Aldo-keto reductase

Overview
NameAldo-keto reductase
Smed IDSMED30008929
Length (bp)1115
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Aldo-keto reductase (SMED30008929) t-SNE clustered cells

Violin plots show distribution of expression levels for Aldo-keto reductase (SMED30008929) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Aldo-keto reductase (SMED30008929) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Aldo-keto reductase (SMED30008929) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30008929

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30008929SMESG000062723.1 dd_Smed_v4_9852_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30008929SMESG000062723.1 dd_Smed_v4_9852_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30008929SMESG000062723.1 dd_Smed_v4_9852_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
zeta neoblastSMED30008929SMESG000062723.1 dd_Smed_v4_9852_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1B10 (aldo-keto reductase family 1 member B10 [Source:HGNC Symbol;Acc:HGNC:382])

HSP 1 Score: 266.544 bits (680), Expect = 1.014e-86
Identity = 138/309 (44.66%), Postives = 199/309 (64.40%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            V+L +  +MPI GLGTW S  G+VK AV+ A++ GY+ IDCA+ Y NE E+GE ++  I    VKRE+LF+ SKLW +F    LV+   E+TL++LKLSYLD++LIH P  +K G +LFP  DK          ++ W+AME LVD G V+++GVSNF+  Q++ +L+    + KP  NQVE + Y   +KL+++C   G+ +TAYSPL G+P+RP    +    LEDPK+ E+A K+  TA Q+LI + I R ++ IPKSV+  R+ ENI+  + KL+DE+   + S N N R CN       ++YPF
Sbjct:    5 VELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPL-GSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPF 312          
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1B1 (aldo-keto reductase family 1 member B [Source:HGNC Symbol;Acc:HGNC:381])

HSP 1 Score: 251.906 bits (642), Expect = 5.362e-81
Identity = 140/310 (45.16%), Postives = 202/310 (65.16%), Query Frame = 1
Query:   94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEI-EDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            L +G +MPI GLGTW S PG+V  AV+ A+++GY+ IDCA  Y NE+E+G  ++  +    VKREELF+ SKLW ++H   LVK   ++TL +LKL YLDL+LIH P  +KPG  F   D+  + +  D ++++TW AME LVD G V++IG+SNFN  QV+ IL+    + KPA+NQ+E + Y   +KL+++C   G+ +TAYSPL G+P+RP    +    LEDP++  +A K+N T  Q+LI + + R LV IPKSV+  R+ EN K  + +L+ +D   L S N N R+C       HK+YPF E+
Sbjct:    7 LNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEE 315          
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1A1 (aldo-keto reductase family 1 member A1 [Source:HGNC Symbol;Acc:HGNC:380])

HSP 1 Score: 251.906 bits (642), Expect = 6.292e-81
Identity = 135/314 (42.99%), Postives = 197/314 (62.74%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGA------PNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYP 1002
             V L +G +MP+ GLGTW S+PG+VK AV+ AL++GY+ IDCA  Y NE EIGE L+  +  GK V REELFVTSKLWN+ H PE V+  L +TL +L+L YLDL+L+H P +++ G N FP         +     ETWKA+E LV  G V+++G+SNFN +Q+ +IL  + ++PA+ QVE + Y    +L+  C   G+++TAYSPLG +      P+ P+        LE+P VL LA+KY  +  QIL+ + + R ++ IPKS++  R+ +NIK  +   + E+ ++L++LN N R   P L    K  P
Sbjct:    5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVL-------LEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVP 311          
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1A1 (aldo-keto reductase family 1 member A1 [Source:HGNC Symbol;Acc:HGNC:380])

HSP 1 Score: 251.906 bits (642), Expect = 6.292e-81
Identity = 135/314 (42.99%), Postives = 197/314 (62.74%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGA------PNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYP 1002
             V L +G +MP+ GLGTW S+PG+VK AV+ AL++GY+ IDCA  Y NE EIGE L+  +  GK V REELFVTSKLWN+ H PE V+  L +TL +L+L YLDL+L+H P +++ G N FP         +     ETWKA+E LV  G V+++G+SNFN +Q+ +IL  + ++PA+ QVE + Y    +L+  C   G+++TAYSPLG +      P+ P+        LE+P VL LA+KY  +  QIL+ + + R ++ IPKS++  R+ +NIK  +   + E+ ++L++LN N R   P L    K  P
Sbjct:    5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVL-------LEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVP 311          
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1A1 (aldo-keto reductase family 1 member A1 [Source:HGNC Symbol;Acc:HGNC:380])

HSP 1 Score: 251.906 bits (642), Expect = 6.292e-81
Identity = 135/314 (42.99%), Postives = 197/314 (62.74%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGA------PNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYP 1002
             V L +G +MP+ GLGTW S+PG+VK AV+ AL++GY+ IDCA  Y NE EIGE L+  +  GK V REELFVTSKLWN+ H PE V+  L +TL +L+L YLDL+L+H P +++ G N FP         +     ETWKA+E LV  G V+++G+SNFN +Q+ +IL  + ++PA+ QVE + Y    +L+  C   G+++TAYSPLG +      P+ P+        LE+P VL LA+KY  +  QIL+ + + R ++ IPKS++  R+ +NIK  +   + E+ ++L++LN N R   P L    K  P
Sbjct:    5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVL-------LEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVP 311          
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: Y39G8B.1 (pep chromosome:WBcel235:II:13970584:13972970:-1 gene:WBGene00012722.1 transcript:Y39G8B.1b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y39G8B.1)

HSP 1 Score: 247.669 bits (631), Expect = 7.835e-80
Identity = 135/318 (42.45%), Postives = 188/318 (59.12%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLE------LAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-HKNYPFGED 1014
            ++KL SG+ +P  GLGTW SKPGEV  A++ A+  GY+ IDCA  Y N+ E+GE L+  +  GKVKREELF+TSK+WN+FH        ++  L +L+LSY+DL LIH P  Y  G  LFP  +  K    DVD +ETWKA E    +GK RSIG+SNF   Q+Q + D + +KPA  QVE++ YF   KL EFC + G+ +  YSPLG        G    R   DP VL       +A+ +  T  QI++ + +  GL  IPKSV+  R+ ENI  ++ +L+ E+ Q +D +N   R+ +P      HK + F E+
Sbjct:    4 SLKLNSGYSIPAIGLGTWQSKPGEVAAAIKTAVAAGYRHIDCAHVYQNQKEVGEALKEILDEGKVKREELFITSKVWNTFHSEAKAHENIDIILSDLQLSYVDLMLIHWPQGYAEGAELFPAGENGKMRYSDVDYLETWKAFEAAQKAGKCRSIGLSNFTHSQIQRVWDAAEVKPACLQVELHPYFTQVKLREFCKEKGIVVVGYSPLGNP------GSAFFRKDGDPNVLTNEVVAGIAKAHGKTPAQIILRWFVDSGLSAIPKSVTPQRIIENISVIDFQLSAEEIQAIDGVNRGWRLVDPSPRDGDHKYFGFNEE 315          
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: Y39G8B.1 (pep chromosome:WBcel235:II:13970789:13972970:-1 gene:WBGene00012722.1 transcript:Y39G8B.1a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y39G8B.1)

HSP 1 Score: 246.899 bits (629), Expect = 1.821e-79
Identity = 135/318 (42.45%), Postives = 188/318 (59.12%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLE------LAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCN-PELFKMHKNYPFGED 1014
            ++KL SG+ +P  GLGTW SKPGEV  A++ A+  GY+ IDCA  Y N+ E+GE L+  +  GKVKREELF+TSK+WN+FH        ++  L +L+LSY+DL LIH P  Y  G  LFP  +  K    DVD +ETWKA E    +GK RSIG+SNF   Q+Q + D + +KPA  QVE++ YF   KL EFC + G+ +  YSPLG        G    R   DP VL       +A+ +  T  QI++ + +  GL  IPKSV+  R+ EN+   + +LT E+  K+D +N N R+ +  +    H + PF E+
Sbjct:    4 SLKLNSGYSIPAIGLGTWQSKPGEVAAAIKTAVAAGYRHIDCAHVYQNQKEVGEALKEILDEGKVKREELFITSKVWNTFHSEAKAHENIDIILSDLQLSYVDLMLIHWPQGYAEGAELFPAGENGKMRYSDVDYLETWKAFEAAQKAGKCRSIGLSNFTHSQIQRVWDAAEVKPACLQVELHPYFTQVKLREFCKEKGIVVVGYSPLGNP------GSAFFRKDGDPNVLTNEVVAGIAKAHGKTPAQIILRWFVDSGLSAIPKSVTPQRISENLAVFDFQLTAEEISKIDGINKNWRIVDLSQRDGDHPHCPFLEE 315          
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: T08H10.1 (pep chromosome:WBcel235:V:4483459:4486543:1 gene:WBGene00020369.1 transcript:T08H10.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T08H10.1)

HSP 1 Score: 247.284 bits (630), Expect = 2.101e-79
Identity = 134/321 (41.74%), Postives = 198/321 (61.68%), Query Frame = 1
Query:   73 LNMLTVKLKSGHEMPIFGLGTWLSKP-GEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK--PGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPI--------EGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYP 1002
            + + ++ L +G ++P+FGLGTW  K   E+ +A+  AL+ GY+LID A  Y NE  IG+VL  YIS GK+KRE++FVTSKL  + H PE V   +E  L+ L+L Y+DL+LIH P  +K   G+  P  +  +  + ++  ++TW+A+E L   GK++++GVSNF+  Q+Q + D + +KPA  QVE +IY+P ++L   C K GV +TAY+PL G+P R          EG+    PL +P V +LA KY+ TA QILI +    G+ TIPKSVS  R+ ENI   + KL+DED   L+S+    R+   +    H  +P
Sbjct:    1 MTVDSIPLNTGAQLPLFGLGTWQVKDEAELTVALRAALDAGYRLIDTAHLYQNEHIIGKVLHEYISSGKLKREDIFVTSKLPFTAHAPEDVPKCVESQLKALQLEYIDLYLIHCPFPFKHQEGSFAPLMENGELAVTEIAHIDTWRALEKLYKEGKLKALGVSNFSCNQLQALYDAAEVKPANQQVECHIYWPQQELRALCKKLGVTVTAYAPL-GSPGRKAARPDGVWPEGD----PLLEPIVKQLAAKYHKTAAQILIRHLTQHGISTIPKSVSPDRIVENISTFDFKLSDEDMHTLNSIETRTRLFIADFAVKHPFFP 316          
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: C07D8.6 (pep chromosome:WBcel235:X:7341509:7342780:1 gene:WBGene00015565.1 transcript:C07D8.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C07D8.6)

HSP 1 Score: 200.675 bits (509), Expect = 1.552e-61
Identity = 113/320 (35.31%), Postives = 176/320 (55.00%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNR-----PIEGEKLR-----RPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            ++KL +G EMP+ GLGTW S P EV  AV+ A+  GY+LID A  Y NE  IG  ++  +  G VKREELF+T+K W     P  ++ GL E+L+ L+L Y+DL+L H P ++        ++     +EDV     W+  + +  +G  +++GVSN+N  Q+   L         +QVE+++YFP    V+FC K+ + +T+Y+ L G+P R     P  G+KL        L+D  VL LA+K + T  Q+L+ Y + RG   +PKS+   R++EN +  +  LT+ED  KL+    + R+   +    H    F  +
Sbjct:    7 SIKLSNGVEMPVIGLGTWQSSPAEVITAVKTAVKAGYRLIDTASVYQNEEAIGTAIKELLEEGVVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFNDDM----SEHIASPVEDV-----WRQFDAVYKAGLAKAVGVSNWNNDQISRALALGLTPVHNSQVELHLYFPQHDHVDFCKKHNISVTSYATL-GSPGRVNFTLPT-GQKLDWAPAPSDLQDQNVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTEEDIAKLEESKNSQRLFLQDFMTGHPEDAFAAE 315          
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: Y39G8B.2 (pep chromosome:WBcel235:II:13973690:13976221:-1 gene:WBGene00012723.1 transcript:Y39G8B.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y39G8B.2)

HSP 1 Score: 197.208 bits (500), Expect = 6.380e-60
Identity = 111/320 (34.69%), Postives = 178/320 (55.62%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK----PG--NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVL------ELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-HKNYPF 1005
            TV L SG+EMP+ G GTW          V +AL  GY+ ID A ++ N+ E+   ++ +    KV+REELF++SK+WN++H        ++E L   + +Y+DL +IH P  +     PG   L+P     K    DVD +ETWKA+E+   SGK+RSIG++NFNI QV+ +     IKPA+ QVE+N +   +++ +FC + G+ +TA+  L G P     G  L R  EDP +L       +A+ +  +  Q+L+ + I      + KS  + R+ +NI     +LT ++  ++ +LN++ R+ NP L    H  +P+
Sbjct:    6 TVTLNSGYEMPVIGYGTWQLPKNLAAERVRDALEAGYRHIDSALSFKNQEEVAAGIKDWCKIRKVRREELFLSSKIWNTYHSRNRCMQQIDEMLEIFETTYMDLIVIHWPFGWAEDEPPGERGLWPRGANGKMRYSDVDYLETWKALEDAHRSGKIRSIGLANFNIGQVEQVWTKGLIKPAVLQVEMNPFLDQEEIRQFCREKGIILTAFM-LTGNP-----GSALYRKHEDPNLLYNETLQSIAKGHGKSVVQVLVRWAIDLRTTALVKSSESKRIRQNINIFKFRLTSQEIARIKALNIDFRILNPLLGNYDHPYFPW 319          
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6083 (gene:FBgn0036183 transcript:FBtr0076137)

HSP 1 Score: 254.988 bits (650), Expect = 1.464e-82
Identity = 126/308 (40.91%), Postives = 193/308 (62.66%), Query Frame = 1
Query:   94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG--NLFPDA-DKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKAL-NIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            L +G  MP+ GLGTW S P  V  AV++A+++GY+  DCA  Y NE+++G  L   +  G V R+ELF+TSKLWN+ H+P+LV+   E ++RNL + YL+L+L+H P++YK G  NL+P   D  K   ED+D V+TW+AMENLVD G  ++IGVSNFN +Q+  +L  +++KP + Q+E + Y   K L+  C  N + +TAYS LG   + P E       L+ P +L +A+KY  TA Q+L+ +    G++ IP+SVS   + +N K + + +L  +D Q ++ L+ N R    +    H ++PF
Sbjct:    8 LSNGKNMPMLGLGTWRSPPEVVTQAVKDAIDIGYRHFDCAHIYGNEAQVGAALREKMDEGVVTRDELFITSKLWNTHHKPDLVRPACETSIRNLGVKYLNLYLMHWPMAYKSGSDNLYPTCPDTNKAAFEDIDYVDTWRAMENLVDEGLCQAIGVSNFNEQQMNRLLSVAKLKPVVLQIECHPYLSQKPLITLCYDNAIAVTAYSCLGSG-HTPYEKPGAYPLLQHPTILAIAEKYERTAAQVLLRFQTQSGIIVIPRSVSKQHMLDNFKRIWDFELAVDDIQAINELDCNGRFMTMKAAYGHPHHPF 314          
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6084 (gene:FBgn0086254 transcript:FBtr0331547)

HSP 1 Score: 249.21 bits (635), Expect = 2.775e-80
Identity = 153/313 (48.88%), Postives = 204/313 (65.18%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---MHKNYPFGED 1014
            VK  +G E+PI GLGTW S  G+V  AV+ A++ GY+ IDCA+ Y NE E+G+ +E  I  G VKRE+LF+TSKLWN+FHRP+LVK  LE TL +LKL YLDL+LIH P+ YK G +LFP     K     VD V+TWKAME LV+ G V+SIGVSNFN +Q++ +L+ + I P  NQ+E + Y   KKL++FC    + ITAYSPL G+PNRP         LE+ K+ E+A K   T GQILI Y + R  + IPKSV+  R+E N +  + +LT E+ + ++S   N R+    L K    HK YPF ++
Sbjct:    6 VKFNNGKEVPIIGLGTWGSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDITITAYSPL-GSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLV--PLLKDAGTHKYYPFHDE 315          
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6084 (gene:FBgn0086254 transcript:FBtr0076139)

HSP 1 Score: 247.284 bits (630), Expect = 1.248e-79
Identity = 152/311 (48.87%), Postives = 205/311 (65.92%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-HKNYPFGED 1014
            VK  +G E+PI GLGTW S  G+V  AV+ A++ GY+ IDCA+ Y NE E+G+ +E  I  G VKRE+LF+TSKLWN+FHRP+LVK  LE TL +LKL YLDL+LIH P+ YK G +LFP     K     VD V+TWKAME LV+ G V+SIGVSNFN +Q++ +L+ + I P  NQ+E + Y   KKL++FC    + ITAYSPL G+PNRP         LE+ K+ E+A K   T GQILI Y + R  + IPKSV+  R+E N +  + +LT E+ + ++S   N R+  P L +  H ++PF +D
Sbjct:    6 VKFNNGKEVPIIGLGTWGSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDITITAYSPL-GSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLV-PLLNQYGHPHHPFEKD 314          
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6084 (gene:FBgn0086254 transcript:FBtr0076138)

HSP 1 Score: 241.891 bits (616), Expect = 5.656e-77
Identity = 149/308 (48.38%), Postives = 202/308 (65.58%), Query Frame = 1
Query:  103 GHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---MHKNYPFGED 1014
            G+E+P+ GLGT+ S  G+V  AV+ A++ GY+ IDCA+ Y NE E+G+ +E  I  G VKRE+LF+TSKLWN+FHRP+LVK  LE TL +LKL YLDL+LIH P+ YK G +LFP     K     VD V+TWKAME LV+ G V+SIGVSNFN +Q++ +L+ + I P  NQ+E + Y   KKL++FC    + ITAYSPL G+PNRP         LE+ K+ E+A K   T GQILI Y + R  + IPKSV+  R+E N +  + +LT E+ + ++S   N R+    L K    HK YPF ++
Sbjct:   45 GNEIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDITITAYSPL-GSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLV--PLLKDAGTHKYYPFHDE 349          
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6084 (gene:FBgn0086254 transcript:FBtr0331546)

HSP 1 Score: 239.965 bits (611), Expect = 2.615e-76
Identity = 148/306 (48.37%), Postives = 203/306 (66.34%), Query Frame = 1
Query:  103 GHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-HKNYPFGED 1014
            G+E+P+ GLGT+ S  G+V  AV+ A++ GY+ IDCA+ Y NE E+G+ +E  I  G VKRE+LF+TSKLWN+FHRP+LVK  LE TL +LKL YLDL+LIH P+ YK G +LFP     K     VD V+TWKAME LV+ G V+SIGVSNFN +Q++ +L+ + I P  NQ+E + Y   KKL++FC    + ITAYSPL G+PNRP         LE+ K+ E+A K   T GQILI Y + R  + IPKSV+  R+E N +  + +LT E+ + ++S   N R+  P L +  H ++PF +D
Sbjct:   45 GNEIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDITITAYSPL-GSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLV-PLLNQYGHPHHPFEKD 348          
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1a1a (aldo-keto reductase family 1, member A1a (aldehyde reductase) [Source:NCBI gene;Acc:445326])

HSP 1 Score: 272.707 bits (696), Expect = 2.518e-89
Identity = 143/322 (44.41%), Postives = 204/322 (63.35%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVL-ERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRP--IEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---------MHKNYPFGE 1011
            T+ L +G  MP  GLGTW S PG+VK AV  AL+ GY+ IDCA AY NE E+GE L ER   G  ++R+++FVTSKLWN+ H P+ V+     +L +L+LSYLDL+LIH P+++  G+ L P       + +D    +TW AME LVD G  ++IG+SNFN KQ+ +IL  ++ KP +NQVE + Y    +LV  C    + +TAYSPL G+P+RP    GE L   L+DP+V+ +A+ YN T  Q++I + I RG+V IPKSV+  R+++NI+  + KL+DED + ++S N N R   P + K          H ++PF E
Sbjct:    4 TITLSTGQRMPTVGLGTWKSAPGQVKQAVLAALDCGYRHIDCAAAYSNEREVGEALTERLGPGKSLRRDDIFVTSKLWNTKHHPDDVEEACRRSLSDLRLSYLDLYLIHWPMAFGRGDELIPRHPDGTIQYDDTHYRDTWAAMEKLVDQGLAKAIGLSNFNAKQIDDILSIAKHKPVVNQVECHPYLVQAELVSHCWSRNLTVTAYSPL-GSPDRPWVTPGEALL--LDDPRVVGIAKSYNKTPAQVIIRWHIQRGVVCIPKSVTPSRIKQNIEVFDFKLSDEDMRLIESFNRNERFIIPTVIKDGQKIWRDAKHPHFPFIE 322          
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1a1a (aldo-keto reductase family 1, member A1a (aldehyde reductase) [Source:NCBI gene;Acc:445326])

HSP 1 Score: 272.322 bits (695), Expect = 3.602e-89
Identity = 143/322 (44.41%), Postives = 204/322 (63.35%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVL-ERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRP--IEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---------MHKNYPFGE 1011
            T+ L +G  MP  GLGTW S PG+VK AV  AL+ GY+ IDCA AY NE E+GE L ER   G  ++R+++FVTSKLWN+ H P+ V+     +L +L+LSYLDL+LIH P+++  G+ L P       + +D    +TW AME LVD G  ++IG+SNFN KQ+ +IL  ++ KP +NQVE + Y    +LV  C    + +TAYSPL G+P+RP    GE L   L+DP+V+ +A+ YN T  Q++I + I RG+V IPKSV+  R+++NI+  + KL+DED + ++S N N R   P + K          H ++PF E
Sbjct:    4 TITLSTGQRMPTVGLGTWKSAPGQVKQAVLAALDCGYRHIDCAAAYSNEREVGEALTERLGPGKSLRRDDIFVTSKLWNTKHHPDDVEEACRRSLSDLRLSYLDLYLIHWPMAFGRGDELIPRHPDGTIQYDDTHYRDTWAAMEKLVDQGLAKAIGLSNFNAKQIDDILSIAKHKPVVNQVECHPYLVQAELVSHCWSRNLTVTAYSPL-GSPDRPWVTPGEALL--LDDPRVVGIAKSYNKTPAQVIIRWHIQRGVVCIPKSVTPSRIKQNIEVFDFKLSDEDMRLIESFNRNERFIIPTVIKDGQKIWRDANHPHFPFIE 322          
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1b1.1 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-040625-7])

HSP 1 Score: 263.077 bits (671), Expect = 1.313e-85
Identity = 141/313 (45.05%), Postives = 201/313 (64.22%), Query Frame = 1
Query:   79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIED-VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            M +V L +G +MPI GLGTW S PGEV  AV++A+  GY+ ID A  Y NE+E+G+ +   I+ G VKR++LF+ SKLW +FH   LV+   E+TL +LKL Y+DL+L+H P+  KPG +LFP  DK    I D  + +ETW+AME LVD+G V++IG+SNFN  Q++ IL+    + KPA NQ+E + Y   +KL+ +C   G+ +TAYSPL G+PNRP         LEDPK+  +A K+  T  Q+LI + I R +V IPKSV+  R++EN +  + +L+ E+   + S N N R    E    HK++P 
Sbjct:    1 MTSVTLNNGAKMPIVGLGTWRSPPGEVTEAVKSAILSGYRHIDGAHVYENENEVGDGICAMINQGVVKRKDLFIVSKLWCTFHEKHLVRGACEKTLSDLKLDYVDLYLMHFPMGTKPGKDLFP-LDKDGHVIPDNSNFLETWEAMEELVDAGLVKAIGISNFNRDQIEAILNKPGLKYKPANNQIECHPYLTQEKLINYCQSKGITVTAYSPL-GSPNRPWAQADEPSLLEDPKIKAIADKHGKTTAQVLIHFHIQRNVVVIPKSVTPSRIKENFEVFDFELSKEEMNTILSFNRNFRAFGLEWASKHKDFPL 311          
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1b1.1 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-040625-7])

HSP 1 Score: 256.914 bits (655), Expect = 2.091e-83
Identity = 137/298 (45.97%), Postives = 195/298 (65.44%), Query Frame = 1
Query:   79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIED-VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIR 960
            M +V L +G +MPI GLGTW S PGEV  AV++A+  GY+ ID A  Y NE+E+G+ +   I+ G VKR++LF+ SKLW +FH   LV+   E+TL +LKL Y+DL+L+H P+  KPG +LFP  DK    I D  + +ETW+AME LVD+G V++IG+SNFN  Q++ IL+    + KPA NQ+E + Y   +KL+ +C   G+ +TAYSPL G+PNRP         LEDPK+  +A K+  T  Q+LI + I R +V IPKSV+  R++EN +  + +L+ E+   + S N N R
Sbjct:    1 MTSVTLNNGAKMPIVGLGTWRSPPGEVTEAVKSAILSGYRHIDGAHVYENENEVGDGICAMINQGVVKRKDLFIVSKLWCTFHEKHLVRGACEKTLSDLKLDYVDLYLMHFPMGTKPGKDLFP-LDKDGHVIPDNSNFLETWEAMEELVDAGLVKAIGISNFNRDQIEAILNKPGLKYKPANNQIECHPYLTQEKLINYCQSKGITVTAYSPL-GSPNRPWAQADEPSLLEDPKIKAIADKHGKTTAQVLIHFHIQRNVVVIPKSVTPSRIKENFEVFDFELSKEEMNTILSFNRNFR 296          
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1b1.2 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-041210-132])

HSP 1 Score: 248.825 bits (634), Expect = 1.267e-79
Identity = 136/310 (43.87%), Postives = 200/310 (64.52%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            +VKL +G +MPI GLGTW S PG+V  AV+ A+  GY+ ID A  Y NE+E+GE ++  I  G VKREELFV SKLW +FH   LVK   ++TL +L L YLDL+LIH P+ +K G+  FP   +     +D   ++TW+AME LVD+G V++IG+SNFN +Q++ IL+    + KPA NQVE + Y    KL+ +C   G+ +TAYSPL G+P+RP    +    L+DP +  +A+K+  T  Q+LI + I R ++ IPKS++  R++EN +  + +L+++D + + S N N R C       H++YPF
Sbjct:   32 SVKLNTGADMPILGLGTWKSPPGKVTEAVKAAIAAGYRHIDGAAVYNNETEVGEGIKAMIKDGVVKREELFVVSKLWCTFHEKALVKGACQKTLSDLNLDYLDLYLIHWPMGFKSGSEQFPLDSEGLTIGDDSSFLDTWEAMEELVDAGLVKAIGISNFNREQIEAILNKPGLKYKPANNQVECHPYLTQDKLISYCQSKGITVTAYSPL-GSPDRPWAKPEDPSLLDDPNIKAIAEKHKKTTAQVLIRFQIQRNVIVIPKSITPQRIQENFQVFDFELSEQDMKTILSFNRNFRACPMHWGVKHRDYPF 340          
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: akr1b1 (aldo-keto reductase family 1, member B1 (aldose reductase) [Source:NCBI gene;Acc:496546])

HSP 1 Score: 254.988 bits (650), Expect = 3.038e-82
Identity = 137/309 (44.34%), Postives = 208/309 (67.31%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            V+L +G +MPI GLGTW S+PG+V  AV  A+ +GY+ +DCA+ Y NE+E+GE +++ I  G VKRE+LFV SKLW++FH   +VK   ++TL +LKL YLDL+L+H P  ++ G+ LFP  ++      +   ++TW+ ME LVD+G V++IG+SNFN +Q++ +L+   +  KPA++Q E + Y   KKL++ C   G+ +TAYSPL G+P+RP    +    LE+PK+ E+A+KYN T+ Q+LI + I R +V IPKSV+  R+EEN +  + +L+ ED + + S     R+C     K HK+YPF
Sbjct:    7 VQLYTGAQMPIVGLGTWKSEPGKVTAAVAKAIEVGYRHLDCAYVYQNENEVGEGIQQKIKEGLVKREDLFVVSKLWSTFHDKSMVKGACQKTLSDLKLDYLDLYLVHWPTGFQAGDALFPLDNEGCVIHSNTHFLDTWEGMEELVDAGLVKAIGISNFNREQIEQLLNKPGLKHKPAVHQFECHPYLTQKKLIDLCQSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEEPKIKEIAKKYNKTSAQVLIRFHIQRNVVVIPKSVTPARIEENFQVFDFELSPEDTEAIFSFERGWRVCALSSAKKHKDYPF 314          
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: akr1c2 (aldo-keto reductase family 1, member C2 [Source:NCBI gene;Acc:779650])

HSP 1 Score: 239.58 bits (610), Expect = 3.812e-76
Identity = 127/315 (40.32%), Postives = 189/315 (60.00%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENA---LNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKP-GNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            V L  G+ MP+ G GT+  +     LA E A   +++GY+ ID A+ Y NE+E+G  +   I+ G VKRE+LF T KLW+SFH PE V+ G E++L++L+L Y+DLF+IH P+ +KP  N FP  +  K    + DL +TWKAME L D G V+SIGVSNFN +Q++ IL     + KP  NQVE +IY    KL+EFC    + +  YS LG + +     +     LEDP +  +A+K N T  Q+ + Y + RG+V + KS +  R+++N +  + +L  E+ + LD +N N+R  + +    H  YPF +D
Sbjct:    9 VLLNDGNRMPVIGYGTYAPQNVPKHLAEEGAKVAIDVGYRHIDSAFMYLNEAEVGRAINAKIADGTVKREDLFYTGKLWSSFHTPERVRQGFEKSLKDLQLDYMDLFIIHLPVEFKPEDNPFPVDENGKFLYHNTDLRDTWKAMEALKDEGLVKSIGVSNFNKRQLELILSMPGLKYKPVCNQVECHIYLNQSKLLEFCKSKDIVLVGYSVLGSSRDEQWIDQNSPVVLEDPVLNAIAKKLNRTPAQVAMRYLLQRGVVILAKSFTPARIQQNFQIFDFQLNAEEMKTLDGVNKNLRYLDLKQLADHPKYPFADD 323          
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: tm4sf5 (transmembrane 4 L six family member 5 [Source:Xenbase;Acc:XB-GENE-969431])

HSP 1 Score: 238.424 bits (607), Expect = 8.473e-76
Identity = 128/317 (40.38%), Postives = 194/317 (61.20%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEV--KLAVEN---ALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            V L  GH+MP+ G GT++  PG++   LA E    A+++GY+ ID A+ Y NE E+G  +   I+ G VKRE++F T KLW +FH PE V+V L+++L++L+L YLDLF+IH P+ +KPG +  P  +  K    + DL +TWKA+E   D+G VRSIGVSNFN KQ++ IL+    + KP  NQVE +IY    KL+EFC    + + AY  LG   ++    +     LE+  +  +A+K+N T   + + Y + RG+V + KS +  R++EN K  N +L DED + +D +N ++R  +   +  H  YPF E+
Sbjct:    9 VVLNDGHKMPVLGFGTFV--PGKLPKSLAEEGTKVAIDVGYRHIDSAFFYGNEVEVGRAIRAKIADGTVKREDVFYTGKLWCTFHTPERVRVCLDKSLKDLQLDYLDLFIIHIPVEFKPGDDPLPVDENGKCIFHNTDLRDTWKALEKCKDAGLVRSIGVSNFNHKQLELILNMPGLKYKPVCNQVECHIYLNQSKLLEFCKSKDIVLVAYGVLGSTRDKKWIDQSTPFLLENAVLNAIAKKHNCTPAHVAMRYLLQRGVVVLAKSFNPARIKENFKVFNFQLDDEDMKTIDEINRDLRYLDITAWSDHPKYPFHEE 323          
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: akr1c8p (aldo-keto reductase family 1, member C8, pseudogene [Source:NCBI gene;Acc:448368])

HSP 1 Score: 237.269 bits (604), Expect = 2.963e-75
Identity = 123/316 (38.92%), Postives = 190/316 (60.13%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVEN---ALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
             ++L  GH+MP+ G GT+  +     LA E    A+++GY+ ID A+ Y NE E+G  +   I+ G VKRE++F T KLW++FH PE V+  LE++L +L+L Y+DLF+IH P+  KPG +  P  +  K    + D+ +TWKA+E   D+G VRSIGVSNFN KQ++ IL+    + KP  NQVE ++Y    KL+EFC    + + A+  LG + +       L   LEDP +  +A+K+N T  Q+ + Y + RG+V + KS +  R+++N +  N+ L  ED + +D +N N+R     ++  H  YPF E+
Sbjct:    8 CIELNDGHKMPVLGFGTYAPQKFPKSLAEEGTKVAIDVGYRHIDSAFFYGNEVEVGRAIRAKIADGTVKREDVFYTGKLWSTFHTPERVRPALEKSLNDLQLDYMDLFIIHIPVELKPGDDPLPLDENGKFIYHNTDIRDTWKALEKCKDAGLVRSIGVSNFNHKQLELILNMPGLKYKPVCNQVECHVYLNQSKLLEFCKSKDIVLVAFGVLGSSRDESWIDPNLPVLLEDPVLNAIAKKHNCTPAQVAMRYLLQRGVVVLVKSFTPARIQQNFQVFNVHLDAEDMRNVDGINRNLRYDYAPMWSDHPKYPFHEE 323          
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: nudt2 (nudix hydrolase 2 [Source:Xenbase;Acc:XB-GENE-1008721])

HSP 1 Score: 236.113 bits (601), Expect = 3.013e-75
Identity = 120/285 (42.11%), Postives = 183/285 (64.21%), Query Frame = 1
Query:  178 ALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPN-RPIEGEKLRRP--LEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            A+++GY+ IDCA+ Y +E E+G  +   I+ G VKRE++F T KLW++FH PE V+V LE++L++L+L Y+DLF+IH P+ +KPG +LFP  +  K    + DL +TWKA+E   D+G VRSIGVSNFN KQ++ IL+    + KP  NQVE ++Y    KL+EFC    + +  YS LG + + R IE      P  LEDP + E+A+K+N T  Q+ + Y + RG+V + KS +  R+++N +  + +L  ED + +D LN N+R  +   +  H  YP+ E+
Sbjct:   15 AIDVGYRHIDCAFIYGSEVEVGRAIGAKIADGTVKREDVFYTGKLWSTFHTPERVRVCLEKSLKDLQLDYMDLFIIHNPMEFKPGDDLFPADENGKFIYHNTDLRDTWKALEKCKDAGLVRSIGVSNFNHKQLELILNMPGLKYKPVCNQVECHVYLNQSKLLEFCKSKDIVLVGYSVLGSSRDERWIEASA---PVLLEDPTLTEIAKKHNRTPAQVAMRYHLQRGVVVLAKSFTPARIQQNFQVFDFQLDAEDMRSIDGLNRNMRYIDTSRWSDHPKYPYSEE 296          
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1b3 (aldo-keto reductase family 1, member B3 (aldose reductase) [Source:MGI Symbol;Acc:MGI:1353494])

HSP 1 Score: 258.07 bits (658), Expect = 1.032e-83
Identity = 142/309 (45.95%), Postives = 200/309 (64.72%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEI-EDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            ++L +G +MP  GLGTW S PG+V  AV+ A++LGY+ IDCA  Y NE E+G  L+  +    VKR++LF+ SKLW +FH   +VK   ++TL +L+L YLDL+LIH P  +KPG  +   D   + I  D D V+TW AME LVD G V++IGVSNFN  Q++ IL+    + KPA+NQ+E + Y   +KL+E+C   G+ +TAYSPL G+P+RP    +    LEDP++  +A KYN T  Q+LI + I R LV IPKSV+ +R+ EN+K  + +++ ED   L S N N R+C       HK+YPF
Sbjct:    5 LELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYPF 312          
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1a1 (aldo-keto reductase family 1, member A1 (aldehyde reductase) [Source:MGI Symbol;Acc:MGI:1929955])

HSP 1 Score: 253.062 bits (645), Expect = 1.686e-81
Identity = 129/304 (42.43%), Postives = 196/304 (64.47%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGA------PNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNP 972
            +V L +G +MP+ GLGTW S+PG+VK A+++AL+ GY+ IDCA  Y NE+EIGE L+  +  GK V REELFVTSKLWN+ H PE V+  L +TL +L+L YLDL+L+H P +++ G N FP         +     ETWKA+E LV  G V+++G+SNFN +Q+ ++L  + ++PA+ QVE + Y    +L+  C   G+++TAYSPLG +      P+ P+        LE+P VL LA+K+  +  QIL+ + + R ++ IPKS++  R+ +NI+  +   + E+ ++LD+LN N R   P
Sbjct:    5 SVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVL-------LEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301          
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1b8 (aldo-keto reductase family 1, member B8 [Source:MGI Symbol;Acc:MGI:107673])

HSP 1 Score: 245.743 bits (626), Expect = 9.248e-79
Identity = 137/310 (44.19%), Postives = 201/310 (64.84%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMC-NPELFKMHKNYPF 1005
            V+L +  +MPI GLGTW S P +VK AV+ A++ GY+ IDCA+AYCNE+E+GE ++  I    V+RE+LF+ SKLW +    +L+K   ++TL +LKL YLDL+LIH P   +PG  LFP  D+ +        +E W+ ME LVD G V+++GVSNFN  Q++ +L+   +  KP  NQVE + Y   +KL+++C   G+ +TAYSPL G+P+RP    +    LEDPK+ E+A K+  T+ Q+LI + I R +V IPKSV+  R++ENI+  + +L+DE+   + S N N R C  PE   M + YP+
Sbjct:    5 VELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQEKIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGISVTAYSPL-GSPDRPSAKPEDPSLLEDPKIKEIAAKHEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACLLPETVNM-EEYPY 312          
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1b10 (aldo-keto reductase family 1, member B10 (aldose reductase) [Source:MGI Symbol;Acc:MGI:1915111])

HSP 1 Score: 243.432 bits (620), Expect = 5.563e-78
Identity = 137/309 (44.34%), Postives = 198/309 (64.08%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLF-PDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            V L +G +MPI GLGTW S P +V+ AV+ A++ GY+ IDCA+ Y NESE+GE ++  I    VKRE+LF+ SKLW++F    LVK   + TL +LKL YLDL+LIH P  ++ GN+F P  DK          ++ W+AME LVD G V+++GVSNFN  Q++ +L+   +  KP  NQVE + Y   +KL+++C   G+ ITAYSPL G+P+RP    +    LE PK+ E+A K+  TA Q+LI + I R +V IPKSV+  R++ENI+  + +L++ED   + S N N R C       ++++PF
Sbjct:    5 VTLLTGAKMPIVGLGTWKSPPAKVREAVKVAIDAGYRHIDCAYVYQNESEVGEAIQEKIQEKAVKREDLFIVSKLWSTFFEKSLVKKAFQNTLSDLKLDYLDLYLIHWPQGFQSGNVFLPTDDKGSILSSKYTFLDAWEAMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGITITAYSPL-GSPDRPSAKPEDPLLLEIPKIKEIAAKHKRTAAQVLIRFHIERNVVVIPKSVTPSRIQENIQVFDFQLSEEDMAAILSFNRNWRACGLFAASHNEDFPF 312          
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1c6 (aldo-keto reductase family 1, member C6 [Source:MGI Symbol;Acc:MGI:1933427])

HSP 1 Score: 243.817 bits (621), Expect = 6.461e-78
Identity = 131/318 (41.19%), Postives = 193/318 (60.69%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEV-----KLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            TV+L  GH +PI G GT+   P EV       A + A++ G++ ID A  Y NE E+G  +   I+ G VKRE++F TSK+W +FHRPELV+V LE++L+ L+L Y+DL+LIH P++ KPG N  P  +  K   + VD+ +TW+AME   D+G  +SIGVSNFN +Q++ IL     + KP  NQVE + Y    KL++FC    + + AYS LG    +    +     L++P +  +A+KYN T   I + Y + RG+V + KS S  R++EN++    +LT ED + LD LN NIR  +   FK H ++PF ++
Sbjct:    7 TVRLSDGHFIPILGFGTY--APQEVPKSKATEATKIAIDAGFRHIDSASMYQNEKEVGLAIRSKIADGTVKREDIFYTSKVWCTFHRPELVRVCLEQSLKQLQLDYVDLYLIHFPMAMKPGENYLPKDENGKLIYDAVDICDTWEAMEKCKDAGLAKSIGVSNFNRRQLEKILKKPGLKYKPVCNQVECHPYLNQGKLLDFCRSKDIVLVAYSALGSHREKQWVDQSSPVLLDNPVLGSMAKKYNRTPALIALRYQLQRGVVVLAKSFSEKRIKENMQVFEFQLTSEDMKVLDDLNKNIRYISGSSFKDHPDFPFWDE 322          
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|Q6AZW2|A1A1A_DANRE (Aldo-keto reductase family 1 member A1-A OS=Danio rerio OX=7955 GN=akr1a1a PE=2 SV=2)

HSP 1 Score: 272.707 bits (696), Expect = 1.901e-88
Identity = 143/322 (44.41%), Postives = 204/322 (63.35%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVL-ERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRP--IEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---------MHKNYPFGE 1011
            T+ L +G  MP  GLGTW S PG+VK AV  AL+ GY+ IDCA AY NE E+GE L ER   G  ++R+++FVTSKLWN+ H P+ V+     +L +L+LSYLDL+LIH P+++  G+ L P       + +D    +TW AME LVD G  ++IG+SNFN KQ+ +IL  ++ KP +NQVE + Y    +LV  C    + +TAYSPL G+P+RP    GE L   L+DP+V+ +A+ YN T  Q++I + I RG+V IPKSV+  R+++NI+  + KL+DED + ++S N N R   P + K          H ++PF E
Sbjct:    4 TITLSTGQRMPTVGLGTWKSAPGQVKQAVLAALDCGYRHIDCAAAYSNEREVGEALTERLGPGKSLRRDDIFVTSKLWNTKHHPDDVEEACRRSLSDLRLSYLDLYLIHWPMAFGRGDELIPRHPDGTIQYDDTHYRDTWAAMEKLVDQGLAKAIGLSNFNAKQIDDILSIAKHKPVVNQVECHPYLVQAELVSHCWSRNLTVTAYSPL-GSPDRPWVTPGEALL--LDDPRVVGIAKSYNKTPAQVIIRWHIQRGVVCIPKSVTPSRIKQNIEVFDFKLSDEDMRLIESFNRNERFIIPTVIKDGQKIWRDAKHPHFPFIE 322          
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|O60218|AK1BA_HUMAN (Aldo-keto reductase family 1 member B10 OS=Homo sapiens OX=9606 GN=AKR1B10 PE=1 SV=2)

HSP 1 Score: 266.544 bits (680), Expect = 4.869e-86
Identity = 138/309 (44.66%), Postives = 199/309 (64.40%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            V+L +  +MPI GLGTW S  G+VK AV+ A++ GY+ IDCA+ Y NE E+GE ++  I    VKRE+LF+ SKLW +F    LV+   E+TL++LKLSYLD++LIH P  +K G +LFP  DK          ++ W+AME LVD G V+++GVSNF+  Q++ +L+    + KP  NQVE + Y   +KL+++C   G+ +TAYSPL G+P+RP    +    LEDPK+ E+A K+  TA Q+LI + I R ++ IPKSV+  R+ ENI+  + KL+DE+   + S N N R CN       ++YPF
Sbjct:    5 VELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPL-GSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPF 312          
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|P07943|ALDR_RAT (Aldo-keto reductase family 1 member B1 OS=Rattus norvegicus OX=10116 GN=Akr1b1 PE=1 SV=3)

HSP 1 Score: 258.455 bits (659), Expect = 6.548e-83
Identity = 143/309 (46.28%), Postives = 200/309 (64.72%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEI-EDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            ++L +G +MP  GLGTW S PG+V  AV+ A+++GY+ IDCA  Y NE E+G  L+  +    VKR++LF+ SKLW +FH   +VK   ++TL +L+L YLDL+LIH P  +KPG  +   D   + I  D D V+TW AME LVD G V++IGVSNFN  Q++ IL+    + KPA+NQ+E + Y   +KL+E+C   G+ +TAYSPL G+P+RP    +    LEDP++ E+A KYN T  Q+LI + I R LV IPKSV+  R+ EN K  + +L++ED   L S N N R+C       HK+YPF
Sbjct:    5 LELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPF 312          
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|P45376|ALDR_MOUSE (Aldo-keto reductase family 1 member B1 OS=Mus musculus OX=10090 GN=Akr1b1 PE=1 SV=3)

HSP 1 Score: 258.07 bits (658), Expect = 7.218e-83
Identity = 142/309 (45.95%), Postives = 200/309 (64.72%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEI-EDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            ++L +G +MP  GLGTW S PG+V  AV+ A++LGY+ IDCA  Y NE E+G  L+  +    VKR++LF+ SKLW +FH   +VK   ++TL +L+L YLDL+LIH P  +KPG  +   D   + I  D D V+TW AME LVD G V++IGVSNFN  Q++ IL+    + KPA+NQ+E + Y   +KL+E+C   G+ +TAYSPL G+P+RP    +    LEDP++  +A KYN T  Q+LI + I R LV IPKSV+ +R+ EN+K  + +++ ED   L S N N R+C       HK+YPF
Sbjct:    5 LELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYPF 312          
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|P80276|ALDR_PIG (Aldo-keto reductase family 1 member B1 OS=Sus scrofa OX=9823 GN=AKR1B1 PE=1 SV=2)

HSP 1 Score: 256.529 bits (654), Expect = 2.886e-82
Identity = 151/313 (48.24%), Postives = 204/313 (65.18%), Query Frame = 1
Query:   94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFP---DADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            L +G +MPI GLGTW S PG+V  AV+ A++LGY+ IDCA  Y NE+E+G  L+  + G  VKRE+LF+ SKLW + H   LVK   + TLR+LKL YLDL+LIH P  +KPG + FP   D +   DE    D VETW+AME LVD G V++IGVSNFN  QV+ IL+    + KPA+NQ+EV+ Y   +KL+E+C   G+ +TAYSPL G+P+RP    +    LEDP++  +A KYN T  Q+LI + + R L+ IPKSV+  R+ EN +  + +L+ ED   L S N N R+C       HK+YPF E+
Sbjct:    7 LYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLDGDGNVVPDE---SDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCALMSCASHKDYPFHEE 315          
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A026WTR5 (Aldo-keto reductase family 1 member B10 OS=Ooceraea biroi OX=2015173 GN=X777_15999 PE=4 SV=1)

HSP 1 Score: 317.39 bits (812), Expect = 1.744e-103
Identity = 153/313 (48.88%), Postives = 216/313 (69.01%), Query Frame = 1
Query:   73 LNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFG 1008
            LN   VK  +G+E+P+FGLGTW SKPGEV  AV++A+++GY+ +DCA+ Y NE E+G  ++  I+ G VKRE+LF+TSKLWN+FH+P+LV+  L++TL N  LSY+DL+LIH P+ YK G +LFP   +    + DVD V+TWKAMEN++  G  ++IGVSNFN +Q+  +L+++++KP  NQVE + Y   KKL +FC K  + ITAYSPL G+P+RP       + LED K++ELAQKYN T  Q+LI Y + RG + IPKSV+  R+ +N +  + KL+ ED   +DS + N R+C          YPFG
Sbjct:    3 LNAPKVKFYNGNEIPVFGLGTWKSKPGEVTQAVKDAIDIGYRHLDCAYVYGNEKEVGMAIQEKIADGTVKREDLFITSKLWNTFHKPDLVESALKQTLTNFGLSYIDLYLIHWPVGYKDGESLFPTTPEGTTALSDVDYVDTWKAMENVLSKGLTKNIGVSNFNSEQITRLLENAKVKPVTNQVECHPYLTQKKLSDFCKKKDILITAYSPL-GSPDRPWAKPDDPKLLEDTKLIELAQKYNKTPAQVLIRYQLDRGHIVIPKSVTKSRIAQNSQVFDFKLSPEDIAYIDSFDCNGRICPLLGADASPYYPFG 314          
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A1J1IMG6 (CLUMA_CG013551, isoform A OS=Clunio marinus OX=568069 GN=CLUMA_CG013551 PE=4 SV=1)

HSP 1 Score: 312.383 bits (799), Expect = 1.596e-101
Identity = 155/310 (50.00%), Postives = 213/310 (68.71%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG--NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMC--NPELFKMHKNYPF 1005
            V LK+G ++P  GLGTW S PG+V+ AV++A+++GY+ IDCA+ Y NE+E+G  +   I+ GKVKREELF+TSKLWN+FH P+ VK  LE+TL+NLK  YLDL+LIH P+ YK    +LFP  +  +    + D V+TWKAMENLVDSG ++SIG+SNFN KQ++ +L+ +RI P MNQVE + Y   KKL+E C   G+ ITAYSPL G+P+RP         ++DPK+LE+++KYN +A QILI Y + RG + IPKSV+  R+  N    N +L D D   +D+ N+  R C  N +    H +YPF
Sbjct:    6 VTLKNGQKIPALGLGTWKSPPGQVEQAVKDAIDVGYRHIDCAFVYGNENEVGNAISEKIADGKVKREELFLTSKLWNTFHNPKDVKPALEKTLKNLKTDYLDLYLIHWPMGYKEAGDDLFPKNENGELLFSNDDYVDTWKAMENLVDSGLIKSIGLSNFNSKQIERVLEIARIPPVMNQVECHPYLTQKKLMELCRSKGIHITAYSPL-GSPDRPWAKPGDTELMQDPKLLEISKKYNKSAAQILIKYQLQRGNIVIPKSVTKSRIMSNFDVFNFELNDGDIAAIDAFNMGGRFCPLNFDGLPQHLHYPF 314          
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A067QJF4 (Aldo-keto reductase family 1 member B10 OS=Zootermopsis nevadensis OX=136037 GN=L798_02632 PE=4 SV=1)

HSP 1 Score: 311.997 bits (798), Expect = 2.212e-101
Identity = 161/319 (50.47%), Postives = 217/319 (68.03%), Query Frame = 1
Query:   52 ICSKIFHLNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKP-GNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            + SKI  L   TVK  +G E PIFGLGTW SKPGEV  AV++A+++GY+ IDCA  Y NE E+G  ++  I    VKRE+LF+TSKLWN+FHR +LV   +++TL +L L +LDL+LIH P++Y+  G+LFP+ D  K    D D V+TWKAME LV  G  +SIGVSNFN +Q++ IL  + IKP  NQ+E + Y   KKL+EFC    V ITAYSPL G+P+RP       + L+DPKV E+A++Y  T  QILI Y + RG +TIPKSV+  R+EEN +  + +L++ED   +DS + N R+C+    K HK+YPF
Sbjct:    1 MVSKI--LKTPTVKFNNGIEFPIFGLGTWKSKPGEVTQAVKDAIDIGYRHIDCAHVYGNEPEVGAAIKAKIDEKVVKREDLFITSKLWNTFHRTDLVAPAIKKTLSDLGLDFLDLYLIHWPMAYQEGGDLFPEKDG-KTLYSDADYVDTWKAMEKLVQQGLTKSIGVSNFNSEQLERILAVASIKPVTNQIESHPYLNQKKLIEFCKSKDVTITAYSPL-GSPDRPWAKPDDPQLLDDPKVKEVAERYKKTPAQILIRYQVQRGNITIPKSVTKSRIEENAQIFDFELSEEDIAVIDSFDCNGRVCHLTHVKDHKHYPF 315          
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A0L0BNI7 (Aldo_ket_red domain-containing protein OS=Lucilia cuprina OX=7375 GN=FF38_05882 PE=4 SV=1)

HSP 1 Score: 311.612 bits (797), Expect = 4.454e-101
Identity = 159/317 (50.16%), Postives = 212/317 (66.88%), Query Frame = 1
Query:   73 LNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK--MHKNYPFGED 1014
            +N+ T+ L SGH+MP+ GLGTW S  GEV  AV++A+++GY+ IDCA  Y NE E+GE +E  I+ G VKRE+LFVTSKLWN+FHRP+LV+   E TL+NLKLSY+D++LIH P+ YK G +LFP  +  K    DVD V+TWK ME LV  G V+SIG+SNFN KQ++ +L  + I PA NQ+E + Y   KKL+EFC    + ITAYSPL G+PNRP         +EDPK++ +A+KY  T  QILI Y + RG + IPKSV+  R+  N      +L+ ED   +DS + N R   P L +   H +YPF +D
Sbjct:    2 VNVPTITLSSGHKMPVLGLGTWGSPKGEVAQAVKDAIDIGYRHIDCAHVYQNEHEVGEGIEAKINEGVVKREDLFVTSKLWNTFHRPDLVRGACETTLKNLKLSYIDMYLIHWPMGYKEGDDLFPVDEAGKTAYSDVDYVDTWKEMEKLVQDGLVKSIGISNFNKKQIERVLAVATIPPATNQIECHPYLNQKKLMEFCKSKNIAITAYSPL-GSPNRPWAKAGDPVLMEDPKIVAIAEKYQKTPAQILIRYQLQRGNIVIPKSVTKSRIASNFDVFGFELSAEDINTIDSFDCNGRFV-PILSEAGAHPHYPFHDD 316          
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A226F456 (Aldose reductase OS=Folsomia candida OX=158441 GN=Fcan01_03959 PE=4 SV=1)

HSP 1 Score: 311.227 bits (796), Expect = 7.433e-101
Identity = 154/308 (50.00%), Postives = 209/308 (67.86%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK-PGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            TVKL +G E+P FGLGTW SKPGEV+ AVENA+++GY++IDCA AY NE+E+G+ +   I  G VKRE+LFVT KLWN+FHRP+LV +G+++TL +L L Y+DL+LIH P+ YK  G LFP     K    DVD ++TWK ME  V +G+ ++IG SNFN  QV+ +L    IKPAM QVE + Y    KL+E+C    + +TAYSPL G+P+RP         L DPK+  +A+KY  +  QI++ +   RGL+ IPK+VS  RLEENI   + KLT ED + ++S + N R C+ +  K HK +PF
Sbjct:   29 TVKLNNGAEIPAFGLGTWKSKPGEVRAAVENAIDVGYRMIDCALAYQNENEVGQAIATKIKEGVVKREDLFVTGKLWNTFHRPDLVPIGIKKTLTDLGLDYVDLYLIHWPMGYKEDGELFPKDADGKFMYSDVDYLDTWKEMEAAVRAGQTKAIGFSNFNSDQVERVLQKGTIKPAMLQVECHPYLNQSKLIEWCQGKDIPVTAYSPL-GSPDRPWAKPTDPNLLTDPKLEAIAKKYGKSTAQIILRWNAQRGLIIIPKTVSKARLEENISIFDFKLTHEDMELINSFDCNGRGCHLDWVKDHKYWPF 335          
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: akr1b1.2 (aldose reductase-like [Source:NCBI gene;Acc:103035339])

HSP 1 Score: 263.462 bits (672), Expect = 6.827e-86
Identity = 140/310 (45.16%), Postives = 207/310 (66.77%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            +VKL +G +MPI GLGTW S PG+V  AV+ A++ GY+ ID A+ Y NE E+GE ++  I  G VKREELF+ SKLW +FH+   VK   ++TL +L+L YLDL+L+H P+ ++ G  L P  ++     +D + ++TW+ ME LVD+G V+SIG+SNFN +Q++ IL+    + KPA NQ+E + Y   +KLV+FCL  G+ +TAYSPL G+P+RP    +    L+DP +  +AQKYN T  Q+LI + I R ++ IPKS++  R++EN +  + KLTDE+ + +   N N R+C  +    HK+YPF
Sbjct:    4 SVKLSTGADMPILGLGTWKSAPGKVTEAVKAAISAGYRHIDGAFVYQNEKEVGEGIQAMIKEGAVKREELFIVSKLWCTFHKKSAVKGACQKTLSDLQLDYLDLYLVHWPMGFQAGTELLPLDNEGLTINDDTNFLDTWEGMEELVDAGLVKSIGISNFNREQIEAILNKPGLKYKPANNQIECHPYLTQEKLVDFCLSKGISVTAYSPL-GSPDRPWAKPEDPSLLDDPNIKAIAQKYNKTTAQVLIRFHIERNIIVIPKSITPSRIQENFQVFDFKLTDEEMKTILGFNKNFRVCPMQWSVKHKDYPF 312          
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: ENSAMXT00000039994.1 (aldose reductase-like [Source:NCBI gene;Acc:103040561])

HSP 1 Score: 258.07 bits (658), Expect = 8.191e-84
Identity = 130/313 (41.53%), Postives = 197/313 (62.94%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            ++ L +G  MP+ GLGTW S PG+V+ AV+ A+  GY+ ID A+ Y NE E+G  +   I+   VKRE+LF+ SKLW +FH   LV+   E+TL +L L YLDL+L+H P+ ++PG NLFP   + +   +  + ++TW+ ME LVD+G V++IG+SNFN  Q++ IL+    + KPA+NQVE + Y    +L+ +C   G+ +TAYSPL G+P+RP         L+DP +  +A K+  +  Q+LI + I R +V IPKS +A R++EN +  + KL+ ++ Q + S N N R C  E    HK+YP   +
Sbjct:    4 SITLNTGARMPLVGLGTWKSTPGQVEEAVKAAIMAGYRHIDGAYVYENEKEVGAAVHAMINQKVVKREDLFIVSKLWCTFHERHLVRGACEKTLSDLNLPYLDLYLVHLPVGFQPGDNLFPFDTEGQAIPDKSNFLDTWEEMEKLVDAGLVKAIGISNFNHFQIEAILNKPGLKYKPAINQVECHPYLTQVRLINYCHSKGIAVTAYSPL-GSPDRPWAKPGDPSLLDDPNIKAIADKHKKSPAQVLIRFHIERNVVVIPKSANAKRIKENFQVFDFKLSPQEMQTILSFNRNWRTCPFEWATKHKDYPLNAE 315          
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: ENSAMXT00000046832.1 (aldose reductase-like [Source:NCBI gene;Acc:103040561])

HSP 1 Score: 256.144 bits (653), Expect = 4.732e-83
Identity = 135/312 (43.27%), Postives = 198/312 (63.46%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFP-DADKFKDEIED-VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            ++ L +G  MP  GLGTW S PG+V+ AV+ A+  GY+ ID A+AY NE E+G  +   I+   VKRE+LF+ SKLW++FH   LV+   E TL +L L Y+DL+L+H P+ +KPG +L P DAD   + I D  + ++TW+ ME LVD+G V++IG+SNFN  Q++ +L+    + KP  NQ+E + Y    KL++FC   G+ ITAYSPL G+P+RP         L+DPK+  +A K+  T  Q+LI + I R +  IPKSV+  R++ENI+  + KL+ E+   + S N N R+ + E    HK+YP 
Sbjct:    4 SIPLNNGARMPTVGLGTWKSTPGQVEEAVKAAILAGYRHIDGAYAYRNEKEVGAAVHAMINQKVVKREDLFIVSKLWSTFHERHLVRGACETTLSDLNLPYIDLYLMHCPMGFKPGEDLLPFDAD--GECIPDNSNFLDTWEEMEKLVDAGLVKAIGISNFNRAQIEALLNKPGLKYKPVTNQIECHPYLTQVKLIDFCHSKGITITAYSPL-GSPDRPWAKPGDPSLLDDPKIKAIADKHKKTTAQVLIRFHIERNVAVIPKSVNPARIKENIQVFDFKLSPEEMSTIMSFNRNWRIAHFEWATKHKDYPL 312          
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: ENSAMXT00000052600.1 (aldose reductase-like [Source:NCBI gene;Acc:103040561])

HSP 1 Score: 247.284 bits (630), Expect = 8.976e-80
Identity = 131/302 (43.38%), Postives = 193/302 (63.91%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFP-DADKFKDEIED-VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPE 975
            ++ L +G  MP  GLGTW S PG+V+ AV+ A+  GY+ ID A+AY NE E+G  +   I+   VKRE+LF+ SKLW++FH   LV+   E TL +L L Y+DL+L+H P+ +KPG +L P DAD   + I D  + ++TW+ ME LVD+G V++IG+SNFN  Q++ +L+    + KP  NQ+E + Y    KL++FC   G+ ITAYSPL G+P+RP         L+DPK+  +A K+  T  Q+LI + I R +  IPKSV+  R++ENI+  + KL+ E+   + S N N R+ + E
Sbjct:    4 SIPLNNGARMPTVGLGTWKSTPGQVEEAVKAAILAGYRHIDGAYAYRNEKEVGAAVHAMINQKVVKREDLFIVSKLWSTFHERHLVRGACETTLSDLNLPYIDLYLMHCPMGFKPGEDLLPFDAD--GECIPDNSNFLDTWEEMEKLVDAGLVKAIGISNFNRAQIEALLNKPGLKYKPVTNQIECHPYLTQVKLIDFCHSKGITITAYSPL-GSPDRPWAKPGDPSLLDDPKIKAIADKHKKTTAQVLIRFHIERNVAVIPKSVNPARIKENIQVFDFKLSPEEMSTIMSFNRNWRIAHFE 302          
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: ENSAMXT00000036555.1 (aldose reductase-like [Source:NCBI gene;Acc:103035023])

HSP 1 Score: 247.669 bits (631), Expect = 1.014e-79
Identity = 126/310 (40.65%), Postives = 193/310 (62.26%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            T+ L +G +MPI GLGTW S PG+V+ AV+ A+  GY+ ID A  Y NE E+G  +   I  G VKRE+LF+ +KLW + H+  LV+   E+ L++L L Y+DL+L+H P+ + P N +FP   + +   +D + ++TW+ ME LVD G V++IG+SNFN  Q++ IL+   +  KP  NQ+E + Y    KL+++C   G+ +TAYSPL G+P+RP         LEDPK+  +A KYN +  Q+LI + + R +  IPKS +  R++EN++  + KL +E+   + S N N R+   E    HK++P 
Sbjct:    5 TITLSTGAQMPIIGLGTWKSIPGQVEEAVKTAILAGYRHIDGAVVYENEKEVGTAIRAMIDQGVVKREDLFIVTKLWCTCHQRHLVREACEKALKDLMLDYVDLYLMHMPMGFTPSNEIFPLDAEGQCISDDSNFLDTWEEMEKLVDDGLVKAIGISNFNHFQIEAILNKPGLKHKPVNNQIECHPYLTQVKLIDYCQSKGIAVTAYSPL-GSPDRPWAKPGDPSLLEDPKIKAIAAKYNKSPAQVLIRFHVDRNVAAIPKSANPGRIKENLQVFDFKLNNEEMNTILSFNRNWRILPMEWATKHKDFPL 313          
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: akr1a1b (aldo-keto reductase family 1, member A1b (aldehyde reductase) [Source:NCBI gene;Acc:799805])

HSP 1 Score: 209.92 bits (533), Expect = 7.780e-66
Identity = 112/250 (44.80%), Postives = 160/250 (64.00%), Query Frame = 1
Query:  154 EVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNL-FPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILIT-YTIHRGLVTIPKSVSALRLEENIK 894
            +VK AV +ALN GY+ IDCA  Y NE+E+GE L      GK + RE++FVTSKLWN+ H PE V+    ++L++LKL +LDL+LIH P  ++ G++ FP  +      +  D  ETW+AME LV+ G VR+IG+SNFN +QV  I+  + +KPA+ QVE + Y   K L+  C   GV +TAYSPL G+P+R          LE+P +  LA KY  +  Q++I  + + RG++ IPKSV+  R+ ENI+
Sbjct:    1 QVKAAVVSALNSGYRHIDCAAVYGNEAEVGEALTECFGAGKPIAREDVFVTSKLWNTKHHPEDVEPSCRKSLQDLKLDFLDLYLIHWPHGFERGDIPFPKNEDGTVRYDYTDYRETWRAMERLVEGGLVRAIGLSNFNSRQVDEIIAIATVKPAILQVESHPYLSQKALLTHCTARGVALTAYSPL-GSPDRAWRQSHEPVVLEEPAIRSLADKYGKSPAQVIIRWWQVQRGVLVIPKSVTPSRIVENIQ 249          
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005212.1 (pep scaffold:Pmarinus_7.0:GL480334:1640:10257:1 gene:ENSPMAG00000004669.1 transcript:ENSPMAT00000005212.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 209.149 bits (531), Expect = 1.252e-65
Identity = 127/298 (42.62%), Postives = 186/298 (62.42%), Query Frame = 1
Query:  142 SKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK--PGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRP---LEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM--HKNYPFGED 1014
            SKP +V  AVE A+  GY+ +D A+ Y NE E+G  +   I+ G V R++LF+ SKLW  FH P  VK    +TL +L L YLDL+L+H+P+ Y+     L+P  D  +    DVD ++TWKAME+LV  G V+S+GVSNFNI Q+  +L  + IKP +NQVE++ Y    KLV+FC   G+ +TAYSP  G+P+RP + +K   P   L+DP V ++A+K++ ++GQIL+ Y I   +V IPKSV+   + +N K  +  L +ED +KL  L+    + N    K+  HK +P  +D
Sbjct:    2 SKPQQVCKAVEAAIEAGYRHVDGAYVYQNEDEVGAGVRACIAKGIVSRDQLFIVSKLWGKFHAPADVKQCFMKTLTDLGLDYLDLYLMHSPMGYQNVGEELYPTMDG-RLLCSDVDYLDTWKAMEDLVKEGLVKSLGVSNFNIPQLNRLLSSASIKPVVNQVELHPYNAQPKLVQFCKSQGIVLTAYSPF-GSPDRPRKLDK--DPGNLLQDPVVADIAKKHSKSSGQILLRYHIENNIVVIPKSVTPANIIQNSKVFDFSLDEEDLKKLAQLDRGWSLANSLFTKLKDHKYFPVNDD 295          
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009052.1 (pep scaffold:Pmarinus_7.0:GL484886:6662:24104:-1 gene:ENSPMAG00000008170.1 transcript:ENSPMAT00000009052.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 191.43 bits (485), Expect = 1.474e-59
Identity = 103/226 (45.58%), Postives = 145/226 (64.16%), Query Frame = 1
Query:  307 KLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK--PGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRP---LEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCN 969
            +LW  +H P  VK+G  +TL +LKL YLDLFL+H+P+++K    +L+P  D  K    DVD V+TWKAME LV  G V+SIGVSNFNI Q+Q +L  + IKPA+NQVE++ Y P  +L+EFC  N V +TAYSP  G+P+R  + EK   P   L+DP V  +  K+  T+ Q+L+ Y   R +V IPKS++  R+ +N ++    L  ED +KL  L  + R C+
Sbjct:    2 QLWGKYHAPADVKIGFMKTLTDLKLDYLDLFLMHSPMAFKNEGDDLWPIKDG-KILAADVDYVDTWKAMEVLVKEGLVKSIGVSNFNIAQLQRLLSVATIKPAVNQVELHPYLPQPELIEFCQSNNVVLTAYSPF-GSPDREFKNEK-NDPCNLLQDPVVEAIGSKHGKTSAQVLLRYHTQRNIVVIPKSITPSRIVQNAQSFGFTLDGEDTKKLQGLRRDWRACD 224          
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: zgc:110782 (zgc:110782 [Source:ZFIN;Acc:ZDB-GENE-050320-51])

HSP 1 Score: 162.155 bits (409), Expect = 1.357e-47
Identity = 98/299 (32.78%), Postives = 155/299 (51.84%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKL-AVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLK-LSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMC-NP 972
            +VKL SG  MP+ GLGT+     EV   A+  AL  GY+ +D A  Y NE+++   L   +    + R ++F+TSKL      P      L+ +L NL    YLDL+L+H P +       P  D    E+      E+W+ +E L   GK+R+IGVSN+ ++ ++ +L    IKP++ QVE + +   K+L+E+C  +G+ + AYS LG           +   L +  V E+A ++  T  Q+L+ + + RG+  IPKS    R+  N    + KL  ED + LD ++  +  C NP
Sbjct:   10 SVKLNSGTAMPLLGLGTFKMHGYEVVYGALAAALEHGYRAVDTAAVYSNEADVARALRELLPRHGLTRADVFITSKLAPRDQGPGAAAAALK-SLENLDPGGYLDLYLVHWPGTQG----LPGEDPRNQELRQ----ESWRLLEKLHGEGKLRAIGVSNYTVRHLEELLATCSIKPSVLQVEYHPHLVQKELLEYCQAHGIHMQAYSSLG-----------MGHLLGEVTVQEVASRHGRTPAQVLLRWALERGVGVIPKSTGVERVASNAAVFDFKLAQEDIETLDGMDKQLHYCWNP 288          
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: akr1b1.1 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-040625-7])

HSP 1 Score: 112.464 bits (280), Expect = 9.676e-30
Identity = 69/210 (32.86%), Postives = 112/210 (53.33%), Query Frame = 1
Query:  424 KPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIK--PAMNQ--------VEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKL--RRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            +PG +LFP  +  K   +  D ++TW+AME LVD+G +R++G+SNFN  Q++ IL+   +K  P +NQ        +  N+Y      +  C K       YS     P   ++   L  +  L+ P V  ++  ++    ++LI + + RG++ IPKSV+  R+ ENI+  + +LT +D + L SLN N R C  +    HK+YPF  D
Sbjct:    2 QPGEDLFPLDENDKVITDGTDFLDTWEAMEALVDAGVIRALGLSNFNRDQIRKILNKPGLKHKPVVNQQYSLHHLHLSANVY------ISKCYKKNHSACLYSKYHTCP---LQWNALGNKSFLKFPSVKSISNSHSLIGSEVLIRFHVQRGVMVIPKSVTKARIHENIQVFDFELTADDMKSLTSLNKNWRACPMQWAVDHKDYPFNTD 202          
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: GRE3 (Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000001146])

HSP 1 Score: 196.052 bits (497), Expect = 1.814e-60
Identity = 117/314 (37.26%), Postives = 178/314 (56.69%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK---------PGNLFPDADKFKDEIED--VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLE------LAQKY-NATAGQILITYTIHRGLVTIPKSVSALRLEENIK-ALNIKLTDEDFQKLDSLNVNIRMCNP 972
            V L +G +MP+ GLG W          +  A+ LGY+L D A  Y NE E+GE + + IS G V R+++FV SKLWN+FH P+ VK+ L++TL ++ L YLDL+ IH PI++K         PG      D+ K  I +  V +++T++A+E  VD G ++SIGVSNF    +Q++L   RIKP   Q+E + Y   + LVEFC  + +Q+ AYS  G  P   IE + L+     P + E      ++Q +  +T  Q+L+ +   RG+  IPKS    RL  N++      LT+++ + + +LN NIR  +P
Sbjct:    5 VTLNNGLKMPLVGLGCWKIDKKVCANQIYEAIKLGYRLFDGACDYGNEKEVGEGIRKAISEGLVSRKDIFVVSKLWNNFHHPDHVKLALKKTLSDMGLDYLDLYYIHFPIAFKYVPFEEKYPPGFYTGADDEKKGHITEAHVPIIDTYRALEECVDEGLIKSIGVSNFQGSLIQDLLRGCRIKPVALQIEHHPYLTQEHLVEFCKLHDIQVVAYSSFG--PQSFIEMD-LQLAKTTPTLFENDVIKKVSQNHPGSTTSQVLLRWATQRGIAVIPKSSKKERLLGNLEIEKKFTLTEQELKDISALNANIRFNDP 315          
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: GCY1 (Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication [Source:SGD;Acc:S000005646])

HSP 1 Score: 184.111 bits (466), Expect = 6.689e-56
Identity = 115/327 (35.17%), Postives = 182/327 (55.66%), Query Frame = 1
Query:   67 FHLNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLW-NSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNL-------FP---DADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNIL--DHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNY-PF 1005
             H +   + L +G ++P  GLGTW SK  +   AV  AL  GY+ ID A  Y NE ++G+     I    V REE+FVT+KLW    H PE   V L+++L+ L L Y+DL+L+H P    P  +        P   D  +  D I + + ++TW+ M+ L  +GK +++GVSNF+I  ++++L    +++ PA NQVE++   P  +L+ FC   G+ + AYSPLG   + P+        L++P +LE+A+K N   G ++I++ + RG V +PKSV+  R++ N K     L+ EDF+ ++    NI     E   +H N+ PF
Sbjct:    5 LHDSTKILSLNTGAQIPQIGLGTWQSKENDAYKAVLTALKDGYRHIDTAAIYRNEDQVGQA----IKDSGVPREEIFVTTKLWCTQHHEPE---VALDQSLKRLGLDYVDLYLMHWPARLDPAYIKNEDILSVPTKKDGSRAVD-ITNWNFIKTWELMQELPKTGKTKAVGVSNFSINNLKDLLASQGNKLTPAANQVEIHPLLPQDELINFCKSKGIVVEAYSPLGST-DAPL--------LKEPVILEIAKKNNVQPGHVVISWHVQRGYVVLPKSVNPDRIKTNRKIFT--LSTEDFEAIN----NISKEKGEKRVVHPNWSPF 308          
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: YPR1 (NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant [Source:SGD;Acc:S000002776])

HSP 1 Score: 176.022 bits (445), Expect = 8.601e-53
Identity = 103/301 (34.22%), Postives = 172/301 (57.14%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHR-PELVKVGLEETLRNLKLSYLDLFLIHTPISYKP-----GNLFPDADKFKDEIEDVD-----LVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILD--HSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLN 948
            T+KL +G  +P+ G GTW S       +V  AL  GY+ ID A  Y NE E+G    R I    V REE+F+T+KLW +  R PE     L ++L+ L L Y+DL+L+H P+  K      GN+       +D   D+D      ++TW+ M+ L  +GK +++GVSNF+I  ++ +L+  ++++ PA NQ+E++   P  +L+ FC + G+ + AYSP G A N P+        L++  ++++A+K+     Q++I+++I RG V + KSV+  R+  N K     L ++DF+ + +L+
Sbjct:   11 TLKLNTGASIPVLGFGTWRSVDNNGYHSVIAALKAGYRHIDAAAIYLNEEEVG----RAIKDSGVPREEIFITTKLWGTEQRDPE---AALNKSLKRLGLDYVDLYLMHWPVPLKTDRVTDGNVLC-IPTLEDGTVDIDTKEWNFIKTWELMQELPKTGKTKAVGVSNFSINNIKELLESPNNKVVPATNQIEIHPLLPQDELIAFCKEKGIVVEAYSPFGSA-NAPL--------LKEQAIIDMAKKHGVEPAQLIISWSIQRGYVVLAKSVNPERIVSNFKIFT--LPEDDFKTISNLS 292          
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: ARA1 (NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product [Source:SGD;Acc:S000000353])

HSP 1 Score: 174.481 bits (441), Expect = 7.209e-52
Identity = 109/301 (36.21%), Postives = 172/301 (57.14%), Query Frame = 1
Query:   94 LKSGHEMPIFGLGTW--LSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK----PGNL-----FPDADKFKD-EIEDVDLVETWKAMENLV---DSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLG--GAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSL 945
            L +G  +P  GLGT     K  E K AV+ A+  GY+ ID AWAY  E  +GE ++  +  G +KRE+LF+T+K+W      + V   L E+L+ L L Y+DL L H P+ ++    P  +      P  D  K     D D +ET+K +E +    +  +VR+IGVSNF+I+ ++ ++   R+KP +NQVE + + P  +L +FC  + + +TAYSPLG  GAPN           L+ P V +LA+KYN T   +LI+Y I +G + IP+S++ +R+  +I+  +  LT ++ Q+L+  
Sbjct:   27 LNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPVLW--DEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKGISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN-----------LKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFAS--LTKDELQELNDF 312          
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: YJR096W_mRNA (Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003857])

HSP 1 Score: 151.369 bits (381), Expect = 9.288e-44
Identity = 90/288 (31.25%), Postives = 158/288 (54.86%), Query Frame = 1
Query:   91 KLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYIS--GGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLK-LSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIK--PAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLD 939
            KL +G ++P   LGT+     +    V   +  GY+  D A  Y NE E+G+ + ++++   G  KREE+F T+KLWNS +  +  K  + + L  +  L Y+DL LIH+P+         +  K +        +ETW+AM+  VD G V+SIGVSN+  K +  +L+   +K  P +NQ+E++ +   ++L ++C   G+ + A++PL         G K+     +P +L++ ++ +   GQ+LI +++  G + +PK+ +  RLE N+ A N +L+DE  + LD
Sbjct:    7 KLSNGFKIPSIALGTYDIPRSQTAEIVYEGVKCGYRHFDTAVLYGNEKEVGDGIIKWLNEDPGNHKREEIFYTTKLWNSQNGYKRAKAAIRQCLNEVSGLQYIDLLLIHSPL---------EGSKLR--------LETWRAMQEAVDEGLVKSIGVSNYGKKHIDELLNWPELKHKPVVNQIEISPWIMRQELADYCKSKGLVVEAFAPL-------CHGYKMT----NPDLLKVCKEVDRNPGQVLIRWSLQHGYLPLPKTKTVKRLEGNLAAYNFELSDEQMKFLD 266          
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO45157 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTW5])

HSP 1 Score: 236.113 bits (601), Expect = 1.532e-75
Identity = 143/326 (43.87%), Postives = 204/326 (62.58%), Query Frame = 1
Query:   79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDV-----DLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-----------HKNYPF 1005
            M TVKL +G EMP+ GLGTW SKPG+V+ AV+ A+  GY+ IDCA+AY NE E+G+ L R + G  V+R++LF+TSKLWN+ H P+ V+    ++L++L L YLDL+LIH P+S++ G+  FP     KDE  +V     D  +TWKAME LVD G V++IG+SNFN KQV +I   +RIKP  NQVE +      KL++   K+ +Q  AYSPLG   +RP         + DP ++ LA +Y+ T  QI I + I RG++ IPKSV+  R++ N +  + +L+ ED   ++ LN + R C P + K+           H +YPF
Sbjct:    1 MATVKLNNGLEMPVLGLGTWKSKPGQVENAVKFAIKEGYRHIDCAYAYRNEKEVGDAL-RELLGSVVERKDLFITSKLWNTKHNPKDVRSNCVDSLKDLGLDYLDLYLIHWPLSFRDGDEFFP-----KDEQGNVLYAYHDPCDTWKAMEKLVDEGLVKAIGLSNFNSKQVDDICAIARIKPVANQVECHPLLNQAKLIDHHKKHNIQTIAYSPLGSL-DRPWAKPDDPHVMRDPTMVALADRYSRTVAQICIRFQIQRGVLVIPKSVTPERIKSNFQVFDFELSAEDMATIEGLNRDWRACLP-MKKLADGTMVPRDGEHPHYPF 318          
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO26953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TAL8])

HSP 1 Score: 235.343 bits (599), Expect = 3.057e-75
Identity = 142/326 (43.56%), Postives = 204/326 (62.58%), Query Frame = 1
Query:   79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDV-----DLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-----------HKNYPF 1005
            M TVKL +G EMP+ GLGTW SKPG+V+ AV+ A+  GY+ IDCA+AY NE E+G+ L R + G  V+R++LF+TSKLWN+ H P+ V+    ++L++L L YLDL+LIH P+S++ G+  FP     KDE  +V     D  +TWKAME LVD G V++IG+SNFN KQV +I   +RIKP  NQVE +      KL++   K+ +Q  AYSPLG   +RP         + DP ++ +A +Y+ T  QI I + I RG++ IPKSV+  R++ N +  + +L+ ED   ++ LN + R C P + K+           H +YPF
Sbjct:    1 MATVKLNNGLEMPVLGLGTWKSKPGQVENAVKFAIKEGYRHIDCAYAYRNEKEVGDAL-RELLGSVVERKDLFITSKLWNTKHNPKDVRSNCVDSLKDLGLDYLDLYLIHWPLSFRDGDEFFP-----KDEQGNVLYAYHDPCDTWKAMEKLVDEGLVKAIGLSNFNSKQVDDICAIARIKPVANQVECHPLLNQAKLIDHHKKHNIQTIAYSPLGSL-DRPWAKPDDPHVMRDPTMVAMADRYSRTVAQICIRFQIQRGVLVIPKSVTPERIKSNFQVFDFELSAEDMATIEGLNRDWRACLP-MKKLADGTMVPRDGEHPHYPF 318          
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO36411 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIT3])

HSP 1 Score: 224.172 bits (570), Expect = 6.597e-71
Identity = 130/301 (43.19%), Postives = 183/301 (60.80%), Query Frame = 1
Query:   73 LNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPD--ADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRP---LEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIR 960
            +  +  KL +G  +P   LGTW S   EV  AV  A+ LGY+ IDCA  Y NE EIGE L   ++ GKVKREELFVTSKLW   H P+ V    + TL+NL+L YLDL+LIH P+++K G   P   A+       +  +  TW+AME LV  G  ++IGVSNF++K++  +L+ + I PA NQVE++ Y P +KL EFC   G+ +TAYSPLG  P R +  E+L R    +E+P + E+A K+N +  ++L+ + I RG   +PKS S   L +N  AL + LTD++   + S+    R
Sbjct:    3 MKQIFCKLNTGASIPAMALGTWQSSKEEVGNAVRLAIELGYRHIDCAEIYGNEGEIGEALSEVLTEGKVKREELFVTSKLWCDSHHPDDVLPACQATLKNLQLDYLDLYLIHIPVAFKKGVRLPHSIAEGIIGYTPE-GVQNTWQAMEGLVAKGLCKAIGVSNFSVKRLNKLLETASIVPACNQVELHPYLPQEKLKEFCDSKGILLTAYSPLGN-PGRLVPKERLEREPKVMEEPVIKEIAAKHNCSVARVLLRWGIQRGYPVLPKSTSRDHLHDNFSALGLVLTDDEMAAIKSITTRQR 301          
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO45940 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRF6])

HSP 1 Score: 171.014 bits (432), Expect = 6.045e-51
Identity = 102/292 (34.93%), Postives = 152/292 (52.05%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIR 960
            T  L  G+++P FGLG +       K AV  AL  GY++ID A +Y NE  +GE L        V R E+++ +K++++ H  E      + +L  L + Y+DL+LIH P+                      +V +W+AM  L   G  RSIGVSNFNI  ++ +  HS I P +NQ+EV+ Y   ++LV+FC K+ + I AYSPL         GEK    L DP +  L  KY  T  Q+L+ +++ +G + I KSV   R+ EN+   N  ++  D + LD L  N+R
Sbjct:    6 TRTLSDGYKIPRFGLGLYDLDEKHTKQAVLWALENGYRMIDTAASYNNEKRVGEALRE----SAVPRSEVYLVTKVYHTDHGYEKTMKAYDRSLSALGVDYVDLYLIHFPVP-------------------AGVVGSWEAMAELQGKGLTRSIGVSNFNIHHLEALQKHSVIPPVVNQIEVHPYLQMEELVDFCRKHSIAIQAYSPL-------TRGEK----LHDPLLRSLGDKYGKTPAQVLLRWSLQKGYICISKSVQLSRIIENVDVFNFTISMADMEILDGLEENLR 263          
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO39694 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9F3])

HSP 1 Score: 154.836 bits (390), Expect = 8.520e-45
Identity = 95/289 (32.87%), Postives = 153/289 (52.94%), Query Frame = 1
Query:   94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIR 960
            +  G ++P+ GLG   +     K AV  AL  GY+LID A  Y NE  +GE     +    + R E++V +K++ + H  +       ++L  L L Y+DL+LIH P+        P             +V +W+AM +L   G +RSIGVSNFNI+ ++ +   + + PA+NQ+EV+ +   K+L ++C ++ + I A+SPL        +GEKL     DP +  +A+KYN T  QIL+ +++ +G   IPKS    R++EN K  +  +   D + +D L  N R
Sbjct:    1 MNDGRKIPLLGLG---AHDIHSKQAVLWALESGYRLIDTASRYHNEQSVGEA----VRCSNIPRCEIYVVTKVYFTEHGYKETMDAFYKSLTRLGLGYVDLYLIHFPV--------PSG-----------VVGSWQAMIDLRSRGLIRSIGVSNFNIQHLEALRQQTGVVPAVNQIEVHPFLQMKELTQYCKRHNITIQAFSPL-------TKGEKLC----DPILSYVAKKYNKTTAQILVRWSLQKGYACIPKSAQLERIKENAKVFDFSIDMADMELIDGLEENYR 252          
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: akr1b1.1 (aldose reductase [Source:NCBI gene;Acc:101157264])

HSP 1 Score: 251.521 bits (641), Expect = 3.685e-81
Identity = 137/312 (43.91%), Postives = 204/312 (65.38%), Query Frame = 1
Query:   79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            M TV L +G +MP+ GLGTW    G+V  AV+ A++ GY+ IDCA+ Y NE EIG  ++  I  G VKREELF+ SKLW++FH P LVK   E+TL +LKL YLDL+L+H P + +PG  LFP  ++ +  ++D + ++TW+AME LVD G V++IGVSNFN +Q++ IL+   +  KP  NQ+E + Y   +K++ +C   G+ +TA++PL G+P RP    +    LE+P + E+A KY  ++ QIL+ +   R +V + KSV+  R++ENI+  + +L++ED  KL S+N N R         HK+YPF
Sbjct:    2 MTTVTLSTGAKMPVVGLGTWRGGQGKVGEAVKLAISNGYRHIDCAYVYENEEEIGAAIQAMIDQGVVKREELFIVSKLWSTFHVPSLVKSACEKTLSDLKLDYLDLYLMHFPTAMRPGKELFPKDEENQTILDDTNFLDTWEAMEKLVDDGAVKAIGVSNFNKEQIEAILNKPGLKHKPVTNQIECHPYLNQEKMINYCKSKGIFVTAFAPL-GSPERPWASPEDPTLLEEPIIKEIAAKYKKSSAQILMKFHTQRSVVVLAKSVTPSRIKENIQLFDFELSEEDMAKLRSMNKNWRGFPAAWVAKHKHYPF 312          
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: akr1a1a (alcohol dehydrogenase [NADP(+)] A-like [Source:NCBI gene;Acc:101175168])

HSP 1 Score: 247.669 bits (631), Expect = 1.305e-79
Identity = 132/317 (41.64%), Postives = 188/317 (59.31%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---------MHKNYPF 1005
            V L SG  MP+ GLGTW S  G+VK AV  AL  GY+ IDCA  Y NE EIGE L   +  GK ++REELFVTSKLWN+ H PE V+     +L +L LSYLDL+L+H P++++ G  L P  +       +    +TWKAMENLVD G V++IG+SNFN +Q++ I+  ++ KP +NQVE + Y     L+  C    + +TAYSPLG   +RP         LEDPK+  +AQ+Y  +  Q+++ + I RG+  IPKSV+  R+++N+   +  L+ ED + ++S +   R   P   K          H ++PF
Sbjct:    5 VTLSSGQRMPMIGLGTWKSSAGQVKQAVVAALECGYRHIDCAAVYGNEQEIGEALALCVGPGKTLRREELFVTSKLWNTKHDPEDVEDACRTSLAHLGLSYLDLYLMHWPMAFQKGKELMPRRNDGTICYSNTHYRDTWKAMENLVDKGLVKAIGLSNFNARQMEEIIRVAKHKPVVNQVECHPYLSQADLLSHCQSLAICVTAYSPLGSG-DRPWASPDEPSLLEDPKLGVIAQRYQKSPAQVILRWHIQRGVACIPKSVTLSRIQQNLNVFDFNLSQEDMKLINSFSCKRRFIVPTAVKDGKTVWRDAEHPHFPF 320          
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: akr1a1b (aldo-keto reductase family 1 member A1 [Source:NCBI gene;Acc:101172969])

HSP 1 Score: 243.817 bits (621), Expect = 5.087e-78
Identity = 130/295 (44.07%), Postives = 191/295 (64.75%), Query Frame = 1
Query:   94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNL-FPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNP 972
            L +G +MP+ GLGTW S+PG+VK AV  AL  GY+ IDCA  Y NE+EIGE L+  +   K ++RE++F+TSKLWN+ H PE V+  L +TL++L+L YLDL+LIH P  ++ G++ FP  +      + +D   TW AME LV+ G VRSIG+SNFN +QV +IL  + IKP + QVE + Y    +L+  C   G+ +TAYSPL G+P+R  +  +    L++P V+ LA+KY  +  QIL+ +   RG+V IPKSV+  R++ENI+  +  L  E+ + + +L+   R   P
Sbjct:    7 LNTGRKMPLVGLGTWKSEPGKVKQAVLWALEAGYRHIDCAAIYGNEAEIGEALKEMLGPSKPLRREDIFITSKLWNTRHHPEDVEPALLKTLKDLQLEYLDLYLIHWPHGFQRGDVPFPKKEDGSLIYDHIDYKLTWAAMEKLVEKGLVRSIGLSNFNSRQVDDILSVASIKPTVLQVESHPYLAQVELLAHCRNRGLVMTAYSPL-GSPDRAWKRPEEPVLLQEPVVISLAEKYQKSPAQILLRWQTQRGVVVIPKSVTESRIKENIQVFDFSLEAEEVKSITALDRGCRYIVP 300          
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: AKR1D1 (3-oxo-5-beta-steroid 4-dehydrogenase [Source:NCBI gene;Acc:101170970])

HSP 1 Score: 241.891 bits (616), Expect = 2.884e-77
Identity = 125/317 (39.43%), Postives = 194/317 (61.20%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTW---LSKP-GEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLF-PDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIK--PAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            ++ L  G+ +P+ GLGT+   ++ P G    AV+ A+ +GY+  D A  Y NE E+G+ +   I+ G VKRE++F   KLWN+FH PELV+  LE+TL+ L+L Y+DL+++  P ++KPG+ F P  +  K      DL  TW+A+E   D+G V+S+GVSNFN +Q++ IL+   +K  P  NQVE + YF   KL+EFC +N + I  YSPLG + +      K    LED  +  +A+KY+ T  Q+ + + + RG+V IPKS ++ R++EN    +  L+DE+ + ++ LN NIR     ++  H  YPF E+
Sbjct:    9 SIPLSDGNRIPLIGLGTYGDPITTPKGATSEAVKLAIEVGYRHFDGALVYFNEHEVGQAIREKIADGTVKREDIFYCGKLWNTFHPPELVRTALEKTLKTLQLDYVDLYIVELPTAFKPGDSFYPRDENGKYLYHTTDLCATWEALEACKDAGLVKSLGVSNFNKRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLEFCRQNNIVIVGYSPLGTSRDASWVNLKCPPLLEDEVLKSVAKKYSKTTAQVCLRFNVQRGVVVIPKSFTSARIKENFDIFDFCLSDEEMKAIEGLNKNIRFVELLMWADHPEYPFHEE 325          
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: zgc:56622 (aldose reductase-related protein 2 [Source:NCBI gene;Acc:101171575])

HSP 1 Score: 241.121 bits (614), Expect = 6.050e-77
Identity = 127/315 (40.32%), Postives = 190/315 (60.32%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWLSK---PGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKP--GNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIE----GEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
            ++L  G  MPI GLGTW S    P  V+ AVE A+  GY+ ID A++Y NE ++G  L   +  G ++RE++F+ SKL  + H PE + + L ++L++L+L +LDL+L+H P+  K     LFP  D  K    D+D V+ W+ ME L  SGKVRSIGVSNF+I Q++ +L   R+ PA+NQVE++ Y     ++EFC    + +TA+SP  G+P RP +    G    + LEDP + ++A+++  +A Q+L+ Y I +G+  IPKS     + +N K  + +L++ED   L SLN   R C  E  K H  YPF
Sbjct:   20 IELNDGSRMPILGLGTWKSSHLPPNSVQGAVEAAIAAGYRHIDTAYSYGNEVDVGRALRSKMRQGIIRREDMFIVSKLCETHHAPEDIPLCLNKSLKDLQLDFLDLYLVHFPVGLKKVGDELFPMKDG-KVLTSDIDYVDVWRGMEALQASGKVRSIGVSNFSILQLERLLALCRVPPAVNQVELHPYLVQADMIEFCKLKNIALTAFSPF-GSPARPPDEFKCGTDPHKLLEDPVIAQIAERHRRSAAQVLLRYHIQQGVSVIPKSDKPHHIIQNTKIFDFQLSEEDMTTLKSLNRGWRGCRIEELKSHPYYPF 332          
BLAST of Aldo-keto reductase vs. Planmine SMEST
Match: SMESG000062723.1 (SMESG000062723.1)

HSP 1 Score: 639.417 bits (1648), Expect = 0.000e+0
Identity = 312/312 (100.00%), Postives = 312/312 (100.00%), Query Frame = 1
Query:   79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED
Sbjct:    1 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 312          
BLAST of Aldo-keto reductase vs. Planmine SMEST
Match: SMESG000081151.1 (SMESG000081151.1)

HSP 1 Score: 479.174 bits (1232), Expect = 6.730e-171
Identity = 234/310 (75.48%), Postives = 270/310 (87.10%), Query Frame = 1
Query:   85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
            ++KL SG+++P FGLGTWLSKPGE+K ++E+ALNLGY  IDCAW YCNE EIG VLE YIS GK+KREELFVTSKLWN+FHRPELVKVG EETL NL+L YLDL+LIH PIS KPGN+ P ADKFKDE++DVDL++TWK ME LVDSGK+RSIG+SNFNI+Q+QNILDH +IKPAM Q+EVNIYFPNKKLVEFCLKN +Q+TAY PLGGAP+RP   E  +RPL DP VLELA+KYNAT G ILI+Y IHRGL+ IPKSVS+ RLEENIKALNIKL+DEDFQ LD+LNVNIR C P +FK+HKNYPF ED
Sbjct:    4 SIKLNSGYDVPNFGLGTWLSKPGEIKASLESALNLGYNHIDCAWVYCNEKEIGGVLEDYISNGKIKREELFVTSKLWNAFHRPELVKVGFEETLSNLRLDYLDLYLIHWPISIKPGNILPSADKFKDELDDVDLIKTWKEMEKLVDSGKIRSIGLSNFNIRQIQNILDHCKIKPAMLQIEVNIYFPNKKLVEFCLKNDIQVTAYCPLGGAPDRPGATEGEKRPLSDPTVLELAKKYNATPGVILISYIIHRGLICIPKSVSSARLEENIKALNIKLSDEDFQLLDNLNVNIRSCCPLMFKLHKNYPFDED 313          
BLAST of Aldo-keto reductase vs. Planmine SMEST
Match: SMESG000015779.1 (SMESG000015779.1)

HSP 1 Score: 147.902 bits (372), Expect = 1.243e-41
Identity = 94/298 (31.54%), Postives = 162/298 (54.36%), Query Frame = 1
Query:   88 VKLKSGHEMPIFGLGTWL-SKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVE----TWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMC 966
            + L    ++P    GT+L ++   ++  ++ AL  GY+ ID A  Y NE+ +G++L+  +    +KRE++F+T+KL  S    E  K  ++ +L  L+L YLDL+LIH P + K             ++  ++ +E    +WKAME     G +RSIGVSN+ IK ++ + +++ I P++NQVE + +    +LV+FC  N +   AYS LG   N         + +E   V +LAQ    +  QIL+ + I++G   +PKS +   +E+NI+  + +LT +  ++L  +N   R C
Sbjct:    2 ITLNDKFKIPSVLFGTYLINEENLLEECLDKALVSGYRGIDTAAVYRNEAFLGKILKSKLLKYNLKREDIFITTKLAPSEQGYEKAKAAIKNSLDKLQLEYLDLYLIHWPGTSKL------------DLTSLEHLENRKGSWKAMEEAKKIGLIRSIGVSNYMIKHLEEMKNYANILPSVNQVECHPFLNQHELVKFCQANNIHFQAYSSLGTTANH-------LKLIEHSTVQKLAQLLQRSPAQILLKWAINQGFSVLPKSTNLEHIEKNIQLFDWQLTVQQMKELFEMNKEERFC 280          
The following BLAST results are available for this feature:
BLAST of Aldo-keto reductase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
AKR1B101.014e-8644.66aldo-keto reductase family 1 member B10 [Source:HG... [more]
AKR1B15.362e-8145.16aldo-keto reductase family 1 member B [Source:HGNC... [more]
AKR1A16.292e-8142.99aldo-keto reductase family 1 member A1 [Source:HGN... [more]
AKR1A16.292e-8142.99aldo-keto reductase family 1 member A1 [Source:HGN... [more]
AKR1A16.292e-8142.99aldo-keto reductase family 1 member A1 [Source:HGN... [more]
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BLAST of Aldo-keto reductase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Y39G8B.17.835e-8042.45pep chromosome:WBcel235:II:13970584:13972970:-1 ge... [more]
Y39G8B.11.821e-7942.45pep chromosome:WBcel235:II:13970789:13972970:-1 ge... [more]
T08H10.12.101e-7941.74pep chromosome:WBcel235:V:4483459:4486543:1 gene:W... [more]
C07D8.61.552e-6135.31pep chromosome:WBcel235:X:7341509:7342780:1 gene:W... [more]
Y39G8B.26.380e-6034.69pep chromosome:WBcel235:II:13973690:13976221:-1 ge... [more]
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BLAST of Aldo-keto reductase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG60831.464e-8240.91gene:FBgn0036183 transcript:FBtr0076137[more]
CG60842.775e-8048.88gene:FBgn0086254 transcript:FBtr0331547[more]
CG60841.248e-7948.87gene:FBgn0086254 transcript:FBtr0076139[more]
CG60845.656e-7748.38gene:FBgn0086254 transcript:FBtr0076138[more]
CG60842.615e-7648.37gene:FBgn0086254 transcript:FBtr0331546[more]
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BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
akr1a1a2.518e-8944.41aldo-keto reductase family 1, member A1a (aldehyde... [more]
akr1a1a3.602e-8944.41aldo-keto reductase family 1, member A1a (aldehyde... [more]
akr1b1.11.313e-8545.05aldo-keto reductase family 1, member B1 (aldose re... [more]
akr1b1.12.091e-8345.97aldo-keto reductase family 1, member B1 (aldose re... [more]
akr1b1.21.267e-7943.87aldo-keto reductase family 1, member B1 (aldose re... [more]
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BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
akr1b13.038e-8244.34aldo-keto reductase family 1, member B1 (aldose re... [more]
akr1c23.812e-7640.32aldo-keto reductase family 1, member C2 [Source:NC... [more]
tm4sf58.473e-7640.38transmembrane 4 L six family member 5 [Source:Xenb... [more]
akr1c8p2.963e-7538.92aldo-keto reductase family 1, member C8, pseudogen... [more]
nudt23.013e-7542.11nudix hydrolase 2 [Source:Xenbase;Acc:XB-GENE-1008... [more]
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BLAST of Aldo-keto reductase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Akr1b31.032e-8345.95aldo-keto reductase family 1, member B3 (aldose re... [more]
Akr1a11.686e-8142.43aldo-keto reductase family 1, member A1 (aldehyde ... [more]
Akr1b89.248e-7944.19aldo-keto reductase family 1, member B8 [Source:MG... [more]
Akr1b105.563e-7844.34aldo-keto reductase family 1, member B10 (aldose r... [more]
Akr1c66.461e-7841.19aldo-keto reductase family 1, member C6 [Source:MG... [more]
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BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6AZW2|A1A1A_DANRE1.901e-8844.41Aldo-keto reductase family 1 member A1-A OS=Danio ... [more]
sp|O60218|AK1BA_HUMAN4.869e-8644.66Aldo-keto reductase family 1 member B10 OS=Homo sa... [more]
sp|P07943|ALDR_RAT6.548e-8346.28Aldo-keto reductase family 1 member B1 OS=Rattus n... [more]
sp|P45376|ALDR_MOUSE7.218e-8345.95Aldo-keto reductase family 1 member B1 OS=Mus musc... [more]
sp|P80276|ALDR_PIG2.886e-8248.24Aldo-keto reductase family 1 member B1 OS=Sus scro... [more]
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BLAST of Aldo-keto reductase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A026WTR51.744e-10348.88Aldo-keto reductase family 1 member B10 OS=Oocerae... [more]
A0A1J1IMG61.596e-10150.00CLUMA_CG013551, isoform A OS=Clunio marinus OX=568... [more]
A0A067QJF42.212e-10150.47Aldo-keto reductase family 1 member B10 OS=Zooterm... [more]
A0A0L0BNI74.454e-10150.16Aldo_ket_red domain-containing protein OS=Lucilia ... [more]
A0A226F4567.433e-10150.00Aldose reductase OS=Folsomia candida OX=158441 GN=... [more]
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BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
akr1b1.26.827e-8645.16aldose reductase-like [Source:NCBI gene;Acc:103035... [more]
ENSAMXT00000039994.18.191e-8441.53aldose reductase-like [Source:NCBI gene;Acc:103040... [more]
ENSAMXT00000046832.14.732e-8343.27aldose reductase-like [Source:NCBI gene;Acc:103040... [more]
ENSAMXT00000052600.18.976e-8043.38aldose reductase-like [Source:NCBI gene;Acc:103040... [more]
ENSAMXT00000036555.11.014e-7940.65aldose reductase-like [Source:NCBI gene;Acc:103035... [more]
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BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
akr1a1b7.780e-6644.80aldo-keto reductase family 1, member A1b (aldehyde... [more]
ENSPMAT00000005212.11.252e-6542.62pep scaffold:Pmarinus_7.0:GL480334:1640:10257:1 ge... [more]
ENSPMAT00000009052.11.474e-5945.58pep scaffold:Pmarinus_7.0:GL484886:6662:24104:-1 g... [more]
zgc:1107821.357e-4732.78zgc:110782 [Source:ZFIN;Acc:ZDB-GENE-050320-51][more]
akr1b1.19.676e-3032.86aldo-keto reductase family 1, member B1 (aldose re... [more]
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BLAST of Aldo-keto reductase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
GRE31.814e-6037.26Aldose reductase; involved in methylglyoxal, d-xyl... [more]
GCY16.689e-5635.17Glycerol dehydrogenase; involved in an alternative... [more]
YPR18.601e-5334.22NADPH-dependent aldo-keto reductase; reduces multi... [more]
ARA17.209e-5236.21NADP+ dependent arabinose dehydrogenase; involved ... [more]
YJR096W_mRNA9.288e-4431.25Xylose and arabinose reductase; member of the aldo... [more]
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BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO451571.532e-7543.87Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO269533.057e-7543.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO364116.597e-7143.19Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO459406.045e-5134.93Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO396948.520e-4532.87Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Aldo-keto reductase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
akr1b1.13.685e-8143.91aldose reductase [Source:NCBI gene;Acc:101157264][more]
akr1a1a1.305e-7941.64alcohol dehydrogenase [NADP(+)] A-like [Source:NCB... [more]
akr1a1b5.087e-7844.07aldo-keto reductase family 1 member A1 [Source:NCB... [more]
AKR1D12.884e-7739.433-oxo-5-beta-steroid 4-dehydrogenase [Source:NCBI ... [more]
zgc:566226.050e-7740.32aldose reductase-related protein 2 [Source:NCBI ge... [more]
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BLAST of Aldo-keto reductase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000062723.10.000e+0100.00SMESG000062723.1[more]
SMESG000081151.16.730e-17175.48SMESG000081151.1[more]
SMESG000015779.11.243e-4131.54SMESG000015779.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008929 ID=SMED30008929|Name=Aldo-keto reductase|organism=Schmidtea mediterranea sexual|type=transcript|length=1115bp
AAATGAATAGTTTTAATAAACTGAAATAATTTATCTAATATATAACAGAC
CATTTGTTCTAAAATATTTCATTTAAATATGTTAACAGTTAAATTGAAAA
GCGGTCATGAAATGCCGATTTTTGGATTAGGCACTTGGCTGTCAAAGCCA
GGCGAAGTAAAGCTTGCGGTGGAAAACGCTTTAAATTTAGGCTATAAGCT
TATCGACTGTGCTTGGGCGTATTGCAACGAATCGGAAATCGGAGAAGTTT
TAGAAAGGTATATCAGCGGTGGTAAAGTTAAAAGAGAAGAACTGTTTGTA
ACTAGCAAGCTTTGGAATTCATTTCATAGACCAGAATTAGTCAAAGTTGG
ATTAGAAGAAACTTTGAGAAATTTGAAATTAAGTTATCTCGATTTGTTTT
TAATCCACACTCCAATATCTTACAAGCCAGGTAACCTTTTCCCGGATGCT
GATAAGTTTAAAGATGAAATTGAAGACGTCGATTTGGTAGAAACATGGAA
AGCAATGGAAAATTTGGTTGATTCGGGAAAGGTTCGATCAATCGGCGTGT
CAAATTTCAACATTAAACAAGTTCAAAATATTCTTGACCATAGTCGCATT
AAACCAGCAATGAATCAGGTTGAGGTGAATATTTATTTTCCCAATAAAAA
ACTTGTTGAATTTTGTTTGAAAAACGGCGTCCAAATCACTGCCTATTCTC
CACTCGGAGGAGCGCCAAATCGACCTATCGAGGGAGAAAAATTAAGAAGA
CCTTTGGAAGATCCGAAAGTTCTGGAGCTGGCTCAAAAATATAATGCGAC
AGCTGGGCAAATATTGATAACATATACAATTCATCGTGGTCTAGTTACGA
TTCCGAAAAGTGTATCTGCACTTAGATTGGAAGAAAATATCAAAGCGTTG
AATATTAAACTTACTGACGAAGACTTTCAAAAGCTAGATAGCCTAAATGT
CAACATCCGAATGTGTAATCCGGAACTGTTTAAGATGCACAAAAATTACC
CATTTGGAGAAGATTGATTGAAACAAATTTGATGAAACTTTTAATTGATA
TTTTTAGGATAAATTTATTCTTTGATAATTTTTAACGCGCCATTTTAATA
ATAAATTAAATTGAT
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protein sequence of SMED30008929-orf-1

>SMED30008929-orf-1 ID=SMED30008929-orf-1|Name=SMED30008929-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=313bp
MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCN
ESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLK
LSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSG
KVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNG
VQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYT
IHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPEL
FKMHKNYPFGED*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000034epidermis
Vocabulary: INTERPRO
TermDefinition
IPR036812NADP_OxRdtase_dom_sf
IPR020471Aldo/keto_reductase
IPR023210NADP_OxRdtase_dom
IPR018170Aldo/ket_reductase_CS
Vocabulary: biological process
TermDefinition
GO:0055114oxidation-reduction process
Vocabulary: molecular function
TermDefinition
GO:0016491oxidoreductase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR020471Aldo/keto reductasePRINTSPR00069ALDKETRDTASEcoord: 94..112
score: 55.6
coord: 34..58
score: 46.21
coord: 143..160
score: 58.63
coord: 177..206
score: 38.39
coord: 225..249
score: 32.85
IPR020471Aldo/keto reductasePIRSFPIRSF000097AKRcoord: 1..312
e-value: 3.5E-106
score: 352.3
IPR020471Aldo/keto reductasePANTHERPTHR11732ALDO/KETO REDUCTASEcoord: 3..300
IPR023210NADP-dependent oxidoreductase domainPFAMPF00248Aldo_ket_redcoord: 17..290
e-value: 6.6E-54
score: 183.1
IPR023210NADP-dependent oxidoreductase domainCDDcd06660Aldo_ket_redcoord: 3..289
e-value: 1.81504E-89
score: 266.732
IPR036812NADP-dependent oxidoreductase domain superfamilyGENE3DG3DSA:3.20.20.100coord: 1..312
e-value: 2.8E-116
score: 389.7
IPR036812NADP-dependent oxidoreductase domain superfamilySUPERFAMILYSSF51430NAD(P)-linked oxidoreductasecoord: 2..309
NoneNo IPR availablePANTHERPTHR11732:SF387coord: 3..300
IPR018170Aldo/keto reductase, conserved sitePROSITEPS00062ALDOKETO_REDUCTASE_2coord: 143..160
IPR018170Aldo/keto reductase, conserved sitePROSITEPS00063ALDOKETO_REDUCTASE_3coord: 258..273