SMED30009436

Overview
NameSMED30009436
Smed IDSMED30009436
Length (bp)1773
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SMED30009436 (SMED30009436) t-SNE clustered cells

Violin plots show distribution of expression levels for SMED30009436 (SMED30009436) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SMED30009436 (SMED30009436) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SMED30009436 (SMED30009436) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30009436

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30009436SMESG000077535.1 SmedASXL_008669SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
pharynxSMED30009436SMESG000077535.1 dd_Smed_v4_18415_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30009436SMESG000077535.1 dd_Smed_v6_18415_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Alignments
SMED30009436 aligns in the following genomic locations:
Alignment LocationAlignment Score
v31.000773:14939..27801 -7724
Homology
BLAST of SMED30009436 vs. TrEMBL
Match: R7UWI2 (Death domain-containing protein (Fragment) OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_211144 PE=4 SV=1)

HSP 1 Score: 77.411 bits (189), Expect = 4.677e-13
Identity = 37/99 (37.37%), Postives = 61/99 (61.62%), Query Frame = 2
Query: 1397 NIPQVTNDINQIDEFFKTAAPVIGSKWKDVYKKLNFDPPRDWKQIEMDLEGIDINNKRLEPDFTKLAYLSLQKWKRLSRQATIKNLIHVLKKLNLAKYV 1693
            N   + N+ +++   FK A+  +G  W  +Y+KL F P RD ++   DLE ID++N+R +  F +LA  SL+KW+RLS  A+++ LI  L+K+   + V
Sbjct:   26 NPGYMRNNSDELSSAFKIASTDLGKDWTGLYQKLPFIPSRDRRERTRDLEVIDLSNRRTDAGFEQLAMKSLEKWRRLSSAASVEELIETLRKMKKRRTV 124          
BLAST of SMED30009436 vs. TrEMBL
Match: K1PG20 (Death domain-containing protein OS=Crassostrea gigas OX=29159 GN=CGI_10005887 PE=4 SV=1)

HSP 1 Score: 79.337 bits (194), Expect = 1.040e-11
Identity = 113/484 (23.35%), Postives = 225/484 (46.49%), Query Frame = 2
Query:  377 KSEFYDLKALGKKMQSIQKIIHKIPLKMDYIFLHNLLPYCVSCIDKV-GEKEIPPITREYEEIINKNLTEIEKLAEKAKLNPISKNSDISIRKYLNIQEQVNSHVVQFGEIY-----------LQICSIVKNWIEFDTQYPEKLQETILWLRNRRLMCSNRIKALKKHQFELKTRIIDMEKSINLK---------------SNRISQTNIDAVHYTQQDKNVIAATNKIKQDILE---MNCIRNTHVIEKQQCIEHNMIRYHNEQINTYNALIKKAKKRLSHMTSILNDLTQK-QSECLDSGHKISHNLESEKESCEKFILESKNIEDEIVEIARKIAEINEQXXXXXXXXSEKLNKYAFYPTTSCSLNHLNIPQVTNDINQIDEFFKTAAPVIGSKWKDVYKKLNFDPPRDWKQIEMDLEGIDINNKRLEPDFTKLAYLSLQKWKRLSRQATIKNLIHVLKKLN---LAKYVSSQYTSKDIFG 1726
            K E+ +L  + ++ ++ +++I  +  ++      +L  YC S I++   E +I PI  EYEE+I  +  EI++     K++ ++ N    I KY  ++    S  +  G I+           ++I   +K WI  D+ YPE+L + + +  + +      IK L++ + ++  + +D +  +N                  N +   N+      +Q +N     +++K+ + +   M       +  K +  E ++ R+H  +      ++++   RL      ++D T + + E + + H        ++E   + IL    IE E+  I  +++ I+E+  I+  +   KL+     P T   +N     +VT  + Q+D+  +  A  IG  WK +Y +L F PPRD  + + D+E ID  + R +    + A  SL+KW+  +RQ  I  LI  L+KLN   LA+ + S++T ++++G
Sbjct:   94 KKEYKELVFICERARTFERMIPNLRERLVECARDHLYKYCRSFIEETYDEVQIRPII-EYEELITTSKKEIDQ-----KIDSLNNN----ILKYGEMKSPF-SEFISKGHIHTALMEEICVLNIEIAHAIKKWIADDSSYPERLLQEVFFNNSYKENLVENIKKLEEEK-QVVVKNLDKKHRVNYAVMRDHAYHKKEKHKLKNSLETVNLKIEKLEKQIENKNEEISELKEAVADKTPMAPRDRQELRRKLEKAEADLDRFHERK-----DVMERQHGRLDKELKQVSDRTYELKVEVVTNRH--------DQEEMRQGIL---GIEIEMKSILERLSSIDEKQEILKRVRELKLS-----PDTLRRINTRR-QEVTTKV-QLDDACRYVAFHIGKDWKKLYDRLPFVPPRDPDRRQKDVEVIDNISARQDRTPEESALRSLEKWRSFNRQGDIIQLIRGLRKLNKVELAQKLESRFTIQNVYG 542          
BLAST of SMED30009436 vs. TrEMBL
Match: V4B608 (Death domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_172686 PE=4 SV=1)

HSP 1 Score: 72.7886 bits (177), Expect = 1.175e-9
Identity = 119/502 (23.71%), Postives = 209/502 (41.63%), Query Frame = 2
Query:  296 QTANEEIRSPNHLLDVLERNSDLPHMMKSEFYDLKALGKKMQSIQKIIHKIPLKMDYIFL---HNLLPYCVSCIDKVGEKEIPPITREYE-------EIINKNLTEIEKLAEKAKLNPISKNSDISIRKYLNIQEQVNSHVVQFGEIYLQICSIVKNWIEFDTQYPEKLQETILWLRNRRLMCSNRIKALKKHQFELKTRIIDMEKSINLKSNRISQTNI-DAVHYTQQ----DKNVIAATNKIKQDILEMNCIRNTHV--IEKQQCIEHNMIRYHNEQINTYNALIKKAKKRLSHMTSILNDLTQKQSECLDSGHKIS------HNLESEKESCEKFILESKNIED----------EIVEIARKIAEINEQXXXXXXXXSEKLNKY---AFYPTTSCSL-NHLNIPQVTNDI-NQIDEFFKTAAPVIGSKWKDVYKKLNFDPPRDWKQIEMDLEGIDINNKRLEPDFTKLAYLSLQKWKRLSRQATIKNLIHVLKKLNLAK 1687
            QT  E  R  +  L+    +  + H  K E   + A+  +  S ++++ K     DY++     ++  YC+S   +   KEIP +  EYE         IN+   ++E++ ++ K +      D   + Y NI       VV    I+ +I + +K+WI  D  Y  KLQ+    L  R+L                           N K  R +Q    DAVH  +Q     KNV     K+   + E   +R   +  +EKQ  +E +       + + Y  L  +     +    +L D+ + Q E L    K+         + +E+++ +K I   +NI +          + V+   + AE NE+ I       + + +      +P T   L +    P    D+ +   E  K  A  IG KW  +Y +L F P RD   I+ D+E  DI+ ++ +     +A+ SL KWKRLS +A+  +L+  L+ +++++
Sbjct:   97 QTRAESCRDFSAFLNRCRTSLKVAH--KDELKKMDAILNRSVSFEEMLEKC---RDYLYKALNDHVDKYCLSFASEAQGKEIPCVL-EYENNIVAWRRKINEGFEKLEEIQDQLKTHKGDSFEDYK-KNYDNIL--YGMKVVL--SIFPRISAPLKDWITADEAYSRKLQDAANNLIKRKLE--------------------------NTKEARKTQLRAGDAVHQMRQKTYNSKNV---RKKLSHVVEEKKYLRKRELGLMEKQSNMEKSYKEKKGREESLYEDLYFERSYSPTQAKQLLADINKVQEEMLKLDKKLDFLKDNLGKVRTERKAAQKEIYRLQNIYERSVKNEEYLSQNVDRRERDAEKNEENIRDLKSKIDSITRIRAIKLHPDTLKRLYDDGYSPGRRFDLTDGFTEACKITAKGIGHKWPVLYARLPFRPTRDAALIKQDIEAFDISGQKRDQTTRDVAFKSLAKWKRLSSEASTNHLVETLRDIDMSR 558          
BLAST of SMED30009436 vs. Planmine SMEST
Match: SMESG000077535.1 (SMESG000077535.1)

HSP 1 Score: 1111.29 bits (2873), Expect = 0.000e+0
Identity = 555/560 (99.11%), Postives = 558/560 (99.64%), Query Frame = 2
Query:   59 MPISSSRRNILPPIKSKIESSRSFPIKNTNHADLSKIYKCILSIINDIEKQVLDFGDLLMHKPRSSSENVEKFLGFLEAQTANEEIRSPNHLLDVLERNSDLPHMMKSEFYDLKALGKKMQSIQKIIHKIPLKMDYIFLHNLLPYCVSCIDKVGEKEIPPITREYEEIINKNLTEIEKLAEKAKLNPISKNSDISIRKYLNIQEQVNSHVVQFGEIYLQICSIVKNWIEFDTQYPEKLQETILWLRNRRLMCSNRIKALKKHQFELKTRIIDMEKSINLKSNRISQTNIDAVHYTQQDKNVIAATNKIKQDILEMNCIRNTHVIEKQQCIEHNMIRYHNEQINTYNALIKKAKKRLSHMTSILNDLTQKQSECLDSGHKISHNLESEKESCEKFILESKNIEDEIVEIARKIAEINEQXXXXXXXXSEKLNKYAFYPTTSCSLNHLNIPQVTNDINQIDEFFKTAAPVIGSKWKDVYKKLNFDPPRDWKQIEMDLEGIDINNKRLEPDFTKLAYLSLQKWKRLSRQATIKNLIHVLKKLNLAKYVSSQYTSKDIFGNEQK 1738
            MPISSSRRNILPPIKSKIESSRSFPIKNTNHADLSKIYKC+LSIINDIEKQVLDFGDLLMHKPRSSSENVEK LGFLEAQTANEEIRSPNHLLDVLERNSDLPHMMKSEFYDLKALGKKMQSIQKIIHKIPLKMDYIFLHNLLPYCVSCIDKVGEKEIPPITREYEEIINKNLT+IEKLAEKAKLNPISKNSDISIRKYLNIQEQVNSHVVQFGEIYLQICSIVKNWIEFD+QYPEKLQETILWLRNRRLMCSNRIKALKKHQFELKTRIIDMEKSINLKSNRISQTNIDAVHYTQQDKNVIAATNKIKQDILEMNCIRNTHVIEKQQCIEHNMIRYHNEQINTYNALIKKAKKRLSHMTSILNDLTQKQSECLDSGHKISHNLESEKESCEKFILESKNIEDEIVEIARKIAEINEQIIIIHHIISEKLNKYAFYPTTSCSLNHLNIPQVTNDINQIDEFFKTAAPVIGSKWKDVYKKLNFDPPRDWKQIEMDLEGIDINNKRLEPDFTKLAYLSLQKWKRLSRQATIKNLIHVLK LNLAKYVSSQYTSKDIFGNEQK
Sbjct:    1 MPISSSRRNILPPIKSKIESSRSFPIKNTNHADLSKIYKCVLSIINDIEKQVLDFGDLLMHKPRSSSENVEKILGFLEAQTANEEIRSPNHLLDVLERNSDLPHMMKSEFYDLKALGKKMQSIQKIIHKIPLKMDYIFLHNLLPYCVSCIDKVGEKEIPPITREYEEIINKNLTKIEKLAEKAKLNPISKNSDISIRKYLNIQEQVNSHVVQFGEIYLQICSIVKNWIEFDSQYPEKLQETILWLRNRRLMCSNRIKALKKHQFELKTRIIDMEKSINLKSNRISQTNIDAVHYTQQDKNVIAATNKIKQDILEMNCIRNTHVIEKQQCIEHNMIRYHNEQINTYNALIKKAKKRLSHMTSILNDLTQKQSECLDSGHKISHNLESEKESCEKFILESKNIEDEIVEIARKIAEINEQIIIIHHIISEKLNKYAFYPTTSCSLNHLNIPQVTNDINQIDEFFKTAAPVIGSKWKDVYKKLNFDPPRDWKQIEMDLEGIDINNKRLEPDFTKLAYLSLQKWKRLSRQATIKNLIHVLKMLNLAKYVSSQYTSKDIFGNEQK 560          
The following BLAST results are available for this feature:
BLAST of SMED30009436 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 3
Match NameE-valueIdentityDescription
R7UWI24.677e-1337.37Death domain-containing protein (Fragment) OS=Capi... [more]
K1PG201.040e-1123.35Death domain-containing protein OS=Crassostrea gig... [more]
V4B6081.175e-923.71Death domain-containing protein OS=Lottia gigantea... [more]
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BLAST of SMED30009436 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30009436 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000077535.10.000e+099.11SMESG000077535.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30009436 ID=SMED30009436|Name=SMED30009436|organism=Schmidtea mediterranea sexual|type=transcript|length=1773bp
ATTAAATATCACTTAATCATATTGTTAATATTCTTGCTTCTTTCACCAAT
AGATTAACATGCCAATTTCTTCATCTCGAAGAAATATTCTACCCCCAATA
AAATCAAAAATAGAAAGTTCGAGATCCTTTCCAATCAAAAACACAAATCA
TGCAGATTTGTCAAAAATCTATAAATGCATCCTATCAATAATCAATGACA
TTGAAAAGCAAGTATTGGATTTTGGTGATTTATTGATGCATAAACCAAGG
TCATCTTCCGAAAATGTAGAAAAATTTTTAGGATTTTTAGAAGCTCAAAC
TGCGAATGAAGAAATTAGATCCCCGAATCATTTACTTGATGTTCTCGAAA
GAAACTCAGATCTACCTCACATGATGAAATCAGAATTCTATGACCTGAAA
GCCCTAGGGAAAAAAATGCAATCAATACAAAAAATTATCCATAAAATCCC
ACTAAAAATGGACTATATTTTCCTTCACAATTTACTGCCTTATTGTGTAA
GTTGTATTGATAAAGTTGGCGAAAAAGAAATACCTCCAATTACTAGAGAA
TACGAAGAGATAATAAATAAAAACCTAACGGAAATTGAAAAACTAGCAGA
AAAAGCCAAACTAAATCCAATTTCAAAAAACTCTGACATTTCAATCAGAA
AATATCTCAATATTCAGGAGCAAGTTAACTCTCATGTGGTTCAATTCGGG
GAGATTTATCTTCAAATCTGCTCCATTGTTAAAAACTGGATTGAATTTGA
TACTCAATATCCAGAAAAATTACAAGAGACCATTTTATGGCTAAGGAACA
GAAGGTTAATGTGTTCAAACCGGATAAAAGCACTCAAAAAACACCAATTT
GAGTTGAAAACCAGAATAATTGACATGGAAAAATCAATCAATCTAAAATC
AAATCGAATTTCTCAGACAAATATAGATGCCGTTCATTACACCCAACAGG
ATAAAAATGTAATTGCGGCCACAAACAAAATTAAACAGGATATTCTCGAA
ATGAATTGTATCAGGAACACTCATGTCATCGAAAAGCAACAGTGCATCGA
ACACAACATGATTAGATATCACAATGAACAAATAAATACATACAATGCAT
TAATAAAAAAGGCAAAAAAACGGCTGAGCCACATGACATCAATTTTGAAT
GATTTAACTCAAAAGCAGTCTGAGTGCTTGGACAGTGGCCATAAAATAAG
CCATAACCTCGAATCAGAAAAAGAAAGTTGTGAAAAATTCATTTTGGAGT
CAAAAAACATAGAAGACGAAATTGTTGAAATTGCGAGAAAAATTGCGGAA
ATAAATGAGCAAATAATTATTATTCATCACATCATTTCAGAAAAATTGAA
TAAATATGCTTTTTATCCTACCACCTCGTGTTCACTGAACCACTTGAATA
TCCCCCAAGTTACAAATGATATCAATCAAATAGATGAATTTTTCAAAACA
GCTGCTCCGGTAATTGGTTCAAAATGGAAGGATGTTTACAAAAAATTAAA
TTTTGATCCACCAAGAGATTGGAAACAGATTGAAATGGATTTGGAAGGGA
TAGATATTAATAATAAACGATTGGAACCAGATTTTACAAAACTCGCTTAT
TTGTCGTTACAAAAATGGAAGCGATTAAGTCGCCAAGCAACAATTAAAAA
TCTTATTCATGTTTTAAAGAAGTTGAATCTAGCGAAATATGTTTCTTCAC
AGTATACTTCAAAAGATATTTTTGGAAATGAACAAAAATAACTTTTGTTA
TATTAATGATTAATTTTAGTATA
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protein sequence of SMED30009436-orf-1

>SMED30009436-orf-1 ID=SMED30009436-orf-1|Name=SMED30009436-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=561bp
MPISSSRRNILPPIKSKIESSRSFPIKNTNHADLSKIYKCILSIINDIEK
QVLDFGDLLMHKPRSSSENVEKFLGFLEAQTANEEIRSPNHLLDVLERNS
DLPHMMKSEFYDLKALGKKMQSIQKIIHKIPLKMDYIFLHNLLPYCVSCI
DKVGEKEIPPITREYEEIINKNLTEIEKLAEKAKLNPISKNSDISIRKYL
NIQEQVNSHVVQFGEIYLQICSIVKNWIEFDTQYPEKLQETILWLRNRRL
MCSNRIKALKKHQFELKTRIIDMEKSINLKSNRISQTNIDAVHYTQQDKN
VIAATNKIKQDILEMNCIRNTHVIEKQQCIEHNMIRYHNEQINTYNALIK
KAKKRLSHMTSILNDLTQKQSECLDSGHKISHNLESEKESCEKFILESKN
IEDEIVEIARKIAEINEQIIIIHHIISEKLNKYAFYPTTSCSLNHLNIPQ
VTNDINQIDEFFKTAAPVIGSKWKDVYKKLNFDPPRDWKQIEMDLEGIDI
NNKRLEPDFTKLAYLSLQKWKRLSRQATIKNLIHVLKKLNLAKYVSSQYT
SKDIFGNEQK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000418head
PLANA:0000420parapharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR011029DEATH-like_dom_sf
IPR000488Death_domain
IPR019774Aromatic-AA_hydroxylase_C
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0016714oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
GO:0055114oxidation-reduction process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 398..418
NoneNo IPR availableCOILSCoilCoilcoord: 349..369
NoneNo IPR availableGENE3DG3DSA:1.10.533.10coord: 455..552
e-value: 2.8E-7
score: 32.2
NoneNo IPR availableCDDcd01670Deathcoord: 469..541
e-value: 4.69779E-4
score: 36.8761
IPR000488Death domainPROSITEPS50017DEATH_DOMAINcoord: 487..545
score: 9.501