Heparan sulfate 2-O-sulfotransferase 1

Overview
NameHeparan sulfate 2-O-sulfotransferase 1
Smed IDSMED30009388
Length (bp)1227
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Heparan sulfate 2-O-sulfotransferase 1 (SMED30009388) t-SNE clustered cells

Violin plots show distribution of expression levels for Heparan sulfate 2-O-sulfotransferase 1 (SMED30009388) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Heparan sulfate 2-O-sulfotransferase 1 (SMED30009388) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Heparan sulfate 2-O-sulfotransferase 1 (SMED30009388) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30009388

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
posterior sideSMED30009388 dd_Smed_v4_6699_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30009388 dd_Smed_v4_6699_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Human
Match: HS2ST1 (heparan sulfate 2-O-sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:5193])

HSP 1 Score: 296.975 bits (759), Expect = 1.466e-97
Identity = 136/261 (52.11%), Postives = 186/261 (71.26%), Query Frame = 3 
Query:  258 HDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
             + D+VI++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +QV   +NI++W  +KP FYHGHV+YLDFAK+G K+ P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  A++ AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK    +T+  +Q +  WKME EFY FA +Q++
Sbjct:   70 EEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELY-RTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQ 325
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Human
Match: AC093155.3 (novel protein)

HSP 1 Score: 258.455 bits (659), Expect = 2.947e-83
Identity = 115/211 (54.50%), Postives = 155/211 (73.46%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGY-KQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLY 896
            D+VI++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +QV   +NI++W  +KP FYHGHV+YLDFAK+G  K+P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  A++ AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY
Sbjct:   47 DMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELY 253
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Human
Match: HS2ST1 (heparan sulfate 2-O-sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:5193])

HSP 1 Score: 216.468 bits (550), Expect = 6.249e-68
Identity = 94/161 (58.39%), Postives = 123/161 (76.40%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGY-KQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCW 746
            D+VI++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +QV   +NI++W  +KP FYHGHV+YLDFAK+G  K+P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW
Sbjct:   73 DMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAEGGSDCAPEKLWLQIPFFCGHSSECW 229
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Human
Match: UST (uronyl 2-sulfotransferase [Source:HGNC Symbol;Acc:HGNC:17223])

HSP 1 Score: 140.969 bits (354), Expect = 3.021e-37
Identity = 93/275 (33.82%), Postives = 149/275 (54.18%), Query Frame = 3 
Query:  222 YLNKHFTKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGD--DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLY--DEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            YL+ H             +++NR+ K GS TV  LL  +  E   F+L  +   N   LT   Q+EL +NIS     +P  +  HV +L+F+++G  QPVYIN +R P+ R +S Y+F RFGD    + H+ R+    ++ ++   +EC+    P+C    L+  IP+FCGQ   C E G   ALE AK N+ E +  VGI E++   + +L+   P +F+G LS+Y   E  K+ ++  T +K    PE ++I+   +  + E EFY++ K+Q+
Sbjct:   87 YLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVV-LLLRILSEKHGFNLVTSDIHNKTRLTKNEQMELIKNISTAE--QPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVNRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEW-ALERAKLNVNENFLLVGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVKKTVPSPEAVQIL--YQRMRYEYEFYHYVKEQF 355
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Human
Match: HS2ST1 (heparan sulfate 2-O-sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:5193])

HSP 1 Score: 123.25 bits (308), Expect = 9.487e-34
Identity = 52/97 (53.61%), Postives = 75/97 (77.32%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGY-KQPVYINFVRRPLER 554
            D+VI++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +QV   +NI++W  +KP FYHGHV+YLDFAK+G  K+P+YIN +R P+ER
Sbjct:   15 DMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIER 111
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Celegans
Match: hst-2 (Heparan sulfate 2-O-sulfotransferase hst-2 [Source:UniProtKB/Swiss-Prot;Acc:O17645])

HSP 1 Score: 253.447 bits (646), Expect = 1.841e-81
Identity = 121/251 (48.21%), Postives = 167/251 (66.53%), Query Frame = 3 
Query:  273 VILFNRIPKTGSTTVANLL-YSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDE-GGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNF 1019
            ++++NRIPKTGSTT  N + Y + +EN    L +N TKN  +++  +Q     NI+ W    PAFYHGHVA++DF ++G   P+YIN +R PLERL+S+YYFLR+GD+YR  +KRSR  N    +ETFDEC + GG DC  K +W+QIP+FCG   +C E GN +AL  AKQN+LEKY  VG T  +R  IA+L+   P FF+G L  +D      +HLR TK+K     +TL +I+  + +KME+EFY+F
Sbjct:   41 IVIYNRIPKTGSTTFTNAIAYDLYKENGFSVLHVNMTKNRQVMSLPDQYTFVNNITTWTERLPAFYHGHVAFIDFQRFGIANPIYINIIREPLERLLSHYYFLRYGDNYRIGLKRSRAGN----NETFDECYSRGGKDCDMKQMWIQIPYFCGHYHFCTEVGNPEALRVAKQNVLEKYLLVGTTSRMRDMIALLEVTVPDFFKGALGHFDSLDANRAHLRYTKKKIPPNDQTLSMIRRDEVYKMEREFYDF 287
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Fly
Match: Hs2st (gene:FBgn0024230 transcript:FBtr0081288)

HSP 1 Score: 274.633 bits (701), Expect = 2.517e-89
Identity = 139/297 (46.80%), Postives = 188/297 (63.30%), Query Frame = 3 
Query:  228 NKHFTKTINYHDGD--VVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYK-QPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFI--SGRGKSQSFKYIKIRP 1103
            ++H + T +  D +  +V+L+NR+PKTGST+  N+ Y +C+ NK   L IN T N  +L+  NQ++  RN+S W+ +KPA YHGH+A+LDF+K+    +P+YIN VR+PL+RLVSYYYFLRFGD+YRP++ R +  NK     TFDECV    PDC  K +WLQIPFFCG A  CWE G+S AL+ AK+NL+ +Y  VG+TE +   + +L+   PR F G    Y    K SHLR T  K      T+K IQ TK W+ME + Y+FA  Q+  N   +        Q F Y KIRP
Sbjct:   57 DQHASSTTDDFDFEEHLVVLYNRVPKTGSTSFVNIAYDLCKPNKFHVLHINVTANMHVLSLPNQIQFVRNVSRWHEMKPALYHGHMAFLDFSKFQIAHKPIYINLVRKPLDRLVSYYYFLRFGDNYRPNLVRKKAGNKI----TFDECVVQKQPDCDPKNMWLQIPFFCGHAAECWEPGSSWALDQAKRNLVNEYFLVGVTEQMYEFVDLLERSLPRIFHGFREHYHNSNK-SHLRVTSSKLPPSESTIKSIQKTKIWQMENDLYDFALAQFEFNKKKLMQPDNKHVQKFMYEKIRP 348
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Fly
Match: pip (gene:FBgn0003089 transcript:FBtr0075008)

HSP 1 Score: 115.931 bits (289), Expect = 1.832e-28
Identity = 79/270 (29.26%), Postives = 139/270 (51.48%), Query Frame = 3 
Query:  273 VILFNRIPKTGSTTVANLLYSVCEENKVFSLFINT--TKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHET-----FDECVANGGPDCQ---------TKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYD-EGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQ 1031
            V+ FNR  K GS ++  L  ++ + N   +L      T+    +    + E A  +++  L +   Y  H+ +LDF ++   +P+YIN VR P+ER++S++++ R    Y+  ++  +  N+KI+ E+     F++CV +G P+CQ               Q  F+CG    C    +  A++ AK+++   YA VG  ED    + VL++  PRFFRG   +Y+    KI++  + K+K  + PE  ++I+  K +  E EFY F K +
Sbjct:  124 VLFFNRAAKVGSESMLELFMALEKYNDDLTLERRGLHTRTVRQMDKKQRRESAEFVAD--LEEGTMYIEHINWLDFDEFDLPKPIYINLVRDPVERVISWFFYAR--SSYKNAIEYRKRPNQKIKPESWYKKNFNDCVRSGDPECQYVPHTVKDSIANFKRQSLFYCGHHDDCLPFNSPTAVQMAKEHVERDYAVVGSWEDTNITLTVLENYIPRFFRGAKLMYEMHNSKITNRNKNKRKPFVEPEVKEMIR--KNFTNEYEFYYFCKQR 387
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Fly
Match: pip (gene:FBgn0003089 transcript:FBtr0075005)

HSP 1 Score: 113.235 bits (282), Expect = 2.182e-27
Identity = 83/269 (30.86%), Postives = 125/269 (46.47%), Query Frame = 3 
Query:  273 VILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNS----PILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRS--RMKNKKIQHETFDECVANGGPDCQTKYLWL---------QIPFFCGQ-AFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQ 1031
            V+ FNR+PKTGS  +  L+  +    KV    +          PIL  A Q +L  NI N  L     +  HV +L+F K+   +P+YIN VR P+ER++S+YY++R    + P  +R+   M N K  +  FD+CV +G   C      L         Q  FFCG   F C        L+ AK N+  +Y+ VG  E     +AVL++  PR+F     +Y  G           K  I  + L +++  + +  E EFY F + +
Sbjct:  124 VLFFNRVPKTGSMQLIELMRQL---GKVHDYDVEKDPQQGGVIPILETAEQSDLIDNIVN--LDDGTVFASHVNFLNFTKHEQPRPIYINMVRDPVERVISWYYYIRAPWVFVPGRRRNNREMPNPKWVNTEFDQCVTSGEKVCTYIENSLLEHVGDHRRQTLFFCGHNEFQCTPFNARLPLQLAKMNVEREYSVVGTWEHTNETLAVLEAYVPRYFADASKMYYSGLHADKQNVNPMKPHISQDILDMVR--RNFTREIEFYQFCRQR 385
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Fly
Match: pip (gene:FBgn0003089 transcript:FBtr0075003)

HSP 1 Score: 112.079 bits (279), Expect = 5.525e-27
Identity = 79/276 (28.62%), Postives = 132/276 (47.83%), Query Frame = 3 
Query:  273 VILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYA--NQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLR-----------FGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQ-TKYLWL--------QIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGK-ISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQ 1031
            ++ FNR+PK GS T   LL  + E N  F    +  +    +  A   Q E+A  IS   L +P+ +  HV + +F K+   +P+Y+N VR P+ER++S++Y++R           F D   PH    +        + F+ CV NG  +C  T+ + +        Q  FFCG  + C       ALE AK  + ++YA VG+ ED+   ++VL+   PRFF G   +Y    + ++ + +   K  +      I++  + +  E EFY F + +
Sbjct:  124 LVFFNRVPKVGSQTFMELLRRLSERNN-FQFHRDAVQKVETIRLAEDQQQEMAEVISE--LPEPSVFIKHVCFTNFTKFNLPRPIYLNVVRDPVERVISWFYYVRAPWYFVERKAAFPDLPLPHPAWLK--------KDFETCVLNGDQECTYTQGVTVEGIGDHRRQSLFFCGHDYECTPFNTVGALERAKFAVEQQYAVVGVLEDLNTTLSVLEKYVPRFFEGVRDIYATSAEYLTKINKNNFKPPVSEHVKDIVR--RNFTNEIEFYQFCRQR 386
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Fly
Match: pip (gene:FBgn0003089 transcript:FBtr0075004)

HSP 1 Score: 111.309 bits (277), Expect = 9.155e-27
Identity = 88/294 (29.93%), Postives = 141/294 (47.96%), Query Frame = 3 
Query:  216 IFYLNKHFTKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTK--NSPILTYAN---QVELARNISNWNLVKPAF-YHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFG-DDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWL----------QIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTK-----TWKMEQEFYNFAKDQ 1031
            ++ LN  F     +H  D+ I +NR+PKTGS T+  L+  + ++N     F N     + P   Y +   Q + A  I      +PAF Y  H+ Y++   +   QP+YIN +R P+ER++S++Y+ R   +  + +    + +N+    + F+ECV    P+C+  Y  L          Q  FFCG +  C       A+  AKQN+   ++ VG  ED    + VL+   PRFF+GT+ LY E     ++    +K +I P   KI +  K      +  E EFY F K +
Sbjct:  106 LWRLNPKFLNNTKFHFRDI-IFYNRVPKTGSETLIELMIQLGKKND----FQNERSPFSKPTGMYWDVKRQKQEATRILELQ-EEPAFVYVEHMNYMNIRPFHLPQPIYINMIRDPVERVISWFYYKRTPWNSVKMYKVTGKFQNRTHYTKNFEECVLTHDPECRYDYGLLFKDDSADHKRQSLFFCGHSPICEPFNTPAAIARAKQNVERDFSVVGSWEDTNVTLTVLEHYIPRFFKGTMELYYE----PNIGLAFKKANINPWKPKISERIKQIMRANFTQEYEFYYFCKQR 389
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Zebrafish
Match: hs2st1b (heparan sulfate 2-O-sulfotransferase 1b [Source:ZFIN;Acc:ZDB-GENE-100304-1])

HSP 1 Score: 295.434 bits (755), Expect = 3.773e-97
Identity = 145/287 (50.52%), Postives = 196/287 (68.29%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYK-QPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFISGRGK-------SQSFKYIKIRP 1103
            D++I++NR+PKT ST+  N+ Y +C +N+   L INTTKN+P+++  +Q+   RN+++W  +KP FYHGHV+YLDF K+G K +PVYIN VR P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECV++GG DC  + LWLQIPFFCG    CW  G+  ALE AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY  G K SHLR+T +KK    E++  +Q +  WKME EFY FA +Q++  +   S R K       SQ+F Y KI P
Sbjct:   73 DLIIIYNRVPKTASTSFTNIAYDLCGKNRFHVLHINTTKNNPVMSLQDQMRFVRNVTSWREMKPGFYHGHVSYLDFTKFGVKGKPVYINIVRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVSSGGSDCAPEKLWLQIPFFCGHYSECWNVGSKWALEQAKYNLVNEYLLVGVTEELEDFIMMLEAALPRFFRGATELYRTGKK-SHLRKTSEKKPPTKESISKLQQSNIWKMENEFYEFALEQFQF-VRAHSVREKDGELYLLSQNFFYEKIYP 353
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Zebrafish
Match: AL844196.1 (heparan sulfate 2-O-sulfotransferase 1b [Source:NCBI gene;Acc:100151174])

HSP 1 Score: 295.049 bits (754), Expect = 4.174e-97
Identity = 155/338 (45.86%), Postives = 214/338 (63.31%), Query Frame = 3 
Query:  189 SFLTLCVIFIFY---LNKHFTKTINYH-----------DG-----------DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYK-QPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFISGRGK-------SQSFKYIKIRP 1103
            SF ++ +IFI Y   +++   +T+  H           DG           D++I++NR+PKT ST+  N+ Y +C +N+   L INTTKN+P+++  +Q+   RN+++W  +KP FYHGHV+YLDF K+G K +PVYIN VR P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECV++GG DC  + LWLQIPFFCG    CW  G+  ALE AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY  G K SHLR+T +KK    E++  +Q +  WKME EFY FA +Q++  +   S R K       SQ+F Y KI P
Sbjct:   17 SFESISLIFIMYQLSISEQSQRTMARHEVREVEQRQMRDGLRETPLLPEIEDLIIIYNRVPKTASTSFTNIAYDLCGKNRFHVLHINTTKNNPVMSLQDQMRFVRNVTSWREMKPGFYHGHVSYLDFTKFGVKGKPVYINIVRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVSSGGSDCAPEKLWLQIPFFCGHYSECWNVGSKWALEQAKYNLVNEYLLVGVTEELEDFIMMLEAALPRFFRGATELYRTGKK-SHLRKTSEKKPPTKESISKLQQSNIWKMENEFYEFALEQFQF-VRAHSVREKDGELYLLSQNFFYEKIYP 348
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Zebrafish
Match: AL844196.1 (heparan sulfate 2-O-sulfotransferase 1b [Source:NCBI gene;Acc:100151174])

HSP 1 Score: 295.049 bits (754), Expect = 4.805e-97
Identity = 145/287 (50.52%), Postives = 196/287 (68.29%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYK-QPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFISGRGK-------SQSFKYIKIRP 1103
            D++I++NR+PKT ST+  N+ Y +C +N+   L INTTKN+P+++  +Q+   RN+++W  +KP FYHGHV+YLDF K+G K +PVYIN VR P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECV++GG DC  + LWLQIPFFCG    CW  G+  ALE AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY  G K SHLR+T +KK    E++  +Q +  WKME EFY FA +Q++  +   S R K       SQ+F Y KI P
Sbjct:   68 DLIIIYNRVPKTASTSFTNIAYDLCGKNRFHVLHINTTKNNPVMSLQDQMRFVRNVTSWREMKPGFYHGHVSYLDFTKFGVKGKPVYINIVRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVSSGGSDCAPEKLWLQIPFFCGHYSECWNVGSKWALEQAKYNLVNEYLLVGVTEELEDFIMMLEAALPRFFRGATELYRTGKK-SHLRKTSEKKPPTKESISKLQQSNIWKMENEFYEFALEQFQF-VRAHSVREKDGELYLLSQNFFYEKIYP 348
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Zebrafish
Match: hs2st1a (heparan sulfate 2-O-sulfotransferase 1a [Source:ZFIN;Acc:ZDB-GENE-070112-2312])

HSP 1 Score: 289.656 bits (740), Expect = 6.484e-95
Identity = 131/267 (49.06%), Postives = 185/267 (69.29%), Query Frame = 3 
Query:  240 TKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
             K +   + D V+++NR+PKT ST+  N+ Y +C +N    L INT+KN+P+++  +QV   +N++ W  +KPAFYHGHV++LDF K+G K+ P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECV+ GG DC  + LWLQIPFFCG    CW  G+  ALE AK NL+ +Y  VG+TE++   + +L++  PRFF+G   LY + GK SHLR+T +KK    E++  +Q +  WKME EFY FA +Q++
Sbjct:   62 VKEVQLEEDDTVVIYNRVPKTASTSFTNIAYDLCNKNHYHVLHINTSKNNPVMSLQDQVRFVKNVTLWKEMKPAFYHGHVSFLDFTKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVSAGGSDCAPEKLWLQIPFFCGHYSECWNIGSRWALEQAKYNLVNEYMLVGVTEELEDFVMMLEAALPRFFKGATELY-KTGKRSHLRKTSEKKPPTKESIARLQQSNIWKMENEFYEFALEQFQ 323
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Zebrafish
Match: hs2st1b (heparan sulfate 2-O-sulfotransferase 1b [Source:ZFIN;Acc:ZDB-GENE-100304-1])

HSP 1 Score: 198.749 bits (504), Expect = 1.593e-61
Identity = 105/204 (51.47%), Postives = 134/204 (65.69%), Query Frame = 3 
Query:  513 QPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFISGRGK-------SQSFKYIKIRP 1103
            +PVYIN VR P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECV++GG DC  + LWLQIPFFCG    CW  G+  ALE AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK    E++  +Q +  WKME EFY FA +Q++  +   S R K       SQ+F Y KI P
Sbjct:   11 KPVYINIVRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVSSGGSDCAPEKLWLQIPFFCGHYSECWNVGSKWALEQAKYNLVNEYLLVGVTEELEDFIMMLEAALPRFFRGATELY-RTGKKSHLRKTSEKKPPTKESISKLQQSNIWKMENEFYEFALEQFQF-VRAHSVREKDGELYLLSQNFFYEKIYP 208
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Xenopus
Match: hs2st1 (heparan sulfate 2-O-sulfotransferase 1 [Source:NCBI gene;Acc:100145562])

HSP 1 Score: 295.819 bits (756), Expect = 3.127e-97
Identity = 134/260 (51.54%), Postives = 185/260 (71.15%), Query Frame = 3 
Query:  261 DGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
            D D++I++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +Q+   +N+S+W  +KP FYHGH+++LDF K+G K+ P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  AL+ AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK+   ET   +Q +  WKME EFY FA +Q++
Sbjct:   71 DEDILIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQMRFVKNVSSWREMKPGFYHGHISFLDFTKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAAGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWALDQAKYNLVNEYFLVGVTEELEDFIMLLEAALPRFFRGATELY-RSGKKSHLRKTTEKKAPSKETTAKLQQSDIWKMENEFYEFALEQFQ 325
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Xenopus
Match: hs2st1 (heparan sulfate 2-O-sulfotransferase 1 [Source:NCBI gene;Acc:100145562])

HSP 1 Score: 238.424 bits (607), Expect = 6.357e-75
Identity = 119/262 (45.42%), Postives = 172/262 (65.65%), Query Frame = 3 
Query:  261 DGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGY-KQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCG-QAFYCWEEGNSKALET-AKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
            D D++I++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +Q+   +N+S+W  +KP FYHGH+++LDF K+G  K+P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK+    F+E  A       + YL    P FC     +C   G   +LE  +K NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK+   ET   +Q +  WKME EFY FA +Q++
Sbjct:   71 DEDILIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQMRFVKNVSSWREMKPGFYHGHISFLDFTKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKV----FNEPCA-----VTSNYL----PLFCACSLLHC---GEKASLENQSKYNLVNEYFLVGVTEELEDFIMLLEAALPRFFRGATELY-RSGKKSHLRKTTEKKAPSKETTAKLQQSDIWKMENEFYEFALEQFQ 315
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Xenopus
Match: UST (uronyl-2-sulfotransferase [Source:NCBI gene;Acc:100496425])

HSP 1 Score: 137.887 bits (346), Expect = 3.719e-36
Identity = 101/311 (32.48%), Postives = 162/311 (52.09%), Query Frame = 3 
Query:  180 CIFSFLTLCVIFIFY-LN----------KHFTKTINYHD--GDVV---------ILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGD--DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYD--EGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            C+ S +  CV  +FY LN          +H+     Y D  G V          +++NR+ K GS T+  LL  +  E   F+L  +   N   LT   Q+EL +NIS  +  +P  +  HV +L+F+++G +QPVYIN VR P+ R +S Y+F RFGD    + H+ R+    ++ ++   +EC+     +C    L+  IP+FCGQ   C + G   ALE AKQN+ E +  VGI E++   + +L+   P +F+  +S+Y   E  K+ +L  T +K    P  L+++   +  K E EFY + K+Q+
Sbjct:   49 CMASLIFFCVGSLFYQLNGGPPHILLQLRHYLGNSTYMDDHGPVSPKILPFPSQVVYNRVGKCGSRTIV-LLLRILSEKHGFNLVTSDIHNKTRLTRNEQMELIKNISTAD--QPYLFTRHVHFLNFSRFGAEQPVYINIVRDPVSRFLSNYFFRRFGDWRGEQNHMIRTPGMKEEERNLDINECILENYAECSNPRLFYIIPYFCGQHPKCRDPG-EWALERAKQNVNENFLLVGILEELEDVLLLLERFLPHYFKDVMSIYKNPEHRKLGNLTVTVKKTFPSPAALQVL--YQRMKYEYEFYYYVKEQF 353
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Xenopus
Match: UST (uronyl-2-sulfotransferase [Source:NCBI gene;Acc:100496425])

HSP 1 Score: 137.502 bits (345), Expect = 4.429e-36
Identity = 101/311 (32.48%), Postives = 162/311 (52.09%), Query Frame = 3 
Query:  180 CIFSFLTLCVIFIFY-LN----------KHFTKTINYHD--GDVV---------ILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGD--DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYD--EGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            C+ S +  CV  +FY LN          +H+     Y D  G V          +++NR+ K GS T+  LL  +  E   F+L  +   N   LT   Q+EL +NIS  +  +P  +  HV +L+F+++G +QPVYIN VR P+ R +S Y+F RFGD    + H+ R+    ++ ++   +EC+     +C    L+  IP+FCGQ   C + G   ALE AKQN+ E +  VGI E++   + +L+   P +F+  +S+Y   E  K+ +L  T +K    P  L+++   +  K E EFY + K+Q+
Sbjct:   41 CMASLIFFCVGSLFYQLNGGPPHILLQLRHYLGNSTYMDDHGPVSPKILPFPSQVVYNRVGKCGSRTIV-LLLRILSEKHGFNLVTSDIHNKTRLTRNEQMELIKNISTAD--QPYLFTRHVHFLNFSRFGAEQPVYINIVRDPVSRFLSNYFFRRFGDWRGEQNHMIRTPGMKEEERNLDINECILENYAECSNPRLFYIIPYFCGQHPKCRDPG-EWALERAKQNVNENFLLVGILEELEDVLLLLERFLPHYFKDVMSIYKNPEHRKLGNLTVTVKKTFPSPAALQVL--YQRMKYEYEFYYYVKEQF 345
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Mouse
Match: Hs2st1 (heparan sulfate 2-O-sulfotransferase 1 [Source:MGI Symbol;Acc:MGI:1346049])

HSP 1 Score: 298.901 bits (764), Expect = 1.720e-98
Identity = 134/261 (51.34%), Postives = 186/261 (71.26%), Query Frame = 3 
Query:  258 HDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
             + D++I++NR+PKT ST+  N+ Y +C +N+   L INTTKN+P+++  +QV   +NI+ WN +KP FYHGH++YLDFAK+G K+ P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  A++ AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK    +T+  +Q +  WKME EFY FA +Q++
Sbjct:   70 EEEDIIIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNITTWNEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKSNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATDLY-RTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQ 325
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Mouse
Match: Ust (uronyl-2-sulfotransferase [Source:MGI Symbol;Acc:MGI:2442406])

HSP 1 Score: 140.584 bits (353), Expect = 3.018e-37
Identity = 92/275 (33.45%), Postives = 149/275 (54.18%), Query Frame = 3 
Query:  222 YLNKHFTKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGD--DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLY--DEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            YL+ H             +++NR+ K GS TV  LL  +  E   F+L  +   N   LT   Q+EL +NIS     +P  +  HV +L+F+++G  QPVYIN +R P+ R +S Y+F RFGD    + H+ R+    ++ ++   +EC+    P+C    L+  IP+FCGQ   C E G   ALE AK N+ E +  VGI E++   + +L+   P +F+G LS+Y   E  K+ ++  T +K    PE ++I+   +  + E EFY++ ++Q+
Sbjct:   88 YLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVV-LLLRILSEKHGFNLVTSDIHNKTRLTKNEQMELIKNISTAE--QPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVSRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEW-ALERAKLNVNENFLLVGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVRKTVPSPEAVQIL--YQRMRYEYEFYHYVREQF 356
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. UniProt/SwissProt
Match: sp|Q76KB1|HS2ST_CHICK (Heparan sulfate 2-O-sulfotransferase 1 OS=Gallus gallus OX=9031 GN=HS2ST1 PE=1 SV=1)

HSP 1 Score: 300.056 bits (767), Expect = 3.349e-98
Identity = 138/261 (52.87%), Postives = 187/261 (71.65%), Query Frame = 3 
Query:  258 HDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
             + DVVI++NR+PKT ST+  N+ Y +C +N+   L INTTKN+P+++  +QV   +N+++W  +KP FYHGHV+YLDFAK+G K+ P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  ALE AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY  G K SHLR+T +KK    ET+  +Q ++ WKME EFY FA +Q++
Sbjct:   70 EEDDVVIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNVTSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAAGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWALEQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKK-SHLRKTTEKKLPTKETIAKLQQSEIWKMENEFYEFALEQFQ 325
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. UniProt/SwissProt
Match: sp|Q8R3H7|HS2ST_MOUSE (Heparan sulfate 2-O-sulfotransferase 1 OS=Mus musculus OX=10090 GN=Hs2st1 PE=1 SV=2)

HSP 1 Score: 298.901 bits (764), Expect = 1.203e-97
Identity = 134/261 (51.34%), Postives = 186/261 (71.26%), Query Frame = 3 
Query:  258 HDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
             + D++I++NR+PKT ST+  N+ Y +C +N+   L INTTKN+P+++  +QV   +NI+ WN +KP FYHGH++YLDFAK+G K+ P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  A++ AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK    +T+  +Q +  WKME EFY FA +Q++
Sbjct:   70 EEEDIIIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNITTWNEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKSNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATDLY-RTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQ 325
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. UniProt/SwissProt
Match: sp|O08889|HS2ST_CRILO (Heparan sulfate 2-O-sulfotransferase 1 OS=Cricetulus longicaudatus OX=10030 GN=HS2ST1 PE=1 SV=1)

HSP 1 Score: 298.516 bits (763), Expect = 1.816e-97
Identity = 135/261 (51.72%), Postives = 186/261 (71.26%), Query Frame = 3 
Query:  258 HDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGY-KQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
             + D+VI++NR+PKT ST+  N+ Y +C +N+   L INTTKN+P+++  +QV   +NI+ WN +KP FYHGH++YLDFAK+G  K+P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  A++ AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK    +T+  +Q +  WKME EFY FA +Q++
Sbjct:   70 EEEDIVIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNITTWNEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATDLY-RTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQ 325
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. UniProt/SwissProt
Match: sp|O93336|HS2ST_XENLA (Heparan sulfate 2-O-sulfotransferase 1 OS=Xenopus laevis OX=8355 GN=hs2st1 PE=2 SV=1)

HSP 1 Score: 297.36 bits (760), Expect = 4.276e-97
Identity = 136/260 (52.31%), Postives = 185/260 (71.15%), Query Frame = 3 
Query:  261 DGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
            D D++I++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +QV   +N+S+W  +KP FYHGHV++LDF K+G K+ P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  AL+ AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK+   ET   +Q +  WKME EFY FA +Q++
Sbjct:   71 DEDILIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNVSSWREMKPGFYHGHVSFLDFTKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAAGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWALDQAKYNLVNEYFLVGVTEELEDFIMLLEAALPRFFRGATELY-RSGKKSHLRKTTEKKAPSKETTAKLQQSDIWKMENEFYEFALEQFQ 325
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. UniProt/SwissProt
Match: sp|Q7LGA3|HS2ST_HUMAN (Heparan sulfate 2-O-sulfotransferase 1 OS=Homo sapiens OX=9606 GN=HS2ST1 PE=1 SV=1)

HSP 1 Score: 296.975 bits (759), Expect = 7.039e-97
Identity = 136/261 (52.11%), Postives = 186/261 (71.26%), Query Frame = 3 
Query:  258 HDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
             + D+VI++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +QV   +NI++W  +KP FYHGHV+YLDFAK+G K+ P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  A++ AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK    +T+  +Q +  WKME EFY FA +Q++
Sbjct:   70 EEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELY-RTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQ 325
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. TrEMBL
Match: A0A151WJ66 (Heparan sulfate 2-O-sulfotransferase 1 OS=Trachymyrmex zeteki OX=64791 GN=ALC60_13137 PE=4 SV=1)

HSP 1 Score: 304.679 bits (779), Expect = 1.084e-97
Identity = 147/283 (51.94%), Postives = 196/283 (69.26%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRS---NIDFISGRGKSQSFKYIKIRP 1103
            DVV+++NR+PKT ST+   L+Y +C++NK   L IN T N   LT+ANQV+ A NISNWN +KPAFYHGH+A+L+F K+G K+ P+YIN +R+PL+R +SYYYFLR+GD++RPHV R +  + K    TFDEC+ +G PDC    +WLQIPF CG    CWE GNS ALE AK+NL   Y  VG+TE++   + VL+++ PRFFRG  + +    K SHLRQT QK + LPET+ IIQ +  WKME EFYNFA + + +    +   S +  +Q F Y KIRP
Sbjct:   66 DVVVIYNRVPKTASTSFMGLVYDLCKQNKYHVLHINVTNNMHTLTFANQVQFANNISNWNGIKPAFYHGHMAFLNFGKFGTKRMPLYINLLRKPLDRFISYYYFLRYGDNFRPHVIRKKHGDTK----TFDECINSGQPDCDPNNMWLQIPFLCGHDPACWEIGNSWALEEAKRNLQRYYFLVGVTEELNEFVEVLENVLPRFFRGAYNFFLHNNK-SHLRQTTQKLNPLPETVDIIQQSVVWKMENEFYNFALEHFHAVKRRLINASPQDVNQRFMYEKIRP 343
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. TrEMBL
Match: F4W7L0 (Heparan sulfate 2-O-sulfotransferase 1 OS=Acromyrmex echinatior OX=103372 GN=G5I_01426 PE=4 SV=1)

HSP 1 Score: 303.523 bits (776), Expect = 3.207e-97
Identity = 145/283 (51.24%), Postives = 196/283 (69.26%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRS---NIDFISGRGKSQSFKYIKIRP 1103
            DV++++NR+PKT ST+   L+Y +C++NK   L IN T N   LT+ANQ++ A NISNWN +KPAFYHGH+A+L+F K+G K+ P+YIN +R+PL+R +SYYYFLR+GD++RPHV R +  + K    TFDEC+ +G PDC    +WLQIPF CG    CWE GNS ALE AK+NL   Y  VG+TE++   + VL+++ PRFFRG  + +    K SHLRQT QK + LPET+ IIQ +  WKME EFYNFA + + +    +   S +  +Q F Y KIRP
Sbjct:   66 DVIVIYNRVPKTASTSFMGLVYDLCKQNKYHVLHINVTNNMHTLTFANQIQFANNISNWNSIKPAFYHGHMAFLNFGKFGTKRMPLYINLLRKPLDRFISYYYFLRYGDNFRPHVIRKKHGDTK----TFDECINSGQPDCDPNNMWLQIPFLCGHDPACWEIGNSWALEEAKRNLQRYYFLVGVTEELNEFVEVLENVLPRFFRGAYNFFLHNNK-SHLRQTTQKLNPLPETVDIIQQSVIWKMENEFYNFALEHFHAVKRRLINASPQDVNQRFMYEKIRP 343
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. TrEMBL
Match: A0A195ESL4 (Heparan sulfate 2-O-sulfotransferase 1 OS=Trachymyrmex septentrionalis OX=34720 GN=ALC56_14486 PE=4 SV=1)

HSP 1 Score: 303.523 bits (776), Expect = 3.613e-97
Identity = 146/283 (51.59%), Postives = 196/283 (69.26%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRS---NIDFISGRGKSQSFKYIKIRP 1103
            DVV+++NR+PKT ST+   L+Y +C++NK   L IN T N   LT+ANQV+ A NISNWN +KPAFYHGH+A+L+F K+G K+ P+YIN +R+PL+R +SYYYFLR+GD++RPHV R +  + K    TFDEC+ +G PDC    +WLQIPF CG    CWE GNS ALE AK+NL   Y  VG+TE++   + VL+++ PRFF+G  + +    K SHLRQT QK + LPET+ IIQ +  WKME EFYNFA + + +    +   S +  +Q F Y KIRP
Sbjct:   66 DVVVIYNRVPKTASTSFMGLVYDLCKQNKYHVLHINVTNNMHTLTFANQVQFANNISNWNSIKPAFYHGHMAFLNFGKFGTKRMPLYINLLRKPLDRFISYYYFLRYGDNFRPHVIRKKHGDTK----TFDECINSGQPDCDPNNMWLQIPFLCGHDPACWEIGNSWALEEAKRNLQRYYFLVGVTEELNEFVEVLENVLPRFFKGAYNFFLHNNK-SHLRQTTQKLNPLPETVDIIQQSVVWKMENEFYNFALEHFHAVKRRLINASPQDINQRFMYEKIRP 343
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. TrEMBL
Match: A0A1V4JYZ5 (Heparan sulfate 2-O-sulfotransferase 1 OS=Patagioenas fasciata monilis OX=372326 GN=HS2ST1 PE=4 SV=1)

HSP 1 Score: 302.368 bits (773), Expect = 5.463e-97
Identity = 139/260 (53.46%), Postives = 187/260 (71.92%), Query Frame = 3 
Query:  261 DGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGY-KQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
            D DVVI++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +QV   +N+++W  +KP FYHGH++YLDFAK+G  K+P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  ALE AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK    ET+  +Q ++ WKME EFY FA +Q++
Sbjct:   40 DDDVVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNVTSWKEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAAGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWALEQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELY-RTGKKSHLRKTTEKKLPTKETIAKLQQSEIWKMENEFYEFALEQFQ 294
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. TrEMBL
Match: A0A094KVY3 (Heparan sulfate 2-O-sulfotransferase 1 (Fragment) OS=Antrostomus carolinensis OX=279965 GN=N321_00849 PE=4 SV=1)

HSP 1 Score: 301.597 bits (771), Expect = 6.629e-97
Identity = 139/260 (53.46%), Postives = 187/260 (71.92%), Query Frame = 3 
Query:  261 DGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGY-KQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
            D DVVI++NR+PKT ST+  N+ Y +C +NK   L INTTKN+P+++  +QV   +N+++W  +KP FYHGH++YLDFAK+G  K+P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG +  CW  G+  ALE AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY   GK SHLR+T +KK    ET+  +Q ++ WKME EFY FA +Q++
Sbjct:   30 DDDVVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNVTSWKEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAAGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWALEQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELY-RTGKKSHLRKTTEKKLPTKETIAKLQQSEIWKMENEFYEFALEQFQ 284
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Cavefish
Match: hs2st1a (heparan sulfate 2-O-sulfotransferase 1 [Source:NCBI gene;Acc:103039689])

HSP 1 Score: 291.967 bits (746), Expect = 5.408e-96
Identity = 132/260 (50.77%), Postives = 183/260 (70.38%), Query Frame = 3 
Query:  261 DGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGY-KQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
            + D+V+++NR+PKT ST+  N+ Y +C  N    L INTTKN+P+++  +QV   +N+++W  +KPAFYHGHV++LDF K+G  K+P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECVA GG DC  + LWLQIPFFCG    CW  G+  ALE AK NL+ +Y  VG+TE++   + +L++  PRFF+G   LY  G K SHLR+T +KK    E++  +Q +  WKME EFY FA +Q++
Sbjct:   70 EDDIVVIYNRVPKTASTSFTNIAYDLCSRNHYHVLHINTTKNNPVMSLQDQVRFVKNVTSWKEMKPAFYHGHVSFLDFTKFGVAKKPIYINIIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVAAGGSDCAPEKLWLQIPFFCGHYSECWNIGSHWALEQAKYNLVNEYMLVGVTEELEDFVMMLEATLPRFFKGATELYRTGKK-SHLRKTSEKKPPTKESIARLQQSAIWKMENEFYEFALEQFQ 324
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Cavefish
Match: hs2st1b (heparan sulfate 2-O-sulfotransferase 1b [Source:ZFIN;Acc:ZDB-GENE-100304-1])

HSP 1 Score: 280.026 bits (715), Expect = 7.898e-92
Identity = 140/290 (48.28%), Postives = 192/290 (66.21%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYK-QPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFISGRGK----------SQSFKYIKIRP 1103
            D+VI++NR+PKT ST+  N+ Y +C +N+   L INTTKN+P+++  +QV   +N+++W  +KP FYHGHVAYLDF ++G + +P+YIN VR P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECV++GG DC  + LWLQIPFFCG    C   G+  ALE AK NL+ +Y  VG+TE++   I +L++  PRFFRG   LY    K SHLR+T +KK    E+   +Q +  WKME EFY FA +Q++    F+   G           +Q+F Y KI P
Sbjct:   31 DLVIIYNRVPKTASTSFTNIAYDLCGKNRFHVLHINTTKNNPVMSLQDQVRFVKNVTSWKEMKPGFYHGHVAYLDFTRFGVRGKPIYINVVRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVSSGGSDCAPEKLWLQIPFFCGHYSEC-NVGSRWALEQAKYNLVNEYLLVGVTEELEDFIMMLEAALPRFFRGATELYR--TKKSHLRKTSEKKPPTKESTTKLQQSDIWKMENEFYEFALEQFQ----FVRAHGVREKDGELYVLAQNFFYEKIYP 309
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Cavefish
Match: usta (uronyl 2-sulfotransferase [Source:NCBI gene;Acc:103025326])

HSP 1 Score: 144.436 bits (363), Expect = 8.607e-39
Identity = 96/276 (34.78%), Postives = 148/276 (53.62%), Query Frame = 3 
Query:  222 YLNKHFTKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGD---DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGG--KISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            YL+ H             +++NR+ K GS TV  LL  +  E   F+L  +   N   LT   QVEL RNIS   + +P  Y  HV +L+F ++  +QPVYIN +R P+ R +S Y+F RFGD   +    ++  RMK+ + ++   + C+    P+C    L+  +P+FCGQ   C E G   ALE AKQN+LE +  VGI E++   + +L+ + P +F   L++Y      K+ +L  T +K     E L+++   +  K E EFYNF +DQ+
Sbjct:   81 YLDDHGPPAPKVLPFPSQVIYNRVGKCGSRTVV-LLLRILAERHQFNLVSSDIHNKTRLTKHEQVELMRNIST--IPQPFLYTRHVHFLNFTRFRIEQPVYINIIRDPINRFLSNYFFRRFGDWRGEQNHLIRTPRMKDDE-RYLDINVCILENYPECSNPRLFYIVPYFCGQHPQCREPG-VWALERAKQNVLENFLLVGILEELEDVLLLLERLLPHYFSDVLTIYKSPAFWKVGNLTGTVKKSMPTLEALQVLY--RRMKYEYEFYNFVRDQF 349
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Cavefish
Match: usta (uronyl 2-sulfotransferase [Source:NCBI gene;Acc:103025326])

HSP 1 Score: 144.05 bits (362), Expect = 1.129e-38
Identity = 93/258 (36.05%), Postives = 144/258 (55.81%), Query Frame = 3 
Query:  276 ILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGD---DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGG--KISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            +++NR+ K GS TV  LL  +  E   F+L  +   N   LT   QVEL RNIS   + +P  Y  HV +L+F ++  +QPVYIN +R P+ R +S Y+F RFGD   +    ++  RMK+ + ++   + C+    P+C    L+  +P+FCGQ   C E G   ALE AKQN+LE +  VGI E++   + +L+ + P +F   L++Y      K+ +L  T +K     E L+++   +  K E EFYNF +DQ+
Sbjct:   90 VIYNRVGKCGSRTVV-LLLRILAERHQFNLVSSDIHNKTRLTKHEQVELMRNIST--IPQPFLYTRHVHFLNFTRFRIEQPVYINIIRDPINRFLSNYFFRRFGDWRGEQNHLIRTPRMKDDE-RYLDINVCILENYPECSNPRLFYIVPYFCGQHPQCREPG-VWALERAKQNVLENFLLVGILEELEDVLLLLERLLPHYFSDVLTIYKSPAFWKVGNLTGTVKKSMPTLEALQVLY--RRMKYEYEFYNFVRDQF 340
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Cavefish
Match: UST (uronyl 2-sulfotransferase [Source:NCBI gene;Acc:103024245])

HSP 1 Score: 130.568 bits (327), Expect = 8.565e-34
Identity = 85/257 (33.07%), Postives = 140/257 (54.47%), Query Frame = 3 
Query:  276 ILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGD--DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGG--KISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            +++NR+ K GS T+  LL  + E N+ F+L  +   N   L+   Q+ L  NIS+  + +P  Y  HV +L+F ++   +PVYIN +R P+ R +S Y+F RFGD      HV R+       ++   + C+  G P+C    L+  IP+FCGQ   C E G   AL+ AK+N++E Y  VG+ E++   + +L+ + P FF   L++Y      K+ ++  T  K++   E L+++  ++    E EFY F K Q+
Sbjct:   94 VVYNRVGKCGSRTIVLLLRILAERNQ-FTLISSDIHNKTRLSKHEQMNLMVNISS--VPQPFLYTRHVHFLNFTRFHIDEPVYINIIRDPISRFLSNYFFRRFGDWRGEENHVVRTPGMKDDERYLDINTCILEGHPECSNPRLFYIIPYFCGQHPQCREPG-LWALQKAKENVMEHYLLVGVLEELEDVLLLLERLVPHFFSDVLNIYRSPDYRKLGNMTGTVHKQTPSLEALQVL--SQRMDYEYEFYRFVKAQF 344
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Sea Lamprey
Match: hs2st1b (heparan sulfate 2-O-sulfotransferase 1b [Source:ZFIN;Acc:ZDB-GENE-100304-1])

HSP 1 Score: 285.419 bits (729), Expect = 1.464e-94
Identity = 125/257 (48.64%), Postives = 185/257 (71.98%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYG-YKQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            D+++L+NR+PKTGST+  N+ Y +C  NK   L INT++N+P+++  +Q    +N++ W  +KP FYHGH+A++DF+K+G Y++P+Y+N VR P+ERLVSYYYFLRFGD+YRP ++R +  +KK    TFDECV   G DC  + LWLQIPFFCG +  CW  G+  ALE AK NL+ +Y  VG+TE++   I +L+++ PRFF+G   L+ +G K SHLR+T +KK+   +T+  +Q ++ WK+E EFY FA +Q+
Sbjct:   39 DLIVLYNRVPKTGSTSFTNIAYDLCARNKYHVLHINTSRNNPVMSLQDQARFVKNVTVWKEMKPGFYHGHLAFVDFSKFGAYRKPIYVNVVRDPIERLVSYYYFLRFGDNYRPSLRRRKQGDKK----TFDECVQEKGVDCAPEKLWLQIPFFCGHSAECWTVGSRWALEQAKLNLVNEYLLVGVTEELEDFILILEAVLPRFFKGATELFKKGTK-SHLRKTAEKKAPSADTVHTLQQSEVWKLEHEFYEFALEQF 290
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Sea Lamprey
Match: usta (uronyl 2-sulfotransferase a [Source:ZFIN;Acc:ZDB-GENE-041001-163])

HSP 1 Score: 100.908 bits (250), Expect = 1.917e-25
Identity = 56/181 (30.94%), Postives = 93/181 (51.38%), Query Frame = 3 
Query:  498 KYGYKQPVYINFVRRPLERLVSYYYFLRFGD--DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            +YG +QP YIN +R P+ R +S Y+F RFGD    + H+ R+     + +  + ++C+    P+C    L+  +P+FCGQ   C    +S AL+ AK N+++ Y  VGI E++   + VL+ + P +F   L +Y +         T   K  LP    +    +    E +FY F +DQ+
Sbjct:    1 RYGVEQPAYINIIRDPISRFLSSYFFRRFGDWRSEQIHLVRTPGMKDEERFLSVNDCILKNYPECTNPRLFYIVPYFCGQDPRC-RVPSSWALKRAKDNVVQYYLLVGILEELEDTLLVLERLLPHYFSDALKIYSDPDYFGLGNGTSSLKKQLPSRRALQVLYQRLGYEYDFYYFVRDQF 180
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Nematostella
Match: EDO43385 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYU9])

HSP 1 Score: 222.246 bits (565), Expect = 2.810e-70
Identity = 120/286 (41.96%), Postives = 172/286 (60.14%), Query Frame = 3 
Query:  267 DVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPV-YINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY---RSNIDFISGRG---KSQSFKYIKIRP 1103
            + VI++NR+PKT ST+   ++Y + E+N   ++ +N TKNS +++  +Q+  A NI+ W+   PAFYHGHV Y++F   G  +PV YIN +R+PL+RLVSYYYFLRFGD +RPH +RSR  NK++           GG     +Y+  Q+ FF    F C   GN  ALE AK++L+EKY  VG+TE +   I +L++  PRFF+G  + +  G K SHLR+T  K+ +  +TL      K WKME EFY FA+  +   +     ++  G    S  F Y KIRP
Sbjct:    2 NTVIIYNRVPKTASTSFMGVVYDLSEQNNYHTIHLNVTKNSHVMSVTDQLRFAHNITQWSERLPAFYHGHVQYIEFQSLGVTKPVIYINVIRKPLDRLVSYYYFLRFGDTFRPHKRRSRQGNKEVW----------GGLIELLEYIIKQLNFF----FPCRSPGNKWALEQAKRHLVEKYLLVGLTEQLEDFITILETALPRFFKGATNRFQTGNK-SHLRKTASKQPLQQQTLDFFYKNKIWKMENEFYEFARKVFNGVKKKTLIVNQDGSVTSSVEFFYEKIRP 272
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Nematostella
Match: EDO38740 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC38])

HSP 1 Score: 128.257 bits (321), Expect = 2.389e-34
Identity = 84/263 (31.94%), Postives = 133/263 (50.57%), Query Frame = 3 
Query:  276 ILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRM----KNKKIQHETFDECVANGGPDCQT-KYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYD-----EGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            I++NR+ K GS ++  L+  +   N     FIN  K    LT   Q+     +   +  +   +  H+ ++DF ++G   P+YIN +R PL RLVS YYF RFGD       R+R      ++  +H +FDECV     +C     L+  IPFFCGQ+  C    +  A   A  NL+ +Y  VGI E++   + VL+ + P FF+G L ++        G+     +TK KK+   E ++I++  K   +E EFY   K+++
Sbjct:    1 IIYNRVAKCGSRSMILLISELAVANGF--KFINHPKTQHFLTAKQQLAFVDMVEQQS--QSFIFTRHMYFIDFQRFGSVTPIYINLIRDPLSRLVSQYYFRRFGDG------RNRTWDFKGSEAGRHRSFDECVITNRTECMDPNALFYVIPFFCGQSRKC-RVSSKWAFRQALYNLVNRYLVVGILEEVDDFLTVLEKLLPNFFKGALEMWKMPETRRKGRRQDETRTKNKKAPSAEVVRIMK--KRLHLEYEFYEAVKERF 250
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Nematostella
Match: EDO42743 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0J3])

HSP 1 Score: 77.0258 bits (188), Expect = 4.453e-17
Identity = 43/118 (36.44%), Postives = 65/118 (55.08%), Query Frame = 3 
Query:  519 VYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRF 872
             YIN VR P++R++S+Y++L    + RP  +  +MK     +ET +EC+A   P C++    L   FFCG+  +C   G++KAL  AK N+   YA VG+ E     + VL    P F
Sbjct:   27 TYINQVRDPVKRVISHYFYLHRSQE-RPLNRIRKMKKSGFINETLEECLAKQHPGCESN---LMTRFFCGKHSFC-RSGSNKALSKAKHNISRYYASVGLLEHFSLYLRVLNKRLPEF 139
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Medaka
Match: hs2st1b (heparan sulfate 2-O-sulfotransferase 1 [Source:NCBI gene;Acc:101173693])

HSP 1 Score: 292.738 bits (748), Expect = 3.022e-96
Identity = 143/292 (48.97%), Postives = 192/292 (65.75%), Query Frame = 3 
Query:  261 DGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYG-YKQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFISGRGK----------SQSFKYIKIRP 1103
            + + VI++NR+PKT ST+  N+ Y +C +N+   L INTTKN+P+++  +QV   +N+S W  +KPAFYHGHVAYLDF+KYG  ++P+YIN VR P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECV++GG DC  + LWLQIPFFCG    CW  G+  ALE AK NLL ++  VG+TE++   I +L++  P FFRG   LY  G K SHLR+T +KK    E    +Q +  WKME +FY FA +Q++    F+               +QSF Y KI P
Sbjct:   72 EDEAVIIYNRVPKTASTSFTNIAYDLCGKNRFHVLHINTTKNNPVMSLQDQVRFVQNVSAWREMKPAFYHGHVAYLDFSKYGVMRKPMYINVVRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVSSGGSDCAPEKLWLQIPFFCGHHAECWNVGSKWALEQAKYNLLNEFLLVGVTEELEDFIMILEAALPHFFRGATELYRTGKK-SHLRKTSEKKPPTKEATAKLQQSHIWKMENDFYEFALEQFQ----FVRAHAVREKNGELYVLAQSFFYEKIYP 354
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Medaka
Match: hs2st1a (heparan sulfate 2-O-sulfotransferase 1 [Source:NCBI gene;Acc:101158479])

HSP 1 Score: 289.656 bits (740), Expect = 5.626e-95
Identity = 132/260 (50.77%), Postives = 184/260 (70.77%), Query Frame = 3 
Query:  261 DGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQ-PVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYR 1037
            + DVVI++NR+PKT ST+  N+ Y +C +N    L INTTKN+P+++  +QV   +N++ W  +KPAFYHGHV++LDF ++G K+ P+YIN +R P+ERLVSYYYFLRFGDDYRP ++R +  +KK    TFDECV+ GG DC  + LWLQIPFFCG    CW  G+  ALE AK NL+ +Y  VG+TE++   I +L++  PRFF+G   LY + GK SHLR+T +KK    E++  +Q +  WKME +FY FA +Q++
Sbjct:   73 EDDVVIIYNRVPKTASTSFTNIAYDLCGKNHYHVLHINTTKNNPVMSMQDQVRFVKNVTEWREMKPAFYHGHVSFLDFTRFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKK----TFDECVSAGGSDCAPEKLWLQIPFFCGHYSECWNVGSQWALEQAKYNLVNEYMLVGVTEELEDFIMMLEASLPRFFKGATELY-KTGKKSHLRKTSEKKPPTKESVTKLQQSNIWKMENDFYEFALEQFQ 327
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Medaka
Match: usta (uronyl 2-sulfotransferase [Source:NCBI gene;Acc:101160703])

HSP 1 Score: 145.976 bits (367), Expect = 2.971e-39
Identity = 98/275 (35.64%), Postives = 153/275 (55.64%), Query Frame = 3 
Query:  222 YLNKHFTKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGD--DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLY--DEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            YLN H +           +++NR+ K GS TV  LL  + E+++ F+LF +   N   LT   QV+L RNIS   +  P  Y  HV +L+F+++  +QPVYIN +R P+ R +S Y+F RFGD    + H+ R+       ++   + C+    P+C    ++  IP+FCGQ   C E G   ALE AKQN+LE Y  VGI E++   + +L+ + P +F G L++Y   E  K+ ++  T +K++   E LK++      + E EFYNF +DQ+
Sbjct:   83 YLNDHGSIPPRELPFPSQVVYNRVGKCGSRTVVILLRLLAEKHQ-FNLFSSDIHNKTRLTKHEQVDLMRNISK--IPPPFLYTRHVHFLNFSRFRIEQPVYINIIRDPINRFLSNYFFRRFGDWRGEQNHLIRTPGMKDDERYLDINVCILENYPECSNPRVFYIIPYFCGQHPQCREPG-VWALERAKQNVLENYLIVGILEELEEVLLMLERLLPHYFAGVLNIYKSPEYKKMGNMTGTVRKQTPSLEALKVL--YHRMRYEYEFYNFIRDQF 351
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Medaka
Match: usta (uronyl 2-sulfotransferase [Source:NCBI gene;Acc:101160703])

HSP 1 Score: 145.591 bits (366), Expect = 6.353e-39
Identity = 98/275 (35.64%), Postives = 153/275 (55.64%), Query Frame = 3 
Query:  222 YLNKHFTKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGD--DYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLY--DEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQY 1034
            YLN H +           +++NR+ K GS TV  LL  + E+++ F+LF +   N   LT   QV+L RNIS   +  P  Y  HV +L+F+++  +QPVYIN +R P+ R +S Y+F RFGD    + H+ R+       ++   + C+    P+C    ++  IP+FCGQ   C E G   ALE AKQN+LE Y  VGI E++   + +L+ + P +F G L++Y   E  K+ ++  T +K++   E LK++     +  E EFYNF +DQ+
Sbjct:  122 YLNDHGSIPPRELPFPSQVVYNRVGKCGSRTVVILLRLLAEKHQ-FNLFSSDIHNKTRLTKHEQVDLMRNISK--IPPPFLYTRHVHFLNFSRFRIEQPVYINIIRDPINRFLSNYFFRRFGDWRGEQNHLIRTPGMKDDERYLDINVCILENYPECSNPRVFYIIPYFCGQHPQCREPG-VWALERAKQNVLENYLIVGILEELEEVLLMLERLLPHYFAGVLNIYKSPEYKKMGNMTGTVRKQTPSLEALKVLYHRMRY--EYEFYNFIRDQF 390
[Close]
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Planmine SMEST
Match: SMESG000065597.1 (SMESG000065597.1)

HSP 1 Score: 655.981 bits (1691), Expect = 0.000e+0
Identity = 315/318 (99.06%), Postives = 315/318 (99.06%), Query Frame = 3 
Query:  156 MLKKKVCLCIFSFLTLCVIFIFYLNKHFTKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFISGRGKSQSFKYIKIRPLL 1109
            MLKKKVCLCIFSFLTLCVIFIFYLNKHFTKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVEL RNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVR PLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLS YDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFISGRGKSQSFKYIKIRPLL
Sbjct:    1 MLKKKVCLCIFSFLTLCVIFIFYLNKHFTKTINYHDGDVVILFNRIPKTGSTTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELVRNISNWNLVKPAFYHGHVAYLDFAKYGYKQPVYINFVRLPLERLVSYYYFLRFGDDYRPHVKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEGNSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSFYDEGGKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFISGRGKSQSFKYIKIRPLL 318
The following BLAST results are available for this feature:
BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HS2ST11.466e-9752.11heparan sulfate 2-O-sulfotransferase 1 [Source:HGN... [more]
AC093155.32.947e-8354.50novel protein[more]
HS2ST16.249e-6858.39heparan sulfate 2-O-sulfotransferase 1 [Source:HGN... [more]
UST3.021e-3733.82uronyl 2-sulfotransferase [Source:HGNC Symbol;Acc:... [more]
HS2ST19.487e-3453.61heparan sulfate 2-O-sulfotransferase 1 [Source:HGN... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
hst-21.841e-8148.21Heparan sulfate 2-O-sulfotransferase hst-2 [Sourc... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Hs2st2.517e-8946.80gene:FBgn0024230 transcript:FBtr0081288[more]
pip1.832e-2829.26gene:FBgn0003089 transcript:FBtr0075008[more]
pip2.182e-2730.86gene:FBgn0003089 transcript:FBtr0075005[more]
pip5.525e-2728.62gene:FBgn0003089 transcript:FBtr0075003[more]
pip9.155e-2729.93gene:FBgn0003089 transcript:FBtr0075004[more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hs2st1b3.773e-9750.52heparan sulfate 2-O-sulfotransferase 1b [Source:ZF... [more]
AL844196.14.174e-9745.86heparan sulfate 2-O-sulfotransferase 1b [Source:NC... [more]
AL844196.14.805e-9750.52heparan sulfate 2-O-sulfotransferase 1b [Source:NC... [more]
hs2st1a6.484e-9549.06heparan sulfate 2-O-sulfotransferase 1a [Source:ZF... [more]
hs2st1b1.593e-6151.47heparan sulfate 2-O-sulfotransferase 1b [Source:ZF... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
hs2st13.127e-9751.54heparan sulfate 2-O-sulfotransferase 1 [Source:NCB... [more]
hs2st16.357e-7545.42heparan sulfate 2-O-sulfotransferase 1 [Source:NCB... [more]
UST3.719e-3632.48uronyl-2-sulfotransferase [Source:NCBI gene;Acc:10... [more]
UST4.429e-3632.48uronyl-2-sulfotransferase [Source:NCBI gene;Acc:10... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Hs2st11.720e-9851.34heparan sulfate 2-O-sulfotransferase 1 [Source:MGI... [more]
Ust3.018e-3733.45uronyl-2-sulfotransferase [Source:MGI Symbol;Acc:M... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q76KB1|HS2ST_CHICK3.349e-9852.87Heparan sulfate 2-O-sulfotransferase 1 OS=Gallus g... [more]
sp|Q8R3H7|HS2ST_MOUSE1.203e-9751.34Heparan sulfate 2-O-sulfotransferase 1 OS=Mus musc... [more]
sp|O08889|HS2ST_CRILO1.816e-9751.72Heparan sulfate 2-O-sulfotransferase 1 OS=Cricetul... [more]
sp|O93336|HS2ST_XENLA4.276e-9752.31Heparan sulfate 2-O-sulfotransferase 1 OS=Xenopus ... [more]
sp|Q7LGA3|HS2ST_HUMAN7.039e-9752.11Heparan sulfate 2-O-sulfotransferase 1 OS=Homo sap... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A151WJ661.084e-9751.94Heparan sulfate 2-O-sulfotransferase 1 OS=Trachymy... [more]
F4W7L03.207e-9751.24Heparan sulfate 2-O-sulfotransferase 1 OS=Acromyrm... [more]
A0A195ESL43.613e-9751.59Heparan sulfate 2-O-sulfotransferase 1 OS=Trachymy... [more]
A0A1V4JYZ55.463e-9753.46Heparan sulfate 2-O-sulfotransferase 1 OS=Patagioe... [more]
A0A094KVY36.629e-9753.46Heparan sulfate 2-O-sulfotransferase 1 (Fragment) ... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hs2st1a5.408e-9650.77heparan sulfate 2-O-sulfotransferase 1 [Source:NCB... [more]
hs2st1b7.898e-9248.28heparan sulfate 2-O-sulfotransferase 1b [Source:ZF... [more]
usta8.607e-3934.78uronyl 2-sulfotransferase [Source:NCBI gene;Acc:10... [more]
usta1.129e-3836.05uronyl 2-sulfotransferase [Source:NCBI gene;Acc:10... [more]
UST8.565e-3433.07uronyl 2-sulfotransferase [Source:NCBI gene;Acc:10... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
hs2st1b1.464e-9448.64heparan sulfate 2-O-sulfotransferase 1b [Source:ZF... [more]
usta1.917e-2530.94uronyl 2-sulfotransferase a [Source:ZFIN;Acc:ZDB-G... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO433852.810e-7041.96Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO387402.389e-3431.94Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO427434.453e-1736.44Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
hs2st1b3.022e-9648.97heparan sulfate 2-O-sulfotransferase 1 [Source:NCB... [more]
hs2st1a5.626e-9550.77heparan sulfate 2-O-sulfotransferase 1 [Source:NCB... [more]
usta2.971e-3935.64uronyl 2-sulfotransferase [Source:NCBI gene;Acc:10... [more]
usta6.353e-3935.64uronyl 2-sulfotransferase [Source:NCBI gene;Acc:10... [more]
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BLAST of Heparan sulfate 2-O-sulfotransferase 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000065597.10.000e+099.06SMESG000065597.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30009388 ID=SMED30009388|Name=Heparan sulfate 2-O-sulfotransferase 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1227bp
TCTTCCGATCTTATTTTTCTTTGCAATTTTGTAGCTTTTTGATTTAGTAA
TTATAACAGCTAATGTACATCACACAATATTCTTAATTATTTATATTGCT
CAAGGGATTTTTTTGGTTTATTGCTTCAGAACTCTAAAGGTTATTGATTA
TTAATATGTTGAAGAAAAAAGTTTGCCTTTGCATTTTTAGTTTTCTGACC
CTTTGTGTAATATTCATTTTTTATTTAAATAAACATTTTACCAAAACAAT
CAATTATCATGATGGAGATGTAGTTATTTTATTTAACAGAATTCCTAAGA
CTGGAAGCACTACAGTTGCAAATTTATTATACAGTGTATGTGAAGAAAAT
AAAGTTTTCAGTTTATTTATTAATACAACTAAAAATTCACCTATTTTAAC
TTATGCCAATCAAGTTGAATTGGCGAGAAATATTTCTAATTGGAATCTAG
TTAAACCTGCATTCTATCACGGACATGTAGCGTATTTAGATTTTGCCAAA
TATGGTTACAAACAGCCAGTTTACATTAATTTCGTTCGACGGCCATTAGA
AAGATTAGTTTCTTATTATTATTTCCTACGATTCGGAGATGATTATCGTC
CACACGTTAAAAGAAGCCGTATGAAAAATAAAAAAATCCAACACGAAACA
TTTGATGAATGTGTTGCTAACGGTGGTCCAGATTGCCAAACCAAATATTT
ATGGCTGCAAATCCCATTTTTCTGCGGGCAAGCATTTTACTGCTGGGAAG
AGGGAAATTCAAAAGCTCTTGAAACTGCAAAGCAAAATCTGCTGGAAAAA
TACGCTTTCGTTGGAATTACTGAGGATATTCGAGGGGGAATCGCAGTTCT
TCAGTCAATGTTTCCCCGGTTTTTCAGGGGAACTTTGAGTCTCTATGACG
AAGGCGGGAAAATATCTCACCTCAGACAAACCAAACAGAAGAAATCGATT
CTTCCAGAAACTCTGAAAATCATTCAATCGACGAAAACTTGGAAAATGGA
GCAAGAGTTTTATAATTTTGCCAAAGATCAATATCGTAGCAATATCGATT
TTATCAGTGGCCGCGGGAAATCTCAAAGCTTCAAATACATCAAAATTCGA
CCTTTGTTGAAATAGAAGAAATTTTTTTCATTCATTTTTCAGTTTGTTGA
TGTTTTTAAATTATTTTATTGATTTTGTGTGAATCGATTTTTTCACTTAA
ATATAATTCGAGTTCATTTTTCTAAAA
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protein sequence of SMED30009388-orf-1

>SMED30009388-orf-1 ID=SMED30009388-orf-1|Name=SMED30009388-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=320bp
MLKKKVCLCIFSFLTLCVIFIFYLNKHFTKTINYHDGDVVILFNRIPKTG
STTVANLLYSVCEENKVFSLFINTTKNSPILTYANQVELARNISNWNLVK
PAFYHGHVAYLDFAKYGYKQPVYINFVRRPLERLVSYYYFLRFGDDYRPH
VKRSRMKNKKIQHETFDECVANGGPDCQTKYLWLQIPFFCGQAFYCWEEG
NSKALETAKQNLLEKYAFVGITEDIRGGIAVLQSMFPRFFRGTLSLYDEG
GKISHLRQTKQKKSILPETLKIIQSTKTWKMEQEFYNFAKDQYRSNIDFI
SGRGKSQSFKYIKIRPLLK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR007734Heparan_SO4_2-O-STrfase
IPR005331Sulfotransferase
IPR027417P-loop_NTPase
Vocabulary: molecular function
TermDefinition
GO:0008146sulfotransferase activity
GO:0004394heparan sulfate 2-O-sulfotransferase activity
GO:0016740transferase activity
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0000139Golgi membrane
GO:0005794Golgi apparatus
GO:0016020membrane
Vocabulary: biological process
TermDefinition
GO:0015014heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:0030202heparin metabolic process
GO:0060676ureteric bud formation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:3.40.50.300coord: 35..318
e-value: 1.6E-95
score: 321.7
NoneNo IPR availablePANTHERPTHR12129:SF17HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1coord: 33..316
NoneNo IPR availableTMHMMTMhelixcoord: 7..24
IPR005331SulfotransferasePFAMPF03567Sulfotransfer_2coord: 35..293
e-value: 4.0E-30
score: 105.6
IPR007734Heparan sulphate 2-O-sulfotransferasePANTHERPTHR12129HEPARAN SULFATE 2-O-SULFOTRANSFERASEcoord: 33..316
IPR027417P-loop containing nucleoside triphosphate hydrolaseSUPERFAMILYSSF52540P-loop containing nucleoside triphosphate hydrolasescoord: 40..140