Histone-lysine N-methyltransferase SETMAR
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppSub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30009199 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Human
Match: SETMAR (SET domain and mariner transposase fusion gene [Source:HGNC Symbol;Acc:HGNC:10762]) HSP 1 Score: 62.3882 bits (150), Expect = 2.394e-10 Identity = 35/119 (29.41%), Postives = 66/119 (55.46%), Query Frame = 3 Query: 375 SLFLDSKWIILMGGLPPNETISVKYYCDLFKKLNIAVFEKLRRQIFDSNF-YL*HNNARPHMAIITQEKFKQPCLHIFEHPPYSPDLRPSNFYIFQPMKSALHGKDYSSFADVVHDIQQ 728 +++ + +I L P ETI+ + Y ++N + ++L+ + + L H+NARPH+A T +K + + HPPYSPDL P+N+++F+ + + L GK + + D + Q+ Sbjct: 395 TIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKL-QRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQE 512
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Human
Match: SETMAR (SET domain and mariner transposase fusion gene [Source:HGNC Symbol;Acc:HGNC:10762]) HSP 1 Score: 62.3882 bits (150), Expect = 2.867e-10 Identity = 35/119 (29.41%), Postives = 65/119 (54.62%), Query Frame = 3 Query: 375 SLFLDSKWIILMGGLPPNETISVKYYCDLFKKLNIAVFEKLRRQIFDSNF-YL*HNNARPHMAIITQEKFKQPCLHIFEHPPYSPDLRPSNFYIFQPMKSALHGKDYSSFADVVHDIQQ 728 +++ + +I L P ETI+ + Y ++N ++L+ + + L H+NARPH+A T +K + + HPPYSPDL P+N+++F+ + + L GK + + D + Q+ Sbjct: 534 TIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMN-QKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQE 651
BLAST of Histone-lysine N-methyltransferase SETMAR vs. UniProt/SwissProt
Match: sp|Q53H47|SETMR_HUMAN (Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens OX=9606 GN=SETMAR PE=1 SV=2) HSP 1 Score: 62.3882 bits (150), Expect = 1.377e-9 Identity = 35/119 (29.41%), Postives = 65/119 (54.62%), Query Frame = 3 Query: 375 SLFLDSKWIILMGGLPPNETISVKYYCDLFKKLNIAVFEKLRRQIFDSNF-YL*HNNARPHMAIITQEKFKQPCLHIFEHPPYSPDLRPSNFYIFQPMKSALHGKDYSSFADVVHDIQQ 728 +++ + +I L P ETI+ + Y ++N ++L+ + + L H+NARPH+A T +K + + HPPYSPDL P+N+++F+ + + L GK + + D + Q+ Sbjct: 534 TIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMN-QKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQE 651
BLAST of Histone-lysine N-methyltransferase SETMAR vs. TrEMBL
Match: A0A1B6F9Q7 (Uncharacterized protein (Fragment) OS=Cuerna arida OX=1464854 GN=g.37759 PE=4 SV=1) HSP 1 Score: 93.9745 bits (232), Expect = 2.150e-19 Identity = 48/127 (37.80%), Postives = 70/127 (55.12%), Query Frame = 3 Query: 369 IPSLFLDSKWIILMGGLPPNETISVKYYCDLFKKLNIAVFEKLRRQIFDSNFYL*HNNARPHMAIITQEKFKQPCLHIFEHPPYSPDLRPSNFYIFQPMKSALHGKDYSSFADVVHDIQQCSDLKPQ 749 + ++F D K ++L+ L T++ YYC L ++ A K R+Q + L H+NARPH A +TQEK +Q EHPPYSPDL P +F +F P+K AL G + S +V + +PQ Sbjct: 42 LATIFFDCKGVLLIDFLHERRTVNAAYYCQLLEQAKAAFRNKRRKQPI-RDVILLHDNARPHTAALTQEKLRQIHWETLEHPPYSPDLSPCDFRLFGPLKEALGGNRFESDEEVQEFVCNWFKTRPQ 167
BLAST of Histone-lysine N-methyltransferase SETMAR vs. TrEMBL
Match: A0A1B6HVW3 (Uncharacterized protein (Fragment) OS=Homalodisca liturata OX=320908 GN=g.15241 PE=4 SV=1) HSP 1 Score: 93.2041 bits (230), Expect = 2.164e-19 Identity = 48/127 (37.80%), Postives = 70/127 (55.12%), Query Frame = 3 Query: 369 IPSLFLDSKWIILMGGLPPNETISVKYYCDLFKKLNIAVFEKLRRQIFDSNFYL*HNNARPHMAIITQEKFKQPCLHIFEHPPYSPDLRPSNFYIFQPMKSALHGKDYSSFADVVHDIQQCSDLKPQ 749 + ++F D K ++L+ L T++ YYC L ++ A K R Q + L H+NARPH A +TQEK +Q EHPPYSPDL P +F++F P+K AL G + S +V + +PQ Sbjct: 25 LATIFFDCKGVLLIDFLHERRTVNAAYYCQLLEQAKAAFRNKRRNQPI-RDVILLHDNARPHTAALTQEKLRQIHWETLEHPPYSPDLSPCDFHLFGPLKEALGGNRFESDEEVQEFVCNWFKTQPQ 150
BLAST of Histone-lysine N-methyltransferase SETMAR vs. TrEMBL
Match: A0A1B6MQY6 (Uncharacterized protein (Fragment) OS=Graphocephala atropunctata OX=36148 GN=g.46574 PE=4 SV=1) HSP 1 Score: 94.3597 bits (233), Expect = 2.252e-19 Identity = 45/120 (37.50%), Postives = 71/120 (59.17%), Query Frame = 3 Query: 369 IPSLFLDSKWIILMGGLPPNETISVKYYCDLFKKLNIAVFEKLRRQIFDSNFYL*HNNARPHMAIITQEKFKQPCLHIFEHPPYSPDLRPSNFYIFQPMKSALHGKDYSSFADVVHDIQQ 728 + ++F D K ++L+ + P TI+ YCD ++L A+ K RR + S L H+NARPH A +TQ +Q +F+HPPYSPDL PS+F++F +K L G+ Y + ++ I + Sbjct: 55 MATVFWDQKGVLLVEFMEPGTTINAAVYCDTLRRLRRAIQNK-RRGLLTSGIVLLHDNARPHSAGLTQNLLRQFHWDVFDHPPYSPDLAPSDFHLFPELKKWLGGRRYDTHEELESSINE 173
BLAST of Histone-lysine N-methyltransferase SETMAR vs. TrEMBL
Match: A0A224XT40 (Putative transposase (Fragment) OS=Panstrongylus lignarius OX=156445 PE=4 SV=1) HSP 1 Score: 95.1301 bits (235), Expect = 1.145e-18 Identity = 44/126 (34.92%), Postives = 73/126 (57.94%), Query Frame = 3 Query: 369 IPSLFLDSKWIILMGGLPPNETISVKYYCDLFKKLNIAVFEKLRRQIFDSNFYL*HNNARPHMAIITQEKFKQPCLHIFEHPPYSPDLRPSNFYIFQPMKSALHGKDYSSFADVVHDIQQCSDLKP 746 + ++F D + ++ L TI+ YYCD+ ++ +A + + RR + L H+NARPH A +T+EK +Q +HPPYSPDL P +F++F P+K AL G+ + S A+V ++ +P Sbjct: 192 LATIFFDQRGLLHFDFLHERRTINAAYYCDILSEVRLA-YRRKRRDLSIRQVVLLHDNARPHTAALTREKLEQLGWETLQHPPYSPDLSPCDFHVFGPLKEALGGQRFDSDAEVEAYVRNWLQTRP 316
BLAST of Histone-lysine N-methyltransferase SETMAR vs. TrEMBL
Match: X1XP03 (Uncharacterized protein OS=Acyrthosiphon pisum OX=7029 PE=4 SV=1) HSP 1 Score: 90.5077 bits (223), Expect = 3.010e-18 Identity = 46/114 (40.35%), Postives = 67/114 (58.77%), Query Frame = 3 Query: 369 IPSLFLDSKWIILMGGLPPNETISVKYYCDLFKKLNIAVFEKLRRQIFDSNFYL*HNNARPHMAIITQEKFKQPCLHIFEHPPYSPDLRPSNFYIFQPMKSALHGKDYSSFADV 710 + S+F D K IIL+ LP ETI+ YC+ KKL A+ K RR + S L H+NARPH A +T++ + H PYSPDL PS++++F +K + GK +S+ +V Sbjct: 34 MASVFWDHKGIILIEYLPQGETINAARYCETLKKLRRAIQNK-RRGLLTSGVCLLHDNARPHTANVTKQLLDSFGWDVLNHTPYSPDLAPSDYHLFTSLKKHMGGKKFSADEEV 146
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Planmine SMEST
Match: SMESG000049199.1 (SMESG000049199.1) HSP 1 Score: 69.707 bits (169), Expect = 1.937e-14 Identity = 37/100 (37.00%), Postives = 55/100 (55.00%), Query Frame = 3 Query: 408 MGGLPPNETISVKYYCDLFKKLNIAVFEKLRRQIFDSNFYL*HN---NARPHMAIITQEKFKQPCLHIFEHPPYSPDLRPSNFYIFQPMKSALHGKDYSS 698 M LP TI+ Y + +L A+ K RR++ F+ H NARPH A + +K + HPPYSPDL S+FY+F P+KS++ G+D++ Sbjct: 1 MNILPQGTTITADVYYEQLSRLVTAIQHK-RRRLLGGGFHKIHYLQYNARPHTAAKSVQKLIDIGFTVLLHPPYSPDLATSDFYLFSPLKSSIRGRDFNG 99 The following BLAST results are available for this feature:
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 2
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 1
BLAST of Histone-lysine N-methyltransferase SETMAR vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Histone-lysine N-methyltransferase SETMAR vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30009199 ID=SMED30009199|Name=Histone-lysine N-methyltransferase SETMAR|organism=Schmidtea mediterranea sexual|type=transcript|length=889bpback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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