PID domain-containing protein

Overview
NamePID domain-containing protein
Smed IDSMED30009336
Length (bp)1807
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of PID domain-containing protein (SMED30009336) t-SNE clustered cells

Violin plots show distribution of expression levels for PID domain-containing protein (SMED30009336) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of PID domain-containing protein (SMED30009336) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for PID domain-containing protein (SMED30009336) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30009336

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30009336h1SMcG0016636 SmedASXL_079863SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30009336h1SMcG0016636 dd_Smed_v4_12194_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30009336h1SMcG0016636 dd_Smed_v6_12194_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
goblet cellSMED30009336h1SMcG0016636 Contig1626newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
ovarySMED30009336h1SMcG0016636 Contig1626newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
testisSMED30009336h1SMcG0016636 Contig1626newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of PID domain-containing protein vs. Ensembl Human
Match: NUMB (NUMB endocytic adaptor protein [Source:HGNC Symbol;Acc:HGNC:8060])

HSP 1 Score: 257.299 bits (656), Expect = 4.400e-77
Identity = 136/283 (48.06%), Postives = 182/283 (64.31%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHP---------------PAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+   KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         ++QD + A   + +  S   P                A  ++  N+  A  +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHA--IPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTD 299          
BLAST of PID domain-containing protein vs. Ensembl Human
Match: NUMB (NUMB endocytic adaptor protein [Source:HGNC Symbol;Acc:HGNC:8060])

HSP 1 Score: 258.07 bits (658), Expect = 6.307e-77
Identity = 136/283 (48.06%), Postives = 182/283 (64.31%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHP---------------PAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+   KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         ++QD + A   + +  S   P                A  ++  N+  A  +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHA--IPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTD 299          
BLAST of PID domain-containing protein vs. Ensembl Human
Match: NUMB (NUMB endocytic adaptor protein [Source:HGNC Symbol;Acc:HGNC:8060])

HSP 1 Score: 258.07 bits (658), Expect = 6.307e-77
Identity = 136/283 (48.06%), Postives = 182/283 (64.31%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHP---------------PAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+   KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         ++QD + A   + +  S   P                A  ++  N+  A  +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHA--IPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTD 299          
BLAST of PID domain-containing protein vs. Ensembl Human
Match: NUMB (NUMB endocytic adaptor protein [Source:HGNC Symbol;Acc:HGNC:8060])

HSP 1 Score: 250.366 bits (638), Expect = 2.476e-74
Identity = 136/294 (46.26%), Postives = 183/294 (62.24%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHP---------------PAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         ++QD + A   + +  S   P                A  ++  N+  A  +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHA--IPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTD 310          
BLAST of PID domain-containing protein vs. Ensembl Human
Match: NUMB (NUMB endocytic adaptor protein [Source:HGNC Symbol;Acc:HGNC:8060])

HSP 1 Score: 250.366 bits (638), Expect = 2.476e-74
Identity = 136/294 (46.26%), Postives = 183/294 (62.24%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHP---------------PAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         ++QD + A   + +  S   P                A  ++  N+  A  +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHA--IPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTD 310          
BLAST of PID domain-containing protein vs. Ensembl Celegans
Match: num-1 (Numb-related protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTY6])

HSP 1 Score: 247.669 bits (631), Expect = 1.756e-74
Identity = 147/309 (47.57%), Postives = 183/309 (59.22%), Query Frame = 3
Query:  156 WQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDE-ISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTI-------------------LENKALQGKSG-------------SFRQ-ASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSP-FKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPI---NEEPI 968
            WQ DE  VR G C F VKYLG +EV++SRGMQVCE ALK+L+  ++K ++A+LYVSGD +RV D+  S+GL+VDQTIEKVSFC+PDR   KGFAYICRDG +RRWMCH FLA KETGERLSHAVGCAF+ICLEKK++R+ E AQ  +                    E+   +G S              SFR+  S+ +R  DPQS II E  AS+  H   I  IS         PRP  +   F  RQ SLR  P +  SS  FKR +SLR      +      K++   T L  EPI   +E+P+
Sbjct:   36 WQPDEGAVRTGTCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQSVIINEVPASN--HMDEIRRIS--------KPRPTGNPALFL-RQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTERSPEKKSF--GTQLYNEPIYEGDEDPL 331          
BLAST of PID domain-containing protein vs. Ensembl Celegans
Match: num-1 (Numb-related protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTY6])

HSP 1 Score: 247.669 bits (631), Expect = 2.726e-74
Identity = 147/309 (47.57%), Postives = 183/309 (59.22%), Query Frame = 3
Query:  156 WQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDE-ISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTI-------------------LENKALQGKSG-------------SFRQ-ASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSP-FKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPI---NEEPI 968
            WQ DE  VR G C F VKYLG +EV++SRGMQVCE ALK+L+  ++K ++A+LYVSGD +RV D+  S+GL+VDQTIEKVSFC+PDR   KGFAYICRDG +RRWMCH FLA KETGERLSHAVGCAF+ICLEKK++R+ E AQ  +                    E+   +G S              SFR+  S+ +R  DPQS II E  AS+  H   I  IS         PRP  +   F  RQ SLR  P +  SS  FKR +SLR      +      K++   T L  EPI   +E+P+
Sbjct:   50 WQPDEGAVRTGTCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQSVIINEVPASN--HMDEIRRIS--------KPRPTGNPALFL-RQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTERSPEKKSF--GTQLYNEPIYEGDEDPL 345          
BLAST of PID domain-containing protein vs. Ensembl Celegans
Match: num-1 (Numb-related protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTY6])

HSP 1 Score: 248.054 bits (632), Expect = 5.306e-74
Identity = 147/309 (47.57%), Postives = 183/309 (59.22%), Query Frame = 3
Query:  156 WQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDE-ISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTI-------------------LENKALQGKSG-------------SFRQ-ASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSP-FKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPI---NEEPI 968
            WQ DE  VR G C F VKYLG +EV++SRGMQVCE ALK+L+  ++K ++A+LYVSGD +RV D+  S+GL+VDQTIEKVSFC+PDR   KGFAYICRDG +RRWMCH FLA KETGERLSHAVGCAF+ICLEKK++R+ E AQ  +                    E+   +G S              SFR+  S+ +R  DPQS II E  AS+  H   I  IS         PRP  +   F  RQ SLR  P +  SS  FKR +SLR      +      K++   T L  EPI   +E+P+
Sbjct:   94 WQPDEGAVRTGTCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQSVIINEVPASN--HMDEIRRIS--------KPRPTGNPALFL-RQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTERSPEKKSF--GTQLYNEPIYEGDEDPL 389          
BLAST of PID domain-containing protein vs. Ensembl Celegans
Match: num-1 (Numb-related protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTY6])

HSP 1 Score: 246.899 bits (629), Expect = 9.258e-73
Identity = 147/309 (47.57%), Postives = 183/309 (59.22%), Query Frame = 3
Query:  156 WQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDE-ISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTI-------------------LENKALQGKSG-------------SFRQ-ASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSP-FKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPI---NEEPI 968
            WQ DE  VR G C F VKYLG +EV++SRGMQVCE ALK+L+  ++K ++A+LYVSGD +RV D+  S+GL+VDQTIEKVSFC+PDR   KGFAYICRDG +RRWMCH FLA KETGERLSHAVGCAF+ICLEKK++R+ E AQ  +                    E+   +G S              SFR+  S+ +R  DPQS II E  AS+  H   I  IS         PRP  +   F  RQ SLR  P +  SS  FKR +SLR      +      K++   T L  EPI   +E+P+
Sbjct:  183 WQPDEGAVRTGTCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQSVIINEVPASN--HMDEIRRISK--------PRPTGNPALFL-RQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTERSPEKKSF--GTQLYNEPIYEGDEDPL 478          
BLAST of PID domain-containing protein vs. Ensembl Fly
Match: numb (gene:FBgn0002973 transcript:FBtr0079821)

HSP 1 Score: 284.263 bits (726), Expect = 2.068e-88
Identity = 139/268 (51.87%), Postives = 184/268 (68.66%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENK-ALQGKSGSFRQASLTERL------------QDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSK 902
            ++KP  WQ DE  VR   CSF VKYLG +EVF+SRGMQVCEEALK LR+ +++ +R +L+VSGD +RV D+ +KGLIVDQTIEKVSFC+PDRNH++GF+YICRDGTTRRWMCH FLA K++GERLSHAVGCAFA+CLE+KQ+R+ E   +   + K +   ++GSFRQ +LTERL              P SA+   P A+  P  P              + RPHA+     ERQ+S R+   +   SPFKR++SLR+ ++PS++ +
Sbjct:   22 SSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPF------------AIERPHATPNML-ERQSSFRL-STIGSQSPFKRQMSLRINDLPSNADR 275          
BLAST of PID domain-containing protein vs. Ensembl Fly
Match: numb (gene:FBgn0002973 transcript:FBtr0079822)

HSP 1 Score: 284.263 bits (726), Expect = 5.288e-88
Identity = 139/268 (51.87%), Postives = 184/268 (68.66%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENK-ALQGKSGSFRQASLTERL------------QDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSK 902
            ++KP  WQ DE  VR   CSF VKYLG +EVF+SRGMQVCEEALK LR+ +++ +R +L+VSGD +RV D+ +KGLIVDQTIEKVSFC+PDRNH++GF+YICRDGTTRRWMCH FLA K++GERLSHAVGCAFA+CLE+KQ+R+ E   +   + K +   ++GSFRQ +LTERL              P SA+   P A+  P  P              + RPHA+     ERQ+S R+   +   SPFKR++SLR+ ++PS++ +
Sbjct:   63 SSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPF------------AIERPHATPNML-ERQSSFRL-STIGSQSPFKRQMSLRINDLPSNADR 316          
BLAST of PID domain-containing protein vs. Ensembl Fly
Match: numb (gene:FBgn0002973 transcript:FBtr0339526)

HSP 1 Score: 284.263 bits (726), Expect = 5.288e-88
Identity = 139/268 (51.87%), Postives = 184/268 (68.66%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENK-ALQGKSGSFRQASLTERL------------QDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSK 902
            ++KP  WQ DE  VR   CSF VKYLG +EVF+SRGMQVCEEALK LR+ +++ +R +L+VSGD +RV D+ +KGLIVDQTIEKVSFC+PDRNH++GF+YICRDGTTRRWMCH FLA K++GERLSHAVGCAFA+CLE+KQ+R+ E   +   + K +   ++GSFRQ +LTERL              P SA+   P A+  P  P              + RPHA+     ERQ+S R+   +   SPFKR++SLR+ ++PS++ +
Sbjct:   63 SSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPF------------AIERPHATPNML-ERQSSFRL-STIGSQSPFKRQMSLRINDLPSNADR 316          
BLAST of PID domain-containing protein vs. Ensembl Fly
Match: Dab (gene:FBgn0000414 transcript:FBtr0330190)

HSP 1 Score: 62.003 bits (149), Expect = 1.462e-9
Identity = 44/165 (26.67%), Postives = 79/165 (47.88%), Query Frame = 3
Query:  147 PVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALK----ALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVK--ETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKS 623
            P  ++ D  +       F+ K +G +EV ++RG ++C+EAL+    A+R   +   R  ++V+ D +R+ DE +   +    + K+SF + D    + F YI     +     H F  +K  +   ++  A+   F +  E K K+E E+A+  I      QGKS
Sbjct:   10 PCKYRNDPGRFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDS----GHRFFGIKTDKAASQVVLAMRDLFQVVFELK-KKEIEMARQQI------QGKS 163          
BLAST of PID domain-containing protein vs. Ensembl Fly
Match: Dab (gene:FBgn0000414 transcript:FBtr0305085)

HSP 1 Score: 62.003 bits (149), Expect = 1.595e-9
Identity = 44/165 (26.67%), Postives = 79/165 (47.88%), Query Frame = 3
Query:  147 PVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALK----ALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVK--ETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKS 623
            P  ++ D  +       F+ K +G +EV ++RG ++C+EAL+    A+R   +   R  ++V+ D +R+ DE +   +    + K+SF + D    + F YI     +     H F  +K  +   ++  A+   F +  E K K+E E+A+  I      QGKS
Sbjct:   10 PCKYRNDPGRFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDS----GHRFFGIKTDKAASQVVLAMRDLFQVVFELK-KKEIEMARQQI------QGKS 163          
BLAST of PID domain-containing protein vs. Ensembl Zebrafish
Match: numb (NUMB endocytic adaptor protein [Source:ZFIN;Acc:ZDB-GENE-060422-1])

HSP 1 Score: 265.774 bits (678), Expect = 9.695e-80
Identity = 143/300 (47.67%), Postives = 192/300 (64.00%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQD------------------PQSAIIAEP-LASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYE 947
            +++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+   KK +RA+L+VS D +RV D+ +K LI+DQTIEKVSFC+PDRN +  F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQKRE E   +   + N+    + GSFR  + TE         +LQD                  P    +A P  +SSPP P A   +   +    V+PR HA V   + RQ S R FP L Q++SPFKR++SLR+ E+PS+  + SD   I+ T+ + E
Sbjct:   19 SSRPHQWQTDEEAVRGGKCSFAVKYLGHVEVEESRGMHICEDAVKKLKTAGKKAVRAVLWVSADGLRVVDDKTKDLILDQTIEKVSFCAPDRNFEHAFSYICRDGTTRRWICHCFMAIKDSGERLSHAVGCAFAACLERKQKREKECGVTATFDANRTTFTREGSFRVTTATEQAEREEVMRQLQDNKKDSDLVISSSSGGSCNPVVVTLAGPNGSSSPPLPMAPLGLQDGNPH--VIPRRHAPVEALA-RQGSFRGFPALSQKTSPFKRQMSLRMNELPSTMQRKSDFP-IKNTVPEVE 314          
BLAST of PID domain-containing protein vs. Ensembl Zebrafish
Match: numbl (NUMB like endocytic adaptor protein [Source:ZFIN;Acc:ZDB-GENE-051113-340])

HSP 1 Score: 259.225 bits (661), Expect = 1.169e-77
Identity = 137/277 (49.46%), Postives = 186/277 (67.15%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQAS---------LTERLQDPQSAIIA----EPLASSPPHPPAINAISPNHTRAS-----VVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR+G C+F V+YLG +EV +SRGM VCEEA+K L+   KKT++A+L+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN+ K F+YICRDGTTRRWMCH F+A+K++GERLSHAVGCAFA CLE+KQ+RE E   +   + ++    + GSFR +S         + +++QD +  +       P  +SPP      A SP   RA       +PR HA +     RQ S R FP+L Q++SPFKR+LSLRL ++PS+  + +D
Sbjct:   20 SRPHQWQADEEAVRKGKCNFPVRYLGLVEVDESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWMCHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVSSAAQQSDREDIMKQIQDKKKEMCGISALPPGNASPPE----GAGSPGE-RAEPGGPHAIPRRHAPIEQLV-RQGSFRGFPQLSQKNSPFKRQLSLRLNDLPSTLQRKTD 290          
BLAST of PID domain-containing protein vs. Ensembl Zebrafish
Match: numbl (NUMB like endocytic adaptor protein [Source:ZFIN;Acc:ZDB-GENE-051113-340])

HSP 1 Score: 259.225 bits (661), Expect = 1.169e-77
Identity = 137/277 (49.46%), Postives = 186/277 (67.15%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQAS---------LTERLQDPQSAIIA----EPLASSPPHPPAINAISPNHTRAS-----VVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR+G C+F V+YLG +EV +SRGM VCEEA+K L+   KKT++A+L+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN+ K F+YICRDGTTRRWMCH F+A+K++GERLSHAVGCAFA CLE+KQ+RE E   +   + ++    + GSFR +S         + +++QD +  +       P  +SPP      A SP   RA       +PR HA +     RQ S R FP+L Q++SPFKR+LSLRL ++PS+  + +D
Sbjct:   20 SRPHQWQADEEAVRKGKCNFPVRYLGLVEVDESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWMCHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVSSAAQQSDREDIMKQIQDKKKEMCGISALPPGNASPPE----GAGSPGE-RAEPGGPHAIPRRHAPIEQLV-RQGSFRGFPQLSQKNSPFKRQLSLRLNDLPSTLQRKTD 290          
BLAST of PID domain-containing protein vs. Ensembl Zebrafish
Match: numbl (NUMB like endocytic adaptor protein [Source:ZFIN;Acc:ZDB-GENE-051113-340])

HSP 1 Score: 258.84 bits (660), Expect = 1.298e-77
Identity = 137/277 (49.46%), Postives = 186/277 (67.15%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQAS---------LTERLQDPQSAIIA----EPLASSPPHPPAINAISPNHTRAS-----VVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR+G C+F V+YLG +EV +SRGM VCEEA+K L+   KKT++A+L+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN+ K F+YICRDGTTRRWMCH F+A+K++GERLSHAVGCAFA CLE+KQ+RE E   +   + ++    + GSFR +S         + +++QD +  +       P  +SPP      A SP   RA       +PR HA +     RQ S R FP+L Q++SPFKR+LSLRL ++PS+  + +D
Sbjct:   20 SRPHQWQADEEAVRKGKCNFPVRYLGLVEVDESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWMCHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVSSAAQQSDREDIMKQIQDKKKEMCGISALPPGNASPPE----GAGSPGE-RAEPGGPHAIPRRHAPIEQLV-RQGSFRGFPQLSQKNSPFKRQLSLRLNDLPSTLQRKTD 290          
BLAST of PID domain-containing protein vs. Ensembl Zebrafish
Match: numbl (NUMB like endocytic adaptor protein [Source:ZFIN;Acc:ZDB-GENE-051113-340])

HSP 1 Score: 259.225 bits (661), Expect = 1.401e-77
Identity = 137/277 (49.46%), Postives = 186/277 (67.15%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQAS---------LTERLQDPQSAIIA----EPLASSPPHPPAINAISPNHTRAS-----VVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR+G C+F V+YLG +EV +SRGM VCEEA+K L+   KKT++A+L+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN+ K F+YICRDGTTRRWMCH F+A+K++GERLSHAVGCAFA CLE+KQ+RE E   +   + ++    + GSFR +S         + +++QD +  +       P  +SPP      A SP   RA       +PR HA +     RQ S R FP+L Q++SPFKR+LSLRL ++PS+  + +D
Sbjct:   42 SRPHQWQADEEAVRKGKCNFPVRYLGLVEVDESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWMCHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVSSAAQQSDREDIMKQIQDKKKEMCGISALPPGNASPPE----GAGSPGE-RAEPGGPHAIPRRHAPIEQLV-RQGSFRGFPQLSQKNSPFKRQLSLRLNDLPSTLQRKTD 312          
BLAST of PID domain-containing protein vs. Ensembl Xenopus
Match: numb (numb homolog [Source:NCBI gene;Acc:100038147])

HSP 1 Score: 262.692 bits (670), Expect = 2.277e-79
Identity = 139/286 (48.60%), Postives = 181/286 (63.29%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTERLQD------------------------PQSAIIAEP---LASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSFQVKYLG++EV +SRGM +CEEA+K L+   KK I+A+L+VS D +RV DE +K L+VDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE+ +                         P + + + P   L SSP     +   S +      +PR HA V   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + SD
Sbjct:   20 SRPHQWQTDEESVRNGKCSFQVKYLGHVEVEESRGMHICEEAVKRLKSSGKKAIKAVLWVSADGLRVVDEKTKDLLVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEVMKQIQESRKELEVKAPVVPAAPSTTVSSTPTPVLQSSPTSEVFVVQDSKDLNYPHAIPRRHAPVEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTVQRKSD 304          
BLAST of PID domain-containing protein vs. Ensembl Xenopus
Match: numb (numb homolog [Source:NCBI gene;Acc:100038147])

HSP 1 Score: 263.077 bits (671), Expect = 2.692e-79
Identity = 139/286 (48.60%), Postives = 181/286 (63.29%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTERLQD------------------------PQSAIIAEP---LASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSFQVKYLG++EV +SRGM +CEEA+K L+   KK I+A+L+VS D +RV DE +K L+VDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE+ +                         P + + + P   L SSP     +   S +      +PR HA V   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + SD
Sbjct:   20 SRPHQWQTDEESVRNGKCSFQVKYLGHVEVEESRGMHICEEAVKRLKSSGKKAIKAVLWVSADGLRVVDEKTKDLLVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEVMKQIQESRKELEVKAPVVPAAPSTTVSSTPTPVLQSSPTSEVFVVQDSKDLNYPHAIPRRHAPVEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTVQRKSD 304          
BLAST of PID domain-containing protein vs. Ensembl Xenopus
Match: numb (numb homolog [Source:NCBI gene;Acc:100038147])

HSP 1 Score: 256.529 bits (654), Expect = 2.711e-76
Identity = 139/297 (46.80%), Postives = 182/297 (61.28%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKK-----------KTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTERLQD------------------------PQSAIIAEP---LASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSFQVKYLG++EV +SRGM +CEEA+K L+  +K           K I+A+L+VS D +RV DE +K L+VDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE+ +                         P + + + P   L SSP     +   S +      +PR HA V   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + SD
Sbjct:   20 SRPHQWQTDEESVRNGKCSFQVKYLGHVEVEESRGMHICEEAVKRLKSERKYFKGFFAKSGKKAIKAVLWVSADGLRVVDEKTKDLLVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEVMKQIQESRKELEVKAPVVPAAPSTTVSSTPTPVLQSSPTSEVFVVQDSKDLNYPHAIPRRHAPVEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTVQRKSD 315          
BLAST of PID domain-containing protein vs. Ensembl Xenopus
Match: NUMBL (numb homolog-like [Source:NCBI gene;Acc:100488844])

HSP 1 Score: 252.677 bits (644), Expect = 2.054e-75
Identity = 136/281 (48.40%), Postives = 178/281 (63.35%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPP----------------HPPAINAISPNHTRAS---VVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSS 893
            ++P  W  DE  VR G CSF V+YLG++EV +SRGM VCE+A+K L+   KK+++AIL+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN  K F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  S ++         +LQD + A  A  L SS P                 PP    +    +       +PR HA +     RQ S R FP L Q++SPFKR+LSLRL E+PS+
Sbjct:   20 SRPHQWGADEEAVRRGKCSFPVRYLGHVEVEESRGMHVCEDAVKKLKTLGKKSVKAILWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNFDKAFSYICRDGTTRRWICHCFMALKDSGERLSHAVGCAFAACLERKQKREKECGVTASFDASRTSFAREGSFRVTSASQQAEREEVMRQLQDKKKAEAAPSLTSSIPAVGAPSNPVLPAQPDQSPPQCATVPSEKSETGGQHAIPRRHAPLEQLV-RQGSFRGFPALSQKNSPFKRQLSLRLNELPST 299          
BLAST of PID domain-containing protein vs. Ensembl Xenopus
Match: NUMBL (numb homolog-like [Source:NCBI gene;Acc:100488844])

HSP 1 Score: 252.677 bits (644), Expect = 2.698e-75
Identity = 136/281 (48.40%), Postives = 178/281 (63.35%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPP----------------HPPAINAISPNHTRAS---VVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSS 893
            ++P  W  DE  VR G CSF V+YLG++EV +SRGM VCE+A+K L+   KK+++AIL+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN  K F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  S ++         +LQD + A  A  L SS P                 PP    +    +       +PR HA +     RQ S R FP L Q++SPFKR+LSLRL E+PS+
Sbjct:   33 SRPHQWGADEEAVRRGKCSFPVRYLGHVEVEESRGMHVCEDAVKKLKTLGKKSVKAILWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNFDKAFSYICRDGTTRRWICHCFMALKDSGERLSHAVGCAFAACLERKQKREKECGVTASFDASRTSFAREGSFRVTSASQQAEREEVMRQLQDKKKAEAAPSLTSSIPAVGAPSNPVLPAQPDQSPPQCATVPSEKSETGGQHAIPRRHAPLEQLV-RQGSFRGFPALSQKNSPFKRQLSLRLNELPST 312          
BLAST of PID domain-containing protein vs. Ensembl Mouse
Match: Numb (NUMB endocytic adaptor protein [Source:MGI Symbol;Acc:MGI:107423])

HSP 1 Score: 258.07 bits (658), Expect = 1.600e-77
Identity = 149/317 (47.00%), Postives = 196/317 (61.83%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHPPAINA--------------ISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFST 1016
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+   KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         +LQD + A   + +   P   P   A               S        +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D   I+ T+ + E    E ISS   +I+   SAFST
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVV-GPSVAPGNTAPSPSSPTSPTPDGTASSEMNNPHAIPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFP-IKNTVPEVE-GEAESISSLCSQIT---SAFST 329          
BLAST of PID domain-containing protein vs. Ensembl Mouse
Match: Numb (NUMB endocytic adaptor protein [Source:MGI Symbol;Acc:MGI:107423])

HSP 1 Score: 258.455 bits (659), Expect = 3.448e-77
Identity = 149/317 (47.00%), Postives = 196/317 (61.83%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHPPAINA--------------ISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFST 1016
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+   KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         +LQD + A   + +   P   P   A               S        +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D   I+ T+ + E    E ISS   +I+   SAFST
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVV-GPSVAPGNTAPSPSSPTSPTPDGTASSEMNNPHAIPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFP-IKNTVPEVE-GEAESISSLCSQIT---SAFST 329          
BLAST of PID domain-containing protein vs. Ensembl Mouse
Match: Numb (NUMB endocytic adaptor protein [Source:MGI Symbol;Acc:MGI:107423])

HSP 1 Score: 248.44 bits (633), Expect = 5.084e-77
Identity = 136/293 (46.42%), Postives = 179/293 (61.09%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHPPAINA--------------ISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         +LQD + A   + +   P   P   A               S        +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVV-GPSVAPGNTAPSPSSPTSPTPDGTASSEMNNPHAIPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTD 310          
BLAST of PID domain-containing protein vs. Ensembl Mouse
Match: Numb (NUMB endocytic adaptor protein [Source:MGI Symbol;Acc:MGI:107423])

HSP 1 Score: 250.751 bits (639), Expect = 1.426e-74
Identity = 149/328 (45.43%), Postives = 197/328 (60.06%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHPPAINA--------------ISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFST 1016
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         +LQD + A   + +   P   P   A               S        +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D   I+ T+ + E    E ISS   +I+   SAFST
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVV-GPSVAPGNTAPSPSSPTSPTPDGTASSEMNNPHAIPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFP-IKNTVPEVEG-EAESISSLCSQIT---SAFST 340          
BLAST of PID domain-containing protein vs. Ensembl Mouse
Match: Numb (NUMB endocytic adaptor protein [Source:MGI Symbol;Acc:MGI:107423])

HSP 1 Score: 251.521 bits (641), Expect = 1.978e-74
Identity = 149/328 (45.43%), Postives = 197/328 (60.06%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHPPAINA--------------ISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFST 1016
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         +LQD + A   + +   P   P   A               S        +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D   I+ T+ + E    E ISS   +I+   SAFST
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVV-GPSVAPGNTAPSPSSPTSPTPDGTASSEMNNPHAIPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFP-IKNTVPEVE-GEAESISSLCSQIT---SAFST 340          
BLAST of PID domain-containing protein vs. UniProt/SwissProt
Match: sp|P16554|NUMB_DROME (Protein numb OS=Drosophila melanogaster OX=7227 GN=numb PE=1 SV=2)

HSP 1 Score: 284.263 bits (726), Expect = 5.300e-87
Identity = 139/268 (51.87%), Postives = 184/268 (68.66%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENK-ALQGKSGSFRQASLTERL------------QDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSK 902
            ++KP  WQ DE  VR   CSF VKYLG +EVF+SRGMQVCEEALK LR+ +++ +R +L+VSGD +RV D+ +KGLIVDQTIEKVSFC+PDRNH++GF+YICRDGTTRRWMCH FLA K++GERLSHAVGCAFA+CLE+KQ+R+ E   +   + K +   ++GSFRQ +LTERL              P SA+   P A+  P  P              + RPHA+     ERQ+S R+   +   SPFKR++SLR+ ++PS++ +
Sbjct:   63 SSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPF------------AIERPHATPNML-ERQSSFRL-STIGSQSPFKRQMSLRINDLPSNADR 316          
BLAST of PID domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9QZS3|NUMB_MOUSE (Protein numb homolog OS=Mus musculus OX=10090 GN=Numb PE=1 SV=1)

HSP 1 Score: 251.521 bits (641), Expect = 1.384e-73
Identity = 149/328 (45.43%), Postives = 197/328 (60.06%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHPPAINA--------------ISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFST 1016
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         +LQD + A   + +   P   P   A               S        +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D   I+ T+ + E    E ISS   +I+   SAFST
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVV-GPSVAPGNTAPSPSSPTSPTPDGTASSEMNNPHAIPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFP-IKNTVPEVE-GEAESISSLCSQIT---SAFST 340          
BLAST of PID domain-containing protein vs. UniProt/SwissProt
Match: sp|P49757|NUMB_HUMAN (Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2)

HSP 1 Score: 250.751 bits (639), Expect = 2.660e-73
Identity = 136/294 (46.26%), Postives = 183/294 (62.24%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHP---------------PAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         ++QD + A   + +  S   P                A  ++  N+  A  +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHA--IPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTD 310          
BLAST of PID domain-containing protein vs. UniProt/SwissProt
Match: sp|Q2LC84|NUMB_RAT (Protein numb homolog OS=Rattus norvegicus OX=10116 GN=Numb PE=1 SV=2)

HSP 1 Score: 250.366 bits (638), Expect = 2.950e-73
Identity = 149/328 (45.43%), Postives = 198/328 (60.37%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHPPAINA--------------ISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFST 1016
            ++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK ++A+L+VS D +RV DE +K LIVDQTIEKVSFC+PDRN  + F+YICRDGTTRRW+CH F+AVK+TGERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         +LQD + A   + +   P   P  +A               S        +PR HA +   + RQ S R FP L Q+ SPFKR+LSLR+ E+PS+  + +D   I+ T+ + E    E ISS   +I+   SAFST
Sbjct:   20 SRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVG--PSVAPGNSAPSPSSPTSPTLDPTASLEMNNPHAIPRRHAPIEQLA-RQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFP-IKNTVPEVE-GEAESISSLCSQIT---SAFST 339          
BLAST of PID domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9XTY6|NUMB1_CAEEL (Numb-related protein 1 OS=Caenorhabditis elegans OX=6239 GN=num-1 PE=1 SV=1)

HSP 1 Score: 248.054 bits (632), Expect = 6.749e-73
Identity = 147/309 (47.57%), Postives = 183/309 (59.22%), Query Frame = 3
Query:  156 WQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDE-ISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTI-------------------LENKALQGKSG-------------SFRQ-ASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSP-FKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPI---NEEPI 968
            WQ DE  VR G C F VKYLG +EV++SRGMQVCE ALK+L+  ++K ++A+LYVSGD +RV D+  S+GL+VDQTIEKVSFC+PDR   KGFAYICRDG +RRWMCH FLA KETGERLSHAVGCAF+ICLEKK++R+ E AQ  +                    E+   +G S              SFR+  S+ +R  DPQS II E  AS+  H   I  IS         PRP  +   F  RQ SLR  P +  SS  FKR +SLR      +      K++   T L  EPI   +E+P+
Sbjct:   94 WQPDEGAVRTGTCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQSVIINEVPASN--HMDEIRRIS--------KPRPTGNPALFL-RQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTERSPEKKSF--GTQLYNEPIYEGDEDPL 389          
BLAST of PID domain-containing protein vs. TrEMBL
Match: A0A0X3NTD5 (PID domain-containing protein (Fragment) OS=Schistocephalus solidus OX=70667 GN=TR155852 PE=4 SV=1)

HSP 1 Score: 343.199 bits (879), Expect = 1.901e-108
Identity = 176/275 (64.00%), Postives = 205/275 (74.55%), Query Frame = 3
Query:  126 DEDPNNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAE-PLAS----SPPHPPAIN--AISPNH------------TRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSS 893
            D   ++KP  W EDE+K++EG CSF VKYLG IEVF+SRGMQVCEEA+KALR+ KKK+ RAILYVSGD +RVSDEIS+ LIVDQTIEKVSFC+PDR H+KGFAYICRDG TRRWMCHAFLAVKE+GERLSHAVGCAFAICLEKKQKRE E  Q T     A   +  SFRQA+L+ERL DPQS I+ E PLA+    SP   P+    A+ P +             R   +PRP AS +   ERQTSLR+FPKLQE+SPFK+ LSLR+ E+P S
Sbjct:   16 DLGDSSKPQVWIEDEKKIKEGSCSFHVKYLGCIEVFESRGMQVCEEAIKALRKSKKKSQRAILYVSGDALRVSDEISQHLIVDQTIEKVSFCAPDRGHEKGFAYICRDGATRRWMCHAFLAVKESGERLSHAVGCAFAICLEKKQKREREAVQVTYPTEDATFARMSSFRQATLSERLFDPQSTILVEPPLAAGERKSPSSGPSATSRALVPYNESATAAAADHATLRPGAIPRPRASPSLI-ERQTSLRLFPKLQETSPFKQSLSLRMTEMPPS 289          
BLAST of PID domain-containing protein vs. TrEMBL
Match: A0A4Z2D800 (Protein numb OS=Schistosoma japonicum OX=6182 GN=EWB00_003539 PE=4 SV=1)

HSP 1 Score: 344.739 bits (883), Expect = 2.862e-107
Identity = 168/278 (60.43%), Postives = 210/278 (75.54%), Query Frame = 3
Query:  144 KPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAEPLA----SSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEP 965
            KP  W +DE K++EG CSFQVKYLG IEV++SRGMQVCEEA+KALR+ KKK  +A+L VSGD +RVSD++S+ LIVDQTIEKVSFC+PDRNH+KGFAYICRDG TRRWMCHAFLAVKE+GERLSHAVGCAFAICLEKKQ+RE +  Q    +++ +  + GSFR A+L ERL DPQS I A+P+     SSP     +N ++   +    +PRPHAS +   ERQ SLR+FPKLQE+SPFKR+LSLRL  +PS+  + +        +++  PI EEP
Sbjct:   26 KPQQWLDDEVKIKEGFCSFQVKYLGNIEVYESRGMQVCEEAIKALRKSKKKPQKAVLSVSGDALRVSDDVSQHLIVDQTIEKVSFCAPDRNHEKGFAYICRDGATRRWMCHAFLAVKESGERLSHAVGCAFAICLEKKQRRERDALQLEASDDRPIFTRVGSFRPATLAERLLDPQSTITADPVPQSHNSSPTSSTIMNRVASPVSHVGAIPRPHASPSII-ERQGSLRIFPKLQENSPFKRDLSLRLEGVPSNLRRLTG-------MIQGAPIAEEP 295          
BLAST of PID domain-containing protein vs. TrEMBL
Match: A0A0B7BNJ9 (PID domain-containing protein (Fragment) OS=Arion vulgaris OX=1028688 GN=ORF204228 PE=4 SV=1)

HSP 1 Score: 338.576 bits (867), Expect = 8.585e-107
Identity = 201/417 (48.20%), Postives = 254/417 (60.91%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQG--KSGSFRQASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQE-SSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFSTFTKSLCASDNSANDSPAHTMXXXXXXXXXXXXITQLQSNPFLAGAINYGASSNYASQEAISIPD-VMKNEKYVPNEESSPTIKESFQKVNLTNVPTSHPLTLSVNGFTGTSSSE-ATLINW 1373
            +KP  WQEDE+KVREG CSFQV+YLGYIEVFDSRGM +CEEA+K L+ + K K  RA+LYVSGD +RV DEISK +IVDQTIEKVSFC+PDRNH+KGFAYICRDGTTRRWMCH FLAVKE+GERLSHAVGCAFAICLEKKQKR+ E    T+  N++     ++GSFRQ +LTER+ DPQSAI+A+P+       P   + +P       V RPHA+     ERQ S R F KLQE SSPFKR LSLRL+++PS             T+ +   + E P  +    + G +   +              DS A            +  +T L S    +G  N GA  ++A     S+P     N   +  + ++PT+ ++FQ V       S P+T   N + GTSSS+ AT   W
Sbjct:   21 SKPHQWQEDEKKVREGTCSFQVRYLGYIEVFDSRGMHICEEAVKTLKSQCKGKYQRAVLYVSGDALRVVDEISKSMIVDQTIEKVSFCAPDRNHEKGFAYICRDGTTRRWMCHGFLAVKESGERLSHAVGCAFAICLEKKQKRDKETG-VTVTYNQSRTSFERTGSFRQTTLTERIVDPQSAILADPV-------PVRTSNNP-----FAVQRPHATANLL-ERQGSFRGFEKLQETSSPFKRTLSLRLSDLPS-------------TLQRQNAVLESPTQNGNGAVGGTIPEVT----------QEQEDSIAQMC------QQLTQGLTALTSEDPFSGVPNQGAGRSHALTHQASLPTPFHSNHAMLTRQHTTPTV-QTFQSV-------SQPVT---NPWGGTSSSQFATPTTW 383          
BLAST of PID domain-containing protein vs. TrEMBL
Match: A0A4E0REF0 (Putative adaptor protein numb OS=Fasciola hepatica OX=6192 GN=D915_003257 PE=4 SV=1)

HSP 1 Score: 342.428 bits (877), Expect = 1.209e-105
Identity = 173/307 (56.35%), Postives = 218/307 (71.01%), Query Frame = 3
Query:  126 DEDPNNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTR----------ASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFST 1016
            D   ++KP  W +DE K+++GCCSFQVKYLG IEV++SRGMQVCEEA+KALR+ KKK  +AILYVSGD +RVSD++S+ LIVDQTIEKVSFC+PDR H+KGFAYICRDG TRRWMCHAFLAVKE+GERLSHAVGCAFAICLEKKQKRE +  QS   +++ L  + GSFR ASL ERL DPQS ++ EPL+S+       N I+ +             A  +PRP  S +  ++RQ SLR+FPKL + SPFKR+LSLRL E+PS+  +          +   +PI EE  +     +S  +S+ ST
Sbjct:   19 DNADSSKPQQWLDDEAKIKDGCCSFQVKYLGNIEVYESRGMQVCEEAIKALRKSKKKPQKAILYVSGDALRVSDDVSQHLIVDQTIEKVSFCAPDRGHEKGFAYICRDGATRRWMCHAFLAVKESGERLSHAVGCAFAICLEKKQKRERDALQSASSDDRGLT-RVGSFRPASLAERLIDPQSTMLTEPLSSAGDARQNANGITQSQISFSSPASPANLAGAIPRPRPSPS-ITDRQGSLRLFPKLHDVSPFKRDLSLRLEELPSNIQR-------LARVTNGDPIPEETGTEIDESLSKLMSSVST 316          
BLAST of PID domain-containing protein vs. TrEMBL
Match: A0A182ZN86 (PID domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106074180 PE=4 SV=2)

HSP 1 Score: 338.191 bits (866), Expect = 2.204e-105
Identity = 169/256 (66.02%), Postives = 197/256 (76.95%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQS-TILENKALQGKSGSFRQASLTERLQDPQSAIIAEPL---ASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQE-SSPFKRELSLRLAEIPSS 893
            +KP  WQEDE+KVREG CSFQV+YLGYIEVFDSRGM +CEEA+KAL+  K K  RA+LYVSGD +RV DEISK +IVDQTIEKVSFC+PDRNH+KGFAYICRDGTTRRWMCH FLAVKE+GERLSHAVGCAFAICLEKKQKR+ E   + T  +++    ++GSFRQ +LTER+ DPQSAI+AEP+   A+S P+                V RPHA+     ERQ S R F KLQE SSPFKR LSLRL E+PS+
Sbjct:   38 SKPHQWQEDEKKVREGTCSFQVRYLGYIEVFDSRGMHICEEAVKALKSCKGKYQRAVLYVSGDALRVVDEISKSMIVDQTIEKVSFCAPDRNHEKGFAYICRDGTTRRWMCHGFLAVKESGERLSHAVGCAFAICLEKKQKRDKETGVTVTYNQSRTCFERTGSFRQTTLTERIVDPQSAILAEPVPLRAASNPY---------------AVQRPHATPNLL-ERQGSFRGFEKLQEVSSPFKRTLSLRLNELPST 277          
BLAST of PID domain-containing protein vs. Ensembl Cavefish
Match: numbl (NUMB like endocytic adaptor protein [Source:NCBI gene;Acc:103028067])

HSP 1 Score: 264.618 bits (675), Expect = 2.919e-80
Identity = 136/274 (49.64%), Postives = 183/274 (66.79%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQAS---------LTERLQDPQSAI------IAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR+G C+F V+YLG +EV +SRGM VCEEA+K L+   KKT++A+L+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN+ K F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQ+RE E   +   + ++    + GSFR +S         L ++LQD + A+         P  +SPP   A            V+PR HA +     RQ S R FP L Q++SPFKR+LSLRL ++PS+  + +D
Sbjct:   20 SRPHQWQADEEAVRKGKCNFAVRYLGLVEVEESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWICHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVSSAGQQGDREDLMKQLQDKKKAVEPCCIPAVPPGNASPPEGAATQVDRTEMGGPHVIPRRHAPLEQLV-RQGSFRGFPALSQKNSPFKRQLSLRLNDLPSTLQRKTD 292          
BLAST of PID domain-containing protein vs. Ensembl Cavefish
Match: numbl (NUMB like endocytic adaptor protein [Source:NCBI gene;Acc:103028067])

HSP 1 Score: 263.848 bits (673), Expect = 2.210e-79
Identity = 136/274 (49.64%), Postives = 183/274 (66.79%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQAS---------LTERLQDPQSAI------IAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR+G C+F V+YLG +EV +SRGM VCEEA+K L+   KKT++A+L+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN+ K F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQ+RE E   +   + ++    + GSFR +S         L ++LQD + A+         P  +SPP   A            V+PR HA +     RQ S R FP L Q++SPFKR+LSLRL ++PS+  + +D
Sbjct:   20 SRPHQWQADEEAVRKGKCNFAVRYLGLVEVEESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWICHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVSSAGQQGDREDLMKQLQDKKKAVEPCCIPAVPPGNASPPEGAATQVDRTEMGGPHVIPRRHAPLEQLV-RQGSFRGFPALSQKNSPFKRQLSLRLNDLPSTLQRKTD 292          
BLAST of PID domain-containing protein vs. Ensembl Cavefish
Match: numbl (NUMB like endocytic adaptor protein [Source:NCBI gene;Acc:103028067])

HSP 1 Score: 264.233 bits (674), Expect = 2.743e-79
Identity = 136/274 (49.64%), Postives = 183/274 (66.79%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQAS---------LTERLQDPQSAI------IAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR+G C+F V+YLG +EV +SRGM VCEEA+K L+   KKT++A+L+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN+ K F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQ+RE E   +   + ++    + GSFR +S         L ++LQD + A+         P  +SPP   A            V+PR HA +     RQ S R FP L Q++SPFKR+LSLRL ++PS+  + +D
Sbjct:   42 SRPHQWQADEEAVRKGKCNFAVRYLGLVEVEESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWICHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVSSAGQQGDREDLMKQLQDKKKAVEPCCIPAVPPGNASPPEGAATQVDRTEMGGPHVIPRRHAPLEQLV-RQGSFRGFPALSQKNSPFKRQLSLRLNDLPSTLQRKTD 314          
BLAST of PID domain-containing protein vs. Ensembl Cavefish
Match: numb (NUMB endocytic adaptor protein [Source:NCBI gene;Acc:103042920])

HSP 1 Score: 263.077 bits (671), Expect = 6.994e-79
Identity = 145/332 (43.67%), Postives = 200/332 (60.24%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHPPAINA------------ISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFSTFTKSLCASDNSANDSP 1064
            +++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+   KK +RA+L+VS D +RV D+ +K LI+DQTIEKVSFC+PDRN ++ F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQKRE E   +   + N+    + GSFR  + TE         +LQD +    +E +  +P +   I A            + P  +    +PR HA V   + RQ S R FP L Q++SPFKR++SLR+ ++PS+  + SD                 PI +   E+ G + + S    SLC    SA   P
Sbjct:   19 SSRPHQWQTDEEAVRSGKCSFAVKYLGHVEVEESRGMHICEDAVKRLKTAGKKAVRAVLWVSADGLRVVDDKTKDLILDQTIEKVSFCAPDRNFERAFSYICRDGTTRRWICHCFMAIKDSGERLSHAVGCAFAACLERKQKREKECGVTATFDANRTTFTREGSFRVTTATEQAEREEVMRQLQDAKKD--SEGVTVTPGNNTVIPATVSSPSSSPPLTMGPQESNPHAIPRRHAPVEALA-RQGSFRGFPALSQKTSPFKRQMSLRMNDLPSTMQRKSDF----------------PIKNTVPEVEGEVDSIS----SLCTQITSAFSGP 327          
BLAST of PID domain-containing protein vs. Ensembl Cavefish
Match: numbl (NUMB like endocytic adaptor protein [Source:NCBI gene;Acc:103028067])

HSP 1 Score: 263.077 bits (671), Expect = 2.386e-78
Identity = 136/274 (49.64%), Postives = 183/274 (66.79%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQAS---------LTERLQDPQSAI------IAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR+G C+F V+YLG +EV +SRGM VCEEA+K L+   KKT++A+L+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN+ K F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQ+RE E   +   + ++    + GSFR +S         L ++LQD + A+         P  +SPP   A            V+PR HA +     RQ S R FP L Q++SPFKR+LSLRL ++PS+  + +D
Sbjct:  104 SRPHQWQADEEAVRKGKCNFAVRYLGLVEVEESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWICHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVSSAGQQGDREDLMKQLQDKKKAVEPCCIPAVPPGNASPPEGAATQVDRTEMGGPHVIPRRHAPLEQLV-RQGSFRGFPALSQKNSPFKRQLSLRLNDLPSTLQRKTD 376          
BLAST of PID domain-containing protein vs. Ensembl Sea Lamprey
Match: numb (NUMB endocytic adaptor protein [Source:ZFIN;Acc:ZDB-GENE-060422-1])

HSP 1 Score: 248.054 bits (632), Expect = 7.623e-74
Identity = 142/320 (44.38%), Postives = 195/320 (60.94%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVK--YLGYIEVFDSRGMQVCEEALKAL------RRP--------KKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAI---------IAEPLAS-SPPHPPAINAISPNHTRAS---VVPRPHASVTFFSERQTSLRMFPK-LQESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSD 977
            +++P  WQ DE  VR G CSF VK  YLG +EV +SRGM VCE+A+K L      RR          +  +RA+L+VS D +RV  +++K LIVDQTIEKVSFC+PDRN+++ F+YICRDGTTRRW+CH+F+AVK++GERLSHAVGCAFA CLE+KQKRE E   +   + ++    + GSFR  + TE         ++++ + A+         +  P A+ SPP P  I  +    +       +PR HA +     RQ S R FP  LQ+SSPFKR LSLRL ++PS+  + +D   + K      P + EP S+D
Sbjct:   19 SSRPHQWQTDEEAVRHGQCSFPVKVQYLGAVEVDESRGMHVCEDAVKRLKSSTGNRRSISGFLDVVGRTKVRAVLWVSADALRVVADLTKDLIVDQTIEKVSFCAPDRNYERAFSYICRDGTTRRWLCHSFMAVKDSGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTSFTREGSFRVMTATEQAERQEALRQIEEQKRAVKIKITVKTSLTTPFATPSPPLPTTIKCMIAGPSDGGSVLAIPRRHAPIDELV-RQGSFRGFPALLQKSSPFKRNLSLRLNDLPSTLQRKTDFQLLNKVPEVESPNSPEPPSAD 337          
BLAST of PID domain-containing protein vs. Ensembl Sea Lamprey
Match: numb (NUMB endocytic adaptor protein [Source:ZFIN;Acc:ZDB-GENE-060422-1])

HSP 1 Score: 200.29 bits (508), Expect = 7.053e-58
Identity = 118/269 (43.87%), Postives = 163/269 (60.59%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKET-GERLSHAVGCAFAICLEKKQKRESEVA-QSTILENKALQGKSGSFRQASLTERLQDPQ------------------------SAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSL 869
             +P  W+ DE  VR   C F VKYLG +EV  SRG+ VCEEA+K L+   KK +RA+L+V  + +R+ DE +K LI+DQTIEKVSFC+PD  +++ F+YICR+ TT RW+CH+FLA +++ GERLSHAVGCAFA CLE+K++RE   +  +T  E++    + GSFR  S TE  +  +                         +    P  S PP   ++  +  +      +PR HA +   + RQ SLR FPKLQ+SSPFKR+LSL
Sbjct:   22 RRPAQWEIDENNVRTEGCHFFVKYLGCVEVQQSRGIHVCEEAVKKLKSSGKK-VRAVLFVCPEQLRLVDEDTKDLIMDQTIEKVSFCAPDPRNERAFSYICRECTTLRWLCHSFLARRDSQGERLSHAVGCAFAECLERKRQRELGCSVTATFDESRTTFSREGSFRVPSATELARQVRVFRAIAAARIIAEGAARGGSSGGAGSGGGSPGGSLPPRSNSMGGLGRSEL-PHAIPRRHAPLEELA-RQGSLRNFPKLQQSSPFKRQLSL 287          
BLAST of PID domain-containing protein vs. Ensembl Sea Lamprey
Match: numbl (NUMB like endocytic adaptor protein [Source:ZFIN;Acc:ZDB-GENE-051113-340])

HSP 1 Score: 136.346 bits (342), Expect = 1.017e-34
Identity = 58/97 (59.79%), Postives = 74/97 (76.29%), Query Frame = 3
Query:  363 LIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLT 650
            LIVDQ IEKVSFC+PDRN ++ F+YICRDGTTRRWMCH F+A +++GERLSHAVGCAF +CLE+KQ+RE E   +   + ++    + GSFR    T
Sbjct:    3 LIVDQLIEKVSFCAPDRNLERAFSYICRDGTTRRWMCHCFMAARDSGERLSHAVGCAFTVCLERKQRREKECGVTATFDVDRTSFMREGSFRGGRAT 99          
BLAST of PID domain-containing protein vs. Ensembl Sea Lamprey
Match: gulp1a (GULP PTB domain containing engulfment adaptor 1a [Source:NCBI gene;Acc:368404])

HSP 1 Score: 67.0106 bits (162), Expect = 1.405e-12
Identity = 54/194 (27.84%), Postives = 92/194 (47.42%), Query Frame = 3
Query:  153 SWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAIC----LEKKQKRESEVAQSTILENKA--LQGKSGSFRQA--SLTERLQDPQSAIIAE 689
            SW      +   C S+ VKYLG  EV   +G +V ++A++ L+          +K  +  L VS   + + D  SK    +  + ++SFC+ D+  K+  A+IC+D  T +  C AF + K + E ++ ++G AF +     LE   K      Q   L+ +   LQ ++G  ++    L ERL+  Q  +  E
Sbjct:   12 SWIHTPEMLTMSCVSYSVKYLGSCEVSQPKGSEVVKDAVRKLKFACHLKKSEGQKLPKVELQVSIRGVEILDPKSKESQHNCPLHRISFCADDKTDKRILAFICKDAETDQHFCFAFDSEK-SAEEITLSIGQAFDLAYRKFLESGGKDVESKKQVIALQKRVTELQTENGELQKKIEKLEERLKSTQVIVHTE 204          
BLAST of PID domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001980.1 (pep scaffold:Pmarinus_7.0:GL478958:23548:26127:-1 gene:ENSPMAG00000001797.1 transcript:ENSPMAT00000001980.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 46.9802 bits (110), Expect = 2.515e-6
Identity = 26/105 (24.76%), Postives = 56/105 (53.33%), Query Frame = 3
Query:  153 SWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR--------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYIC 443
              +E  ++ R+     + K +G  +V DSRG ++C++++  L+        R + K  R ++++S   +R+SD+ S  +  +  +EK+SF + D    + F ++C
Sbjct:   37 GLEERAQRFRDDGVRHKAKLIGVDDVSDSRGEKLCQDSMMKLKGFAAAARSRGEHKQ-RVVIHLSLSGLRISDDKSAVVEHESVLEKISFIAKDSTDTRAFGFVC 140          
BLAST of PID domain-containing protein vs. Ensembl Nematostella
Match: EDO42937 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S014])

HSP 1 Score: 175.637 bits (444), Expect = 2.858e-52
Identity = 85/145 (58.62%), Postives = 107/145 (73.79%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRP---KKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQK 563
            +++P  W+ D  KVR G  SF VKY+G IEV +SRG QVC EA + +R     KKK  R  L V+ D IRV DE +K L +DQTIEKVSFC+PD +  + F+YICR+GTTRRWMCH F+A+++TGERLSHAVGCAF  CL++KQK
Sbjct:    5 SHRPQVWENDSYKVRNGGVSFPVKYVGAIEVTESRGTQVCAEAFRKMREAGVHKKK--RMNLLVTSDCIRVVDEETKSLTIDQTIEKVSFCTPDPSDDRVFSYICREGTTRRWMCHCFIAIRDTGERLSHAVGCAFTACLQRKQK 147          
BLAST of PID domain-containing protein vs. Ensembl Nematostella
Match: EDO45363 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RT00])

HSP 1 Score: 68.9366 bits (167), Expect = 3.698e-12
Identity = 49/150 (32.67%), Postives = 73/150 (48.67%), Query Frame = 3
Query:  165 DERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKT----IRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETG---ERLSHAVGCAFAICLEKKQKR--ESEVAQS 587
            +E K R     F+ K LG  EV   RG  +C +A+K L++  K+T     + I+ V+   IR+ DE SK L+ +  I KVSF + D   KK F Y+C   T    M +A    K  G     L       F +  E  Q+R  +++V+Q+
Sbjct:   33 NEEKFRGDGVHFKCKLLGLKEVSGPRGDTICIDAIKKLKQQIKQTGEHKQKIIMAVNLRGIRILDEKSKALVYEHAINKVSFITHDPEDKKIFGYVCSQATGH--MLYAIKYDKVAGVITATLYELFQVVFKLRQEAAQRRNAQNDVSQA 180          
BLAST of PID domain-containing protein vs. Ensembl Nematostella
Match: EDO42073 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2P5])

HSP 1 Score: 57.3806 bits (137), Expect = 8.764e-9
Identity = 38/141 (26.95%), Postives = 67/141 (47.52%), Query Frame = 3
Query:  198 FQVKYLGYIEVFDSRGMQVCEEALKALRRPKK---------KTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKET-GERLSHAVGCAFAICLEKKQKRESEVAQST 590
            F VK+LG   VFD++G    ++ ++ +    K         +  + +L V    I ++D  +K   ++  I +VS+C+ D    K FA+I R+ ++R+  CH  L  KE+  + ++  V  AF +  E  Q       Q T
Sbjct:   83 FYVKWLGTRRVFDAKGSGCTDDTVREIVEEAKHLKMSHHEARLQKVLLTVYTKKITIADMETKVTKLEAPIYRVSYCTADPYFPKVFAFIVREQSSRKLYCHTVLCSKESMAKAIALTVADAFTVAYESVQNIVQRTQQET 223          
BLAST of PID domain-containing protein vs. Ensembl Nematostella
Match: EDO43144 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZG4])

HSP 1 Score: 54.6842 bits (130), Expect = 5.272e-8
Identity = 35/137 (25.55%), Postives = 66/137 (48.18%), Query Frame = 3
Query:  156 WQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRA---ILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAF-LAVKETGERLSHAVGCAFAICLEK 554
            W  +   + +G  ++  +YLG   V +  G+    +A + +R    K  +    IL +S + I+  D  S+ L+    ++ VS+ + D   K  FAYI +D    +  CH F +  KE  + ++ ++G AF +  E+
Sbjct:  243 WHHEPEVLLKGSVNYTTQYLGSHMVKEISGVTSTIDACRKMRLSTAKLQKVPSVILSISVNGIKFIDARSRLLVSHHDMKNVSYITQDPEDKCVFAYIAKDAKIDKHYCHVFRVEKKELSDEVTMSIGQAFELAYEQ 379          
BLAST of PID domain-containing protein vs. Ensembl Nematostella
Match: EDO49371 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG70])

HSP 1 Score: 50.8322 bits (120), Expect = 9.764e-8
Identity = 36/131 (27.48%), Postives = 68/131 (51.91%), Query Frame = 3
Query:  210 YLGYIEVFDSRGMQVCEEAL----------KALRRPKKKTIRAI-LYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAIC----LEKK 557
            + G  EV +++G +V +EA+          K+    K   +R + L ++ D + + D  SK ++    +  +S+C+ D+ +K+ FA+I +D T+ +  C+ F A +   E L+  VG AF +     LE+K
Sbjct:    1 FYGVTEVAEAKGTEVIKEAITKVQFANHIKKSEAGTKASKLRKVDLKINIDGVSIEDSKSKEVLHSYPLHHISYCADDKRNKRVFAFIAKDKTSPKHTCYVFEA-ERLAEELTLTVGQAFDLAYRRFLERK 130          
BLAST of PID domain-containing protein vs. Ensembl Medaka
Match: numbl (numb-like protein [Source:NCBI gene;Acc:101156908])

HSP 1 Score: 258.84 bits (660), Expect = 2.113e-78
Identity = 135/276 (48.91%), Postives = 180/276 (65.22%), Query Frame = 3
Query:  141 NKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSF---------------RQASLTERLQDPQSAIIAE--PLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            ++P  WQ DE  VR+G C+F V+YLG +EV +SRGM VCEEA+K L+   KKT++A+L+VS D +RV D+ +K LIVDQTIEKVSFC+PDRN+ K F+YICRDGTTRRWMCH F+A+K++GERLSHAVGCAFA CLE+KQ+RE E   +   + ++    + GSF               R   L E+ +  Q  ++    P A+SPP   A     P       +PR HA +     RQ S R FP L Q++SPFKR+LSLRL ++PS+  + +D
Sbjct:   20 SRPHQWQADEEAVRKGKCNFAVRYLGLVEVEESRGMHVCEEAVKKLKISGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNYDKAFSYICRDGTTRRWMCHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDASRTSFVREGSFRVNSSSSHQGSSSSERDDKLQEKKKGNQPCVVPALPPGAASPPEGAASPMERPEPGGPHAIPRRHAPIEQLV-RQGSFRGFPALSQKNSPFKRQLSLRLNDLPSTLQRKTD 294          
BLAST of PID domain-containing protein vs. Ensembl Medaka
Match: numb (NUMB endocytic adaptor protein [Source:NCBI gene;Acc:101171729])

HSP 1 Score: 255.373 bits (651), Expect = 6.582e-76
Identity = 135/283 (47.70%), Postives = 183/283 (64.66%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQ-----------SAIIAEPLASSPPHPPAINAISPNHTR---ASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            +++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+   KK +RA+L+VS D +RV D+ +K LI+DQTIEKVSFC+PDRN ++ F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQKRE E   +   + N+    + GSFR  + TE         +LQD +           +  +  PLA     P + ++  P       A  +PR HA     + RQ S R FP L Q++SPFKR +SLR+ E+PS+  + SD
Sbjct:   19 SSRPHQWQTDEEAVRGGKCSFAVKYLGHVEVEESRGMHICEDAVKRLKTAGKKAVRAVLWVSADGLRVVDDKTKDLILDQTIEKVSFCAPDRNFERAFSYICRDGTTRRWICHCFMAIKDSGERLSHAVGCAFAACLERKQKREKECGVTATFDANRTTFTREGSFRVTTATEAAEREEVMRQLQDVKKEPDATAAGDSANCVTNPLAQQSGSPASPSSSPPLSVSALGAQAIPRRHAPAEALA-RQGSFRGFPALSQKTSPFKRHMSLRMNELPSTMQRRSD 300          
BLAST of PID domain-containing protein vs. Ensembl Medaka
Match: numb (NUMB endocytic adaptor protein [Source:NCBI gene;Acc:101171729])

HSP 1 Score: 249.21 bits (635), Expect = 2.441e-74
Identity = 133/280 (47.50%), Postives = 179/280 (63.93%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            +++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK +RA+L+VS D +RV D+ +K LI+DQTIEKVSFC+PDRN ++ F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQKRE E   +   + N+    + GSFR  + TE         +LQD +         SS         +S +   A  +PR HA     + RQ S R FP L Q++SPFKR +SLR+ E+PS+  + SD
Sbjct:   19 SSRPHQWQTDEEAVRGGKCSFAVKYLGHVEVEESRGMHICEDAVKRLKTDRKFFKGFFAKAGKKAVRAVLWVSADGLRVVDDKTKDLILDQTIEKVSFCAPDRNFERAFSYICRDGTTRRWICHCFMAIKDSGERLSHAVGCAFAACLERKQKREKECGVTATFDANRTTFTREGSFRVTTATEAAEREEVMRQLQDVKKGQCVPASPSS------SPPLSVSALGAQAIPRRHAPAEALA-RQGSFRGFPALSQKTSPFKRHMSLRMNELPSTMQRRSD 291          
BLAST of PID domain-containing protein vs. Ensembl Medaka
Match: numb (NUMB endocytic adaptor protein [Source:NCBI gene;Acc:101171729])

HSP 1 Score: 247.284 bits (630), Expect = 2.481e-73
Identity = 135/294 (45.92%), Postives = 184/294 (62.59%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQ-----------SAIIAEPLASSPPHPPAINAISPNHTR---ASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            +++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK +RA+L+VS D +RV D+ +K LI+DQTIEKVSFC+PDRN ++ F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQKRE E   +   + N+    + GSFR  + TE         +LQD +           +  +  PLA     P + ++  P       A  +PR HA     + RQ S R FP L Q++SPFKR +SLR+ E+PS+  + SD
Sbjct:   19 SSRPHQWQTDEEAVRGGKCSFAVKYLGHVEVEESRGMHICEDAVKRLKTDRKFFKGFFAKAGKKAVRAVLWVSADGLRVVDDKTKDLILDQTIEKVSFCAPDRNFERAFSYICRDGTTRRWICHCFMAIKDSGERLSHAVGCAFAACLERKQKREKECGVTATFDANRTTFTREGSFRVTTATEAAEREEVMRQLQDVKKEPDATAAGDSANCVTNPLAQQSGSPASPSSSPPLSVSALGAQAIPRRHAPAEALA-RQGSFRGFPALSQKTSPFKRHMSLRMNELPSTMQRRSD 311          
BLAST of PID domain-containing protein vs. Ensembl Medaka
Match: numb (NUMB endocytic adaptor protein [Source:NCBI gene;Acc:101171729])

HSP 1 Score: 247.669 bits (631), Expect = 4.794e-73
Identity = 135/294 (45.92%), Postives = 184/294 (62.59%), Query Frame = 3
Query:  138 NNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALR-----------RPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILE-NKALQGKSGSFRQASLTE---------RLQDPQ-----------SAIIAEPLASSPPHPPAINAISPNHTR---ASVVPRPHASVTFFSERQTSLRMFPKL-QESSPFKRELSLRLAEIPSSSSKGSD 911
            +++P  WQ DE  VR G CSF VKYLG++EV +SRGM +CE+A+K L+           +  KK +RA+L+VS D +RV D+ +K LI+DQTIEKVSFC+PDRN ++ F+YICRDGTTRRW+CH F+A+K++GERLSHAVGCAFA CLE+KQKRE E   +   + N+    + GSFR  + TE         +LQD +           +  +  PLA     P + ++  P       A  +PR HA     + RQ S R FP L Q++SPFKR +SLR+ E+PS+  + SD
Sbjct:   19 SSRPHQWQTDEEAVRGGKCSFAVKYLGHVEVEESRGMHICEDAVKRLKTDRKFFKGFFAKAGKKAVRAVLWVSADGLRVVDDKTKDLILDQTIEKVSFCAPDRNFERAFSYICRDGTTRRWICHCFMAIKDSGERLSHAVGCAFAACLERKQKREKECGVTATFDANRTTFTREGSFRVTTATEAAEREEVMRQLQDVKKEPDATAAGDSANCVTNPLAQQSGSPASPSSSPPLSVSALGAQAIPRRHAPAEALA-RQGSFRGFPALSQKTSPFKRHMSLRMNELPSTMQRRSD 311          
BLAST of PID domain-containing protein vs. Planmine SMEST
Match: SMESG000078082.1 (SMESG000078082.1)

HSP 1 Score: 1038.87 bits (2685), Expect = 0.000e+0
Identity = 515/517 (99.61%), Postives = 516/517 (99.81%), Query Frame = 3
Query:  120 CQDEDPNNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFSTFTKSLCASDNSANDSPAHTMXXXXXXXXXXXXITQLQSNPFLAGAINYGASSNYASQEAISIPDVMKNEKYVPNEESSPTIKESFQKVNLTNVPTSHPLTLSVNGFTGTSSSEATLINWPAKSTELNSRNVCQLGTSSTNPWWGDSPKSKPDDYSAGTVSGNPTQTLLPVSTDSTDVSKSAFTTNLDPFDISWINNSRCDENEKTNNSSWISNNPFLT 1670
            CQDEDPNNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFSTFTKSLCASDNSA+DSPAHTMSSSFAFGSQSDSITQLQSNPFLAGAINYGASSNYASQEAISIPDVMKNEKYVPNEESSPTIKESFQKVNLTNVPTSHPLTLSVNGFTGTSSSEATLINWPAKSTELNSRNVCQLGTSSTNPWWGDSPKSKPDDYSAGTVSGNPTQTLLPVS DSTDVSKSAFTTNLDPFDISWINNSRCDENEKTNNSSWISNNPFLT
Sbjct:   17 CQDEDPNNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFSTFTKSLCASDNSASDSPAHTMSSSFAFGSQSDSITQLQSNPFLAGAINYGASSNYASQEAISIPDVMKNEKYVPNEESSPTIKESFQKVNLTNVPTSHPLTLSVNGFTGTSSSEATLINWPAKSTELNSRNVCQLGTSSTNPWWGDSPKSKPDDYSAGTVSGNPTQTLLPVSADSTDVSKSAFTTNLDPFDISWINNSRCDENEKTNNSSWISNNPFLT 533          
BLAST of PID domain-containing protein vs. Planmine SMEST
Match: SMESG000078082.1 (SMESG000078082.1)

HSP 1 Score: 1009.98 bits (2610), Expect = 0.000e+0
Identity = 505/517 (97.68%), Postives = 506/517 (97.87%), Query Frame = 3
Query:  120 CQDEDPNNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPISSDQREISGRLSAFSTFTKSLCASDNSANDSPAHTMXXXXXXXXXXXXITQLQSNPFLAGAINYGASSNYASQEAISIPDVMKNEKYVPNEESSPTIKESFQKVNLTNVPTSHPLTLSVNGFTGTSSSEATLINWPAKSTELNSRNVCQLGTSSTNPWWGDSPKSKPDDYSAGTVSGNPTQTLLPVSTDSTDVSKSAFTTNLDPFDISWINNSRCDENEKTNNSSWISNNPFLT 1670
            CQDEDPNNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSKGSDK          EPINEEPISSDQREISGRLSAFSTFTKSLCASDNSA+DSPAHTMSSSFAFGSQSDSITQLQSNPFLAGAINYGASSNYASQEAISIPDVMKNEKYVPNEESSPTIKESFQKVNLTNVPTSHPLTLSVNGFTGTSSSEATLINWPAKSTELNSRNVCQLGTSSTNPWWGDSPKSKPDDYSAGTVSGNPTQTLLPVS DSTDVSKSAFTTNLDPFDISWINNSRCDENEKTNNSSWISNNPFLT
Sbjct:   17 CQDEDPNNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQESSPFKRELSLRLAEIPSSSSKGSDKD---------EPINEEPISSDQREISGRLSAFSTFTKSLCASDNSASDSPAHTMSSSFAFGSQSDSITQLQSNPFLAGAINYGASSNYASQEAISIPDVMKNEKYVPNEESSPTIKESFQKVNLTNVPTSHPLTLSVNGFTGTSSSEATLINWPAKSTELNSRNVCQLGTSSTNPWWGDSPKSKPDDYSAGTVSGNPTQTLLPVSADSTDVSKSAFTTNLDPFDISWINNSRCDENEKTNNSSWISNNPFLT 524          
BLAST of PID domain-containing protein vs. Planmine SMEST
Match: SMESG000033358.1 (SMESG000033358.1)

HSP 1 Score: 315.079 bits (806), Expect = 9.469e-101
Identity = 160/260 (61.54%), Postives = 198/260 (76.15%), Query Frame = 3
Query:  132 DPNNKPVSWQEDERKVREGCCSFQVKYLGYIEVFDSRGMQVCEEALKALRRPKKKTI--RAILYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHAVGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQSAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRMFPKLQE-SSPFKRELSLRLAEIPSSSSK 902
            D N KP  W +DE+KVREGCCSFQVKYLG IEVF+SRGM VCEEA+K L + K K    RAILYVSGD +RV++EISKGLIVDQ IEKVSFC+PDRNHK+GFAYICRD TTRRW+CH F AVKE+GERLSHAVGCAFA+CLEKKQ+RE +    T  ENK    + GSF+QA++TER  DPQS IIAEP++ S       N++       S +PRPHAS +   +RQ S+++FPKLQE ++PFKR+ S+R+ ++ S+  +
Sbjct:   22 DSNTKPSQWNDDEKKVREGCCSFQVKYLGSIEVFESRGMPVCEEAMKQLLKYKSKKKSKRAILYVSGDALRVTEEISKGLIVDQVIEKVSFCAPDRNHKRGFAYICRDATTRRWLCHGFKAVKESGERLSHAVGCAFAVCLEKKQQREKDSVDVTFNENKTSFTRLGSFKQATITERRLDPQSVIIAEPVSGSSNANSTNNSVP----TPSSIPRPHASQSVL-DRQNSMKIFPKLQEQNNPFKRDHSVRITDLSSNQER 276          
BLAST of PID domain-containing protein vs. Planmine SMEST
Match: SMESG000081425.1 (SMESG000081425.1)

HSP 1 Score: 55.8398 bits (133), Expect = 1.138e-8
Identity = 42/147 (28.57%), Postives = 73/147 (49.66%), Query Frame = 3
Query:  186 GCCSFQVKYLG--YIEVFDS-RGMQ--VCEEALKALRRPKKKTIRAI-------LYVSGDTIRVSDEISKGLIVDQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVK-ETGERLSHAVGCAFAICLEKKQKRESEVAQS 587
            G C F +KYLG   IE F +  G    V  +A+KA++  + K  + I         +    I + D ++   I++ +I+++SFC+ D  + K FAYI R+       CHAF  +  +T   +S AV  AF +  ++   +  ++ +S
Sbjct:   33 GIC-FLLKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNKGSKKISKASKVDFVIKSSGITIFDHLTGEKILESSIDRISFCTADGTYPKVFAYIARNSINETMECHAFSCINSKTAFDVSLAVNQAFHVAKDELDYKSLQIDKS 178          
The following BLAST results are available for this feature:
BLAST of PID domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NUMB4.400e-7748.06NUMB endocytic adaptor protein [Source:HGNC Symbol... [more]
NUMB6.307e-7748.06NUMB endocytic adaptor protein [Source:HGNC Symbol... [more]
NUMB6.307e-7748.06NUMB endocytic adaptor protein [Source:HGNC Symbol... [more]
NUMB2.476e-7446.26NUMB endocytic adaptor protein [Source:HGNC Symbol... [more]
NUMB2.476e-7446.26NUMB endocytic adaptor protein [Source:HGNC Symbol... [more]
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BLAST of PID domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
num-11.756e-7447.57Numb-related protein 1 [Source:UniProtKB/Swiss-Pr... [more]
num-12.726e-7447.57Numb-related protein 1 [Source:UniProtKB/Swiss-Pr... [more]
num-15.306e-7447.57Numb-related protein 1 [Source:UniProtKB/Swiss-Pr... [more]
num-19.258e-7347.57Numb-related protein 1 [Source:UniProtKB/Swiss-Pr... [more]
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BLAST of PID domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
numb2.068e-8851.87gene:FBgn0002973 transcript:FBtr0079821[more]
numb5.288e-8851.87gene:FBgn0002973 transcript:FBtr0079822[more]
numb5.288e-8851.87gene:FBgn0002973 transcript:FBtr0339526[more]
Dab1.462e-926.67gene:FBgn0000414 transcript:FBtr0330190[more]
Dab1.595e-926.67gene:FBgn0000414 transcript:FBtr0305085[more]
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BLAST of PID domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
numb9.695e-8047.67NUMB endocytic adaptor protein [Source:ZFIN;Acc:ZD... [more]
numbl1.169e-7749.46NUMB like endocytic adaptor protein [Source:ZFIN;A... [more]
numbl1.169e-7749.46NUMB like endocytic adaptor protein [Source:ZFIN;A... [more]
numbl1.298e-7749.46NUMB like endocytic adaptor protein [Source:ZFIN;A... [more]
numbl1.401e-7749.46NUMB like endocytic adaptor protein [Source:ZFIN;A... [more]
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BLAST of PID domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
numb2.277e-7948.60numb homolog [Source:NCBI gene;Acc:100038147][more]
numb2.692e-7948.60numb homolog [Source:NCBI gene;Acc:100038147][more]
numb2.711e-7646.80numb homolog [Source:NCBI gene;Acc:100038147][more]
NUMBL2.054e-7548.40numb homolog-like [Source:NCBI gene;Acc:100488844][more]
NUMBL2.698e-7548.40numb homolog-like [Source:NCBI gene;Acc:100488844][more]
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BLAST of PID domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Numb1.600e-7747.00NUMB endocytic adaptor protein [Source:MGI Symbol;... [more]
Numb3.448e-7747.00NUMB endocytic adaptor protein [Source:MGI Symbol;... [more]
Numb5.084e-7746.42NUMB endocytic adaptor protein [Source:MGI Symbol;... [more]
Numb1.426e-7445.43NUMB endocytic adaptor protein [Source:MGI Symbol;... [more]
Numb1.978e-7445.43NUMB endocytic adaptor protein [Source:MGI Symbol;... [more]
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BLAST of PID domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P16554|NUMB_DROME5.300e-8751.87Protein numb OS=Drosophila melanogaster OX=7227 GN... [more]
sp|Q9QZS3|NUMB_MOUSE1.384e-7345.43Protein numb homolog OS=Mus musculus OX=10090 GN=N... [more]
sp|P49757|NUMB_HUMAN2.660e-7346.26Protein numb homolog OS=Homo sapiens OX=9606 GN=NU... [more]
sp|Q2LC84|NUMB_RAT2.950e-7345.43Protein numb homolog OS=Rattus norvegicus OX=10116... [more]
sp|Q9XTY6|NUMB1_CAEEL6.749e-7347.57Numb-related protein 1 OS=Caenorhabditis elegans O... [more]
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BLAST of PID domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0X3NTD51.901e-10864.00PID domain-containing protein (Fragment) OS=Schist... [more]
A0A4Z2D8002.862e-10760.43Protein numb OS=Schistosoma japonicum OX=6182 GN=E... [more]
A0A0B7BNJ98.585e-10748.20PID domain-containing protein (Fragment) OS=Arion ... [more]
A0A4E0REF01.209e-10556.35Putative adaptor protein numb OS=Fasciola hepatica... [more]
A0A182ZN862.204e-10566.02PID domain-containing protein OS=Biomphalaria glab... [more]
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BLAST of PID domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
numbl2.919e-8049.64NUMB like endocytic adaptor protein [Source:NCBI g... [more]
numbl2.210e-7949.64NUMB like endocytic adaptor protein [Source:NCBI g... [more]
numbl2.743e-7949.64NUMB like endocytic adaptor protein [Source:NCBI g... [more]
numb6.994e-7943.67NUMB endocytic adaptor protein [Source:NCBI gene;A... [more]
numbl2.386e-7849.64NUMB like endocytic adaptor protein [Source:NCBI g... [more]
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BLAST of PID domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
numb7.623e-7444.38NUMB endocytic adaptor protein [Source:ZFIN;Acc:ZD... [more]
numb7.053e-5843.87NUMB endocytic adaptor protein [Source:ZFIN;Acc:ZD... [more]
numbl1.017e-3459.79NUMB like endocytic adaptor protein [Source:ZFIN;A... [more]
gulp1a1.405e-1227.84GULP PTB domain containing engulfment adaptor 1a [... [more]
ENSPMAT00000001980.12.515e-624.76pep scaffold:Pmarinus_7.0:GL478958:23548:26127:-1 ... [more]
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BLAST of PID domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of PID domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO429372.858e-5258.62Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO453633.698e-1232.67Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO420738.764e-926.95Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO431445.272e-825.55Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO493719.764e-827.48Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of PID domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
numbl2.113e-7848.91numb-like protein [Source:NCBI gene;Acc:101156908][more]
numb6.582e-7647.70NUMB endocytic adaptor protein [Source:NCBI gene;A... [more]
numb2.441e-7447.50NUMB endocytic adaptor protein [Source:NCBI gene;A... [more]
numb2.481e-7345.92NUMB endocytic adaptor protein [Source:NCBI gene;A... [more]
numb4.794e-7345.92NUMB endocytic adaptor protein [Source:NCBI gene;A... [more]
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BLAST of PID domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000078082.10.000e+099.61SMESG000078082.1[more]
SMESG000078082.10.000e+097.68SMESG000078082.1[more]
SMESG000033358.19.469e-10161.54SMESG000033358.1[more]
SMESG000081425.11.138e-828.57SMESG000081425.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30009336 ID=SMED30009336|Name=PID domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1807bp
TGGCTGATTAATTGAAACTATTCCATTTAATTCATTTTTGATTTTAAACT
TAATATTGATCATATTTTTCAATGGAAAAGTTCAAAAAGTCAATTAGTTT
TCGTAAAAAGAAAGAAAAATGCCAAGATGAAGATCCAAATAATAAACCTG
TTTCATGGCAGGAAGACGAACGAAAGGTTCGAGAAGGATGTTGCAGTTTT
CAAGTCAAGTATTTAGGCTACATTGAAGTGTTTGATTCAAGAGGTATGCA
AGTTTGCGAAGAAGCTCTTAAAGCTCTCAGACGACCAAAAAAAAAGACTA
TCCGTGCTATTCTTTATGTAAGTGGGGATACAATCAGAGTGTCAGATGAA
ATTAGCAAAGGATTAATCGTTGACCAAACAATTGAAAAAGTCTCATTTTG
CTCGCCCGATAGAAACCATAAAAAAGGGTTTGCATATATTTGCCGTGACG
GAACGACCCGTCGATGGATGTGCCATGCGTTTCTAGCAGTAAAAGAAACG
GGCGAAAGATTATCCCATGCTGTTGGCTGCGCCTTTGCAATTTGTTTAGA
AAAAAAACAAAAAAGAGAAAGTGAAGTAGCACAATCCACTATATTGGAAA
ATAAAGCATTACAAGGAAAATCTGGATCGTTTCGCCAAGCCTCATTAACA
GAACGGTTACAAGATCCACAATCAGCCATAATTGCAGAGCCTCTTGCTTC
CTCACCACCACATCCTCCGGCTATAAATGCAATTTCTCCAAATCATACTA
GAGCGTCAGTCGTCCCTAGACCTCATGCCAGTGTCACATTTTTCTCTGAA
AGACAAACTTCATTAAGAATGTTTCCCAAGCTTCAAGAATCAAGTCCGTT
TAAAAGGGAATTGTCACTGAGATTGGCAGAAATTCCATCATCGAGTTCAA
AAGGAAGTGATAAAGCTTACATTCGCAAAACTATTCTAAAATATGAGCCT
ATAAATGAAGAGCCAATATCGTCTGATCAACGAGAAATTTCAGGTCGATT
ATCTGCATTTTCTACATTCACTAAAAGTCTATGTGCTTCTGATAACTCTG
CCAATGATTCTCCAGCTCATACTATGTCTTCGTCTTTTGCTTTTGGTTCA
CAATCAGATTCCATTACTCAGTTACAAAGTAATCCTTTCCTAGCCGGTGC
AATTAATTACGGTGCGTCTTCAAACTATGCTTCCCAGGAAGCTATCAGTA
TTCCAGATGTAATGAAAAATGAAAAATATGTGCCGAACGAGGAATCTAGT
CCAACAATAAAAGAGTCATTCCAAAAAGTTAACTTAACAAATGTACCTAC
CTCACACCCTTTAACATTATCAGTGAATGGGTTTACTGGAACAAGCAGTT
CAGAGGCAACTCTTATAAATTGGCCTGCCAAATCGACTGAATTAAATTCG
AGAAATGTTTGTCAGCTTGGAACATCTTCAACAAATCCTTGGTGGGGGGA
TTCCCCTAAATCAAAACCCGATGATTATTCAGCTGGAACCGTCAGTGGGA
ATCCAACGCAAACGCTGCTGCCAGTCTCAACAGATAGTACTGATGTATCG
AAATCTGCATTTACTACAAATCTTGATCCATTTGATATCAGCTGGATTAA
CAATAGCCGTTGTGATGAAAACGAAAAAACTAATAATTCATCTTGGATTT
CAAATAATCCTTTCTTGACGTAAACTTTAGTAAACATGTCTCATTTTCTG
TTTGATATGTTTTTAATATGCTTTGATCTCAAACTGTTTATTCAAGTTTC
TTTTAACTCTTCGACTTATTTGAAACTATTTATCGGACTTGTGTTATATT
CGTCACT
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protein sequence of SMED30009336-orf-1

>SMED30009336-orf-1 ID=SMED30009336-orf-1|Name=SMED30009336-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=534bp
MEKFKKSISFRKKKEKCQDEDPNNKPVSWQEDERKVREGCCSFQVKYLGY
IEVFDSRGMQVCEEALKALRRPKKKTIRAILYVSGDTIRVSDEISKGLIV
DQTIEKVSFCSPDRNHKKGFAYICRDGTTRRWMCHAFLAVKETGERLSHA
VGCAFAICLEKKQKRESEVAQSTILENKALQGKSGSFRQASLTERLQDPQ
SAIIAEPLASSPPHPPAINAISPNHTRASVVPRPHASVTFFSERQTSLRM
FPKLQESSPFKRELSLRLAEIPSSSSKGSDKAYIRKTILKYEPINEEPIS
SDQREISGRLSAFSTFTKSLCASDNSANDSPAHTMSSSFAFGSQSDSITQ
LQSNPFLAGAINYGASSNYASQEAISIPDVMKNEKYVPNEESSPTIKESF
QKVNLTNVPTSHPLTLSVNGFTGTSSSEATLINWPAKSTELNSRNVCQLG
TSSTNPWWGDSPKSKPDDYSAGTVSGNPTQTLLPVSTDSTDVSKSAFTTN
LDPFDISWINNSRCDENEKTNNSSWISNNPFLT*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
GO:0005634nucleus
GO:0005737cytoplasm
GO:0005938cell cortex
GO:0045178basal part of cell
GO:0045180basal cortex
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR006020PTB/PI_dom
IPR010449Numb_domain
IPR011993PH-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0000166nucleotide binding
GO:0005112Notch binding
GO:0005524ATP binding
Vocabulary: biological process
TermDefinition
GO:0001709cell fate determination
GO:0007219Notch signaling pathway
GO:0007275multicellular organism development
GO:0007400neuroblast fate determination
GO:0007405neuroblast proliferation
GO:0007417central nervous system development
GO:0007419ventral cord development
GO:0007422peripheral nervous system development
GO:0007507heart development
GO:0007622rhythmic behavior
GO:0008104protein localization
GO:0008347glial cell migration
GO:0008356asymmetric cell division
GO:0008593regulation of Notch signaling pathway
GO:0009786regulation of asymmetric cell division
GO:0016360sensory organ precursor cell fate determination
GO:0035050embryonic heart tube development
GO:0042694muscle cell fate specification
GO:0045035sensory organ precursor cell division
GO:0045165cell fate commitment
GO:0045746negative regulation of Notch signaling pathway
GO:0045807positive regulation of endocytosis
GO:0050767regulation of neurogenesis
GO:0051642centrosome localization
GO:0051960regulation of nervous system development
GO:0055059asymmetric neuroblast division
GO:0061320pericardial nephrocyte differentiation
GO:0061382Malpighian tubule tip cell differentiation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR006020PTB/PI domainSMARTSM00462PTB_9coord: 1..110
e-value: 1.4E-15
score: 67.8
IPR006020PTB/PI domainPFAMPF00640PIDcoord: 15..106
e-value: 6.6E-18
score: 65.1
IPR006020PTB/PI domainPROSITEPS01179PIDcoord: 1..113
score: 20.17
IPR010449NUMB domainPFAMPF06311NumbFcoord: 172..249
e-value: 1.9E-14
score: 54.0
IPR011993PH-like domain superfamilyGENE3DG3DSA:2.30.29.30coord: 1..106
e-value: 1.7E-41
score: 143.1
NoneNo IPR availablePANTHERPTHR47368FAMILY NOT NAMEDcoord: 1..464
NoneNo IPR availableCDDcd01268PTB_Numbcoord: 1..103
e-value: 1.78837E-70
score: 218.328
NoneNo IPR availableSUPERFAMILYSSF50729PH domain-likecoord: 1..109