TNF receptor associated factor-2

Overview
NameTNF receptor associated factor-2
Smed IDSMED30009201
Length (bp)1582
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TNF receptor associated factor-2 (SMED30009201) t-SNE clustered cells

Violin plots show distribution of expression levels for TNF receptor associated factor-2 (SMED30009201) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TNF receptor associated factor-2 (SMED30009201) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TNF receptor associated factor-2 (SMED30009201) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30009201

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30009201SMESG000024504.1 Contig1922GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30009201SMESG000024504.1 dd_Smed_v4_3038_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30009201SMESG000024504.1 dd_Smed_v4_3038_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30009201SMESG000024504.1 dd_Smed_v4_3038_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 80.4925 bits (197), Expect = 1.716e-15
Identity = 99/422 (23.46%), Postives = 181/422 (42.89%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPN--KLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEI----------FSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNEL----VENREQIQILR---QEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRN---------------EIDDTK-TKCELNTSI-ETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
              Y  K  ++  D+YKCE C  +LC+  Q ECG R+C  C A LL+S S  C    E      + ++ +  D+    E+L + + C N  + C+ +  L  +  HL+      + C F +  C     K   + + L+D +           SH K  + +I+      S L N  ++    ++++ N++    +E   Q ++LR    +++ L+    + +E +  L  +++   + N  E+DS++ S +S  +    LE++ K   +  RN                + D +    +L   + ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +  S    L      D   PNS+SF
Sbjct:   37 GGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQE-----SIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLK------NDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIA---LQVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIR-PFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD---PNSSSF 438
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 68.1662 bits (165), Expect = 1.780e-11
Identity = 106/480 (22.08%), Postives = 185/480 (38.54%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPN--KLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEI----------FSHSKILIEVISNIKND---------------------TSELWNMKIK--------------------YENDLKTIQNELVENREQIQILRQEV----IKLKSENSAL-----------------SESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRN--------------------EIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
              Y  K  ++  D+YKCE C  +LC+  Q ECG R+C  C A LL+S S  C    E      + ++ +  D+    E+L + + C N  + C+ +  L  +  HL+      + C F +  C     K   + + L+D +           SH K  + +I+  K++                      SE  N +IK                     E  +  +QNE VE  + IQ L  ++    I+++ +   L                 +E +  L  +++   + N  E+DS++ S +S  +    LE++ K   +  RN                     + D   + ++   +ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +  S    L      D   PNS+SF
Sbjct:   37 GGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQE-----SIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLK------NDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIR-PFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQV---LETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD---PNSSSF 496
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 68.1662 bits (165), Expect = 1.780e-11
Identity = 106/480 (22.08%), Postives = 185/480 (38.54%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPN--KLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEI----------FSHSKILIEVISNIKND---------------------TSELWNMKIK--------------------YENDLKTIQNELVENREQIQILRQEV----IKLKSENSAL-----------------SESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRN--------------------EIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
              Y  K  ++  D+YKCE C  +LC+  Q ECG R+C  C A LL+S S  C    E      + ++ +  D+    E+L + + C N  + C+ +  L  +  HL+      + C F +  C     K   + + L+D +           SH K  + +I+  K++                      SE  N +IK                     E  +  +QNE VE  + IQ L  ++    I+++ +   L                 +E +  L  +++   + N  E+DS++ S +S  +    LE++ K   +  RN                     + D   + ++   +ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +  S    L      D   PNS+SF
Sbjct:   37 GGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQE-----SIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLK------NDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIR-PFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQV---LETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD---PNSSSF 496
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Match: TRAF6 (TNF receptor associated factor 6 [Source:HGNC Symbol;Acc:HGNC:12036])

HSP 1 Score: 64.3142 bits (155), Expect = 2.458e-10
Identity = 35/116 (30.17%), Postives = 56/116 (48.28%), Query Frame = 1 
Query:  175 LNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            +  YD + +     +Y+C IC   L  A Q  CG R+C  C    +      CP ++E+     L EN +  D+    E+L ++VKCPN+ C  + EL+ ++ H   C   +  CP
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEI-----LLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Match: TRAF6 (TNF receptor associated factor 6 [Source:HGNC Symbol;Acc:HGNC:12036])

HSP 1 Score: 64.3142 bits (155), Expect = 2.458e-10
Identity = 35/116 (30.17%), Postives = 56/116 (48.28%), Query Frame = 1 
Query:  175 LNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            +  YD + +     +Y+C IC   L  A Q  CG R+C  C    +      CP ++E+     L EN +  D+    E+L ++VKCPN+ C  + EL+ ++ H   C   +  CP
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEI-----LLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Fly
Match: Traf6 (gene:FBgn0265464 transcript:FBtr0071188)

HSP 1 Score: 51.6026 bits (122), Expect = 1.206e-6
Identity = 34/145 (23.45%), Postives = 68/145 (46.90%), Query Frame = 1 
Query:  220 YKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNK--LCSFETELKDMDKHLRVCS------SKVDKCPFHQFGCGH-DKVKCSKMDEYLKDEIFSHSKILIEVI 627
            Y+C IC   L       CG R+C  C    +   ++ CP +++       AE++I  D+    E+ ++   CPN    CS      ++ +HL  C        + +KCPF +  C    + + ++++E+LK ++  H +++++  
Sbjct:  102 YECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMDNKRLS----AEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPYRRQQEPQEEKCPFAKIKCDFVGRPETNQLEEHLKADMPHHMQLMLQAF 242
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 64.3142 bits (155), Expect = 2.027e-10
Identity = 41/132 (31.06%), Postives = 63/132 (47.73%), Query Frame = 1 
Query:  184 YDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEY 579
            YD + +     +Y+C IC   L +A Q  CG R+C  C    +    + CP ++E+  + QL  +N         E+L + VKC N  CS + EL+ ++KHL  C      CP  Q     + V  S +DE+
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQLFPDNF-----AKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQ-----ESVPISHLDEH 178
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 64.3142 bits (155), Expect = 2.027e-10
Identity = 41/132 (31.06%), Postives = 63/132 (47.73%), Query Frame = 1 
Query:  184 YDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEY 579
            YD + +     +Y+C IC   L +A Q  CG R+C  C    +    + CP ++E+  + QL  +N         E+L + VKC N  CS + EL+ ++KHL  C      CP  Q     + V  S +DE+
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQLFPDNF-----AKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQ-----ESVPISHLDEH 178
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 64.3142 bits (155), Expect = 2.027e-10
Identity = 41/132 (31.06%), Postives = 63/132 (47.73%), Query Frame = 1 
Query:  184 YDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEY 579
            YD + +     +Y+C IC   L +A Q  CG R+C  C    +    + CP ++E+  + QL  +N         E+L + VKC N  CS + EL+ ++KHL  C      CP  Q     + V  S +DE+
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQLFPDNF-----AKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQ-----ESVPISHLDEH 178
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: traf3 (TNF receptor-associated factor 3 [Source:ZFIN;Acc:ZDB-GENE-040801-257])

HSP 1 Score: 55.0694 bits (131), Expect = 1.562e-7
Identity = 62/307 (20.20%), Postives = 135/307 (43.97%), Query Frame = 1 
Query:  427 VKCPNKLCSFETELK-DMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKIL------IEV-ISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVK--NKVQSNSSESDSIRLS-----------DKSFIDDKKLLENLLKIYYENPRNE----IDDTK-TKCELNTSI-ETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNN 1251
            V CPN  CSF + L+ ++  H   C      C F ++GC +  +   +M E+       H +++      +E  + ++K++  E + +     + L  ++ +  E RE+ + L Q+++ ++   S+ SE +  +  +++    +++   E +++R S           D S ++       L  +  +  R++    + D +  + +L   + ET+++     + W I     RK++   +K     S  FY     +K+    + NG     G   ++FF V+  + D+ L WPF  K+ + L + 
Sbjct:  204 VACPNH-CSFSSILRSELSSHQHDCPKAQVTCSFIRYGCSYKGLN-QEMREHESSFASEHLRMMAVRNTTLEAKVEDVKSELMERYKVLPSLSSRLAEVERQYEEMREKNRQLEQKLVSMQMLMSSHSEKLLEVEMELRELRPLRAMREEVETLRGSVESMRSMVSSLDSSCVNSASGSHTLASLEQQLTRHDDLMSVHDVRLAEMDLKLQVLETASFN--GTLIWKIRDYKRRKQEAVVSKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLQWPFKQKVTLMLMDQ 506

HSP 2 Score: 53.9138 bits (128), Expect = 3.656e-7
Identity = 34/109 (31.19%), Postives = 54/109 (49.54%), Query Frame = 1 
Query:  205 SNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNK--LCSFETELKDMDKHLRVCSSKVDKCPF 525
            +   +Y CE C+ +LCN  Q ECG R+C  C  +LL+  +  CP +      L L E+ I  D   N E++ + V C ++   C  +  L+ + +HL +C      CP 
Sbjct:   49 TPEPKYCCETCRLVLCNPRQTECGHRFCESCINELLSKPNPVCPADL-----LPLFEDKIFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVMEHLVICPYFEVPCPL 152
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: traf2b (Tnf receptor-associated factor 2b [Source:ZFIN;Acc:ZDB-GENE-030131-5345])

HSP 1 Score: 52.373 bits (124), Expect = 1.080e-6
Identity = 36/127 (28.35%), Postives = 54/127 (42.52%), Query Frame = 1 
Query:  205 SNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQI--------DHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKC 561
            S   +Y+C+ CK IL    Q +CG R+C  CF  L +S    C    E C+   + E    +        D+    E+  +  KCPN+ CS+   LKD +               H+  C  ++VKC
Sbjct:   51 SMEPKYQCQQCKDILRKPFQAQCGHRFCVFCFKQLTSSGPIPC----EACRAEGIFEEETSVLNIAVAFPDNAARREIDSLPAKCPNEGCSWSGTLKDFENQ-------------HEGRCAFERVKC 160
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 63.929 bits (154), Expect = 3.499e-10
Identity = 97/465 (20.86%), Postives = 178/465 (38.28%), Query Frame = 1 
Query:  184 YDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESK-----------------------------FCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHL-----------RVCSSKVD----------KCPFHQFGCGHD-KVKCSKMDEYLKDEIFSH---------------SKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLK-------IYYENPRNEIDDTKTKCELNTS--------IETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
            Y  +  +   ++YKCE C+ +LCN  Q ECG R+C  C   +L+S S                              FC   +  CK+L +   N+ I  + + +  ++   CP   C  +   KD+  H+           + C ++V            CP     C H   VK     E    +I +H               S  L   +S ++N++SE         N + + + E+  ++EQ++     +I+L+      ++ +  L  +++N ++    E+D ++ + +S  +    LE + K          E   N  D   +  ++  +        +ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +       L      D   PNS+SF
Sbjct:   34 YKERFLKPVEEKYKCEKCRLVLCNPRQTECGHRFCETCMNAILSSTSPQCMACEDNITKDKVFKDNCCRREVLALQMFCRNETRGCKEL-ITLGNLLIHLKSDCQFEEL--SCPRADCKEKVIRKDLSDHIEKTCKYRETPCKFCRNQVPLVEMQKHEDVDCPSVVISCPHMCSVKSLLRSEGTNQQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQLRNNEARIIQLQRVIEGQADKLKDLDKEIRN-LRQTGDEADGMKSNYESLQNRLSQLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRHLGDAFKPD---PNSSSF 489
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Xenopus
Match: egf (epidermal growth factor [Source:Xenbase;Acc:XB-GENE-951823])

HSP 1 Score: 60.4622 bits (145), Expect = 4.452e-9
Identity = 33/108 (30.56%), Postives = 53/108 (49.07%), Query Frame = 1 
Query:  175 LNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVC 498
            +  YD + +     +Y+C IC   L  A Q  CG R+C  C    +      CP ++E      L EN +  D+    E+L + VKCP++ C+   EL+ +++HL  C
Sbjct:   55 VQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACILKSIRDAGHKCPVDNE-----SLMENQLFPDNFAKREILSLRVKCPSQGCTETMELRHLERHLVRC 157
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 58.151 bits (139), Expect = 2.141e-8
Identity = 97/491 (19.76%), Postives = 179/491 (36.46%), Query Frame = 1 
Query:  184 YDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESK-----------------------------FCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPN---------------------------KLCSFETELKDMDKHLRV-CSSKVDKCP----------------------------FHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIE-------VISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLK-------IYYENPRNEIDDTKTKCELNTS--------IETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
            Y  +  +   ++YKCE C+ +LCN  Q ECG R+C  C   +L+S S                              FC   +  CK+L +   N+ I  + + +  ++   CP                            K C  +  L +M KH  V C S V  CP                            F ++GC        ++  +       H  ++ E        +S ++N++SE         N + + + E+  ++EQ++     +I+L+      ++ +  L  +++N ++    E+D ++ + +S  +    LE + K          E   N  D   +  ++  +        +ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +       L      D   PNS+SF
Sbjct:   34 YKERFLKPVEEKYKCEKCRLVLCNPRQTECGHRFCETCMNAILSSTSPQCMACEDNITKDKVFKDNCCRREVLALQMFCRNETRGCKEL-ITLGNLLIHLKSDCQFEEL--SCPRADCKEKVIRKDLSDHIEKTCKYRETPCKFCRNQVPLVEMQKHEDVDCPSVVISCPHMCSVKSLLRSELNAHLLECVNAPSTCSFKRYGCTFKGTN-QQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQLRNNEARIIQLQRVIEGQADKLKDLDKEIRN-LRQTGDEADGMKSNYESLQNRLSQLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRHLGDAFKPD---PNSSSF 514
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 71.633 bits (174), Expect = 1.066e-12
Identity = 108/480 (22.50%), Postives = 186/480 (38.75%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPN--KLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEI----------FSHSKILIEVISNIKND---------------------TSELWNMKIK--------------------YENDLKTIQNELVENREQIQILRQEV----IKLKSENSAL-----------------SESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRN--------------------EIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
              Y  K  ++  D+YKCE C+ +LCN  Q ECG R+C  C A LL+S S  C    E      + ++ +  D+    E+L + V C N  + C+ +  L  +  HL+      ++C F +  C     K   + + L+D +           SH K  + +I   K++                      SE  N +IK                     E  +  +QNE VE  + IQ L  ++    I+++ +   L                 +E +  L  +++   + N  E+DS++ S +S  +    LE++ K   +  RN                     + D   + ++   +ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +  S    L      D   PNS+SF
Sbjct:   36 GGYKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQE-----SIIKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLK------NECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIR-PFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQV---LETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD---PNSSSF 495
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 71.633 bits (174), Expect = 1.066e-12
Identity = 108/480 (22.50%), Postives = 186/480 (38.75%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPN--KLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEI----------FSHSKILIEVISNIKND---------------------TSELWNMKIK--------------------YENDLKTIQNELVENREQIQILRQEV----IKLKSENSAL-----------------SESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRN--------------------EIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
              Y  K  ++  D+YKCE C+ +LCN  Q ECG R+C  C A LL+S S  C    E      + ++ +  D+    E+L + V C N  + C+ +  L  +  HL+      ++C F +  C     K   + + L+D +           SH K  + +I   K++                      SE  N +IK                     E  +  +QNE VE  + IQ L  ++    I+++ +   L                 +E +  L  +++   + N  E+DS++ S +S  +    LE++ K   +  RN                     + D   + ++   +ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +  S    L      D   PNS+SF
Sbjct:   36 GGYKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQE-----SIIKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLK------NECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIR-PFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQV---LETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD---PNSSSF 495
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Match: Traf6 (TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072])

HSP 1 Score: 64.3142 bits (155), Expect = 1.802e-10
Identity = 36/116 (31.03%), Postives = 55/116 (47.41%), Query Frame = 1 
Query:  175 LNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            +  YD + +     +Y+C IC   L  A Q  CG R+C  C    +      CP ++E+     L EN +  D+    E+L + VKCPNK C  + EL+ ++ H   C   +  CP
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEI-----LLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 63.5438 bits (153), Expect = 3.270e-10
Identity = 80/372 (21.51%), Postives = 157/372 (42.20%), Query Frame = 1 
Query:  304 DLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELK-DMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNEL----VENREQIQILR---QEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRN--------------------EIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
            DL +   K C      C   +     I++    + +   +VV CP+K CS +T L+ ++  HL  C +    C F ++GC        ++  +       H  +L E  ++++   S L N  ++    ++++ N++    +E   Q ++LR    +++ L+    + +E +  L  +++   + N  E+DS++ S +S  +    LE++ K   +  RN                     + D   + ++   +ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +  S    L      D   PNS+SF
Sbjct:  160 DLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHK-CSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTN-QQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIR-PFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQV---LETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD---PNSSSF 520

HSP 2 Score: 56.9954 bits (136), Expect = 4.174e-8
Identity = 41/141 (29.08%), Postives = 67/141 (47.52%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPN--KLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEI 594
              Y  K  ++  D+YKCE C+ +LCN  Q ECG R+C  C A LL+S S  C    E      + ++ +  D+    E+L + V C N  + C+ +  L  +  HL+      ++C F +  C     K   + + L+D +
Sbjct:   36 GGYKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQE-----SIIKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLK------NECQFEELPCLRADCKEKVLRKDLRDHV 165
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 50.0618 bits (118), Expect = 2.032e-7
Identity = 24/52 (46.15%), Postives = 31/52 (59.62%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFC 333
              Y  K  ++  D+YKCE C+ +LCN  Q ECG R+C  C A LL+S S  C
Sbjct:   36 GGYKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKC 87
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|Q3ZCC3|TRAF6_BOVIN (TNF receptor-associated factor 6 OS=Bos taurus OX=9913 GN=TRAF6 PE=2 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 6.498e-10
Identity = 36/130 (27.69%), Postives = 62/130 (47.69%), Query Frame = 1 
Query:  133 VSNKVIMLQRMFKILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
             ++ V +     + +  YD + +     +Y+C IC   L  A Q  CG R+C  C    +      CP ++E+     L EN +  D+    E+L ++VKCPN+ C  + EL+ +++H   C   +  CP
Sbjct:   40 TASTVTLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEI-----LLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEEHQAHCEFALMSCP 164
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|B6CJY5|TRAF6_MACMU (TNF receptor-associated factor 6 OS=Macaca mulatta OX=9544 GN=TRAF6 PE=2 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 1.082e-9
Identity = 35/116 (30.17%), Postives = 56/116 (48.28%), Query Frame = 1 
Query:  175 LNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            +  YD + +     +Y+C IC   L  A Q  CG R+C  C    +      CP ++E+     L EN +  D+    E+L ++VKCPN+ C  + EL+ ++ H   C   +  CP
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEI-----LLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALVDCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|B6CJY4|TRAF6_CERAT (TNF receptor-associated factor 6 OS=Cercocebus atys OX=9531 GN=TRAF6 PE=2 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 1.091e-9
Identity = 35/116 (30.17%), Postives = 56/116 (48.28%), Query Frame = 1 
Query:  175 LNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            +  YD + +     +Y+C IC   L  A Q  CG R+C  C    +      CP ++E+     L EN +  D+    E+L ++VKCPN+ C  + EL+ ++ H   C   +  CP
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEI-----LLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALVDCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|Q9Y4K3|TRAF6_HUMAN (TNF receptor-associated factor 6 OS=Homo sapiens OX=9606 GN=TRAF6 PE=1 SV=1)

HSP 1 Score: 64.3142 bits (155), Expect = 1.180e-9
Identity = 35/116 (30.17%), Postives = 56/116 (48.28%), Query Frame = 1 
Query:  175 LNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            +  YD + +     +Y+C IC   L  A Q  CG R+C  C    +      CP ++E+     L EN +  D+    E+L ++VKCPN+ C  + EL+ ++ H   C   +  CP
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEI-----LLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|P70196|TRAF6_MOUSE (TNF receptor-associated factor 6 OS=Mus musculus OX=10090 GN=Traf6 PE=1 SV=2)

HSP 1 Score: 64.3142 bits (155), Expect = 1.261e-9
Identity = 36/116 (31.03%), Postives = 55/116 (47.41%), Query Frame = 1 
Query:  175 LNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            +  YD + +     +Y+C IC   L  A Q  CG R+C  C    +      CP ++E+     L EN +  D+    E+L + VKCPNK C  + EL+ ++ H   C   +  CP
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEI-----LLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: I1ZID8 (TNF receptor associated factor-2 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 151.754 bits (382), Expect = 3.432e-39
Identity = 71/200 (35.50%), Postives = 121/200 (60.50%), Query Frame = 1 
Query:  157 QRMFKILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAE-NNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEV 753
            +++ ++L  Y+F++E    D  KC++CK +L NACQ  CGCR+CSKC  + ++  + +CPG +  CK+  L   +NI  D+R+N ++ KM VKCP + C    EL D+++HLR+C+ K   CPF   GC   K+    +  +L++  F HSK++I++ISN++ND   L   +++   D+  I+N      E + ++  E+
Sbjct:    4 EKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMEYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLINSEI 203
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: T1E101 (TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 104.375 bits (259), Expect = 3.045e-20
Identity = 85/380 (22.37%), Postives = 187/380 (49.21%), Query Frame = 1 
Query:  154 LQRMFKILNKYDFK-IERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQL-AENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIK---NDTSELWNMKIKYENDLKTIQNEL-VENREQIQILRQEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYE-NPRNEIDDTKTKC-ELNTSIETSNY-------------KIIANIS----WDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPF 1218
            L  + ++L+KY+ K ++ S +++  C +C +++ +AC+  CGC YC  C    L+    +CPG+   CK+  L  E ++  + R++  + ++VVKCPN  C++ +EL  + +HL  C+ +  +CP    GC  + +   +M ++L D++  H+++++   + +K   N  +E     I +  ++  +Q  L  E   Q++ L +E+    +    LS+ +  +  ++   + S  SE   ++   + F  + + ++N L++    + +N++ D K +   +  +I+++N              K+  N+     W IE  S++++      S+ F ++  +  LNL  +        G+   ++  ++  +KD  L WP 
Sbjct:    6 LDNVQELLSKYNVKRVDESVNNDLLCILCNKLMRDACESACGCHYCYTCIRIYLSQNHNYCPGDKTECKEDYLNLEGDVFRNIRLSTRISRIVVKCPNIRCNYTSELLRLKEHLDKCTPESVECPCVTIGCEEEPLLKDEMAKHLTDQVLRHTQLIMSFCNELKSEINHNNETTKEDISHLKEVLRVQKALNDEKTAQMEFLIEELRNKDNMILVLSQDIQEVKNEMITLLTSKESELKKLKSDIQIFRQEIEFMKNDLEVVGSTDIKNQVKDLKKEIFGIKMNIDSNNEERERKMNNLIRLNKLCPNVDMDFMWRIEEYSKKRRTVTDVYSDSFQSHNYKFCLNLYIY--------GDNLGLWCVIMKGEKDDFLEWPM 377
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: A0A2K6N2X0 (TNF receptor-associated factor OS=Rhinopithecus bieti OX=61621 GN=TRAF3 PE=3 SV=1)

HSP 1 Score: 95.1301 bits (235), Expect = 4.250e-17
Identity = 99/415 (23.86%), Postives = 182/415 (43.86%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSE-LCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELK-DMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNEL----VENREQIQILR---QEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRN--------------------EIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
              Y  K  ++  D+YKCE C+ +LC+  Q ECG R+C  C A LL+S S  C    E + KD +  + +             +VV CP+K CS +  L+ ++  HL  C +    C F ++GC        ++  +       H  +L E  ++++   S L N  ++    ++++ N++    +E   Q ++LR    +++ L+    + +E +  L  +++   + N  E+DS++ S +S  +    LE++ K   +  RN                     + D   + ++   +ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +  S    L      D   PNS+SF
Sbjct:   37 GGYKEKFVKTVEDKYKCEKCRLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKKHEDTDCPC----------VVVSCPHK-CSVQALLRSELSAHLSECVNAPSTCSFKRYGCVFQGTN-QQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIR-PFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQV---LETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD---PNSSSF 430
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: A0A2U4CQ84 (TNF receptor-associated factor OS=Tursiops truncatus OX=9739 GN=TRAF3 PE=3 SV=1)

HSP 1 Score: 90.8929 bits (224), Expect = 1.269e-15
Identity = 103/416 (24.76%), Postives = 180/416 (43.27%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRM-NNELLKMVVKCPNKLCSFETELK-DMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNEL----VENREQIQILR------------QEVI-----KLKSENSALS------ESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNTSI-ETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
              Y  +  ++  D+YKCE C+ +LCN  Q ECG R+C  C   LL+S S  C      C++       I  D +  + E   +VV CP+K CS +T L+ ++  HL  C +    C F ++GC        ++  +       H  +L E  ++++   S L N  ++    ++++ N++    +E   Q ++LR            + VI     KLK  +  +       E    + + V++ +QS  +E +S+  S      +  LLE+ L   ++   +  D      +L   + ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +  S    L      D   PNS+SF
Sbjct:   41 GGYKERFVKAVEDKYKCEKCRLVLCNPKQTECGHRFCETCMGALLSSSSPKCTA----CRE------GISKDKKHEDTECPCVVVSCPHK-CSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTN-QQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQMWKRVIDSQAEKLKELDKEIRPFRQSWEEAGSMKSSVES-LQSRVTELESVDKSAGQAARNTGLLESQLS-RHDQMLSVHDIRLADMDLRFQVLETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD---PNSSSF 437
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: V8NPB7 (TNF receptor-associated factor 3 (Fragment) OS=Ophiophagus hannah OX=8665 GN=Traf3 PE=4 SV=1)

HSP 1 Score: 88.1965 bits (217), Expect = 1.128e-14
Identity = 104/456 (22.81%), Postives = 185/456 (40.57%), Query Frame = 1 
Query:  178 NKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESK-----------------------------FCPGNSELCKD-LQLAENNIQIDHRM-NNELLKMV-----------VKCPNKLCSFETEL-KDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNEL----VENREQIQILRQEVIKLKSENSAL---SESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRN--------------------EIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSF 1320
              Y  K   +  D+YKCE C  ILCN  Q ECG RYC  C + LL+S S                              FC   ++ C+D L L +  +    ++ ++ + KM+           V CP++ CS    L K+++ HL  C +    C F ++GC        ++  +       H  +L E  + ++N  + L N  ++    ++T+ N++    +E   Q ++LR    K+      +   +E +  L  +++   + N  E+DS++ S +S  +    LE++ K   +  RN                     + D   + ++   +ET++Y  +  + W I     RK++    K     S  FY     +K+    + NG     G   ++FF ++  + D+ L WPF  K+ + L +       L      D   PNS+SF
Sbjct:   36 GGYKEKFVNAVEDKYKCEKCHLILCNPRQTECGHRYCETCMSSLLSSTSPKCTACQETIVKDKIFKDNCCRRELLALQIFCRNENKGCRDQLTLGQLLVNFGRKLYSSPMAKMLKHEDADCPCVMVTCPHQ-CSVSALLRKELNAHLSECINAPSTCSFKRYGCTFQGTN-QQVKAHEATSAVQHVDLLKEWSNCLENKVAMLQNESLEKNKSIQTLHNQICSFEIEIERQKEMLRSNETKIHHLQRVIDSQAEKLKELDKEIR-PFRQNWEEADSMKSSVESLQNRVTELESIDKNTGQGARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQV---LETASYNGV--LIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGPSRRHLGDAFKPD---PNSSSF 480
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 55.8398 bits (133), Expect = 6.256e-8
Identity = 32/113 (28.32%), Postives = 54/113 (47.79%), Query Frame = 1 
Query:  184 YDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            YD   +     +Y+C IC   L +A Q  CG R+C+ C    +    + CP ++E+     L E+ +  D+    E+L + V+C N  C  + EL+ ++ H+  C      CP
Sbjct:   56 YDVDFDPPLESKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNEV-----LTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELRHLENHIPHCKFATVPCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 55.8398 bits (133), Expect = 7.670e-8
Identity = 32/113 (28.32%), Postives = 54/113 (47.79%), Query Frame = 1 
Query:  184 YDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            YD   +     +Y+C IC   L +A Q  CG R+C+ C    +    + CP ++E+     L E+ +  D+    E+L + V+C N  C  + EL+ ++ H+  C      CP
Sbjct:   56 YDVDFDPPLESKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNEV-----LTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELRHLENHIPHCKFATVPCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 55.8398 bits (133), Expect = 7.670e-8
Identity = 32/113 (28.32%), Postives = 54/113 (47.79%), Query Frame = 1 
Query:  184 YDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCP 522
            YD   +     +Y+C IC   L +A Q  CG R+C+ C    +    + CP ++E+     L E+ +  D+    E+L + V+C N  C  + EL+ ++ H+  C      CP
Sbjct:   56 YDVDFDPPLESKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNEV-----LTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELRHLENHIPHCKFATVPCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf5 (TNF receptor-associated factor 5 [Source:NCBI gene;Acc:103031120])

HSP 1 Score: 51.6026 bits (122), Expect = 1.444e-6
Identity = 66/336 (19.64%), Postives = 133/336 (39.58%), Query Frame = 1 
Query:  304 DLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSY---LTTKVKNKVQS--NSSESDSIRLSDKSFIDDKKLLENLLK--IYYENPRNEIDDTKTKCELNT------------------SIETSNYKIIANISWDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKI 1236
            +L + +   C   +ELC+  Q      Q+         +  V+CPNK C    +   +  H   C  +   C + ++GC   + K  ++  + + E   H  +L+E  S +     +L       + D    Q EL E    +  L++EV K  +  SA+  SV     L + VK +++   +  E+D   L+ +  +  +  L++L +     ++ R  +      C+ +T                   +E+++Y     + W +     +K+      S  FY +   +KL+   +  G   + G   +++  ++    DS L WPF   + +
Sbjct:  154 NLPDHQRSHCSYRTELCRYCQKPYPVSQLTDHEKTSCPEAEVQCPNK-CIHLVKRHKLKDHADECPEQETDCIYKKYGCT-VRNKRGQVKVHEQTEFNHHVLLLLESNSKLIKQVDQL-------QQDFAAQQGELKERNLLVSNLKREVSKCDTTVSAMQRSVEEQRELVSSVKRELKDLRDVLEAD---LTKEELVSLRASLDSLREQVAMTQSLREHLGALGQTCQSHTRLLDIHVQQLQCSEQRFQQLESTSYD--GKLIWKVHDYHRKKEAGTALNSPPFYTSHSGYKLSARVYLGGEGTARGTHLSLYVMLMRGDFDSLLPWPFRQNVTL 475
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf1 (TNF receptor-associated factor 1-like [Source:NCBI gene;Acc:103045252])

HSP 1 Score: 49.6766 bits (117), Expect = 5.957e-6
Identity = 35/115 (30.43%), Postives = 54/115 (46.96%), Query Frame = 1 
Query:  220 YKCEICKRILCNACQGECGCRYCSKCFA-------DLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCG 543
            + C  C  +L  A Q +CG RYC  C         DL+ ++ K  PG SE    + L  ++   D+ +N E+ ++ V C N+ C + + LKD + H   C   +  C     GCG
Sbjct:   27 FLCSSCNNVLNEAHQTQCGHRYCRACVMWLLRNNKDLICTKCKEDPG-SESDSSMMLTLDHFFSDNAINKEIQELRVHCVNQGCGWRSTLKDFEDHQSQCEYALIPC---NIGCG 137
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002130.1 (pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 gene:ENSPMAG00000001936.1 transcript:ENSPMAT00000002130.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 64.3142 bits (155), Expect = 2.428e-11
Identity = 69/342 (20.18%), Postives = 132/342 (38.60%), Query Frame = 1 
Query:  310 LNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIK----LKSENSALSESVSYLTT--------KVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPR--------NEIDDTKTKCELNTS------IETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRL 1242
            L +    CP  +E CK    A     ++     E  +  + CPN          ++ +H+  C+     C FH  GC   +     + E+ +  + SH  ++I      +N   EL   +++   +  T  +E++  R  +  L Q++        S N+ L  ++  LT          V  +     +++ ++R    +  +  + LE  L     NP         +E   T     L+T+      +ET+ Y     + W I   + RK++    +     S  FY +   +K+    + NG     G   ++FF V+  + D+ L WPF  ++ + L
Sbjct:   22 LAAHRASCPHRAEFCKYCSAAVTCSLLERHHKEECAQYPLPCPNNCEEHGIPRAELSQHMSACAMSTKLCGFHMLGCTFKQGTSESVREHEESAVRSHFTLVIS-----RNSELELQCARLQCSIEDHTNMSEMLTQR--VAQLEQDLSHWSTLTGSNNTRLGSTLEMLTQHNEQLQSLHVAQRAPQRDADTAALRRDMATLRERLRALEAALG----NPGPCEERCHMHEQRLTMHDGLLDTAERRLQVLETAGYS--GKLVWKIRDYARRKQEAASGRTLSLYSQPFYTSPFGYKMCARAYLNGDGVGRGTHLSLFFVVMRGEYDALLEWPFRRRVTLSL 350
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Sea Lamprey
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 51.9878 bits (123), Expect = 2.221e-7
Identity = 30/103 (29.13%), Postives = 46/103 (44.66%), Query Frame = 1 
Query:  184 YDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCF--ADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKH 486
            Y+   E     +Y+C IC   L    Q  CG R+C  C   +  L      CP ++ +  + QL  +N         E+L + V+CPNK C    EL+ + +H
Sbjct:   51 YEADFEPPLESKYECPICLMALREPVQTPCGHRFCRACILHSMRLRDAGPKCPVDNAVLHEGQLFPDNF-----AKREILSLTVRCPNKPCGHRGELRALQEH 148
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Match: EDO41243 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4Z7])

HSP 1 Score: 59.6918 bits (143), Expect = 1.644e-9
Identity = 36/118 (30.51%), Postives = 61/118 (51.69%), Query Frame = 1 
Query:  169 KILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKF-CPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKC 519
             + + YD +   + ++EY C IC   L    Q +CG R+C +C  +    +S+  CP + E    L L + ++ +D      +L  +VKCP K C +E EL+D++ H R C  ++  C
Sbjct:    6 PVPSGYDSEFVIAVAEEYTCRICHLPLRVPVQTKCGHRFCKECLDEASRRKSRAECPMDRE---PLDL-KKDVFLDKAAERTILSFLVKCPCKGCKWEAELRDLEAHARNCDYELVTC 119
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Match: EDO27426 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T9A1])

HSP 1 Score: 54.6842 bits (130), Expect = 8.590e-9
Identity = 33/111 (29.73%), Postives = 58/111 (52.25%), Query Frame = 1 
Query:  172 ILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKF-CPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCS 501
            + + YD +   + ++EY C IC   L    Q +CG R+C +C  +    +S+  CP + E    L L + ++ +D      +L  +VKCP K C +E EL+D++  ++ C 
Sbjct:    7 VPSGYDSEFVIAVAEEYTCRICHLPLRVPVQTKCGHRFCKECLDEASRRKSRAECPMDRE---PLDL-KKDVFLDKAAERTILSFLVKCPCKGCKWEAELRDLEVSMKGCG 113
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Match: EDO31692 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX78])

HSP 1 Score: 56.6102 bits (135), Expect = 1.080e-8
Identity = 37/112 (33.04%), Postives = 52/112 (46.43%), Query Frame = 1 
Query:  193 KIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKF-CPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPF 525
            + E   S E  C IC  ++       CG  YC+ CF    N +    CP + +     QL  N    D +   ++L + VKC N  CS++ EL+D  KHL  C  +V KC F
Sbjct:   16 QFETPPSPELMCGICLMVVNKPVLTYCGHSYCNFCFNKWRNGKDVVTCPVDYK-----QLETNQFMADKKTERQVLSLCVKCMNGPCSWKGELRDKKKHLTKCDHEVIKCVF 122
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Match: EDO31690 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX76])

HSP 1 Score: 55.8398 bits (133), Expect = 1.818e-8
Identity = 36/112 (32.14%), Postives = 52/112 (46.43%), Query Frame = 1 
Query:  193 KIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKF-CPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPF 525
            + E   S E  C IC  ++       CG  +C+ CF    N +    CP + +     QL  N    D +   ++L + VKC N  CS++ EL+D  KHL  C  +V KC F
Sbjct:   16 QFETPPSPELMCGICLMVVNKPVLTYCGHSFCNFCFNKWRNGKDVVTCPVDYK-----QLETNQFMADKKTERQVLSLCVKCMNGPCSWKGELRDKKKHLTKCGHEVIKCVF 122
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Match: EDO48394 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJK8])

HSP 1 Score: 55.4546 bits (132), Expect = 2.944e-8
Identity = 35/103 (33.98%), Postives = 49/103 (47.57%), Query Frame = 1 
Query:  214 DEYKCEICKRILCNACQGECGCRYCSKCFADLLNS-ESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKC 519
            DE  C IC  ++       CG  YC  C     N  E   CP ++E     QL  + I  D + +  +L + VKC N  C ++ EL+   KHL++CS K  KC
Sbjct:   26 DELICAICHMVVNEPVLTSCGHSYCKYCIEKWCNGKEVVTCPVDNE-----QLKPSQIFPDKKTDRIVLSLEVKCTNNPCRWKGELRQKQKHLKICSHKAVKC 123
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Medaka
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:101161132])

HSP 1 Score: 67.781 bits (164), Expect = 1.435e-11
Identity = 36/115 (31.30%), Postives = 57/115 (49.57%), Query Frame = 1 
Query:  175 LNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKC 519
            L  YD + +     +Y+C IC   L NA Q  CG R+C  C    +    + CP ++E+     L+E+ +  D+    E+L + V+CPN  C  + EL+ ++KHL  C      C
Sbjct:   61 LQGYDVEFDPPLESKYECPICLMALRNAIQTRCGHRFCKSCIEKSIRDTGQRCPVDNEM-----LSEDQLFPDNFAKREILSLTVRCPNSDCGEKMELRHLEKHLAQCQFATVPC 170
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Medaka
Match: traf3 (TNF receptor associated factor 3 [Source:NCBI gene;Acc:101161601])

HSP 1 Score: 56.225 bits (134), Expect = 4.478e-8
Identity = 75/352 (21.31%), Postives = 135/352 (38.35%), Query Frame = 1 
Query:  217 EYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKL--CSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVK---------NKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNTS--------IETSNYKIIANISWDIERLSERKKKNNWAK-----SNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDS 1200
            +Y CE C+ +LC   Q ECG R+C  C  D+L+  +  CP + E      L ++ I  D   + E++ + V C ++   C  +  L+ +  H+ V       CPF +  C   K K    +  ++ EI  H    +      +  T E    K+           EL +++E +             +S+L  S   +++  +           ++    E +S+R +  +       LE   +   E   N  DD  +  E+  +        +ET++Y     + W I     RK+     K     S  FY     +K+    + NG     G   ++FF V+  + D+
Sbjct:   45 KYCCEACRLVLCQPRQTECGHRFCYSCINDILSCPNPVCPADME-----PLFKDKIFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIPDHVNV-------CPFFEVPCPLGKCK----ERMMRKEIPEH----LAWKCKYRESTCEFCKNKMPL--------TELQKHKETVCPAFPVSCPNHCTSSSLPRSEKLMSSHTEKLLELELELRSLRQLRDEMESLRGTLDTVRTRLSALEQGGRASLETQLNRHDDMLSVHEIRLADMDLRFQVLETASYN--GTLIWKIRDYKRRKQDAVAGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDA 366
[Close]
BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024504.1 (SMESG000024504.1)

HSP 1 Score: 926.391 bits (2393), Expect = 0.000e+0
Identity = 467/467 (100.00%), Postives = 467/467 (100.00%), Query Frame = 1 
Query:   19 MLSNGNMTVHINRWSKVQKSIINSQNGSINHYCKTMNIVSNKVIMLQRMFKILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSFICSDPFDFSYNELFTLGLLRHDCLRIECFVYDE 1419
            MLSNGNMTVHINRWSKVQKSIINSQNGSINHYCKTMNIVSNKVIMLQRMFKILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYSLESSLELEKLCDLKMPNSNSFICSDPFDFSYNELFTLGLLRHDCLRIECFVYDE
Sbjct:    1 MLSNGNMTVHINRWSKVQKSIINSQNGSINHYCKTMNIVSNKVIMLQRMFKILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYSLESSLELEKLCDLKMPNSNSFICSDPFDFSYNELFTLGLLRHDCLRIECFVYDE 467
[Close]
BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024584.1 (SMESG000024584.1)

HSP 1 Score: 213.001 bits (541), Expect = 3.320e-63
Identity = 131/424 (30.90%), Postives = 224/424 (52.83%), Query Frame = 1 
Query:  157 QRMFKILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAE-NNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNT-SIETSNYKII----ANISWDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSNSFICSDPFDFSYNELFTLGLLRHDCLRIECFV 1410
            +++ ++L  Y+F++E    D  KC++CK +L NACQ  CGCR+CSKC  + ++  + +CPG +  CK+  L   +NI  D+R+N ++ KM VKCP + C    EL D+++HLR+C+ K   CPF   GC   K+    +  +L++  F HSK++I++ISN++ND   L   +++   D+  I+N      E + ++  E+  +K EN         L  +V++K+       + I+L++      K+    ++       R +  + + + EL   +IE+   + I       SW++  +S ++K+N    S +FY    +HK++L F AN           +F  + S  ++S L WPF   + I++ N    +SS  + K   ++ P  N +  SDPF F Y+EL   GLL +D   IECFV
Sbjct:    4 EKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMEYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLINSEIEIIKKENIECINEFKNLKIEVEDKM---VDLVEKIKLAETK---TKQECAEIVTAEVSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCN-YNWSDPFYFCYDELSGAGLLLNDSFTIECFV 420
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BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024592.1 (SMESG000024592.1)

HSP 1 Score: 203.371 bits (516), Expect = 1.416e-59
Identity = 130/437 (29.75%), Postives = 225/437 (51.49%), Query Frame = 1 
Query:  154 LQRMFKILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLS-DKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLC--------------DLKMPNSN---SFICSDPFDFSYNELFTLGLLRHDCLRIECFV 1410
            L  +F+++ K DF+   + S++ KC +C++IL NA Q  CGC +C KC  + + +E K CPG SE CK   L   N+QID++ NN + K++VKCP K C ++ +L +MD HLR CS K  KCP++  GC    +   K+ ++++ EI+SH+ +++ + + +K     L + +  +E ++ +++N L E   QI+ L++E              V  LT K+  KV  N+   ++I L   K F  D+KL + +  +   N +   D      +     E     +  +I W IE++++ +KK    +S +FY   +++K+ L  +ANG     G+  +I+  +    K S + WPF   + I++ N     +S++  K C               L M +S     +   + FDF YNEL   G+L ++ + +EC V
Sbjct:    7 LDSIFELIMKNDFEAIENISEDLKCTLCEKILMNAYQSPCGCSFCQKCIEEFIQNEPKLCPGKSEECKQQFLT--NLQIDYKANNRVQKLIVKCPEKTCLYKCKLSNMDNHLRFCSKKSVKCPYYDLGCDEVAIATDKVIDHIQSEIYSHNSMILGINNQMKQSIEMLAHHEEIHEENITSLKNSLKEKENQIESLKRE--------------VEILTNKINEKVDQNALTLNAILLEMSKDF--DQKLKQAIYSVNESNEKYRKDILLRFNDPGKYDEEHFDSVAGSILWSIEKINKCRKKGGSVESEYFYLGYNKYKMKLLLYANGTGNVTGSGLSIYIYIYPCTKHSKVDWPFKGLVTIKVLNKLDTFASVKQSKYCIIDNFEEGLDDAEGSLFMDDSIDSCDYQWDNQFDFLYNELSASGVLDNNIITVECNV 425
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BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024592.1 (SMESG000024592.1)

HSP 1 Score: 198.364 bits (503), Expect = 5.487e-58
Identity = 126/414 (30.43%), Postives = 218/414 (52.66%), Query Frame = 1 
Query:  181 KYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSENSALSESVSYLTTKVKNKVQSNSSESDSIRLS-DKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMPNSN---SFICSDPFDFSYNELFTLGLLRHDCLRIECFV 1410
            K DF+   + S++ KC +C++IL NA Q  CGC +C KC  + + +E K CPG SE CK   L   N+QID++ NN + K++VKCP K C ++ +L +MD HLR CS K  KCP++  GC    +   K+ ++++ EI+SH+ +++ + + +K     L + +  +E ++ +++N L E   QI+ L++E              V  LT K+  KV  N+   ++I L   K F  D+KL + +  +   N +   D      +     E     +  +I W IE++++ +KK    +S +FY   +++K+ L  +ANG     G+  +I+  +    K S + WPF   + I++ N     +S++ +    L M +S     +   + FDF YNEL   G+L ++ + +EC V
Sbjct:    2 KNDFEAIENISEDLKCTLCEKILMNAYQSPCGCSFCQKCIEEFIQNEPKLCPGKSEECKQQFLT--NLQIDYKANNRVQKLIVKCPEKTCLYKCKLSNMDNHLRFCSKKSVKCPYYDLGCDEVAIATDKVIDHIQSEIYSHNSMILGINNQMKQSIEMLAHHEEIHEENITSLKNSLKEKENQIESLKRE--------------VEILTNKINEKVDQNALTLNAILLEMSKDF--DQKLKQAIYSVNESNEKYRKDILLRFNDPGKYDEEHFDSVAGSILWSIEKINKCRKKGGSVESEYFYLGYNKYKMKLLLYANGTGNVTGSGLSIYIYIYPCTKHSKVDWPFKGLVTIKVLNKLDTFASVKQKG--SLFMDDSIDSCDYQWDNQFDFLYNELSASGVLDNNIITVECNV 395
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BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024548.1 (SMESG000024548.1)

HSP 1 Score: 181.415 bits (459), Expect = 3.033e-51
Identity = 121/435 (27.82%), Postives = 218/435 (50.11%), Query Frame = 1 
Query:  133 VSNKVIMLQRMFKILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKSEN----SALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYXXXXXXXXXKLCDLKMP--NSNSFICSDPFDFSYNELFTLGLLRHDCLRIECFVYDE 1419
            ++N++  +    K+L  +  +I    S +  C +C++IL +ACQ  CGC +C  C  + L + ++ CPGN++ CK   L   +IQ D+++N  + K++VKC   LC ++ EL +++ HLR+C  K  KCP+   GC  +K+   +M ++L  E  +HSK++++ I ++KN+ S +      Y+ +++T++  L  N E I  +  E+  LK+ +    S   +S+      +K K++ N       R+  K    ++K L+ + +   E   ++I+  K    +   ++    K +    WD+  ++ ++ K  +  S  F+   + +++ L   ANG         T+      S  D  LTWPF  ++ I L N         + K+C L  P  NS SF  +D FDF YN+L +  +   D   +EC V DE
Sbjct:   13 LANRITEMNFAHKLLQLHQLEIYSDLSSDLICGMCEKILIDACQSRCGCSFCRNCVNEYLLTGNETCPGNTDECKTESLL--SIQTDYKVNKIISKLIVKCTETLCCYKCELINLEDHLRLCPKKSAKCPYFDIGCSVEKIVIEEMSDHLIKENCNHSKLMVDAIGSLKNEVSNIKRTSDTYKMEIETLRETLKRNEEFIYKISDEIQILKTNSFNKLSQFEDSIQ----SIKEKLERNELNLLIDRVQQKL---EEKFLQEVHQKIDEMKYDKIEMVKRISVVEKYMDEKLKKALGLFVWDVNDITSKRNKFGYLWSEHFFTKPNFYRMRLHLCANGSGAVKDVGLTLLLCSYPSVNDEFLTWPFSKEVTITLINKNDPLIKSCVTKMCFLNRPKENSYSFEWNDSFDFVYNDLISNNVFTDDGFIVECQVKDE 438
The following BLAST results are available for this feature:
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TRAF31.716e-1523.46TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF31.780e-1122.08TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF31.780e-1122.08TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF62.458e-1030.17TNF receptor associated factor 6 [Source:HGNC Symb... [more]
TRAF62.458e-1030.17TNF receptor associated factor 6 [Source:HGNC Symb... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor associated factor-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Traf61.206e-623.45gene:FBgn0265464 transcript:FBtr0071188[more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf62.027e-1031.06TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf62.027e-1031.06TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf62.027e-1031.06TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf31.562e-720.20TNF receptor-associated factor 3 [Source:ZFIN;Acc:... [more]
traf2b1.080e-628.35Tnf receptor-associated factor 2b [Source:ZFIN;Acc... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ssh23.499e-1020.86slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
egf4.452e-930.56epidermal growth factor [Source:Xenbase;Acc:XB-GEN... [more]
ssh22.141e-819.76slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Traf31.066e-1222.50TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf31.066e-1222.50TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf61.802e-1031.03TNF receptor-associated factor 6 [Source:MGI Symbo... [more]
Traf33.270e-1021.51TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf32.032e-746.15TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
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BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q3ZCC3|TRAF6_BOVIN6.498e-1027.69TNF receptor-associated factor 6 OS=Bos taurus OX=... [more]
sp|B6CJY5|TRAF6_MACMU1.082e-930.17TNF receptor-associated factor 6 OS=Macaca mulatta... [more]
sp|B6CJY4|TRAF6_CERAT1.091e-930.17TNF receptor-associated factor 6 OS=Cercocebus aty... [more]
sp|Q9Y4K3|TRAF6_HUMAN1.180e-930.17TNF receptor-associated factor 6 OS=Homo sapiens O... [more]
sp|P70196|TRAF6_MOUSE1.261e-931.03TNF receptor-associated factor 6 OS=Mus musculus O... [more]
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BLAST of TNF receptor associated factor-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I1ZID83.432e-3935.50TNF receptor associated factor-2 (Fragment) OS=Sch... [more]
T1E1013.045e-2022.37TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
A0A2K6N2X04.250e-1723.86TNF receptor-associated factor OS=Rhinopithecus bi... [more]
A0A2U4CQ841.269e-1524.76TNF receptor-associated factor OS=Tursiops truncat... [more]
V8NPB71.128e-1422.81TNF receptor-associated factor 3 (Fragment) OS=Oph... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf66.256e-828.32TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf67.670e-828.32TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf67.670e-828.32TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf51.444e-619.64TNF receptor-associated factor 5 [Source:NCBI gene... [more]
traf15.957e-630.43TNF receptor-associated factor 1-like [Source:NCBI... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSPMAT00000002130.12.428e-1120.18pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 g... [more]
traf62.221e-729.13TNF receptor-associated factor 6 [Source:NCBI gene... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO412431.644e-930.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO274268.590e-929.73Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO316921.080e-833.04Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO316901.818e-832.14Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO483942.944e-833.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
traf61.435e-1131.30TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf34.478e-821.31TNF receptor associated factor 3 [Source:NCBI gene... [more]
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BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000024504.10.000e+0100.00SMESG000024504.1[more]
SMESG000024584.13.320e-6330.90SMESG000024584.1[more]
SMESG000024592.11.416e-5929.75SMESG000024592.1[more]
SMESG000024592.15.487e-5830.43SMESG000024592.1[more]
SMESG000024548.13.033e-5127.82SMESG000024548.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30009201 ID=SMED30009201|Name=TNF receptor associated factor-2|organism=Schmidtea mediterranea sexual|type=transcript|length=1582bp
TCCGATCTTATCATATAAATGTTATCCAACGGAAACATGACTGTGCACAT
CAATCGATGGAGCAAAGTGCAAAAATCAATAATAAACTCACAAAATGGAT
CAATCAATCACTACTGCAAAACGATGAATATTGTGTCAAATAAAGTAATA
ATGCTACAAAGAATGTTCAAGATCCTCAACAAATATGACTTCAAAATTGA
ACGCAGCAATTCTGATGAGTATAAATGCGAAATTTGCAAACGTATCCTTT
GTAACGCTTGCCAAGGAGAGTGTGGATGTCGATACTGCAGCAAATGCTTC
GCAGATCTATTGAACAGCGAATCCAAATTTTGTCCTGGAAATTCCGAACT
ATGCAAGGATCTCCAACTGGCTGAAAACAACATTCAAATTGATCATAGAA
TGAACAACGAACTATTGAAAATGGTCGTCAAATGTCCAAATAAACTGTGT
AGCTTCGAAACGGAATTAAAGGACATGGATAAACATTTGCGAGTCTGTTC
ATCGAAGGTTGATAAATGCCCCTTTCATCAATTTGGATGTGGCCATGACA
AAGTGAAGTGCAGTAAGATGGACGAGTATTTGAAGGATGAAATTTTTTCC
CATAGTAAAATTTTAATCGAAGTCATTAGCAACATCAAAAACGACACCTC
AGAATTATGGAACATGAAAATAAAATACGAAAACGACTTAAAGACGATTC
AAAATGAACTAGTAGAAAATAGAGAACAAATTCAAATATTGCGCCAGGAA
GTAATTAAGTTAAAGAGCGAAAATAGCGCCTTGTCGGAAAGTGTAAGTTA
CCTAACGACGAAAGTTAAAAACAAAGTTCAATCCAATTCTTCAGAGTCAG
ATTCCATCCGACTTTCAGATAAGTCTTTTATTGATGATAAAAAATTACTG
GAAAACCTTTTAAAGATTTATTACGAAAATCCTCGCAATGAAATAGACGA
CACAAAAACCAAATGTGAACTCAACACATCAATAGAGACTTCAAATTACA
AAATTATTGCGAACATCTCATGGGACATTGAAAGACTTTCGGAAAGAAAG
AAAAAGAATAATTGGGCTAAAAGTAATTTCTTCTACGCCAATGGAGATCA
GCATAAACTAAATTTAACCTTCTGGGCCAATGGATATGAAAAGTCGGTCG
GAAATTGTGCAACCATATTTTTTAGAGTAATTTCAAGCCAGAAAGATTCA
AGTCTCACATGGCCATTTATAACAAAGATTAAGATTCGACTCACAAATAA
TTATTCCTTGGAATCCAGTCTAGAATTAGAAAAGTTATGTGACCTAAAAA
TGCCAAATTCCAATTCGTTTATTTGTTCTGACCCGTTCGACTTTTCTTAC
AATGAACTTTTCACTTTGGGACTTTTAAGGCATGACTGCTTAAGGATTGA
ATGTTTTGTTTATGATGAGTGATGAGGAACAAGAAAGGTCGGGTGGAGAA
ATTGCAAATCTTTAAATAATGGATTTTTGAAGTTCCTTTTTATTTCTCAA
AACCAGATTTCGTTTCTTTCCTCTGTATGAAATTCGGTTTCAATTTTTAC
GATTTTTAATAAAATAAATATTTCTGTCCAAC
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protein sequence of SMED30009201-orf-1

>SMED30009201-orf-1 ID=SMED30009201-orf-1|Name=SMED30009201-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=468bp
MLSNGNMTVHINRWSKVQKSIINSQNGSINHYCKTMNIVSNKVIMLQRMF
KILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNS
ESKFCPGNSELCKDLQLAENNIQIDHRMNNELLKMVVKCPNKLCSFETEL
KDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILI
EVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEVIKLKS
ENSALSESVSYLTTKVKNKVQSNSSESDSIRLSDKSFIDDKKLLENLLKI
YYENPRNEIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWA
KSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPF
ITKIKIRLTNNYSLESSLELEKLCDLKMPNSNSFICSDPFDFSYNELFTL
GLLRHDCLRIECFVYDE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR043211TNF_rcpt-assoc_TRAF
IPR008974TRAF-like
IPR013083Znf_RING/FYVE/PHD
IPR002083MATH/TRAF_dom
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0004842ubiquitin-protein transferase activity
GO:0008270zinc ion binding
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0006955immune response
GO:0007165signal transduction
GO:0016567protein ubiquitination
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 217..258
NoneNo IPR availablePANTHERPTHR10131:SF129TNF RECEPTOR-ASSOCIATED FACTOR 6coord: 52..163
NoneNo IPR availablePANTHERPTHR10131:SF129TNF RECEPTOR-ASSOCIATED FACTOR 6coord: 152..427
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 65..121
IPR008974TRAF-likeGENE3DG3DSA:2.60.210.10coord: 298..466
e-value: 1.1E-12
score: 49.7
IPR008974TRAF-likeSUPERFAMILYSSF49599TRAF domain-likecoord: 333..465
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 51..172
e-value: 6.6E-14
score: 53.9
IPR043211TNF receptor-associated factor TRAFPANTHERPTHR10131TNF RECEPTOR ASSOCIATED FACTORcoord: 52..163
coord: 152..427
IPR002083MATH/TRAF domainPROSITEPS50144MATHcoord: 330..467
score: 9.984