Query Frame = 2

Query:  647 NLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYS-----LCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKM-------AKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            NL VP LPSP+L++     +  S       T + +   + ++    +    ++T+  A+K+V    +++ N   +++PGDS  I+  N   EV+ +L +L++ E +++C V L +    + + A VP ++        SL+ I  W  ++R    K  +R + E+    +AE+RRL ELCS++G S Y   +R+ S+ +LDLLN FPSC  P+  L+E LP+L+ R YS     L     V   F+ V++ P    R  P  GVCT W+ ++       A+   +   KI I+ R +   F +  +PS+P +++GPGTG+APFIGFLQ+ EKLK +N+    G  WLFFGCR+ E +++F+++L HF +SG+LTHL VCFSRD P N+G        P   KYVQ  L   S  ++ +L  +N  ++VCGD+  M+KDV +  +N+L    E    K +A + +  +R QK YL+DVW
Sbjct:   75 NLNVPVLPSPYLDVCVLESEGQS-------TDLSLLYPEEKIFNISIIQAKELTSADAVKTVLMLELDISNTSAEFQPGDSFSIICPNPHEEVEMLLEKLTLAE-KRDCQVHLGVKLGTKKKGASVPGYI----PEGCSLQFIFTWCLEIRAVPKKAMIRALVEHT-SNAAEKRRLQELCSKQGGSDYNHFIRDNSISILDLLNVFPSCSPPLNLLIEHLPKLQARPYSAASSPLYHPGKVHIVFTVVEL-PTCPDRPAPRKGVCTGWLAELVSHMYDTAELKKDFPPKISIFARPS-TSFHLPRDPSVPILMVGPGTGIAPFIGFLQHREKLKEQNKERIFGDTWLFFGCRSHENEYLFRQELRHFTDSGVLTHLKVCFSRDPPINAG-----VVSP---KYVQDFLKICSSDIAKVLTKENGSIYVCGDAKNMAKDVNDALANILC--MELNMDKLEAINTLAVLRDQKCYLQDVW 527

[Close]

BLAST of methionine synthase reductase vs. Ensembl Mouse
Match: Mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:MGI Symbol;Acc:MGI:1891037])

HSP 1 Score: 345.895 bits (886), Expect = 4.527e-108
Identity = 235/726 (32.37%), Postives = 379/726 (52.20%), Query Frame = 2

Query:   62 LKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYE-IAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELL--------------GD---------------------------HLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAY-----SLCDLESVSFAFSKVDIAPIQT---FRKRPLTGVCTSWMEKM-AKF------------HNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ++   +LY +Q GQAK+IAE +  +   +    ++  + + EK     +    +++ STTG GD PD A KF++ I  K     Y ++ +Y +LGLGD+ Y+ FCN  K ID+ L+  GA+RFY +  ADD VGLE+VVEPW+DGL+  + K   S   + G +N+S T   +           ELL              G+                           H    +   +L++PA+P  +L +  + ++S+            +PS D    +  +    ++T   A+KS     +++   ++  +PGDS  +   N++ EV+ +L RL + +   + V+     +  +   A +P H+     G+ SL+ IL W  ++R    K  LR ++E+    + E+RRL ELCS++G + Y + +R+ S+ +LDLL  FPSCQ P+  LLE LP+L+PR Y     SL   + + F F+ V+  P  T    RK    GVCT W+  + A F             +    +I I  R   N F + E+PS P I++GPGTGVAPF+GFLQ+ EKL+ ++ +   G +WLFFGCR+++RD++F+++L HF  +G+LTHL V FSRD   + G+E          KYVQ  L  HS+ ++  L+ +N  V+VCGD+  M+KDV +T   ++  ++E    K +A   +  ++ +K YL+D+W
Sbjct:    1 MRRFLLLYATQRGQAKAIAEEISEQAVSHGFSADLHCISESEKYDLKTETGPLVMVVSTTGTGDPPDTARKFVKEIHNKTLPTDYFAHLQYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQRFYDTGHADDCVGLELVVEPWIDGLWAALTKHFKS---LGGQENMSDTLSRASDAPLSTAMKPELLHIQSQVELLRLEDMGERDSELREQNETNRGQQGRIEDFDSSLVHSVPPLSQSSLSIPAVPPEYLEV--HLQESLGQEE----NQASVPSGDPSFQV-PISKAIRLTTNDAVKSTLLLELDISKIEFSHQPGDSFNVTCPNSDREVEELLQRLQLADKRAHRVILKIKTDTKKKGAA-LPAHV---PEGR-SLQFILTWCLEIRAVPKKAFLRALAEHT-SSATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLSLLLEHLPKLQPRPYSCASSSLRHPDKLHFVFNIVEFPPSTTAASLRK----GVCTGWLATLVAPFLQPNTDVSNVDSGDALAPEIRISPRAT-NAFHLPEDPSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGKFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPD-GEEAP-------AKYVQDNLQRHSQQVARTLLQENGYVYVCGDAKNMAKDVNDTLIGII--SNEAGVDKLEAMKTLATLKQEKRYLQDIW 695

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Query:   62 LKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYE-IAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELL--------------GD---------------------------HLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAY-----SLCDLESVSFAFSKVDIAPIQT---FRKRPLTGVCTSWMEKM-AKF------------HNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ++   +LY +Q GQAK+IAE +  +   +    ++  + + EK     +    +++ STTG GD PD A KF++ I  K     Y ++ +Y +LGLGD+ Y+ FCN  K ID+ L+  GA+RFY +  ADD VGLE+VVEPW+DGL+  + K   S   + G +N+S T   +           ELL              G+                           H    +   +L++PA+P  +L +  + ++S+            +PS D    +  +    ++T   A+KS     +++   ++  +PGDS  +   N++ EV+ +L RL + +   + V+     +  +   A +P H+     G+ SL+ IL W  ++R    K  LR ++E+    + E+RRL ELCS++G + Y + +R+ S+ +LDLL  FPSCQ P+  LLE LP+L+PR Y     SL   + + F F+ V+  P  T    RK    GVCT W+  + A F             +    +I I  R   N F + E+PS P I++GPGTGVAPF+GFLQ+ EKL+ ++ +   G +WLFFGCR+++RD++F+++L HF  +G+LTHL V FSRD   + G+E          KYVQ  L  HS+ ++  L+ +N  V+VCGD+  M+KDV +T   ++  ++E    K +A   +  ++ +K YL+D+W
Sbjct:    1 MRRFLLLYATQRGQAKAIAEEISEQAVSHGFSADLHCISESEKYDLKTETGPLVMVVSTTGTGDPPDTARKFVKEIHNKTLPTDYFAHLQYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQRFYDTGHADDCVGLELVVEPWIDGLWAALTKHFKS---LGGQENMSDTLSRASDAPLSTAMKPELLHIQSQVELLRLEDMGERDSELREQNETNRGQQGRIEDFDSSLVHSVPPLSQSSLSIPAVPPEYLEV--HLQESLGQEE----NQASVPSGDPSFQV-PISKAIRLTTNDAVKSTLLLELDISKIEFSHQPGDSFNVTCPNSDREVEELLQRLQLADKRAHRVILKIKTDTKKKGAA-LPAHV---PEGR-SLQFILTWCLEIRAVPKKAFLRALAEHT-SSATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLSLLLEHLPKLQPRPYSCASSSLRHPDKLHFVFNIVEFPPSTTAASLRK----GVCTGWLATLVAPFLQPNTDVSNVDSGDALAPEIRISPRAT-NAFHLPEDPSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGKFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPD-GEEAP-------AKYVQDNLQRHSQQVARTLLQENGYVYVCGDAKNMAKDVNDTLIGII--SNEAGVDKLEAMKTLATLKQEKRYLQDIW 695

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BLAST of methionine synthase reductase vs. Ensembl Mouse
Match: Por (P450 (cytochrome) oxidoreductase [Source:MGI Symbol;Acc:MGI:97744])

HSP 1 Score: 189.889 bits (481), Expect = 9.154e-51
Identity = 169/666 (25.38%), Postives = 297/666 (44.59%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDY-IKHINI----FELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSR--EGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRK--RPLTGVCTSWME-KMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVL--LGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + YGSQTG A+  A  L      Y ++ ++     ++L D+    EI K +  +   +T G+GD  DNA  F   ++      L+  K+ V GLG+  Y +F    K +DQ LE  GA+R +   + DD   LE     W +  +     +C    ++     S   +             EL+   + +DMD   +    +        Y N+    +   P + ++   +++ +L  G  + +  +             +++ ++K +++ GD V + P N  + V+ I   L     + + ++ L  L+   N++   P           + ++ L +  D+  P     L  +++Y    S EQ  L ++ S   EG+  Y   + E    +L +L  +PS + PI  L E+LPRL+ R YS+     V      +    ++   K  R   GV TSW+  K     N +   +P+++RK+   F +   P+ P I++GPGTGVAPF+GF+Q    L+ + + +G   L++GCR  + D++++++L  F   G LT L V FSR+                +  YVQH L    + L  L+    A ++VCGD+  M+KDV  T+ +++   G  E  Q    A  ++  +  +  Y  DVW
Sbjct:   82 VFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDK-SLVVFCMATYGEGDPTDNAQDFYDWLQETDVD-LTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPA---VCEFFGVEATGEESSIRQY------------ELV---VHEDMDTAKVYTGEMGRL---KSYENQKPPFDAKNPFLAAV---TTNRKLNQGTERHLMHLE------------LDISDSKIRYESGDHVAVYPANDSTLVNQIGEILGA---DLDVIMSLNNLDEESNKKHPFP--------CPTTYRTALTYYLDITNPPRTNVLYELAQYASEPS-EQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRTKEPAGENGRRALVPMFVRKSQ--FRLPFKPTTPVIMVGPGTGVAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQ--------------AHKVYVQHLLKRDKEHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQ----AVDYVKKLMTKGRYSLDVW 677

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BLAST of methionine synthase reductase vs. Ensembl Mouse
Match: Por (P450 (cytochrome) oxidoreductase [Source:MGI Symbol;Acc:MGI:97744])

HSP 1 Score: 162.54 bits (410), Expect = 1.359e-41
Identity = 144/570 (25.26%), Postives = 257/570 (45.09%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDY-IKHINI----FELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSR--EGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRK--RPLTGVCTSWME-KMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDN 1756
            + YGSQTG A+  A  L      Y ++ ++     ++L D+    EI K +  +   +T G+GD  DNA  F   ++      L+  K+ V GLG+  Y +F    K +DQ LE  GA+R +   + DD   LE     W +  +     +C    ++     S   +             EL+   + +DMD   +    +        Y N+    +   P + ++   +++ +L  G  + +  +             +++ ++K +++ GD V + P N  + V+ I   L     + + ++ L  L+   N++   P           + ++ L +  D+  P     L  +++Y    S EQ  L ++ S   EG+  Y   + E    +L +L  +PS + PI  L E+LPRL+ R YS+     V      +    ++   K  R   GV TSW+  K     N +   +P+++RK+   F +   P+ P I++GPGTGVAPF+GF+Q    L+ + + +G   L++GCR  + D++++++L  F   G LT L V FSR+ 
Sbjct:   82 VFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDK-SLVVFCMATYGEGDPTDNAQDFYDWLQETDVD-LTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPA---VCEFFGVEATGEESSIRQY------------ELV---VHEDMDTAKVYTGEMGRL---KSYENQKPPFDAKNPFLAAV---TTNRKLNQGTERHLMHLE------------LDISDSKIRYESGDHVAVYPANDSTLVNQIGEILGA---DLDVIMSLNNLDEESNKKHPFP--------CPTTYRTALTYYLDITNPPRTNVLYELAQYASEPS-EQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRTKEPAGENGRRALVPMFVRKSQ--FRLPFKPTTPVIMVGPGTGVAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQ 599

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BLAST of methionine synthase reductase vs. Ensembl Mouse
Match: Ndor1 (NADPH dependent diflavin oxidoreductase 1 [Source:MGI Symbol;Acc:MGI:1926047])

HSP 1 Score: 155.221 bits (391), Expect = 2.484e-39
Identity = 170/667 (25.49%), Postives = 286/667 (42.88%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDA--VGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPM-PSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQS-FYTKCLRETSMPVLDLLNWFP--SCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSK-----VDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +L+GSQTG A+  AE L  + +       +  LD    +  I +    I +C+TTG GD PDN   F R I  K      L    + VLGLGD++Y+ F   +K + + L   G        + DD   +G +  ++PW+  L+E    M   +P+D                             + +   G    VP LPS F+        SI      + +S P  P S+ +  +  V    ++T     + V     ++ ++   +  GD V ILP N+E+        L +   + N    L+  E        +P+   V      +L S  L +  + +      L  +S++    + E+ +LLEL S  GQ   +  C R     +L++L  FP  +  IP   LL+++PR++PRA+S+    S   A  +     V +   QT  K P  G+C+SW+  +       + ++P+++R     F   + P  P I++G GTGVAPF   +Q  E++ +        +LFFGCR  ++DF ++ + +     G LT L   FSR+       EQK         YVQH L     ++ +LL  Q A  ++ G++  +  DV E   ++     E   +  DA +++  ++    +  + W
Sbjct:    8 VLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVANLIRE-PLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPPCLGDDQHELGPDAAIDPWVGDLWEKIMVMYP-VPLD-----------------------------IPEIPHG----VP-LPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQPFLAPVITNQRVTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHTQQFCQVLCL---DPNQFFTLKPREPGVPDPPGLPQPCTV-----WNLVSQYLDIASVPRRSFFELLACLSQH----ALEREKLLELSSARGQEELWEYCSRPRRT-ILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIA---SSLLAHPRRLQILVAVVKYQTRLKEPRHGLCSSWLASLNPGQAGPV-RVPLWVRPGSLVFP--KTPDTPIIMVGAGTGVAPFRAAIQ--ERVAHGQTG---NFLFFGCRQRDQDFYWQTEWQKLEQKGWLT-LVTAFSREQ------EQK--------VYVQHRLRELGPLVWELLDGQGAYFYLAGNAKYLPTDVSEALMSIF--QEEGRLSTADASAYLARLQQTLRFQTETW 597

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BLAST of methionine synthase reductase vs. UniProt/SwissProt
Match: sp|Q8C1A3|MTRR_MOUSE (Methionine synthase reductase OS=Mus musculus OX=10090 GN=Mtrr PE=1 SV=2)

HSP 1 Score: 350.132 bits (897), Expect = 8.224e-109
Identity = 232/723 (32.09%), Postives = 377/723 (52.14%), Query Frame = 2

Query:   62 LKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYE-IAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELL--------------GD---------------------------HLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAY-----SLCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKM-------------AKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ++   +LY +Q GQAK+IAE +  +   +    ++  + + EK     +    +++ STTG GD PD A KF++ I  K     Y ++ +Y +LGLGD+ Y+ FCN  K ID+ L+  GA+RFY +  ADD VGLE+VVEPW+DGL+  + K   S   + G +N+S T   +           ELL              G+                           H    +   +L++PA+P  +L +  + ++S+            +PS D    +  +    ++T   A+KS     +++   ++  +PGDS  +   N++ EV+ +L RL + +   + V+     +  +   A +P H+     G+ SL+ IL W  ++R    K  LR ++E+    + E+RRL ELCS++G + Y + +R+ S+ +LDLL  FPSCQ P+  LLE LP+L+PR Y     SL   + + F F+ V+  P  T    P  GVCT W+  +             A   +    +I I  R   N F + E+PS P I++GPGTGVAPF+GFLQ+ EKL+ ++ +   G +WLFFGCR+++RD++F+++L HF  +G+LTHL V FSRD   + G+E          KYVQ  L  HS+ ++  L+ +N  ++VCGD+  M+KDV +T   ++  ++E    K +A   +  ++ +K YL+D+W
Sbjct:    1 MRRFLLLYATQRGQAKAIAEEISEQAVSHGFSADLHCISESEKYDLKTETGPLVMVVSTTGTGDPPDTARKFVKEIHNKTLPTDYFAHLRYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQRFYDTGHADDCVGLELVVEPWIDGLWAALTKHFKS---LGGQENMSDTLSRASDAPLSTAMKPELLHIQSQVELLRLEDVGERDSELREQNETNRGQQGRIEDFDSSLVHSVPPLSQSSLSIPAVPPEYLEV--HLQESLGQEE----NQASVPSGDPSFQV-PISKAIRLTTNDAVKSTLLLELDISKIEFSHQPGDSFNVTCPNSDREVEELLQRLQLADKRAHRVILKIKTDTKKKGAA-LPAHV---PEGR-SLQFILTWCLEIRAVPKKAFLRALAEHT-SSATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLSLLLEHLPKLQPRPYSCASSSLRHPDKLHFVFNIVEFPP-STTAASPRKGVCTGWLATLVAPFLQPNTDVSNADSGDTLAPEIRISPRAT-NAFHLPEDPSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGKFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPD-GEEAP-------AKYVQDNLQRHSQQVARTLLQENGYIYVCGDAKNMAKDVNDTLIGII--SNEAGVDKLEAMKTLATLKQEKRYLQDIW 695

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BLAST of methionine synthase reductase vs. UniProt/SwissProt
Match: sp|Q4JIJ2|MTRR_BOVIN (Methionine synthase reductase OS=Bos taurus OX=9913 GN=MTRR PE=2 SV=1)

HSP 1 Score: 338.191 bits (866), Expect = 3.166e-104
Identity = 237/717 (33.05%), Postives = 372/717 (51.88%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKD--MCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKE-LLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDS--ISNFHEPLITSMPMPSSDS---------------ELVMGE-----------------VQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLES------VSFAFSKVDIAPIQT---FRKRPLTGVCTSWMEKMAKF-------------HNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNEN--QNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +LY +Q GQAK+IAE +  K   Y    ++  + + +K     +    +++ STTG+GD PD A KF++ IK     P +L++ +Y +LGLGD+ Y+ FCN  K ID+ L+  GA+RFY +  ADD VGLE+VVEPW++GL+   +   + +    D  + L++    S+  + P   + E  +G     D  GK   V        N + +N+ S  I +F   L  S+P  S  S               E  +G+                 V    ++T   AIK+     +++    + ++PGD+  ++  N++SEV  +L RL + +  ++ V      +  +   A +P+H+  R     SL+ +L W  ++R    K  LR ++++    SAE+RRL ELCSR+G + YT+ +RE    + DLL  FPSCQ P+  LLE LP+L+PR YS C   S      + F F+ V+     T    R+    GVCT W+  + +                    KI I  R   N F + ++PS+P I++GPG GVAPFIGFLQ+ EKL+ ++   + G  WLFFGCR++ERD++F+ +L HF   G+LTHL V FSRD     G+E+         KYVQ  L  HSK ++ +L+  +  V+VCGD+  M+KDV +    ++  + E    K +A   +  ++ +K YL+D+W
Sbjct:    6 LLYATQRGQAKAIAEEISEKAVTYGFSADLHCISESDKYDLKTETAPLVMVVSTTGNGDPPDTARKFVKAIKDKTLPPDFLAHLRYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQRFYDTGHADDCVGLELVVEPWINGLWAALEKHFLSNRGREDTSETLTMASHASRDAVTPELLHVESQVGLLKLDDSGGKAAKVLE-----QNAVNSNQSSTLIVDFEASLTHSVPPLSQASLNIPSLPPEYLEVHLEEALGQEESHASVSLVDPVFHVPVSKAVQLTTNDAIKTTLLIELDISKTDFSYQPGDAFNVICPNSDSEVQFLLQRLQLADRREHHVAVTIKADTRKKGAA-LPQHVPER----CSLQFLLTWCLEIRAVPKKAFLRALADHT-GDSAERRRLQELCSRQGAADYTRFVREAGACLSDLLRAFPSCQPPLGLLLEHLPKLQPRPYS-CASSSLFHPGKLHFIFNIVEFLSNTTEVILRR----GVCTGWLATLVESILQPYMCANHVDGKKALAPKISISPR-TTNSFHLPDDPSVPIIMVGPGAGVAPFIGFLQHREKLQEQHPGGHFGATWLFFGCRHKERDYLFRDELRHFLKCGVLTHLEVSFSRD--VAVGEEEG------PAKYVQDSLQRHSKQVAGVLLQDSGYVYVCGDAKNMAKDVHDALVEII--SRETGVEKLEAMKTLATLKEEKRYLQDIW 695

[Close]

BLAST of methionine synthase reductase vs. UniProt/SwissProt
Match: sp|Q9UBK8|MTRR_HUMAN (Methionine synthase reductase OS=Homo sapiens OX=9606 GN=MTRR PE=1 SV=4)

HSP 1 Score: 334.724 bits (857), Expect = 5.318e-103
Identity = 240/724 (33.15%), Postives = 381/724 (52.62%), Query Frame = 2

Query:   62 LKMTCILYGSQTGQAKSIAENL--YAKLKDYIKHIN-IFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAK----------DMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNN-EDSISNFHEPLI-TSMPMPSSDSELVMGEVQD------------------------ITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV------SFAFSKVDI---APIQTFRKRPLTGVCTSWMEKMAK------FHNEQ-------IWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNE--NQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ++   +LY +Q GQAK+IAE +   A +  +   ++ I E D  +   E   L   +++ STTG GD PD A KF++ I+       + ++ +Y +LGLGD+ Y+ FCN  K ID+ L+  GAR FY +  ADD VGLE+VVEPW+ GL+   +          ++   +P+      S    + K E+  IE+  ELL    +   D + L   A+ S   N++  + E S++    PL   S+ +P    E +   +Q+                          ++T   AIK+     +++ N  + ++PGD+  ++  N++SEV S+L RL + +  ++CV+     +  +   A +P+H+        SL+ I  W  ++R    K  LR + +Y    SAE+RRL ELCS++G + Y++ +R+    +LDLL  FPSCQ P+  LLE LP+L+PR YS C   S+       F F+ V+    A  +  RK    GVCT W+  +         H            KI I  R   N F + ++PSIP I++GPGTG+APFIGFLQ+ EKL+ +  + N G +WLFFGCR+++RD++F+K+L HF   GILTHL V FSRD P   G+E+         KYVQ  +  H + ++ +L+ +N  ++VCGD+  M+KDV +    ++  + E    K +A   +  ++ +K YL+D+W
Sbjct:    1 MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPL---VVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS--PASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKG-ATLPQHI----PAGCSLQFIFTWCLEIRAIPKKAFLRALVDYT-SDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYS-CASSSLFHPGKLHFVFNIVEFLSTATTEVLRK----GVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPR-TTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPV--GEEEA------PAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQII--SKEVGVEKLEAMKTLATLKEEKRYLQDIW 697

[Close]

BLAST of methionine synthase reductase vs. UniProt/SwissProt
Match: sp|Q17574|MTRR_CAEEL (Methionine synthase reductase OS=Caenorhabditis elegans OX=6239 GN=mtrr-1 PE=3 SV=1)

HSP 1 Score: 268.855 bits (686), Expect = 2.209e-78
Identity = 212/720 (29.44%), Postives = 352/720 (48.89%), Query Frame = 2

Query:   50 LCDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELL--------------GDHLAKDM---------------------DGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSM------PMPSSDSELVMGEVQDITKITNKYA--IKSVHRATINVPN--AKWKWKPGDSVGILPFNAESEVDSILSRLSVPE-TEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLES--VSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIW-KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN---IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHH-SKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNH--EKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + DFL    I +GSQTGQA++IA++L  K +       +  LD+ EK F +++     I+ S+TGDGDAPDN ++F+R I     + +YL N  Y +LGLGD+NYS++    + ID+ L + GA R +    ADD VGLE+ VEPW++  +        +I  D    ++ +  +   ++K  E  K LL              G  +  DM                     + +NL VP  P PF+        S+SN   P  T +       MP   ++     V     +T+ ++  IK+    T++  +  A+ +++PGD++     N   EV+ IL R  V +  ++ C + +       N  A++P H+    +   +L+ +     D+R+   +  +R+++E       E+RRLLELCS +G   +T  +R   + + D+L  FP+ + P+ RL+E+LPRL PR YS+   E+      +S+++  P    R+    G+ T W+  +      Q+  K P   R    G T      +P +++GPGTGV+ F+ FL +  KLK ++ +     P  LFFGCR+   D I+  +LE F + GILT L +C S         EQK        + VQ  L  +  K+L  L  +  +++F+CGD+ GMSKDV + +S+++  +     ++ K+     +  ++    Y+EDVW
Sbjct:    1 MTDFL----IAFGSQTGQAETIAKSLKEKAELIGLTPRLHALDENEKKFNLNEEKLCAIVVSSTGDGDAPDNCARFVRRINRNSLENEYLKNLDYVLLGLGDSNYSSYQTIPRKIDKQLTALGANRLFDRAEADDQVGLELEVEPWIEKFFATLASRF-DISADKMNAITESSNLKLNQVKTEEEKKALLQKRIEDEESDDEGRGRVIGIDMLIPEHYDYPEISLLKGSQTLSNDENLRVPIAPQPFIV------SSVSNRKLPEDTKLEWQNLCKMPGVVTKPFEVLVVSAEFVTDPFSKKIKTKRMITVDFGDHAAELQYEPGDAIYFCVPNPALEVNFILKRCGVLDIADQQCELSINPKTEKIN--AQIPGHV----HKITTLRHMFTTCLDIRRAPGRPLIRVLAESTS-DPNEKRRLLELCSAQGMKDFTDFVRTPGLSLADMLFAFPNVKPPVDRLIELLPRLIPRPYSMSSYENRKARLIYSEMEF-PATDGRRHSRKGLATDWLNSLRIGDKVQVLGKEPARFRLPPLGMTKNSAGKLPLLMVGPGTGVSVFLSFLHFLRKLKQDSPSDFVDVPRVLFFGCRDSSVDAIYMSELEMFVSEGILTDLIICES---------EQKG-------ERVQDGLRKYLDKVLPFLTASTESKIFICGDAKGMSKDVWQCFSDIVASDQGIPDLEAKKK----LMDLKKSDQYIEDVW 681

[Close]

BLAST of methionine synthase reductase vs. UniProt/SwissProt
Match: sp|Q498R1|MTRR_RAT (Methionine synthase reductase OS=Rattus norvegicus OX=10116 GN=Mtrr PE=2 SV=2)

HSP 1 Score: 249.595 bits (636), Expect = 3.622e-71
Identity = 160/483 (33.13%), Postives = 268/483 (55.49%), Query Frame = 2

Query:  647 NLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAY-----SLCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWM------------EKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNE--NQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +L++PA+   +L + Y  E    + ++    S+P PS D  +    +    ++T   AIK+     +++   ++  +PGDS  ++  N+ SEV+ +L RL + + + + V+    ++  +   A +P+H  V E    SL+ I  W  ++R    K  LR +S+Y    + E+RRL ELCS++G + Y + +R+ S+ +LDLL  FPSCQ P+  LLE LP+L+PR Y     SL   + + F F+ V++ P  T       GVCT W+            E +   H++ +    +   +  N F + ++ S P I++GPGTGVAPF+GFLQ+ EKL+ +  + N G +WLFFGCR+++RD++F+++L HF  +G+LTHL V FSRD      +E          KYVQ  L HHS+ ++  L+ +N  ++VCGD+  M+KDV +    ++  + E    K +A   +  ++ +K YL+D+W
Sbjct:  239 SLSIPAVSPEYLEV-YLQESLGQDENQ---ASVP-PSVDP-IFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADKQAHRVILKIKMDTKKKG-ASLPQH--VPEGS--SLQFIFTWCLEIRAVPKKAFLRALSDYTS-DATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCASSSLLHPDKLHFVFNIVEL-PSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPA-------KYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEII--SKEAGVDKLEAMKTLATLKQEKRYLQDIW 699

HSP 2 Score: 113.62 bits (283), Expect = 1.037e-24
Identity = 58/147 (39.46%), Postives = 89/147 (60.54%), Query Frame = 2

Query:   62 LKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLY 496
            ++   +LY +Q GQAK+IAE +  +   +    ++  + + EK     +    +++ STTG GD PD A KF++ I  K     + ++  Y +LGLGD+ Y+ FCN  K ID+ L+  GA+ FY +  ADD VGLE+VVEPW+DGL+
Sbjct:    1 MRRFLLLYATQRGQAKAIAEEISEQALSHGFSADLHCVSESEKYDLKTETGPLVMVVSTTGTGDPPDTARKFVKEIHNKTLPTDFFAHLWYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQHFYDTGHADDCVGLELVVEPWIDGLW 147

[Close]

BLAST of methionine synthase reductase vs. TrEMBL
Match: C3XSJ5 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_282133 PE=4 SV=1)

HSP 1 Score: 408.683 bits (1049), Expect = 9.910e-129
Identity = 241/705 (34.18%), Postives = 394/705 (55.89%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLY-EIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKEL-------LGDHLAKD--------MDG------------------KNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAY-----SLCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIW-------KIPIYLRK-NMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNI--GPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +LYGSQTGQAK+IAE ++   + +    ++F L+  EK F++ K +  + +CSTTGDGD PDNA+KF R +K       +L++  + VLGLGD+NY+NFCNC KT+D+ L+  GA+ FY +  ADDAVGLEIVV+PW++GL+  + K + +EI       +S ++          ++  +        L D   KD         DG                    LT+PA   P+L + ++ E+S+     PL +  P PS+ +++VM  V   T++T   A+K+     +++ +  +K++PGDS G++  N E+EV  ++ RL + +   +     ++++  + R A VP HL  R     +++  LL   ++R    K  LR++ E+    + ++RRL ELCS++G + Y   +RE ++ +LD+L  FPSC  P  RLLE+LPRL+PR Y      L   + + F F+ V I P  + R  P TGVCT W++++       ++       K+   + +   N F +  + S+P I++GPGTGVAPF+GFLQ+ EK +  + +   GP WLF+GCR+ +RD++++++LE  A +G+L HL VCFSR+ P     +       P  +YVQ  L HH   +  +L+++ A ++VCGD+  M+KDV E  + ++     K+   R+    +  +R  + Y+ED+W
Sbjct:   13 LLYGSQTGQAKAIAEEIHENAEKHGLRTDLFGLELTEKKFDVTKESCVVFVCSTTGDGDPPDNATKFFRRLKKKTLPSDHLAHLNFAVLGLGDSNYTNFCNCPKTLDKRLQELGAKPFYPTGYADDAVGLEIVVDPWIEGLWTAVRKQLGTEINGQRDDKVSESQSEIVAVKSCEDSTNDRTSTAYTDLADVADKDTHSIVPENQDGVIQQAGPSLRVSAPPLCDSGLTLPAKSVPYLEVEFHPEESLL----PLQSGCPFPSAAADVVMATVTMATRLTRHDAVKTALDIELDILDTSFKYEPGDSFGVVCPNDETEVQDLIDRLGLTD-HADTTFSAKVIKGTKKRAAAVPAHLPAR----CTIRYALLTCLEIRAVPKKAFLRMLVEHT-SDAVQKRRLQELCSKQGTADYAAFIREPNLRLLDVLTAFPSCCPPFERLLEMLPRLQPRPYSVSSSPLVSPDRLHFVFNIVHI-PSGSGRAAPCTGVCTGWLDRLTGHMQTGVYVGMAEEDKVAEKIGQITNNHFRLPSDLSVPIIMVGPGTGVAPFVGFLQHREKQREISHDAVCGPSWLFYGCRHRDRDYLYREELERLAAAGVLDHLVVCFSREEPVTMETDGA-----PPARYVQDNLHHHGDDVGRMLLDEGAVLYVCGDAKNMAKDVNEVITQIVQKYKGKLSEARNT---VFQLRQDRHYIEDIW 698

[Close]

BLAST of methionine synthase reductase vs. TrEMBL
Match: A0A2D0PRR0 (methionine synthase reductase OS=Ictalurus punctatus OX=7998 GN=mtrr PE=4 SV=1)

HSP 1 Score: 371.703 bits (953), Expect = 1.661e-114
Identity = 240/715 (33.57%), Postives = 386/715 (53.99%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQ-PK-YLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPI----------DGFQ------NLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGK-----------------NLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDI-----TKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLE-----SVSFAFSKVDIAPIQTFRKRPLTGVCTSWME------------KMAKFHNEQIWKIP-IYLRKNMNG-FTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ILYGSQ GQA+SIAE L  +  ++    ++  L   +K     + N  + + STTGDG+ PD A KF+R IK    P+ + S+  Y +L LGDTNY++FCNC KTID+ L+  GA  FY + +ADD  GLE+V++PW+DGL++  K + +++P           DG Q       L  T +  K+      +  +   +   + +D +                 +L++PALP  +L + + +              +P    ++ +V      +      ++T   A+K      +++ N    ++PGD+  +L  N E+EV+ +L RLS+ + +KN  V L+LL+  + + A+VP ++      K +L+ +L W  ++R    K  LR + + C  ++ E+RRL ELCSREG + Y + +R+ S+ +LDLL  FPSC  P+  L+E LP+L+PRAYS           V   FS V         +R  TG+CT W+             K A   +     +P +++   +N  F +  +P++P +++GPG+GVAPF+GFLQ  EK +  NQ+   G  WLFFGCR+++RDFIF+++LE FA    L+ L VCFSR  P  SG E     +P   KYVQH LL H++ ++ +L+ +N R++VCGD+  M+KDV +T   + +G   ++  K ++   +  +R +K YL+D+W
Sbjct:   12 ILYGSQKGQAQSIAEQLADQAAEHGFEADVSCLSQADKYNLEKEHNPVVFVVSTTGDGEPPDTALKFVRSIKKKSLPRDHFSHLHYGLLALGDTNYTDFCNCGKTIDRRLQELGANHFYETGLADDGTGLEVVLDPWIDGLWDALKKIFAKMPASDLIRSISLSDGHQLVAAQEKLESTARSLKLLDISDVDAGKFKPESETESLDAETPLEASLNRSIAPLSQSSLSIPALPPSYLEVCFGD--------------VPTGEEEAHVVARGFHAVPISRAVRLTRDDAVKPAILLELDIKNENVSYQPGDAFDLLCPNRETEVEDLLHRLSLRD-KKNHSVHLQLLKTTKKKGARVPPYI----TEKCTLQYLLTWCLEIRSIPKKAFLRSLVD-CTQQAQEKRRLQELCSREGAADYDRFVRKPSVCILDLLRAFPSCTPPLSLLIEHLPKLQPRAYSAASSSLRHPGKVHIVFSVVRFPACAEHPER--TGLCTGWLADRVSTIIEPYGTKQASRESVDYAALPKVHISPRLNNTFRLPSDPTVPMVMVGPGSGVAPFVGFLQQREKERERNQDGAFGETWLFFGCRHKDRDFIFREELERFAEDKTLSRLKVCFSRAEPDRSGSE----AEP---KYVQHNLLLHAEHVARVLLKENGRLYVCGDAKNMAKDVNDTLMEI-IGAGLQVD-KLESMKTVAKLREEKRYLQDIW 695

[Close]

BLAST of methionine synthase reductase vs. TrEMBL
Match: F1RE28 (5-methyltetrahydrofolate-homocysteine methyltransferase reductase OS=Danio rerio OX=7955 GN=mtrr PE=4 SV=2)

HSP 1 Score: 370.933 bits (951), Expect = 2.580e-114
Identity = 248/723 (34.30%), Postives = 387/723 (53.53%), Query Frame = 2

Query:   53 CDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPI-------------------DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKN----------------LTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWK-WKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLE-----SVSFAFSKVDIA--PIQTFRKRPLTGVCTSWM----EKMAKFHNEQIW----------KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQ--NIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            C+      ILYGSQ GQA+SIAE +  +  ++    +I  L   +K     +    + + STTGDGD PD A KF+R IK       +LS+ +Y +LGLGDTNY+NFCN  KTID  L+  GA+ FY +  ADD  GLE+VV+PW++GL++  K   S +                     D  +NL +  ++ K+        K +  D +A ++   +                L VPALP  +L I+    +++            +P  D    +  +    ++T   A+K+     +++   + + ++PGD+  IL  N +SEV+ +L +L + + +KNC V++ LL+N   + AKVP H  + +NG  SL+ IL W  ++R    K  LR + ++    ++E+RRLLELCS++G + Y   +R++S+ VLDLL  FPSC  P+  L E LP+L+PRAYS           V   F+ V+    P    RK    G+CT W+      + + H   +           K+ +  R + + F +  +P +P +++GPGTGVAPFIGFLQ  EK +  NQ    G +WLFFGCR++++DF+F+++LE F ++G L+HL VCFSRD P    D  +   +P    YVQH L+ H+K L+ +L+     ++VCGD+  M+KDV +T   + +GN  ++  K DA   + G+R  K YL+D+W
Sbjct:    3 CEAAAHFLILYGSQRGQAQSIAEEICQQAAEHGFTADISCLSKHDKYNLDSESRPVVFVVSTTGDGDPPDTALKFVRKIKNKSLPHDHLSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHADDGTGLEVVVDPWIEGLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLKLSEVDSPKGKTVTSDSIATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEE--------TVLPDKDGYFEV-PISKAVQLTQDDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVEELLLKLDL-QMQKNCTVQVNLLKNTSKKAAKVPLH--IPQNG--SLQFILTWCLEIRSTPKKAFLRALVDFT-QNASEKRRLLELCSKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSLLFEHLPKLQPRAYSAASSSLQHPGKVHLVFNVVEFPARPEHPARK----GLCTGWLVDHVSSILEPHGTALASERPGTSALPKVHVRARPS-STFHLPSDPCVPVVMVGPGTGVAPFIGFLQQREKEREANQEATFGEMWLFFGCRHKDKDFLFREELEKFVHNGTLSHLIVCFSRDEP----DAAETVNRP---TYVQHNLILHAKNLAKILLEDKGCLYVCGDAKNMAKDVNDTLLEI-IGNELQLD-KLDAMKIVAGLREDKRYLQDIW 696

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BLAST of methionine synthase reductase vs. TrEMBL
Match: A0A2R8QQ95 (5-methyltetrahydrofolate-homocysteine methyltransferase reductase OS=Danio rerio OX=7955 GN=mtrr PE=4 SV=1)

HSP 1 Score: 371.318 bits (952), Expect = 3.197e-114
Identity = 249/731 (34.06%), Postives = 390/731 (53.35%), Query Frame = 2

Query:   29 FVYIMHLLCDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPI-------------------DGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKN----------------LTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWK-WKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLE-----SVSFAFSKVDIA--PIQTFRKRPLTGVCTSWM----EKMAKFHNEQIW----------KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQ--NIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            F    ++ C+      ILYGSQ GQA+SIAE +  +  ++    +I  L   +K     +    + + STTGDGD PD A KF+R IK       +LS+ +Y +LGLGDTNY+NFCN  KTID  L+  GA+ FY +  ADD  GLE+VV+PW++GL++  K   S +                     D  +NL +  ++ K+        K +  D +A ++   +                L VPALP  +L I+    +++            +P  D    +  +    ++T   A+K+     +++   + + ++PGD+  IL  N +SEV+ +L +L + + +KNC V++ LL+N   + AKVP H  + +NG  SL+ IL W  ++R    K  LR + ++    ++E+RRLLELCS++G + Y   +R++S+ VLDLL  FPSC  P+  L E LP+L+PRAYS           V   F+ V+    P    RK    G+CT W+      + + H   +           K+ +  R + + F +  +P +P +++GPGTGVAPFIGFLQ  EK +  NQ    G +WLFFGCR++++DF+F+++LE F ++G L+HL VCFSRD P    D  +   +P    YVQH L+ H+K L+ +L+     ++VCGD+  M+KDV +T   + +GN  ++  K DA   + G+R  K YL+D+W
Sbjct:    9 FSSFYNMPCEAAAHFLILYGSQRGQAQSIAEEICQQAAEHGFTADISCLSKHDKYNLDSESRPVVFVVSTTGDGDPPDTALKFVRKIKNKSLPHDHLSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHADDGTGLEVVVDPWIEGLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLKLSEVDSPKGKTVTSDSIATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEE--------TVLPDKDGYFEV-PISKAVQLTQDDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVEELLLKLDL-QMQKNCTVQVNLLKNTSKKAAKVPLH--IPQNG--SLQFILTWCLEIRSTPKKAFLRALVDFT-QNASEKRRLLELCSKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSLLFEHLPKLQPRAYSAASSSLQHPGKVHLVFNVVEFPARPEHPARK----GLCTGWLVDHVSSILEPHGTALASERPGTSALPKVHVRARPS-STFHLPSDPCVPVVMVGPGTGVAPFIGFLQQREKEREANQEATFGEMWLFFGCRHKDKDFLFREELEKFVHNGTLSHLIVCFSRDEP----DAAETVNRP---TYVQHNLILHAKNLAKILLEDKGCLYVCGDAKNMAKDVNDTLLEI-IGNELQLD-KLDAMKIVAGLREDKRYLQDIW 710

[Close]

BLAST of methionine synthase reductase vs. TrEMBL
Match: W5U6V5 (Methionine synthase reductase OS=Ictalurus punctatus OX=7998 GN=Mtrr PE=2 SV=1)

HSP 1 Score: 370.548 bits (950), Expect = 3.490e-114
Identity = 240/715 (33.57%), Postives = 385/715 (53.85%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQ-PK-YLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPI----------DGFQ------NLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGK-----------------NLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDI-----TKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLE-----SVSFAFSKVDIAPIQTFRKRPLTGVCTSWME------------KMAKFHNEQIWKIP-IYLRKNMNG-FTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ILYGSQ GQA+SIAE L  +  ++    ++  L   +K     + N  + + STTGDG+ PD A KF+R IK    P+ + S+  Y +L LGDTNY++FCNC KTID+ L+  GA  FY + +ADD  GLE+V++PW+DGL++  K + +++P           DG Q       L  T +  K+      +  +   +   + +D +                 +L+ PALP  +L + + +              +P    ++ +V      +      ++T   A+K      +++ N    ++PGD+  +L  N E+EV+ +L RLS+ + +KN  V L+LL+  + + A+VP ++      K +L+ +L W  ++R    K  LR + + C  ++ E+RRL ELCSREG + Y + +R+ S+ +LDLL  FPSC  P+  L+E LP+L+PRAYS           V   FS V         +R  TG+CT W+             K A   +     +P +++   +N  F +  +P++P +++GPG+GVAPF+GFLQ  EK +  NQ+   G  WLFFGCR+++RDFIF+++LE FA    L+ L VCFSR  P  SG E     +P   KYVQH LL H++ ++ +L+ +N R++VCGD+  M+KDV +T   + +G   ++  K ++   +  +R +K YL+D+W
Sbjct:   12 ILYGSQKGQAQSIAEQLADQAAEHGFEADVSCLSQADKYNLEKEHNPVVFVVSTTGDGEPPDTALKFVRSIKKKSLPRDHFSHLHYGLLALGDTNYTDFCNCGKTIDRRLQELGANHFYETGLADDGTGLEVVLDPWIDGLWDALKKIFAKMPASDLIRSISLSDGHQLVAAQEKLESTARSLKLLDISDVDAGKFKPESETESLDAETPLEASLNRSIAPLSQSSLSTPALPPSYLEVCFGD--------------VPTGEEEAHVVARGFHAVPISRAVRLTRDDAVKPAILLELDIKNENVSYQPGDAFDLLCPNRETEVEDLLHRLSLRD-KKNHSVHLQLLKTTKKKGARVPPYI----TEKCTLQYLLTWCLEIRSIPKKAFLRSLVD-CTQQAQEKRRLQELCSREGAADYDRFVRKPSVCILDLLRAFPSCTPPLSLLIEHLPKLQPRAYSAASSSLRHPGKVHIVFSVVRFPACAEHPER--TGLCTGWLADRVSTIIEPYGTKQASRESVDYAALPKVHISPRLNNTFRLPSDPTVPMVMVGPGSGVAPFVGFLQQREKERERNQDGAFGETWLFFGCRHKDRDFIFREELERFAEDKTLSRLKVCFSRAEPDRSGSE----AEP---KYVQHNLLLHAEHVARILLKENGRLYVCGDAKNMAKDVNDTLMEI-IGAGLQVD-KLESMKTVAKLREEKRYLQDIW 695

[Close]

BLAST of methionine synthase reductase vs. Ensembl Cavefish
Match: mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:NCBI gene;Acc:103046907])

HSP 1 Score: 370.163 bits (949), Expect = 2.310e-117
Identity = 251/731 (34.34%), Postives = 371/731 (50.75%), Query Frame = 2

Query:   53 CDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGD-----HLAKDMDGKN-------------------------------------LTVPALPSPFLNIIYNN----EDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAY-----SLCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEK------------MAKFHNEQIWKIP-IYLRKNM-NGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            C       ILYGSQ GQA+SIAE +  +  ++     I  L   +K     +    + + STTGDG+ PD A KF++ IK       + S+  Y +LGLGDTNY+NFCNC KTID+ L+  GA+ FY +  ADD  GLE+VV+PW++GL+E  K   S +  D  Q  +   + ++   +     +E L       HL K  D +                                      L VPALP  +L +   +    E+S+    E     +P            V     +T   A+KS     +++ +    ++PGD+  +L  N  SEV+ +LSRL V +    CV      +  +   A+VP ++      K +L+ +L W  ++R    K  +R + E+    S E+RRL ELCSREG + Y K +R+T++ +LDLL  F SC  P+  L+E LP+L+PRAY     SLC    V F FS V+        +R  TG+CT W+               A         +P +Y+R  + N F +  +PS+P +++GPGTGVAPFIGFLQ  EK + E QN   G  WLFFGCR+++RDFIF+++LE F  +  L+HL VCFSR       DEQ      P  +YVQH LL H+K +  +L+ +N  ++VCGD+  M+KDV +T    +LGN  ++  K ++   +  +R +K YL+D+W
Sbjct:    3 CGVAPRFLILYGSQRGQAQSIAEEISEQATEHGFLAKISCLSKGDKYNLDREHGPVVFVVSTTGDGEPPDTALKFVKKIKNKSLPGDHYSHLHYALLGLGDTNYANFCNCGKTIDKRLQELGAKHFYATGHADDGTGLEVVVDPWIEGLWEALKKAFSRMS-DSNQEGTAQGEATEKSTQQGAEIQEKLDSSAVSLHLLKLGDVETQKEKAETSASESETTEPSGAPLEPALIRSVPPLSQSALNVPALPPAYLEVRLEDVPVEEESVHVLKEDF-REVP------------VSRALHLTRDDAVKSAILVELDIADQDMPYQPGDAFDVLCPNRASEVEELLSRLGVGDQRNRCVYLQLRKDTKKKG-AQVPSYI----PQKCTLQYLLTWCLEIRSVPKKAFVRALVEWT-QDSREKRRLQELCSREGSADYNKFVRDTNVCLLDLLQTFSSCSPPLSLLIEHLPKLQPRAYSAASSSLCHPGKVHFVFSVVEFPACAEHPER--TGLCTGWLVHHVSPILQPCGTITAAKKTADCSALPKVYVRSRISNTFHLPSDPSVPVVMVGPGTGVAPFIGFLQQREKEREERQNGPFGETWLFFGCRHKDRDFIFREELERFVENETLSHLKVCFSR-------DEQDGNDPEPKPRYVQHQLLLHAKNIVHILLKENGYLYVCGDAKNMAKDVNDTLIE-MLGNELQLD-KLESMKMVAKLREEKRYLQDIW 702

[Close]

BLAST of methionine synthase reductase vs. Ensembl Cavefish
Match: mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:NCBI gene;Acc:103046907])

HSP 1 Score: 369.777 bits (948), Expect = 4.248e-117
Identity = 251/731 (34.34%), Postives = 371/731 (50.75%), Query Frame = 2

Query:   53 CDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGD-----HLAKDMDGKN-------------------------------------LTVPALPSPFLNIIYNN----EDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAY-----SLCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEK------------MAKFHNEQIWKIP-IYLRKNM-NGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            C       ILYGSQ GQA+SIAE +  +  ++     I  L   +K     +    + + STTGDG+ PD A KF++ IK       + S+  Y +LGLGDTNY+NFCNC KTID+ L+  GA+ FY +  ADD  GLE+VV+PW++GL+E  K   S +  D  Q  +   + ++   +     +E L       HL K  D +                                      L VPALP  +L +   +    E+S+    E     +P            V     +T   A+KS     +++ +    ++PGD+  +L  N  SEV+ +LSRL V +    CV      +  +   A+VP ++      K +L+ +L W  ++R    K  +R + E+    S E+RRL ELCSREG + Y K +R+T++ +LDLL  F SC  P+  L+E LP+L+PRAY     SLC    V F FS V+        +R  TG+CT W+               A         +P +Y+R  + N F +  +PS+P +++GPGTGVAPFIGFLQ  EK + E QN   G  WLFFGCR+++RDFIF+++LE F  +  L+HL VCFSR       DEQ      P  +YVQH LL H+K +  +L+ +N  ++VCGD+  M+KDV +T    +LGN  ++  K ++   +  +R +K YL+D+W
Sbjct:   16 CGVAPRFLILYGSQRGQAQSIAEEISEQATEHGFLAKISCLSKGDKYNLDREHGPVVFVVSTTGDGEPPDTALKFVKKIKNKSLPGDHYSHLHYALLGLGDTNYANFCNCGKTIDKRLQELGAKHFYATGHADDGTGLEVVVDPWIEGLWEALKKAFSRMS-DSNQEGTAQGEATEKSTQQGAEIQEKLDSSAVSLHLLKLGDVETQKEKAETSASESETTEPSGAPLEPALIRSVPPLSQSALNVPALPPAYLEVRLEDVPVEEESVHVLKEDF-REVP------------VSRALHLTRDDAVKSAILVELDIADQDMPYQPGDAFDVLCPNRASEVEELLSRLGVGDQRNRCVYLQLRKDTKKKG-AQVPSYI----PQKCTLQYLLTWCLEIRSVPKKAFVRALVEWT-QDSREKRRLQELCSREGSADYNKFVRDTNVCLLDLLQTFSSCSPPLSLLIEHLPKLQPRAYSAASSSLCHPGKVHFVFSVVEFPACAEHPER--TGLCTGWLVHHVSPILQPCGTITAAKKTADCSALPKVYVRSRISNTFHLPSDPSVPVVMVGPGTGVAPFIGFLQQREKEREERQNGPFGETWLFFGCRHKDRDFIFREELERFVENETLSHLKVCFSR-------DEQDGNDPEPKPRYVQHQLLLHAKNIVHILLKENGYLYVCGDAKNMAKDVNDTLIE-MLGNELQLD-KLESMKMVAKLREEKRYLQDIW 715

[Close]

BLAST of methionine synthase reductase vs. Ensembl Cavefish
Match: pora (NADPH--cytochrome P450 reductase [Source:NCBI gene;Acc:103023494])

HSP 1 Score: 191.045 bits (484), Expect = 1.491e-51
Identity = 172/666 (25.83%), Postives = 296/666 (44.44%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDY-----IKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNE-DSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSR--EGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPI----QTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + YGSQTG A+  A  L    + Y     +     +++ ++ +  E+   + A+   +T G+G+  DNA  F   +++     L    ++V GLG+  Y ++    K  D+ L   GA + +   + DD   LE   E ++    +    +C+   +   Q      +             EL+   +  D+D             LN +Y  E   + +F    +   P  + +  L   EV  + +  N+   + +    +++  +K ++  GD V + P N  S V+ +  RL +   + + V+ L+ L+   +++   P           + ++ L    D+  PL    L  +S+Y    S E+ R+  + S   EG++ Y   + E+   +L +L   PS   P+  L E+LPRL+ R YS+    S     + + I  +     T   R   GV T+W++   K        +PIY+RK+   F +    S P I+IGPGTG+APF+GFLQ     K +    G   L+FGCR++  DFI++++LE F  +G+LT L V FSRD       E K         YVQH L  + + L  L+ + NA ++VCGD+  M++DV E +  +         T   A  +   +  +  Y +DVW
Sbjct:   39 VFYGSQTGTAEEFATRLVKDAQRYGIKGMVADPEEYDMSELPRLTEVVN-SLAVFCMATYGEGEPTDNAQGFYDWMQVTDVS-LEGVHFSVFGLGNKTYDHYNAMGKYTDRRLAELGATQIFDLGLGDDDGNLE---EDFISWKAQFWPAVCAFFGVQPTQEECSVRQF------------ELV---VHNDID-------------LNEVYTGEVGCLKSFQ---VQKPPFDAKNPYL--AEVT-VNRKLNQGGSRHLMHLQLDISGSKIRYDAGDHVAVYPVNDVSLVNRLGERLGI---DLDTVITLKNLDEEASKKHPFP--------CPTTYRTALTHYLDITNPLHTNVLFELSQYAS-DSEERERMCRMSSSSSEGKALYHSWVVESERNILAVLEDLPSLNPPVDYLCELLPRLQARYYSIAS--SAKVHPTSIHICAVVLDYTTKTGRVFKGVATNWLKNKVKTEGGPWPTVPIYVRKSQ--FRLPFKASNPVIMIGPGTGIAPFMGFLQERAWQKQQGNETGETVLYFGCRHKNEDFIYQEELEEFKKAGVLTQLHVAFSRDQ------EHK--------VYVQHLLKQNKEHLWKLIHSNNAHIYVCGDARNMARDVHEAFHEI--AEEAGGLTHTQAVDYFQRLMTKGRYSQDVW 633

[Close]

BLAST of methionine synthase reductase vs. Ensembl Cavefish
Match: porb (NADPH--cytochrome P450 reductase-like [Source:NCBI gene;Acc:103023972])

HSP 1 Score: 182.185 bits (461), Expect = 3.033e-48
Identity = 171/673 (25.41%), Postives = 291/673 (43.24%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDY-IKHINI----FELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNE----DSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQ-PLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV---SFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVL--LGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            K   + YGSQTG  +  A  L    + Y +K +      +++ ++ +  EI   + AI   +T G+GD  DNA  F   ++      L    +TV  LG+  Y ++    K +D+ L   GA+R +   M DD   LE     W +  +     +C    ++     S   +                   + +D++             +N IY  E     S  N   P  +  P  S  +         + +  NK   + +    +++  +K +++ GD V + P N  + V+ +   L V   + + V+ L  L+   N++   P           + ++ L    D+   P + V   +       K  E  R +   S EG++ Y   + ++S  +L +L   PS + PI  L E+LPRL+ R YS+     V   S     V +   QT   R   GV T+W++      N     +P+Y+RK+   F +    S P I+IGPGTG+APF+GF+Q    LK + + +G   ++FGCR++  DF+++++LE F    +LT L V FSRD       E+K         YVQH L ++ + +   +   NA +++CGD+  M++DV   +  +   LG      T   A  +I  +  +  Y +DVW
Sbjct:   77 KNIVVFYGSQTGTGEEFANRLSKDAQRYGMKGMAADPEEYDMSELSRLKEIDN-SLAIFCMATYGEGDPTDNAQDFYDWLQESDAD-LDGVNFTVFALGNKTYEHYNAMGKYVDKRLSELGAKRIFDLGMGDDDGNLEEDFVSWREQFWPA---VCEHFGVEATGEESSIRQYELK---------------VHEDLN-------------MNKIYTGELGRLKSFENQKPPFDSKNPFLSPVT---------VNRKLNKGGDRHLMHLELDITGSKIRYESGDHVAVYPTNDSNIVNKLGEVLGV---DLDTVISLNNLDEESNKKHPFP--------CPTTYRTALTHYLDVTSCPRTNVLYELAQYASDPKDQENMRKMASSSPEGKALYQTWVLDSSRNILAILEDLPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSIHICAV-VVEYQTKTGRTNKGVATNWLKNKVPTDNGHKATVPMYIRKSQ--FRLPFKSSNPVIMIGPGTGIAPFMGFIQERAWLKQQGKEVGETVMYFGCRHKNEDFLYQEELEAFEKEEVLTQLNVAFSRDQ------EKK--------VYVQHLLKNNKEEVWRQIHKDNAHIYICGDARNMARDVQSVFYEIAEELGG----MTHTQAVDYIKKLMTKGRYSQDVW 675

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BLAST of methionine synthase reductase vs. Ensembl Cavefish
Match: NOS2 (nitric oxide synthase, inducible-like [Source:NCBI gene;Acc:103026958])

HSP 1 Score: 146.362 bits (368), Expect = 1.082e-35
Identity = 171/675 (25.33%), Postives = 292/675 (43.26%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLK----DYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYL-SNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLG-DHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAK--WKWKPGDSVGILPFNAESEVDSILSRL-SVPETEKNCVVXXXXXXXXX--XXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLC---DLESVSFAFSKVDIAPIQTFRKRPL-TGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQ--YFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCK-YVQHCLLHHSKILSDLL---VNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ILY ++TG++++ A+ L + L       +  +  +   D+EK          I++ ST G+G++P N   F +  K+   K L +N +Y V GLG   Y  FC  +  +D  L   GA+        D+  G +     W    +   K +C E  I+G                      +L G + L    D + + V    S  L+ I     ++S  H    T  PM          +++    + +  + +S     + V  AK    + PGD VG+ P N+   V  IL  + SVP T ++  +  +         +  ++P           SL   L +L D+  P S+  LR +S+    K  +++RLL L S        K  R+ +   L++L  FPS ++    +L  LP +KPR YSL    DL       +   +       K PL  GVC++W+  +   H      +P ++  + +GF +  +P+ P ILIG G+G+APF  F Q  Y +K K   +   P+ L FGCR+ + D ++K++      +G L  +   +SR              QP + K YVQ  L    K LS+ +   + +   V+VCG  + M+++V  T  +++ G  +      +A  ++  ++ +K Y ED++
Sbjct:  488 ILYATETGKSQTFAKKLKSMLSCAFNPRLLCMEDYRFGDLEKE------RLLIVVTSTFGNGESPGNGETFQK--KLMGKKQLKNNLRYCVFGLGSRMYPQFCAFAHAVDDKLAELGAKCVTPIGEGDELNGQDEAFSAWACTAF---KAVCKEFGIEG----------------------QLSGAERLTDSWDPQKIRVQP-DSSTLDCI----SALSALHSK--TVFPM----------KLKRRKNLQSSQSRRSTILVELEVHGAKDVLNYAPGDHVGVFPENSPELVTGILKHIPSVPPTNQSLHLEYQANSGGVGWQKDERLP---------ACSLTQALTYLLDITTPPSQGLLRKLSQVS-KKEDDRQRLLALASDFKSYSEWKEFRKPNF--LEVLEEFPSLEVSAAFVLSQLPLMKPRLYSLSSSPDLHPNELHLTVSVVNYRTQDGKGPLHHGVCSTWLNTLKDGHT-----VPCFIHGS-SGFHLPPDPTTPTILIGAGSGIAPFRSFWQQRYHDKEKKGLKE-SPMMLVFGCRDSDTDHLYKEETYEMRENGTLKSITPAYSR--------------QPGHPKVYVQDVL---KKQLSEEVWQALQKAGHVYVCGGMN-MAREVAHTIQDIVAG--QLGVPFSEAGGYLERLKAEKRYHEDIF 1073

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BLAST of methionine synthase reductase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004550.1 (pep scaffold:Pmarinus_7.0:GL501143:124546:139236:-1 gene:ENSPMAG00000004118.1 transcript:ENSPMAT00000004550.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 334.339 bits (856), Expect = 1.154e-104
Identity = 230/707 (32.53%), Postives = 357/707 (50.50%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVE-----------KSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKEL---LGDHLAKDMDG--------------------KNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKV--DIAPIQTFRKRPLT--GVCTSWM-------EKMAKFHNEQIWKIPIYLRKNMN-------GFTVCENPSIPHILIGPGTGVAPFIGFLQYFE-KLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +LYG++ G AK+IA++L A+ + +    ++  L               ++ E H+LN                  S    +I +Y+   +S F     GLGDTNY+NFCNC +T+D+ L   GA+RFY++  ADDAVG E+V EPW++GL+E     C +    G   +           +  + + +    + +   K +D                       L VP+LP P+L + ++   S        +    +P++ SE+    V    ++T   A+K+     ++V +A +   PGD++G+L  N E+EVD++L RL + + + +C + L    N   R +KVP+ +        SL+SIL    ++R    K  +R ++E+     AE+RRLLEL SR+G + YT  LR+ S+ +  LL+ FPSC+ P   L+E LPRL+PRAYS+     V+   + V  ++        RP    GVCT W+       E         +   P+   K ++       GF + E+ S+P I+IGPGTGVAPF+GFLQ+ E K       +G  WLFFGCR+ +RDF++++QLE F   G LTHL V FSRD P  S          P  +YVQH L  H   +  LL+ + AR++VCGD+  M++DV ET  ++++   E    K +A   I G++ Q  YL+DVW
Sbjct:    6 LLYGTEIGTAKAIAQDLCAQAERFGLDADLHCLSKTHDESGSLTWIPSETKEKHRLN------------------SCLKSVIVVYRELTVSCFFSA--GLGDTNYTNFCNCGRTMDRRLAELGAQRFYQTGHADDAVGTELVAEPWVEGLWEALVSECKQ-EGGGTSRVGERVADVSPPRERDQEHGDAGKQISESTEKTLDQTQPEKPLVPSLTVSVPPLSEATLQVPSLPEPYLQLQFD--PSRPGVFVERMGHHFIPAA-SEVCEVAVSGWKQLTRADAVKTALELQLDVSDAPFALCPGDALGVLCPNGEAEVDALLRRLGL-DGQADCTLELRAKPNARGRASKVPDFI----PAGSSLRSILTHGLEIRALPKKAMVRALAEHT-EDEAERRRLLELSSRQGSADYTHLLRDASLGLAALLHAFPSCRPPASLLIEHLPRLQPRAYSIASSPLVTPGAAHVVFNVVEFAAGPGRPQAQRGVCTGWLAEVVVGPEAKGNSRPSNLSGAPLADPKLLSPKAAKSTGFRLPEDASVPIIMIGPGTGVAPFVGFLQHREHKAGGGTAALGESWLFFGCRHRDRDFLYREQLEGFVARGTLTHLRVAFSRDEPAGSEVASPGGVAHP--RYVQHSLGQHRADVMRLLLQEGARLYVCGDAKNMARDVQETLVDMVV--EEMGVAKLEAMRVIGGLKEQGRYLQDVW 678

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BLAST of methionine synthase reductase vs. Ensembl Sea Lamprey
Match: porb (P450 (cytochrome) oxidoreductase b [Source:ZFIN;Acc:ZDB-GENE-030131-5767])

HSP 1 Score: 159.844 bits (403), Expect = 2.722e-41
Identity = 120/402 (29.85%), Postives = 194/402 (48.26%), Query Frame = 2

Query:  845 INVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCP-MKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV---SFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +++  +K +++ GD V + P N  + V+  L+RL   + +    +     E+ +      P           + ++ LL   D+  P     L  +++Y    K  E  R +   + E ++ Y   + +    +L +L   PS + PI  L E+LPRL+ R YS+     V   S     V +   +T   R   GV TSW++      N     +P Y+RK+   F +   PS P I+IGPGTG+APF+GF+Q  E  K + + +G   L+FGCRN   DFI++++LE F   G+LT L V FSRD       E+K         YVQH +  + + +  LL   NA ++VCGD+  M++DV    S V+  +     T++ A  F+  ++ +  Y  DVW
Sbjct:  311 LDISGSKMRYEAGDHVAVFPTNDSALVEE-LARLLGADLDTVFSLNNLDEESNKKHPFPCP----------TTYRTALLHYLDITNPPRTNVLYELAQYASDPKEQEFLRRMASSAVECKTQYQSWVLDERRHILAILQDLPSVKPPIDHLCELLPRLQARYYSIASSAKVFPDSIHICAV-LVEYKTRLGRTNRGVATSWLQGRCPSQNGHKPTVPAYVRKSQ--FRLPYKPSSPIIMIGPGTGLAPFLGFIQEREWQKQQGKEVGETVLYFGCRNRSTDFIYEEELEAFKERGVLTQLHVAFSRDQ------EEK--------VYVQHLITKNKENIWQLL-QSNAHIYVCGDAKNMARDVQAAISEVV--SECGGLTQQQALDFVKKLQTKGRYSSDVW 681

HSP 2 Score: 55.4546 bits (132), Expect = 4.169e-8
Identity = 30/84 (35.71%), Postives = 44/84 (52.38%), Query Frame = 2

Query:  212 NFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLE 463
            + A+   +T G+GD  DNA +F  L++    + L+  KY V GLG+  Y +F    K +D+ LE  GA R +     DD   LE
Sbjct:  137 SLAVFCMATYGEGDPTDNAQEFYDLLQEGSLE-LAGVKYAVFGLGNKTYEHFNAMGKYLDKRLEELGAERIFELGSGDDDATLE 219

[Close]

BLAST of methionine synthase reductase vs. Ensembl Yeast
Match: TAH18 (Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs [Source:SGD;Acc:S000006252])

HSP 1 Score: 137.887 bits (346), Expect = 1.980e-34
Identity = 175/702 (24.93%), Postives = 298/702 (42.45%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDN--ASKFLRLIKIYQ--------PKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQ-ILESKGARRFYRSDMADD----------AVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPAL-PSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATI-NVPNAKWKWKPGDSVGILPFNAESEVDSILSR----LSVPETEKNCVVXXXXXXXXXXXXAKVPEHL----IVRENGKMSLKSILLWLCDLRQ-PLSKVGLRI---MSEYCPMKSAEQR------RLLELCS-REGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVL--LGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            K   ILYGS+TG A   A  L  +L  +        + D +   +I K  +  IICSTTG G+ P N  A K  R +  +            L++ +  +LGLGD++Y  F    + + Q I+   GA   +    ADD           +G+E V        +E  K + S                             LL  +  + ++G+ +    L P  +L      + S  + +E   ++  +   D  L +G V    +IT++   + V +    NV   +  ++PGD+V I P N + +V   L+     L + +   N               + VP  L    +VR    M+L+++L + CD    P +   L+I    ++   M+  +++      +L +  + ++ Q  Y  C R     +L++L  F S ++P   +L+ LP +KPR YS+            V I   +T  ++   G+CT+++ ++ +   EQI     Y  +N N     E  + P IL+GPG G+AP +  ++  E  K+       I L FGCR +++D+I+K  LE +   G +  L   FSRD   +           P  KYVQ  L    + +++L+VN++A  F+CG S  M   V  T+  +L   GN    +T   A  ++  M     Y+++ W
Sbjct:    5 KKIVILYGSETGNAHDFATILSHRLHRWHFSHTFCSIGDYDPQ-DILKCRYLFIICSTTGQGELPRNVNALKGERPVTFWSFLKRKNLPSNLLNHIQTAMLGLGDSSYPKFNYGIRKLHQRIVTQLGANELFDRLEADDQAMAGSNKGTGLGIESVY-------FEYEKKVLSF----------------------------LLSKYPNRKVNGQIIKREELDPEVYLEPASYLQLSDEHANEKFTSTKVIFEGDESLKVGRVNINKRITSEGHFQDVRQFKFSNVDKIQENYEPGDTVTIYPCNTDEDVSRFLANQSHWLEIADKPLNFT-------------SGVPNDLKDGGLVRP---MTLRNLLKYHCDFMSIPRTSFFLKIWTFATDVTKMERGQEQLNDQREKLRQFATDQDMQDLYDYCNR-PRRSILEVLEDFISVKLPWKYVLDYLPIIKPRYYSISSGPGDPNIELTVAIVKYKTILRKIRRGICTNYIARLQE--GEQIR----YKLQN-NHIIKKEFLNKPMILVGPGVGLAPLLSVVKA-EISKD-------IKLLFGCRYKDKDYIYKDMLEDWFRKGKIA-LHSSFSRDEENS-----------PGVKYVQDYLWRLGEEITNLVVNKDAVFFLCGSSGKMPIQVRLTFIEMLKKWGNFSDEET---AKKYLKEMEKSDRYIQETW 623

[Close]

BLAST of methionine synthase reductase vs. Ensembl Yeast
Match: NCP1 (NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p [Source:SGD;Acc:S000001084])

HSP 1 Score: 132.88 bits (333), Expect = 1.161e-32
Identity = 175/721 (24.27%), Postives = 299/721 (41.47%), Query Frame = 2

Query:   38 IMHLLCDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFEL-DDVEKSFEIHKLN----FAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGL-EIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSIS----NFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSV-PETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQ----IPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTF------RKRPLTGVCTSWMEKMAKFHNE---------------------QIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQ----YFEKLKNENQNI--GPIWLFFGCRNEERDFIFKKQLEHFAN--SGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCK--YVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLG--NHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            I  ++ +  K   +LY SQTG A+  A+      K+ +   N+  +  DVE +++   LN       I  ST G+GD PD A  F   I   +   LSN +Y + GLG++ Y  F   +K  ++ L + GA R  +   ADD  G  +     W D + E+ KD   E+ +D            + E K    ++  + + +   M     +   LPS  LN    N D I     +  +P I   P+  S         +++    ++  I S      ++  +  K+  GD + + P N   +V+  LS  ++ PET               +   KVP           ++ + +    ++  P+S+     + ++ P  +A+ +  L L S++   F  + +      + D L +         +P+  L+E +P++ PR YS+            V  + ++ F         P+ GV T+ +  +    N                        +K+P+++R++   F +  NPS P I+IGPGTGVAPF GF++    + E  K    N+  G   LF+G RN + DF+++ +   +A    G    + V  SR                PN K  YVQ  L  +   + + ++N  A ++VCGD+ GM+K V    S  L+G  +  K  T  +A   I  ++    Y EDVW
Sbjct:   50 IAQVVTENNKNYLVLYASQTGTAEDYAKKFS---KELVAKFNLNVMCADVE-NYDFESLNDVPVIVSIFISTYGEGDFPDGAVNFEDFICNAEAGALSNLRYNMFGLGNSTYEFFNGAAKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKD---ELHLD------------EQEAKFTSQFQYTVLNEITDSMSLGEPSAHYLPSHQLN---RNADGIQLGPFDLSQPYIA--PIVKS---------RELFSSNDRNCIHS----EFDLSGSNIKYSTGDHLAVWPSNPLEKVEQFLSIFNLDPET--------IFDLKPLDPTVKVPFPT------PTTIGAAIKHYLEITGPVSRQLFSSLIQFAP--NADVKEKLTLLSKDKDQFAVE-ITSKYFNIADALKYLSDGAKWDTVPMQFLVESVPQMTPRYYSISSSSLSEKQTVHV-TSIVENFPNPELPDAPPVVGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGPRKLFANYKLPVHVRRS--NFRLPSNPSTPVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNNVSLGKHILFYGSRNTD-DFLYQDEWPEYAKKLDGSF-EMVVAHSR---------------LPNTKKVYVQDKLKDYEDQVFE-MINNGAFIYVCGDAKGMAKGV----STALVGILSRGKSITTDEATELIKMLKTSGRYQEDVW 691

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BLAST of methionine synthase reductase vs. Ensembl Yeast
Match: MET10 (Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide [Source:SGD;Acc:S000001926])

HSP 1 Score: 77.0258 bits (188), Expect = 6.266e-15
Identity = 65/297 (21.89%), Postives = 133/297 (44.78%), Query Frame = 2

Query: 1160 EQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQ--TFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKL--KNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            E+++L +L +  G     +          D+   FPS +  +  L+ ++  LK R YS+   + V      + I  +     + R   G  + ++  +A      +   P  ++       +  +P  P I+ G GTG+APF   ++  EKL  K +   IG ++L+ G R++  ++++ +  E + ++GI+TH+   FSRD P      QK         Y+Q  +  +   L   +++     ++CG +  +  D+ +   ++L  + E+   K D D+ I  ++    Y+ +V+
Sbjct:  763 EKKKLEDLVTPAGAVDLKRFQDVEYYTYADIFELFPSVRPSLEELVTIIEPLKRREYSIASSQKVHPNEVHLLIVVVDWVDNKGRKRYGQASKYISDLAVGSELVVSVKPSVMK-------LPPSPKQPVIMSGLGTGLAPFKAIVE--EKLWQKQQGYEIGEVFLYLGSRHKREEYLYGELWEAYKDAGIITHIGAAFSRDQP------QK--------IYIQDRIKENLDELKTAMIDNKGSFYLCGPTWPV-PDITQALQDILAKDAEERGIKVDLDAAIEELKEASRYILEVY 1035

[Close]

BLAST of methionine synthase reductase vs. Ensembl Nematostella
Match: EDO40246 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7T0])

HSP 1 Score: 214.927 bits (546), Expect = 1.169e-60
Identity = 158/497 (31.79%), Postives = 243/497 (48.89%), Query Frame = 2

Query:  656 VPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRL---SVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCD--LE---SVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMA---------------KFHNEQIW-----KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEK---LKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVL-----LGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +  L  P  +I+    D  +  H+        P + S + M  +    ++T   A+K     T+++  + W+++ G+S  I   N E EVD+I+ RL   S+ +   +  V     +   +    +P+   ++E+        LL   D+R    K  LR + E+    + EQRRL ELCS++G   Y + +RE S+ +L+LL  FPSC  P  RLLE LPRL PR YS+    LE    ++F F+ V     +  RK    GVCTSW+E +                K     I      ++P+  R N + F +  +  IP I+IGPGTGVAPFIGFL +  K   L  +    G +WLFFGCR+ E+DF+++K+LE F  +G L+ L   FSRD        Q         +YVQ  L      ++DL++N  A V+VCGD+  M+ +V E +  ++     +G  E I+        +T +R ++ Y EDVW
Sbjct:  146 IDGLWGPLKDILGKTPDFSTVPHQ---AGASFPGAASPITMATIVGARRLTADDAMKKALEITLDISQSGWEYEAGNSFNIYCPNDEGEVDAIIERLGLTSMAQVPYDIQVMSGTKKKTASIPNYIPQPYTIKES--------LLTCLDIRMVPRKAFLRTLVEFT-HDNNEQRRLQELCSKQGADEYCRFVREPSLSLLELLTAFPSCFPPFERLLEHLPRLSPRPYSISSSPLEKPGQLNFVFNVVKFGEFEDIRKS-RKGVCTSWLEGLTGSMITEEGNKANGILKISELSILSSPYVQVPVSARSNSD-FKLPPDSRIPVIMIGPGTGVAPFIGFLHHRRKQMELAEDLTGFGEMWLFFGCRHREKDFLYQKELESFVETGTLSRLFTSFSRD--------QGFTVSLSTPRYVQDNLKLQGDKIADLVLNDGAVVYVCGDAKNMASNVFECFCEIIEKHLCVGKMEAIKE-------MTRLRKERKYREDVW 613

HSP 2 Score: 134.42 bits (337), Expect = 6.967e-33
Identity = 68/153 (44.44%), Postives = 96/153 (62.75%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIK--IYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIP 529
            ILY SQTGQAK+IA+ ++ K      +  +F L   EK F + K +  + + STTG+GD PD   KF R +K       +L + +Y +L LGD+NY+NFC   K +D+ L   GA++FY +  ADDAVGLE+VVEPW+DGL+   KD+  + P
Sbjct:    9 ILYASQTGQAKAIADEIHEKSASNGLNSKLFCLSLTEKKFMLEKESAVVFVVSTTGEGDPPDTMLKFFRRLKKKTLPGNHLKDLQYGLLALGDSNYTNFCVNGKNLDRRLNELGAKKFYDTGHADDAVGLELVVEPWIDGLWGPLKDILGKTP 161

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BLAST of methionine synthase reductase vs. Ensembl Nematostella
Match: EDO30877 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZI6])

HSP 1 Score: 176.792 bits (447), Expect = 2.628e-47
Identity = 163/668 (24.40%), Postives = 302/668 (45.21%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDA--VGLEIVVEPWLDGLYEIAKDMCSEIPID-GFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQS-FYTKCLRETSMPVLDLLNWFP--SCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPI--QTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            K   +LYGSQTG A+ +AE +  + +       +  LDD   + ++ K +  + +C+TTG GD PDN  KF R I  +      L    ++VLGLGD++Y  F   +K +++ L   GA       +ADD   +G + VV+PWL  L+E    + +  PI  G + +S  E+           YK +  D  A++   +     +  +PF   + +N+                                ++T     + V    +++  +   + PGD V + P N     +  +S L + + +KN  ++    +        VP  L        S++ ++    D++    +    ++S + P +  E+ +L +  S EGQ   Y+ C R+     L++L  FP  S  +P   LL+++P ++PRA+S+   +       ++ +A +  QT   +P  G+C++W+  +         ++P+++++      +  + ++P ++IGPGTGVAPF  F++  E+L   ++    + LFFG RN+  DF F+ Q +  + +G L+ +   FSRD      D++          YVQH +   S ++ DL+ N  A  ++ G+S  M  DV E    V         ++ +A++    +   + Y  + W
Sbjct:    8 KRLTVLYGSQTGTAQEVAERIGREGRRRHISARVLALDDYNVA-DLIKEDLVVFVCATTGQGDEPDNMKKFWRFIMRRNLPAHSLQQLSFSVLGLGDSSYPKFNFIAKKLNKRLLQLGASVLQPVGLADDQHDLGPDAVVDPWLKELWE---KVFAVYPIPPGLEIISADERPPA-------RYKIIYTDSPAEESSLEFGLPASQQAPFFATLISND--------------------------------RVTASNHWQDVRLVKLDISGSGISYSPGDVVMVQPSNLSDTAEEFMSFLHL-DPDKNFTLQQTNPDI------PVPRRL----PRPCSIRFLVEHYLDIQGVPRRYFFELLSHFTPSE-LEKEKLQDFASAEGQEDLYSYCYRQKRS-TLEVLQDFPQASANLPFEYLLDLIPAIQPRAFSIASAQKAHPDEIEILMAVVKYQTKISKPRRGLCSTWLSSLPSRS-----RVPVWVKRGTISLPL--DHTVPLLMIGPGTGVAPFRSFIE--ERLVPVHEGSKCV-LFFGSRNKNADFFFENQWKELSETGCLS-VFTAFSRDQ-----DDK---------IYVQHRIREQSSLIWDLINNHRAICYLAGNSKRMPIDVKEALIEVFCKGE---MSESEAEALFAELERTRRYQAETW 591

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BLAST of methionine synthase reductase vs. Ensembl Nematostella
Match: EDO39434 (NADPH--cytochrome P450 reductase [Source:UniProtKB/TrEMBL;Acc:A7SA55])

HSP 1 Score: 141.739 bits (356), Expect = 4.243e-35
Identity = 94/332 (28.31%), Postives = 164/332 (49.40%), Query Frame = 2

Query: 1061 SLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCS---REGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQ--TFRKRPLTGVCTSWME-KMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            + ++ L+   D+   +    LR ++EY   +  E++  L   S    E +  Y + + +    ++ +L   PS + P+  +LE+LPRL+ R YS+        +   V    ++  T   R   GV T+W+  K+ K      W +PI++R+    F +   P  P I+IGPGTG+APF GF+Q    L  + + +G   LFFGCR++ +D+I++ +LE +A  G ++ L V FSRD                  +YV H +  ++  + +LL +Q A ++VCGD+  M++DV    + +     +   T   AD ++  +  +  Y  DVW
Sbjct:  363 TYRTALMHYVDITSTVKTHVLRELAEYA--RDHEEKEFLMAISDSTEEAKKKYNEWVIQPHRHIVAVLEDMPSLKPPLDHILELLPRLQCRYYSISSSPKAHPSHIHVTAVVVKWTTKTGRVQNGVATTWLATKIPKG-----W-VPIFVRRTT--FRLPFKPVTPVIMIGPGTGLAPFRGFIQDRNALVKQGKRVGDTVLFFGCRHKAQDYIYENELEDYAADGTISRLHVAFSRDQDKK--------------RYVTHLMRENTDEIWNLL-DQGAHIYVCGDARNMARDVHTIVTEI--AREKGGMTDSQADDYVKKLSAKGRYATDVW 667

HSP 2 Score: 67.0106 bits (162), Expect = 1.863e-11
Identity = 42/137 (30.66%), Postives = 69/137 (50.36%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIF--ELDDVEKSFEIHKLN--FAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLE 463
            K   I YGSQTG A+  A  L    + Y     +F  E +D+E+   + +++  FAI + +T G+GD  DNA +F   ++  +   L    + V GLG+  Y ++ +  + +D+ LE  G  R Y+    DD   +E
Sbjct:   70 KPLAIFYGSQTGTAEEFASRLAKDAQRYGIKAMVFDPEENDMEELTRMGEIDNSFAIFVMATYGEGDPTDNAQEFYEWLQNDRDD-LDCLNFAVFGLGNKTYEHYNSMGRYVDKRLEELGGYRIYQRGEGDDDGNIE 205

[Close]

BLAST of methionine synthase reductase vs. Ensembl Nematostella
Match: EDO39440 (Nitric oxide synthase [Source:UniProtKB/TrEMBL;Acc:A7SA75])

HSP 1 Score: 124.79 bits (312), Expect = 2.665e-29
Identity = 154/678 (22.71%), Postives = 289/678 (42.63%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNA--SKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINV-PNAKWKWKPGDSVGILPFNAESEVDSILSRL-SVPETEKNCVVXXXXXXXXXXXXAKVPEHLIV-RENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKR----PLT-GVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEK---------LKNENQNIGPIW----LFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCK-YVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            ILY ++TG+++S A  L A L  +     +  +D+     E+      +I+ ST G+GD P+N   S    L    Q + + +    + GLG   Y NFC  ++++D+I++  GA + ++    D+  G E   + W   +++ A   C    +    N++                          + D    T+ +  SP      + ++ + +  + + +    P     +V  +V+ + K+ +  + +S     ++  P A++ + PGD + + P N    V S++ RL   P+ ++   + +    + +    K  +   V R     +++       D+    +   L+ ++      + + R  LE   + G + Y     E    ++++L  FPS  +    LL  LP L+PR YS+   +  S     + +A +Q + KR    P+  GVC++W   +          +P ++RK  + F + ++ S+P I++GPGTG+APF  F Q  +           K  +   G  W    L+FGCR    D I++++ +     G L  +    SR              +P + K YVQ  L   +  + D LV Q A ++ CGD S M+ DV  T   +L        T+++A  FI  ++    Y ED++
Sbjct:  485 ILYATETGKSESYARML-ADLFLHAFDPKVMRMDEYPHP-EMENEQLILIVTSTFGNGDPPENGEVSTINPLDSASQQRIIED---QMFGLGSRAYPNFCAFARSLDKIIQELGAEQIHKCGEGDELAGQEESFKTWAKQVFKAA---CDTFCVGEMVNVA--------------------------EADESLNTLSSGWSPGKYRFTSVKEELQDVCKSIASVNNKP-----IVGAKVKSVKKLQSADSSRSTILLKLDTSPAAEFHYNPGDHLSVFPCNRRELVQSLIDRLCEAPDPDQPIKLEVCQETSGKRPFGKTKKWTPVDRLPTPTTVREAFSRFIDIAGTPTPQILKSLASLA--TNPKDREALETLGK-GDNHYDDWKYEKQSNIVEVLEEFPSVNVEAEMLLTQLPLLQPRFYSISSSQDFSPNEVHLTVAVVQ-YNKREGKGPVHYGVCSTWFNGLKPGD-----IVPCFVRK-AHSFHLPDDGSLPIIMVGPGTGIAPFRSFWQQRQYDIVKKPSPVPKPRDAAPGSGWGDMVLYFGCRCSTLDDIYQEETKTAHQDGALAAVRTALSR--------------EPGHVKQYVQDLLKEDADAIIDKLVGQGAHLYTCGDVS-MAADVCRTIQKLL--EEYAAMTQQEAQEFIDNLKSSGRYHEDIF 1096

[Close]

BLAST of methionine synthase reductase vs. Ensembl Nematostella
Match: EDO28992 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T4X1])

HSP 1 Score: 68.5514 bits (166), Expect = 4.141e-12
Identity = 43/148 (29.05%), Postives = 73/148 (49.32%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIF--ELDDVEKSFEIHKLN--FAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLY 496
            K   I YGSQTG A+  A  L    + Y     +F  E +D+E+   + +++  FAI + +T G+GD  DNA +F   ++  +   L +  + V GLG+  Y ++ +  + +D+ LE  G  R Y+    DD   +E     W +  +
Sbjct:    2 KPLAIFYGSQTGTAEEFASRLAKDAQRYGIKAMVFDPEENDMEELTRMGEIDNSFAIFVMATYGEGDPTDNAQEFYEWLQNDRDD-LDSLNFAVFGLGNKTYEHYNSMGRYVDKRLEELGGNRIYQRGEGDDDGNIEEDFVRWREEFW 148

[Close]

BLAST of methionine synthase reductase vs. Ensembl Medaka
Match: mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:NCBI gene;Acc:101167253])

HSP 1 Score: 218.009 bits (554), Expect = 1.629e-60
Identity = 158/487 (32.44%), Postives = 249/487 (51.13%), Query Frame = 2

Query:  647 NLTVPALPSPFLNIIYNNEDSISNFHEPLI-TSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPN-AKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYS-----LCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIW--------------KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +L VPALP PFL++     D+      PL  T   +P S + L          ++   ++K+     +++       ++PGDS+ +L  N   EVD +L RL + +  ++  V + L ++ + + A VP H+       +SL  +  W  ++R    K  LR + EY      ++RRL ELCS++G + Y   +R+ S+ V++LL  F SC  P+  L+E LP+L+PR YS     L     + F FS V++ P    R     G+CT W+  +   H   ++               I + LR + + F      S+P I++GPGTGVAPFIGFLQ  E+ +  N     G  WLFFGCR+   D++F+++LE F  SG L+HL VCFSRD                N +YVQH LL + + ++D+L+ Q+   +VCGD+  M+KDV ET   ++    E    + +A   +  +R +K YL+D+W
Sbjct:  266 SLNVPALPPPFLDVTLVEVDAPEQNVGPLKETFHEVPISKAVL----------LSRGDSVKTALLLELDISTCPALTYQPGDSLDVLCPNRAEEVDYMLCRLGL-KDRRDHRVHVALRKDTKKKGAHVPPHI----PQNVSLLFLFTWCLEIRSVPKKAFLRALVEYA-ADGTQKRRLQELCSKQGAADYNLHVRDASLSVVELLTAFSSCSPPLSLLIEHLPKLQPRPYSAASSCLRHPGKLHFVFSVVEL-PACFGRPAGRRGLCTGWLFDL--IHPGIVFPGKTESSSSPAPAKAIHVSLRPSCS-FRPPSEQSVPFIMVGPGTGVAPFIGFLQQREEARKRNPEAVFGETWLFFGCRHRNGDYLFREELEGFVASGTLSHLKVCFSRDGREAEEAVASAA----NPRYVQHNLLLYRQQVADILLRQSGCFYVCGDAKNMAKDVNETLMEII--KTELHVDQLEAMKKLAELREKKRYLQDIW 726

HSP 2 Score: 142.895 bits (359), Expect = 6.315e-35
Identity = 70/159 (44.03%), Postives = 105/159 (66.04%), Query Frame = 2

Query:   53 CDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQ-PKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEI 526
            C+      +LYGSQ GQA+SIAE +  + +D+     +  L+  EK     ++   + + STTGDG+ PDNA +F++ I   Q P +  +  YT+L LGDTNY+NFCNC KTI++ L++ GAR+FY +  ADD VGLE+VV+PWL+GL++  K+  S++
Sbjct:    3 CETKSRFVVLYGSQKGQAQSIAEGIAEEAEDHGLVAELSCLNQDEKYNLEKEIAPVVFVVSTTGDGEPPDNALQFVKRINKNQSPDHYKHLSYTLLALGDTNYANFCNCGKTIERRLQALGARQFYPAGFADDGVGLELVVDPWLEGLWKAVKEASSKM 161

[Close]

BLAST of methionine synthase reductase vs. Ensembl Medaka
Match: mtrr (5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:NCBI gene;Acc:101167253])

HSP 1 Score: 218.394 bits (555), Expect = 2.299e-60
Identity = 158/487 (32.44%), Postives = 249/487 (51.13%), Query Frame = 2

Query:  647 NLTVPALPSPFLNIIYNNEDSISNFHEPLI-TSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNA-KWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYS-----LCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIW--------------KIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQN--IGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            +L VPALP PFL++     D+      PL  T   +P S + L          ++   ++K+     +++       ++PGDS+ +L  N   EVD +L RL + +  ++  V + L ++ + + A VP H+       +SL  +  W  ++R    K  LR + EY      ++RRL ELCS++G + Y   +R+ S+ V++LL  F SC  P+  L+E LP+L+PR YS     L     + F FS V++ P    R     G+CT W+  +   H   ++               I + LR + + F      S+P I++GPGTGVAPFIGFLQ  E+ +  N     G  WLFFGCR+   D++F+++LE F  SG L+HL VCFSRD                N +YVQH LL + + ++D+L+ Q+   +VCGD+  M+KDV ET   ++    E    + +A   +  +R +K YL+D+W
Sbjct:  294 SLNVPALPPPFLDVTLVEVDAPEQNVGPLKETFHEVPISKAVL----------LSRGDSVKTALLLELDISTCPALTYQPGDSLDVLCPNRAEEVDYMLCRLGLKD-RRDHRVHVALRKDTKKKGAHVPPHI----PQNVSLLFLFTWCLEIRSVPKKAFLRALVEYA-ADGTQKRRLQELCSKQGAADYNLHVRDASLSVVELLTAFSSCSPPLSLLIEHLPKLQPRPYSAASSCLRHPGKLHFVFSVVEL-PACFGRPAGRRGLCTGWLFDL--IHPGIVFPGKTESSSSPAPAKAIHVSLRPSCS-FRPPSEQSVPFIMVGPGTGVAPFIGFLQQREEARKRNPEAVFGETWLFFGCRHRNGDYLFREELEGFVASGTLSHLKVCFSRDGREAEEAVASAA----NPRYVQHNLLLYRQQVADILLRQSGCFYVCGDAKNMAKDVNETLMEII--KTELHVDQLEAMKKLAELREKKRYLQDIW 754

HSP 2 Score: 142.895 bits (359), Expect = 7.129e-35
Identity = 71/167 (42.51%), Postives = 107/167 (64.07%), Query Frame = 2

Query:   29 FVYIMHLLCDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQ-PKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEI 526
            F     + C+      +LYGSQ GQA+SIAE +  + +D+     +  L+  EK     ++   + + STTGDG+ PDNA +F++ I   Q P +  +  YT+L LGDTNY+NFCNC KTI++ L++ GAR+FY +  ADD VGLE+VV+PWL+GL++  K+  S++
Sbjct:   23 FSLFCSMPCETKSRFVVLYGSQKGQAQSIAEGIAEEAEDHGLVAELSCLNQDEKYNLEKEIAPVVFVVSTTGDGEPPDNALQFVKRINKNQSPDHYKHLSYTLLALGDTNYANFCNCGKTIERRLQALGARQFYPAGFADDGVGLELVVDPWLEGLWKAVKEASSKM 189

[Close]

BLAST of methionine synthase reductase vs. Ensembl Medaka
Match: POR (NADPH--cytochrome P450 reductase [Source:NCBI gene;Acc:101166486])

HSP 1 Score: 194.126 bits (492), Expect = 1.869e-52
Identity = 179/670 (26.72%), Postives = 298/670 (44.48%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDY-IKHINI----FELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQN-LSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPM-KSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV---SFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQ--TKRDADSFITGMRVQKLYLEDVW 2038
            K   + YGSQTG A+  A  L    + Y +K +      + + ++ +  EI K + AI   +T G+GD  DNA  F   ++    + LS   YTV  LG+  Y ++    K +D+ LE  GA+R +   + DD   LE     W +  +     +C    ++   + LSI +   K+      N K   G+       G+  +      PF        D+ + F  P+  +  +  +    +M    DIT                    +K +++ GD V + P N  + V+ +   L V   + + V+ L  L+   N++   P           + ++ L    D+  P     L  +++Y    K  E  R +   S EG++ Y   + ++   +L +L   PS + P+  L E+LPRL+ R YS+     V   S     V +    T   R   GV T+W++   K  N     +P+++RK+   F +    + P I+IGPGTG+APF+GF+Q    LK + + +G   L+FGCR++  D+I++++LE    SG+LT L V FSRD                   YVQH L  + + +  L+   NA ++VCGD+  M+KDV       L    E+++  T+  A  +I  +  +  Y +DVW
Sbjct:   72 KNIIVFYGSQTGTAEEFANRLSKDAQRYGMKGMAADPEEYTMGELARMSEI-KNSLAIFCMATYGEGDPTDNAQDFYDWLQENDDEDLSGLNYTVFALGNKTYEHYNAMGKYVDKRLEELGAKRIFDLGLGDDDSNLEEDFVSWREQFWPA---VCEHFGVEASADELSIRQYELKLHNDVNMN-KVFTGE------IGRLKSFEVQKPPF--------DAKNPFLAPVTVNRRLNKAGDRHLMHLELDIT-------------------GSKLRYESGDHVAVFPTNDSALVNRLGEILGV---DLDVVISLNNLDEESNKKHPFP--------CPTTYRTALTHYLDIMNPPRTNVLYELAQYASEPKDQENMRKMASSSPEGKALYQTWVLDSCRNILAILEDMPSLKPPVDHLCELLPRLQARYYSIASSSKVHPNSIHICAV-VVEYSTKTGRVNKGVATNWLKN--KLVNGHKSTVPMFIRKSQ--FRLPFKATNPVIMIGPGTGIAPFMGFIQERGWLKEQGKEVGETVLYFGCRHKNEDYIYQEELEDAEKSGVLTQLNVAFSRDQDHKV--------------YVQHLLKKNKEHVWKLIHTDNAHLYVCGDARNMAKDV----QTALYEIAEELEGMTRTQATDYIKKLMTKGRYSQDVW 669

[Close]

BLAST of methionine synthase reductase vs. Ensembl Medaka
Match: nos1 (nitric oxide synthase 1 [Source:NCBI gene;Acc:100049502])

HSP 1 Score: 113.235 bits (282), Expect = 3.017e-25
Identity = 109/401 (27.18%), Postives = 192/401 (47.88%), Query Frame = 2

Query:  863 KWKWKPGDSVGILPFNAESEVDSILSRLS-VPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAE-QRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKR----PLT-GVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQY-FEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHH-SKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            K  +KPGD +GI P N E  V +++ +L   P    N +V++E LE        +            ++     +  D+  P + V   ++ ++  + + E ++R LE+ S+ G   Y +     +  ++++L  FPS Q+P   LL  LP L+ R YS+            + +A + ++R R    P+  GVC+SW+ ++ K        +P ++R +   F + ++   P IL+GPGTG+APF  F Q+    L++      P+ L FGCR  E D I+K++     N G+   L   +SR+     G  +         KYVQ  L  H S+++   L  +   ++VCGD + M+ DVL+T   ++    +   +  DA  +I+ +R +  Y ED++
Sbjct: 1026 KLSYKPGDHLGIFPGNHEDLVTALIDKLEDAPPV--NQIVKVEFLEERNTALGVISNWTHETRIPPCTIYQAFQYFLDITTPPTPV---LLQQFAALATNEKEKRKLEILSK-GLQEYEEWKWYNNPTLVEVLEEFPSIQMPSTLLLTQLPLLQARYYSISSSPDTYPGEIHLTVA-VVSYRTRDGGGPIHHGVCSSWLNRIEKGE-----MVPCFVR-SAPSFQLPKDDQAPCILVGPGTGIAPFRSFWQHRLYNLEHNGIKSCPMILVFGCRQSEMDHIYKEETLQAKNKGVFKELYTAYSRE----PGKPK---------KYVQDVLREHLSEMVYQCLKKEGGHIYVCGDVT-MAGDVLKTVQQIV--KQQGNMSLEDAGFYISKLRDENRYHEDIF 1397

[Close]

BLAST of methionine synthase reductase vs. Ensembl Medaka
Match: nos1 (nitric oxide synthase 1 [Source:NCBI gene;Acc:100049502])

HSP 1 Score: 113.235 bits (282), Expect = 3.442e-25
Identity = 109/401 (27.18%), Postives = 192/401 (47.88%), Query Frame = 2

Query:  863 KWKWKPGDSVGILPFNAESEVDSILSRLS-VPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAE-QRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKR----PLT-GVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQY-FEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHH-SKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            K  +KPGD +GI P N E  V +++ +L   P    N +V++E LE        +            ++     +  D+  P + V   ++ ++  + + E ++R LE+ S+ G   Y +     +  ++++L  FPS Q+P   LL  LP L+ R YS+            + +A + ++R R    P+  GVC+SW+ ++ K        +P ++R +   F + ++   P IL+GPGTG+APF  F Q+    L++      P+ L FGCR  E D I+K++     N G+   L   +SR+     G  +         KYVQ  L  H S+++   L  +   ++VCGD + M+ DVL+T   ++    +   +  DA  +I+ +R +  Y ED++
Sbjct: 1033 KLSYKPGDHLGIFPGNHEDLVTALIDKLEDAPPV--NQIVKVEFLEERNTALGVISNWTHETRIPPCTIYQAFQYFLDITTPPTPV---LLQQFAALATNEKEKRKLEILSK-GLQEYEEWKWYNNPTLVEVLEEFPSIQMPSTLLLTQLPLLQARYYSISSSPDTYPGEIHLTVA-VVSYRTRDGGGPIHHGVCSSWLNRIEKGE-----MVPCFVR-SAPSFQLPKDDQAPCILVGPGTGIAPFRSFWQHRLYNLEHNGIKSCPMILVFGCRQSEMDHIYKEETLQAKNKGVFKELYTAYSRE----PGKPK---------KYVQDVLREHLSEMVYQCLKKEGGHIYVCGDVT-MAGDVLKTVQQIV--KQQGNMSLEDAGFYISKLRDENRYHEDIF 1404

[Close]

BLAST of methionine synthase reductase vs. Planmine SMEST
Match: SMESG000061482.1 (SMESG000061482.1)

HSP 1 Score: 1289.25 bits (3335), Expect = 0.000e+0
Identity = 651/658 (98.94%), Postives = 652/658 (99.09%), Query Frame = 2

Query:   68 MTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKSFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVWI 2041
            MTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEK FEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSITEKISKIEIKPIENYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGE+QDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILP NAESEVDSILSRL VPETEKNC VRLELLENLENRRAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMA FHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHS ILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVWI
Sbjct:    1 MTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKCFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSITEKISKIEIKPIENYKELLGDHLAKDMDGKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEIQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPCNAESEVDSILSRLFVPETEKNCAVRLELLENLENRRAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMANFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSNILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVWI 658

[Close]

BLAST of methionine synthase reductase vs. Planmine SMEST
Match: SMESG000022047.1 (SMESG000022047.1)

HSP 1 Score: 179.104 bits (453), Expect = 3.389e-47
Identity = 174/679 (25.63%), Postives = 292/679 (43.00%), Query Frame = 2

Query:   65 KMTCILYGSQTGQAKSIAENLYAKLKDY-IKHINIF-ELDDVEKSFEIHKL--NFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSXXXXXXXXXXXXXXNYKELLGDHLAKDMDGKNLTVPA-LPSPFLNIIYNNE----DSISNFHEPLITSMPMPSSDSELVMGEVQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGK-------MSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESV---SFAFSKVDIAPIQTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLL--HHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            K   + YGSQTG A+  A  L  +   Y +K +    E  D+E+   +  +  + AI   +T G+GD  DNA +F   ++      ++  +YTV GLG+  Y NF    K  D+ L   GA R +   + DD   +E     W + ++     +C+   I G                          D +  ++    L +PA +P    N IY  E     +      P     P  +    LV  E+        K   +SV    +++ N++ K++ GD V + P N    VD +  RL++   +   +V                   I  +N K        + ++ LL   D+  PL    L  +SEY   KS E   L  L S EG+  Y + + ++   +L +L   PS ++P   LLE+LPRL+ R YS+     +   +   + V +  I T   R + GVCT ++  M      +   +PIY+R++   F +      P I++GPG+G+APF GF++     K+  + +G   ++FGCR +  DF+++ +L+      +++ L + FSRD                +  YVQH +    + K + D ++N     ++CGD+  M+KDV  T  N+     E   T   A  ++  M+ +  +  DVW
Sbjct:   90 KNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVN-MNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMW---TSVCNHFGISG--------------------------DKIDINVRQYRLELPANVPE---NKIYKGEVTRLGAFEKQRPPFDAKNPFLAK--VLVKQELC-------KGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVA------------------IDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKS-EADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRYYSISSSPKIYPNTIHITAVLLDYI-TNTGRNMKGVCTHYL-NMKNPSPSETPVVPIYVRRSQ--FRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQ--------------SDKIYVQHLMAKEKNRKQIWD-IINSGGHFYICGDAKHMAKDVNNTLLNIF--QTEGGMTNSQAQDYLKMMQNKGRHSSDVW 686

[Close]

BLAST of methionine synthase reductase vs. Planmine SMEST
Match: SMESG000056879.1 (SMESG000056879.1)

HSP 1 Score: 73.9442 bits (180), Expect = 2.409e-13
Identity = 92/410 (22.44%), Postives = 168/410 (40.98%), Query Frame = 2

Query:  845 INVPNAKWKWKPGDSVGILPFNAESEVD-----SILSRLSVPETEKNCVVXXXXXXXXXXXXAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREG-QSFYTKCLRETSMPVLDLLNWFP--SCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQ----TFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSKILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 2038
            I   N   K+  GD + I P N++ EVD     + L R ++   ++N                K+P   +   +  +S ++I+ +  DL     K      + +      E+ RL EL   E     Y+ C  +    ++++L  FP  S  I I + + ++P ++PR YS+     V     +V ++ ++     F  R   G+C++++  +            I   +   G     +   P ILI PGTG+A F G++   E++     NIG   L FG R + RDF F  + + F  +     L   FSR+                   Y+Q  L   S+++  ++   +  +F+ G S  M + V     N+++   E   ++++A + +  M   K Y  + W
Sbjct:  233 IAFDNKNLKYDVGDVLSIYPQNSKIEVDLFFELTNLCRNTLLTIKRNL-------------NFKIPSIFV---SNSLSFENIVYYGLDLNSVPRKSFFEHFA-FISDDKVEKERLQELSDAENIDELYSYCF-QPKRTIIEVLQDFPNTSKYINISQWINLIPFIRPRDYSIASSNVVHNGEIQVLVSRVKYKTKMFNSR--IGLCSNFLCDLKP--------SDIVFSRIKKGTLKFPDSYFPLILISPGTGIAAFRGYIS--ERML--ANNIGRTLLCFGSRYKNRDFYFASEFKSFCKNNNF-KLLTAFSREEKV----------------YIQDKLKEQSELIWKIIKEPSGFLFISGRSVDMPQQVHNEIKNIII--KEGGISEKEAANILNVMEKHKRYQIETW 591

HSP 2 Score: 69.3218 bits (168), Expect = 5.674e-12
Identity = 49/153 (32.03%), Postives = 81/153 (52.94%), Query Frame = 2

Query:   77 ILYGSQTGQAKSIAENLY---AKLKDYIKHINIFELDDVEKSFE-IHKLNFAIIICSTTGDGDAPDNASKFLRLI--KIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADD--AVGLEIVVEPWLDGLYEIAKD 511
            I YGSQTG A+ +AE +Y     L      + I E++DV  +F+ + + +  I ICSTTG GD PDN   F + +  + + P  LS   + V GLGD+ Y+ +   +K + + L    A       +ADD  ++G++     W+  L+++ +D
Sbjct:    6 IFYGSQTGNAQDVAEKVYRFSQNLPPKYASVKIGEMNDV--AFDSLSQNDIFIFICSTTGQGDPPDNMKHFWQCVMKRSFNPN-LSCLDFAVFGLGDSKYNKYNFIAKKLYRRLIQLKANSMINIGLADDQHSLGIDGEFSLWIKLLWKVLED 155

The following BLAST results are available for this feature:

BLAST of methionine synthase reductase vs. Ensembl Human
BLAST of methionine synthase reductase vs. Ensembl Celegans
BLAST of methionine synthase reductase vs. Ensembl Fly
BLAST of methionine synthase reductase vs. Ensembl Zebrafish
BLAST of methionine synthase reductase vs. Ensembl Xenopus
BLAST of methionine synthase reductase vs. Ensembl Mouse
BLAST of methionine synthase reductase vs. UniProt/SwissProt
BLAST of methionine synthase reductase vs. TrEMBL
BLAST of methionine synthase reductase vs. Ensembl Cavefish
BLAST of methionine synthase reductase vs. Ensembl Sea Lamprey
BLAST of methionine synthase reductase vs. Ensembl Yeast
BLAST of methionine synthase reductase vs. Ensembl Nematostella
BLAST of methionine synthase reductase vs. Ensembl Medaka
BLAST of methionine synthase reductase vs. Planmine SMEST

BLAST of methionine synthase reductase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MTRR	1.107e-103	33.15	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
MTRR	1.223e-103	33.29	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
POR	5.841e-48	25.60	cytochrome p450 oxidoreductase [Source:HGNC Symbol...	[more]
POR	4.385e-42	25.24	cytochrome p450 oxidoreductase [Source:HGNC Symbol...	[more]
NDOR1	1.049e-38	24.18	NADPH dependent diflavin oxidoreductase 1 [Source:...	[more]

BLAST of methionine synthase reductase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mtrr-1	1.736e-79	29.44	Methionine synthase reductase [Source:UniProtKB/S...	[more]
mtrr-1	1.736e-79	29.44	Methionine synthase reductase [Source:UniProtKB/S...	[more]
emb-8	3.343e-35	26.74	NADPH--cytochrome P450 reductase [Source:UniProtK...	[more]
emb-8	3.343e-35	26.74	NADPH--cytochrome P450 reductase [Source:UniProtK...	[more]
fre-1	3.709e-31	25.12	NADPH-dependent diflavin oxidoreductase 1 [Source...	[more]

BLAST of methionine synthase reductase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Cpr	2.000e-48	24.55	gene:FBgn0015623 transcript:FBtr0331224	[more]
Cpr	2.000e-48	24.55	gene:FBgn0015623 transcript:FBtr0331223	[more]
Cpr	2.000e-48	24.55	gene:FBgn0015623 transcript:FBtr0079250	[more]
CG13667	1.504e-38	23.46	gene:FBgn0035890 transcript:FBtr0076611	[more]
CG13667	1.504e-38	23.46	gene:FBgn0035890 transcript:FBtr0076610	[more]

BLAST of methionine synthase reductase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mtrr	1.153e-117	34.30	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
mtrr	1.429e-117	34.06	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
mtrr	1.989e-113	33.85	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
mtrr	2.020e-58	32.67	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
porb	1.295e-54	25.90	P450 (cytochrome) oxidoreductase b [Source:ZFIN;Ac...	[more]

BLAST of methionine synthase reductase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MTRR	1.368e-116	34.14	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
MTRR	3.292e-116	34.14	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
MTRR	7.758e-110	33.76	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
MTRR	1.057e-105	33.19	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
MTRR	8.050e-82	35.56	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]

BLAST of methionine synthase reductase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Mtrr	4.527e-108	32.37	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
Mtrr	4.527e-108	32.37	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
Por	9.154e-51	25.38	P450 (cytochrome) oxidoreductase [Source:MGI Symbo...	[more]
Por	1.359e-41	25.26	P450 (cytochrome) oxidoreductase [Source:MGI Symbo...	[more]
Ndor1	2.484e-39	25.49	NADPH dependent diflavin oxidoreductase 1 [Source:...	[more]

BLAST of methionine synthase reductase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8C1A3\|MTRR_MOUSE	8.224e-109	32.09	Methionine synthase reductase OS=Mus musculus OX=1...	[more]
sp\|Q4JIJ2\|MTRR_BOVIN	3.166e-104	33.05	Methionine synthase reductase OS=Bos taurus OX=991...	[more]
sp\|Q9UBK8\|MTRR_HUMAN	5.318e-103	33.15	Methionine synthase reductase OS=Homo sapiens OX=9...	[more]
sp\|Q17574\|MTRR_CAEEL	2.209e-78	29.44	Methionine synthase reductase OS=Caenorhabditis el...	[more]
sp\|Q498R1\|MTRR_RAT	3.622e-71	33.13	Methionine synthase reductase OS=Rattus norvegicus...	[more]

BLAST of methionine synthase reductase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C3XSJ5	9.910e-129	34.18	Uncharacterized protein OS=Branchiostoma floridae ...	[more]
A0A2D0PRR0	1.661e-114	33.57	methionine synthase reductase OS=Ictalurus punctat...	[more]
F1RE28	2.580e-114	34.30	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
A0A2R8QQ95	3.197e-114	34.06	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
W5U6V5	3.490e-114	33.57	Methionine synthase reductase OS=Ictalurus punctat...	[more]

BLAST of methionine synthase reductase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mtrr	2.310e-117	34.34	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
mtrr	4.248e-117	34.34	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
pora	1.491e-51	25.83	NADPH--cytochrome P450 reductase [Source:NCBI gene...	[more]
porb	3.033e-48	25.41	NADPH--cytochrome P450 reductase-like [Source:NCBI...	[more]
NOS2	1.082e-35	25.33	nitric oxide synthase, inducible-like [Source:NCBI...	[more]

BLAST of methionine synthase reductase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000004550.1	1.154e-104	32.53	pep scaffold:Pmarinus_7.0:GL501143:124546:139236:-...	[more]
porb	2.722e-41	29.85	P450 (cytochrome) oxidoreductase b [Source:ZFIN;Ac...	[more]

BLAST of methionine synthase reductase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
TAH18	1.980e-34	24.93	Conserved NAPDH-dependent diflavin reductase; comp...	[more]
NCP1	1.161e-32	24.27	NADP-cytochrome P450 reductase; involved in ergost...	[more]
MET10	6.266e-15	21.89	Subunit alpha of assimilatory sulfite reductase; c...	[more]

BLAST of methionine synthase reductase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO40246	1.169e-60	31.79	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30877	2.628e-47	24.40	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39434	4.243e-35	28.31	NADPH--cytochrome P450 reductase [Source:UniProtK...	[more]
EDO39440	2.665e-29	22.71	Nitric oxide synthase [Source:UniProtKB/TrEMBL;Ac...	[more]
EDO28992	4.141e-12	29.05	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of methionine synthase reductase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mtrr	1.629e-60	32.44	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
mtrr	2.299e-60	32.44	5-methyltetrahydrofolate-homocysteine methyltransf...	[more]
POR	1.869e-52	26.72	NADPH--cytochrome P450 reductase [Source:NCBI gene...	[more]
nos1	3.017e-25	27.18	nitric oxide synthase 1 [Source:NCBI gene;Acc:1000...	[more]
nos1	3.442e-25	27.18	nitric oxide synthase 1 [Source:NCBI gene;Acc:1000...	[more]

BLAST of methionine synthase reductase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000061482.1	0.000e+0	98.94	SMESG000061482.1	[more]
SMESG000022047.1	3.389e-47	25.63	SMESG000022047.1	[more]
SMESG000056879.1	2.409e-13	22.44	SMESG000056879.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30009557 ID=SMED30009557|Name=methionine synthase reductase|organism=Schmidtea mediterranea sexual|type=transcript|length=2263bp
AAAATCTTTAGGATAACATTTGAAATGTTTTGTTTATATAATGCACTTAT
TATGTGATTTTTTAAAAATGACATGTATATTGTATGGCTCTCAAACTGGT
CAAGCTAAGTCTATTGCTGAAAATTTATATGCAAAATTAAAGGATTATAT
AAAGCACATAAATATATTTGAACTAGATGATGTAGAAAAGTCTTTTGAAA
TTCATAAATTAAATTTTGCAATCATTATTTGCTCCACAACAGGAGATGGC
GACGCACCTGATAATGCATCAAAATTTTTAAGATTAATTAAAATTTACCA
GCCTAAATACTTAAGCAATTTTAAGTATACTGTCTTAGGTTTGGGTGATA
CAAATTATTCCAATTTTTGTAATTGTAGTAAGACTATTGATCAAATTTTA
GAATCCAAAGGTGCAAGAAGATTTTATCGTTCTGATATGGCAGACGATGC
GGTCGGACTAGAAATAGTCGTTGAACCTTGGCTAGATGGATTATACGAAA
TTGCGAAGGACATGTGTAGCGAAATTCCAATTGATGGTTTCCAAAATTTG
TCAATTACTGAAAAAATTTCTAAAATTGAAATAAAACCGATTGAAAACTA
TAAAGAATTATTAGGTGATCATTTAGCAAAAGATATGGATGGGAAAAATT
TAACTGTCCCAGCGTTACCATCACCATTTCTTAATATTATTTACAATAAT
GAAGATAGTATTAGTAATTTTCACGAACCGTTAATTACTAGTATGCCTAT
GCCATCAAGCGATTCTGAATTAGTAATGGGAGAAGTTCAAGATATTACCA
AAATAACAAATAAATATGCTATAAAATCCGTTCACAGGGCGACAATTAAC
GTTCCGAATGCCAAATGGAAATGGAAACCCGGTGACTCTGTCGGCATTTT
ACCATTCAATGCCGAAAGTGAAGTCGACTCAATTTTGTCGAGATTGTCCG
TTCCTGAAACGGAAAAGAATTGCGTTGTAAGATTGGAATTGCTAGAAAAT
TTAGAAAATCGACGCGCTAAAGTACCTGAACATTTAATTGTGCGAGAAAA
TGGGAAAATGTCTCTGAAATCAATTCTCTTGTGGCTTTGTGATTTGAGAC
AGCCACTAAGCAAAGTCGGATTGCGGATAATGAGCGAGTATTGTCCAATG
AAAAGTGCTGAACAACGAAGACTTCTTGAATTATGCTCTCGGGAGGGTCA
GAGCTTTTATACTAAGTGTCTTAGAGAAACAAGCATGCCAGTTCTGGATC
TATTGAACTGGTTTCCTTCTTGCCAAATTCCGATTGTACGACTCCTCGAA
GTATTACCTCGACTTAAACCTCGAGCATATTCGTTATGTGATCTCGAGTC
CGTTTCATTTGCATTTAGTAAAGTAGATATAGCGCCAATTCAGACATTCA
GGAAGCGTCCTTTAACGGGAGTTTGCACCTCATGGATGGAAAAAATGGCA
AAGTTTCACAATGAACAGATTTGGAAGATTCCCATTTACTTACGTAAAAA
TATGAATGGATTTACAGTTTGTGAGAACCCTTCAATTCCTCATATTTTAA
TTGGTCCGGGAACCGGAGTTGCGCCATTTATTGGTTTTCTACAATATTTC
GAAAAACTAAAAAATGAAAACCAAAATATTGGTCCGATTTGGTTGTTTTT
CGGTTGCCGAAATGAAGAGCGGGATTTTATATTCAAAAAGCAATTAGAGC
ATTTTGCAAACTCTGGCATTCTCACGCATTTGTGCGTATGTTTCTCTAGA
GATAATCCCACGAATTCAGGTGATGAGCAGAAGAACTTCTGCCAGCCTCC
GAATTGCAAATATGTTCAACACTGTTTATTGCATCATTCCAAAATTCTCA
GTGATTTGCTTGTGAATCAGAATGCTCGAGTATTTGTTTGTGGTGACAGC
TCTGGAATGTCCAAAGATGTTCTTGAAACCTGGTCAAACGTGTTGCTGGG
TAATCACGAAAAGATTCAAACCAAGAGAGATGCTGATTCATTTATCACGG
GAATGAGGGTTCAGAAATTGTACCTGGAGGATGTGTGGATTTAAATTTCC
TGAAATAAGTGAAGTGCTGTGATTTTAACATTTTTCAATAGTGCTTTATC
AATAAAACATTTGATTTTCTTTTTACAAAAACCTTTAGATATATTCTTAT
TAATGAATTCAGTGGGGATCTCGTTTATGGCTTCATTGGGCGCTGCTAGC
TTAATGAATAAGTGTATATGATAAATATATTGAGGCTAAATATATTGTAT
TATTGTGCCAAAA

protein sequence of SMED30009557-orf-1

>SMED30009557-orf-1 ID=SMED30009557-orf-1|Name=SMED30009557-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=668bp
MHLLCDFLKMTCILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEK
SFEIHKLNFAIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLG
LGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDG
LYEIAKDMCSEIPIDGFQNLSITEKISKIEIKPIENYKELLGDHLAKDMD
GKNLTVPALPSPFLNIIYNNEDSISNFHEPLITSMPMPSSDSELVMGEVQ
DITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPFNAESEVDSILS
RLSVPETEKNCVVRLELLENLENRRAKVPEHLIVRENGKMSLKSILLWLC
DLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMP
VLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPI
QTFRKRPLTGVCTSWMEKMAKFHNEQIWKIPIYLRKNMNGFTVCENPSIP
HILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKK
QLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHS
KILSDLLVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADS
FITGMRVQKLYLEDVWI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR039261	FNR_nucleotide-bd
IPR001094	Flavdoxin-like
IPR001709	Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR001433	OxRdtase_FAD/NAD-bd
IPR003097	CysJ-like_FAD-binding
IPR029039	Flavoprotein-like_sf
IPR008254	Flavodoxin/NO_synth
IPR023173	NADPH_Cyt_P450_Rdtase_alpha
IPR017938	Riboflavin_synthase-like_b-brl

Vocabulary: **molecular function**
Term	Definition
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0003958	NADPH-hemoprotein reductase activity
GO:0005515	protein binding
GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
GO:0030586	[methionine synthase] reductase activity
GO:0050444	aquacobalamin reductase (NADPH) activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding
GO:0070402	NADPH binding
GO:0071949	FAD binding

Vocabulary: **biological process**
Term	Definition
GO:0055114	oxidation-reduction process
GO:0000096	sulfur amino acid metabolic process
GO:0006306	DNA methylation
GO:0006555	methionine metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009086	methionine biosynthetic process
GO:0009235	cobalamin metabolic process
GO:0032259	methylation
GO:0033353	S-adenosylmethionine cycle
GO:0043418	homocysteine catabolic process
GO:0046655	folic acid metabolic process
GO:1904042	negative regulation of cystathionine beta-synthase activity

Vocabulary: **cellular component**
Term	Definition
GO:0005737	cytoplasm
GO:0005829	cytosol

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase	PRINTS	PR00371	FPNCR	coord: 531..540 score: 44.94 coord: 502..521 score: 50.06 coord: 278..288 score: 39.71 coord: 544..555 score: 21.74 coord: 460..469 score: 32.41
IPR001094	Flavodoxin-like	PRINTS	PR00369	FLAVODOXIN	coord: 93..103 score: 46.45 coord: 12..25 score: 41.52 coord: 61..72 score: 38.93 coord: 117..136 score: 32.34
IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	GENE3D	G3DSA:3.40.50.80		coord: 499..666 e-value: 4.7E-46 score: 158.8
IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	SUPERFAMILY	SSF52343	Ferredoxin reductase-like, C-terminal NADP-linked domain	coord: 490..666
IPR003097	Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding	PFAM	PF00667	FAD_binding_1	coord: 262..465 e-value: 5.6E-22 score: 78.4
IPR023173	NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily	GENE3D	G3DSA:1.20.990.10		coord: 242..426 e-value: 3.0E-47 score: 162.9
None	No IPR available	GENE3D	G3DSA:2.40.30.10		coord: 244..467 e-value: 3.0E-47 score: 162.9
None	No IPR available	PANTHER	PTHR19384	FLAVODOXIN-RELATED	coord: 12..666
None	No IPR available	PANTHER	PTHR19384:SF84	METHIONINE SYNTHASE REDUCTASE	coord: 12..666
IPR001433	Oxidoreductase FAD/NAD(P)-binding	PFAM	PF00175	NAD_binding_1	coord: 503..627 e-value: 7.2E-12 score: 45.9
IPR029039	Flavoprotein-like superfamily	GENE3D	G3DSA:3.40.50.360		coord: 8..164 e-value: 5.1E-40 score: 138.8
IPR029039	Flavoprotein-like superfamily	SUPERFAMILY	SSF52218	Flavoproteins	coord: 12..158
IPR008254	Flavodoxin/nitric oxide synthase	PFAM	PF00258	Flavodoxin_1	coord: 13..146 e-value: 3.5E-26 score: 92.1
IPR008254	Flavodoxin/nitric oxide synthase	PROSITE	PS50902	FLAVODOXIN_LIKE	coord: 11..152 score: 24.091
IPR017938	Riboflavin synthase-like beta-barrel	SUPERFAMILY	SSF63380	Riboflavin synthase domain-like	coord: 235..487