Fork head domain protein

Overview


Name	Fork head domain protein
Smed ID	SMED30009316
Length (bp)	3010

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Fork head domain protein (SMED30009316) t-SNE clustered cells

Violin plots show distribution of expression levels for Fork head domain protein (SMED30009316) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Fork head domain protein (SMED30009316) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Fork head domain protein (SMED30009316) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30009316

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30009316	h1SMcG0017675	BK013014	smed_ncbi_20240424	PMID:33536473 Pascual-Carreras et al., 2021
protonephridia	SMED30009316	h1SMcG0017675	BK013014	smed_ncbi_20240424	PMID:33536473 Pascual-Carreras et al., 2021
neuron	SMED30009316	h1SMcG0017675	BK013014	smed_ncbi_20240424	PMID:33536473 Pascual-Carreras et al., 2021
central nervous system	SMED30009316	h1SMcG0017675	BK013014	smed_ncbi_20240424	PMID:33536473 Pascual-Carreras et al., 2021
secretory cell	SMED30009316	h1SMcG0017675	BK013014	smed_ncbi_20240424	PMID:33536473 Pascual-Carreras et al., 2021
X2 cell	SMED30009316	h1SMcG0017675	SmedASXL_011997	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30009316	h1SMcG0017675	dd_Smed_v4_11337_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30009316	h1SMcG0017675	dd_Smed_v4_11337_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30009316	h1SMcG0017675	dd_Smed_v4_33493_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Fork head domain protein vs. Ensembl Human
Match: FOXN3 (forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928])

HSP 1 Score: 117.472 bits (293), Expect = 3.410e-29
Identity = 48/94 (51.06%), Postives = 67/94 (71.28%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W ++P  R NLI A++++P
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTP 207

[Close]

BLAST of Fork head domain protein vs. Ensembl Human
Match: FOXN2 (forkhead box N2 [Source:HGNC Symbol;Acc:HGNC:5281])

HSP 1 Score: 115.161 bits (287), Expect = 6.242e-28
Identity = 49/99 (49.49%), Postives = 68/99 (68.69%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGS 882
            KPP+S++ +I+MAIE SPNK + V +IY W   HFPY+  A  GWKNS+RHNLS+NK F+K+ R      G+G+ W V+P  + NLI A+++ P S  S
Sbjct:  112 KPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSVRHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLIQALKKQPFSSAS 210

[Close]

BLAST of Fork head domain protein vs. Ensembl Human
Match: FOXN2 (forkhead box N2 [Source:HGNC Symbol;Acc:HGNC:5281])

HSP 1 Score: 116.701 bits (291), Expect = 1.240e-27
Identity = 51/118 (43.22%), Postives = 74/118 (62.71%), Query Frame = 1

Query:  559 LCHSVNEYQ----------KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGS 882
            +CH +++            KPP+S++ +I+MAIE SPNK + V +IY W   HFPY+  A  GWKNS+RHNLS+NK F+K+ R      G+G+ W V+P  + NLI A+++ P S  S
Sbjct:    2 MCHPLDQLATRTQKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSVRHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLIQALKKQPFSSAS 119

[Close]

BLAST of Fork head domain protein vs. Ensembl Human
Match: FOXN3 (forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928])

HSP 1 Score: 117.472 bits (293), Expect = 6.156e-27
Identity = 52/108 (48.15%), Postives = 72/108 (66.67%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYP 909
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W ++P  R NLI A++++P      P + NT P
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTP--YHPHPHVFNTPP 219

[Close]

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYP 909
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W ++P  R NLI A++++P      P + NT P
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTP--YHPHPHVFNTPP 219

[Close]

BLAST of Fork head domain protein vs. Ensembl Celegans
Match: fkh-2 (ForKHead transcription factor family [Source:UniProtKB/TrEMBL;Acc:Q95QA9])

HSP 1 Score: 89.7373 bits (221), Expect = 1.986e-19
Identity = 43/102 (42.16%), Postives = 63/102 (61.76%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLI-----DAIRRSPCSL 876
            KPPFSY  +I MAI+ SP K +T+  IY +  T++P+Y     GW+NS+RHNLS+NK F K+ R+    PG+G YW+++    + +        +RR P SL
Sbjct:   93 KPPFSYNALIMMAIKDSPEKRLTLAGIYEYIVTNYPFYRDNKQGWQNSIRHNLSLNKCFVKVPRNF-DDPGKGNYWMLDATAEDEVFIGGATGKLRRRPSSL 193

[Close]

BLAST of Fork head domain protein vs. Ensembl Celegans
Match: fkh-6 (ForKHead transcription factor family [Source:UniProtKB/TrEMBL;Acc:Q10924])

HSP 1 Score: 85.5001 bits (210), Expect = 1.422e-17
Identity = 42/92 (45.65%), Postives = 56/92 (60.87%), Query Frame = 1

Query:  556 NLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGV----GWKNSLRHNLSINKSFKKISRDGR--GGPGRGAYW 813
            ++    N   KPP+SY  +I MAI+ SP+K MT+N IY + E  FPYY  A      GW+NS+RHNLS+N  F K +RDG+      +G YW
Sbjct:   11 HIVQEGNSIDKPPYSYVALIAMAIDASPDKRMTLNQIYKFIEAKFPYYRDADAKRKQGWQNSIRHNLSLNDCFVKKARDGQSCANDRKGNYW 102

[Close]

BLAST of Fork head domain protein vs. Ensembl Celegans
Match: fkh-10 (ForKHead transcription factor family [Source:UniProtKB/TrEMBL;Acc:O17593])

HSP 1 Score: 82.4185 bits (202), Expect = 1.436e-17
Identity = 37/80 (46.25%), Postives = 48/80 (60.00%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEP 825
            KP  SY  +I MAI +SP K M + ++Y W    +PY+   G GW+NS+RHNLS+N  F K    GR   G+G YW V P
Sbjct:   42 KPQHSYIGLIAMAILSSPQKKMVLAEVYEWIMNEYPYFRSRGAGWRNSIRHNLSLNDCFVKA---GRAANGKGHYWAVHP 118

[Close]

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEP 825
            KP  SY  +I MAI +SP K M + ++Y W    +PY+   G GW+NS+RHNLS+N  F K    GR   G+G YW V P
Sbjct:   42 KPQHSYIGLIAMAILSSPQKKMVLAEVYEWIMNEYPYFRSRGAGWRNSIRHNLSLNDCFVKA---GRAANGKGHYWAVHP 118

[Close]

BLAST of Fork head domain protein vs. Ensembl Celegans
Match: unc-130 (pep chromosome:WBcel235:II:11281986:11283953:1 gene:WBGene00006853.1 transcript:C47G2.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-130)

HSP 1 Score: 83.9593 bits (206), Expect = 4.869e-17
Identity = 37/87 (42.53%), Postives = 56/87 (64.37%), Query Frame = 1

Query:  565 HSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEP 825
            H  + + KPP+SY  +I M+I  SP K +T+++I  +    F YY +    W+NS+RHNLS+N  F K++R G G PG+G YW ++P
Sbjct:  120 HRKSSHAKPPYSYIALIAMSILNSPEKKLTLSEICEFIINKFEYYKEKFPAWQNSIRHNLSLNDCFVKVAR-GPGNPGKGNYWALDP 205

[Close]

BLAST of Fork head domain protein vs. Ensembl Fly
Match: CHES-1-like (gene:FBgn0029504 transcript:FBtr0112946)

HSP 1 Score: 116.316 bits (290), Expect = 6.561e-26
Identity = 55/105 (52.38%), Postives = 72/105 (68.57%), Query Frame = 1

Query:  559 LCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGP--GRGAYWVVEPRERNNLIDAIRRSP 867
            L H+ N   KPP+S++ +IFMAIE S  KA+ V +IY W   HFPY+  A  GWKNS+RHNLS+NKSF K+ +     P  G+G+ W VEP++R NLI A+ RSP
Sbjct:  694 LVHTNN---KPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEK----APNMGKGSLWRVEPQQRQNLIQALNRSP 791

[Close]

BLAST of Fork head domain protein vs. Ensembl Fly
Match: CHES-1-like (gene:FBgn0029504 transcript:FBtr0333203)

HSP 1 Score: 116.316 bits (290), Expect = 6.561e-26
Identity = 55/105 (52.38%), Postives = 72/105 (68.57%), Query Frame = 1

Query:  559 LCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGP--GRGAYWVVEPRERNNLIDAIRRSP 867
            L H+ N   KPP+S++ +IFMAIE S  KA+ V +IY W   HFPY+  A  GWKNS+RHNLS+NKSF K+ +     P  G+G+ W VEP++R NLI A+ RSP
Sbjct:  694 LVHTNN---KPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEK----APNMGKGSLWRVEPQQRQNLIQALNRSP 791

[Close]

BLAST of Fork head domain protein vs. Ensembl Fly
Match: CHES-1-like (gene:FBgn0029504 transcript:FBtr0071079)

HSP 1 Score: 116.316 bits (290), Expect = 6.561e-26
Identity = 55/105 (52.38%), Postives = 72/105 (68.57%), Query Frame = 1

Query:  559 LCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGP--GRGAYWVVEPRERNNLIDAIRRSP 867
            L H+ N   KPP+S++ +IFMAIE S  KA+ V +IY W   HFPY+  A  GWKNS+RHNLS+NKSF K+ +     P  G+G+ W VEP++R NLI A+ RSP
Sbjct:  694 LVHTNN---KPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEK----APNMGKGSLWRVEPQQRQNLIQALNRSP 791

[Close]

BLAST of Fork head domain protein vs. Ensembl Fly
Match: CHES-1-like (gene:FBgn0029504 transcript:FBtr0310287)

HSP 1 Score: 116.316 bits (290), Expect = 6.728e-26
Identity = 55/105 (52.38%), Postives = 72/105 (68.57%), Query Frame = 1

Query:  559 LCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGP--GRGAYWVVEPRERNNLIDAIRRSP 867
            L H+ N   KPP+S++ +IFMAIE S  KA+ V +IY W   HFPY+  A  GWKNS+RHNLS+NKSF K+ +     P  G+G+ W VEP++R NLI A+ RSP
Sbjct:  694 LVHTNN---KPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEK----APNMGKGSLWRVEPQQRQNLIQALNRSP 791

[Close]

BLAST of Fork head domain protein vs. Ensembl Fly
Match: slp1 (gene:FBgn0003430 transcript:FBtr0077499)

HSP 1 Score: 90.5077 bits (223), Expect = 3.750e-19
Identity = 40/88 (45.45%), Postives = 56/88 (63.64%), Query Frame = 1

Query:  583 QKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLI 846
            +KPP+SY  +I MAI+ SP + +T+N IY +    FPY+     GW+NS+RHNLS+NK F KI R     PG+G YW+++P      I
Sbjct:  119 KKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPR-SYDDPGKGNYWILDPSAEEVFI 205

[Close]

BLAST of Fork head domain protein vs. Ensembl Zebrafish
Match: foxn3 (forkhead box N3 [Source:ZFIN;Acc:ZDB-GENE-060512-39])

HSP 1 Score: 118.242 bits (295), Expect = 7.205e-29
Identity = 48/94 (51.06%), Postives = 68/94 (72.34%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE +P+K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R NLI A++++P
Sbjct:  114 KPPYSFSCLIFMAIEDAPSKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRQNLIQALKKTP 207

[Close]

BLAST of Fork head domain protein vs. Ensembl Zebrafish
Match: foxn3 (forkhead box N3 [Source:ZFIN;Acc:ZDB-GENE-060512-39])

HSP 1 Score: 119.398 bits (298), Expect = 6.415e-28
Identity = 48/94 (51.06%), Postives = 68/94 (72.34%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE +P+K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R NLI A++++P
Sbjct:  114 KPPYSFSCLIFMAIEDAPSKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRQNLIQALKKTP 207

[Close]

BLAST of Fork head domain protein vs. Ensembl Zebrafish
Match: ches1 (checkpoint suppressor 1 [Source:ZFIN;Acc:ZDB-GENE-040217-1])

HSP 1 Score: 118.627 bits (296), Expect = 8.981e-28
Identity = 49/100 (49.00%), Postives = 72/100 (72.00%), Query Frame = 1

Query:  568 SVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            S    +KPP+S++ +IFMAIE +P+K + V DIY W   HFPY++ A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R+NLI A++++P
Sbjct:  104 STGPSRKPPYSFSCLIFMAIEDAPSKRLPVKDIYGWILEHFPYFSSAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWSIDPDYRHNLIQALKKTP 203

[Close]

BLAST of Fork head domain protein vs. Ensembl Zebrafish
Match: ches1 (checkpoint suppressor 1 [Source:ZFIN;Acc:ZDB-GENE-040217-1])

HSP 1 Score: 118.627 bits (296), Expect = 9.791e-28
Identity = 49/100 (49.00%), Postives = 72/100 (72.00%), Query Frame = 1

Query:  568 SVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            S    +KPP+S++ +IFMAIE +P+K + V DIY W   HFPY++ A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R+NLI A++++P
Sbjct:  104 STGPSRKPPYSFSCLIFMAIEDAPSKRLPVKDIYGWILEHFPYFSSAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWSIDPDYRHNLIQALKKTP 203

[Close]

BLAST of Fork head domain protein vs. Ensembl Zebrafish
Match: FOXN2 (forkhead box N2a [Source:NCBI gene;Acc:100330010])

HSP 1 Score: 114.005 bits (284), Expect = 3.551e-27
Identity = 51/108 (47.22%), Postives = 73/108 (67.59%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRR-------SPCSLGSFP 888
            KPPFS++ +I+MAIE SP+K++ V DIY W   HFPY++ A  GWKNS+RHNLS+NK F+K+ +      G+G+ W V+P  R NLI A+++       S C+  +FP
Sbjct:  109 KPPFSFSLLIYMAIEQSPSKSLPVKDIYGWILEHFPYFSSAPTGWKNSVRHNLSLNKCFRKVEKSLGKVNGKGSLWCVDPEYRPNLIQALKKQHFPTAHSFCTPPAFP 216

[Close]

BLAST of Fork head domain protein vs. Ensembl Xenopus
Match: foxn3 (forkhead box N3 [Source:NCBI gene;Acc:549054])

HSP 1 Score: 119.783 bits (299), Expect = 1.001e-27
Identity = 49/94 (52.13%), Postives = 67/94 (71.28%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R NLI A++++P
Sbjct:  113 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRQNLIQALKKTP 206

[Close]

BLAST of Fork head domain protein vs. Ensembl Xenopus
Match: foxn3 (forkhead box N3 [Source:NCBI gene;Acc:549054])

HSP 1 Score: 119.398 bits (298), Expect = 1.082e-27
Identity = 49/94 (52.13%), Postives = 67/94 (71.28%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R NLI A++++P
Sbjct:  113 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRQNLIQALKKTP 206

[Close]

BLAST of Fork head domain protein vs. Ensembl Xenopus
Match: adgrf3 (adhesion G protein-coupled receptor F3 [Source:Xenbase;Acc:XB-GENE-959826])

HSP 1 Score: 111.309 bits (277), Expect = 3.251e-25
Identity = 47/96 (48.96%), Postives = 66/96 (68.75%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCS 873
            KPP+S++ +I+MAIE SPNK + V DIY W    FPY+  A  GWKNS+RHNLS+NK F+K+ R      G+G+ W V+P  + +LI A+++ P S
Sbjct:  108 KPPYSFSLLIYMAIEHSPNKCLPVKDIYSWILDRFPYFATAPTGWKNSVRHNLSLNKYFQKVERSHGKVNGKGSLWCVDPEYKPSLIQALKKQPFS 203

[Close]

BLAST of Fork head domain protein vs. Ensembl Xenopus
Match: ndel1 (nudE neurodevelopment protein 1 like 1 [Source:Xenbase;Acc:XB-GENE-989304])

HSP 1 Score: 103.605 bits (257), Expect = 3.609e-22
Identity = 44/92 (47.83%), Postives = 62/92 (67.39%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRR 861
            KPP+SY  +I  AI +SP K MT+++IY W   +FPYY +AG GWKNS+RHNLS+NK F K+ R  +  PG+G+YW ++   + +   A  R
Sbjct:   80 KPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYKEAGSGWKNSIRHNLSLNKCFLKVPR-SKDDPGKGSYWAIDTNPKEDAAQARPR 170

[Close]

BLAST of Fork head domain protein vs. Ensembl Xenopus
Match: ndel1 (nudE neurodevelopment protein 1 like 1 [Source:Xenbase;Acc:XB-GENE-989304])

HSP 1 Score: 103.605 bits (257), Expect = 3.634e-22
Identity = 44/92 (47.83%), Postives = 62/92 (67.39%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRR 861
            KPP+SY  +I  AI +SP K MT+++IY W   +FPYY +AG GWKNS+RHNLS+NK F K+ R  +  PG+G+YW ++   + +   A  R
Sbjct:   63 KPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYKEAGSGWKNSIRHNLSLNKCFLKVPR-SKDDPGKGSYWAIDTNPKEDAAQARPR 153

[Close]

BLAST of Fork head domain protein vs. Ensembl Mouse
Match: Foxn3 (forkhead box N3 [Source:MGI Symbol;Acc:MGI:1918625])

HSP 1 Score: 116.701 bits (291), Expect = 6.184e-27
Identity = 48/94 (51.06%), Postives = 67/94 (71.28%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W ++P  R NLI A++++P
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTP 207

[Close]

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W ++P  R NLI A++++P
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTP 207

[Close]

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W ++P  R NLI A++++P
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTP 207

[Close]

BLAST of Fork head domain protein vs. Ensembl Mouse
Match: Foxn2 (forkhead box N2 [Source:MGI Symbol;Acc:MGI:1347478])

HSP 1 Score: 110.538 bits (275), Expect = 4.199e-25
Identity = 46/96 (47.92%), Postives = 66/96 (68.75%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCS 873
            KPP+S++ +I+MAIE SPNK + V +IY W    FPY+  A  GWKNS+RHNLS+NK F+K+ R      G+G+ W V+P  + NL+ A+++ P S
Sbjct:  112 KPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDRFPYFATAPTGWKNSVRHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLMQALKKQPFS 207

[Close]

BLAST of Fork head domain protein vs. Ensembl Mouse
Match: Foxn3 (forkhead box N3 [Source:MGI Symbol;Acc:MGI:1918625])

HSP 1 Score: 100.138 bits (248), Expect = 1.753e-23
Identity = 41/78 (52.56%), Postives = 55/78 (70.51%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVV 819
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W +
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCI 191

[Close]

BLAST of Fork head domain protein vs. UniProt/SwissProt
Match: sp|Q28G71|FOXN3_XENTR (Forkhead box protein N3 OS=Xenopus tropicalis OX=8364 GN=foxn3 PE=2 SV=1)

HSP 1 Score: 119.398 bits (298), Expect = 5.734e-27
Identity = 49/94 (52.13%), Postives = 67/94 (71.28%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R NLI A++++P
Sbjct:  113 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRQNLIQALKKTP 206

[Close]

BLAST of Fork head domain protein vs. UniProt/SwissProt
Match: sp|Q3BJS3|FOXN3_XENLA (Forkhead box protein N3 OS=Xenopus laevis OX=8355 GN=foxn3 PE=2 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 1.011e-26
Identity = 48/94 (51.06%), Postives = 67/94 (71.28%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMA+E SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R NLI A++++P
Sbjct:  113 KPPYSFSCLIFMAVEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRQNLIQALKKTP 206

[Close]

BLAST of Fork head domain protein vs. UniProt/SwissProt
Match: sp|Q33BP8|FOXN3_PIG (Forkhead box protein N3 OS=Sus scrofa OX=9823 GN=FOXN3 PE=2 SV=1)

HSP 1 Score: 117.472 bits (293), Expect = 2.752e-26
Identity = 48/94 (51.06%), Postives = 67/94 (71.28%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W ++P  R NLI A++++P
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTP 207

[Close]

BLAST of Fork head domain protein vs. UniProt/SwissProt
Match: sp|O00409|FOXN3_HUMAN (Forkhead box protein N3 OS=Homo sapiens OX=9606 GN=FOXN3 PE=1 SV=1)

HSP 1 Score: 117.472 bits (293), Expect = 3.680e-26
Identity = 52/108 (48.15%), Postives = 72/108 (66.67%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYP 909
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W ++P  R NLI A++++P      P + NT P
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTP--YHPHPHVFNTPP 219

[Close]

BLAST of Fork head domain protein vs. UniProt/SwissProt
Match: sp|Q499D0|FOXN3_MOUSE (Forkhead box protein N3 OS=Mus musculus OX=10090 GN=Foxn3 PE=1 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 4.325e-26
Identity = 48/94 (51.06%), Postives = 67/94 (71.28%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SP K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ ++     G+G+ W ++P  R NLI A++++P
Sbjct:  114 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTP 207

[Close]

BLAST of Fork head domain protein vs. TrEMBL
Match: A0A0X3P2P9 (Forkhead box protein N3 (Fragment) OS=Schistocephalus solidus OX=70667 GN=FOXN3 PE=4 SV=1)

HSP 1 Score: 177.563 bits (449), Expect = 5.463e-46
Identity = 100/219 (45.66%), Postives = 127/219 (57.99%), Query Frame = 1

Query:  223 YSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITTSPVKVDVISELKSEESLYQNSTIA-DYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSL 876
            ++SGDL  L WLQ+  IL ITPLD+EE+            T   ++     LK EE+L    T+   +    +  + +           Q    SY  SS    P + G             KP +SYTH+IFMAIE++P K MTVN IY WCE +FP+Y  AG GWKNSLRHNLSINKSFK++ RDGR GPGRGAYW VEPRER NL+ A++R+P S+
Sbjct:   60 HTSGDLVSLSWLQKGNILQITPLDSEED-----------VTREGRLSTAPSLK-EETLTSGYTVCPSHITVASTGSTLPTRLSLSSTTSQVLSSSYVGSSAFSNPYSQG-----------LGKPCYSYTHLIFMAIESTPQKCMTVNQIYNWCEANFPFYKHAGAGWKNSLRHNLSINKSFKRLPRDGR-GPGRGAYWAVEPRERQNLLGAVKRNPWSV 254

[Close]

BLAST of Fork head domain protein vs. TrEMBL
Match: A0A5K3FM86 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 185.652 bits (470), Expect = 1.809e-44
Identity = 103/220 (46.82%), Postives = 131/220 (59.55%), Query Frame = 1

Query:  223 YSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDD-IISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLG 879
            ++S DL  L WLQ+  IL ITPLD+EE+  P +DD   + T +        +L  + S   NS         +    +T  + N  Y           SST             C S+    KP +SYTH+IFMAIE++P K MTVN IY WCET+FP+Y  AG GWKNSLRHNLSINKSFK++ RDGR GPGRGAYW VEPRER NL+DA++R+P ++G
Sbjct:   50 FTSSDLVSLSWLQKGDILQITPLDSEED--PSRDDRYCTKTVTETGFKHPYKLCDQSSTLSNSLCGRISIPTSASPIVTTSYVNSAY-----------SST------------YCQSL---AKPCYSYTHLIFMAIESTPAKCMTVNQIYNWCETNFPFYKHAGAGWKNSLRHNLSINKSFKRLPRDGR-GPGRGAYWAVEPRERPNLLDAVKRNPWNVG 240

[Close]

BLAST of Fork head domain protein vs. TrEMBL
Match: A0A2H1CVJ3 (Fork head domain protein OS=Fasciola hepatica OX=6192 GN=D915_001162 PE=4 SV=1)

HSP 1 Score: 180.644 bits (457), Expect = 1.508e-42
Identity = 110/262 (41.98%), Postives = 147/262 (56.11%), Query Frame = 1

Query:  211 NNYTYSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITTSPVKVDVISELKS---EESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQ--HNLC---HSVNEYQ---------KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIF 945
            N  T + GDL  L WLQ+  I+ I PLD EE++    ++  +  +S    D +S  +S   +E L       ++  +       T+ H  G         S SN S   RP ++ ++   + C   H VN +Q         KP +SYTH+IFMAIE++P K MTVN IY WCET+FP+Y QAG GWKNSLRHNLSINKSFK++ RD R GPGRGA+W VEPRER  L+DAI+R+P +  +   L       +G C  N  F
Sbjct:   53 NEPTSTPGDLVSLAWLQKGDIIQIAPLDGEEDHQSCFENSTASISSGKSDDFLSTRQSTNLDEPL-------EFSPFSVRPTVQTDSHTVG---------SVSNMSI-QRPASADAEPYSSPCVDPHVVNTHQLNLNGQGLAKPNYSYTHLIFMAIESTPQKCMTVNQIYNWCETNFPFYKQAGAGWKNSLRHNLSINKSFKRLPRDSR-GPGRGAFWTVEPRERPTLMDAIKRNPWNFANMAALV------SGQCEQNTNF 290

[Close]

BLAST of Fork head domain protein vs. TrEMBL
Match: A0A0X3PWA1 (Forkhead box protein N3 OS=Schistocephalus solidus OX=70667 GN=FOXN3 PE=4 SV=1)

HSP 1 Score: 179.104 bits (453), Expect = 3.990e-42
Identity = 100/219 (45.66%), Postives = 127/219 (57.99%), Query Frame = 1

Query:  223 YSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITTSPVKVDVISELKSEESLYQNSTIA-DYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSL 876
            ++SGDL  L WLQ+  IL ITPLD+EE+            T   ++     LK EE+L    T+   +    +  + +           Q    SY  SS    P + G             KP +SYTH+IFMAIE++P K MTVN IY WCE +FP+Y  AG GWKNSLRHNLSINKSFK++ RDGR GPGRGAYW VEPRER NL+ A++R+P S+
Sbjct:   49 HTSGDLVSLSWLQKGNILQITPLDSEED-----------VTREGRLSTAPSLK-EETLTSGYTVCPSHITVASTGSTLPTRLSLSSTTSQVLSSSYVGSSAFSNPYSQG-----------LGKPCYSYTHLIFMAIESTPQKCMTVNQIYNWCEANFPFYKHAGAGWKNSLRHNLSINKSFKRLPRDGR-GPGRGAYWAVEPRERQNLLGAVKRNPWSV 243

[Close]

BLAST of Fork head domain protein vs. TrEMBL
Match: G4VCD2 (Putative forkhead protein/ forkhead protein domain OS=Schistosoma mansoni OX=6183 GN=Smp_086270 PE=4 SV=1)

HSP 1 Score: 177.563 bits (449), Expect = 9.609e-42
Identity = 129/371 (34.77%), Postives = 182/371 (49.06%), Query Frame = 1

Query:  199 LKTNNNYTYSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIIS-ITTSP-----VKVDVISELKSEESLYQNS-TIADYYRYQAM-----RAAMTNGHQNGGYRQQHGYLSYSNSST-GVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQXXXXXXXXXXXXXXXRSVVNNKLNSSIDLQSSSRGPLLRIGGQLTDASNLIRSTPVIQRLNDSSNIIELSKTPQI----ISNSITLSTVPLIQFDQIKFESDMTTFNE 1260
            +K +++   +  DL  L WLQ+  IL I PLD EE+   G D + S +T  P      + + I  + S E +   S ++    ++  +     R A  +G Q          LS+S  S     P  +   H L        KP +SYTH+IFMAIE++P K MTVN IY WCE++FP+Y  AGVGWKNSLRHNLSINKSFK++ RD R GPGRGA+W VEPRER +L+DAI+R+P +  S   +          C+ +                           + S D+ S+S  P+ R G   +   +L+R+  + +         +L  TPQI     S+   L+T      D  KFE D+T   E
Sbjct:   21 VKHSSDLVSTPNDLVSLAWLQKRDILQIAPLDGEED---GSDSVSSPVTGRPEDEDNFETNPILHMDSLEPVVNRSPSLVPVSQFSVLDRCVRRPASVSGDQ----------LSHSEQSRFSTNPTVALGTHGLT-------KPNYSYTHLIFMAIESTPQKCMTVNQIYNWCESNFPFYKHAGVGWKNSLRHNLSINKSFKRLPRDSR-GPGRGAFWTVEPRERASLLDAIKRNPWNFASVTAM---------GCHLS---------------------------DGSHDVTSASAYPVRRFGLAHSAPGHLLRAEGLGRD--------KLESTPQIRLLYTSDGKVLATYDASFVDPSKFEYDLTAGKE 326

[Close]

BLAST of Fork head domain protein vs. Ensembl Cavefish
Match: ches1 (checkpoint suppressor 1 [Source:ZFIN;Acc:ZDB-GENE-040217-1])

HSP 1 Score: 117.087 bits (292), Expect = 4.707e-28
Identity = 48/95 (50.53%), Postives = 69/95 (72.63%), Query Frame = 1

Query:  583 QKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            +KPP+S++ +IFMAIE +P K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R+NLI A++++P
Sbjct:  113 RKPPYSFSCLIFMAIEDAPTKRLPVKDIYGWILEHFPYFASAPTGWKNSVRHNLSLNKCFKKVDKDRNQSIGKGSLWSIDPEYRHNLIQALKKTP 207

[Close]

BLAST of Fork head domain protein vs. Ensembl Cavefish
Match: foxn3 (forkhead box N3 [Source:NCBI gene;Acc:103032353])

HSP 1 Score: 119.398 bits (298), Expect = 5.581e-28
Identity = 48/94 (51.06%), Postives = 69/94 (73.40%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE +P+K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R+NLI A++++P
Sbjct:  116 KPPYSFSCLIFMAIEDAPSKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRHNLIQALKKTP 209

[Close]

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE +P+K + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R+NLI A++++P
Sbjct:  116 KPPYSFSCLIFMAIEDAPSKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRHNLIQALKKTP 209

[Close]

BLAST of Fork head domain protein vs. Ensembl Cavefish
Match: FOXN2 (forkhead box protein N2 [Source:NCBI gene;Acc:103027993])

HSP 1 Score: 113.62 bits (283), Expect = 2.607e-26
Identity = 47/92 (51.09%), Postives = 67/92 (72.83%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRR 861
            KPPFS++ +I+MAIE SP+K++ V DIY W   HFPY++ A  GWKNS+RHNLS+NK F+K+ +      G+G+ W V+P  R NLI A+++
Sbjct:  118 KPPFSFSLLIYMAIEQSPSKSLPVKDIYGWILEHFPYFSSAPTGWKNSVRHNLSLNKCFRKVEKSLGKVNGKGSLWCVDPEYRPNLIQALKK 209

[Close]

BLAST of Fork head domain protein vs. Ensembl Cavefish
Match: foxn2b (forkhead box protein N2-like [Source:NCBI gene;Acc:103026529])

HSP 1 Score: 111.309 bits (277), Expect = 1.169e-25
Identity = 46/92 (50.00%), Postives = 65/92 (70.65%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRR 861
            KPPFS++ +I+MAIE SP+K++ V DIY W   HFPY++ A  GWKNS+RHNLS+NK F+K+ R      G+G+ W V P  R  L+ A+++
Sbjct:  127 KPPFSFSLLIYMAIEQSPSKSLPVKDIYGWILEHFPYFSSAPTGWKNSVRHNLSLNKCFRKVERSLGKTNGKGSLWCVHPEFRPTLMQALKK 218

[Close]

BLAST of Fork head domain protein vs. Ensembl Sea Lamprey
Match: foxn3 (forkhead box N3 [Source:ZFIN;Acc:ZDB-GENE-060512-39])

HSP 1 Score: 108.612 bits (270), Expect = 2.008e-27
Identity = 47/98 (47.96%), Postives = 66/98 (67.35%), Query Frame = 1

Query:  574 NEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            N   KPP+S++ +IF++IE SP K + V  IY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W V+P  R NLI  ++++P
Sbjct:   59 NPNAKPPYSFSCLIFLSIEASPYKRLPVKGIYDWILDHFPYFVGAPSGWKNSVRHNLSLNKCFKKVDKDRHQSLGKGSLWCVDPDYRPNLIQTLKKAP 156

[Close]

BLAST of Fork head domain protein vs. Ensembl Sea Lamprey
Match: foxf2a (forkhead box F2a [Source:ZFIN;Acc:ZDB-GENE-110407-5])

HSP 1 Score: 94.7449 bits (234), Expect = 2.084e-23
Identity = 40/81 (49.38%), Postives = 60/81 (74.07%), Query Frame = 1

Query:  583 QKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEP 825
            +KPPFSY  +I MAI++SP K +T+++IY + +  FP++  A  GWKNS+RHNLS+N+ F K+ + G G PG+G YW ++P
Sbjct:    4 EKPPFSYIALIVMAIQSSPAKRVTLSEIYQFLQGRFPFFRGAYQGWKNSVRHNLSLNECFVKLPK-GLGRPGKGHYWTIDP 83

[Close]

BLAST of Fork head domain protein vs. Ensembl Sea Lamprey
Match: foxf2a (forkhead box F2a [Source:ZFIN;Acc:ZDB-GENE-110407-5])

HSP 1 Score: 93.5893 bits (231), Expect = 1.149e-22
Identity = 40/81 (49.38%), Postives = 60/81 (74.07%), Query Frame = 1

Query:  583 QKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEP 825
            +KPPFSY  +I MAI++SP K +T+++IY + +  FP++  A  GWKNS+RHNLS+N+ F K+ + G G PG+G YW ++P
Sbjct:    5 EKPPFSYIALIVMAIQSSPAKRVTLSEIYQFLQGRFPFFRGAYQGWKNSVRHNLSLNECFVKLPK-GLGRPGKGHYWTIDP 84

[Close]

BLAST of Fork head domain protein vs. Ensembl Sea Lamprey
Match: foxj3 (forkhead box J3 [Source:ZFIN;Acc:ZDB-GENE-101005-1])

HSP 1 Score: 101.679 bits (252), Expect = 1.531e-22
Identity = 46/102 (45.10%), Postives = 69/102 (67.65%), Query Frame = 1

Query:  562 CHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVE--PRERNNLIDAIRR 861
            C + ++  KPP+SY ++I  AI +S  K MT+++IY W   +FPYY +AG+GWKNS+RHNLS+NK F K+ R  R  PG+G+YW ++  P + N+     +R
Sbjct:   60 CSTGSKDGKPPYSYANLITFAINSSARKRMTLSEIYQWICDNFPYYKEAGIGWKNSIRHNLSLNKCFIKVPR-SRDDPGKGSYWAIDQNPSDENSSTRPKKR 160

[Close]

BLAST of Fork head domain protein vs. Ensembl Sea Lamprey
Match: FOXC2 (forkhead box C2 [Source:HGNC Symbol;Acc:HGNC:3801])

HSP 1 Score: 89.7373 bits (221), Expect = 5.269e-21
Identity = 39/84 (46.43%), Postives = 60/84 (71.43%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERN 837
            KPP+SY  +I MAI+++P+K +T+N IY +    FP+Y +   GW+NS+RHNLS+N+ F K+ RD +  PG+G+YW ++P   N
Sbjct:   77 KPPYSYIALITMAIQSAPDKKVTLNGIYQFIMDKFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDK-KPGKGSYWSLDPDSYN 159

[Close]

BLAST of Fork head domain protein vs. Ensembl Yeast
Match: HCM1 (Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative energy sources (like proline), NAD synthesis, oxidative stress resistance; key factor in early adaptation to nutrient deficiency and diauxic shift; suppressor of calmodulin mutants with specific SPB assembly defects; ortholog of C. elegans lifespan regulator PHA-4 [Source:SGD;Acc:S000000661])

HSP 1 Score: 80.8777 bits (198), Expect = 4.205e-16
Identity = 35/81 (43.21%), Postives = 49/81 (60.49%), Query Frame = 1

Query:  583 QKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEP 825
            +KPP+SY  +I +AI  S    +T++ IY W   HFPYY Q    W+NS+RHNLS+N +F K  +      G+G +W V P
Sbjct:  108 KKPPYSYATLICLAILQSQEGKLTLSQIYHWIHVHFPYYKQKDASWQNSIRHNLSLNDAFIKTEKSCD---GKGHFWEVRP 185

[Close]

BLAST of Fork head domain protein vs. Ensembl Yeast
Match: FKH2 (Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; positively regulates transcriptional elongation; facilitates clustering, activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; major role in expression of G2/M phase genes; relocalizes to cytosol under hypoxia [Source:SGD;Acc:S000005012])

HSP 1 Score: 80.4925 bits (197), Expect = 7.677e-16
Identity = 37/88 (42.05%), Postives = 55/88 (62.50%), Query Frame = 1

Query:  556 NLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVV 819
            +L H  N   KPP SY  +I  AI +SP   +++ DIY +  +++ YY  A  GW+NS+RHNLS+NK+F+K+ R     PG+G  W +
Sbjct:  330 DLSHDENRNVKPPHSYATMITQAILSSPEGVISLADIYKYISSNYAYYRFAKSGWQNSIRHNLSLNKAFEKVPRR-PNEPGKGMKWRI 416

[Close]

BLAST of Fork head domain protein vs. Ensembl Yeast
Match: FKH1 (Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; regulates transcription elongation, chromatin silencing at mating loci, expression of G2/M phase genes; facilitates clustering, activation of early-firing replication origins; binds HML recombination enhancer, regulates donor preference during mating-type switching [Source:SGD;Acc:S000001393])

HSP 1 Score: 73.1738 bits (178), Expect = 7.999e-14
Identity = 39/125 (31.20%), Postives = 65/125 (52.00%), Query Frame = 1

Query:  523 GVRPNNSGSQHN----------------LCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLID 849
            G+RPN   S  N                L    N Y KPP SY  +I  AI ++P  ++++ DIY +   ++ +Y  + + W+NS+RHNLS+NK+F+K+ +   G  G+G  W +    R + ++
Sbjct:  266 GIRPNTYTSSSNNAVTNGNVPHIENPSDLSLDENRYIKPPQSYASMITQAILSTPEGSISLADIYKFISDNYAFYRFSQMAWQNSVRHNLSLNKAFEKVPKRA-GQQGKGMNWKISDEVRRDFLN 389

[Close]

BLAST of Fork head domain protein vs. Ensembl Yeast
Match: FHL1 (Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants [Source:SGD;Acc:S000006308])

HSP 1 Score: 67.781 bits (164), Expect = 6.036e-12
Identity = 32/73 (43.84%), Postives = 49/73 (67.12%), Query Frame = 1

Query:  577 EYQ-KPPFSYTHIIFMAIET-SPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRG 789
            EY+ KP  SY+ ++   I   S  K M++++IY      FPYY     GW++S+RHNLS+NKSF+K+S++G+G
Sbjct:  457 EYRTKPTVSYSAMLTTCIRKYSTAKGMSLSEIYAGIRELFPYYKYCPDGWQSSVRHNLSLNKSFRKVSKEGKG 529

[Close]

BLAST of Fork head domain protein vs. Ensembl Nematostella
Match: EDO49084 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI36])

HSP 1 Score: 119.783 bits (299), Expect = 4.232e-32
Identity = 51/94 (54.26%), Postives = 69/94 (73.40%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            KPP+S++ +IFMAIE SPNK + V DIY W   HFPY+  A +GWKNS+RHNLS+NK FKK+ +D     G+G+ W V+P  R NL+ A+R++P
Sbjct:    2 KPPYSFSSLIFMAIEESPNKRLPVKDIYNWIMDHFPYFRDARLGWKNSVRHNLSLNKCFKKVDKDKGQNVGKGSLWTVDPDFRPNLLQALRKTP 95

[Close]

BLAST of Fork head domain protein vs. Ensembl Nematostella
Match: EDO39529 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9S2])

HSP 1 Score: 90.5077 bits (223), Expect = 1.178e-21
Identity = 44/96 (45.83%), Postives = 59/96 (61.46%), Query Frame = 1

Query:  538 NSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEP 825
            N  S+  LC  V    KPPFSY  +I M+IE SP +  T+N+IY +  T FPY+ +    W+NS+RHNLS+N  F K+ R   G PG+G YW + P
Sbjct:    4 NPQSKPYLCDEV----KPPFSYIALITMSIEASPYRMRTLNEIYEFIMTRFPYFRKNQQKWQNSIRHNLSLNDCFVKVPRSIFGKPGKGNYWTLHP 95

[Close]

BLAST of Fork head domain protein vs. Ensembl Nematostella
Match: EDO36306 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIZ2])

HSP 1 Score: 91.2781 bits (225), Expect = 2.223e-21
Identity = 42/79 (53.16%), Postives = 55/79 (69.62%), Query Frame = 1

Query:  565 HSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGR 801
            H   E  KPP+SY ++I  AI +SP K MT+++IY W   HFPYY +AG GWKNS+RHNLS+NK F K+ R  +  PG+
Sbjct:   67 HQTKE-SKPPYSYANLITFAINSSPEKKMTLSEIYQWICDHFPYYKEAGNGWKNSIRHNLSLNKCFIKVPR-SKDDPGK 143

[Close]

BLAST of Fork head domain protein vs. Ensembl Nematostella
Match: EDO47812 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL76])

HSP 1 Score: 89.3521 bits (220), Expect = 2.776e-21
Identity = 40/80 (50.00%), Postives = 56/80 (70.00%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEP 825
            KPP+SY  +I MAI  SP K +T+N IY +  + FPYY +   GW+NS+RHNLS+N+ F K+ R+G GG  +G YW ++P
Sbjct:    1 KPPYSYVALIAMAIRESPEKRLTLNGIYQYIISKFPYYEKNKKGWQNSIRHNLSLNECFIKVPREG-GGERKGNYWTLDP 79

[Close]

BLAST of Fork head domain protein vs. Ensembl Nematostella
Match: EDO35022 (Forkhead domain protein 1; Predicted protein [Source:UniProtKB/TrEMBL;Acc:Q3LUT2])

HSP 1 Score: 92.4337 bits (228), Expect = 1.608e-20
Identity = 50/125 (40.00%), Postives = 71/125 (56.80%), Query Frame = 1

Query:  469 NGGYRQQH-----GYLSYSNSSTGVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYT-QAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEP 825
            +  YR  H      +  Y N    + PN S S           QKPP+SY  +I MAI+ SP + +T+N IY +  + FPYYT Q   GW+NS+RHNLS+N+ F K+ R+ +  PG+G YW ++P
Sbjct:   17 HSAYRPFHEVENGSFKFYYNPCCPLYPNCSASTLLYKPYTPAPQKPPYSYVALISMAIKQSPGRKITLNGIYHFITSAFPYYTWQNKRGWQNSIRHNLSLNRCFVKVHRE-KADPGKGCYWTLDP 140

[Close]

BLAST of Fork head domain protein vs. Ensembl Medaka
Match: ches1 (forkhead box N3 [Source:NCBI gene;Acc:101159152])

HSP 1 Score: 121.709 bits (304), Expect = 1.239e-28
Identity = 68/184 (36.96%), Postives = 108/184 (58.70%), Query Frame = 1

Query:  316 GKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSP 867
            G D  +S++ S  K +   EL S   L++++ + + + +  +R+       +G   QQ    S S S       ++ S ++L    N  +KPP+S++ +IFMAIE +PNK + V DIY W   HFPY+  A  GWKNS+RHNLS+NK FKK+ +D     G+G+ W ++P  R+NLI A++++P
Sbjct:   42 GADLSLSVSASFSKAE-DEELTSLSWLHESTDLLNSFSHSGLRSVSPLQDPDG---QQTRSPSSSPSLDDPLLGDAHSPYDLTGGAN--RKPPYSFSCLIFMAIEDAPNKRLPVKDIYGWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWSIDPEYRHNLIQALKKTP 219

[Close]

BLAST of Fork head domain protein vs. Ensembl Medaka
Match: FOXN2 (forkhead box N2 [Source:NCBI gene;Acc:101160261])

HSP 1 Score: 113.235 bits (282), Expect = 3.710e-26
Identity = 47/92 (51.09%), Postives = 67/92 (72.83%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRR 861
            KPPFS++ +I+MAIE SP+K++ V +IY W   HFPY++ A  GWKNS+RHNLS+NK F+K+ R      G+G+ W V+P  R NLI A+++
Sbjct:  121 KPPFSFSLLIYMAIEQSPSKSLPVKEIYGWILEHFPYFSNAPTGWKNSVRHNLSLNKCFRKVDRSLGKSNGKGSLWCVDPEYRPNLIQALKK 212

[Close]

BLAST of Fork head domain protein vs. Ensembl Medaka
Match: FOXN2 (forkhead box N2 [Source:NCBI gene;Acc:101160261])

HSP 1 Score: 113.235 bits (282), Expect = 4.070e-26
Identity = 47/92 (51.09%), Postives = 67/92 (72.83%), Query Frame = 1

Query:  586 KPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRR 861
            KPPFS++ +I+MAIE SP+K++ V +IY W   HFPY++ A  GWKNS+RHNLS+NK F+K+ R      G+G+ W V+P  R NLI A+++
Sbjct:  154 KPPFSFSLLIYMAIEQSPSKSLPVKEIYGWILEHFPYFSNAPTGWKNSVRHNLSLNKCFRKVDRSLGKSNGKGSLWCVDPEYRPNLIQALKK 245

[Close]

BLAST of Fork head domain protein vs. Ensembl Medaka
Match: ENSORLT00000031716.1 (forkhead box protein J3 [Source:NCBI gene;Acc:101156973])

HSP 1 Score: 101.679 bits (252), Expect = 4.038e-24
Identity = 59/160 (36.88%), Postives = 83/160 (51.88%), Query Frame = 1

Query:  358 VDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVE--PRE 831
            V +I ++     L  + T  D+    +MRAA+    Q    R  HG                 +QH          KPP+SY  +I  AI  SP K MT+++IY W   +FPYY +AG GWKNS+RHNLS+NK F K+ R  +  PG+G+YW ++  P+E
Sbjct:   11 VHLIGQITMTSELESSLTSMDWLPQLSMRAAI----QKVDLRNHHGKKMVHLDPGTTLDQEEAAQH-------RDGKPPYSYASLITFAINGSPRKRMTLSEIYQWICDNFPYYREAGSGWKNSIRHNLSLNKCFLKVPRS-KDDPGKGSYWAIDNNPKE 158

[Close]

BLAST of Fork head domain protein vs. Ensembl Medaka
Match: si:ch211-145o7.3 (forkhead box protein N2 [Source:NCBI gene;Acc:101170028])

HSP 1 Score: 103.219 bits (256), Expect = 1.426e-23
Identity = 42/90 (46.67%), Postives = 63/90 (70.00%), Query Frame = 1

Query:  595 FSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRS 864
            +S++ +IFMAIE SP+K + V DIY W   +FPYY  A  GW+NS+RHNLS++KSF++I RD     G+G++W V P  R  L+  ++++
Sbjct:  104 YSFSSLIFMAIEDSPHKKLPVKDIYEWIVKNFPYYRSASGGWRNSVRHNLSLSKSFRRIQRDRTQSVGKGSFWCVCPEYRPALLKVLKKT 193

[Close]

BLAST of Fork head domain protein vs. Planmine SMEST
Match: SMESG000048193.1 (SMESG000048193.1)

HSP 1 Score: 1640.55 bits (4247), Expect = 0.000e+0
Identity = 907/909 (99.78%), Postives = 909/909 (100.00%), Query Frame = 1

Query:   46 MIDSNQSIYDLPYRARIMMNACIDNQKSGSNTKINHISNIENLKPMNSKSVLKTNNNYTYSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQXXXXXXXXXXXXXXXRSVVNNKLNSSIDLQSSSRGPLLRIGGQLTDASNLIRSTPVIQRLNDSSNIIELSKTPQIISNSITLSTVPLIQFDQIKFESDMTTFNESIDSNDLCSAQQDEEDCRGKVFIIDDSTESNPEFYQTYLDILRGLIYNDIEKSDSIRSENTKDCTEHLKNRKQFFSKNNCKSSDDILPIEDIAPISRKIIKKHCSLKQKRKCKCVKXXXXXXXXXXXXXNKEFSELSDTDFNSRISMGLRNQKKEKKRLYFSKLKSLTNSRKSSYNRNRINNIVRAPHSDHIYAILQEFLPPANKSEEHSPINQMIDDKESLSSTMAXXXXXXXXXXXXXXXKRXXXXXXXXXXXXXXXXXXXXXEEIFNTTNYENISNKLIRNSLSFITRKRKLNKNMNSSKIIKYNSRLLKENSEYINKKPYRKYNYDDDEERENRCYVKSEITDDTFSSPIYKSLKFEDFNNAFQGTLENLSDNKSNSYDSQFIPFKKIRPNKDTHVKRKVGRPKKSECNSVTFRYSNDLRXXXXXXXXXXXXXXTPKRDLKYLKECNSNKKVATEISNKDEQVAISVLANLQKKNQQDRIKNMYNLSNYIQRNSSDSNMS 2772
            MIDSNQSIYDLPYRARIMMNACIDNQKSGSNTKINHISNIENLKPMNSKSVLKTNNNYTYSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTG+RPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQSANTLNNNLASLTATRSVVNNKLNSSIDLQSSSRGPLLRIGGQLTDASNLIRSTPVIQRLNDSSNIIELSKTPQIISNSITLSTVPLIQFDQIKFESDMTTFNESIDSNDLCSAQQDEEDCRGKVFIIDDSTESNPEFYQTYLDILRGLIYNDIEKSDSIRSENTKDCTEHLKNRKQFFSKNNCKSSDDILPIEDIAPISRKIIKKHCSLKQKRKCKCVKSVSDSGGSDSSLSNKEFSELSDTDFNSRISMGLRNQKKEKKRLYFSKLKSLTNSRKSSYNRNRINNIVRAPHSDHIYAILQEFLPPANKSEEHSPINQMIDDKESLSSTMADDKSLSLDLSQTSLSKRSMHKLQSLKKSMKKFKFSDSDEEIFNTTNYENISNKLIRNSLSFITRKRKLNKN+NSSKIIKYNSRLLKENSEYINKKPYRKYNYDDDEERENRCYVKSEITDDTFSSPIYKSLKFEDFNNAFQGTLENLSDNKSNSYDSQFIPFKKIRPNKDTHVKRKVGRPKKSECNSVTFRYSNDLRNNKQSNIKSKKKNKTPKRDLKYLKECNSNKKVATEISNKDEQVAISVLANLQKKNQQDRIKNMYNLSNYIQRNSSDSNMS
Sbjct:    1 MIDSNQSIYDLPYRARIMMNACIDNQKSGSNTKINHISNIENLKPMNSKSVLKTNNNYTYSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGIRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQSANTLNNNLASLTATRSVVNNKLNSSIDLQSSSRGPLLRIGGQLTDASNLIRSTPVIQRLNDSSNIIELSKTPQIISNSITLSTVPLIQFDQIKFESDMTTFNESIDSNDLCSAQQDEEDCRGKVFIIDDSTESNPEFYQTYLDILRGLIYNDIEKSDSIRSENTKDCTEHLKNRKQFFSKNNCKSSDDILPIEDIAPISRKIIKKHCSLKQKRKCKCVKSVSDSGGSDSSLSNKEFSELSDTDFNSRISMGLRNQKKEKKRLYFSKLKSLTNSRKSSYNRNRINNIVRAPHSDHIYAILQEFLPPANKSEEHSPINQMIDDKESLSSTMADDKSLSLDLSQTSLSKRSMHKLQSLKKSMKKFKFSDSDEEIFNTTNYENISNKLIRNSLSFITRKRKLNKNLNSSKIIKYNSRLLKENSEYINKKPYRKYNYDDDEERENRCYVKSEITDDTFSSPIYKSLKFEDFNNAFQGTLENLSDNKSNSYDSQFIPFKKIRPNKDTHVKRKVGRPKKSECNSVTFRYSNDLRNNKQSNIKSKKKNKTPKRDLKYLKECNSNKKVATEISNKDEQVAISVLANLQKKNQQDRIKNMYNLSNYIQRNSSDSNMS 909

[Close]

BLAST of Fork head domain protein vs. Planmine SMEST
Match: SMESG000048193.1 (SMESG000048193.1)

HSP 1 Score: 1615.13 bits (4181), Expect = 0.000e+0
Identity = 878/909 (96.59%), Postives = 882/909 (97.03%), Query Frame = 1

Query:   46 MIDSNQSIYDLPYRARIMMNACIDNQKSGSNTKINHISNIENLKPMNSKSVLKTNNNYTYSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQXXXXXXXXXXXXXXXRSVVNNKLNSSIDLQSSSRGPLLRIGGQLTDASNLIRSTPVIQRLNDSSNIIELSKTPQIISNSITLSTVPLIQFDQIKFESDMTTFNESIDSNDLCSAQQDEEDCRGKVFIIDDSTESNPEFYQTYLDILRGLIYNDIEKSDSIRSENTKDCTEHLKNRKQFFSKNNCKSSDDILPIEDIAPISRKIIKKHCSLKQKRKCKCVKXXXXXXXXXXXXXNKEFSELSDTDFNSRISMGLRNQKKEKKRLYFSKLKSLTNSRKSSYNRNRINNIVRAPHSDHIYAILQEFLPPANKSEEHSPINQMIDDKESLSSTMAXXXXXXXXXXXXXXXKRXXXXXXXXXXXXXXXXXXXXXEEIFNTTNYENISNKLIRNSLSFITRKRKLNKNMNSSKIIKYNSRLLKENSEYINKKPYRKYNYDDDEERENRCYVKSEITDDTFSSPIYKSLKFEDFNNAFQGTLENLSDNKSNSYDSQFIPFKKIRPNKDTHVKRKVGRPKKSECNSVTFRYSNDLRXXXXXXXXXXXXXXTPKRDLKYLKECNSNKKVATEISNKDEQVAISVLANLQKKNQQDRIKNMYNLSNYIQRNSSDSNMS 2772
            MIDSNQSIYDLPYRARIMMNACIDNQKSGSNTKINHISNIENLKPMNSKSVLKTNNNYTYSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTG+RPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQSANTLNNNLASLTATRSVVNNKLNSSIDLQSSSRGPLLRIGGQLTDASNLIRSTPVIQRLNDSSNIIELSKTPQIISNSITLSTVPLIQFDQIKFESDMTTFNESIDSNDLCSAQQDEEDCRGKVFIIDDSTESNPEFYQTYLDILRGLIYNDIEKSDSIRSENTKDCTEHLKNRKQFFSKNNCKSSDDILPIE ++                          DSGGSDSSLSNKEFSELSDTDFNSRISMGLRNQKKEKKRLYFSKLKSLTNSRKSSYNRNRINNIVRAPHSDHIYAILQEFLPPANKSEEHSPINQMIDDKESLSSTMADDKSLSLDLSQTSLSKRSMHKLQSLKKSMKKFKFSDSDEEIFNTTNYENISNKLIRNSLSFITRKRKLNKN+NSSKIIKYNSRLLKENSEYINKKPYRKYNYDDDEERENRCYVKSEITDDTFSSPIYKSLKFEDFNNAFQGTLENLSDNKSNSYDSQFIPFKKIRPNKDTHVKRKVGRPKKSECNSVTFRYSNDLRNNKQSNIKSKKKNKTPKRDLKYLKECNSNKKVATEISNKDEQVAISVLANLQKKNQQDRIKNMYNLSNYIQRNSSDSNMS
Sbjct:    1 MIDSNQSIYDLPYRARIMMNACIDNQKSGSNTKINHISNIENLKPMNSKSVLKTNNNYTYSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGIRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQSANTLNNNLASLTATRSVVNNKLNSSIDLQSSSRGPLLRIGGQLTDASNLIRSTPVIQRLNDSSNIIELSKTPQIISNSITLSTVPLIQFDQIKFESDMTTFNESIDSNDLCSAQQDEEDCRGKVFIIDDSTESNPEFYQTYLDILRGLIYNDIEKSDSIRSENTKDCTEHLKNRKQFFSKNNCKSSDDILPIEAVS--------------------------DSGGSDSSLSNKEFSELSDTDFNSRISMGLRNQKKEKKRLYFSKLKSLTNSRKSSYNRNRINNIVRAPHSDHIYAILQEFLPPANKSEEHSPINQMIDDKESLSSTMADDKSLSLDLSQTSLSKRSMHKLQSLKKSMKKFKFSDSDEEIFNTTNYENISNKLIRNSLSFITRKRKLNKNLNSSKIIKYNSRLLKENSEYINKKPYRKYNYDDDEERENRCYVKSEITDDTFSSPIYKSLKFEDFNNAFQGTLENLSDNKSNSYDSQFIPFKKIRPNKDTHVKRKVGRPKKSECNSVTFRYSNDLRNNKQSNIKSKKKNKTPKRDLKYLKECNSNKKVATEISNKDEQVAISVLANLQKKNQQDRIKNMYNLSNYIQRNSSDSNMS 883

[Close]

BLAST of Fork head domain protein vs. Planmine SMEST
Match: SMESG000033244.1 (SMESG000033244.1)

HSP 1 Score: 201.445 bits (511), Expect = 3.291e-54
Identity = 120/301 (39.87%), Postives = 162/301 (53.82%), Query Frame = 1

Query:  235 DLQPLQWLQQDTILSITPLDNEEEY-----VPGKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQ--HNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDG-RGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQXXXXXXXXXXXXXXXRSVVNNKLNS--SIDLQSSSRGPLLRIGGQLTDASNLIRS 1107
            DLQPL WLQ+++I+ I PLD E+E       PG DD+I    S  KV+V S+        +NS I D+ R+QAMR +M N ++                   +R NNS +    N  H  + + KP  SYT +IFMAIET  ++AMTVNDIY WCE ++PYY   G  WKNSLRHNLSINKSF+++ RDG +GGPGRGAYWVV+ +ER NL+D+I R+          + T P    N                             +++   S+ +     GP+LRI G+ TDAS  ++S
Sbjct:   71 DLQPLNWLQKESIIDIDPLDIEDELKDDSNTPGYDDLIDPHISHAKVEVESQ--------ENSNIHDFVRFQAMRNSMNNSNR-----------------VALRNNNSFTDCNQNYSHQASGFAKPNLSYTQLIFMAIETCKDRAMTVNDIYQWCEVNYPYYKHIGPSWKNSLRHNLSINKSFRRMPRDGQQGGPGRGAYWVVDDKERKNLLDSIYRA----------HQTIPLSDRN---------------------------GQRIDPPYSLIVNPPKTGPMLRIDGRFTDASTYLQS 309

[Close]

BLAST of Fork head domain protein vs. Planmine SMEST
Match: SMESG000033244.1 (SMESG000033244.1)

HSP 1 Score: 192.2 bits (487), Expect = 7.686e-51
Identity = 120/326 (36.81%), Postives = 162/326 (49.69%), Query Frame = 1

Query:  235 DLQPLQWLQQDTILSITPLDNEEEY-----VPGKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQ--HNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDG--------------------------RGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQXXXXXXXXXXXXXXXRSVVNNKLNS--SIDLQSSSRGPLLRIGGQLTDASNLIRS 1107
            DLQPL WLQ+++I+ I PLD E+E       PG DD+I    S  KV+V S+        +NS I D+ R+QAMR +M N ++                   +R NNS +    N  H  + + KP  SYT +IFMAIET  ++AMTVNDIY WCE ++PYY   G  WKNSLRHNLSINKSF+++ RDG                          +GGPGRGAYWVV+ +ER NL+D+I R+          + T P    N                             +++   S+ +     GP+LRI G+ TDAS  ++S
Sbjct:   71 DLQPLNWLQKESIIDIDPLDIEDELKDDSNTPGYDDLIDPHISHAKVEVESQ--------ENSNIHDFVRFQAMRNSMNNSNR-----------------VALRNNNSFTDCNQNYSHQASGFAKPNLSYTQLIFMAIETCKDRAMTVNDIYQWCEVNYPYYKHIGPSWKNSLRHNLSINKSFRRMPRDGQTTIGNYEMNSGDDMSEETISQRDNKQGGPGRGAYWVVDDKERKNLLDSIYRA----------HQTIPLSDRN---------------------------GQRIDPPYSLIVNPPKTGPMLRIDGRFTDASTYLQS 334

[Close]

BLAST of Fork head domain protein vs. Planmine SMEST
Match: SMESG000033244.1 (SMESG000033244.1)

HSP 1 Score: 192.586 bits (488), Expect = 8.192e-51
Identity = 120/326 (36.81%), Postives = 162/326 (49.69%), Query Frame = 1

Query:  235 DLQPLQWLQQDTILSITPLDNEEEY-----VPGKDDIISITTSPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHGYLSYSNSSTGVRPNNSGSQ--HNLCHSVNEYQKPPFSYTHIIFMAIETSPNKAMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDG--------------------------RGGPGRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIFQXXXXXXXXXXXXXXXRSVVNNKLNS--SIDLQSSSRGPLLRIGGQLTDASNLIRS 1107
            DLQPL WLQ+++I+ I PLD E+E       PG DD+I    S  KV+V S+        +NS I D+ R+QAMR +M N ++                   +R NNS +    N  H  + + KP  SYT +IFMAIET  ++AMTVNDIY WCE ++PYY   G  WKNSLRHNLSINKSF+++ RDG                          +GGPGRGAYWVV+ +ER NL+D+I R+          + T P    N                             +++   S+ +     GP+LRI G+ TDAS  ++S
Sbjct:   71 DLQPLNWLQKESIIDIDPLDIEDELKDDSNTPGYDDLIDPHISHAKVEVESQ--------ENSNIHDFVRFQAMRNSMNNSNR-----------------VALRNNNSFTDCNQNYSHQASGFAKPNLSYTQLIFMAIETCKDRAMTVNDIYQWCEVNYPYYKHIGPSWKNSLRHNLSINKSFRRMPRDGQTTIGNYEMNSGDDMSEETISQRDNKQGGPGRGAYWVVDDKERKNLLDSIYRA----------HQTIPLSDRN---------------------------GQRIDPPYSLIVNPPKTGPMLRIDGRFTDASTYLQS 334

The following BLAST results are available for this feature:

BLAST of Fork head domain protein vs. Ensembl Human
BLAST of Fork head domain protein vs. Ensembl Celegans
BLAST of Fork head domain protein vs. Ensembl Fly
BLAST of Fork head domain protein vs. Ensembl Zebrafish
BLAST of Fork head domain protein vs. Ensembl Xenopus
BLAST of Fork head domain protein vs. Ensembl Mouse
BLAST of Fork head domain protein vs. UniProt/SwissProt
BLAST of Fork head domain protein vs. TrEMBL
BLAST of Fork head domain protein vs. Ensembl Cavefish
BLAST of Fork head domain protein vs. Ensembl Sea Lamprey
BLAST of Fork head domain protein vs. Ensembl Yeast
BLAST of Fork head domain protein vs. Ensembl Nematostella
BLAST of Fork head domain protein vs. Ensembl Medaka
BLAST of Fork head domain protein vs. Planmine SMEST

BLAST of Fork head domain protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
FOXN3	3.410e-29	51.06	forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928]	[more]
FOXN2	6.242e-28	49.49	forkhead box N2 [Source:HGNC Symbol;Acc:HGNC:5281]	[more]
FOXN2	1.240e-27	43.22	forkhead box N2 [Source:HGNC Symbol;Acc:HGNC:5281]	[more]
FOXN3	6.156e-27	48.15	forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928]	[more]
FOXN3	6.156e-27	48.15	forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928]	[more]

BLAST of Fork head domain protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
fkh-2	1.986e-19	42.16	ForKHead transcription factor family [Source:UniP...	[more]
fkh-6	1.422e-17	45.65	ForKHead transcription factor family [Source:UniP...	[more]
fkh-10	1.436e-17	46.25	ForKHead transcription factor family [Source:UniP...	[more]
fkh-10	1.436e-17	46.25	ForKHead transcription factor family [Source:UniP...	[more]
unc-130	4.869e-17	42.53	pep chromosome:WBcel235:II:11281986:11283953:1 gen...	[more]

BLAST of Fork head domain protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CHES-1-like	6.561e-26	52.38	gene:FBgn0029504 transcript:FBtr0112946	[more]
CHES-1-like	6.561e-26	52.38	gene:FBgn0029504 transcript:FBtr0333203	[more]
CHES-1-like	6.561e-26	52.38	gene:FBgn0029504 transcript:FBtr0071079	[more]
CHES-1-like	6.728e-26	52.38	gene:FBgn0029504 transcript:FBtr0310287	[more]
slp1	3.750e-19	45.45	gene:FBgn0003430 transcript:FBtr0077499	[more]

BLAST of Fork head domain protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
foxn3	7.205e-29	51.06	forkhead box N3 [Source:ZFIN;Acc:ZDB-GENE-060512-3...	[more]
foxn3	6.415e-28	51.06	forkhead box N3 [Source:ZFIN;Acc:ZDB-GENE-060512-3...	[more]
ches1	8.981e-28	49.00	checkpoint suppressor 1 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
ches1	9.791e-28	49.00	checkpoint suppressor 1 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
FOXN2	3.551e-27	47.22	forkhead box N2a [Source:NCBI gene;Acc:100330010]	[more]

BLAST of Fork head domain protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
foxn3	1.001e-27	52.13	forkhead box N3 [Source:NCBI gene;Acc:549054]	[more]
foxn3	1.082e-27	52.13	forkhead box N3 [Source:NCBI gene;Acc:549054]	[more]
adgrf3	3.251e-25	48.96	adhesion G protein-coupled receptor F3 [Source:Xen...	[more]
ndel1	3.609e-22	47.83	nudE neurodevelopment protein 1 like 1 [Source:Xen...	[more]
ndel1	3.634e-22	47.83	nudE neurodevelopment protein 1 like 1 [Source:Xen...	[more]

BLAST of Fork head domain protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Foxn3	6.184e-27	51.06	forkhead box N3 [Source:MGI Symbol;Acc:MGI:1918625...	[more]
Foxn3	6.184e-27	51.06	forkhead box N3 [Source:MGI Symbol;Acc:MGI:1918625...	[more]
Foxn3	6.184e-27	51.06	forkhead box N3 [Source:MGI Symbol;Acc:MGI:1918625...	[more]
Foxn2	4.199e-25	47.92	forkhead box N2 [Source:MGI Symbol;Acc:MGI:1347478...	[more]
Foxn3	1.753e-23	52.56	forkhead box N3 [Source:MGI Symbol;Acc:MGI:1918625...	[more]

BLAST of Fork head domain protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q28G71\|FOXN3_XENTR	5.734e-27	52.13	Forkhead box protein N3 OS=Xenopus tropicalis OX=8...	[more]
sp\|Q3BJS3\|FOXN3_XENLA	1.011e-26	51.06	Forkhead box protein N3 OS=Xenopus laevis OX=8355 ...	[more]
sp\|Q33BP8\|FOXN3_PIG	2.752e-26	51.06	Forkhead box protein N3 OS=Sus scrofa OX=9823 GN=F...	[more]
sp\|O00409\|FOXN3_HUMAN	3.680e-26	48.15	Forkhead box protein N3 OS=Homo sapiens OX=9606 GN...	[more]
sp\|Q499D0\|FOXN3_MOUSE	4.325e-26	51.06	Forkhead box protein N3 OS=Mus musculus OX=10090 G...	[more]

BLAST of Fork head domain protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0X3P2P9	5.463e-46	45.66	Forkhead box protein N3 (Fragment) OS=Schistocepha...	[more]
A0A5K3FM86	1.809e-44	46.82	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A2H1CVJ3	1.508e-42	41.98	Fork head domain protein OS=Fasciola hepatica OX=6...	[more]
A0A0X3PWA1	3.990e-42	45.66	Forkhead box protein N3 OS=Schistocephalus solidus...	[more]
G4VCD2	9.609e-42	34.77	Putative forkhead protein/ forkhead protein domain...	[more]

BLAST of Fork head domain protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ches1	4.707e-28	50.53	checkpoint suppressor 1 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
foxn3	5.581e-28	51.06	forkhead box N3 [Source:NCBI gene;Acc:103032353]	[more]
foxn3	5.581e-28	51.06	forkhead box N3 [Source:NCBI gene;Acc:103032353]	[more]
FOXN2	2.607e-26	51.09	forkhead box protein N2 [Source:NCBI gene;Acc:1030...	[more]
foxn2b	1.169e-25	50.00	forkhead box protein N2-like [Source:NCBI gene;Acc...	[more]

BLAST of Fork head domain protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
foxn3	2.008e-27	47.96	forkhead box N3 [Source:ZFIN;Acc:ZDB-GENE-060512-3...	[more]
foxf2a	2.084e-23	49.38	forkhead box F2a [Source:ZFIN;Acc:ZDB-GENE-110407-...	[more]
foxf2a	1.149e-22	49.38	forkhead box F2a [Source:ZFIN;Acc:ZDB-GENE-110407-...	[more]
foxj3	1.531e-22	45.10	forkhead box J3 [Source:ZFIN;Acc:ZDB-GENE-101005-1...	[more]
FOXC2	5.269e-21	46.43	forkhead box C2 [Source:HGNC Symbol;Acc:HGNC:3801]	[more]

BLAST of Fork head domain protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 4


Match Name	E-value	Identity	Description
HCM1	4.205e-16	43.21	Forkhead transcription factor; drives S-phase acti...	[more]
FKH2	7.677e-16	42.05	Forkhead family transcription factor; rate-limitin...	[more]
FKH1	7.999e-14	31.20	Forkhead family transcription factor; rate-limitin...	[more]
FHL1	6.036e-12	43.84	Regulator of ribosomal protein (RP) transcription;...	[more]

BLAST of Fork head domain protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO49084	4.232e-32	54.26	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39529	1.178e-21	45.83	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36306	2.223e-21	53.16	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47812	2.776e-21	50.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35022	1.608e-20	40.00	Forkhead domain protein 1; Predicted protein [Sou...	[more]

BLAST of Fork head domain protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ches1	1.239e-28	36.96	forkhead box N3 [Source:NCBI gene;Acc:101159152]	[more]
FOXN2	3.710e-26	51.09	forkhead box N2 [Source:NCBI gene;Acc:101160261]	[more]
FOXN2	4.070e-26	51.09	forkhead box N2 [Source:NCBI gene;Acc:101160261]	[more]
ENSORLT00000031716.1	4.038e-24	36.88	forkhead box protein J3 [Source:NCBI gene;Acc:1011...	[more]
si:ch211-145o7.3	1.426e-23	46.67	forkhead box protein N2 [Source:NCBI gene;Acc:1011...	[more]

BLAST of Fork head domain protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000048193.1	0.000e+0	99.78	SMESG000048193.1	[more]
SMESG000048193.1	0.000e+0	96.59	SMESG000048193.1	[more]
SMESG000033244.1	3.291e-54	39.87	SMESG000033244.1	[more]
SMESG000033244.1	7.686e-51	36.81	SMESG000033244.1	[more]
SMESG000033244.1	8.192e-51	36.81	SMESG000033244.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30009316 ID=SMED30009316|Name=Fork head domain protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3010bp
TATATAAATCTTATATGATAGAAATTGTAAATATTTAATTGTAGTATGAT
TGATTCTAACCAGTCTATTTATGATTTGCCATACCGTGCAAGAATTATGA
TGAATGCATGTATTGACAATCAAAAGTCTGGCTCAAATACAAAAATTAAT
CATATTAGCAATATTGAAAATCTTAAACCGATGAACTCAAAATCTGTGTT
AAAAACTAACAATAATTACACTTATTCTTCTGGAGATCTTCAACCTCTTC
AGTGGCTTCAGCAAGATACCATTCTTAGTATTACTCCTTTAGATAATGAA
GAAGAATATGTTCCTGGTAAAGATGACATAATATCTATAACAACTTCTCC
AGTGAAAGTCGATGTAATTTCTGAATTAAAATCAGAAGAATCATTGTACC
AAAATTCAACAATCGCAGATTATTATCGGTATCAAGCGATGCGAGCCGCA
ATGACCAACGGTCATCAAAATGGAGGCTACAGACAACAACACGGATATTT
ATCCTACTCAAACTCTTCAACCGGCGTTCGACCAAACAATTCAGGCAGCC
AGCATAATCTTTGTCATTCAGTCAATGAATATCAAAAGCCTCCGTTCAGT
TATACTCACATAATTTTCATGGCAATCGAGACAAGTCCCAATAAAGCCAT
GACAGTGAATGATATATACGTTTGGTGTGAAACGCATTTCCCATATTATA
CACAAGCTGGAGTTGGATGGAAAAATAGTCTGAGACACAATTTGTCGATT
AACAAATCATTCAAGAAAATCAGTCGAGATGGAAGGGGCGGACCTGGTCG
AGGTGCTTATTGGGTTGTTGAACCTCGGGAACGCAATAATTTGATTGATG
CAATTAGACGCAGCCCTTGCAGCCTTGGTAGTTTTCCATTTCTCAACAAT
ACATATCCATGGGGCACTGGAAATTGTTACTCAAACAACATTTTTCAATC
TGCAAATACTCTCAACAACAACTTAGCCTCGCTAACGGCGACACGTTCTG
TTGTTAACAATAAGCTCAATTCTTCTATCGATCTACAATCCTCATCACGT
GGGCCTTTATTGCGTATTGGTGGGCAACTTACTGATGCGTCTAATTTGAT
TCGATCAACTCCAGTTATTCAGAGGCTGAACGATTCCAGCAACATCATCG
AATTATCTAAAACTCCTCAAATCATATCCAATTCCATTACTTTATCTACA
GTTCCTTTAATTCAGTTTGATCAAATCAAATTTGAATCTGATATGACAAC
ATTCAATGAATCTATAGATTCTAATGATCTCTGTTCTGCTCAACAAGATG
AAGAAGACTGTCGTGGAAAGGTATTTATTATCGATGACTCGACCGAGTCG
AACCCAGAATTTTATCAGACATATCTGGACATTCTAAGAGGTCTGATTTA
TAATGACATTGAAAAATCGGATTCAATTAGATCAGAAAATACCAAAGATT
GCACAGAACACTTAAAAAATCGGAAACAATTTTTTTCTAAAAATAACTGT
AAATCAAGCGATGATATTCTACCAATAGAAGATATCGCTCCTATATCTAG
AAAAATAATCAAGAAACATTGCTCCTTAAAACAAAAAAGAAAATGCAAAT
GCGTAAAATCCGTTTCTGATTCTGGTGGGTCTGATTCATCACTATCAAAT
AAAGAATTCTCTGAATTGTCTGACACGGATTTCAATTCTCGTATAAGCAT
GGGTTTACGAAATCAAAAAAAAGAGAAAAAAAGGCTATATTTCAGTAAAT
TAAAGTCATTAACCAACAGTAGAAAATCATCGTATAATCGAAATCGTATT
AATAACATAGTCAGAGCACCACATTCAGATCATATTTACGCAATTCTGCA
GGAATTTCTCCCACCCGCCAATAAATCGGAAGAACACTCTCCAATTAATC
AAATGATTGATGACAAAGAATCCCTTTCTTCCACGATGGCCGATGATAAA
TCTCTATCCCTCGATTTGTCACAAACATCCTTATCAAAAAGATCCATGCA
CAAATTGCAGAGTCTTAAAAAATCAATGAAAAAGTTCAAATTTTCAGATT
CCGACGAAGAAATCTTTAATACTACTAATTATGAGAATATTTCTAACAAA
CTCATAAGAAATTCTTTGTCATTCATCACAAGAAAACGGAAATTAAACAA
GAACATGAATTCATCGAAAATTATTAAATATAATTCCCGATTGTTAAAGG
AAAATTCAGAATACATAAACAAAAAACCGTACCGGAAATATAACTACGAT
GACGATGAAGAACGTGAAAATCGTTGTTATGTTAAAAGCGAAATTACAGA
TGACACCTTTTCTAGTCCAATATATAAATCTTTGAAATTCGAGGATTTCA
ATAATGCATTTCAGGGAACTCTTGAAAATCTGAGCGATAATAAATCTAAT
AGCTACGATTCTCAGTTTATTCCTTTCAAAAAAATCCGACCTAACAAAGA
TACACACGTGAAACGGAAAGTTGGCAGACCAAAGAAATCTGAGTGCAATT
CGGTGACTTTTCGATACTCAAATGATCTTCGTAACAATAAACAGTCAAAT
ATTAAATCGAAAAAGAAAAACAAAACACCGAAACGAGATTTAAAATACCT
CAAAGAATGCAATTCAAACAAAAAAGTTGCCACAGAAATCAGCAATAAAG
ATGAGCAAGTGGCAATTAGCGTCTTAGCAAACTTACAGAAAAAGAACCAA
CAAGATCGGATCAAAAATATGTACAATTTATCGAATTATATCCAAAGAAA
CAGTTCAGATTCAAACATGAGTTAGCAATATTCCCCCATGAAGCCGGATT
CTCATGCATCGCCATAATTGCAATTGGAAAACTGCAAAATTACGAATTAT
TTTTTTTACCAGAAATTCTACAATTGTTTTTTATGACAGTTTGATAAATT
CATATCTGATTTTACTAGTTGCTAATAATAATGGTGCTCCTTCAGTCAAT
GCGTTTATTTATCATCTCTTCATCTCTGTATAAATTCCATCTTCTCTGTG
TCTATTGGTG

protein sequence of SMED30009316-orf-1

>SMED30009316-orf-1 ID=SMED30009316-orf-1|Name=SMED30009316-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=910bp
MIDSNQSIYDLPYRARIMMNACIDNQKSGSNTKINHISNIENLKPMNSKS
VLKTNNNYTYSSGDLQPLQWLQQDTILSITPLDNEEEYVPGKDDIISITT
SPVKVDVISELKSEESLYQNSTIADYYRYQAMRAAMTNGHQNGGYRQQHG
YLSYSNSSTGVRPNNSGSQHNLCHSVNEYQKPPFSYTHIIFMAIETSPNK
AMTVNDIYVWCETHFPYYTQAGVGWKNSLRHNLSINKSFKKISRDGRGGP
GRGAYWVVEPRERNNLIDAIRRSPCSLGSFPFLNNTYPWGTGNCYSNNIF
QSANTLNNNLASLTATRSVVNNKLNSSIDLQSSSRGPLLRIGGQLTDASN
LIRSTPVIQRLNDSSNIIELSKTPQIISNSITLSTVPLIQFDQIKFESDM
TTFNESIDSNDLCSAQQDEEDCRGKVFIIDDSTESNPEFYQTYLDILRGL
IYNDIEKSDSIRSENTKDCTEHLKNRKQFFSKNNCKSSDDILPIEDIAPI
SRKIIKKHCSLKQKRKCKCVKSVSDSGGSDSSLSNKEFSELSDTDFNSRI
SMGLRNQKKEKKRLYFSKLKSLTNSRKSSYNRNRINNIVRAPHSDHIYAI
LQEFLPPANKSEEHSPINQMIDDKESLSSTMADDKSLSLDLSQTSLSKRS
MHKLQSLKKSMKKFKFSDSDEEIFNTTNYENISNKLIRNSLSFITRKRKL
NKNMNSSKIIKYNSRLLKENSEYINKKPYRKYNYDDDEERENRCYVKSEI
TDDTFSSPIYKSLKFEDFNNAFQGTLENLSDNKSNSYDSQFIPFKKIRPN
KDTHVKRKVGRPKKSECNSVTFRYSNDLRNNKQSNIKSKKKNKTPKRDLK
YLKECNSNKKVATEISNKDEQVAISVLANLQKKNQQDRIKNMYNLSNYIQ
RNSSDSNMS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036388	WH-like_DNA-bd_sf
IPR036390	WH_DNA-bd_sf
IPR001766	Fork_head_dom
IPR011991	WHTH_DNA-bd_dom
IPR018122	TF_fork_head_CS_1
IPR030456	TF_fork_head_CS_2

Vocabulary: **molecular function**
Term	Definition
GO:0003700	transcription factor activity, sequence-specific DNA binding
GO:0043565	sequence-specific DNA binding
GO:0003677	DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated
GO:0006351	transcription, DNA-templated

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001766	Fork head domain	PRINTS	PR00053	FORKHEAD	coord: 225..242 score: 62.43 coord: 202..219 score: 37.74 coord: 181..194 score: 58.22
IPR001766	Fork head domain	SMART	SM00339	forkneu4	coord: 179..271 e-value: 8.0E-36 score: 135.0
IPR001766	Fork head domain	PFAM	PF00250	Forkhead	coord: 180..265 e-value: 3.9E-29 score: 100.7
IPR001766	Fork head domain	PROSITE	PS50039	FORK_HEAD_3	coord: 181..268 score: 28.668
IPR036388	Winged helix-like DNA-binding domain superfamily	GENE3D	G3DSA:1.10.10.10		coord: 168..273 e-value: 5.8E-32 score: 111.7
None	No IPR available	PANTHER	PTHR13962	FAMILY NOT NAMED	coord: 60..673
IPR018122	Fork head domain conserved site1	PROSITE	PS00657	FORK_HEAD_1	coord: 181..194
IPR030456	Fork head domain conserved site 2	PROSITE	PS00658	FORK_HEAD_2	coord: 225..231
IPR036390	Winged helix DNA-binding domain superfamily	SUPERFAMILY	SSF46785	"Winged helix" DNA-binding domain	coord: 180..272