Mushroom body large-type Kenyon-related protein

Overview


Name	Mushroom body large-type Kenyon-related protein
Smed ID	SMED30009090
Length (bp)	1840

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Mushroom body large-type Kenyon-related protein (SMED30009090) t-SNE clustered cells

Violin plots show distribution of expression levels for Mushroom body large-type Kenyon-related protein (SMED30009090) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mushroom body large-type Kenyon-related protein (SMED30009090) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30009090

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 14

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30009090	h1SMcG0011677	SmedASXL_010435	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
Smed sexual biotype	SMED30009090	h1SMcG0011677	Contig36855	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30009090	h1SMcG0011677	Contig36855	newmark_ests	PMID:29674431 Fincher et al., 2018
pharynx	SMED30009090	h1SMcG0011677	dd_Smed_v4_17498_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30009090	h1SMcG0011677	dd_Smed_v4_17498_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30009090	h1SMcG0011677	dd_Smed_v4_17498_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30009090	h1SMcG0011677	dd_Smed_v4_17498_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30009090	h1SMcG0011677	dd_Smed_v4_17498_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30009090	h1SMcG0011677	dd_Smed_v6_17498_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
neuron	SMED30009090	h1SMcG0011677	Contig45195	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016
neuron	SMED30009090	h1SMcG0011677	Contig45195	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
lateral branch	SMED30009090	h1SMcG0011677	Contig45195	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016
lateral branch	SMED30009090	h1SMcG0011677	Contig45195	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
head region	SMED30009090	h1SMcG0011677	OX_Smed_1.0.11085	ox_Smed_v2	PMID:24238224 Kao et al., 2013

Note: Hover over icons to view figure legend

Homology

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BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Human
Match: LCOR (ligand dependent nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29503])

HSP 1 Score: 70.0922 bits (170), Expect = 4.168e-12
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  340 RKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKE 388

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Human
Match: LCOR (ligand dependent nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29503])

HSP 1 Score: 70.0922 bits (170), Expect = 4.481e-12
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  340 RKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKE 388

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Human
Match: LCOR (ligand dependent nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29503])

HSP 1 Score: 70.0922 bits (170), Expect = 4.481e-12
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  340 RKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKE 388

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Human
Match: LCOR (ligand dependent nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29503])

HSP 1 Score: 70.0922 bits (170), Expect = 4.481e-12
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  340 RKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKE 388

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Human
Match: LCORL (ligand dependent nuclear receptor corepressor like [Source:HGNC Symbol;Acc:HGNC:30776])

HSP 1 Score: 65.855 bits (159), Expect = 1.180e-10
Identity = 30/54 (55.56%), Postives = 39/54 (72.22%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGL 1551
             KKRG YRQY+ E++ +AI  V  G+MSV KA   +GVPHSTLEY+VK+ +  L
Sbjct:  432 RKKRGRYRQYDHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLEYKVKERSGTL 485

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BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Celegans
Match: mbr-1 (Mblk-1-related factor 1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGQ5])

HSP 1 Score: 71.2478 bits (173), Expect = 6.678e-13
Identity = 29/47 (61.70%), Postives = 40/47 (85.11%), Query Frame = 1

Query: 1396 KRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            KRG YR+Y+   L++A+ +VR GEM+VH+AG+ FGVPHSTLEY+VK+
Sbjct:  336 KRGQYRKYDKNALDEAVRSVRRGEMTVHRAGSFFGVPHSTLEYKVKE 382

HSP 2 Score: 55.0694 bits (131), Expect = 1.018e-7
Identity = 31/78 (39.74%), Postives = 45/78 (57.69%), Query Frame = 1

Query:  316 EHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKV 549
            E V+  +P+D SL+               K  I   +Y+  +L  AV  I  G++GTRRA+ +YGIPRSTLRN+I+K+
Sbjct:  132 ESVAPEKPVDESLN---------------KSNILRRNYTVEDLTQAVEDIRQGKLGTRRASVVYGIPRSTLRNKIYKL 194

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Fly
Match: Eip93F (gene:FBgn0264490 transcript:FBtr0112874)

HSP 1 Score: 69.707 bits (169), Expect = 5.100e-12
Identity = 29/47 (61.70%), Postives = 40/47 (85.11%), Query Frame = 1

Query: 1396 KRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            KRG YR Y+ + L +A+ AV+ GEMSVH+AG+++GVPHSTLEY+VK+
Sbjct:  786 KRGKYRNYDRDSLVEAVKAVQRGEMSVHRAGSYYGVPHSTLEYKVKE 832

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Fly
Match: Eip93F (gene:FBgn0264490 transcript:FBtr0084169)

HSP 1 Score: 69.707 bits (169), Expect = 5.113e-12
Identity = 29/47 (61.70%), Postives = 40/47 (85.11%), Query Frame = 1

Query: 1396 KRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            KRG YR Y+ + L +A+ AV+ GEMSVH+AG+++GVPHSTLEY+VK+
Sbjct:  763 KRGKYRNYDRDSLVEAVKAVQRGEMSVHRAGSYYGVPHSTLEYKVKE 809

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Fly
Match: Eip93F (gene:FBgn0264490 transcript:FBtr0330384)

HSP 1 Score: 69.707 bits (169), Expect = 5.463e-12
Identity = 29/47 (61.70%), Postives = 40/47 (85.11%), Query Frame = 1

Query: 1396 KRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            KRG YR Y+ + L +A+ AV+ GEMSVH+AG+++GVPHSTLEY+VK+
Sbjct:  763 KRGKYRNYDRDSLVEAVKAVQRGEMSVHRAGSYYGVPHSTLEYKVKE 809

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Zebrafish
Match: lcor (ligand dependent nuclear receptor corepressor [Source:ZFIN;Acc:ZDB-GENE-061201-6])

HSP 1 Score: 70.8626 bits (172), Expect = 1.761e-12
Identity = 31/49 (63.27%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA N +G+PHSTLEY+VK+
Sbjct:  360 RKKRGRYRQYNSEILEEAIAVVMSGKMSVSKAQNIYGIPHSTLEYKVKE 408

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Zebrafish
Match: CR769781.1 (ligand dependent nuclear receptor corepressor-like [Source:NCBI gene;Acc:558430])

HSP 1 Score: 65.4698 bits (158), Expect = 1.043e-10
Identity = 30/51 (58.82%), Postives = 38/51 (74.51%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMT 1542
             KKRG YRQY+ ++L +AI  V  G+MSV KA   +GVPHSTLEY+VK+ T
Sbjct:  476 RKKRGRYRQYDHDILEEAIAMVIGGKMSVSKAQGVYGVPHSTLEYKVKERT 526

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Zebrafish
Match: lcorl (ligand dependent nuclear receptor corepressor-like [Source:ZFIN;Acc:ZDB-GENE-030131-6300])

HSP 1 Score: 65.4698 bits (158), Expect = 1.053e-10
Identity = 30/51 (58.82%), Postives = 38/51 (74.51%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMT 1542
             KKRG YRQY+ ++L +AI  V  G+MSV KA   +GVPHSTLEY+VK+ T
Sbjct:  482 RKKRGRYRQYDHDILEEAIAMVIGGKMSVSKAQGVYGVPHSTLEYKVKERT 532

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Zebrafish
Match: CR762426.1 (ligand dependent nuclear receptor corepressor-like [Source:NCBI gene;Acc:558430])

HSP 1 Score: 65.4698 bits (158), Expect = 1.071e-10
Identity = 30/51 (58.82%), Postives = 38/51 (74.51%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMT 1542
             KKRG YRQY+ ++L +AI  V  G+MSV KA   +GVPHSTLEY+VK+ T
Sbjct:  476 RKKRGRYRQYDHDILEEAIAMVIGGKMSVSKAQGVYGVPHSTLEYKVKERT 526

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Zebrafish
Match: CR391911.1 (ligand dependent nuclear receptor corepressor-like [Source:NCBI gene;Acc:558430])

HSP 1 Score: 65.4698 bits (158), Expect = 1.168e-10
Identity = 30/51 (58.82%), Postives = 38/51 (74.51%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMT 1542
             KKRG YRQY+ ++L +AI  V  G+MSV KA   +GVPHSTLEY+VK+ T
Sbjct:  488 RKKRGRYRQYDHDILEEAIAMVIGGKMSVSKAQGVYGVPHSTLEYKVKERT 538

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Xenopus
Match: lcor (ligand dependent nuclear receptor corepressor [Source:NCBI gene;Acc:100125102])

HSP 1 Score: 68.5514 bits (166), Expect = 1.886e-11
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  485 RKKRGRYRQYNSEILEEAIAVVMNGKMSVSKAQSIYGIPHSTLEYKVKE 533

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Xenopus
Match: trmt5 (tRNA methyltransferase 5 [Source:Xenbase;Acc:XB-GENE-957548])

HSP 1 Score: 61.2326 bits (147), Expect = 3.405e-9
Identity = 28/51 (54.90%), Postives = 37/51 (72.55%), Query Frame = 1

Query: 1399 RGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGL 1551
            RG YRQY+ E++ +AI  V  G+MSV KA   +GVPHSTLEY+VK+ +  L
Sbjct:  493 RGRYRQYDHEIMEEAIAMVLGGKMSVSKAQGIYGVPHSTLEYKVKERSGTL 543

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Mouse
Match: Lcor (ligand dependent nuclear receptor corepressor [Source:MGI Symbol;Acc:MGI:2443930])

HSP 1 Score: 69.707 bits (169), Expect = 3.003e-12
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  340 RKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKE 388

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Mouse
Match: Lcor (ligand dependent nuclear receptor corepressor [Source:MGI Symbol;Acc:MGI:2443930])

HSP 1 Score: 70.0922 bits (170), Expect = 3.132e-12
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  340 RKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKE 388

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Mouse
Match: Lcor (ligand dependent nuclear receptor corepressor [Source:MGI Symbol;Acc:MGI:2443930])

HSP 1 Score: 70.0922 bits (170), Expect = 3.132e-12
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  340 RKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKE 388

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Mouse
Match: Lcorl (ligand dependent nuclear receptor corepressor-like [Source:MGI Symbol;Acc:MGI:2651932])

HSP 1 Score: 65.855 bits (159), Expect = 9.053e-11
Identity = 30/54 (55.56%), Postives = 39/54 (72.22%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGL 1551
             KKRG YRQY+ E++ +AI  V  G+MSV KA   +GVPHSTLEY+VK+ +  L
Sbjct:  432 RKKRGRYRQYDHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLEYKVKERSGTL 485

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Mouse
Match: Lcorl (ligand dependent nuclear receptor corepressor-like [Source:MGI Symbol;Acc:MGI:2651932])

HSP 1 Score: 65.0846 bits (157), Expect = 1.494e-10
Identity = 30/54 (55.56%), Postives = 39/54 (72.22%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGL 1551
             KKRG YRQY+ E++ +AI  V  G+MSV KA   +GVPHSTLEY+VK+ +  L
Sbjct:  515 RKKRGRYRQYDHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLEYKVKERSGTL 568

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. UniProt/SwissProt
Match: sp|G5EGQ5|MBR1_CAEEL (Mblk-1-related factor 1 OS=Caenorhabditis elegans OX=6239 GN=mbr-1 PE=2 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 8.495e-12
Identity = 29/47 (61.70%), Postives = 40/47 (85.11%), Query Frame = 1

Query: 1396 KRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            KRG YR+Y+   L++A+ +VR GEM+VH+AG+ FGVPHSTLEY+VK+
Sbjct:  336 KRGQYRKYDKNALDEAVRSVRRGEMTVHRAGSFFGVPHSTLEYKVKE 382

HSP 2 Score: 55.0694 bits (131), Expect = 1.294e-6
Identity = 31/78 (39.74%), Postives = 45/78 (57.69%), Query Frame = 1

Query:  316 EHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKV 549
            E V+  +P+D SL+               K  I   +Y+  +L  AV  I  G++GTRRA+ +YGIPRSTLRN+I+K+
Sbjct:  132 ESVAPEKPVDESLN---------------KSNILRRNYTVEDLTQAVEDIRQGKLGTRRASVVYGIPRSTLRNKIYKL 194

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. UniProt/SwissProt
Match: sp|Q96JN0|LCOR_HUMAN (Ligand-dependent corepressor OS=Homo sapiens OX=9606 GN=LCOR PE=1 SV=2)

HSP 1 Score: 70.0922 bits (170), Expect = 2.152e-11
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  340 RKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKE 388

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. UniProt/SwissProt
Match: sp|Q6ZPI3|LCOR_MOUSE (Ligand-dependent corepressor OS=Mus musculus OX=10090 GN=Lcor PE=2 SV=2)

HSP 1 Score: 70.0922 bits (170), Expect = 2.191e-11
Identity = 30/49 (61.22%), Postives = 39/49 (79.59%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQYN+E+L +AI  V  G+MSV KA + +G+PHSTLEY+VK+
Sbjct:  340 RKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKE 388

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. UniProt/SwissProt
Match: sp|Q95YM8|MBLK1_APIME (Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera OX=7460 GN=Mblk-1 PE=1 SV=1)

HSP 1 Score: 68.9366 bits (167), Expect = 9.612e-11
Identity = 29/47 (61.70%), Postives = 40/47 (85.11%), Query Frame = 1

Query: 1396 KRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            KRG YR Y+ + L +A+ AV+ GEMSVH+AG+++GVPHSTLEY+VK+
Sbjct: 1036 KRGKYRNYDRDSLVEAVRAVQRGEMSVHRAGSYYGVPHSTLEYKVKE 1082

HSP 2 Score: 61.2326 bits (147), Expect = 2.377e-8
Identity = 25/42 (59.52%), Postives = 36/42 (85.71%), Query Frame = 1

Query:  424 SYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKV 549
            +Y+E EL +A+R I  G++GTRRAA +YGIPRSTLRN+++K+
Sbjct:  590 AYTEEELQAALRDIQSGKLGTRRAAVIYGIPRSTLRNKVYKL 631

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. UniProt/SwissProt
Match: sp|Q8N3X6|LCORL_HUMAN (Ligand-dependent nuclear receptor corepressor-like protein OS=Homo sapiens OX=9606 GN=LCORL PE=1 SV=4)

HSP 1 Score: 65.4698 bits (158), Expect = 8.734e-10
Identity = 30/54 (55.56%), Postives = 39/54 (72.22%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGL 1551
             KKRG YRQY+ E++ +AI  V  G+MSV KA   +GVPHSTLEY+VK+ +  L
Sbjct:  516 RKKRGRYRQYDHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLEYKVKERSGTL 569

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. TrEMBL
Match: A0A1Z1R179 (Mushroom body large-type Kenyon-related protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 979.163 bits (2530), Expect = 0.000e+0
Identity = 535/538 (99.44%), Postives = 537/538 (99.81%), Query Frame = 1

Query:   79 MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKPIKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDTDQRMSMVDFFKKILKDDSMFTNLFHQKYQRXXXXXXXXXXXXXXXXXXVHFRQKENHVSNKELFKNELNEIIKHQQKKDSSRIQEIQLSDSFLDYNKPDFPXXXXXXXXXXPDLLTSYFQQDHQTNIMSSYLFMMCQQNLLSSVYSSLMMPDWQLPNFNFGNIPSPHNLYSTKKSXXXXXXXXXXXXXXXKDQADKHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDNKPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQTHXXXXXXXXXXXXXXDGESKKTDSDGCNTNVSLNSQI 1692
            MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKPIKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDTDQRMSMVDFFKKILKDDSMFTNLFHQKYQRENKEEKKKTVITEKENNKVHFRQKENHVSNKELFKNELNEIIKHQQKKDSSRIQEIQLSDSFLDYNKPDFPINQININSNIPD LTSYFQQDHQTNIMSSYLFMMCQQNLLSSVYSSLMMPDWQLPNFNFG+IPSPHNLYSTKKSEIINNKENHLENINNKDQA+KHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDNKPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQTHKRKKSNSLENSKSNDGESKKTDSDGCNTNVSLNSQI
Sbjct:    1 MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKPIKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDTDQRMSMVDFFKKILKDDSMFTNLFHQKYQRENKEEKKKTVITEKENNKVHFRQKENHVSNKELFKNELNEIIKHQQKKDSSRIQEIQLSDSFLDYNKPDFPINQININSNIPDSLTSYFQQDHQTNIMSSYLFMMCQQNLLSSVYSSLMMPDWQLPNFNFGDIPSPHNLYSTKKSEIINNKENHLENINNKDQAEKHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDNKPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQTHKRKKSNSLENSKSNDGESKKTDSDGCNTNVSLNSQI 538

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. TrEMBL
Match: A0A1S3JRV9 (ligand-dependent nuclear receptor corepressor-like protein isoform X3 OS=Lingula unguis OX=7574 GN=LOC106175323 PE=4 SV=1)

HSP 1 Score: 90.5077 bits (223), Expect = 3.048e-15
Identity = 64/194 (32.99%), Postives = 94/194 (48.45%), Query Frame = 1

Query:   91 KCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDED-KP---IKTTVIKDWNEEEIYCLCEKKIS---------------EINNSHEHVSQ--SEPLDLSLSS-----PTSINE---------------KIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKV 549
            +C  ER+  + +L +W  KIP+ VG+E I K     S D +D+  +P   ++   +KDW  E     C  ++                  N + E + Q  ++PLDLS +S     P    E               +I   + RK      +Y+E EL +AV  I  G++GTRRAA+LYGIPRSTLRN+IFK+
Sbjct:    8 RCAQERRAFKKDLLSWTKKIPLAVGLETIAKEF--ASKDVMDKLLEPFNNLEPDTVKDWEPETTCHFCFSRLKFMIETVENGSSTEDESCNRTREDIEQEDNQPLDLSATSQAAKSPGKYTEESAAVTKPPVELKVPQIKVNTSRKKDTGRRTYTEEELSAAVDDIRSGKLGTRRAASLYGIPRSTLRNKIFKL 199

HSP 2 Score: 76.2554 bits (186), Expect = 1.071e-10
Identity = 31/47 (65.96%), Postives = 43/47 (91.49%), Query Frame = 1

Query: 1396 KRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            KRG YR+YN+++L +A+ AV+ GEMSVH+AG++FGVPHSTLEY+VK+
Sbjct:  432 KRGQYRKYNSQLLMEAVRAVQRGEMSVHRAGSYFGVPHSTLEYKVKE 478

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. TrEMBL
Match: A0A1I8BYX5 (Uncharacterized protein OS=Meloidogyne hapla OX=6305 PE=4 SV=1)

HSP 1 Score: 83.9593 bits (206), Expect = 3.660e-13
Identity = 35/51 (68.63%), Postives = 44/51 (86.27%), Query Frame = 1

Query: 1384 SRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             + +KRG YR+YN E L+KA+ AVR GEMSVH+AG+HFGVPHSTLEY+VK+
Sbjct:  416 GKRQKRGQYRKYNKEALDKAVTAVRNGEMSVHRAGSHFGVPHSTLEYKVKE 466

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. TrEMBL
Match: A0A0R3W630 (HTH psq-type domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS5624 PE=4 SV=1)

HSP 1 Score: 82.4185 bits (202), Expect = 3.853e-13
Identity = 41/89 (46.07%), Postives = 61/89 (68.54%), Query Frame = 1

Query:  400 RKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDT---DQRMSMVDFFKKILKDDSMFTNLFHQK 657
            R  V +N  Y+  EL SAVRAIC G++GTRRAA++YGIPRSTLRN+I K+ + +K  +T    + +S+ DFF +    + + ++ FH+K
Sbjct:  196 RCAVEANGPYTASELASAVRAICSGQLGTRRAASMYGIPRSTLRNKICKLNEIRKHEETMRGGKPISLSDFFHQFTSSEKLPSDPFHRK 284

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. TrEMBL
Match: A0A0V1BHW2 (Mushroom body large-type Kenyon cell-specific protein 1 OS=Trichinella spiralis OX=6334 GN=Mblk-1 PE=4 SV=1)

HSP 1 Score: 82.0333 bits (201), Expect = 1.854e-12
Identity = 47/118 (39.83%), Postives = 66/118 (55.93%), Query Frame = 1

Query: 1225 LGEINISSEICKNDQS-------------DNKPEESIE-ESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            LG I + +E+C N  S             D++P+ + E  SD + S  S   N+       DE +     +KRG YR+Y+   L  A+ +VR GEMSVHKAG+ +GVPHSTLEY+VK+
Sbjct:  455 LGLIGLDAELCTNTDSRAAGNVADRSSIVDSRPQMTAEASSDGAGSRSSSDANQL------DEANAKKLRRKRGQYRKYDKNALALAVQSVRRGEMSVHKAGSFYGVPHSTLEYKVKE 566

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Cavefish
Match: lcor (ligand dependent nuclear receptor corepressor [Source:ZFIN;Acc:ZDB-GENE-061201-6])

HSP 1 Score: 72.7886 bits (177), Expect = 3.161e-13
Identity = 33/58 (56.90%), Postives = 41/58 (70.69%), Query Frame = 1

Query: 1363 SDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            +D        KKRG YRQYNTE+L +AI  V  G+MSV KA N +G+PHSTLEY+VK+
Sbjct:  337 ADPTGSKQPRKKRGRYRQYNTEILEEAIAVVMGGKMSVSKAQNIYGIPHSTLEYKVKE 394

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Cavefish
Match: lcor (ligand dependent nuclear receptor corepressor [Source:ZFIN;Acc:ZDB-GENE-061201-6])

HSP 1 Score: 72.7886 bits (177), Expect = 3.867e-13
Identity = 33/58 (56.90%), Postives = 41/58 (70.69%), Query Frame = 1

Query: 1363 SDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            +D        KKRG YRQYNTE+L +AI  V  G+MSV KA N +G+PHSTLEY+VK+
Sbjct:  355 ADPTGSKQPRKKRGRYRQYNTEILEEAIAVVMGGKMSVSKAQNIYGIPHSTLEYKVKE 412

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Cavefish
Match: LCORL (ligand dependent nuclear receptor corepressor like [Source:NCBI gene;Acc:103045877])

HSP 1 Score: 64.6994 bits (156), Expect = 1.584e-10
Identity = 29/49 (59.18%), Postives = 37/49 (75.51%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             KKRG YRQY+ ++L +AI  V  G+MSV KA   +GVPHSTLEY+VK+
Sbjct:  488 RKKRGRYRQYDHDILEEAIAMVMGGKMSVSKAQGVYGVPHSTLEYKVKE 536

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003404.1 (pep scaffold:Pmarinus_7.0:GL476560:346958:365324:1 gene:ENSPMAG00000003112.1 transcript:ENSPMAT00000003404.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.1586 bits (152), Expect = 9.728e-11
Identity = 27/49 (55.10%), Postives = 36/49 (73.47%), Query Frame = 1

Query: 1390 HKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
             +KRG YRQY++ +L +AI  V  G MSV KA   +G+PHSTLEY+VK+
Sbjct:  515 RRKRGRYRQYDSGILEEAISMVMSGRMSVSKAQALYGIPHSTLEYKVKE 563

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Medaka
Match: lcor (ligand dependent nuclear receptor corepressor [Source:NCBI gene;Acc:105356745])

HSP 1 Score: 73.1738 bits (178), Expect = 3.057e-13
Identity = 37/77 (48.05%), Postives = 51/77 (66.23%), Query Frame = 1

Query: 1306 DTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            D S S P+     ++I+ +  + S     KKRG YRQYN+E+L +AI  V  G+MSV KA N +G+PHSTLEY+VK+
Sbjct:  406 DHSSSGPA-----YSISDVEGDPSSKQPRKKRGRYRQYNSEILEEAIAVVMSGKMSVSKAQNMYGIPHSTLEYKVKE 477

[Close]

Query: 1306 DTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            D S S P+     ++I+ +  + S     KKRG YRQYN+E+L +AI  V  G+MSV KA N +G+PHSTLEY+VK+
Sbjct:  406 DHSSSGPA-----YSISDVEGDPSSKQPRKKRGRYRQYNSEILEEAIAVVMSGKMSVSKAQNMYGIPHSTLEYKVKE 477

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Medaka
Match: lcor (ligand dependent nuclear receptor corepressor [Source:NCBI gene;Acc:105356745])

HSP 1 Score: 73.1738 bits (178), Expect = 4.511e-13
Identity = 37/77 (48.05%), Postives = 51/77 (66.23%), Query Frame = 1

Query: 1306 DTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            D S S P+     ++I+ +  + S     KKRG YRQYN+E+L +AI  V  G+MSV KA N +G+PHSTLEY+VK+
Sbjct:  526 DHSSSGPA-----YSISDVEGDPSSKQPRKKRGRYRQYNSEILEEAIAVVMSGKMSVSKAQNMYGIPHSTLEYKVKE 597

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Medaka
Match: lcor (ligand dependent nuclear receptor corepressor [Source:NCBI gene;Acc:105356745])

HSP 1 Score: 72.7886 bits (177), Expect = 5.265e-13
Identity = 37/77 (48.05%), Postives = 51/77 (66.23%), Query Frame = 1

Query: 1306 DTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQ 1536
            D S S P+     ++I+ +  + S     KKRG YRQYN+E+L +AI  V  G+MSV KA N +G+PHSTLEY+VK+
Sbjct:  548 DHSSSGPA-----YSISDVEGDPSSKQPRKKRGRYRQYNSEILEEAIAVVMSGKMSVSKAQNMYGIPHSTLEYKVKE 619

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Planmine SMEST
Match: SMESG000070784.1 (SMESG000070784.1)

HSP 1 Score: 982.63 bits (2539), Expect = 0.000e+0
Identity = 536/538 (99.63%), Postives = 538/538 (100.00%), Query Frame = 1

Query:   79 MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKPIKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDTDQRMSMVDFFKKILKDDSMFTNLFHQKYQRXXXXXXXXXXXXXXXXXXVHFRQKENHVSNKELFKNELNEIIKHQQKKDSSRIQEIQLSDSFLDYNKPDFPXXXXXXXXXXPDLLTSYFQQDHQTNIMSSYLFMMCQQNLLSSVYSSLMMPDWQLPNFNFGNIPSPHNLYSTKKSXXXXXXXXXXXXXXXKDQADKHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDNKPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQTHXXXXXXXXXXXXXXDGESKKTDSDGCNTNVSLNSQI 1692
            MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKPIKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDTDQRMSMVDFFKKILKDDSMFTNLFHQKYQRENKEEKKKTVITEKENNKVHFRQKENHVSNKELFKNELNEIIKHQQ+KDSSRIQEIQLSDSFLDYNKPDFPINQININSNIPDLLTSYFQQDHQTNIMSSYLFMMCQQNLLSSVYSSLMMPDWQLPNFNFGNIPSPHNLYSTKKSEIINNKENHLENINNKDQA+KHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDNKPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQTHKRKKSNSLENSKSNDGESKKTDSDGCNTNVSLNSQI
Sbjct:    1 MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKPIKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDTDQRMSMVDFFKKILKDDSMFTNLFHQKYQRENKEEKKKTVITEKENNKVHFRQKENHVSNKELFKNELNEIIKHQQQKDSSRIQEIQLSDSFLDYNKPDFPINQININSNIPDLLTSYFQQDHQTNIMSSYLFMMCQQNLLSSVYSSLMMPDWQLPNFNFGNIPSPHNLYSTKKSEIINNKENHLENINNKDQAEKHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDNKPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQTHKRKKSNSLENSKSNDGESKKTDSDGCNTNVSLNSQI 538

[Close]

BLAST of Mushroom body large-type Kenyon-related protein vs. Planmine SMEST
Match: SMESG000070784.1 (SMESG000070784.1)

HSP 1 Score: 931.013 bits (2405), Expect = 0.000e+0
Identity = 517/538 (96.10%), Postives = 519/538 (96.47%), Query Frame = 1

Query:   79 MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKPIKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDTDQRMSMVDFFKKILKDDSMFTNLFHQKYQRXXXXXXXXXXXXXXXXXXVHFRQKENHVSNKELFKNELNEIIKHQQKKDSSRIQEIQLSDSFLDYNKPDFPXXXXXXXXXXPDLLTSYFQQDHQTNIMSSYLFMMCQQNLLSSVYSSLMMPDWQLPNFNFGNIPSPHNLYSTKKSXXXXXXXXXXXXXXXKDQADKHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDNKPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQTHXXXXXXXXXXXXXXDGESKKTDSDGCNTNVSLNSQI 1692
            MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKPIKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDTDQRMSM                   QKYQRENKEEKKKTVITEKENNKVHFRQKENHVSNKELFKNELNEIIKHQQ+KDSSRIQEIQLSDSFLDYNKPDFPINQININSNIPDLLTSYFQQDHQTNIMSSYLFMMCQQNLLSSVYSSLMMPDWQLPNFNFGNIPSPHNLYSTKKSEIINNKENHLENINNKDQA+KHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDNKPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQTHKRKKSNSLENSKSNDGESKKTDSDGCNTNVSLNSQI
Sbjct:    1 MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKPIKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINEKIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTLRNRIFKVYDAKKIHDTDQRMSM-------------------QKYQRENKEEKKKTVITEKENNKVHFRQKENHVSNKELFKNELNEIIKHQQQKDSSRIQEIQLSDSFLDYNKPDFPINQININSNIPDLLTSYFQQDHQTNIMSSYLFMMCQQNLLSSVYSSLMMPDWQLPNFNFGNIPSPHNLYSTKKSEIINNKENHLENINNKDQAEKHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDNKPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTEMLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQTHKRKKSNSLENSKSNDGESKKTDSDGCNTNVSLNSQI 519

The following BLAST results are available for this feature:

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Human
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Celegans
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Fly
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Zebrafish
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Xenopus
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Mouse
BLAST of Mushroom body large-type Kenyon-related protein vs. UniProt/SwissProt
BLAST of Mushroom body large-type Kenyon-related protein vs. TrEMBL
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Cavefish
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Sea Lamprey
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Yeast
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Nematostella
BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Medaka
BLAST of Mushroom body large-type Kenyon-related protein vs. Planmine SMEST

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
LCOR	4.168e-12	61.22	ligand dependent nuclear receptor corepressor [Sou...	[more]
LCOR	4.481e-12	61.22	ligand dependent nuclear receptor corepressor [Sou...	[more]
LCOR	4.481e-12	61.22	ligand dependent nuclear receptor corepressor [Sou...	[more]
LCOR	4.481e-12	61.22	ligand dependent nuclear receptor corepressor [Sou...	[more]
LCORL	1.180e-10	55.56	ligand dependent nuclear receptor corepressor like...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
mbr-1	6.678e-13	61.70	Mblk-1-related factor 1 [Source:UniProtKB/Swiss-P...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Eip93F	5.100e-12	61.70	gene:FBgn0264490 transcript:FBtr0112874	[more]
Eip93F	5.113e-12	61.70	gene:FBgn0264490 transcript:FBtr0084169	[more]
Eip93F	5.463e-12	61.70	gene:FBgn0264490 transcript:FBtr0330384	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lcor	1.761e-12	63.27	ligand dependent nuclear receptor corepressor [Sou...	[more]
CR769781.1	1.043e-10	58.82	ligand dependent nuclear receptor corepressor-like...	[more]
lcorl	1.053e-10	58.82	ligand dependent nuclear receptor corepressor-like...	[more]
CR762426.1	1.071e-10	58.82	ligand dependent nuclear receptor corepressor-like...	[more]
CR391911.1	1.168e-10	58.82	ligand dependent nuclear receptor corepressor-like...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
lcor	1.886e-11	61.22	ligand dependent nuclear receptor corepressor [Sou...	[more]
trmt5	3.405e-9	54.90	tRNA methyltransferase 5 [Source:Xenbase;Acc:XB-GE...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Lcor	3.003e-12	61.22	ligand dependent nuclear receptor corepressor [Sou...	[more]
Lcor	3.132e-12	61.22	ligand dependent nuclear receptor corepressor [Sou...	[more]
Lcor	3.132e-12	61.22	ligand dependent nuclear receptor corepressor [Sou...	[more]
Lcorl	9.053e-11	55.56	ligand dependent nuclear receptor corepressor-like...	[more]
Lcorl	1.494e-10	55.56	ligand dependent nuclear receptor corepressor-like...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|G5EGQ5\|MBR1_CAEEL	8.495e-12	61.70	Mblk-1-related factor 1 OS=Caenorhabditis elegans ...	[more]
sp\|Q96JN0\|LCOR_HUMAN	2.152e-11	61.22	Ligand-dependent corepressor OS=Homo sapiens OX=96...	[more]
sp\|Q6ZPI3\|LCOR_MOUSE	2.191e-11	61.22	Ligand-dependent corepressor OS=Mus musculus OX=10...	[more]
sp\|Q95YM8\|MBLK1_APIME	9.612e-11	61.70	Mushroom body large-type Kenyon cell-specific prot...	[more]
sp\|Q8N3X6\|LCORL_HUMAN	8.734e-10	55.56	Ligand-dependent nuclear receptor corepressor-like...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1Z1R179	0.000e+0	99.44	Mushroom body large-type Kenyon-related protein OS...	[more]
A0A1S3JRV9	3.048e-15	32.99	ligand-dependent nuclear receptor corepressor-like...	[more]
A0A1I8BYX5	3.660e-13	68.63	Uncharacterized protein OS=Meloidogyne hapla OX=63...	[more]
A0A0R3W630	3.853e-13	46.07	HTH psq-type domain-containing protein OS=Taenia a...	[more]
A0A0V1BHW2	1.854e-12	39.83	Mushroom body large-type Kenyon cell-specific prot...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
lcor	3.161e-13	56.90	ligand dependent nuclear receptor corepressor [Sou...	[more]
lcor	3.867e-13	56.90	ligand dependent nuclear receptor corepressor [Sou...	[more]
LCORL	1.584e-10	59.18	ligand dependent nuclear receptor corepressor like...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000003404.1	9.728e-11	55.10	pep scaffold:Pmarinus_7.0:GL476560:346958:365324:1...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Mushroom body large-type Kenyon-related protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4


Match Name	E-value	Identity	Description
lcor	3.057e-13	48.05	ligand dependent nuclear receptor corepressor [Sou...	[more]
lcor	3.057e-13	48.05	ligand dependent nuclear receptor corepressor [Sou...	[more]
lcor	4.511e-13	48.05	ligand dependent nuclear receptor corepressor [Sou...	[more]
lcor	5.265e-13	48.05	ligand dependent nuclear receptor corepressor [Sou...	[more]

BLAST of Mushroom body large-type Kenyon-related protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000070784.1	0.000e+0	99.63	SMESG000070784.1	[more]
SMESG000070784.1	0.000e+0	96.10	SMESG000070784.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30009090 ID=SMED30009090|Name=Mushroom body large-type Kenyon-related protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1840bp
CAGTTTTTTTTTAATATATTATAATCAAATATATTTCTCGTCTGTCATCG
TCGATTAAATTTCGGATTCACTCGACCGATGTATTGCTCAAAATGTTACC
ATGAACGAAAATATACCCGGCTCGAATTAGCAACCTGGCAGGATAAAATT
CCAGTAATCGTTGGTATAGAAGAAATTGTTAAAACAATATTTGAATATTC
ATTTGACCAAGTCGATGAAGATAAGCCCATTAAAACAACAGTAATCAAAG
ACTGGAATGAAGAAGAAATTTACTGTTTGTGTGAAAAAAAGATTTCCGAA
ATCAACAATTCTCACGAGCACGTATCACAGTCAGAACCGCTGGACCTGTC
GTTATCTAGTCCCACCTCAATCAATGAAAAAATTGACTATCAAAGTCCAC
GAAAACACGTTATCTCTAATAGTAGTTATTCTGAAAGAGAATTGATCTCA
GCCGTTCGTGCCATATGTTGCGGTCGAATAGGTACCAGACGTGCTGCTGC
ACTTTATGGAATTCCACGTTCAACACTGAGAAATAGAATTTTCAAAGTTT
ATGACGCCAAGAAAATTCACGACACTGACCAAAGAATGTCAATGGTAGAC
TTTTTTAAAAAAATCTTAAAAGATGACTCAATGTTCACTAATCTTTTTCA
TCAAAAATATCAACGTGAAAACAAGGAAGAAAAAAAGAAAACTGTTATAA
CAGAAAAAGAAAACAATAAAGTTCATTTCCGACAGAAAGAAAATCATGTC
AGCAATAAAGAATTGTTTAAAAATGAGCTCAATGAAATTATCAAGCATCA
ACAGAAAAAAGATTCCAGCAGGATTCAAGAAATTCAACTTTCCGATTCAT
TCCTTGATTATAATAAACCAGATTTTCCTATAAATCAAATTAATATTAAT
TCCAACATTCCAGACTTATTAACTTCTTATTTTCAACAAGATCATCAAAC
TAATATTATGTCAAGCTATTTATTTATGATGTGTCAGCAAAACCTTTTAT
CTTCTGTGTACAGCTCATTAATGATGCCCGATTGGCAGCTACCGAATTTT
AATTTTGGAAACATTCCTTCTCCCCATAATTTGTATTCTACTAAAAAGTC
AGAAATCATTAATAACAAAGAGAATCATTTGGAAAATATAAATAACAAAG
ATCAAGCAGACAAACATTCGATTCTCGAAACAGAACATTTTTATAATCAG
CCGTTAAATTTTGCCAAGAATTCTCTTGGCGAAATAAACATATCTTCCGA
AATATGTAAAAATGATCAATCAGACAACAAACCGGAAGAGTCCATTGAAG
AATCTGACACTTCTGTCAGTGCTCCATCAAAAGTAACAAATGAATTCAAT
ATCGCAGCTCTATCAGATGAGATCTCTGAATCCTCTCGTCACAAAAAAAG
AGGTCATTATCGTCAGTACAATACGGAGATGCTAAACAAGGCAATAGATG
CTGTAAGATTTGGCGAAATGAGCGTTCACAAGGCCGGAAATCACTTTGGA
GTGCCTCATTCTACTTTGGAATACCGAGTAAAACAAATGACTGAAGGATT
GGCAGCTGAGAAATTATTAAATAAACAGACTCACAAAAGAAAAAAGTCAA
ATTCGTTAGAAAATTCCAAAAGCAATGATGGAGAATCAAAAAAAACTGAT
TCAGATGGCTGTAATACGAATGTTTCTTTAAATTCTCAAATTTAGTGTCC
TATTGTTAGGAAATTAAATGAATTTGATTGGCATAATATTTATAAAAAAA
TAAATTTTTATTCAATGTCACAAAATATTTTTTGTAAAAATCTTGAAATC
TGATAAAAATCTTTATTATTGTTAAAAAAAGTTTTGCTCA

protein sequence of SMED30009090-orf-1

>SMED30009090-orf-1 ID=SMED30009090-orf-1|Name=SMED30009090-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=539bp
MYCSKCYHERKYTRLELATWQDKIPVIVGIEEIVKTIFEYSFDQVDEDKP
IKTTVIKDWNEEEIYCLCEKKISEINNSHEHVSQSEPLDLSLSSPTSINE
KIDYQSPRKHVISNSSYSERELISAVRAICCGRIGTRRAAALYGIPRSTL
RNRIFKVYDAKKIHDTDQRMSMVDFFKKILKDDSMFTNLFHQKYQRENKE
EKKKTVITEKENNKVHFRQKENHVSNKELFKNELNEIIKHQQKKDSSRIQ
EIQLSDSFLDYNKPDFPINQININSNIPDLLTSYFQQDHQTNIMSSYLFM
MCQQNLLSSVYSSLMMPDWQLPNFNFGNIPSPHNLYSTKKSEIINNKENH
LENINNKDQADKHSILETEHFYNQPLNFAKNSLGEINISSEICKNDQSDN
KPEESIEESDTSVSAPSKVTNEFNIAALSDEISESSRHKKRGHYRQYNTE
MLNKAIDAVRFGEMSVHKAGNHFGVPHSTLEYRVKQMTEGLAAEKLLNKQ
THKRKKSNSLENSKSNDGESKKTDSDGCNTNVSLNSQI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0000461	lateral branch

Vocabulary: **INTERPRO**
Term	Definition
IPR007889	HTH_Psq
IPR009057	Homeobox-like_sf

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 117..157 e-value: 2.8E-12 score: 47.9 coord: 447..488 e-value: 1.7E-17 score: 64.6
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 393..417
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 504..524
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 496..538
None	No IPR available	PANTHER	PTHR21545	TRANSCRIPTION FACTOR MLR1/2	coord: 96..198 coord: 430..491
None	No IPR available	PANTHER	PTHR21545:SF13	ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C	coord: 96..198 coord: 430..491
IPR007889	DNA binding HTH domain, Psq-type	PFAM	PF05225	HTH_psq	coord: 121..156 e-value: 3.9E-8 score: 32.9 coord: 450..487 e-value: 2.0E-12 score: 46.6
IPR007889	DNA binding HTH domain, Psq-type	PROSITE	PS50960	HTH_PSQ	coord: 107..160 score: 8.846
IPR007889	DNA binding HTH domain, Psq-type	PROSITE	PS50960	HTH_PSQ	coord: 438..490 score: 16.599
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 115..164
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 442..489

Main menu

Mushroom body large-type Kenyon-related protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 14

Owlery

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