Non-specific serine/threonine protein kinase

Overview


Name	Non-specific serine/threonine protein kinase
Smed ID	SMED30009181
Length (bp)	2946

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Non-specific serine/threonine protein kinase (SMED30009181) t-SNE clustered cells

Violin plots show distribution of expression levels for Non-specific serine/threonine protein kinase (SMED30009181) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Non-specific serine/threonine protein kinase (SMED30009181) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30009181

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30009181	SMESG000057003.1	Contig2851	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30009181	SMESG000057003.1	Contig2851	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30009181	SMESG000014644.1	Contig2851	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30009181	SMESG000014644.1	Contig2851	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
protonephridia	SMED30009181	SMESG000057003.1 SMESG000037136.1	dd_Smed_v4_4425_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30009181	SMESG000057003.1 SMESG000037136.1	dd_Smed_v4_4425_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30009181	SMESG000057003.1 SMESG000037136.1	dd_Smed_v4_4425_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

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Homology

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 526.939 bits (1356), Expect = 1.370e-174
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMIRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 55.4546 bits (132), Expect = 5.285e-7
Identity = 31/107 (28.97%), Postives = 56/107 (52.34%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G  + + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  608 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHEKYMLLC---MHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 707

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 527.324 bits (1357), Expect = 1.678e-174
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMIRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 55.4546 bits (132), Expect = 5.243e-7
Identity = 31/107 (28.97%), Postives = 56/107 (52.34%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G  + + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  623 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHEKYMLLC---MHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 722

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 526.554 bits (1355), Expect = 2.400e-174
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMIRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 55.0694 bits (131), Expect = 6.253e-7
Identity = 31/107 (28.97%), Postives = 56/107 (52.34%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G  + + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  618 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHEKYMLLC---MHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 717

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 524.628 bits (1350), Expect = 5.230e-174
Identity = 237/331 (71.60%), Postives = 283/331 (85.50%), Query Frame = 1

Query:  130 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:    2 IRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 330

HSP 2 Score: 55.0694 bits (131), Expect = 5.887e-7
Identity = 31/107 (28.97%), Postives = 56/107 (52.34%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G  + + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  590 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHEKYMLLC---MHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 689

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: MARK2 (microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332])

HSP 1 Score: 527.709 bits (1358), Expect = 5.975e-174
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMIRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 55.4546 bits (132), Expect = 4.958e-7
Identity = 31/107 (28.97%), Postives = 56/107 (52.34%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G  + + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  677 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHEKYMLLC---MHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 776

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: par-1 (Serine/threonine-protein kinase par-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TW45])

HSP 1 Score: 496.893 bits (1278), Expect = 3.266e-160
Identity = 223/332 (67.17%), Postives = 279/332 (84.04%), Query Frame = 1

Query:  130 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMK---SLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            M++ +AA+ N  ++  H+GKYKL+KTIGKGNFAKVKLA+HV TG +VA+K+IDKTALN SSLQKLFREV+IMK +DHPNIVKL++V+E+E+ +YLV+EYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QY H K I+HRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELF G+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK L++NP +R +L ++MKD+W+N G+ED+ L+P+IEP K+  D  R+  +     LGF K  +L+S+   KF ++ ATYLLL
Sbjct:   88 MSSRSAARRN--DQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLL 417

[Close]

Query:  130 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMK---SLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            M++ +AA+ N  ++  H+GKYKL+KTIGKGNFAKVKLA+HV TG +VA+K+IDKTALN SSLQKLFREV+IMK +DHPNIVKL++V+E+E+ +YLV+EYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QY H K I+HRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELF G+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK L++NP +R +L ++MKD+W+N G+ED+ L+P+IEP K+  D  R+  +     LGF K  +L+S+   KF ++ ATYLLL
Sbjct:   88 MSSRSAARRN--DQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLL 417

[Close]

Query:  130 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMK---SLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            M++ +AA+ N  ++  H+GKYKL+KTIGKGNFAKVKLA+HV TG +VA+K+IDKTALN SSLQKLFREV+IMK +DHPNIVKL++V+E+E+ +YLV+EYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QY H K I+HRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELF G+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK L++NP +R +L ++MKD+W+N G+ED+ L+P+IEP K+  D  R+  +     LGF K  +L+S+   KF ++ ATYLLL
Sbjct:   88 MSSRSAARRN--DQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLL 417

[Close]

Query:  130 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMK---SLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            M++ +AA+ N  ++  H+GKYKL+KTIGKGNFAKVKLA+HV TG +VA+K+IDKTALN SSLQKLFREV+IMK +DHPNIVKL++V+E+E+ +YLV+EYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QY H K I+HRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELF G+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK L++NP +R +L ++MKD+W+N G+ED+ L+P+IEP K+  D  R+  +     LGF K  +L+S+   KF ++ ATYLLL
Sbjct:   88 MSSRSAARRN--DQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLL 417

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Query:  130 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMK---SLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            M++ +AA+ N  ++  H+GKYKL+KTIGKGNFAKVKLA+HV TG +VA+K+IDKTALN SSLQKLFREV+IMK +DHPNIVKL++V+E+E+ +YLV+EYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QY H K I+HRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELF G+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK L++NP +R +L ++MKD+W+N G+ED+ L+P+IEP K+  D  R+  +     LGF K  +L+S+   KF ++ ATYLLL
Sbjct:   88 MSSRSAARRN--DQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLL 417

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0301505)

HSP 1 Score: 513.842 bits (1322), Expect = 2.320e-168
Identity = 224/320 (70.00%), Postives = 274/320 (85.62%), Query Frame = 1

Query:  160 KWNE-QPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            +W   + HIGKYKLIKTIGKGNFAKVKLA+H+ TGK+VA+K+IDKT LN  SLQKLFREVRIMK +DHPNIVKLF+VIE+E+ +YL+MEYAS GEVFDYLV +GRMKEK+AR++FR+IVSA+QYCH K+I+HRDLKAENLLL ++L IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG  +RELRERVLRGKYRIPFYM+TDCE LL+K L++NP KR +L  +M DKW+N GFE++ L+PYIEPK +  DP R+  + ++G+ + E+  SL   ++++V ATYLLL
Sbjct:  242 RWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLL 561

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0330243)

HSP 1 Score: 513.457 bits (1321), Expect = 4.071e-168
Identity = 224/320 (70.00%), Postives = 274/320 (85.62%), Query Frame = 1

Query:  160 KWNE-QPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            +W   + HIGKYKLIKTIGKGNFAKVKLA+H+ TGK+VA+K+IDKT LN  SLQKLFREVRIMK +DHPNIVKLF+VIE+E+ +YL+MEYAS GEVFDYLV +GRMKEK+AR++FR+IVSA+QYCH K+I+HRDLKAENLLL ++L IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG  +RELRERVLRGKYRIPFYM+TDCE LL+K L++NP KR +L  +M DKW+N GFE++ L+PYIEPK +  DP R+  + ++G+ + E+  SL   ++++V ATYLLL
Sbjct:  242 RWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLL 561

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0100390)

HSP 1 Score: 513.072 bits (1320), Expect = 6.491e-168
Identity = 224/320 (70.00%), Postives = 274/320 (85.62%), Query Frame = 1

Query:  160 KWNE-QPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            +W   + HIGKYKLIKTIGKGNFAKVKLA+H+ TGK+VA+K+IDKT LN  SLQKLFREVRIMK +DHPNIVKLF+VIE+E+ +YL+MEYAS GEVFDYLV +GRMKEK+AR++FR+IVSA+QYCH K+I+HRDLKAENLLL ++L IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG  +RELRERVLRGKYRIPFYM+TDCE LL+K L++NP KR +L  +M DKW+N GFE++ L+PYIEPK +  DP R+  + ++G+ + E+  SL   ++++V ATYLLL
Sbjct:  242 RWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLL 561

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0086450)

HSP 1 Score: 511.146 bits (1315), Expect = 6.460e-166
Identity = 224/320 (70.00%), Postives = 274/320 (85.62%), Query Frame = 1

Query:  160 KWNE-QPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            +W   + HIGKYKLIKTIGKGNFAKVKLA+H+ TGK+VA+K+IDKT LN  SLQKLFREVRIMK +DHPNIVKLF+VIE+E+ +YL+MEYAS GEVFDYLV +GRMKEK+AR++FR+IVSA+QYCH K+I+HRDLKAENLLL ++L IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG  +RELRERVLRGKYRIPFYM+TDCE LL+K L++NP KR +L  +M DKW+N GFE++ L+PYIEPK +  DP R+  + ++G+ + E+  SL   ++++V ATYLLL
Sbjct:  242 RWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLL 561

HSP 2 Score: 61.2326 bits (147), Expect = 4.653e-9
Identity = 36/104 (34.62%), Postives = 57/104 (54.81%), Query Frame = 1

Query: 2503 TLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAI 2814
            T+     KPRV+   +    TS L P+ I+ ++ + L + +  D+   EQ + FV+ C   +  +   + L+ WEIEV +LPR S  G+R K+ SG+S  FK I
Sbjct:  832 TIADEAAKPRVLRFTWSMKTTSPLMPDQIMQKIREVL-DQNNCDY---EQRERFVLWC---VHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNI 928

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: par-1 (gene:FBgn0260934 transcript:FBtr0301504)

HSP 1 Score: 513.457 bits (1321), Expect = 1.465e-165
Identity = 232/346 (67.05%), Postives = 287/346 (82.95%), Query Frame = 1

Query:  160 KWNE-QPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNN 1194
            +W   + HIGKYKLIKTIGKGNFAKVKLA+H+ TGK+VA+K+IDKT LN  SLQKLFREVRIMK +DHPNIVKLF+VIE+E+ +YL+MEYAS GEVFDYLV +GRMKEK+AR++FR+IVSA+QYCH K+I+HRDLKAENLLL ++L IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG  +RELRERVLRGKYRIPFYM+TDCE LL+K L++NP KR +L  +M DKW+N GFE++ L+PYIEPK +  DP R+  + ++G+ + E+  SL   ++++V ATYLLL     +   + S+S S  SL+N+S N
Sbjct:  470 RWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGN 815

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark2a (MAP/microtubule affinity-regulating kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-4145])

HSP 1 Score: 531.561 bits (1368), Expect = 6.201e-176
Identity = 248/368 (67.39%), Postives = 300/368 (81.52%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDH--TKHATSKAANDASVTRS 1263
            +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK L++NP KR +L  +MKD+W+N G ED  L+PYIEP+ +Y+DP R  IM  +G++ DE+ DSL N K+N+V ATYLLLD+  +   E S K+  G  + N + + S K    T +  S+ + D S   S
Sbjct:   36 DEQPHIGCYRLLKTIGKGNFAKVKLAKHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVLNPTKRGSLEQIMKDRWMNVGHEDEELKPYIEPQPDYKDPKRTDIMIRMGYSLDEIQDSLINQKYNDVMATYLLLDYRNSELDELSIKARPGTDITNNAQSPSHKGQRSTSNLKSRRSTDQSSVSS 403

HSP 2 Score: 55.8398 bits (133), Expect = 2.679e-7
Identity = 32/105 (30.48%), Postives = 55/105 (52.38%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P    +EMMK ++   + +  + E  + F++ C   +      ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  660 KPRSLRFTWSMKTTSSMEP----NEMMKEIRKVLDSNSCEYELRERFMLLC---MSGNPAHDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 757

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark2a (MAP/microtubule affinity-regulating kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-4145])

HSP 1 Score: 531.176 bits (1367), Expect = 8.771e-176
Identity = 248/368 (67.39%), Postives = 300/368 (81.52%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDH--TKHATSKAANDASVTRS 1263
            +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK L++NP KR +L  +MKD+W+N G ED  L+PYIEP+ +Y+DP R  IM  +G++ DE+ DSL N K+N+V ATYLLLD+  +   E S K+  G  + N + + S K    T +  S+ + D S   S
Sbjct:   36 DEQPHIGCYRLLKTIGKGNFAKVKLAKHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVLNPTKRGSLEQIMKDRWMNVGHEDEELKPYIEPQPDYKDPKRTDIMIRMGYSLDEIQDSLINQKYNDVMATYLLLDYRNSELDELSIKARPGTDITNNAQSPSHKGQRSTSNLKSRRSTDQSSVSS 403

HSP 2 Score: 55.4546 bits (132), Expect = 2.938e-7
Identity = 32/105 (30.48%), Postives = 55/105 (52.38%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P    +EMMK ++   + +  + E  + F++ C   +      ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  657 KPRSLRFTWSMKTTSSMEP----NEMMKEIRKVLDSNSCEYELRERFMLLC---MSGNPAHDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 754

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark2b (MAP/microtubule affinity-regulating kinase 2b [Source:ZFIN;Acc:ZDB-GENE-080215-4])

HSP 1 Score: 528.094 bits (1359), Expect = 1.591e-174
Identity = 240/341 (70.38%), Postives = 289/341 (84.75%), Query Frame = 1

Query:  169 EQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH---DVNNTLENSSKSDSGNSLKN 1182
            E PHIG Y+L+KTIGKGNFAKVKLA+HV T K+VAVK+IDKT LN+SSLQK+FREVRIMK ++HPNIVKLFEVIE+++ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F V  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  +MKD+W+N G+ED+ L+PYIEP+ +Y+DP R  IM  +GF+++E+ DSL   K+N V ATYLLLD+   +++  +  S KS  G+ L N
Sbjct:   42 EYPHIGNYRLLKTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLNSSSLQKVFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQIMKDRWMNVGYEDDDLKPYIEPQPDYKDPRRTDIMLQMGFSQEEIEDSLVKQKYNEVMATYLLLDYRNSELDEGVNLSLKSRPGSDLTN 382

HSP 2 Score: 59.6918 bits (143), Expect = 1.493e-8
Identity = 33/108 (30.56%), Postives = 58/108 (53.70%), Query Frame = 1

Query: 2515 NQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            +Q+KPR +   +    TS + P    SEMMK ++   + +  + E  + +++ C   +      ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  665 DQSKPRSLRFTWSMKTTSSMEP----SEMMKEIRKVLDANSCEYELRERYMLLC---MAGNPARDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 765

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark2b (MAP/microtubule affinity-regulating kinase 2b [Source:ZFIN;Acc:ZDB-GENE-080215-4])

HSP 1 Score: 528.094 bits (1359), Expect = 2.690e-174
Identity = 240/341 (70.38%), Postives = 289/341 (84.75%), Query Frame = 1

Query:  169 EQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH---DVNNTLENSSKSDSGNSLKN 1182
            E PHIG Y+L+KTIGKGNFAKVKLA+HV T K+VAVK+IDKT LN+SSLQK+FREVRIMK ++HPNIVKLFEVIE+++ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F V  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  +MKD+W+N G+ED+ L+PYIEP+ +Y+DP R  IM  +GF+++E+ DSL   K+N V ATYLLLD+   +++  +  S KS  G+ L N
Sbjct:   42 EYPHIGNYRLLKTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLNSSSLQKVFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQIMKDRWMNVGYEDDDLKPYIEPQPDYKDPRRTDIMLQMGFSQEEIEDSLVKQKYNEVMATYLLLDYRNSELDEGVNLSLKSRPGSDLTN 382

HSP 2 Score: 59.6918 bits (143), Expect = 1.652e-8
Identity = 33/108 (30.56%), Postives = 58/108 (53.70%), Query Frame = 1

Query: 2515 NQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            +Q+KPR +   +    TS + P    SEMMK ++   + +  + E  + +++ C   +      ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  678 DQSKPRSLRFTWSMKTTSSMEP----SEMMKEIRKVLDANSCEYELRERYMLLC---MAGNPARDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 778

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: mark2b (MAP/microtubule affinity-regulating kinase 2b [Source:ZFIN;Acc:ZDB-GENE-080215-4])

HSP 1 Score: 527.709 bits (1358), Expect = 5.261e-174
Identity = 240/341 (70.38%), Postives = 289/341 (84.75%), Query Frame = 1

Query:  169 EQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH---DVNNTLENSSKSDSGNSLKN 1182
            E PHIG Y+L+KTIGKGNFAKVKLA+HV T K+VAVK+IDKT LN+SSLQK+FREVRIMK ++HPNIVKLFEVIE+++ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F V  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  +MKD+W+N G+ED+ L+PYIEP+ +Y+DP R  IM  +GF+++E+ DSL   K+N V ATYLLLD+   +++  +  S KS  G+ L N
Sbjct:   42 EYPHIGNYRLLKTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLNSSSLQKVFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQIMKDRWMNVGYEDDDLKPYIEPQPDYKDPRRTDIMLQMGFSQEEIEDSLVKQKYNEVMATYLLLDYRNSELDEGVNLSLKSRPGSDLTN 382

HSP 2 Score: 59.6918 bits (143), Expect = 1.717e-8
Identity = 33/108 (30.56%), Postives = 58/108 (53.70%), Query Frame = 1

Query: 2515 NQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            +Q+KPR +   +    TS + P    SEMMK ++   + +  + E  + +++ C   +      ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  686 DQSKPRSLRFTWSMKTTSSMEP----SEMMKEIRKVLDANSCEYELRERYMLLC---MAGNPARDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 786

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: mark2 (microtubule affinity regulating kinase 2 [Source:NCBI gene;Acc:594939])

HSP 1 Score: 530.02 bits (1364), Expect = 8.314e-175
Identity = 271/458 (59.17%), Postives = 338/458 (73.80%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGN-SLK-----NVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMG-----TTTTHSNDEVPQLRQGSTRSK 1506
            +EQPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL +D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +M+D+W+N G E++ L+PY+EP  +Y+DP R  +M ++G+T++E+ DSL N K+N V ATYLLL +        SS++D+ N +LK     +V+N+++     K   S +AN      S  A  +  NS     K  + N +N+ S  ++      +   KS  + R P    PSP  G     TT T S + V  L  G+ RS+
Sbjct:   49 DEQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIVHRDLKAENLLLDSDMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPAKRGTLEQIMRDRWMNVGHEEDELKPYVEPIPDYKDPKRTELMITMGYTREEISDSLVNQKYNEVMATYLLLGY-------KSSETDNDNLTLKPRPPPDVTNSIAPSPAHKVQRSVSANPKQRRLSDQAGPAIPNSNSYSKKTQSNNAENRRSEDDK------ESGRKSSSTVRVP----PSPLSGLDRKKTTPTPSTNSV--LSTGTNRSR 487

HSP 2 Score: 55.8398 bits (133), Expect = 3.707e-7
Identity = 32/106 (30.19%), Postives = 56/106 (52.83%), Query Frame = 1

Query: 2521 NKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            +KPR +   +    TS + P  ++SE+ K L  ++     + E  + +++ C   +    G +  + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  685 SKPRSLRFTWSMKTTSSMEPNEMMSEIRKVLDANN----CQHESQEKYMLLC---VHGTPGHDNYVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 783

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: mark2 (microtubule affinity regulating kinase 2 [Source:NCBI gene;Acc:594939])

HSP 1 Score: 530.02 bits (1364), Expect = 8.895e-175
Identity = 271/458 (59.17%), Postives = 338/458 (73.80%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGN-SLK-----NVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMG-----TTTTHSNDEVPQLRQGSTRSK 1506
            +EQPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL +D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +M+D+W+N G E++ L+PY+EP  +Y+DP R  +M ++G+T++E+ DSL N K+N V ATYLLL +        SS++D+ N +LK     +V+N+++     K   S +AN      S  A  +  NS     K  + N +N+ S  ++      +   KS  + R P    PSP  G     TT T S + V  L  G+ RS+
Sbjct:   56 DEQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIVHRDLKAENLLLDSDMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPAKRGTLEQIMRDRWMNVGHEEDELKPYVEPIPDYKDPKRTELMITMGYTREEISDSLVNQKYNEVMATYLLLGY-------KSSETDNDNLTLKPRPPPDVTNSIAPSPAHKVQRSVSANPKQRRLSDQAGPAIPNSNSYSKKTQSNNAENRRSEDDK------ESGRKSSSTVRVP----PSPLSGLDRKKTTPTPSTNSV--LSTGTNRSR 494

HSP 2 Score: 55.8398 bits (133), Expect = 3.259e-7
Identity = 32/106 (30.19%), Postives = 56/106 (52.83%), Query Frame = 1

Query: 2521 NKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            +KPR +   +    TS + P  ++SE+ K L  ++     + E  + +++ C   +    G +  + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  683 SKPRSLRFTWSMKTTSSMEPNEMMSEIRKVLDANN----CQHESQEKYMLLC---VHGTPGHDNYVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 781

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: mark2 (microtubule affinity regulating kinase 2 [Source:NCBI gene;Acc:594939])

HSP 1 Score: 530.02 bits (1364), Expect = 1.169e-174
Identity = 271/458 (59.17%), Postives = 338/458 (73.80%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGN-SLK-----NVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMG-----TTTTHSNDEVPQLRQGSTRSK 1506
            +EQPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL +D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +M+D+W+N G E++ L+PY+EP  +Y+DP R  +M ++G+T++E+ DSL N K+N V ATYLLL +        SS++D+ N +LK     +V+N+++     K   S +AN      S  A  +  NS     K  + N +N+ S  ++      +   KS  + R P    PSP  G     TT T S + V  L  G+ RS+
Sbjct:   56 DEQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIVHRDLKAENLLLDSDMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPAKRGTLEQIMRDRWMNVGHEEDELKPYVEPIPDYKDPKRTELMITMGYTREEISDSLVNQKYNEVMATYLLLGY-------KSSETDNDNLTLKPRPPPDVTNSIAPSPAHKVQRSVSANPKQRRLSDQAGPAIPNSNSYSKKTQSNNAENRRSEDDK------ESGRKSSSTVRVP----PSPLSGLDRKKTTPTPSTNSV--LSTGTNRSR 494

HSP 2 Score: 55.8398 bits (133), Expect = 3.504e-7
Identity = 32/106 (30.19%), Postives = 56/106 (52.83%), Query Frame = 1

Query: 2521 NKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            +KPR +   +    TS + P  ++SE+ K L  ++     + E  + +++ C   +    G +  + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  692 SKPRSLRFTWSMKTTSSMEPNEMMSEIRKVLDANN----CQHESQEKYMLLC---VHGTPGHDNYVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 790

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:100329119])

HSP 1 Score: 514.612 bits (1324), Expect = 1.661e-169
Identity = 258/506 (50.99%), Postives = 345/506 (68.18%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDV---------------------NNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDM--NNGDNLAVP 1614
            +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TG++VA+K+IDKT LN +SLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F V  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLK+ L++NP KR TL  +MKD+WIN G E++ L+P++EP+ +  D  R+ IM  +G++++E+ +SL   K++ +TATYLLL                         N+ L NSS     +  +++S++  Q+ ++ HA             G A+ S T              ++Q ST +    + V +S KS  + R      PSP +G  +  +  ++P+ ++ S     N+      + N  + ++++  D+  +  N  +N  +P
Sbjct:   48 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSREEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPNSDLNNSSGQSPHHKGRSISSSQKQRRYSDHA-------------GPAVPSVT----------AYPKRSQTSTTDNDLKDEVGQSRKSSSTGR--GVTPPSPMLGNASNPNKADIPERKKSSVVPTSNSTSSGMTRRNTYVCSERAPTDRHSVIQNGKENSTIP 528

HSP 2 Score: 58.5362 bits (140), Expect = 5.084e-8
Identity = 41/143 (28.67%), Postives = 71/143 (49.65%), Query Frame = 1

Query: 2410 SQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            S+   R   +S + +GD     D+NK          ++KPR +   +    TS + P  ++ E+ K L +++  D+ + E+   F +   G  ++      L+ WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  616 SERNGRYEGSSRNVSGDQK---DENK----------ESKPRSLRFTWSMKTTSSMDPNDMMREIRKVL-DANNCDYEQRERFLLFCVHGDGHAEN------LVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 738

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:NCBI gene;Acc:100329119])

HSP 1 Score: 514.998 bits (1325), Expect = 2.031e-169
Identity = 258/506 (50.99%), Postives = 345/506 (68.18%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDV---------------------NNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDM--NNGDNLAVP 1614
            +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TG++VA+K+IDKT LN +SLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F V  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLK+ L++NP KR TL  +MKD+WIN G E++ L+P++EP+ +  D  R+ IM  +G++++E+ +SL   K++ +TATYLLL                         N+ L NSS     +  +++S++  Q+ ++ HA             G A+ S T              ++Q ST +    + V +S KS  + R      PSP +G  +  +  ++P+ ++ S     N+      + N  + ++++  D+  +  N  +N  +P
Sbjct:   48 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSREEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPNSDLNNSSGQSPHHKGRSISSSQKQRRYSDHA-------------GPAVPSVT----------AYPKRSQTSTTDNDLKDEVGQSRKSSSTGR--GVTPPSPMLGNASNPNKADIPERKKSSVVPTSNSTSSGMTRRNTYVCSERAPTDRHSVIQNGKENSTIP 528

HSP 2 Score: 58.5362 bits (140), Expect = 5.474e-8
Identity = 41/143 (28.67%), Postives = 71/143 (49.65%), Query Frame = 1

Query: 2410 SQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            S+   R   +S + +GD     D+NK          ++KPR +   +    TS + P  ++ E+ K L +++  D+ + E+   F +   G  ++      L+ WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  625 SERNGRYEGSSRNVSGDQK---DENK----------ESKPRSLRFTWSMKTTSSMDPNDMMREIRKVL-DANNCDYEQRERFLLFCVHGDGHAEN------LVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 747

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark2 (MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638])

HSP 1 Score: 527.709 bits (1358), Expect = 4.542e-175
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMLRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 53.9138 bits (128), Expect = 9.268e-7
Identity = 31/107 (28.97%), Postives = 55/107 (51.40%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G    + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  606 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHERYMLLC---VHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 705

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark2 (MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638])

HSP 1 Score: 527.324 bits (1357), Expect = 7.313e-175
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMLRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 53.9138 bits (128), Expect = 1.024e-6
Identity = 31/107 (28.97%), Postives = 55/107 (51.40%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G    + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  615 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHERYMLLC---VHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 714

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark2 (MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638])

HSP 1 Score: 527.324 bits (1357), Expect = 8.827e-175
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMLRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 53.9138 bits (128), Expect = 9.192e-7
Identity = 31/107 (28.97%), Postives = 55/107 (51.40%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G    + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  621 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHERYMLLC---VHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 720

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark2 (MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638])

HSP 1 Score: 527.709 bits (1358), Expect = 1.028e-174
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMLRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 53.9138 bits (128), Expect = 1.050e-6
Identity = 31/107 (28.97%), Postives = 55/107 (51.40%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G    + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  630 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHERYMLLC---VHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 729

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Mark2 (MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638])

HSP 1 Score: 528.48 bits (1360), Expect = 2.053e-174
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMLRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 54.299 bits (129), Expect = 8.322e-7
Identity = 31/107 (28.97%), Postives = 55/107 (51.40%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G    + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  675 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHERYMLLC---VHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 774

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|O08679|MARK2_RAT (Serine/threonine-protein kinase MARK2 OS=Rattus norvegicus OX=10116 GN=Mark2 PE=1 SV=1)

HSP 1 Score: 527.709 bits (1358), Expect = 4.723e-174
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMLRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 53.9138 bits (128), Expect = 6.826e-6
Identity = 31/107 (28.97%), Postives = 55/107 (51.40%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G    + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  621 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHERYMLLC---VHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 720

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q7KZI7|MARK2_HUMAN (Serine/threonine-protein kinase MARK2 OS=Homo sapiens OX=9606 GN=MARK2 PE=1 SV=2)

HSP 1 Score: 527.324 bits (1357), Expect = 5.302e-173
Identity = 238/333 (71.47%), Postives = 284/333 (85.29%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMIRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 55.4546 bits (132), Expect = 2.628e-6
Identity = 31/107 (28.97%), Postives = 56/107 (52.34%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G  + + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  687 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHEKYMLLC---MHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 786

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q05512|MARK2_MOUSE (Serine/threonine-protein kinase MARK2 OS=Mus musculus OX=10090 GN=Mark2 PE=1 SV=3)

HSP 1 Score: 525.013 bits (1351), Expect = 2.783e-172
Identity = 237/333 (71.17%), Postives = 283/333 (84.98%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH 1122
            N +   N+A S   +EQPHIG Y+L+KTIGKGNFAKVKLA+H+ TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+K +GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR TL  +MKD+W+N G ED+ L+PY+EP  +Y+DP R  +M S+G+T++E+ DSL   ++N V ATYLLL +
Sbjct:   33 NMLRGRNSATSA--DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKIDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 363

HSP 2 Score: 54.299 bits (129), Expect = 6.393e-6
Identity = 31/107 (28.97%), Postives = 55/107 (51.40%), Query Frame = 1

Query: 2518 QNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            + KPR +   +    TS + P    +EMM+ ++   + +  + E  + +++ C   +    G    + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  675 EAKPRSLRFTWSMKTTSSMEP----NEMMREIRKVLDANSCQSELHERYMLLC---VHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 774

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q96L34|MARK4_HUMAN (MAP/microtubule affinity-regulating kinase 4 OS=Homo sapiens OX=9606 GN=MARK4 PE=1 SV=1)

HSP 1 Score: 518.85 bits (1335), Expect = 3.723e-170
Identity = 252/458 (55.02%), Postives = 331/458 (72.27%), Query Frame = 1

Query:  169 EQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNV------SNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQ-ESFKSKLSNRSPNS--IKPSPSMGTTTTHSND-EVPQLRQGSTRSKPN 1512
            EQPH+G Y+L++TIGKGNFAKVKLA+H+ TG++VA+K+IDKT LN SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+ YCH K IVHRDLKAENLLL  +  IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVD+WSLGVILYTLVSGSLPFDGHN++ELRERVLRGKYR+PFYM+TDCE++L++ L++NP KR TL  +MKDKWIN G+E   L+PY EP++++ D  R+ +M  +G+T++E+ +SL + K+N VTATYLLL      T E   +   G +L  V      +N  S    T H+  + ++ ++  R       + +S   G   + ++ K   ++  E E    +    K+  S     S  + PS  M ++  + N  E+P+ R+ ST S PN
Sbjct:   52 EQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLG---RKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHR------QRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDST-STPN 499

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BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q8CIP4|MARK4_MOUSE (MAP/microtubule affinity-regulating kinase 4 OS=Mus musculus OX=10090 GN=Mark4 PE=1 SV=1)

HSP 1 Score: 516.538 bits (1329), Expect = 2.638e-169
Identity = 248/454 (54.63%), Postives = 327/454 (72.03%), Query Frame = 1

Query:  169 EQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSP-----NSIKPSPSMGTTTTHSND-EVPQLRQGSTRSKPN 1512
            EQPH+G Y+L++TIGKGNFAKVKLA+H+ TG++VA+K+IDKT LN SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+ YCH K IVHRDLKAENLLL  +  IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVD+WSLGVILYTLVSGSLPFDGHN++ELRERVLRGKYR+PFYM+TDCE++L++ L++NP KR TL  +MKDKWIN G+E   L+PY EP++++ D  R+ +M  +G+T++E+ ++L N K+N VTATYLLL      T E   +   G +L  V       + T  +   + N      S +    + +S   G   + ++ K   ++  + E    +E    + ++ S        + PS  M ++  + N  E+P+ R+ ST S PN
Sbjct:   52 EQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLG---RKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKGQRASSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELK--EERMPGRKASCSAVGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDST-STPN 499

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BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A183AFP0 (Uncharacterized protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS5775 PE=4 SV=1)

HSP 1 Score: 544.273 bits (1401), Expect = 5.362e-177
Identity = 243/350 (69.43%), Postives = 298/350 (85.14%), Query Frame = 1

Query:  160 KW---NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLS 1200
            +W   ++QPH+GKYK I+TIGKGNFAKVKLA HV TGK+VA+K+IDKT L+ SS QKLFREV +MK +DHPNIVKLFE+IE++R +YLVME+AS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K+I+HRDLKAENLLL +DL IK+ADFGFAN F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N+RELRERVLRGKYRIPFYM+TDCE+LLKKML++NP KR++L  VMKD+WINTG+EDN L PY+EP+ +Y DPVR+ IM ++GF +DE+L SL    F+++TATYLLL     ++LE+ S+  S  SL+  S+ +S
Sbjct:   55 RWRCIDDQPHVGKYKFIRTIGKGNFAKVKLASHVITGKEVAIKIIDKTQLSPSSRQKLFREVHLMKLLDHPNIVKLFEIIENDRILYLVMEFASGGEVFDYLVTHGRMKEKEARSKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSDLNIKLADFGFANEFSPGTKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLRELRERVLRGKYRIPFYMSTDCESLLKKMLVLNPAKRYSLEAVMKDRWINTGYEDNPLTPYVEPEPDYTDPVRIEIMVNMGFNRDEILKSLKQGNFDDITATYLLLGRR-RSSLESESRDGSSLSLRQSSHMIS 403

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BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A060WG75 (Uncharacterized protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00069394001 PE=4 SV=1)

HSP 1 Score: 533.872 bits (1374), Expect = 2.359e-176
Identity = 268/484 (55.37%), Postives = 341/484 (70.45%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDH---DVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPS----MGTTTTHS-NDEVPQ-----LRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDK 1578
            +EQPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YL+MEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  +MKD+W+N G E+  L+P+IEP+ +Y+DP R  IM  +G++ +E+ DSL N K+N V ATYLLLD+   +++  +  S KS  G+ L N SN  S     + +TS        T +GS+   ++     GD      D  +  +     +        +    RS     P+PS    + T T+ S N  VP+     ++ G   + P   R+P   P+ + +   +  D+
Sbjct:   13 DEQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTMGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQIMKDRWMNVGHEEEELKPFIEPQPDYKDPKRTDIMLQMGYSAEEIQDSLVNQKYNEVMATYLLLDYRNTEMDECISLSMKSRPGSDLTN-SNAQSPSHKVQRSTSSNLKPRRATEAGSSASKRS----QGDNKQTAEDYGRKGSGTGSSTKVPPSPLATADRKRS----TPTPSTNSILSTGTSRSRNSPVPERATLGVQNGKDSTAPQ--RVPVASPSAHNIGSSTATDR 485

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BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A210QE29 (Serine/threonine-protein kinase MARK2 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT10096 PE=4 SV=1)

HSP 1 Score: 533.102 bits (1372), Expect = 5.884e-176
Identity = 246/371 (66.31%), Postives = 306/371 (82.48%), Query Frame = 1

Query:  169 EQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALES 1281
            ++PHIGKY+LIKTIGKGNFAKVKLA+HV TG++VA+K+IDKT LN SSLQKLFREVRIMK +DHPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK L++NP KR +L ++MKD+WIN G+ED  L+PY EP K+  DP R+ IM ++G+++ ++ DS+ N K++++ ATYLLL    ++ LE S +S S  SL+++  + S + H+++  +   +   VTRS SA  S
Sbjct:   38 DEPHIGKYRLIKTIGKGNFAKVKLAKHVPTGREVAIKIIDKTQLNPSSLQKLFREVRIMKLLDHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDGDMNIKIADFGFSNEFVPGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVLNPTKRASLENIMKDRWINMGYEDRELKPYREPPKDLVDPKRIEIMVNMGYSRKDIEDSITNQKYDDIQATYLLLGRRSSD-LEGSDRSGSSQSLRHLPLSSSNRPHSENTANNNTSPNKVTRSQSATTS 407

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BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A484CDQ5 (Non-specific serine/threonine protein kinase OS=Perca flavescens OX=8167 GN=EPR50_G00198560 PE=4 SV=1)

HSP 1 Score: 538.11 bits (1385), Expect = 3.292e-175
Identity = 270/500 (54.00%), Postives = 353/500 (70.60%), Query Frame = 1

Query:  136 AENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSN-------NLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSND----EVPQLRQGSTRSKPNA--IRIPGIQPNINLVAQKSNVDKPDMNNG 1596
              N+  +   ++QPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  +M+D+W+N G E+  L+PYIEP+ +Y+DP R  IM ++GF+++E+ DSL N K+N+V A YLLLD+  +   E   K   G+ + N++          S   + K    +A +  S ++ G   +++T  + +G K S        S+  +  ++ +  S + K +  S NSI     + T T+ S +    E   L QG    K +A   R PG  P+ + ++  +  D+ + + G
Sbjct:   30 CRNSVATTTTDDQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKMLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGSLEQIMRDRWMNVGHEEEELKPYIEPQPDYKDPRRTDIMLTMGFSQEEIQDSLVNQKYNDVMAAYLLLDYRNSELDEGGIKPRQGSDVSNINAPSPPHKVQRSVSSNQKPQNRRATDQGSYSKRGGQSDNRTAGEDSGRKGSG-------SSTTKVPASPLVPSDRKKSATPSTNSI-----LSTGTSRSRNSPLTERATLGQGIQNGKDSAPTQRAPGASPSAHNISSAAASDRTNFSRG 517

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BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A4E0RY34 (Non-specific serine/threonine protein kinase OS=Fasciola hepatica OX=6192 GN=D915_002194 PE=4 SV=1)

HSP 1 Score: 550.821 bits (1418), Expect = 3.710e-175
Identity = 253/386 (65.54%), Postives = 311/386 (80.57%), Query Frame = 1

Query:  160 KW---NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGD 1308
            +W   ++QPH+GKYK I+TIGKGNFAKVKLA HV TGK+VA+K+IDKT L+ SS QKLFREVR+MK +DHPNIVKLFE+IE++R +YLVME+AS GEVFDYLV NGRMKEK+AR +FR+IVSA+QYCH K+I+HRDLKAENLLL +DL IK+ADFGFAN F+   +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N+RELRERVLRGKYRIPFYM+TDCE+LLKKML++NP KR++L  VMKD+WINTG+EDN L PY+EP+ +Y DPVR+ IM ++GF +DEVL SL    F+++TATYLLL     ++LE+ S+  S  SL+       Q +H   + S +A   S     S     T++  +GD
Sbjct:   36 RWRCIDDQPHVGKYKFIRTIGKGNFAKVKLASHVITGKEVAIKIIDKTQLSPSSRQKLFREVRLMKLLDHPNIVKLFEIIENDRILYLVMEFASGGEVFDYLVTNGRMKEKEARSKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSDLNIKLADFGFANEFNPGTKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLRELRERVLRGKYRIPFYMSTDCESLLKKMLVLNPAKRYSLEAVMKDRWINTGYEDNPLTPYVEPEPDYTDPVRIEIMVNMGFNRDEVLQSLKQGNFDDITATYLLLGRR-RSSLESESRDGSSLSLR-------QSNHMISSVSASAVGPSGNYGPSLPSEVTSNAASGD 413

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark2a (MAP/microtubule affinity-regulating kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-4145])

HSP 1 Score: 528.865 bits (1361), Expect = 8.404e-175
Identity = 255/410 (62.20%), Postives = 314/410 (76.59%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLS------------IMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSL------KNVSNNLSQK--DHTKHATSK--------AANDASVTRSGSALESKTNSKVNGDK 1311
            +EQPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  VMKD+W+N G+E+  L+PYIEP+ +Y+DP R              IM  +G++++E+ DSL N K++ + ATYLLLD+  +   E ++KS  G  L      ++ SN  S++  D +  ATSK        AA +     SGS+ +   +    GD+
Sbjct:   42 DEQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQVMKDRWMNVGYEEEELKPYIEPQPDYKDPKRTGQHPSSAGGWKRDIMLQMGYSQEEIQDSLVNQKYDEIMATYLLLDYRNSELDEITTKSRPGIDLTSNAVQRSTSNQKSRRSTDQSSSATSKRSQGDSKHAAEEYGRKSSGSSAKVPPSPLTTGDR 451

HSP 2 Score: 57.3806 bits (137), Expect = 6.624e-8
Identity = 33/105 (31.43%), Postives = 57/105 (54.29%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P  ++ E+ K L +S+  D+   E+   F++ C   +  +   ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  669 KPRSLRFTWSMKTTSSMEPNEMMKEIRKVL-DSNSCDYELRER---FMLLC---MSGKPSRDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 766

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark2a (MAP/microtubule affinity-regulating kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-4145])

HSP 1 Score: 527.709 bits (1358), Expect = 8.789e-175
Identity = 255/410 (62.20%), Postives = 314/410 (76.59%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLS------------IMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSL------KNVSNNLSQK--DHTKHATSK--------AANDASVTRSGSALESKTNSKVNGDK 1311
            +EQPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  VMKD+W+N G+E+  L+PYIEP+ +Y+DP R              IM  +G++++E+ DSL N K++ + ATYLLLD+  +   E ++KS  G  L      ++ SN  S++  D +  ATSK        AA +     SGS+ +   +    GD+
Sbjct:   42 DEQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQVMKDRWMNVGYEEEELKPYIEPQPDYKDPKRTGQHPSSAGGWKRDIMLQMGYSQEEIQDSLVNQKYDEIMATYLLLDYRNSELDEITTKSRPGIDLTSNAVQRSTSNQKSRRSTDQSSSATSKRSQGDSKHAAEEYGRKSSGSSAKVPPSPLTTGDR 451

HSP 2 Score: 57.3806 bits (137), Expect = 7.676e-8
Identity = 33/105 (31.43%), Postives = 57/105 (54.29%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P  ++ E+ K L +S+  D+   E+   F++ C   +  +   ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  643 KPRSLRFTWSMKTTSSMEPNEMMKEIRKVL-DSNSCDYELRER---FMLLC---MSGKPSRDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 740

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark2a (MAP/microtubule affinity-regulating kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-4145])

HSP 1 Score: 529.25 bits (1362), Expect = 9.163e-175
Identity = 255/410 (62.20%), Postives = 314/410 (76.59%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLS------------IMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSL------KNVSNNLSQK--DHTKHATSK--------AANDASVTRSGSALESKTNSKVNGDK 1311
            +EQPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  VMKD+W+N G+E+  L+PYIEP+ +Y+DP R              IM  +G++++E+ DSL N K++ + ATYLLLD+  +   E ++KS  G  L      ++ SN  S++  D +  ATSK        AA +     SGS+ +   +    GD+
Sbjct:   42 DEQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQVMKDRWMNVGYEEEELKPYIEPQPDYKDPKRTGQHPSSAGGWKRDIMLQMGYSQEEIQDSLVNQKYDEIMATYLLLDYRNSELDEITTKSRPGIDLTSNAVQRSTSNQKSRRSTDQSSSATSKRSQGDSKHAAEEYGRKSSGSSAKVPPSPLTTGDR 451

HSP 2 Score: 57.3806 bits (137), Expect = 6.558e-8
Identity = 33/105 (31.43%), Postives = 57/105 (54.29%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P  ++ E+ K L +S+  D+   E+   F++ C   +  +   ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  682 KPRSLRFTWSMKTTSSMEPNEMMKEIRKVL-DSNSCDYELRER---FMLLC---MSGKPSRDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 779

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark2a (MAP/microtubule affinity-regulating kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-4145])

HSP 1 Score: 528.865 bits (1361), Expect = 9.627e-175
Identity = 255/410 (62.20%), Postives = 314/410 (76.59%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLS------------IMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSL------KNVSNNLSQK--DHTKHATSK--------AANDASVTRSGSALESKTNSKVNGDK 1311
            +EQPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  VMKD+W+N G+E+  L+PYIEP+ +Y+DP R              IM  +G++++E+ DSL N K++ + ATYLLLD+  +   E ++KS  G  L      ++ SN  S++  D +  ATSK        AA +     SGS+ +   +    GD+
Sbjct:   42 DEQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQVMKDRWMNVGYEEEELKPYIEPQPDYKDPKRTGQHPSSAGGWKRDIMLQMGYSQEEIQDSLVNQKYDEIMATYLLLDYRNSELDEITTKSRPGIDLTSNAVQRSTSNQKSRRSTDQSSSATSKRSQGDSKHAAEEYGRKSSGSSAKVPPSPLTTGDR 451

HSP 2 Score: 57.7658 bits (138), Expect = 4.897e-8
Identity = 43/152 (28.29%), Postives = 74/152 (48.68%), Query Frame = 1

Query: 2383 PWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            P  PM +   + EK    ++ D   D+ SS     +  + T      KPR +   +    TS + P  ++ E+ K L +S+  D+   E+   F++ C   +  +   ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  631 PRRPMLSTADKMEKGTQGSAGDDNKDSVSSSSPVSSTPSSTQSAKDTKPRSLRFTWSMKTTSSMEPNEMMKEIRKVL-DSNSCDYELRER---FMLLC---MSGKPSRDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 775

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: mark2a (MAP/microtubule affinity-regulating kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030131-4145])

HSP 1 Score: 528.48 bits (1360), Expect = 2.367e-174
Identity = 255/410 (62.20%), Postives = 314/410 (76.59%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLS------------IMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSL------KNVSNNLSQK--DHTKHATSK--------AANDASVTRSGSALESKTNSKVNGDK 1311
            +EQPHIG Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L  VMKD+W+N G+E+  L+PYIEP+ +Y+DP R              IM  +G++++E+ DSL N K++ + ATYLLLD+  +   E ++KS  G  L      ++ SN  S++  D +  ATSK        AA +     SGS+ +   +    GD+
Sbjct:   42 DEQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQVMKDRWMNVGYEEEELKPYIEPQPDYKDPKRTGQHPSSAGGWKRDIMLQMGYSQEEIQDSLVNQKYDEIMATYLLLDYRNSELDEITTKSRPGIDLTSNAVQRSTSNQKSRRSTDQSSSATSKRSQGDSKHAAEEYGRKSSGSSAKVPPSPLTTGDR 451

HSP 2 Score: 58.5362 bits (140), Expect = 2.880e-8
Identity = 61/222 (27.48%), Postives = 100/222 (45.05%), Query Frame = 1

Query: 2194 PAGPELNINETLSPYDNSEVSQQFRRYSTG------DKLIRR-LTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            PA P L+       + NS+V    RR  TG       K +RR L+ + P S    +  +E S           PM +   + EK    ++ D   D+ SS     +  + T      KPR +   +    TS + P  ++ E+ K L +S+  D+   E+   F++ C   +  +   ++ + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  594 PASPSLS-------HGNSQV----RRPGTGIFSKFTSKFVRRNLSFRFPRSPYEGEGRDEAS----------RPMLSTADKMEKGTQGSAGDDNKDSVSSSSPVSSTPSSTQSAKDTKPRSLRFTWSMKTTSSMEPNEMMKEIRKVL-DSNSCDYELRER---FMLLC---MSGKPSRDDFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 787

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006410.1 (pep scaffold:Pmarinus_7.0:GL476370:17405:31068:-1 gene:ENSPMAG00000005688.1 transcript:ENSPMAT00000006410.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 501.13 bits (1289), Expect = 3.278e-166
Identity = 220/316 (69.62%), Postives = 272/316 (86.08%), Query Frame = 1

Query:  169 EQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            E PHIG Y+L+KTIGKGNFAKVKLA+H+ TG++VA+K+IDKT LN +SLQKLFREVRIMK ++HPNIVKL+EVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRE+VLRGKYRIPFYM+TDCE LLK+ L++NP+KR +L  +M+D+W+N G E++ L+PY EP+ +  D  R+ IM  +G+T DE++ SL   K++ + ATYLLL
Sbjct:   32 ELPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKCLNHPNIVKLYEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKNIVHRDLKAENLLLDVDMHIKIADFGFSNEFTLVNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELREKVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGSLEQIMRDRWMNVGHEEDELKPYQEPELDINDQKRIEIMIGMGYTMDEIVGSLSAKKYDEIMATYLLL 347

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 505.368 bits (1300), Expect = 5.690e-166
Identity = 231/336 (68.75%), Postives = 280/336 (83.33%), Query Frame = 1

Query:  169 EQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSL 1176
            E  HIG Y+L+KTIGKGNFAKVKLA+H  TG++VAVK+IDKT LN SSLQKLFREVRIMK ++HPNIVKLFEVIE+E+ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLK+ L++NP KR +L  +MKD+W+N G E++ L+PY+EP  +  D  R+  M  +G+++DE+ DSL N K++ + ATYLLL    +  LE S  S SG++L
Sbjct:   47 EHAHIGTYRLLKTIGKGNFAKVKLARHTLTGREVAVKIIDKTQLNPSSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGSLEQIMKDRWMNVGHEEDELKPYVEPTLDINDTKRIETMVEMGYSRDEIRDSLTNMKYDEILATYLLLGRKPSE-LEGSD-SCSGSNL 380

HSP 2 Score: 63.929 bits (154), Expect = 1.416e-10
Identity = 42/122 (34.43%), Postives = 66/122 (54.10%), Query Frame = 1

Query: 2488 AHQNYTLK----PNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIEC-QGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            AH+  T K    P  +KPR +   +    TS + P  ++ E+ K L N +  D+   EQ + +++ C  G+ +S  G  E + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  685 AHRGGTSKLREEPRDSKPRSLRFTWSMKTTSSMEPGEMMREIRKVLDN-NACDY---EQREPYLLYCAHGETRS--GAEEPVTWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 800

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 491.5 bits (1264), Expect = 7.917e-166
Identity = 233/384 (60.68%), Postives = 294/384 (76.56%), Query Frame = 1

Query:  133 NAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESK 1284
            +AE+A   +   ++  +G Y+L+KTIGKGNFAKVKLA+H  TG++VAVK+IDKT LN SSLQKLFREVRIMK ++HPNIVKLFEVIE E+ +YLVMEY+S GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  D+ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLK+ L+++P+KR +L  +MKD+W+N   ED+ L+PY+EP  +  D  R+  M  +GF ++++  SL   K++++TATYLLL        E    SDSG++        +  D    ++  AA    V RS SA + +
Sbjct:   51 SAEDAQPPSGQTQR--VGNYRLLKTIGKGNFAKVKLAKHTLTGQEVAVKIIDKTQLNTSSLQKLFREVRIMKVLNHPNIVKLFEVIEMEKTLYLVMEYSSGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLHPLKRGSLEQIMKDRWMNVKHEDDELKPYLEPSLDIGDTKRIDFMVGMGFAREKITKSLSEMKYDDITATYLLL----GRKQEMGDGSDSGSTQSLSIKPRASSDVHNGSSGSAAAHGKVQRSSSAAQKQ 428

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: snrka (SNF related kinase a [Source:ZFIN;Acc:ZDB-GENE-040718-84])

HSP 1 Score: 253.832 bits (647), Expect = 1.299e-73
Identity = 130/321 (40.50%), Postives = 204/321 (63.55%), Query Frame = 1

Query:  184 GKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFR-EVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQN-GRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLL-SNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKW---INTGFEDNLLQPYIEPKKNYEDP----VRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            G Y L KT+G+G+FA VKLA+HV TG+KVAVKVIDK+ L+  +   LF+ EVR MK + HPN+V+L+EVI+++  +YL++E A  G+++DY++++ G ++E+ A+  F ++V AI YCH   +VHRDLK EN++       +K+ DFGF+N F    +L T CGS  Y+APE+  G +Y+ P VD+WSLGVILY LV G  PF   N  E    ++  KY +P +++ +C+ L+ +ML  +P +R +L ++    W   ++         P I  K   ED     V+  ++ S+   +D ++++L   ++N++TATY LL
Sbjct:   14 GLYDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKSKLDPMATSHLFQQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELADGGDLYDYIMRHEGGLQEELAKTYFAQVVHAISYCHRLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNLFQPGTKLATSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILYMLVCGHPPFQEANDSETLTMIMDCKYTVPAHISRECKDLIARMLQRDPRRRASLQEMEGHPWLCGVDPSPAAKCSTPLISYKSLSEDEHNGIVQRMVLGSIA-ERDAIVEALEADRYNHITATYFLL 333

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: NIM1K (NIM1 serine/threonine protein kinase [Source:HGNC Symbol;Acc:HGNC:28646])

HSP 1 Score: 227.639 bits (579), Expect = 1.147e-66
Identity = 103/267 (38.58%), Postives = 168/267 (62.92%), Query Frame = 1

Query:  181 IGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPY 981
            I  Y++   IG GNF++VKL  H+ T  KVA+K++DK+ ++  +L  L  E+  M+ + HPN+V+L+EV+++   ++LVMEYA  GE+F  +   G +   +A+L F +I +A+++ H   +VHRDLKAEN+  + +  +K+ DFGF+      ++L TFCGSPPYAAPELF+ + Y GP+VDVW+LGV+L+ + SG+LPF    + +L+  +L G + +P  +   C  L+  +L   P +R T   +++ +W+          PY
Sbjct:   40 ISFYRIRGEIGSGNFSQVKLGVHLLTRDKVAIKLLDKSRMDERTLCLLSCEILAMELLRHPNVVRLYEVVDTPSRLHLVMEYAPGGELFTRVSTVGALPHDEAKLVFAQITAAVKHMHECGVVHRDLKAENVFYAGNCWVKVGDFGFSTTVTPNERLSTFCGSPPYAAPELFRDQSYLGPQVDVWALGVLLFFIASGTLPFRADTVGKLKLSILDGCFSVPLRVPASCCNLITTILRPLPDERPTAAQILRSEWLRGIHAPEPYPPY 306

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: SNF1 (AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase [Source:SGD;Acc:S000002885])

HSP 1 Score: 290.812 bits (743), Expect = 4.872e-87
Identity = 153/396 (38.64%), Postives = 240/396 (60.61%), Query Frame = 1

Query:  178 HIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQ-KLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYE------------------DPVRLSIMKS-LGFTKDEVLDSLYNAK----FNNVTATYLLLDHD---VNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDAS---VTRSGSAL 1275
            HIG Y+++KT+G+G+F KVKLA H TTG+KVA+K+I+K  L  S +Q ++ RE+  ++ + HP+I+KL++VI+S+  + +V+EYA   E+FDY+VQ  +M E++AR  F++I+SA++YCH  +IVHRDLK ENLLL   L +KIADFG +N       L T CGSP YAAPE+  G+ Y GPEVDVWS GVILY ++   LPFD  ++  L + +  G Y +P +++     L+K+MLIVNP+ R ++ ++M+D W      + LL P ++P    E                  D   ++I+ S +G+ KDE+ +SL +++    FN +   Y+L+  +   + +   N S SD  ++  + S    Q+    H  S+  ++ +     R  SA+
Sbjct:   51 HIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAG-NELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLPPDLKPHPEEENENNDSKKDGSSPDNDEIDDNLVNILSSTMGYEKDEIYESLESSEDTPAFNEIRDAYMLIKENKSLIKDMKANKSVSDELDTFLSQSPPTFQQQSKSHQKSQVDHETAKQHARRMASAI 445

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086])

HSP 1 Score: 245.358 bits (625), Expect = 7.577e-68
Identity = 113/306 (36.93%), Postives = 183/306 (59.80%), Query Frame = 1

Query:  124 NDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTAL-------------NNSSL--------------QKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFE 960
            ND +  N A   +   +  +G ++ ++T+G G+  KVKL +H  T +   +K++++ +              N S +              ++  RE  + + + HP+I +LFE+     H Y++ EY S G++ DY++Q+G +KE  AR   R I SA+QY H   IVHRDLK EN+++S+  +IKI DFG +N FD +KQL TFCGS  +AAPEL + + Y GPEVD+WS G++LY LV G +PFD  N   L E++ +GK   P +++ +  +LL +M++V+P++R TL +V++  W+N G++
Sbjct:   77 NDASRPNGAVELRQFHRRSLGDWEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGYD 382

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529])

HSP 1 Score: 238.424 bits (607), Expect = 9.797e-66
Identity = 112/286 (39.16%), Postives = 171/286 (59.79%), Query Frame = 1

Query:  181 IGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVID---KTALNNSSL------------------------QKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGF 957
            +G ++ ++T+G G+  KVKLA+H  T +  AVK+++   K  L+   +                        ++  RE  + + + HP+I +LFE+     H Y++ EY S G++ DY++Q+G ++E  AR   R I SA+ Y H   IVHRDLK EN+++S+  +IKI DFG +N +D +KQL TFCGS  +AAPEL +   Y GPEVDVWS GV+L+ LV G +PFD  N   L E++ +GK   P +++ +  +LL KML+V+P +R TL  V++  W+  GF
Sbjct:  117 LGDWEFVETVGAGSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQKKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQHLSIEVISLLSKMLVVDPKRRATLKQVVEHHWMVRGF 402

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: KCC4 (Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication [Source:SGD;Acc:S000000529])

HSP 1 Score: 232.646 bits (592), Expect = 8.242e-64
Identity = 117/263 (44.49%), Postives = 170/263 (64.64%), Query Frame = 1

Query:  181 IGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQK---------LFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGH--NMRELRERVLRGKYRIP--FYMTTDCETLLKKMLIVNPMKRFTLLDVM 930
            IG +KL +T+G G+  KV+LAQH  TG + AVKVI K+  NN+             + RE+ IMK + HPN++ L++V E+  ++YL++EYA +GE+F+ LV +G + E++A   FR+I+  I YCH   IVHRDLK ENLLL +   IKIADFG A        L+T CGSP YAAPE+  G  YEG   DVWS GVIL+ L++G LPFD    N+R+L  +V +G++ +P    ++ D + L+ K+L+V+P +R  + D++
Sbjct:   18 IGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDIL 280

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: HSL1 (Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; autophosphorylation enhances interactions with Hsl7p [Source:SGD;Acc:S000001584])

HSP 1 Score: 230.335 bits (586), Expect = 1.804e-62
Identity = 117/304 (38.49%), Postives = 178/304 (58.55%), Query Frame = 1

Query:  145 AAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTAL-----NNSSLQKLF-------------------------------REVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLL-SNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWI 945
            A KS+K   +  +G +KL KT+GKG+  +V+LA+++ TG+  A+K++ K        NN ++   +                               RE+ IMK I H N++ LFEV E++  +YLV+EY   GE+FDYLV  G++ E++A   F++IV  + YCH   I HRDLK ENLLL   + +IKIADFG A      K L T CGSP YA+PE+  GR Y G   DVWS G++L+ L++G LPF+  N+++L  +V  GKY++P  ++++   L+ K+L+++P KR T  +++K   I
Sbjct:   66 ATKSSKRKSRDTVGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPNSYSSSMVTSNVSSPSIASREHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQMPSNLSSEARDLISKILVIDPEKRITTQEILKHPLI 369

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO30768 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZV3])

HSP 1 Score: 499.975 bits (1286), Expect = 1.270e-165
Identity = 228/329 (69.30%), Postives = 272/329 (82.67%), Query Frame = 1

Query:  166 NEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSS 1152
            +E+ HIG+Y+LIKTIGKGNFAKVKLA+HV TGK+VA+K+IDKT LN SSLQKLFREVRIMK +DHPNIVKL+EVIE+++ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K ++HRDLKAENLLL  D+ IKIADFGF+N F    +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK L++NP KR  L   M DKW+N  +E N L+PY+EP     D  R+ IM  +GFT+DE+ ++L N +++ V ATYLLLD        N S
Sbjct:   30 SEEVHIGRYRLIKTIGKGNFAKVKLAKHVPTGKEVAIKIIDKTQLNPSSLQKLFREVRIMKFLDHPNIVKLYEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHVIHRDLKAENLLLDADMNIKIADFGFSNEFTPGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVLNPQKRARLEQTMTDKWMNINYELNELKPYLEPSAELNDERRIDIMLQMGFTRDEIYEALSNNRYDEVMATYLLLDEKRQGLTRNVS 358

HSP 2 Score: 59.3066 bits (142), Expect = 5.887e-9
Identity = 38/111 (34.23%), Postives = 60/111 (54.05%), Query Frame = 1

Query: 2506 LKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            L+    KPR +   +    TS + P  +I E+MK L+ ++  D+   EQ + +++ C     +E   N  + WE+EV +LPR S  G+R K+ SGSS  FK I   + N+L
Sbjct:  547 LRDTNEKPRSLRFTWSMKTTSTMDPYDMIREIMKVLE-ANNCDY---EQREKYLLLCCHGSPAE---NNHVQWEMEVCKLPRLSLNGVRFKRISGSSINFKNIASKVANEL 650

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO46035 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR22])

HSP 1 Score: 360.147 bits (923), Expect = 1.793e-116
Identity = 174/319 (54.55%), Postives = 237/319 (74.29%), Query Frame = 1

Query:  181 IGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWIN--TGFEDNLLQP-YIEPKKN----YEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            IG Y + KTIGKGNFA VKLA H  T  KVAVK+IDK+ L++ +L K+ REV++MK + HP+I+KL EV+E+ER +YLV EYAS+GE+FDYLV +GRM+EK+A+  F +IVSAI+YCH   IVHRDLKAENLLL  D+ IKIADFGF+N F   K+L T+CGSPPYAAPELF+G++Y GPEVD+WSLGV+LY LV G+LPFDG  ++ LR RVL G++RIPF+M+T+CE L++ ML+ +P+KRFT+  + + KW+   TG ++    P YI          ED +R   MK++GF +++ + ++ N  +++    Y LL
Sbjct:   17 IGFYNIEKTIGKGNFAVVKLATHCITKSKVAVKIIDKSQLDDDNLTKVKREVKVMKKLAHPHIIKLHEVMETERMLYLVTEYASKGEIFDYLVAHGRMQEKEAKNTFNQIVSAIEYCHKMNIVHRDLKAENLLLDEDMNIKIADFGFSNIFQADKKLKTWCGSPPYAAPELFEGKEYLGPEVDIWSLGVVLYVLVCGALPFDGSTLQSLRSRVLDGRFRIPFFMSTECEHLIRHMLVRDPVKRFTIPQIRQHKWMAEVTGKKNKEENPLYIHESCQDVDIREDVIRK--MKNMGFDREKTIQAIKNKDYDHNAGVYSLL 333

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO31932 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI1])

HSP 1 Score: 307.76 bits (787), Expect = 7.183e-96
Identity = 154/336 (45.83%), Postives = 222/336 (66.07%), Query Frame = 1

Query:  181 IGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIA-----------------DFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTG-------FEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLL 1116
            +G Y++ KTIGKGNF+ VKLA+H  T  +VA+K+IDKT LN  +L+K++REV+IMK + HP+IVKL++V+E++  +YLV +YA+ GE+FDYL  +GR+ EK+AR +F +I+SA+ YCH + +VHRDLKAENLLL  ++ IKIA                 DFGF N +     L+T+CGSPPYAAPE      Y  P+VD W LGV+LY LV G+LPFDG  ++ LR+RVL GK+RIPF+M+T+CE L++ ML+ +P +R+T+  + K KW+           E ++ +      ++Y +   L +MK LG        +L +  F++ TA Y LL
Sbjct:    9 VGFYEIDKTIGKGNFSVVKLARHRITKSQVAIKIIDKTQLNEMNLKKIYREVQIMKLLQHPHIVKLYQVMETKNMLYLVTDYANNGEMFDYLAHHGRLPEKEARKKFVQILSAVDYCHKRHVVHRDLKAENLLLDQNMNIKIAGMSGLYLVIHCILFSSLDFGFGNYYKPGNPLNTWCGSPPYAAPE----HIYCEPKVDFWPLGVVLYVLVCGALPFDGSTLQALRDRVLEGKFRIPFFMSTECEHLIRHMLVKDPNQRYTIEQIQKHKWLQAADSQKISEIEQSMREFEKISMEDYNEQA-LELMKGLGIDIKRTKKALDDNTFDHHTAIYYLL 339

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO36587 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SI81])

HSP 1 Score: 251.136 bits (640), Expect = 1.672e-75
Identity = 133/318 (41.82%), Postives = 197/318 (61.95%), Query Frame = 1

Query:  184 GKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGR-MKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLL-SNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQ--PYIE--PKKNYEDPVRLSIMKSLGFT-KDEVLDSLYNAKFNNVTATYLLL 1116
            G Y L +T+G+G+FA VK+A+HV TG++VAVKVIDKT L+  S + L +EVR MK + HPN+V+L++VI++   +YL++E    G+++DY++ + + + E+ AR  FR+IV AI YCH   +VHRDLK EN++   N    K+ DFGF+NNF   ++LDT CGS  Y+APE+  G  YE P VDVWSLGVILY LV G  PF   N  E   +++  +Y +P +++  C+ L+ +MLI  P  R +L ++M   W+  G    +    P +   P    E  + L  M+      +D+V+ SL    ++   ATY LL
Sbjct:   17 GMYDLGETLGRGHFAVVKVARHVITGERVAVKVIDKTKLDEVSREHLLKEVRCMKLVQHPNVVRLYQVIDTNTKLYLILELGDGGDMYDYIMNHDKGLPEEKARYFFRQIVLAIDYCHKLHVVHRDLKPENVIFFKNQDMAKLTDFGFSNNFIPNEKLDTACGSLAYSAPEVLLGDAYEAPAVDVWSLGVILYMLVCGQAPFSEANDSETLTKIMDCRYDVPDHVSPLCKNLISRMLIREPHNRASLGEIMSHPWLQQGPTPLVPSDVPLVAELPLTTDEHLLLLDKMEDGNIADRDKVIRSLEENSYDFTAATYFLL 334

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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO36169 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJE6])

HSP 1 Score: 257.684 bits (657), Expect = 1.805e-75
Identity = 130/317 (41.01%), Postives = 201/317 (63.41%), Query Frame = 1

Query:  181 IGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNN-SSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKN-YEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNV--TATYLLLD 1119
            IG Y L +T+G G F KVKLA H  TG KVA+K++++  + +   + K+ RE++ +K   HP+I+KL++VI +   +++VMEY S GE+F+Y++++G+++EKDAR  F++I+S + YCH   +VHRDLK ENLLL + L IKIADFG +N     + L T CGSP YAAPE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L  ++  G + +P ++++   +LL  ML V+P+KR T+  + +D W  T     L  P  E   N  +D     + + +   K +V+ +L     ++    A +L+LD
Sbjct:   17 IGNYNLGETLGVGTFGKVKLAVHQLTGHKVAIKILNRNKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPTDIFMVMEYVSGGELFEYILKHGKLEEKDARRFFQQIISGVDYCHRHMVVHRDLKPENLLLDSQLNIKIADFGLSNIMTDGEFLQTSCGSPNYAAPEVISGKLYAGPEVDIWSAGVILYALLCGTLPFDDEHIPTLFRKIKGGVFHVPPHLSSGPASLLNAMLNVDPIKRATVQFIKEDDWFKTELPGYLF-PATELGSNVVDDECMAQVCEKMNCQKGDVITALNCGDAHDQLRVAYHLILD 332

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark2b (microtubule affinity regulating kinase 2 [Source:NCBI gene;Acc:101172533])

HSP 1 Score: 525.013 bits (1351), Expect = 1.344e-173
Identity = 246/399 (61.65%), Postives = 305/399 (76.44%), Query Frame = 1

Query:  136 AENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTL-LDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNIND 1329
              N+  +   +EQPHIG+Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+++ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  ++ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L   +M+D+W+N G+E+  L+PYIEP+ +Y+DP R  +M  +G++++E+ DSL N K+N V ATYLLLD+  +   E   K   G+    +  N S   H    +  +   A   R    + S +     GD  S   D
Sbjct:   30 CRNSVATTTSDEQPHIGQYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDAEMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGSLEQQIMRDRWMNVGYEEEELKPYIEPQPDYKDPRRTDVMLQMGYSQEEIKDSLVNQKYNEVMATYLLLDYKNSELEEGCIKPRPGSDASTI--NASSPSHKVQRSVSSNQKAQSRRPTDQVSSYSKRGGPGDSRSAAED 426

HSP 2 Score: 53.1434 bits (126), Expect = 1.465e-6
Identity = 32/105 (30.48%), Postives = 56/105 (53.33%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P  ++ E+ K L +S+  D+ + E+   +++ C     +    +  + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  652 KPRSLRFTWSMKTTSSMEPAEMMREIRKVL-DSNNCDYDERER---YMLLC-----TSSDPHNFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 747

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark2b (microtubule affinity regulating kinase 2 [Source:NCBI gene;Acc:101172533])

HSP 1 Score: 525.398 bits (1352), Expect = 2.225e-173
Identity = 246/399 (61.65%), Postives = 305/399 (76.44%), Query Frame = 1

Query:  136 AENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTL-LDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNIND 1329
              N+  +   +EQPHIG+Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+++ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  ++ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L   +M+D+W+N G+E+  L+PYIEP+ +Y+DP R  +M  +G++++E+ DSL N K+N V ATYLLLD+  +   E   K   G+    +  N S   H    +  +   A   R    + S +     GD  S   D
Sbjct:   30 CRNSVATTTSDEQPHIGQYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDAEMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGSLEQQIMRDRWMNVGYEEEELKPYIEPQPDYKDPRRTDVMLQMGYSQEEIKDSLVNQKYNEVMATYLLLDYKNSELEEGCIKPRPGSDASTI--NASSPSHKVQRSVSSNQKAQSRRPTDQVSSYSKRGGPGDSRSAAED 426

HSP 2 Score: 53.5286 bits (127), Expect = 1.140e-6
Identity = 32/105 (30.48%), Postives = 56/105 (53.33%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P  ++ E+ K L +S+  D+ + E+   +++ C     +    +  + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  680 KPRSLRFTWSMKTTSSMEPAEMMREIRKVL-DSNNCDYDERER---YMLLC-----TSSDPHNFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 775

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark2b (microtubule affinity regulating kinase 2 [Source:NCBI gene;Acc:101172533])

HSP 1 Score: 525.398 bits (1352), Expect = 3.288e-173
Identity = 246/399 (61.65%), Postives = 305/399 (76.44%), Query Frame = 1

Query:  136 AENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTL-LDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNIND 1329
              N+  +   +EQPHIG+Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+++ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  ++ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L   +M+D+W+N G+E+  L+PYIEP+ +Y+DP R  +M  +G++++E+ DSL N K+N V ATYLLLD+  +   E   K   G+    +  N S   H    +  +   A   R    + S +     GD  S   D
Sbjct:   30 CRNSVATTTSDEQPHIGQYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDAEMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGSLEQQIMRDRWMNVGYEEEELKPYIEPQPDYKDPRRTDVMLQMGYSQEEIKDSLVNQKYNEVMATYLLLDYKNSELEEGCIKPRPGSDASTI--NASSPSHKVQRSVSSNQKAQSRRPTDQVSSYSKRGGPGDSRSAAED 426

HSP 2 Score: 53.5286 bits (127), Expect = 1.195e-6
Identity = 32/105 (30.48%), Postives = 56/105 (53.33%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P  ++ E+ K L +S+  D+ + E+   +++ C     +    +  + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  689 KPRSLRFTWSMKTTSSMEPAEMMREIRKVL-DSNNCDYDERER---YMLLC-----TSSDPHNFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 784

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark2b (microtubule affinity regulating kinase 2 [Source:NCBI gene;Acc:101172533])

HSP 1 Score: 525.398 bits (1352), Expect = 3.413e-173
Identity = 246/399 (61.65%), Postives = 305/399 (76.44%), Query Frame = 1

Query:  136 AENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTL-LDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNIND 1329
              N+  +   +EQPHIG+Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+++ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  ++ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L   +M+D+W+N G+E+  L+PYIEP+ +Y+DP R  +M  +G++++E+ DSL N K+N V ATYLLLD+  +   E   K   G+    +  N S   H    +  +   A   R    + S +     GD  S   D
Sbjct:   30 CRNSVATTTSDEQPHIGQYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDAEMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGSLEQQIMRDRWMNVGYEEEELKPYIEPQPDYKDPRRTDVMLQMGYSQEEIKDSLVNQKYNEVMATYLLLDYKNSELEEGCIKPRPGSDASTI--NASSPSHKVQRSVSSNQKAQSRRPTDQVSSYSKRGGPGDSRSAAED 426

HSP 2 Score: 53.5286 bits (127), Expect = 1.071e-6
Identity = 32/105 (30.48%), Postives = 56/105 (53.33%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P  ++ E+ K L +S+  D+ + E+   +++ C     +    +  + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  692 KPRSLRFTWSMKTTSSMEPAEMMREIRKVL-DSNNCDYDERER---YMLLC-----TSSDPHNFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 787

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: mark2b (microtubule affinity regulating kinase 2 [Source:NCBI gene;Acc:101172533])

HSP 1 Score: 525.398 bits (1352), Expect = 4.023e-173
Identity = 246/399 (61.65%), Postives = 305/399 (76.44%), Query Frame = 1

Query:  136 AENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTL-LDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNIND 1329
              N+  +   +EQPHIG+Y+L+KTIGKGNFAKVKLA+HV TGK+VAVK+IDKT LN+SSLQKLFREVRIMK ++HPNIVKLFEVIE+++ +YLVMEYAS GEVFDYLV +GRMKEK+AR +FR+IVSA+QYCH K IVHRDLKAENLLL  ++ IKIADFGF+N F +  +LDTFCGSPPYAAPELFQG+KY+GPEVDVWSLGVILYTLVSGSLPFDG N++ELRERVLRGKYRIPFYM+TDCE LLKK LI+NP KR +L   +M+D+W+N G+E+  L+PYIEP+ +Y+DP R  +M  +G++++E+ DSL N K+N V ATYLLLD+  +   E   K   G+    +  N S   H    +  +   A   R    + S +     GD  S   D
Sbjct:   30 CRNSVATTTSDEQPHIGQYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDAEMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGSLEQQIMRDRWMNVGYEEEELKPYIEPQPDYKDPRRTDVMLQMGYSQEEIKDSLVNQKYNEVMATYLLLDYKNSELEEGCIKPRPGSDASTI--NASSPSHKVQRSVSSNQKAQSRRPTDQVSSYSKRGGPGDSRSAAED 426

HSP 2 Score: 53.5286 bits (127), Expect = 1.212e-6
Identity = 32/105 (30.48%), Postives = 56/105 (53.33%), Query Frame = 1

Query: 2524 KPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKL 2838
            KPR +   +    TS + P  ++ E+ K L +S+  D+ + E+   +++ C     +    +  + WE+EV +LPR S  G+R K+ SG+S  FK I   + N+L
Sbjct:  701 KPRSLRFTWSMKTTSSMEPAEMMREIRKVL-DSNNCDYDERER---YMLLC-----TSSDPHNFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 796

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000057003.1 (SMESG000057003.1)

HSP 1 Score: 1835.46 bits (4753), Expect = 0.000e+0
Identity = 909/928 (97.95%), Postives = 909/928 (97.95%), Query Frame = 1

Query:   94 MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPVSYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLCTNTLSSNDSNILLASSDENEQALHLNPDXXXXXXXXXXXXXXXXXEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKTPAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 2877
            MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQP SYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKL                  ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKTPAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN
Sbjct:    1 MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPASYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLY-----------------ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKTPAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 911

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000057003.1 (SMESG000057003.1)

HSP 1 Score: 1811.19 bits (4690), Expect = 0.000e+0
Identity = 897/916 (97.93%), Postives = 897/916 (97.93%), Query Frame = 1

Query:  130 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPVSYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLCTNTLSSNDSNILLASSDENEQALHLNPDXXXXXXXXXXXXXXXXXEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKTPAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 2877
            MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQP SYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKL                  ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKTPAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN
Sbjct:    1 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPASYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLY-----------------ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKTPAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 899

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000057003.1 (SMESG000057003.1)

HSP 1 Score: 1749.95 bits (4531), Expect = 0.000e+0
Identity = 876/928 (94.40%), Postives = 877/928 (94.50%), Query Frame = 1

Query:   94 MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPVSYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLCTNTLSSNDSNILLASSDENEQALHLNPDXXXXXXXXXXXXXXXXXEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKTPAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 2877
            MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQP SYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKL                  ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISS                                +KLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN
Sbjct:    1 MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPASYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLY-----------------ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISS--------------------------------NKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 879

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000057003.1 (SMESG000057003.1)

HSP 1 Score: 1725.68 bits (4468), Expect = 0.000e+0
Identity = 864/916 (94.32%), Postives = 865/916 (94.43%), Query Frame = 1

Query:  130 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPVSYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLCTNTLSSNDSNILLASSDENEQALHLNPDXXXXXXXXXXXXXXXXXEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKTPAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 2877
            MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQP SYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKL                  ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISS                                +KLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN
Sbjct:    1 MNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPASYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLY-----------------ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISS--------------------------------NKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 867

[Close]

BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000057003.1 (SMESG000057003.1)

HSP 1 Score: 1713.74 bits (4437), Expect = 0.000e+0
Identity = 862/928 (92.89%), Postives = 863/928 (93.00%), Query Frame = 1

Query:   94 MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPVSYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLCTNTLSSNDSNILLASSDENEQALHLNPDXXXXXXXXXXXXXXXXXEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKTPAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 2877
            MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDS              DHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQP SYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKL                  ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISS                                +KLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN
Sbjct:    1 MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLAQHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIESERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQIVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPELFQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIPFYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPKKNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLENSSKSDS--------------DHTKHATSKAANDASVTRSGSALESKTNSKVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMGTTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNNGDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVTPATVPLPMDQPASYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTKTDSNCDMANKTTERPNATGDKLY-----------------ENEQALHLNPDKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISS--------------------------------NKLIRRLTSQNPSSNKNKQTVNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAHQNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAKMEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGSSTRFKAIHKILINKLSPVLCTNSAVANN 865

The following BLAST results are available for this feature:

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MARK2	1.370e-174	71.47	microtubule affinity regulating kinase 2 [Source:H...	[more]
MARK2	1.678e-174	71.47	microtubule affinity regulating kinase 2 [Source:H...	[more]
MARK2	2.400e-174	71.47	microtubule affinity regulating kinase 2 [Source:H...	[more]
MARK2	5.230e-174	71.60	microtubule affinity regulating kinase 2 [Source:H...	[more]
MARK2	5.975e-174	71.47	microtubule affinity regulating kinase 2 [Source:H...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
par-1	3.266e-160	67.17	Serine/threonine-protein kinase par-1 [Source:Uni...	[more]
par-1	3.266e-160	67.17	Serine/threonine-protein kinase par-1 [Source:Uni...	[more]
par-1	3.266e-160	67.17	Serine/threonine-protein kinase par-1 [Source:Uni...	[more]
par-1	3.266e-160	67.17	Serine/threonine-protein kinase par-1 [Source:Uni...	[more]
par-1	3.266e-160	67.17	Serine/threonine-protein kinase par-1 [Source:Uni...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
par-1	2.320e-168	70.00	gene:FBgn0260934 transcript:FBtr0301505	[more]
par-1	4.071e-168	70.00	gene:FBgn0260934 transcript:FBtr0330243	[more]
par-1	6.491e-168	70.00	gene:FBgn0260934 transcript:FBtr0100390	[more]
par-1	6.460e-166	70.00	gene:FBgn0260934 transcript:FBtr0086450	[more]
par-1	1.465e-165	67.05	gene:FBgn0260934 transcript:FBtr0301504	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mark2a	6.201e-176	67.39	MAP/microtubule affinity-regulating kinase 2a [Sou...	[more]
mark2a	8.771e-176	67.39	MAP/microtubule affinity-regulating kinase 2a [Sou...	[more]
mark2b	1.591e-174	70.38	MAP/microtubule affinity-regulating kinase 2b [Sou...	[more]
mark2b	2.690e-174	70.38	MAP/microtubule affinity-regulating kinase 2b [Sou...	[more]
mark2b	5.261e-174	70.38	MAP/microtubule affinity-regulating kinase 2b [Sou...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mark2	8.314e-175	59.17	microtubule affinity regulating kinase 2 [Source:N...	[more]
mark2	8.895e-175	59.17	microtubule affinity regulating kinase 2 [Source:N...	[more]
mark2	1.169e-174	59.17	microtubule affinity regulating kinase 2 [Source:N...	[more]
MARK3	1.661e-169	50.99	microtubule affinity regulating kinase 3 [Source:N...	[more]
MARK3	2.031e-169	50.99	microtubule affinity regulating kinase 3 [Source:N...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Mark2	4.542e-175	71.47	MAP/microtubule affinity regulating kinase 2 [Sour...	[more]
Mark2	7.313e-175	71.47	MAP/microtubule affinity regulating kinase 2 [Sour...	[more]
Mark2	8.827e-175	71.47	MAP/microtubule affinity regulating kinase 2 [Sour...	[more]
Mark2	1.028e-174	71.47	MAP/microtubule affinity regulating kinase 2 [Sour...	[more]
Mark2	2.053e-174	71.47	MAP/microtubule affinity regulating kinase 2 [Sour...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O08679\|MARK2_RAT	4.723e-174	71.47	Serine/threonine-protein kinase MARK2 OS=Rattus no...	[more]
sp\|Q7KZI7\|MARK2_HUMAN	5.302e-173	71.47	Serine/threonine-protein kinase MARK2 OS=Homo sapi...	[more]
sp\|Q05512\|MARK2_MOUSE	2.783e-172	71.17	Serine/threonine-protein kinase MARK2 OS=Mus muscu...	[more]
sp\|Q96L34\|MARK4_HUMAN	3.723e-170	55.02	MAP/microtubule affinity-regulating kinase 4 OS=Ho...	[more]
sp\|Q8CIP4\|MARK4_MOUSE	2.638e-169	54.63	MAP/microtubule affinity-regulating kinase 4 OS=Mu...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A183AFP0	5.362e-177	69.43	Uncharacterized protein OS=Echinostoma caproni OX=...	[more]
A0A060WG75	2.359e-176	55.37	Uncharacterized protein OS=Oncorhynchus mykiss OX=...	[more]
A0A210QE29	5.884e-176	66.31	Serine/threonine-protein kinase MARK2 OS=Mizuhopec...	[more]
A0A484CDQ5	3.292e-175	54.00	Non-specific serine/threonine protein kinase OS=Pe...	[more]
A0A4E0RY34	3.710e-175	65.54	Non-specific serine/threonine protein kinase OS=Fa...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mark2a	8.404e-175	62.20	MAP/microtubule affinity-regulating kinase 2a [Sou...	[more]
mark2a	8.789e-175	62.20	MAP/microtubule affinity-regulating kinase 2a [Sou...	[more]
mark2a	9.163e-175	62.20	MAP/microtubule affinity-regulating kinase 2a [Sou...	[more]
mark2a	9.627e-175	62.20	MAP/microtubule affinity-regulating kinase 2a [Sou...	[more]
mark2a	2.367e-174	62.20	MAP/microtubule affinity-regulating kinase 2a [Sou...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000006410.1	3.278e-166	69.62	pep scaffold:Pmarinus_7.0:GL476370:17405:31068:-1 ...	[more]
MARK3	5.690e-166	68.75	microtubule affinity regulating kinase 3 [Source:H...	[more]
MARK3	7.917e-166	60.68	microtubule affinity regulating kinase 3 [Source:H...	[more]
snrka	1.299e-73	40.50	SNF related kinase a [Source:ZFIN;Acc:ZDB-GENE-040...	[more]
NIM1K	1.147e-66	38.58	NIM1 serine/threonine protein kinase [Source:HGNC ...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
SNF1	4.872e-87	38.64	AMP-activated S/T protein kinase; forms a complex ...	[more]
KIN2	7.577e-68	36.93	Serine/threonine protein kinase involved in regula...	[more]
KIN1	9.797e-66	39.16	Serine/threonine protein kinase involved in regula...	[more]
KCC4	8.242e-64	44.49	Protein kinase of the bud neck involved in the sep...	[more]
HSL1	1.804e-62	38.49	Nim1p-related protein kinase; septin-binding kinas...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO30768	1.270e-165	69.30	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO46035	1.793e-116	54.55	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31932	7.183e-96	45.83	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36587	1.672e-75	41.82	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36169	1.805e-75	41.01	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mark2b	1.344e-173	61.65	microtubule affinity regulating kinase 2 [Source:N...	[more]
mark2b	2.225e-173	61.65	microtubule affinity regulating kinase 2 [Source:N...	[more]
mark2b	3.288e-173	61.65	microtubule affinity regulating kinase 2 [Source:N...	[more]
mark2b	3.413e-173	61.65	microtubule affinity regulating kinase 2 [Source:N...	[more]
mark2b	4.023e-173	61.65	microtubule affinity regulating kinase 2 [Source:N...	[more]

BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000057003.1	0.000e+0	97.95	SMESG000057003.1	[more]
SMESG000057003.1	0.000e+0	97.93	SMESG000057003.1	[more]
SMESG000057003.1	0.000e+0	94.40	SMESG000057003.1	[more]
SMESG000057003.1	0.000e+0	94.32	SMESG000057003.1	[more]
SMESG000057003.1	0.000e+0	92.89	SMESG000057003.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30009181 ID=SMED30009181|Name=Non-specific serine/threonine protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2946bp
GTTTATTGCTATTGGCATCTGTTTAAACTGATAAACATATTAATGAAAAA
GTGAATTATATAAATGCATTTTTTTTAATTTATTAAAGATAATATGATTT
CCACAGAAAAAATTGAACTTATTAATGATATGAATGCTGAAAATGCAGCA
AAAAGTAATAAATGGAACGAACAACCTCATATTGGTAAATATAAATTAAT
TAAAACCATCGGAAAAGGAAATTTCGCGAAAGTTAAGTTGGCTCAACATG
TAACGACTGGGAAAAAAGTAGCAGTTAAGGTAATTGACAAAACTGCGCTT
AATAATTCTAGTCTTCAAAAGCTATTTCGCGAAGTTAGAATTATGAAAAC
TATTGATCATCCTAATATTGTAAAGCTATTCGAAGTGATCGAATCAGAAA
GACATGTATATCTGGTAATGGAATATGCCAGTCGAGGGGAAGTTTTTGAT
TATCTCGTCCAAAATGGGCGAATGAAAGAAAAAGACGCCCGACTCAGATT
TCGAGAAATCGTGTCAGCCATTCAGTATTGTCACCATAAGCAAATCGTTC
ACAGAGACCTGAAAGCGGAAAACCTTTTATTAAGTAACGATTTACAAATA
AAAATTGCCGATTTCGGTTTTGCCAATAATTTCGACGTTAAAAAACAATT
GGATACATTTTGTGGCAGCCCACCATATGCGGCTCCGGAACTATTTCAAG
GCAGAAAATACGAGGGGCCAGAAGTCGATGTTTGGTCGTTGGGAGTAATT
CTCTACACTTTAGTCAGCGGATCATTGCCCTTTGATGGCCACAATATGCG
AGAACTTCGAGAACGTGTTTTGCGTGGAAAATATCGAATACCATTTTACA
TGACTACGGATTGTGAGACTTTATTAAAAAAAATGTTGATTGTTAATCCA
ATGAAACGCTTTACGTTGCTAGATGTTATGAAGGATAAATGGATTAATAC
TGGTTTCGAAGATAATCTTTTGCAACCGTATATAGAACCAAAAAAAAATT
ACGAAGATCCTGTTAGATTATCAATAATGAAATCTCTGGGGTTTACTAAG
GATGAAGTATTAGATTCTCTCTACAATGCCAAATTTAACAATGTTACCGC
TACATATTTACTATTAGATCATGATGTAAATAATACTCTCGAAAATAGTT
CGAAATCAGATAGTGGTAATTCATTAAAAAATGTTAGTAATAATTTATCA
CAAAAAGATCATACTAAGCATGCCACGTCCAAAGCAGCCAATGATGCATC
TGTTACAAGATCTGGCAGTGCTTTGGAATCTAAAACCAATAGTAAAGTAA
ATGGTGATAAAGATTCTAATATAAATGATAAAAATCAACATTCGACACAT
AATGAATGTGAATCAAATACTGTGCAGGAATCGTTTAAAAGTAAATTATC
TAATAGAAGTCCAAATAGTATTAAGCCCAGTCCCTCGATGGGTACTACTA
CAACTCATTCTAATGATGAAGTACCTCAGTTGCGGCAAGGATCAACTAGA
TCCAAACCGAATGCGATAAGGATACCGGGAATACAGCCGAATATCAATTT
AGTAGCTCAAAAATCCAATGTAGATAAACCAGATATGAACAACGGAGATA
ATTTGGCAGTCCCTGCTAAAACATCGACCTGGGTTAAGCGCAATAACACT
TTTACTTATGCTGATAAAAATACCACATCAGAAGTTGAATCGAAACCTGT
TACACGGACGAAAAATGTGATGAATATGCTTAGTCATGTTACACCCGCTA
CTGTTCCTTTGCCAATGGATCAGCCAGTATCATATTCAAAAAAACATTCT
AATAACGATTCGACTGATAAAACAAGTAAAAAATACGACGGTGGTGCATA
TTCTTCTTATAAAACGTCTCATAATGAAATAGAAACTACAAAAACCGATT
CAAACTGTGATATGGCCAATAAAACTACAGAACGGCCAAATGCCACTGGT
GACAAGCTCTGTACGAATACATTGTCTTCTAATGACAGTAACATTTTACT
TGCTTCGTCAGATGAGAATGAGCAAGCTCTGCATCTAAATCCCGACAAGA
ACACTTCGACATTAAAATCAATCAACAATTCATTGTCTAGCAGTAAAGAA
AAACCTGACATTTATCCTCTTCTTAATAAGCCAAAACAAATTCATACGAA
CAGTCTGTTTCGGTCATTTACAAATAAAATATCCTCAAAAACACCTGCCG
GTCCTGAGTTGAATATTAATGAGACTTTGTCACCTTATGACAATTCAGAA
GTTAGTCAACAATTTCGTCGATACTCCACAGGAGATAAACTCATTCGACG
TTTAACATCCCAAAACCCCTCATCCAATAAAAACAAACAGACAGTTAATG
AAGAATCAGATCACAGCCCAAATACCAATGATCCTTGGACCCCTATGGAT
AATGTTACTTCTCAAAATGAAAAGAGAAAAATCTCTGCTTCATCTGATTT
TACTGGGGATAATCATTCGTCTCTAGATCAAAACAAAGCTCATCAAAACT
ACACATTAAAACCCAATCAAAACAAGCCTCGTGTTATGCATCTGGTGTTT
CGCAAAAGTCTAACTAGCAAATTACGACCTGAAGCAATAATTTCTGAAAT
GATGAAATCTCTTCAAAATTCTGATGAAATTGATTTTGCGAAAATGGAAC
AAATAGATACTTTTGTAATTGAGTGCCAAGGTAAACTGAAATCAGAACAA
GGAGGAAACGAATTGATTCATTGGGAAATTGAAGTCTTCCGCTTGCCGAG
GTCATCTTCATTTGGAATTCGAATAAAAAAACAGTCCGGTAGCTCAACGA
GATTCAAAGCAATTCATAAAATTCTAATAAATAAATTGTCTCCAGTTTTG
TGTACGAACAGCGCTGTAGCTAACAATTAACCAATGATAATAATGAATTA
ATAATATTGCGTATCACAAACGAAACAACACGTCGTCAGTATTTCA

protein sequence of SMED30009181-orf-1

>SMED30009181-orf-1 ID=SMED30009181-orf-1|Name=SMED30009181-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=929bp
MISTEKIELINDMNAENAAKSNKWNEQPHIGKYKLIKTIGKGNFAKVKLA
QHVTTGKKVAVKVIDKTALNNSSLQKLFREVRIMKTIDHPNIVKLFEVIE
SERHVYLVMEYASRGEVFDYLVQNGRMKEKDARLRFREIVSAIQYCHHKQ
IVHRDLKAENLLLSNDLQIKIADFGFANNFDVKKQLDTFCGSPPYAAPEL
FQGRKYEGPEVDVWSLGVILYTLVSGSLPFDGHNMRELRERVLRGKYRIP
FYMTTDCETLLKKMLIVNPMKRFTLLDVMKDKWINTGFEDNLLQPYIEPK
KNYEDPVRLSIMKSLGFTKDEVLDSLYNAKFNNVTATYLLLDHDVNNTLE
NSSKSDSGNSLKNVSNNLSQKDHTKHATSKAANDASVTRSGSALESKTNS
KVNGDKDSNINDKNQHSTHNECESNTVQESFKSKLSNRSPNSIKPSPSMG
TTTTHSNDEVPQLRQGSTRSKPNAIRIPGIQPNINLVAQKSNVDKPDMNN
GDNLAVPAKTSTWVKRNNTFTYADKNTTSEVESKPVTRTKNVMNMLSHVT
PATVPLPMDQPVSYSKKHSNNDSTDKTSKKYDGGAYSSYKTSHNEIETTK
TDSNCDMANKTTERPNATGDKLCTNTLSSNDSNILLASSDENEQALHLNP
DKNTSTLKSINNSLSSSKEKPDIYPLLNKPKQIHTNSLFRSFTNKISSKT
PAGPELNINETLSPYDNSEVSQQFRRYSTGDKLIRRLTSQNPSSNKNKQT
VNEESDHSPNTNDPWTPMDNVTSQNEKRKISASSDFTGDNHSSLDQNKAH
QNYTLKPNQNKPRVMHLVFRKSLTSKLRPEAIISEMMKSLQNSDEIDFAK
MEQIDTFVIECQGKLKSEQGGNELIHWEIEVFRLPRSSSFGIRIKKQSGS
STRFKAIHKILINKLSPVLCTNSAVANN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0000166	nucleotide binding
GO:0016740	transferase activity
GO:0005524	ATP binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0016301	kinase activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte
PLANA:0000099	neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR015940	UBA
IPR000719	Prot_kinase_dom
IPR028375	KA1/Ssp2_C
IPR001772	KA1_dom
IPR008271	Ser/Thr_kinase_AS
IPR017441	Protein_kinase_ATP_BS
IPR011009	Kinase-like_dom_sf

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0000226	microtubule cytoskeleton organization
GO:0016310	phosphorylation
GO:0030010	establishment of cell polarity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR015940	Ubiquitin-associated domain	SMART	SM00165	uba_6	coord: 305..342 e-value: 0.0015 score: 27.8
IPR015940	Ubiquitin-associated domain	PROSITE	PS50030	UBA	coord: 301..343 score: 9.703
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 33..284 e-value: 2.1E-102 score: 356.2
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 33..284 e-value: 1.2E-74 score: 251.0
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 33..284 score: 52.513
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 115..298 e-value: 1.9E-61 score: 208.8
None	No IPR available	GENE3D	G3DSA:3.30.310.80		coord: 809..916 e-value: 1.2E-15 score: 59.4
None	No IPR available	GENE3D	G3DSA:1.10.8.10		coord: 299..343 e-value: 1.9E-16 score: 61.3
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 17..114 e-value: 9.0E-37 score: 127.1
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 380..399
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 369..473
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 420..473
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 555..581
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 735..809
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 400..419
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 735..811
None	No IPR available	PANTHER	PTHR24346	MAP/MICROTUBULE AFFINITY-REGULATING KINASE	coord: 25..873
None	No IPR available	PANTHER	PTHR24346:SF28	MAP/MICROTUBULE AFFINITY-REGULATING KINASE 4	coord: 25..873
None	No IPR available	CDD	cd12121	MARK_C_like	coord: 819..915 e-value: 7.12699E-16 score: 71.8714
None	No IPR available	CDD	cd14337	UBA_MARK_Par1	coord: 305..343 e-value: 3.4636E-14 score: 65.2316
IPR001772	Kinase associated domain 1 (KA1)	PFAM	PF02149	KA1	coord: 875..915 e-value: 3.2E-6 score: 26.8
IPR001772	Kinase associated domain 1 (KA1)	PROSITE	PS50032	KA1	coord: 868..917 score: 12.008
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 151..163
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 39..62
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 30..304
IPR028375	KA1 domain/Ssp2, C-terminal	SUPERFAMILY	SSF103243	KA1-like	coord: 805..916