Arginase

Overview
NameArginase
Smed IDSMED30008978
Length (bp)1379
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Arginase (SMED30008978) t-SNE clustered cells

Violin plots show distribution of expression levels for Arginase (SMED30008978) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Arginase (SMED30008978) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Arginase (SMED30008978) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30008978

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30008978SMESG000011875.1 dd_Smed_v4_6599_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30008978SMESG000011875.1 dd_Smed_v4_6599_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30008978SMESG000011875.1 dd_Smed_v4_6599_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Arginase vs. Ensembl Human
Match: AGMAT (agmatinase [Source:HGNC Symbol;Acc:HGNC:18407])

HSP 1 Score: 72.4034 bits (176), Expect = 3.122e-13
Identity = 66/300 (22.00%), Postives = 134/300 (44.67%), Query Frame = 3 
Query:  360 SPNGIIRIGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIE-SYRTGILIVNMIYYFM 1256
            SP G+     IG P+D G      RPGA  GP  +R      G +  S   +  + + + D GD  +N  +L+ +    +   + I+  G + +++GG +  ++P    +++ H           + ++++DAH D      G++ + G+PFR+ ++         V+   +GS  + +   Y + +   ++  +D           + S V    ++        +++SFD+D++  +  PG   P + GLT ++AL I     +  NV   D+ E +P  + S  T +L  N+++  +
Sbjct:   67 SPEGL-DAAFIGVPLDTGT---SNRPGARFGPRRIREESVMLGTVNPSTGALPFQSLMVADLGDVNVNLYNLQDSCRRIQEAYEKIVAAGCIPLTLGGDHTITYPILQAMAKKH---------GPVGLLHVDAHTDTTDKALGEKLYHGAPFRRCVDEGLLDCKRVVQIGIRGSSTTLDPYRYNRSQGFRVVLAEDCW---------MKSLVPLMGEVRQQMGGKPIYISFDIDALDPAYAPGTGTPEIAGLTPSQALEI-IRGCQGLNVMGCDLVEVSPPYDLSGNTALLAANLLFEML 343
[Close]
BLAST of Arginase vs. Ensembl Human
Match: ARG2 (arginase 2 [Source:HGNC Symbol;Acc:HGNC:664])

HSP 1 Score: 56.225 bits (134), Expect = 5.072e-8
Identity = 62/267 (23.22%), Postives = 107/267 (40.07%), Query Frame = 3 
Query:  525 GIEIKDFGDT--------------ILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDV-RPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGN-----IIWLKDLQGSLIDHSNK--INSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSI-----ESYRTGILIVNMI 1244
            G  +KDFGD               I+N   +  A+     +V   + DGY  +++GG  D S    +G    H +H       ++ +V +DAH D+  PL        G P   +L    +       F+      SS  + Y+ ++  +     I+   D+Q   +   ++  I   ++R   L+   +   + +SFD+D+   +  P    P V GLT  E + I  E      +   D+ E NP +     E+  T  L V++I
Sbjct:   62 GCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGG--DHSL--AIGTISGHARHCP-----DLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVI 319
[Close]
BLAST of Arginase vs. Ensembl Zebrafish
Match: agmat (agmatine ureohydrolase (agmatinase) [Source:ZFIN;Acc:ZDB-GENE-060929-696])

HSP 1 Score: 79.7221 bits (195), Expect = 8.184e-16
Identity = 69/298 (23.15%), Postives = 128/298 (42.95%), Query Frame = 3 
Query:  387 LIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNII-----WLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLF--DISEFNPSIESY-RTGILIVNMIYYFM 1256
             IG PID G     G         A   +I+   A          E I++ D GD  +N  DLK      +   + I+  G + +++GG +  ++P    ++E H           + ++++DAH D   ++ G+E   G+PFR+ ++          +   +GS  S ++ E+ + +   ++     W K    SL+    ++ S + R            V++SFD+DS+  +  PG   P + GLT  + L I      C+ + L   D+ E +P  ++   T +L  N+++  M
Sbjct:   89 FIGVPIDTGTSNRPGARFGPRHIRAESAMIR---AYCGWTRAAPYESIKVADIGDINVNLFDLKDTCKKIQEAYRKIVATGCIPLTLGGDHTIAYPILQAVAERH---------GPVGLIHVDAHADTSDMILGEEIGHGTPFRRCVDEGLLDCKRVAQIGLRGSGYSPDNYEWSRGQGFRVVEAVECWHK----SLVPLMEEVRSQMGR----------GPVYLSFDIDSLDPAFAPGTGTPEIAGLTPIQGLEIIR---GCRGLNLVGCDLVEVSPPYDTTGNTALLGANLLFEMM 357
[Close]
BLAST of Arginase vs. Ensembl Xenopus
Match: clca1.3 (chloride channel accessory 1 gene 3 [Source:Xenbase;Acc:XB-GENE-6043674])

HSP 1 Score: 73.559 bits (179), Expect = 1.559e-13
Identity = 55/253 (21.74%), Postives = 111/253 (43.87%), Query Frame = 3 
Query:  501 SEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSI-ESYRTGILIVNMIYYFM 1256
            S      E + + D GD  +N  DLK +    +   + I+  G + +++GG +  ++P    ++E H           + +V++DAH D      G++ + G+PFR+ ++         V+   +GS  S++   + + +   ++  +D             S V   +++ +      V++SFD+D +  S  PG   P + GLT ++ L I     +  NV   D+ E  P   +S  T +   N+++  +
Sbjct:  147 STRAAPFESLMVADIGDVNVNLYDLKDSCRRIRETYQKIMAAGCIPLTLGGDHTITYPILQAVAEKH---------GPVGLVHVDAHTDTGDTALGEKIYHGTPFRRCVDEGLLDCKRVVQIGIRGSSYSADPYGFCREQGFRVVLAEDCW---------FRSLVPLMAEVRSQMGAGPVYISFDIDGLDPSFAPGTGTPEIAGLTTSQGLEI-IRGCRGLNVVGCDLVEVAPVYDQSGNTALTGANLLFEML 380
[Close]
BLAST of Arginase vs. Ensembl Mouse
Match: Agmat (agmatine ureohydrolase (agmatinase) [Source:MGI Symbol;Acc:MGI:1923236])

HSP 1 Score: 63.1586 bits (152), Expect = 2.152e-10
Identity = 59/303 (19.47%), Postives = 130/303 (42.90%), Query Frame = 3 
Query:  351 MSESPNGIIRIGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIE-SYRTGILIVNMIYYFM 1256
            +  SP G+     IG P+D G     G          +R      GA+  S   +  + + + D G+  +N  +L+ + L  +   +++L  G + +++GG    ++P    +++ H           + +V++ AH +       ++ +  +PFR+ ++     S   V+   +GS  + +   Y + +   ++  +D           + S V   +++        +++SF +D++  +  PG   P + GLT ++AL I     +  NV   D+ E +P  + S  T +L  N+++  +
Sbjct:   70 LQSSPEGL-DAAFIGVPLDTGTSNRPGARFGPCR---IREESLMLGAVNPSTGALPFQSLRVADLGNVNVNLYNLQDSCLLIREAYQNVLAAGCIPLTLGGDQTITYPILQAVAKEH---------GPVGLVHVGAHTNTTDKPREEKVYHRTPFRRSVDEGLLDSKRVVQIGIRGSSRTLDPYRYSRSQGFRVVLAEDCW---------MKSLVPLMAEVRQQMGGKPLYISFAIDALDPAYAPGTGTPEIAGLTPSQALEI-IRGCQGLNVVGCDLVEVSPPYDLSGNTALLAANLLFEML 349
[Close]
BLAST of Arginase vs. UniProt/SwissProt
Match: sp|Q8XW30|HUTG_RALSO (Formimidoylglutamase OS=Ralstonia solanacearum (strain GMI1000) OX=267608 GN=hutG PE=3 SV=1)

HSP 1 Score: 105.916 bits (263), Expect = 4.266e-24
Identity = 83/298 (27.85%), Postives = 144/298 (48.32%), Query Frame = 3 
Query:  381 IGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQG-SQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIE-SYRTGILIVNMIYYFMMGVA 1268
            + L G+  D G+ RN GR GA  GP A+R ++    A           G  I D GD     + L+ A      ++  +LD G   I++GGG++ ++ +F GL+ +     ++     + I+N+DAH D+R    G+   SG+PFRQ+ E        F  +AC G S  ++    + + ++  + WL+D +  L+ H  ++  TV  F   + D  H  V+++  +D + +   PGVS P+  G+       I         +RL D++E NPS++  +RT  +   ++   + GVA
Sbjct:   42 VALAGFACDAGIARNHGRVGAQAGPAAIRRMLANLPA---------RPGRAIVDAGDVTCRGDALEAAQDALSGVLHGLLDRGAFPIALGGGHELAWASFGGLARHLAARSAQP--PRIGILNLDAHFDLR---AGERGSSGTPFRQIAEDCARRGWPF-RYACLGISAYANTEALFARARQLGVRWLRDDEMDLL-HLPRVLQTVDAF---LADVDH--VYLTICLDVLPAGVAPGVSAPSARGVPMEVIEPIVDRVAASGKLRLADVAELNPSLDIDHRTARVAARLVARVVDGVA 318
[Close]
BLAST of Arginase vs. UniProt/SwissProt
Match: sp|A4SSN4|HUTG_AERS4 (Formimidoylglutamase OS=Aeromonas salmonicida (strain A449) OX=382245 GN=hutG PE=3 SV=1)

HSP 1 Score: 93.9745 bits (232), Expect = 5.689e-20
Identity = 81/293 (27.65%), Postives = 145/293 (49.49%), Query Frame = 3 
Query:  381 IGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQG-SQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIE----SYRTGILIVNMI 1244
            + L+G+  D GV RN GR GAAG P A+R L+       NS + ++     + D GD   ++ DL  AH      V S+LD+G+  + +GGG++ +F ++ GL+    +H    G   + I+N DAH D+R  +E  +  SG+PF Q+ E  T     F  +AC G ++ ++    + +     + ++KD   S       + + +      I   + D+++++ D+D +  +  PGVS PA  G+       +         +RL D++E+NP+++    S R    +V+ +
Sbjct:   44 VALVGFACDEGVRRNKGRVGAAGAPLAIRKLLA------NSAWHLTRP---VYDSGDLTCDDGDLDAAHARLAERVASLLDEGHFPLVLGGGHEVAFGSWNGLN----RHL--VGQGRVGIINFDAHFDLRRKVE--QASSGTPFFQIAEQCTAQGTPF-HYACLGVAETANTQALFARADALGVWYVKDEAMS----ERSLPALLSGLDSFI--AQSDHIYLTIDLDVLPGAVMPGVSAPAARGVELAIIEPLIAHIQASGKLRLADLAEYNPNLDQDNRSARVAARLVHQL 312
[Close]
BLAST of Arginase vs. UniProt/SwissProt
Match: sp|Q0S7R0|HUTG_RHOJR (Formimidoylglutamase OS=Rhodococcus jostii (strain RHA1) OX=101510 GN=hutG PE=3 SV=1)

HSP 1 Score: 92.4337 bits (228), Expect = 1.914e-19
Identity = 64/246 (26.02%), Postives = 123/246 (50.00%), Query Frame = 3 
Query:  522 EGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKG-NIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIE----SYRTGILIVNMI 1244
            E + + D G   + +N L+   +   ++V + LD G   + +GGG++ ++  +LGL++   +   +     + I+N+DAH D+R       P SG+PFRQ+LE   + S   ++++  G    SN        +G ++ +L D   S+ D  +++   V  F   ++D   D V+++ D+D + ++  PGVS PA  G+ A     +C        + + D++E NPS +    + RT   +++ I
Sbjct:   80 EPLRVYDAGTVAVTDNRLEAGQMALGSVVAATLDAGQFPVVLGGGHEVAYGTYLGLAQAAVRTPKR----RIGILNLDAHFDLR---SDPVPSSGTPFRQILE-QEHASGTALQYSVLGISQPSNTTALFDTARGYDVRYLLDDDCSVSDR-HRVAVFVSEF---LSDV--DLVYLTIDLDVLPAAVAPGVSAPAAYGVPAETIQFVCDAVAASGKLAVCDVAELNPSFDIDNRTARTAARLIHRI 311
[Close]
BLAST of Arginase vs. UniProt/SwissProt
Match: sp|Q471H6|HUTG_CUPPJ (Formimidoylglutamase OS=Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) OX=264198 GN=hutG PE=3 SV=1)

HSP 1 Score: 92.0485 bits (227), Expect = 2.779e-19
Identity = 78/294 (26.53%), Postives = 144/294 (48.98%), Query Frame = 3 
Query:  387 LIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQG-SQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNK-INSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMG 1262
            L+G+  D GV+RN GR GAA GP+A+R  +    A     +G+      + D G+      DL++A L     V +IL  G   + +GGG++ ++  + GL  + +   +++ D  +LI+NIDAH D+R         SG+PF Q+          F ++ C G S+ S+    + +     + +++D     +D   + + S +   +  I+ T H  V+++ D+D++ ++  PGVS PA  G+       I   A +   +R  D++E+NP  +    G  +   + + ++G
Sbjct:   46 LLGFGCDAGVLRNQGRAGAAHGPDAIRQALANVPA-----HGLP----ALYDAGNIACEHGDLESAQLALAGSVHNILSRGGFPLVLGGGHEVAWGTWQGLRAHLD---ARNDDGRLLIINIDAHFDLR---TSRPASSGTPFDQIANACAERGQPF-DYVCLGVSRLSNTPALFSRAHALGVSYVED-----VDMQERHLASRLAELAARIDATDH--VYLTIDLDALPATVMPGVSAPAAYGVPLPVVEEIALLARRSGKLRAADLAEYNPQYDRDNLGARVAARLAWRLLG 316
[Close]
BLAST of Arginase vs. UniProt/SwissProt
Match: sp|A0KF85|HUTG_AERHH (Formimidoylglutamase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240) OX=380703 GN=hutG PE=3 SV=1)

HSP 1 Score: 91.2781 bits (225), Expect = 4.070e-19
Identity = 83/295 (28.14%), Postives = 143/295 (48.47%), Query Frame = 3 
Query:  381 IGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHS---NKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIE----SYRTGILIVNMI 1244
            + L+G+  D GV RN GR GAAG P AVR L+       NS + +   G  + D GD    + DL  AH      V  +LD+G+  + +GGG++ +F ++ GL+    +H   +G   + I+N DAH D+R  LE  +  SG+PF Q+ E        F  +AC G   ++N        +   +W       ++D +    ++ + +      I   + D+++++ D+D + ++  PGVS PA  G+       +         +RL D++E+NPS++    S R    +V+ +
Sbjct:   44 VALVGFACDEGVRRNKGRVGAAGAPLAVRKLLA------NSAWHL---GRPVYDRGDVNCEDGDLDAAHGRLAERVARLLDEGHFPLVLGGGHEVAFGSWSGLN----RHL--AGRGRVGIINFDAHFDLRMKLE--QASSGTPFFQIAEQCAIQGTPFT-YACLGVAETANTQALFARAEALGVW------HVLDEAMTPAELPALLSGLDAFI--ARCDHLYLTIDLDVLPAAVMPGVSAPAARGVELAVIEPLIAHIRASGKLRLADLAEYNPSLDQDNRSARVAARLVHQL 312
[Close]
BLAST of Arginase vs. TrEMBL
Match: T2M6F0 (Agmatinase, mitochondrial (Fragment) OS=Hydra vulgaris OX=6087 GN=AGMAT PE=2 SV=1)

HSP 1 Score: 269.626 bits (688), Expect = 9.224e-84
Identity = 155/329 (47.11%), Postives = 213/329 (64.74%), Query Frame = 3 
Query:  303 NNLNMNKFDDPRLGNLMS--ESPNGIIRIGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLD---FVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMGVACR 1274
            +N  M+K  DPRLG+L+    S N   ++ ++GYP D+GV RN GR G+  GP  +R  ++K G +IN E+ I L  I  +D GD  +++  L+  H    + V S+L+DG++VI +GGGNDQS+PN  GL        S     N+ +VNIDAHLDVRPL+ G   HSGSPFRQ+LE +  Y  D   F+EFA QGSQCS+ HV+Y++ K G I+WL ++      H    N     F  ++ND +   +FVSFD+DSI+ +DCPGVSCP+V GL+A +AL IC+ AGK    +L D+SEFNP+IE  RT  L+VNMIYYF++G+A R
Sbjct:    2 SNQKMSKIGDPRLGDLLQVPYSGNKKAKVAILGYPCDIGVERNNGRVGSKNGPCCIRKKLEKMGTVINPEFNIDLNNIHFEDRGDIQISDT-LENNHEILASEVSSLLNDGFIVIVVGGGNDQSYPNAKGL-------MSSMKSGNIGVVNIDAHLDVRPLINGSLAHSGSPFRQLLEDDM-YIKDKGMFLEFASQGSQCSAEHVKYIQSKSGKIVWLSEI------HKKGANEC---FKNVLNDLQGRPLFVSFDIDSIKGADCPGVSCPSVIGLSAQDALDICFLAGKNTYTKLLDLSEFNPNIEEDRTARLVVNMIYYFLLGIAER 312
[Close]
BLAST of Arginase vs. TrEMBL
Match: A0A2P6NAV7 (Putative arginase (Fragment) OS=Planoprotostelium fungivorum OX=1890364 GN=PROFUN_11147 PE=3 SV=1)

HSP 1 Score: 242.276 bits (617), Expect = 6.082e-73
Identity = 153/320 (47.81%), Postives = 201/320 (62.81%), Query Frame = 3 
Query:  327 DDPRLGNLMS-ESPNG--IIRIGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILD-DGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMGVACR 1274
            DDPRLG++++ E P G     + L+G+P D GV RNGGR GA  GP  +R L K+ G ++N EY I L  I + D GD I  ++ L+ AH   +  V ++L   G +   +GGGNDQSFPN   L E  E         ++ ++NIDAHLDVRPL EG + HSGSPFRQ++E +      FVEFA QG+QCS+ HV+Y+  K G I WL  L+ S           V+ F ++I D   DNVFVSFD+D+I  +DCPGVS     G+TA EAL ICY AG+   VRLFD+SE+NP +E+YRTG L+ NM Y+F MG+A R
Sbjct:    8 DDPRLGDIITHEEPVGQKPAAVALLGFPYDEGVSRNGGRTGAREGPSTLRTLYKRMGTVVNPEYDIDLRTIGVHDVGD-IDPDHPLEEAHSRLRARVSNLLSIKGVVPFVVGGGNDQSFPNGSALIESCEGQ-------SVGVINIDAHLDVRPLKEG-KTHSGSPFRQLMEESGLEPQRFVEFAAQGNQCSATHVKYLTEKGGKIHWLSSLRSS-------DRPVVQVFREII-DHLGDNVFVSFDIDAISGADCPGVSAVGTIGITAQEALDICYAAGRHPKVRLFDLSEYNPQVEAYRTGRLVANMFYFFSMGLAQR 310
[Close]
BLAST of Arginase vs. TrEMBL
Match: L8HFF6 (Arginase OS=Acanthamoeba castellanii str. Neff OX=1257118 GN=ACA1_074670 PE=3 SV=1)

HSP 1 Score: 239.195 bits (609), Expect = 3.475e-72
Identity = 138/316 (43.67%), Postives = 183/316 (57.91%), Query Frame = 3 
Query:  327 DDPRLGNLMSESPNGIIRIGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMGVACR 1274
            DDPRLG L+   P  +  I ++G+P D GV       G  GGPEA R  + K G ++N E+GI L G++I D GD  +    L+  H +  + V  I+  G +   IGGGNDQS+PN  GL        +     +M  +NIDAH DVRPL EG + HSGSPFR ++E +      FVEFA QG+QCS+ H +Y+   KG I+WL D++                        + + +FVSFD+DSI+SSDCPGVS P   GLT+ +AL IC+ +GK   VRL D+SE+NP +E YRTG L+  M YYF MGVA R
Sbjct:    7 DDPRLGALVV--PGEVGDIVVVGFPSDEGV---KRNGGRPGGPEAARKHLMKVGPLVNPEFGIDLRGLKIVDAGDIAVPT--LEEGHESLASTVGKIIGHGGIPFVIGGGNDQSYPNARGL-------LAHVPSGSMAAINIDAHFDVRPLKEG-KVHSGSPFRLLIEDDRFQGEHFVEFASQGNQCSAVHAQYITEHKGKIVWLSDIK-----------------------KRCEAIFVSFDIDSIKSSDCPGVSAPGAVGLTSEDALEICFVSGKNPKVRLVDLSEYNPLVEEYRTGRLVATMFYYFAMGVASR 284
[Close]
BLAST of Arginase vs. TrEMBL
Match: A0A2P6MZT2 (Putative arginase OS=Planoprotostelium fungivorum OX=1890364 GN=PROFUN_13393 PE=3 SV=1)

HSP 1 Score: 240.736 bits (613), Expect = 8.636e-72
Identity = 152/320 (47.50%), Postives = 201/320 (62.81%), Query Frame = 3 
Query:  327 DDPRLGNLMS-ESPNG--IIRIGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILD-DGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMGVACR 1274
            DDPRLG++++ E P G     + L+G+P D GV RNGGR GA  GP  +R L K+ G ++N EY I L  I + D GD I  ++ L+ AH   +  V ++L   G +   +GGGNDQSFPN   L E  E         ++ ++NIDAHLDVRPL EG + HSGSPFRQ++E +      FVEFA QG+QCS+ HV+Y+  K G I WL  L+ S           V+ F ++I D   DN+FVSFD+D+I  +DCPGVS     G+TA EAL ICY AG+   VRLFD+SE+NP +E+YRTG L+ NM Y+F MG+A R
Sbjct:   51 DDPRLGDIITHEEPVGQKPAAVALLGFPYDEGVSRNGGRTGAREGPSTLRTLYKRMGTVVNPEYDIDLRTIGVHDVGD-IDPDHPLEEAHSRLRARVSNLLSIKGVVPFVVGGGNDQSFPNGSALIESCEGQ-------SVGVINIDAHLDVRPLKEG-KTHSGSPFRQLMEESGLEPQRFVEFAAQGNQCSATHVKYLTEKGGKIHWLSSLRSS-------DRPVVQVFREII-DHLGDNIFVSFDIDAISGADCPGVSAVGTIGITAQEALDICYAAGRHPKVRLFDLSEYNPQVEAYRTGRLVANMFYFFSMGLAQR 353
[Close]
BLAST of Arginase vs. TrEMBL
Match: A0A4V3SCY7 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009616 PE=3 SV=1)

HSP 1 Score: 238.81 bits (608), Expect = 2.410e-71
Identity = 152/340 (44.71%), Postives = 203/340 (59.71%), Query Frame = 3 
Query:  315 MNKFDDPRLGNLM---SESPNGIIR----IGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIK--DFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDS-NMLIVNIDAHLDVRPLLEGDE----PHSGSPFRQMLE-TNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQG--SLIDHSNKINSTVKRFSQLINDTK--HDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMGVACRS 1277
            MN+ DDPRLG L+    E  N   R    +GLI  P D GV RNGGR GA  GP  V +L+ + G + N E+ I+LE  EI+  D+G T  +  +L+  H   K +VK  L +    + IGGGNDQS+ N     E+     ++      + ++NIDAHLDVRPL++ ++     HSGSPFRQ+LE  +       +EFA QG QCS  HV+YV    G IIWL  L G  +  +H  +   +VK    ++ D +    +VF SFDVD+IQ++DCPGVSCP+  GL + EAL +CY AGK K V L DISEFNP +ES +T  LIVNMIY F++G + RS
Sbjct:    1 MNRPDDPRLGRLLIGRKEFDNLKDRAAKNVGLIRVPCDEGVDRNGGRVGARDGPSVVMDLLPRFGVLDNREWKINLETAEIQLVDYGSTGFS--NLEEVHSTLKGLVKDCLKNHLFPLCIGGGNDQSWANGAAWIEHLRTQSTQQDKGLKLTVINIDAHLDVRPLIKLEDGRQVSHSGSPFRQLLEMAHRQEDFKLIEFAAQGQQCSGEHVDYVHKHGGTIIWLSQLAGYETCTEHGGQHPKSVKIMQDILQDCEASERHVFFSFDVDAIQAADCPGVSCPSPVGLASREALGLCYVAGKSKAVDLMDISEFNPRVESTQTSRLIVNMIYCFLLGYSQRS 338
[Close]
BLAST of Arginase vs. Ensembl Cavefish
Match: agmat (agmatinase [Source:NCBI gene;Acc:103044008])

HSP 1 Score: 70.4774 bits (171), Expect = 6.803e-13
Identity = 62/309 (20.06%), Postives = 128/309 (41.42%), Query Frame = 3 
Query:  339 LGNLMSESPNGIIRIGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLF--DISEFNPSIESY-RTGILIVNMIYYFM 1256
            +G L  +S    +    IG PID G     G         +   +++   A  ++      E + + D GD  +N  DLK      +   + +L  G + +++GG +  ++P    ++E H           + +V++DAH D      G++   G+PFR+ +E         V+   +G+  S ++  + + +   ++ +++             S V    ++        V++SFD+D++     PG   P + GLT  + L I      C+ + L   D+ E +P  ++   T +   N+++  +
Sbjct:   52 MGKLPFQSSAAGLDAAFIGVPIDTGTSNRPGARFGPRQIRSESFMLR---AYNSATRAAPYESLMVADIGDVNVNLYDLKDTCRRIRETYREVLQTGCIPLTMGGDHTIAYPILQAVAERH---------GPVGLVHVDAHADTGDTSLGEKIGHGTPFRRCVEEGLLDCGRVVQIGLRGTGYSPDNYAWSREQGFRVVQVEECW---------YRSLVPLMEEVREQMGSGPVYLSFDIDALDPGFAPGTGTPEIAGLTPVQGLEIIR---GCRGLNLVGCDLVEVSPPYDTTGNTALTAANLLFEML 336
[Close]
BLAST of Arginase vs. Ensembl Sea Lamprey
Match: arg2 (arginase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-1334])

HSP 1 Score: 46.9802 bits (110), Expect = 5.183e-6
Identity = 63/295 (21.36%), Postives = 108/295 (36.61%), Query Frame = 3 
Query:  381 IGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNH--------------KNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDV-RPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMK---KGNIIWLKD--LQGSLIDHSNK--INSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNP 1199
            +G+IG P   G           GG E    L++K G +      I   G  + D GD    E    T    H                +V+ ++ DG   I+IGG +  +  +  G               N+ ++ +DAH D+  PL        G P   +L+  T+        +      +   + Y+ ++    G    LK+  +Q   + H ++  I   ++   + +N      + +S+D+D+   S  P    P + GLT  E L I  E      +   D+ E NP
Sbjct:   29 VGIIGVPFSKG--------QKRGGVEHAPMLLRKAGLVEK----IEEMGYNVADLGDLSFGEVKDDTPFQKHVPFPRTVGMACQGLAQVVRQVVCDGRTCITIGGDHSLAIGSVSG---------HAMARPNLGVIWVDAHADINTPLTSPSGNLHGQPLAFLLQELTSKVPAVPGLSWVSPCLTVQDIVYIGLRDIDPGEHYILKNYGMQYFSMRHVDRLGIRKVMEMSLEFLNPRGRRPIHLSYDIDAFDPSLAPATGTPVLGGLTYREGLYIAEEVHNSGCLSAMDLVEVNP 302
[Close]
BLAST of Arginase vs. Ensembl Nematostella
Match: EDO37777 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEW0])

HSP 1 Score: 55.4546 bits (132), Expect = 1.548e-8
Identity = 55/241 (22.82%), Postives = 103/241 (42.74%), Query Frame = 3 
Query:  516 SLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHD----NVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGI 1226
              E + + D GD  +N  ++       +  ++  + DG   +++GG +  ++P    +   H           + +V++DAH+D+   +  +  + GSPF +  E         V+   +GS   +N          NI   KDL   ++     ++   K  + L+ + +       V++SFD+D +  S  PG   P + GLTA + L I     +  NV   D+ E +P  ++  TGI
Sbjct:   66 PFESLMVADVGDIPINNFNISKTVDIIRTKIEEFICDGCFPLTMGGDHTITYPILQAIKNKH---------GPVGLVHVDAHMDLHNKMCDEAVYHGSPFFRAFEEGLLDPKRVVQIGLRGSLYDNNAY--------NI--PKDLGFRVVP---AVDCWYKSMAPLMAEVQEQMGDGPVYISFDIDGLDPSIAPGTGTPEIGGLTAIQGLEIV-RGCQGLNVVGGDLVEVSPPYDT--TGI 281
[Close]
BLAST of Arginase vs. Ensembl Nematostella
Match: EDO41169 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S529])

HSP 1 Score: 46.9802 bits (110), Expect = 9.087e-6
Identity = 40/181 (22.10%), Postives = 74/181 (40.88%), Query Frame = 3 
Query:  714 SKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLF--DISEFNPSIE-SYRTGILIVNMIY 1247
            SK+    + +V++DAH D        +   GSPF   +E         V+   +G        ++   K   +++ KD     +D             ++        V++SFD+D +     PG   P V GLT+ +A+ I      C+ + +   D+ E +P  + S  T +L  N+++
Sbjct:  124 SKAKHGPVGMVHVDAHTDTATGANNVKIFHGSPFYWAVEEGLLDPRRVVQIGLRGPWYDEAEYDWATDKGFRLVFAKDCWHKCLD---------PLMGEVRAQMGDGPVYISFDIDGLDPVYAPGTGTPEVAGLTSIQAMEIVR---GCRGLDIVGCDLVEVSPPYDASGMTALLAANILF 292
[Close]
BLAST of Arginase vs. Ensembl Medaka
Match: agmat (agmatinase [Source:NCBI gene;Acc:101159353])

HSP 1 Score: 73.1738 bits (178), Expect = 9.054e-14
Identity = 54/239 (22.59%), Postives = 109/239 (45.61%), Query Frame = 3 
Query:  522 EGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLF--DISEFNPSIESYRTGILI 1232
            E + + D GD  +N  DLK      K   + IL  G + +++GG +  ++P    ++E +           + +V++DAH D   ++ G++   G+PFR+ +E         V+   +GS  S++  E+ + +   ++ +++             S     S++        V++SFD+D++     PG   P + GLT  + + I      C+ + L   D+ E +P  ++  TG+L+
Sbjct:  119 ESLVVADIGDINVNVYDLKDTCRRIKEAYRKILSTGCIPLTMGGDHTIAYPILQAVAEKY---------GPVGLVHVDAHADTSDVVLGEKIGHGTPFRRCVEEGLLNCERVVQIGLRGSGYSADSYEWSRAQGFRVVQVEECW---------FKSLAPLMSEVRAQMGSGPVYLSFDIDALDPGFAPGTGTPEIAGLTPIQGVEIIR---GCRGLNLVGCDLVEVSPPYDT--TGLLL 334
[Close]
BLAST of Arginase vs. Ensembl Medaka
Match: agmat (agmatinase [Source:NCBI gene;Acc:101159353])

HSP 1 Score: 71.2478 bits (173), Expect = 3.296e-13
Identity = 53/248 (21.37%), Postives = 111/248 (44.76%), Query Frame = 3 
Query:  522 EGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLF--DISEFNPSIESY-RTGILIVNMIYYFM 1256
            E + + D GD  +N  DLK      K   + IL  G + +++GG +  ++P    ++E +           + +V++DAH D   ++ G++   G+PFR+ +E         V+   +GS  S++  E+ + +   ++ +++             S     S++        V++SFD+D++     PG   P + GLT  + + I      C+ + L   D+ E +P  ++   T +   N+++  +
Sbjct:  119 ESLVVADIGDINVNVYDLKDTCRRIKEAYRKILSTGCIPLTMGGDHTIAYPILQAVAEKY---------GPVGLVHVDAHADTSDVVLGEKIGHGTPFRRCVEEGLLNCERVVQIGLRGSGYSADSYEWSRAQGFRVVQVEECW---------FKSLAPLMSEVRAQMGSGPVYLSFDIDALDPGFAPGTGTPEIAGLTPIQGVEIIR---GCRGLNLVGCDLVEVSPPYDTTGNTALTGANLLFEML 345
[Close]
BLAST of Arginase vs. Planmine SMEST
Match: SMESG000011875.1 (SMESG000011875.1)

HSP 1 Score: 626.32 bits (1614), Expect = 0.000e+0
Identity = 320/321 (99.69%), Postives = 320/321 (99.69%), Query Frame = 3 
Query:  315 MNKFDDPRLGNLMSESPNGIIRIGLIGYPIDLGVIXXXXXXXXXXXXEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMGVACRS 1277
            MNKFDDPRLGNLMSESPNGIIRIGLIGYPIDLGVIRNGGRPGAAGGPEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMGVAC S
Sbjct:    1 MNKFDDPRLGNLMSESPNGIIRIGLIGYPIDLGVIRNGGRPGAAGGPEAVRNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMGVACTS 321
[Close]
BLAST of Arginase vs. Planmine SMEST
Match: SMESG000028976.1 (SMESG000028976.1)

HSP 1 Score: 51.2174 bits (121), Expect = 7.960e-7
Identity = 57/268 (21.27%), Postives = 105/268 (39.18%), Query Frame = 3 
Query:  525 GIEIKDFGDT----ILNENDLKTAH---------LNHKNMVKSILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHLDV-RPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVKMKKGNIIW--------LKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDSIQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESYRTGILIVNMIYYFMMG 1262
            G+E+ DFG+     + N+ ++ +A          L+    +  I++  Y+ +++GG +  S    LG  + HE         N+ +V +DAH D+  PL        G P    +    N      EF       S+ HV Y+ ++  +           +K      +D    IN  ++   + +N        +SFDVD++     P        GL+  E + +C +      +   DI+E N  + SY   +  +N     ++G
Sbjct:   44 GVEVHDFGNIETAIVPNDTNIYSAKFPKSFLNNSLSIAKKITEIINKDYIPLTVGGDHTLSTGTILGHFQTHE---------NISVVWVDAHADINTPLSSVTGNMHGMPLAFSIIEMQNEMPWIEEFKDLPPVISAKHVVYIGLRDVDPYERYVLDKYKIKSFSMKNVDEVG-INCVIQEAIKSVNPNLDRYFHLSFDVDALDPMYAPSTGTRVPGGLSLREGIYLCEQLYNTGKLAAIDIAEINTQLGSYSDAMTTLNSGIKLILG 301
The following BLAST results are available for this feature:
BLAST of Arginase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
AGMAT3.122e-1322.00agmatinase [Source:HGNC Symbol;Acc:HGNC:18407][more]
ARG25.072e-823.22arginase 2 [Source:HGNC Symbol;Acc:HGNC:664][more]
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BLAST of Arginase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Arginase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Arginase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
agmat8.184e-1623.15agmatine ureohydrolase (agmatinase) [Source:ZFIN;A... [more]
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BLAST of Arginase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
clca1.31.559e-1321.74chloride channel accessory 1 gene 3 [Source:Xenbas... [more]
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BLAST of Arginase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Agmat2.152e-1019.47agmatine ureohydrolase (agmatinase) [Source:MGI Sy... [more]
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BLAST of Arginase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8XW30|HUTG_RALSO4.266e-2427.85Formimidoylglutamase OS=Ralstonia solanacearum (st... [more]
sp|A4SSN4|HUTG_AERS45.689e-2027.65Formimidoylglutamase OS=Aeromonas salmonicida (str... [more]
sp|Q0S7R0|HUTG_RHOJR1.914e-1926.02Formimidoylglutamase OS=Rhodococcus jostii (strain... [more]
sp|Q471H6|HUTG_CUPPJ2.779e-1926.53Formimidoylglutamase OS=Cupriavidus pinatubonensis... [more]
sp|A0KF85|HUTG_AERHH4.070e-1928.14Formimidoylglutamase OS=Aeromonas hydrophila subsp... [more]
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BLAST of Arginase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
T2M6F09.224e-8447.11Agmatinase, mitochondrial (Fragment) OS=Hydra vulg... [more]
A0A2P6NAV76.082e-7347.81Putative arginase (Fragment) OS=Planoprotostelium ... [more]
L8HFF63.475e-7243.67Arginase OS=Acanthamoeba castellanii str. Neff OX=... [more]
A0A2P6MZT28.636e-7247.50Putative arginase OS=Planoprotostelium fungivorum ... [more]
A0A4V3SCY72.410e-7144.71Uncharacterized protein OS=Opisthorchis felineus O... [more]
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BLAST of Arginase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
agmat6.803e-1320.06agmatinase [Source:NCBI gene;Acc:103044008][more]
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BLAST of Arginase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
arg25.183e-621.36arginase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-1334][more]
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BLAST of Arginase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Arginase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO377771.548e-822.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO411699.087e-622.10Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Arginase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
agmat9.054e-1422.59agmatinase [Source:NCBI gene;Acc:101159353][more]
agmat3.296e-1321.37agmatinase [Source:NCBI gene;Acc:101159353][more]
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BLAST of Arginase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000011875.10.000e+099.69SMESG000011875.1[more]
SMESG000028976.17.960e-721.27SMESG000028976.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008978 ID=SMED30008978|Name=Arginase|organism=Schmidtea mediterranea sexual|type=transcript|length=1379bp
TTTTATTGTATTTTGTTATGTATGTATATGGTGTGTGAATACAAATTAAA
ATATCAAGATAAAATAAAAATTGAAAAATATTATTAGTGATTCATGATAA
AACAAGTGCCTGTTTTCAATGTTGAAAGTTAGTTATGTCTACCACGATAG
TAGTTCTGTGAAAGTCTTTGCCAGACTGAGTAATTTCATTTACACACATT
CAATAAATTTGATTGGTCAGTCTTTATTGTCTCGTGGCATGGTAGAAAAC
GTCCAGGTCTCGTTTTTTTTTGTAAAAATTCAATCATTTGTATGCTGCAT
TAAACAATTTGAACATGAATAAATTTGATGATCCTAGATTAGGGAATTTG
ATGTCGGAATCACCAAATGGAATTATTAGAATTGGTCTGATTGGCTATCC
GATTGATTTAGGAGTTATTCGAAATGGTGGCAGGCCAGGAGCCGCTGGAG
GTCCAGAAGCTGTAAGGAATTTAATTAAAAAGAAAGGAGCAATTATAAAT
TCTGAATATGGAATTTCTTTGGAAGGAATCGAAATAAAAGATTTTGGTGA
TACAATTCTAAATGAGAATGATTTGAAAACTGCTCATTTGAATCATAAAA
ATATGGTTAAATCTATTTTAGATGATGGATATTTAGTGATAAGTATCGGA
GGAGGAAACGACCAAAGTTTTCCGAATTTTCTTGGTCTTTCAGAGTATCA
TGAAAAACATTTTTCAAAGTCTGGCGATAGCAACATGTTGATTGTAAATA
TTGATGCTCATCTCGACGTTAGGCCGTTGCTGGAAGGCGATGAACCTCAT
TCCGGTAGTCCTTTTCGGCAAATGTTGGAAACCAATACCAATTATTCTCT
AGATTTCGTAGAATTCGCATGTCAAGGAAGTCAGTGTTCTTCAAATCATG
TGGAATATGTGAAAATGAAAAAAGGGAATATAATTTGGTTAAAAGATCTT
CAAGGATCTTTGATCGATCATTCAAACAAAATAAATAGCACTGTCAAAAG
ATTTAGTCAATTAATAAATGATACAAAACACGATAATGTTTTCGTTTCAT
TCGATGTGGATAGCATACAGTCAAGTGATTGTCCGGGGGTAAGTTGCCCA
GCTGTCACTGGATTGACTGCCAACGAAGCTCTTTCTATCTGCTATGAAGC
GGGAAAATGTAAAAATGTTAGACTGTTCGATATCTCCGAATTCAATCCTA
GCATCGAATCCTATAGAACTGGAATCTTGATTGTCAACATGATATATTAC
TTCATGATGGGGGTAGCCTGCAGATCTTTATTGTAAATTTTATAACTTAA
AGTTGATTTTCTTTTCTGATAATGCAGACAAGAAATTTTAAAATTGAATG
ATTAAATTTGATTAATTATGGTTTCAAAA
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protein sequence of SMED30008978-orf-1

>SMED30008978-orf-1 ID=SMED30008978-orf-1|Name=SMED30008978-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=324bp
MNKFDDPRLGNLMSESPNGIIRIGLIGYPIDLGVIRNGGRPGAAGGPEAV
RNLIKKKGAIINSEYGISLEGIEIKDFGDTILNENDLKTAHLNHKNMVKS
ILDDGYLVISIGGGNDQSFPNFLGLSEYHEKHFSKSGDSNMLIVNIDAHL
DVRPLLEGDEPHSGSPFRQMLETNTNYSLDFVEFACQGSQCSSNHVEYVK
MKKGNIIWLKDLQGSLIDHSNKINSTVKRFSQLINDTKHDNVFVSFDVDS
IQSSDCPGVSCPAVTGLTANEALSICYEAGKCKNVRLFDISEFNPSIESY
RTGILIVNMIYYFMMGVACRSLL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR006035Ureohydrolase
IPR023696Ureohydrolase_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0046872metal ion binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:3.40.800.10coord: 1..321
e-value: 1.1E-84
score: 286.3
NoneNo IPR availablePANTHERPTHR11358ARGINASE/AGMATINASEcoord: 22..308
NoneNo IPR availablePANTHERPTHR11358:SF35coord: 22..308
NoneNo IPR availableCDDcd09988Formimidoylglutamasecoord: 24..313
e-value: 2.75825E-69
score: 214.69
IPR006035UreohydrolasePIRSFPIRSF036979Arginasecoord: 10..320
e-value: 4.9E-27
score: 92.4
IPR006035UreohydrolasePFAMPF00491Arginasecoord: 22..315
e-value: 7.7E-42
score: 143.7
IPR006035UreohydrolasePROSITEPS51409ARGINASE_2coord: 11..323
score: 33.821
IPR023696Ureohydrolase domain superfamilySUPERFAMILYSSF52768Arginase/deacetylasecoord: 22..318