Dimer_Tnp_hAT domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30009329 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of Dimer_Tnp_hAT domain-containing protein vs. TrEMBL
Match: T1HS18 (Dimer_Tnp_hAT domain-containing protein OS=Rhodnius prolixus OX=13249 PE=4 SV=1) HSP 1 Score: 98.9821 bits (245), Expect = 1.034e-33 Identity = 45/76 (59.21%), Postives = 61/76 (80.26%), Query Frame = 3 Query: 2013 RVENILSKLQKEISLFEISGKKRDFLQRVYNFLLTIKPTSVESERAFSTAGLICSKIRSRLNDDTIDELCFLRSHF 2240 ++ ++ K++ EI+ FE +G K +LQ VY+FL+TI PTSVESERAFS AG IC+KIRS L+D+TID LCFLR++F Sbjct: 214 KIPSLEQKIKDEITFFEKTGTKGTYLQNVYDFLMTIVPTSVESERAFSAAGYICTKIRSSLDDETIDCLCFLRAYF 289 HSP 2 Score: 76.2554 bits (186), Expect = 1.034e-33 Identity = 56/146 (38.36%), Postives = 79/146 (54.11%), Query Frame = 2 Query: 1520 EYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQNSNINNEISLALVIRIKERRTKLISLVQYLHNGHNDSMKTTEAFAPSTNSKNKKLMLEILQRLNTTNLTDG----VIKEAATSDDIREISCNEDILHNEK 1945 E+ ++ ++ L+ +K+TVDA+CR D NL+TAD L FML L QQ S I E+ AL RI RRT+L ++QYL G D E F + K ++ + +RL NL D V++E TS I NE IL ++K Sbjct: 46 EFNLLSSIIAALTPVKLTVDALCRKDANLLTADASLTFMLNTLSQQKSTIALELLEALKSRILLRRTELSQILQYLQKGSQD---VVEVFKRISKFTIIKKIVSLTKRLTHENLEDTEDMEVVQE--TSLPIYFQISNETILESDK 186
BLAST of Dimer_Tnp_hAT domain-containing protein vs. TrEMBL
Match: T1HWC4 (Dimer_Tnp_hAT domain-containing protein OS=Rhodnius prolixus OX=13249 PE=4 SV=1) HSP 1 Score: 96.6709 bits (239), Expect = 1.927e-33 Identity = 44/76 (57.89%), Postives = 60/76 (78.95%), Query Frame = 3 Query: 2013 RVENILSKLQKEISLFEISGKKRDFLQRVYNFLLTIKPTSVESERAFSTAGLICSKIRSRLNDDTIDELCFLRSHF 2240 ++ ++ K++ EI+ FE +G K +LQ VY+FL+TI PTSVESERAFS AG IC+KIRS L+D+ ID LCFLR++F Sbjct: 181 KIPSLEQKIKDEITFFEKTGTKGTYLQNVYDFLMTIVPTSVESERAFSAAGYICTKIRSSLDDEMIDCLCFLRAYF 256 HSP 2 Score: 77.7962 bits (190), Expect = 1.927e-33 Identity = 57/151 (37.75%), Postives = 81/151 (53.64%), Query Frame = 2 Query: 1505 KMDEYEYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQNSNINNEISLALVIRIKERRTKLISLVQYLHNGHNDSMKTTEAFAPSTNSKNKKLMLEILQRLNTTNLTDG----VIKEAATSDDIREISCNEDILHNEK 1945 KM + E+ ++ ++ L+ +K+TVDA+CR D NL+TAD L FML L QQ S I E+ L RI RRT+L ++QYL G D E F + K ++ + +RL NL D V++E TS I NE IL ++K Sbjct: 8 KMTDKEFNLLSSIIAALTPVKLTVDALCRKDANLLTADASLTFMLNTLSQQKSTIALELLEVLKSRILLRRTELSQILQYLQKGSKD---VVEVFKRISKFTIIKKIVSLTKRLTHENLEDTEDMEVVQE--TSLPISFQISNETILESDK 153
BLAST of Dimer_Tnp_hAT domain-containing protein vs. TrEMBL
Match: H9JJ88 (BED-type domain-containing protein OS=Bombyx mori OX=7091 PE=4 SV=1) HSP 1 Score: 78.1814 bits (191), Expect = 4.187e-33 Identity = 58/163 (35.58%), Postives = 96/163 (58.90%), Query Frame = 2 Query: 1451 VKKLSTKALVDFHIDDSLKMDEYEYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQNSNINNEISLALVIRIKERRTKLISLVQYLHNG--HNDSMKTTE-AFAPSTNSKNKKLMLEILQRLNTTNLTDGVIKEAATSDDIREISCNEDI 1930 +K +TKAL+D ++ + E E+ + DL+ L +K+ V+ +CR D+ L+TAD L F+L+KL++Q S ++ +++ AL +RIKERRT L +V YLHN + S+K+ E F ++ + +++I +RL T G E DD + S +EDI Sbjct: 384 LKGCTTKALID--VESEITFTEDEWADIKDLLLSLQPLKLGVEVLCRRDSTLLTADTTLRFILEKLDKQQSRVSGDLATALRMRIKERRTDLSGIVLYLHNPKKYEKSVKSPEDTFLLPKKNRIRLELIKICERLLTVKEDTGRA-EGEHFDDEEDNSSDEDI 543 HSP 2 Score: 76.2554 bits (186), Expect = 4.187e-33 Identity = 35/78 (44.87%), Postives = 51/78 (65.38%), Query Frame = 3 Query: 2007 PTRVENILSKLQKEISLFEISGKKRDFLQRVYNFLLTIKPTSVESERAFSTAGLICSKIRSRLNDDTIDELCFLRSHF 2240 P + +N ++ E+ +E G K L V+ +L TI PTSVE+ERAFS G +CS IR+++ D T+D +CFLRS+F Sbjct: 566 PIKSQNFEKTIKAEMVEYENKGIKGKHLTMVHKYLNTISPTSVEAERAFSVTGYVCSPIRNKMTDRTLDTICFLRSYF 643 HSP 3 Score: 39.2762 bits (90), Expect = 4.187e-33 Identity = 18/36 (50.00%), Postives = 24/36 (66.67%), Query Frame = 3 Query: 1356 YVKIDFGKDIRLKNDCKTRRSSLLCMLERFNMLKNC 1463 Y + D GK+ L DC+T+ S+L MLERF +LK C Sbjct: 352 YAREDLGKEYGLILDCRTKWSTLYDMLERFKVLKGC 387
BLAST of Dimer_Tnp_hAT domain-containing protein vs. TrEMBL
Match: A0A4C1XQA5 (Uncharacterized protein OS=Eumeta variegata OX=151549 GN=EVAR_98391_1 PE=4 SV=1) HSP 1 Score: 79.337 bits (194), Expect = 7.447e-23 Identity = 50/141 (35.46%), Postives = 85/141 (60.28%), Query Frame = 2 Query: 1469 KALVDFHIDDSLKMDEYEYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQNSNINNEISLALVIRIKERRT-KLISLVQYLHNGHND-------SMKTTEAFAPSTNSKNKKLMLEILQRLNTTNLTD 1867 KAL+D ++ + +++ E+++V +V+VL+ IK+TV+AICR D NL TAD L F++K+L +NS + +I LV RIK+RR+ L ++ YL N D ++ F T + +K + I++RLN+ + T+ Sbjct: 186 KALID--LNHPICLEDVEFELVNKIVDVLTPIKLTVEAICRRDANLCTADAALNFLIKQLSSKNSALAKKIKTCLVDRIKQRRSDNLTGVLNYLQNPRKDEENQLLSELEWHNLFPVPTQALLRKQIKSIVKRLNSRDDTE 324 HSP 2 Score: 59.6918 bits (143), Expect = 7.447e-23 Identity = 30/53 (56.60%), Postives = 39/53 (73.58%), Query Frame = 3 Query: 1314 FK*LPTKNDNYL*NYVKIDFGKDIRLKNDCKTRRSSLLCMLERFNMLKNCLQR 1472 FK P KN+ L YVKI+ GK++ L DCKTR +SLL MLERF +LK+C+Q+ Sbjct: 134 FKRSPLKNETVLQKYVKIEHGKELSLLLDCKTRWNSLLTMLERFYLLKSCIQK 186
BLAST of Dimer_Tnp_hAT domain-containing protein vs. TrEMBL
Match: A0A4C1V2H5 (Uncharacterized protein OS=Eumeta variegata OX=151549 GN=EVAR_82851_1 PE=4 SV=1) HSP 1 Score: 77.0258 bits (188), Expect = 2.613e-22 Identity = 50/141 (35.46%), Postives = 85/141 (60.28%), Query Frame = 2 Query: 1469 KALVDFHIDDSLKMDEYEYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQNSNINNEISLALVIRIKERRT-KLISLVQYLHNGHND-------SMKTTEAFAPSTNSKNKKLMLEILQRLNTTNLTD 1867 KAL+D ++ + +++ E+++V +V+VL+ IK+TV+AICR D NL TAD L F++K+L +NS + +I LV RIK+RR+ L ++ YL N D ++ F T + +K + I++RLN+ + T+ Sbjct: 253 KALID--LNHPICLEDVEFELVNKIVDVLTPIKLTVEAICRRDANLCTADAALNFLIKQLSSKNSALAKKIKTCLVDRIKQRRSDNLTGVLNYLQNPRKDEENQLLSELEWHNLFPVLTQALLRKQIKSIVKRLNSRDDTE 391 HSP 2 Score: 59.6918 bits (143), Expect = 2.613e-22 Identity = 30/53 (56.60%), Postives = 39/53 (73.58%), Query Frame = 3 Query: 1314 FK*LPTKNDNYL*NYVKIDFGKDIRLKNDCKTRRSSLLCMLERFNMLKNCLQR 1472 FK P KN+ L YVKI+ GK++ L DCKTR +SLL MLERF +LK+C+Q+ Sbjct: 201 FKRSPLKNETVLQKYVKIEHGKELSLLLDCKTRWNSLLTMLERFYLLKSCIQK 253
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Planmine SMEST
Match: SMESG000055071.1 (SMESG000055071.1) HSP 1 Score: 244.973 bits (624), Expect = 9.165e-76 Identity = 126/169 (74.56%), Postives = 141/169 (83.43%), Query Frame = 2 Query: 1508 MDEYEYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQNSNINNEISLALVIRIKERRTKLISLVQYLHNGHNDSMKTTEAFAPSTNSKNKKLMLEILQRLNTTNLTDGVIKEAATSDDIREISCNEDILHNEKSIGEQLNQVLENDFISA*KPPNK 2014 MD+Y+YKIVLDLVNVLS K+TVD IC CD NLITA +FMLKKLE+QNSNI+N+IS ALVIR KER T+L SL QYLHNGH DS + TEAF PSTNSK+KK +LE+LQRLN T+LT GVIKE ATSDDIREISCNEDIL+NEKSIGEQLNQ LE ISA KPP + Sbjct: 1 MDKYKYKIVLDLVNVLSPFKLTVDTICLCDANLITA----KFMLKKLEKQNSNISNDISSALVIRNKERITQLSSLAQYLHNGHYDSTEMTEAFVPSTNSKSKKRILELLQRLNATDLTAGVIKEVATSDDIREISCNEDILYNEKSIGEQLNQALEKYLISARKPPTR 165
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Planmine SMEST
Match: SMESG000009273.1 (SMESG000009273.1) HSP 1 Score: 192.586 bits (488), Expect = 4.704e-66 Identity = 100/129 (77.52%), Postives = 108/129 (83.72%), Query Frame = 2 Query: 1451 VKKLSTKALVDFHIDDSLKMDEYEYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQNSNINNEISLALVIRIKERRTKLISLVQYLHNGHNDSMKTTEAFAPSTNSKNKKLMLEIL 1837 VK KALVDFHID+SLKMDEYEY IVLDLVNVLS IK+TVD ICR D NLI DI +EFMLKKLEQ+ SNI+NEIS ALVIRIK RRT+L SL QYLHNGHNDSMK T+ F PSTNSKNKKLMLE+ Sbjct: 163 VKSCIKKALVDFHIDESLKMDEYEYTIVLDLVNVLSTIKLTVDEICRRDANLIIVDIAIEFMLKKLEQKISNISNEIS-ALVIRIKGRRTQLSSLAQYLHNGHNDSMKMTKVFVPSTNSKNKKLMLELF 290 HSP 2 Score: 80.1073 bits (196), Expect = 4.704e-66 Identity = 38/55 (69.09%), Postives = 47/55 (85.45%), Query Frame = 3 Query: 1308 NIFK*LPTKNDNYL*NYVKIDFGKDIRLKNDCKTRRSSLLCMLERFNMLKNCLQR 1472 +IFK TKNDNYL YVKIDF K I LK+DCKTRRSSLLCMLE+F+M+K+C+++ Sbjct: 115 HIFKRSQTKNDNYLQKYVKIDFWKVIHLKSDCKTRRSSLLCMLEKFHMVKSCIKK 169
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Planmine SMEST
Match: SMESG000077237.1 (SMESG000077237.1) HSP 1 Score: 150.599 bits (379), Expect = 1.581e-42 Identity = 78/112 (69.64%), Postives = 91/112 (81.25%), Query Frame = 2 Query: 1508 MDEYEYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQNSNINNEISLALVIRIKERRTKLISLVQYLHNGHNDSMKTTEAFAPSTNSKNKKLMLEILQR 1843 MDEYEYKIVLD VNVLS K+T+DAI RCD NL+T DI LEF LKKLE QNS +N+ISLA+VI IK+ RT+L SL QY HNGH+DS+ TEA PSTNSKN KLML++L+R Sbjct: 1 MDEYEYKIVLDRVNVLSTFKLTLDAISRCDANLVTTDIALEFRLKKLE-QNSTTSNKISLAVVILIKD-RTQLSSLAQYFHNGHSDSINMTEASVPSTNSKNTKLMLDLLRR 110
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Planmine SMEST
Match: SMESG000049212.1 (SMESG000049212.1) HSP 1 Score: 124.79 bits (312), Expect = 3.083e-33 Identity = 59/79 (74.68%), Postives = 65/79 (82.28%), Query Frame = 3 Query: 2004 PPTRVENILSKLQKEISLFEISGKKRDFLQRVYNFLLTIKPTSVESERAFSTAGLICSKIRSRLNDDTIDELCFLRSHF 2240 P TRVEN LSKLQKE+ LF+ G K D+LQ+ YNFLL I+PT VESER FS AGL+CSKIRSRLND TID LCFLRSHF Sbjct: 37 PSTRVENTLSKLQKEMPLFKSGGTKGDYLQKFYNFLLAIRPTIVESERVFSAAGLMCSKIRSRLNDITIDALCFLRSHF 115
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Planmine SMEST
Match: SMESG000081985.1 (SMESG000081985.1) HSP 1 Score: 77.7962 bits (190), Expect = 3.447e-31 Identity = 46/144 (31.94%), Postives = 84/144 (58.33%), Query Frame = 2 Query: 1469 KALVDFHIDDSLKMDEYEYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQNSNINNEISLALVIRIKERRTKLISLVQYLHNGHNDSMKTTEAFAPSTNSKNKKLMLEILQRLNTTNLTDGVIKE-AATSD 1897 K+L+D I + + ++E++ L++ L IK+TV+A+CR D NL+T D L+FML KLE+ ++++ E+ AL I++RRT++ +QYLH G + + +E F+ T + K +++ + D ++ ATS+ Sbjct: 8 KSLID--IKSKITICDHEFEQASTLLSTLHPIKITVEALCRKDANLLTCDAALKFMLNKLEKLDNSLAKELLKALNTCIRQRRTEISGPLQYLHRGKDTFIDDSEVFSVPTRNFVKTFIVDYWTSFGLEEVADSAVQTLTATSN 149 HSP 2 Score: 77.7962 bits (190), Expect = 3.447e-31 Identity = 41/85 (48.24%), Postives = 57/85 (67.06%), Query Frame = 3 Query: 1986 LYQLENPPTRVENILSKLQKEISLFEISGKKRDFLQRVYNFLLTIKPTSVESERAFSTAGLICSKIRSRLNDDTIDELCFLRSHF 2240 L +EN P+ ++ + +E+ +FE S + LQRVYN LL I PTSV S+RAFS AG I S +R+RL++ +ID LCFLR +F Sbjct: 188 LVSIENCPSL--KFITVVGREMKIFEESSHRGPHLQRVYNDLLIIPPTSVVSDRAFSAAGTIISNLRTRLDNKSIDSLCFLRCYF 270 The following BLAST results are available for this feature:
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Dimer_Tnp_hAT domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30009329 ID=SMED30009329|Name=Dimer_Tnp_hAT domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2701bpback to top protein sequence of SMED30009329-orf-1 >SMED30009329-orf-1 ID=SMED30009329-orf-1|Name=SMED30009329-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=164bp MDEYEYKIVLDLVNVLSLIKVTVDAICRCDTNLITADIGLEFMLKKLEQQback to top Annotated Terms
The following terms have been associated with this transcript:
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