Aldo-keto reductase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30008929 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1B10 (aldo-keto reductase family 1 member B10 [Source:HGNC Symbol;Acc:HGNC:382]) HSP 1 Score: 266.544 bits (680), Expect = 1.014e-86 Identity = 138/309 (44.66%), Postives = 199/309 (64.40%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
V+L + +MPI GLGTW S G+VK AV+ A++ GY+ IDCA+ Y NE E+GE ++ I VKRE+LF+ SKLW +F LV+ E+TL++LKLSYLD++LIH P +K G +LFP DK ++ W+AME LVD G V+++GVSNF+ Q++ +L+ + KP NQVE + Y +KL+++C G+ +TAYSPL G+P+RP + LEDPK+ E+A K+ TA Q+LI + I R ++ IPKSV+ R+ ENI+ + KL+DE+ + S N N R CN ++YPF
Sbjct: 5 VELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPL-GSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPF 312
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1B1 (aldo-keto reductase family 1 member B [Source:HGNC Symbol;Acc:HGNC:381]) HSP 1 Score: 251.906 bits (642), Expect = 5.362e-81 Identity = 140/310 (45.16%), Postives = 202/310 (65.16%), Query Frame = 1
Query: 94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEI-EDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
L +G +MPI GLGTW S PG+V AV+ A+++GY+ IDCA Y NE+E+G ++ + VKREELF+ SKLW ++H LVK ++TL +LKL YLDL+LIH P +KPG F D+ + + D ++++TW AME LVD G V++IG+SNFN QV+ IL+ + KPA+NQ+E + Y +KL+++C G+ +TAYSPL G+P+RP + LEDP++ +A K+N T Q+LI + + R LV IPKSV+ R+ EN K + +L+ +D L S N N R+C HK+YPF E+
Sbjct: 7 LNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEE 315
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1A1 (aldo-keto reductase family 1 member A1 [Source:HGNC Symbol;Acc:HGNC:380]) HSP 1 Score: 251.906 bits (642), Expect = 6.292e-81 Identity = 135/314 (42.99%), Postives = 197/314 (62.74%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGA------PNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYP 1002
V L +G +MP+ GLGTW S+PG+VK AV+ AL++GY+ IDCA Y NE EIGE L+ + GK V REELFVTSKLWN+ H PE V+ L +TL +L+L YLDL+L+H P +++ G N FP + ETWKA+E LV G V+++G+SNFN +Q+ +IL + ++PA+ QVE + Y +L+ C G+++TAYSPLG + P+ P+ LE+P VL LA+KY + QIL+ + + R ++ IPKS++ R+ +NIK + + E+ ++L++LN N R P L K P
Sbjct: 5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVL-------LEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVP 311
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1A1 (aldo-keto reductase family 1 member A1 [Source:HGNC Symbol;Acc:HGNC:380]) HSP 1 Score: 251.906 bits (642), Expect = 6.292e-81 Identity = 135/314 (42.99%), Postives = 197/314 (62.74%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGA------PNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYP 1002
V L +G +MP+ GLGTW S+PG+VK AV+ AL++GY+ IDCA Y NE EIGE L+ + GK V REELFVTSKLWN+ H PE V+ L +TL +L+L YLDL+L+H P +++ G N FP + ETWKA+E LV G V+++G+SNFN +Q+ +IL + ++PA+ QVE + Y +L+ C G+++TAYSPLG + P+ P+ LE+P VL LA+KY + QIL+ + + R ++ IPKS++ R+ +NIK + + E+ ++L++LN N R P L K P
Sbjct: 5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVL-------LEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVP 311
BLAST of Aldo-keto reductase vs. Ensembl Human
Match: AKR1A1 (aldo-keto reductase family 1 member A1 [Source:HGNC Symbol;Acc:HGNC:380]) HSP 1 Score: 251.906 bits (642), Expect = 6.292e-81 Identity = 135/314 (42.99%), Postives = 197/314 (62.74%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGA------PNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYP 1002
V L +G +MP+ GLGTW S+PG+VK AV+ AL++GY+ IDCA Y NE EIGE L+ + GK V REELFVTSKLWN+ H PE V+ L +TL +L+L YLDL+L+H P +++ G N FP + ETWKA+E LV G V+++G+SNFN +Q+ +IL + ++PA+ QVE + Y +L+ C G+++TAYSPLG + P+ P+ LE+P VL LA+KY + QIL+ + + R ++ IPKS++ R+ +NIK + + E+ ++L++LN N R P L K P
Sbjct: 5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVL-------LEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVP 311
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: Y39G8B.1 (pep chromosome:WBcel235:II:13970584:13972970:-1 gene:WBGene00012722.1 transcript:Y39G8B.1b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y39G8B.1) HSP 1 Score: 247.669 bits (631), Expect = 7.835e-80 Identity = 135/318 (42.45%), Postives = 188/318 (59.12%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLE------LAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-HKNYPFGED 1014
++KL SG+ +P GLGTW SKPGEV A++ A+ GY+ IDCA Y N+ E+GE L+ + GKVKREELF+TSK+WN+FH ++ L +L+LSY+DL LIH P Y G LFP + K DVD +ETWKA E +GK RSIG+SNF Q+Q + D + +KPA QVE++ YF KL EFC + G+ + YSPLG G R DP VL +A+ + T QI++ + + GL IPKSV+ R+ ENI ++ +L+ E+ Q +D +N R+ +P HK + F E+
Sbjct: 4 SLKLNSGYSIPAIGLGTWQSKPGEVAAAIKTAVAAGYRHIDCAHVYQNQKEVGEALKEILDEGKVKREELFITSKVWNTFHSEAKAHENIDIILSDLQLSYVDLMLIHWPQGYAEGAELFPAGENGKMRYSDVDYLETWKAFEAAQKAGKCRSIGLSNFTHSQIQRVWDAAEVKPACLQVELHPYFTQVKLREFCKEKGIVVVGYSPLGNP------GSAFFRKDGDPNVLTNEVVAGIAKAHGKTPAQIILRWFVDSGLSAIPKSVTPQRIIENISVIDFQLSAEEIQAIDGVNRGWRLVDPSPRDGDHKYFGFNEE 315
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: Y39G8B.1 (pep chromosome:WBcel235:II:13970789:13972970:-1 gene:WBGene00012722.1 transcript:Y39G8B.1a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y39G8B.1) HSP 1 Score: 246.899 bits (629), Expect = 1.821e-79 Identity = 135/318 (42.45%), Postives = 188/318 (59.12%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLE------LAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCN-PELFKMHKNYPFGED 1014
++KL SG+ +P GLGTW SKPGEV A++ A+ GY+ IDCA Y N+ E+GE L+ + GKVKREELF+TSK+WN+FH ++ L +L+LSY+DL LIH P Y G LFP + K DVD +ETWKA E +GK RSIG+SNF Q+Q + D + +KPA QVE++ YF KL EFC + G+ + YSPLG G R DP VL +A+ + T QI++ + + GL IPKSV+ R+ EN+ + +LT E+ K+D +N N R+ + + H + PF E+
Sbjct: 4 SLKLNSGYSIPAIGLGTWQSKPGEVAAAIKTAVAAGYRHIDCAHVYQNQKEVGEALKEILDEGKVKREELFITSKVWNTFHSEAKAHENIDIILSDLQLSYVDLMLIHWPQGYAEGAELFPAGENGKMRYSDVDYLETWKAFEAAQKAGKCRSIGLSNFTHSQIQRVWDAAEVKPACLQVELHPYFTQVKLREFCKEKGIVVVGYSPLGNP------GSAFFRKDGDPNVLTNEVVAGIAKAHGKTPAQIILRWFVDSGLSAIPKSVTPQRISENLAVFDFQLTAEEISKIDGINKNWRIVDLSQRDGDHPHCPFLEE 315
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: T08H10.1 (pep chromosome:WBcel235:V:4483459:4486543:1 gene:WBGene00020369.1 transcript:T08H10.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T08H10.1) HSP 1 Score: 247.284 bits (630), Expect = 2.101e-79 Identity = 134/321 (41.74%), Postives = 198/321 (61.68%), Query Frame = 1
Query: 73 LNMLTVKLKSGHEMPIFGLGTWLSKP-GEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK--PGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPI--------EGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYP 1002
+ + ++ L +G ++P+FGLGTW K E+ +A+ AL+ GY+LID A Y NE IG+VL YIS GK+KRE++FVTSKL + H PE V +E L+ L+L Y+DL+LIH P +K G+ P + + + ++ ++TW+A+E L GK++++GVSNF+ Q+Q + D + +KPA QVE +IY+P ++L C K GV +TAY+PL G+P R EG+ PL +P V +LA KY+ TA QILI + G+ TIPKSVS R+ ENI + KL+DED L+S+ R+ + H +P
Sbjct: 1 MTVDSIPLNTGAQLPLFGLGTWQVKDEAELTVALRAALDAGYRLIDTAHLYQNEHIIGKVLHEYISSGKLKREDIFVTSKLPFTAHAPEDVPKCVESQLKALQLEYIDLYLIHCPFPFKHQEGSFAPLMENGELAVTEIAHIDTWRALEKLYKEGKLKALGVSNFSCNQLQALYDAAEVKPANQQVECHIYWPQQELRALCKKLGVTVTAYAPL-GSPGRKAARPDGVWPEGD----PLLEPIVKQLAAKYHKTAAQILIRHLTQHGISTIPKSVSPDRIVENISTFDFKLSDEDMHTLNSIETRTRLFIADFAVKHPFFP 316
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: C07D8.6 (pep chromosome:WBcel235:X:7341509:7342780:1 gene:WBGene00015565.1 transcript:C07D8.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C07D8.6) HSP 1 Score: 200.675 bits (509), Expect = 1.552e-61 Identity = 113/320 (35.31%), Postives = 176/320 (55.00%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNR-----PIEGEKLR-----RPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
++KL +G EMP+ GLGTW S P EV AV+ A+ GY+LID A Y NE IG ++ + G VKREELF+T+K W P ++ GL E+L+ L+L Y+DL+L H P ++ ++ +EDV W+ + + +G +++GVSN+N Q+ L +QVE+++YFP V+FC K+ + +T+Y+ L G+P R P G+KL L+D VL LA+K + T Q+L+ Y + RG +PKS+ R++EN + + LT+ED KL+ + R+ + H F +
Sbjct: 7 SIKLSNGVEMPVIGLGTWQSSPAEVITAVKTAVKAGYRLIDTASVYQNEEAIGTAIKELLEEGVVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFNDDM----SEHIASPVEDV-----WRQFDAVYKAGLAKAVGVSNWNNDQISRALALGLTPVHNSQVELHLYFPQHDHVDFCKKHNISVTSYATL-GSPGRVNFTLPT-GQKLDWAPAPSDLQDQNVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTEEDIAKLEESKNSQRLFLQDFMTGHPEDAFAAE 315
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Match: Y39G8B.2 (pep chromosome:WBcel235:II:13973690:13976221:-1 gene:WBGene00012723.1 transcript:Y39G8B.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y39G8B.2) HSP 1 Score: 197.208 bits (500), Expect = 6.380e-60 Identity = 111/320 (34.69%), Postives = 178/320 (55.62%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK----PG--NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVL------ELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-HKNYPF 1005
TV L SG+EMP+ G GTW V +AL GY+ ID A ++ N+ E+ ++ + KV+REELF++SK+WN++H ++E L + +Y+DL +IH P + PG L+P K DVD +ETWKA+E+ SGK+RSIG++NFNI QV+ + IKPA+ QVE+N + +++ +FC + G+ +TA+ L G P G L R EDP +L +A+ + + Q+L+ + I + KS + R+ +NI +LT ++ ++ +LN++ R+ NP L H +P+
Sbjct: 6 TVTLNSGYEMPVIGYGTWQLPKNLAAERVRDALEAGYRHIDSALSFKNQEEVAAGIKDWCKIRKVRREELFLSSKIWNTYHSRNRCMQQIDEMLEIFETTYMDLIVIHWPFGWAEDEPPGERGLWPRGANGKMRYSDVDYLETWKALEDAHRSGKIRSIGLANFNIGQVEQVWTKGLIKPAVLQVEMNPFLDQEEIRQFCREKGIILTAFM-LTGNP-----GSALYRKHEDPNLLYNETLQSIAKGHGKSVVQVLVRWAIDLRTTALVKSSESKRIRQNINIFKFRLTSQEIARIKALNIDFRILNPLLGNYDHPYFPW 319
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6083 (gene:FBgn0036183 transcript:FBtr0076137) HSP 1 Score: 254.988 bits (650), Expect = 1.464e-82 Identity = 126/308 (40.91%), Postives = 193/308 (62.66%), Query Frame = 1
Query: 94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG--NLFPDA-DKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKAL-NIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
L +G MP+ GLGTW S P V AV++A+++GY+ DCA Y NE+++G L + G V R+ELF+TSKLWN+ H+P+LV+ E ++RNL + YL+L+L+H P++YK G NL+P D K ED+D V+TW+AMENLVD G ++IGVSNFN +Q+ +L +++KP + Q+E + Y K L+ C N + +TAYS LG + P E L+ P +L +A+KY TA Q+L+ + G++ IP+SVS + +N K + + +L +D Q ++ L+ N R + H ++PF
Sbjct: 8 LSNGKNMPMLGLGTWRSPPEVVTQAVKDAIDIGYRHFDCAHIYGNEAQVGAALREKMDEGVVTRDELFITSKLWNTHHKPDLVRPACETSIRNLGVKYLNLYLMHWPMAYKSGSDNLYPTCPDTNKAAFEDIDYVDTWRAMENLVDEGLCQAIGVSNFNEQQMNRLLSVAKLKPVVLQIECHPYLSQKPLITLCYDNAIAVTAYSCLGSG-HTPYEKPGAYPLLQHPTILAIAEKYERTAAQVLLRFQTQSGIIVIPRSVSKQHMLDNFKRIWDFELAVDDIQAINELDCNGRFMTMKAAYGHPHHPF 314
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6084 (gene:FBgn0086254 transcript:FBtr0331547) HSP 1 Score: 249.21 bits (635), Expect = 2.775e-80 Identity = 153/313 (48.88%), Postives = 204/313 (65.18%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---MHKNYPFGED 1014
VK +G E+PI GLGTW S G+V AV+ A++ GY+ IDCA+ Y NE E+G+ +E I G VKRE+LF+TSKLWN+FHRP+LVK LE TL +LKL YLDL+LIH P+ YK G +LFP K VD V+TWKAME LV+ G V+SIGVSNFN +Q++ +L+ + I P NQ+E + Y KKL++FC + ITAYSPL G+PNRP LE+ K+ E+A K T GQILI Y + R + IPKSV+ R+E N + + +LT E+ + ++S N R+ L K HK YPF ++
Sbjct: 6 VKFNNGKEVPIIGLGTWGSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDITITAYSPL-GSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLV--PLLKDAGTHKYYPFHDE 315
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6084 (gene:FBgn0086254 transcript:FBtr0076139) HSP 1 Score: 247.284 bits (630), Expect = 1.248e-79 Identity = 152/311 (48.87%), Postives = 205/311 (65.92%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-HKNYPFGED 1014
VK +G E+PI GLGTW S G+V AV+ A++ GY+ IDCA+ Y NE E+G+ +E I G VKRE+LF+TSKLWN+FHRP+LVK LE TL +LKL YLDL+LIH P+ YK G +LFP K VD V+TWKAME LV+ G V+SIGVSNFN +Q++ +L+ + I P NQ+E + Y KKL++FC + ITAYSPL G+PNRP LE+ K+ E+A K T GQILI Y + R + IPKSV+ R+E N + + +LT E+ + ++S N R+ P L + H ++PF +D
Sbjct: 6 VKFNNGKEVPIIGLGTWGSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDITITAYSPL-GSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLV-PLLNQYGHPHHPFEKD 314
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6084 (gene:FBgn0086254 transcript:FBtr0076138) HSP 1 Score: 241.891 bits (616), Expect = 5.656e-77 Identity = 149/308 (48.38%), Postives = 202/308 (65.58%), Query Frame = 1
Query: 103 GHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---MHKNYPFGED 1014
G+E+P+ GLGT+ S G+V AV+ A++ GY+ IDCA+ Y NE E+G+ +E I G VKRE+LF+TSKLWN+FHRP+LVK LE TL +LKL YLDL+LIH P+ YK G +LFP K VD V+TWKAME LV+ G V+SIGVSNFN +Q++ +L+ + I P NQ+E + Y KKL++FC + ITAYSPL G+PNRP LE+ K+ E+A K T GQILI Y + R + IPKSV+ R+E N + + +LT E+ + ++S N R+ L K HK YPF ++
Sbjct: 45 GNEIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDITITAYSPL-GSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLV--PLLKDAGTHKYYPFHDE 349
BLAST of Aldo-keto reductase vs. Ensembl Fly
Match: CG6084 (gene:FBgn0086254 transcript:FBtr0331546) HSP 1 Score: 239.965 bits (611), Expect = 2.615e-76 Identity = 148/306 (48.37%), Postives = 203/306 (66.34%), Query Frame = 1
Query: 103 GHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-HKNYPFGED 1014
G+E+P+ GLGT+ S G+V AV+ A++ GY+ IDCA+ Y NE E+G+ +E I G VKRE+LF+TSKLWN+FHRP+LVK LE TL +LKL YLDL+LIH P+ YK G +LFP K VD V+TWKAME LV+ G V+SIGVSNFN +Q++ +L+ + I P NQ+E + Y KKL++FC + ITAYSPL G+PNRP LE+ K+ E+A K T GQILI Y + R + IPKSV+ R+E N + + +LT E+ + ++S N R+ P L + H ++PF +D
Sbjct: 45 GNEIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDITITAYSPL-GSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLV-PLLNQYGHPHHPFEKD 348
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1a1a (aldo-keto reductase family 1, member A1a (aldehyde reductase) [Source:NCBI gene;Acc:445326]) HSP 1 Score: 272.707 bits (696), Expect = 2.518e-89 Identity = 143/322 (44.41%), Postives = 204/322 (63.35%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVL-ERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRP--IEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---------MHKNYPFGE 1011
T+ L +G MP GLGTW S PG+VK AV AL+ GY+ IDCA AY NE E+GE L ER G ++R+++FVTSKLWN+ H P+ V+ +L +L+LSYLDL+LIH P+++ G+ L P + +D +TW AME LVD G ++IG+SNFN KQ+ +IL ++ KP +NQVE + Y +LV C + +TAYSPL G+P+RP GE L L+DP+V+ +A+ YN T Q++I + I RG+V IPKSV+ R+++NI+ + KL+DED + ++S N N R P + K H ++PF E
Sbjct: 4 TITLSTGQRMPTVGLGTWKSAPGQVKQAVLAALDCGYRHIDCAAAYSNEREVGEALTERLGPGKSLRRDDIFVTSKLWNTKHHPDDVEEACRRSLSDLRLSYLDLYLIHWPMAFGRGDELIPRHPDGTIQYDDTHYRDTWAAMEKLVDQGLAKAIGLSNFNAKQIDDILSIAKHKPVVNQVECHPYLVQAELVSHCWSRNLTVTAYSPL-GSPDRPWVTPGEALL--LDDPRVVGIAKSYNKTPAQVIIRWHIQRGVVCIPKSVTPSRIKQNIEVFDFKLSDEDMRLIESFNRNERFIIPTVIKDGQKIWRDAKHPHFPFIE 322
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1a1a (aldo-keto reductase family 1, member A1a (aldehyde reductase) [Source:NCBI gene;Acc:445326]) HSP 1 Score: 272.322 bits (695), Expect = 3.602e-89 Identity = 143/322 (44.41%), Postives = 204/322 (63.35%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVL-ERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRP--IEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---------MHKNYPFGE 1011
T+ L +G MP GLGTW S PG+VK AV AL+ GY+ IDCA AY NE E+GE L ER G ++R+++FVTSKLWN+ H P+ V+ +L +L+LSYLDL+LIH P+++ G+ L P + +D +TW AME LVD G ++IG+SNFN KQ+ +IL ++ KP +NQVE + Y +LV C + +TAYSPL G+P+RP GE L L+DP+V+ +A+ YN T Q++I + I RG+V IPKSV+ R+++NI+ + KL+DED + ++S N N R P + K H ++PF E
Sbjct: 4 TITLSTGQRMPTVGLGTWKSAPGQVKQAVLAALDCGYRHIDCAAAYSNEREVGEALTERLGPGKSLRRDDIFVTSKLWNTKHHPDDVEEACRRSLSDLRLSYLDLYLIHWPMAFGRGDELIPRHPDGTIQYDDTHYRDTWAAMEKLVDQGLAKAIGLSNFNAKQIDDILSIAKHKPVVNQVECHPYLVQAELVSHCWSRNLTVTAYSPL-GSPDRPWVTPGEALL--LDDPRVVGIAKSYNKTPAQVIIRWHIQRGVVCIPKSVTPSRIKQNIEVFDFKLSDEDMRLIESFNRNERFIIPTVIKDGQKIWRDANHPHFPFIE 322
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1b1.1 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-040625-7]) HSP 1 Score: 263.077 bits (671), Expect = 1.313e-85 Identity = 141/313 (45.05%), Postives = 201/313 (64.22%), Query Frame = 1
Query: 79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIED-VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
M +V L +G +MPI GLGTW S PGEV AV++A+ GY+ ID A Y NE+E+G+ + I+ G VKR++LF+ SKLW +FH LV+ E+TL +LKL Y+DL+L+H P+ KPG +LFP DK I D + +ETW+AME LVD+G V++IG+SNFN Q++ IL+ + KPA NQ+E + Y +KL+ +C G+ +TAYSPL G+PNRP LEDPK+ +A K+ T Q+LI + I R +V IPKSV+ R++EN + + +L+ E+ + S N N R E HK++P
Sbjct: 1 MTSVTLNNGAKMPIVGLGTWRSPPGEVTEAVKSAILSGYRHIDGAHVYENENEVGDGICAMINQGVVKRKDLFIVSKLWCTFHEKHLVRGACEKTLSDLKLDYVDLYLMHFPMGTKPGKDLFP-LDKDGHVIPDNSNFLETWEAMEELVDAGLVKAIGISNFNRDQIEAILNKPGLKYKPANNQIECHPYLTQEKLINYCQSKGITVTAYSPL-GSPNRPWAQADEPSLLEDPKIKAIADKHGKTTAQVLIHFHIQRNVVVIPKSVTPSRIKENFEVFDFELSKEEMNTILSFNRNFRAFGLEWASKHKDFPL 311
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1b1.1 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-040625-7]) HSP 1 Score: 256.914 bits (655), Expect = 2.091e-83 Identity = 137/298 (45.97%), Postives = 195/298 (65.44%), Query Frame = 1
Query: 79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIED-VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIR 960
M +V L +G +MPI GLGTW S PGEV AV++A+ GY+ ID A Y NE+E+G+ + I+ G VKR++LF+ SKLW +FH LV+ E+TL +LKL Y+DL+L+H P+ KPG +LFP DK I D + +ETW+AME LVD+G V++IG+SNFN Q++ IL+ + KPA NQ+E + Y +KL+ +C G+ +TAYSPL G+PNRP LEDPK+ +A K+ T Q+LI + I R +V IPKSV+ R++EN + + +L+ E+ + S N N R
Sbjct: 1 MTSVTLNNGAKMPIVGLGTWRSPPGEVTEAVKSAILSGYRHIDGAHVYENENEVGDGICAMINQGVVKRKDLFIVSKLWCTFHEKHLVRGACEKTLSDLKLDYVDLYLMHFPMGTKPGKDLFP-LDKDGHVIPDNSNFLETWEAMEELVDAGLVKAIGISNFNRDQIEAILNKPGLKYKPANNQIECHPYLTQEKLINYCQSKGITVTAYSPL-GSPNRPWAQADEPSLLEDPKIKAIADKHGKTTAQVLIHFHIQRNVVVIPKSVTPSRIKENFEVFDFELSKEEMNTILSFNRNFR 296
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Match: akr1b1.2 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-041210-132]) HSP 1 Score: 248.825 bits (634), Expect = 1.267e-79 Identity = 136/310 (43.87%), Postives = 200/310 (64.52%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
+VKL +G +MPI GLGTW S PG+V AV+ A+ GY+ ID A Y NE+E+GE ++ I G VKREELFV SKLW +FH LVK ++TL +L L YLDL+LIH P+ +K G+ FP + +D ++TW+AME LVD+G V++IG+SNFN +Q++ IL+ + KPA NQVE + Y KL+ +C G+ +TAYSPL G+P+RP + L+DP + +A+K+ T Q+LI + I R ++ IPKS++ R++EN + + +L+++D + + S N N R C H++YPF
Sbjct: 32 SVKLNTGADMPILGLGTWKSPPGKVTEAVKAAIAAGYRHIDGAAVYNNETEVGEGIKAMIKDGVVKREELFVVSKLWCTFHEKALVKGACQKTLSDLNLDYLDLYLIHWPMGFKSGSEQFPLDSEGLTIGDDSSFLDTWEAMEELVDAGLVKAIGISNFNREQIEAILNKPGLKYKPANNQVECHPYLTQDKLISYCQSKGITVTAYSPL-GSPDRPWAKPEDPSLLDDPNIKAIAEKHKKTTAQVLIRFQIQRNVIVIPKSITPQRIQENFQVFDFELSEQDMKTILSFNRNFRACPMHWGVKHRDYPF 340
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: akr1b1 (aldo-keto reductase family 1, member B1 (aldose reductase) [Source:NCBI gene;Acc:496546]) HSP 1 Score: 254.988 bits (650), Expect = 3.038e-82 Identity = 137/309 (44.34%), Postives = 208/309 (67.31%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
V+L +G +MPI GLGTW S+PG+V AV A+ +GY+ +DCA+ Y NE+E+GE +++ I G VKRE+LFV SKLW++FH +VK ++TL +LKL YLDL+L+H P ++ G+ LFP ++ + ++TW+ ME LVD+G V++IG+SNFN +Q++ +L+ + KPA++Q E + Y KKL++ C G+ +TAYSPL G+P+RP + LE+PK+ E+A+KYN T+ Q+LI + I R +V IPKSV+ R+EEN + + +L+ ED + + S R+C K HK+YPF
Sbjct: 7 VQLYTGAQMPIVGLGTWKSEPGKVTAAVAKAIEVGYRHLDCAYVYQNENEVGEGIQQKIKEGLVKREDLFVVSKLWSTFHDKSMVKGACQKTLSDLKLDYLDLYLVHWPTGFQAGDALFPLDNEGCVIHSNTHFLDTWEGMEELVDAGLVKAIGISNFNREQIEQLLNKPGLKHKPAVHQFECHPYLTQKKLIDLCQSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEEPKIKEIAKKYNKTSAQVLIRFHIQRNVVVIPKSVTPARIEENFQVFDFELSPEDTEAIFSFERGWRVCALSSAKKHKDYPF 314
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: akr1c2 (aldo-keto reductase family 1, member C2 [Source:NCBI gene;Acc:779650]) HSP 1 Score: 239.58 bits (610), Expect = 3.812e-76 Identity = 127/315 (40.32%), Postives = 189/315 (60.00%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENA---LNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKP-GNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
V L G+ MP+ G GT+ + LA E A +++GY+ ID A+ Y NE+E+G + I+ G VKRE+LF T KLW+SFH PE V+ G E++L++L+L Y+DLF+IH P+ +KP N FP + K + DL +TWKAME L D G V+SIGVSNFN +Q++ IL + KP NQVE +IY KL+EFC + + YS LG + + + LEDP + +A+K N T Q+ + Y + RG+V + KS + R+++N + + +L E+ + LD +N N+R + + H YPF +D
Sbjct: 9 VLLNDGNRMPVIGYGTYAPQNVPKHLAEEGAKVAIDVGYRHIDSAFMYLNEAEVGRAINAKIADGTVKREDLFYTGKLWSSFHTPERVRQGFEKSLKDLQLDYMDLFIIHLPVEFKPEDNPFPVDENGKFLYHNTDLRDTWKAMEALKDEGLVKSIGVSNFNKRQLELILSMPGLKYKPVCNQVECHIYLNQSKLLEFCKSKDIVLVGYSVLGSSRDEQWIDQNSPVVLEDPVLNAIAKKLNRTPAQVAMRYLLQRGVVILAKSFTPARIQQNFQIFDFQLNAEEMKTLDGVNKNLRYLDLKQLADHPKYPFADD 323
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: tm4sf5 (transmembrane 4 L six family member 5 [Source:Xenbase;Acc:XB-GENE-969431]) HSP 1 Score: 238.424 bits (607), Expect = 8.473e-76 Identity = 128/317 (40.38%), Postives = 194/317 (61.20%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEV--KLAVEN---ALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
V L GH+MP+ G GT++ PG++ LA E A+++GY+ ID A+ Y NE E+G + I+ G VKRE++F T KLW +FH PE V+V L+++L++L+L YLDLF+IH P+ +KPG + P + K + DL +TWKA+E D+G VRSIGVSNFN KQ++ IL+ + KP NQVE +IY KL+EFC + + AY LG ++ + LE+ + +A+K+N T + + Y + RG+V + KS + R++EN K N +L DED + +D +N ++R + + H YPF E+
Sbjct: 9 VVLNDGHKMPVLGFGTFV--PGKLPKSLAEEGTKVAIDVGYRHIDSAFFYGNEVEVGRAIRAKIADGTVKREDVFYTGKLWCTFHTPERVRVCLDKSLKDLQLDYLDLFIIHIPVEFKPGDDPLPVDENGKCIFHNTDLRDTWKALEKCKDAGLVRSIGVSNFNHKQLELILNMPGLKYKPVCNQVECHIYLNQSKLLEFCKSKDIVLVAYGVLGSTRDKKWIDQSTPFLLENAVLNAIAKKHNCTPAHVAMRYLLQRGVVVLAKSFNPARIKENFKVFNFQLDDEDMKTIDEINRDLRYLDITAWSDHPKYPFHEE 323
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: akr1c8p (aldo-keto reductase family 1, member C8, pseudogene [Source:NCBI gene;Acc:448368]) HSP 1 Score: 237.269 bits (604), Expect = 2.963e-75 Identity = 123/316 (38.92%), Postives = 190/316 (60.13%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVEN---ALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
++L GH+MP+ G GT+ + LA E A+++GY+ ID A+ Y NE E+G + I+ G VKRE++F T KLW++FH PE V+ LE++L +L+L Y+DLF+IH P+ KPG + P + K + D+ +TWKA+E D+G VRSIGVSNFN KQ++ IL+ + KP NQVE ++Y KL+EFC + + A+ LG + + L LEDP + +A+K+N T Q+ + Y + RG+V + KS + R+++N + N+ L ED + +D +N N+R ++ H YPF E+
Sbjct: 8 CIELNDGHKMPVLGFGTYAPQKFPKSLAEEGTKVAIDVGYRHIDSAFFYGNEVEVGRAIRAKIADGTVKREDVFYTGKLWSTFHTPERVRPALEKSLNDLQLDYMDLFIIHIPVELKPGDDPLPLDENGKFIYHNTDIRDTWKALEKCKDAGLVRSIGVSNFNHKQLELILNMPGLKYKPVCNQVECHVYLNQSKLLEFCKSKDIVLVAFGVLGSSRDESWIDPNLPVLLEDPVLNAIAKKHNCTPAQVAMRYLLQRGVVVLVKSFTPARIQQNFQVFNVHLDAEDMRNVDGINRNLRYDYAPMWSDHPKYPFHEE 323
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Match: nudt2 (nudix hydrolase 2 [Source:Xenbase;Acc:XB-GENE-1008721]) HSP 1 Score: 236.113 bits (601), Expect = 3.013e-75 Identity = 120/285 (42.11%), Postives = 183/285 (64.21%), Query Frame = 1
Query: 178 ALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPN-RPIEGEKLRRP--LEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
A+++GY+ IDCA+ Y +E E+G + I+ G VKRE++F T KLW++FH PE V+V LE++L++L+L Y+DLF+IH P+ +KPG +LFP + K + DL +TWKA+E D+G VRSIGVSNFN KQ++ IL+ + KP NQVE ++Y KL+EFC + + YS LG + + R IE P LEDP + E+A+K+N T Q+ + Y + RG+V + KS + R+++N + + +L ED + +D LN N+R + + H YP+ E+
Sbjct: 15 AIDVGYRHIDCAFIYGSEVEVGRAIGAKIADGTVKREDVFYTGKLWSTFHTPERVRVCLEKSLKDLQLDYMDLFIIHNPMEFKPGDDLFPADENGKFIYHNTDLRDTWKALEKCKDAGLVRSIGVSNFNHKQLELILNMPGLKYKPVCNQVECHVYLNQSKLLEFCKSKDIVLVGYSVLGSSRDERWIEASA---PVLLEDPTLTEIAKKHNRTPAQVAMRYHLQRGVVVLAKSFTPARIQQNFQVFDFQLDAEDMRSIDGLNRNMRYIDTSRWSDHPKYPYSEE 296
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1b3 (aldo-keto reductase family 1, member B3 (aldose reductase) [Source:MGI Symbol;Acc:MGI:1353494]) HSP 1 Score: 258.07 bits (658), Expect = 1.032e-83 Identity = 142/309 (45.95%), Postives = 200/309 (64.72%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEI-EDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
++L +G +MP GLGTW S PG+V AV+ A++LGY+ IDCA Y NE E+G L+ + VKR++LF+ SKLW +FH +VK ++TL +L+L YLDL+LIH P +KPG + D + I D D V+TW AME LVD G V++IGVSNFN Q++ IL+ + KPA+NQ+E + Y +KL+E+C G+ +TAYSPL G+P+RP + LEDP++ +A KYN T Q+LI + I R LV IPKSV+ +R+ EN+K + +++ ED L S N N R+C HK+YPF
Sbjct: 5 LELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYPF 312
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1a1 (aldo-keto reductase family 1, member A1 (aldehyde reductase) [Source:MGI Symbol;Acc:MGI:1929955]) HSP 1 Score: 253.062 bits (645), Expect = 1.686e-81 Identity = 129/304 (42.43%), Postives = 196/304 (64.47%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGA------PNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNP 972
+V L +G +MP+ GLGTW S+PG+VK A+++AL+ GY+ IDCA Y NE+EIGE L+ + GK V REELFVTSKLWN+ H PE V+ L +TL +L+L YLDL+L+H P +++ G N FP + ETWKA+E LV G V+++G+SNFN +Q+ ++L + ++PA+ QVE + Y +L+ C G+++TAYSPLG + P+ P+ LE+P VL LA+K+ + QIL+ + + R ++ IPKS++ R+ +NI+ + + E+ ++LD+LN N R P
Sbjct: 5 SVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVL-------LEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1b8 (aldo-keto reductase family 1, member B8 [Source:MGI Symbol;Acc:MGI:107673]) HSP 1 Score: 245.743 bits (626), Expect = 9.248e-79 Identity = 137/310 (44.19%), Postives = 201/310 (64.84%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMC-NPELFKMHKNYPF 1005
V+L + +MPI GLGTW S P +VK AV+ A++ GY+ IDCA+AYCNE+E+GE ++ I V+RE+LF+ SKLW + +L+K ++TL +LKL YLDL+LIH P +PG LFP D+ + +E W+ ME LVD G V+++GVSNFN Q++ +L+ + KP NQVE + Y +KL+++C G+ +TAYSPL G+P+RP + LEDPK+ E+A K+ T+ Q+LI + I R +V IPKSV+ R++ENI+ + +L+DE+ + S N N R C PE M + YP+
Sbjct: 5 VELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQEKIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGISVTAYSPL-GSPDRPSAKPEDPSLLEDPKIKEIAAKHEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACLLPETVNM-EEYPY 312
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1b10 (aldo-keto reductase family 1, member B10 (aldose reductase) [Source:MGI Symbol;Acc:MGI:1915111]) HSP 1 Score: 243.432 bits (620), Expect = 5.563e-78 Identity = 137/309 (44.34%), Postives = 198/309 (64.08%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLF-PDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
V L +G +MPI GLGTW S P +V+ AV+ A++ GY+ IDCA+ Y NESE+GE ++ I VKRE+LF+ SKLW++F LVK + TL +LKL YLDL+LIH P ++ GN+F P DK ++ W+AME LVD G V+++GVSNFN Q++ +L+ + KP NQVE + Y +KL+++C G+ ITAYSPL G+P+RP + LE PK+ E+A K+ TA Q+LI + I R +V IPKSV+ R++ENI+ + +L++ED + S N N R C ++++PF
Sbjct: 5 VTLLTGAKMPIVGLGTWKSPPAKVREAVKVAIDAGYRHIDCAYVYQNESEVGEAIQEKIQEKAVKREDLFIVSKLWSTFFEKSLVKKAFQNTLSDLKLDYLDLYLIHWPQGFQSGNVFLPTDDKGSILSSKYTFLDAWEAMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGITITAYSPL-GSPDRPSAKPEDPLLLEIPKIKEIAAKHKRTAAQVLIRFHIERNVVVIPKSVTPSRIQENIQVFDFQLSEEDMAAILSFNRNWRACGLFAASHNEDFPF 312
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Match: Akr1c6 (aldo-keto reductase family 1, member C6 [Source:MGI Symbol;Acc:MGI:1933427]) HSP 1 Score: 243.817 bits (621), Expect = 6.461e-78 Identity = 131/318 (41.19%), Postives = 193/318 (60.69%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEV-----KLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
TV+L GH +PI G GT+ P EV A + A++ G++ ID A Y NE E+G + I+ G VKRE++F TSK+W +FHRPELV+V LE++L+ L+L Y+DL+LIH P++ KPG N P + K + VD+ +TW+AME D+G +SIGVSNFN +Q++ IL + KP NQVE + Y KL++FC + + AYS LG + + L++P + +A+KYN T I + Y + RG+V + KS S R++EN++ +LT ED + LD LN NIR + FK H ++PF ++
Sbjct: 7 TVRLSDGHFIPILGFGTY--APQEVPKSKATEATKIAIDAGFRHIDSASMYQNEKEVGLAIRSKIADGTVKREDIFYTSKVWCTFHRPELVRVCLEQSLKQLQLDYVDLYLIHFPMAMKPGENYLPKDENGKLIYDAVDICDTWEAMEKCKDAGLAKSIGVSNFNRRQLEKILKKPGLKYKPVCNQVECHPYLNQGKLLDFCRSKDIVLVAYSALGSHREKQWVDQSSPVLLDNPVLGSMAKKYNRTPALIALRYQLQRGVVVLAKSFSEKRIKENMQVFEFQLTSEDMKVLDDLNKNIRYISGSSFKDHPDFPFWDE 322
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|Q6AZW2|A1A1A_DANRE (Aldo-keto reductase family 1 member A1-A OS=Danio rerio OX=7955 GN=akr1a1a PE=2 SV=2) HSP 1 Score: 272.707 bits (696), Expect = 1.901e-88 Identity = 143/322 (44.41%), Postives = 204/322 (63.35%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVL-ERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRP--IEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---------MHKNYPFGE 1011
T+ L +G MP GLGTW S PG+VK AV AL+ GY+ IDCA AY NE E+GE L ER G ++R+++FVTSKLWN+ H P+ V+ +L +L+LSYLDL+LIH P+++ G+ L P + +D +TW AME LVD G ++IG+SNFN KQ+ +IL ++ KP +NQVE + Y +LV C + +TAYSPL G+P+RP GE L L+DP+V+ +A+ YN T Q++I + I RG+V IPKSV+ R+++NI+ + KL+DED + ++S N N R P + K H ++PF E
Sbjct: 4 TITLSTGQRMPTVGLGTWKSAPGQVKQAVLAALDCGYRHIDCAAAYSNEREVGEALTERLGPGKSLRRDDIFVTSKLWNTKHHPDDVEEACRRSLSDLRLSYLDLYLIHWPMAFGRGDELIPRHPDGTIQYDDTHYRDTWAAMEKLVDQGLAKAIGLSNFNAKQIDDILSIAKHKPVVNQVECHPYLVQAELVSHCWSRNLTVTAYSPL-GSPDRPWVTPGEALL--LDDPRVVGIAKSYNKTPAQVIIRWHIQRGVVCIPKSVTPSRIKQNIEVFDFKLSDEDMRLIESFNRNERFIIPTVIKDGQKIWRDAKHPHFPFIE 322
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|O60218|AK1BA_HUMAN (Aldo-keto reductase family 1 member B10 OS=Homo sapiens OX=9606 GN=AKR1B10 PE=1 SV=2) HSP 1 Score: 266.544 bits (680), Expect = 4.869e-86 Identity = 138/309 (44.66%), Postives = 199/309 (64.40%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
V+L + +MPI GLGTW S G+VK AV+ A++ GY+ IDCA+ Y NE E+GE ++ I VKRE+LF+ SKLW +F LV+ E+TL++LKLSYLD++LIH P +K G +LFP DK ++ W+AME LVD G V+++GVSNF+ Q++ +L+ + KP NQVE + Y +KL+++C G+ +TAYSPL G+P+RP + LEDPK+ E+A K+ TA Q+LI + I R ++ IPKSV+ R+ ENI+ + KL+DE+ + S N N R CN ++YPF
Sbjct: 5 VELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPL-GSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPF 312
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|P07943|ALDR_RAT (Aldo-keto reductase family 1 member B1 OS=Rattus norvegicus OX=10116 GN=Akr1b1 PE=1 SV=3) HSP 1 Score: 258.455 bits (659), Expect = 6.548e-83 Identity = 143/309 (46.28%), Postives = 200/309 (64.72%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEI-EDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
++L +G +MP GLGTW S PG+V AV+ A+++GY+ IDCA Y NE E+G L+ + VKR++LF+ SKLW +FH +VK ++TL +L+L YLDL+LIH P +KPG + D + I D D V+TW AME LVD G V++IGVSNFN Q++ IL+ + KPA+NQ+E + Y +KL+E+C G+ +TAYSPL G+P+RP + LEDP++ E+A KYN T Q+LI + I R LV IPKSV+ R+ EN K + +L++ED L S N N R+C HK+YPF
Sbjct: 5 LELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPF 312
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|P45376|ALDR_MOUSE (Aldo-keto reductase family 1 member B1 OS=Mus musculus OX=10090 GN=Akr1b1 PE=1 SV=3) HSP 1 Score: 258.07 bits (658), Expect = 7.218e-83 Identity = 142/309 (45.95%), Postives = 200/309 (64.72%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEI-EDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
++L +G +MP GLGTW S PG+V AV+ A++LGY+ IDCA Y NE E+G L+ + VKR++LF+ SKLW +FH +VK ++TL +L+L YLDL+LIH P +KPG + D + I D D V+TW AME LVD G V++IGVSNFN Q++ IL+ + KPA+NQ+E + Y +KL+E+C G+ +TAYSPL G+P+RP + LEDP++ +A KYN T Q+LI + I R LV IPKSV+ +R+ EN+K + +++ ED L S N N R+C HK+YPF
Sbjct: 5 LELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYPF 312
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Match: sp|P80276|ALDR_PIG (Aldo-keto reductase family 1 member B1 OS=Sus scrofa OX=9823 GN=AKR1B1 PE=1 SV=2) HSP 1 Score: 256.529 bits (654), Expect = 2.886e-82 Identity = 151/313 (48.24%), Postives = 204/313 (65.18%), Query Frame = 1
Query: 94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFP---DADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
L +G +MPI GLGTW S PG+V AV+ A++LGY+ IDCA Y NE+E+G L+ + G VKRE+LF+ SKLW + H LVK + TLR+LKL YLDL+LIH P +KPG + FP D + DE D VETW+AME LVD G V++IGVSNFN QV+ IL+ + KPA+NQ+EV+ Y +KL+E+C G+ +TAYSPL G+P+RP + LEDP++ +A KYN T Q+LI + + R L+ IPKSV+ R+ EN + + +L+ ED L S N N R+C HK+YPF E+
Sbjct: 7 LYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLDGDGNVVPDE---SDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPL-GSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCALMSCASHKDYPFHEE 315
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A026WTR5 (Aldo-keto reductase family 1 member B10 OS=Ooceraea biroi OX=2015173 GN=X777_15999 PE=4 SV=1) HSP 1 Score: 317.39 bits (812), Expect = 1.744e-103 Identity = 153/313 (48.88%), Postives = 216/313 (69.01%), Query Frame = 1
Query: 73 LNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFG 1008
LN VK +G+E+P+FGLGTW SKPGEV AV++A+++GY+ +DCA+ Y NE E+G ++ I+ G VKRE+LF+TSKLWN+FH+P+LV+ L++TL N LSY+DL+LIH P+ YK G +LFP + + DVD V+TWKAMEN++ G ++IGVSNFN +Q+ +L+++++KP NQVE + Y KKL +FC K + ITAYSPL G+P+RP + LED K++ELAQKYN T Q+LI Y + RG + IPKSV+ R+ +N + + KL+ ED +DS + N R+C YPFG
Sbjct: 3 LNAPKVKFYNGNEIPVFGLGTWKSKPGEVTQAVKDAIDIGYRHLDCAYVYGNEKEVGMAIQEKIADGTVKREDLFITSKLWNTFHKPDLVESALKQTLTNFGLSYIDLYLIHWPVGYKDGESLFPTTPEGTTALSDVDYVDTWKAMENVLSKGLTKNIGVSNFNSEQITRLLENAKVKPVTNQVECHPYLTQKKLSDFCKKKDILITAYSPL-GSPDRPWAKPDDPKLLEDTKLIELAQKYNKTPAQVLIRYQLDRGHIVIPKSVTKSRIAQNSQVFDFKLSPEDIAYIDSFDCNGRICPLLGADASPYYPFG 314
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A1J1IMG6 (CLUMA_CG013551, isoform A OS=Clunio marinus OX=568069 GN=CLUMA_CG013551 PE=4 SV=1) HSP 1 Score: 312.383 bits (799), Expect = 1.596e-101 Identity = 155/310 (50.00%), Postives = 213/310 (68.71%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG--NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMC--NPELFKMHKNYPF 1005
V LK+G ++P GLGTW S PG+V+ AV++A+++GY+ IDCA+ Y NE+E+G + I+ GKVKREELF+TSKLWN+FH P+ VK LE+TL+NLK YLDL+LIH P+ YK +LFP + + + D V+TWKAMENLVDSG ++SIG+SNFN KQ++ +L+ +RI P MNQVE + Y KKL+E C G+ ITAYSPL G+P+RP ++DPK+LE+++KYN +A QILI Y + RG + IPKSV+ R+ N N +L D D +D+ N+ R C N + H +YPF
Sbjct: 6 VTLKNGQKIPALGLGTWKSPPGQVEQAVKDAIDVGYRHIDCAFVYGNENEVGNAISEKIADGKVKREELFLTSKLWNTFHNPKDVKPALEKTLKNLKTDYLDLYLIHWPMGYKEAGDDLFPKNENGELLFSNDDYVDTWKAMENLVDSGLIKSIGLSNFNSKQIERVLEIARIPPVMNQVECHPYLTQKKLMELCRSKGIHITAYSPL-GSPDRPWAKPGDTELMQDPKLLEISKKYNKSAAQILIKYQLQRGNIVIPKSVTKSRIMSNFDVFNFELNDGDIAAIDAFNMGGRFCPLNFDGLPQHLHYPF 314
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A067QJF4 (Aldo-keto reductase family 1 member B10 OS=Zootermopsis nevadensis OX=136037 GN=L798_02632 PE=4 SV=1) HSP 1 Score: 311.997 bits (798), Expect = 2.212e-101 Identity = 161/319 (50.47%), Postives = 217/319 (68.03%), Query Frame = 1
Query: 52 ICSKIFHLNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKP-GNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
+ SKI L TVK +G E PIFGLGTW SKPGEV AV++A+++GY+ IDCA Y NE E+G ++ I VKRE+LF+TSKLWN+FHR +LV +++TL +L L +LDL+LIH P++Y+ G+LFP+ D K D D V+TWKAME LV G +SIGVSNFN +Q++ IL + IKP NQ+E + Y KKL+EFC V ITAYSPL G+P+RP + L+DPKV E+A++Y T QILI Y + RG +TIPKSV+ R+EEN + + +L++ED +DS + N R+C+ K HK+YPF
Sbjct: 1 MVSKI--LKTPTVKFNNGIEFPIFGLGTWKSKPGEVTQAVKDAIDIGYRHIDCAHVYGNEPEVGAAIKAKIDEKVVKREDLFITSKLWNTFHRTDLVAPAIKKTLSDLGLDFLDLYLIHWPMAYQEGGDLFPEKDG-KTLYSDADYVDTWKAMEKLVQQGLTKSIGVSNFNSEQLERILAVASIKPVTNQIESHPYLNQKKLIEFCKSKDVTITAYSPL-GSPDRPWAKPDDPQLLDDPKVKEVAERYKKTPAQILIRYQVQRGNITIPKSVTKSRIEENAQIFDFELSEEDIAVIDSFDCNGRVCHLTHVKDHKHYPF 315
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A0L0BNI7 (Aldo_ket_red domain-containing protein OS=Lucilia cuprina OX=7375 GN=FF38_05882 PE=4 SV=1) HSP 1 Score: 311.612 bits (797), Expect = 4.454e-101 Identity = 159/317 (50.16%), Postives = 212/317 (66.88%), Query Frame = 1
Query: 73 LNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK--MHKNYPFGED 1014
+N+ T+ L SGH+MP+ GLGTW S GEV AV++A+++GY+ IDCA Y NE E+GE +E I+ G VKRE+LFVTSKLWN+FHRP+LV+ E TL+NLKLSY+D++LIH P+ YK G +LFP + K DVD V+TWK ME LV G V+SIG+SNFN KQ++ +L + I PA NQ+E + Y KKL+EFC + ITAYSPL G+PNRP +EDPK++ +A+KY T QILI Y + RG + IPKSV+ R+ N +L+ ED +DS + N R P L + H +YPF +D
Sbjct: 2 VNVPTITLSSGHKMPVLGLGTWGSPKGEVAQAVKDAIDIGYRHIDCAHVYQNEHEVGEGIEAKINEGVVKREDLFVTSKLWNTFHRPDLVRGACETTLKNLKLSYIDMYLIHWPMGYKEGDDLFPVDEAGKTAYSDVDYVDTWKEMEKLVQDGLVKSIGISNFNKKQIERVLAVATIPPATNQIECHPYLNQKKLMEFCKSKNIAITAYSPL-GSPNRPWAKAGDPVLMEDPKIVAIAEKYQKTPAQILIRYQLQRGNIVIPKSVTKSRIASNFDVFGFELSAEDINTIDSFDCNGRFV-PILSEAGAHPHYPFHDD 316
BLAST of Aldo-keto reductase vs. TrEMBL
Match: A0A226F456 (Aldose reductase OS=Folsomia candida OX=158441 GN=Fcan01_03959 PE=4 SV=1) HSP 1 Score: 311.227 bits (796), Expect = 7.433e-101 Identity = 154/308 (50.00%), Postives = 209/308 (67.86%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK-PGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
TVKL +G E+P FGLGTW SKPGEV+ AVENA+++GY++IDCA AY NE+E+G+ + I G VKRE+LFVT KLWN+FHRP+LV +G+++TL +L L Y+DL+LIH P+ YK G LFP K DVD ++TWK ME V +G+ ++IG SNFN QV+ +L IKPAM QVE + Y KL+E+C + +TAYSPL G+P+RP L DPK+ +A+KY + QI++ + RGL+ IPK+VS RLEENI + KLT ED + ++S + N R C+ + K HK +PF
Sbjct: 29 TVKLNNGAEIPAFGLGTWKSKPGEVRAAVENAIDVGYRMIDCALAYQNENEVGQAIATKIKEGVVKREDLFVTGKLWNTFHRPDLVPIGIKKTLTDLGLDYVDLYLIHWPMGYKEDGELFPKDADGKFMYSDVDYLDTWKEMEAAVRAGQTKAIGFSNFNSDQVERVLQKGTIKPAMLQVECHPYLNQSKLIEWCQGKDIPVTAYSPL-GSPDRPWAKPTDPNLLTDPKLEAIAKKYGKSTAQIILRWNAQRGLIIIPKTVSKARLEENISIFDFKLTHEDMELINSFDCNGRGCHLDWVKDHKYWPF 335
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: akr1b1.2 (aldose reductase-like [Source:NCBI gene;Acc:103035339]) HSP 1 Score: 263.462 bits (672), Expect = 6.827e-86 Identity = 140/310 (45.16%), Postives = 207/310 (66.77%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
+VKL +G +MPI GLGTW S PG+V AV+ A++ GY+ ID A+ Y NE E+GE ++ I G VKREELF+ SKLW +FH+ VK ++TL +L+L YLDL+L+H P+ ++ G L P ++ +D + ++TW+ ME LVD+G V+SIG+SNFN +Q++ IL+ + KPA NQ+E + Y +KLV+FCL G+ +TAYSPL G+P+RP + L+DP + +AQKYN T Q+LI + I R ++ IPKS++ R++EN + + KLTDE+ + + N N R+C + HK+YPF
Sbjct: 4 SVKLSTGADMPILGLGTWKSAPGKVTEAVKAAISAGYRHIDGAFVYQNEKEVGEGIQAMIKEGAVKREELFIVSKLWCTFHKKSAVKGACQKTLSDLQLDYLDLYLVHWPMGFQAGTELLPLDNEGLTINDDTNFLDTWEGMEELVDAGLVKSIGISNFNREQIEAILNKPGLKYKPANNQIECHPYLTQEKLVDFCLSKGISVTAYSPL-GSPDRPWAKPEDPSLLDDPNIKAIAQKYNKTTAQVLIRFHIERNIIVIPKSITPSRIQENFQVFDFKLTDEEMKTILGFNKNFRVCPMQWSVKHKDYPF 312
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: ENSAMXT00000039994.1 (aldose reductase-like [Source:NCBI gene;Acc:103040561]) HSP 1 Score: 258.07 bits (658), Expect = 8.191e-84 Identity = 130/313 (41.53%), Postives = 197/313 (62.94%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
++ L +G MP+ GLGTW S PG+V+ AV+ A+ GY+ ID A+ Y NE E+G + I+ VKRE+LF+ SKLW +FH LV+ E+TL +L L YLDL+L+H P+ ++PG NLFP + + + + ++TW+ ME LVD+G V++IG+SNFN Q++ IL+ + KPA+NQVE + Y +L+ +C G+ +TAYSPL G+P+RP L+DP + +A K+ + Q+LI + I R +V IPKS +A R++EN + + KL+ ++ Q + S N N R C E HK+YP +
Sbjct: 4 SITLNTGARMPLVGLGTWKSTPGQVEEAVKAAIMAGYRHIDGAYVYENEKEVGAAVHAMINQKVVKREDLFIVSKLWCTFHERHLVRGACEKTLSDLNLPYLDLYLVHLPVGFQPGDNLFPFDTEGQAIPDKSNFLDTWEEMEKLVDAGLVKAIGISNFNHFQIEAILNKPGLKYKPAINQVECHPYLTQVRLINYCHSKGIAVTAYSPL-GSPDRPWAKPGDPSLLDDPNIKAIADKHKKSPAQVLIRFHIERNVVVIPKSANAKRIKENFQVFDFKLSPQEMQTILSFNRNWRTCPFEWATKHKDYPLNAE 315
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: ENSAMXT00000046832.1 (aldose reductase-like [Source:NCBI gene;Acc:103040561]) HSP 1 Score: 256.144 bits (653), Expect = 4.732e-83 Identity = 135/312 (43.27%), Postives = 198/312 (63.46%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFP-DADKFKDEIED-VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
++ L +G MP GLGTW S PG+V+ AV+ A+ GY+ ID A+AY NE E+G + I+ VKRE+LF+ SKLW++FH LV+ E TL +L L Y+DL+L+H P+ +KPG +L P DAD + I D + ++TW+ ME LVD+G V++IG+SNFN Q++ +L+ + KP NQ+E + Y KL++FC G+ ITAYSPL G+P+RP L+DPK+ +A K+ T Q+LI + I R + IPKSV+ R++ENI+ + KL+ E+ + S N N R+ + E HK+YP
Sbjct: 4 SIPLNNGARMPTVGLGTWKSTPGQVEEAVKAAILAGYRHIDGAYAYRNEKEVGAAVHAMINQKVVKREDLFIVSKLWSTFHERHLVRGACETTLSDLNLPYIDLYLMHCPMGFKPGEDLLPFDAD--GECIPDNSNFLDTWEEMEKLVDAGLVKAIGISNFNRAQIEALLNKPGLKYKPVTNQIECHPYLTQVKLIDFCHSKGITITAYSPL-GSPDRPWAKPGDPSLLDDPKIKAIADKHKKTTAQVLIRFHIERNVAVIPKSVNPARIKENIQVFDFKLSPEEMSTIMSFNRNWRIAHFEWATKHKDYPL 312
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: ENSAMXT00000052600.1 (aldose reductase-like [Source:NCBI gene;Acc:103040561]) HSP 1 Score: 247.284 bits (630), Expect = 8.976e-80 Identity = 131/302 (43.38%), Postives = 193/302 (63.91%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPG-NLFP-DADKFKDEIED-VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHS--RIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPE 975
++ L +G MP GLGTW S PG+V+ AV+ A+ GY+ ID A+AY NE E+G + I+ VKRE+LF+ SKLW++FH LV+ E TL +L L Y+DL+L+H P+ +KPG +L P DAD + I D + ++TW+ ME LVD+G V++IG+SNFN Q++ +L+ + KP NQ+E + Y KL++FC G+ ITAYSPL G+P+RP L+DPK+ +A K+ T Q+LI + I R + IPKSV+ R++ENI+ + KL+ E+ + S N N R+ + E
Sbjct: 4 SIPLNNGARMPTVGLGTWKSTPGQVEEAVKAAILAGYRHIDGAYAYRNEKEVGAAVHAMINQKVVKREDLFIVSKLWSTFHERHLVRGACETTLSDLNLPYIDLYLMHCPMGFKPGEDLLPFDAD--GECIPDNSNFLDTWEEMEKLVDAGLVKAIGISNFNRAQIEALLNKPGLKYKPVTNQIECHPYLTQVKLIDFCHSKGITITAYSPL-GSPDRPWAKPGDPSLLDDPKIKAIADKHKKTTAQVLIRFHIERNVAVIPKSVNPARIKENIQVFDFKLSPEEMSTIMSFNRNWRIAHFE 302
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Match: ENSAMXT00000036555.1 (aldose reductase-like [Source:NCBI gene;Acc:103035023]) HSP 1 Score: 247.669 bits (631), Expect = 1.014e-79 Identity = 126/310 (40.65%), Postives = 193/310 (62.26%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
T+ L +G +MPI GLGTW S PG+V+ AV+ A+ GY+ ID A Y NE E+G + I G VKRE+LF+ +KLW + H+ LV+ E+ L++L L Y+DL+L+H P+ + P N +FP + + +D + ++TW+ ME LVD G V++IG+SNFN Q++ IL+ + KP NQ+E + Y KL+++C G+ +TAYSPL G+P+RP LEDPK+ +A KYN + Q+LI + + R + IPKS + R++EN++ + KL +E+ + S N N R+ E HK++P
Sbjct: 5 TITLSTGAQMPIIGLGTWKSIPGQVEEAVKTAILAGYRHIDGAVVYENEKEVGTAIRAMIDQGVVKREDLFIVTKLWCTCHQRHLVREACEKALKDLMLDYVDLYLMHMPMGFTPSNEIFPLDAEGQCISDDSNFLDTWEEMEKLVDDGLVKAIGISNFNHFQIEAILNKPGLKHKPVNNQIECHPYLTQVKLIDYCQSKGIAVTAYSPL-GSPDRPWAKPGDPSLLEDPKIKAIAAKYNKSPAQVLIRFHVDRNVAAIPKSANPGRIKENLQVFDFKLNNEEMNTILSFNRNWRILPMEWATKHKDFPL 313
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: akr1a1b (aldo-keto reductase family 1, member A1b (aldehyde reductase) [Source:NCBI gene;Acc:799805]) HSP 1 Score: 209.92 bits (533), Expect = 7.780e-66 Identity = 112/250 (44.80%), Postives = 160/250 (64.00%), Query Frame = 1
Query: 154 EVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNL-FPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILIT-YTIHRGLVTIPKSVSALRLEENIK 894
+VK AV +ALN GY+ IDCA Y NE+E+GE L GK + RE++FVTSKLWN+ H PE V+ ++L++LKL +LDL+LIH P ++ G++ FP + + D ETW+AME LV+ G VR+IG+SNFN +QV I+ + +KPA+ QVE + Y K L+ C GV +TAYSPL G+P+R LE+P + LA KY + Q++I + + RG++ IPKSV+ R+ ENI+
Sbjct: 1 QVKAAVVSALNSGYRHIDCAAVYGNEAEVGEALTECFGAGKPIAREDVFVTSKLWNTKHHPEDVEPSCRKSLQDLKLDFLDLYLIHWPHGFERGDIPFPKNEDGTVRYDYTDYRETWRAMERLVEGGLVRAIGLSNFNSRQVDEIIAIATVKPAILQVESHPYLSQKALLTHCTARGVALTAYSPL-GSPDRAWRQSHEPVVLEEPAIRSLADKYGKSPAQVIIRWWQVQRGVLVIPKSVTPSRIVENIQ 249
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005212.1 (pep scaffold:Pmarinus_7.0:GL480334:1640:10257:1 gene:ENSPMAG00000004669.1 transcript:ENSPMAT00000005212.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 209.149 bits (531), Expect = 1.252e-65 Identity = 127/298 (42.62%), Postives = 186/298 (62.42%), Query Frame = 1
Query: 142 SKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK--PGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRP---LEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM--HKNYPFGED 1014
SKP +V AVE A+ GY+ +D A+ Y NE E+G + I+ G V R++LF+ SKLW FH P VK +TL +L L YLDL+L+H+P+ Y+ L+P D + DVD ++TWKAME+LV G V+S+GVSNFNI Q+ +L + IKP +NQVE++ Y KLV+FC G+ +TAYSP G+P+RP + +K P L+DP V ++A+K++ ++GQIL+ Y I +V IPKSV+ + +N K + L +ED +KL L+ + N K+ HK +P +D
Sbjct: 2 SKPQQVCKAVEAAIEAGYRHVDGAYVYQNEDEVGAGVRACIAKGIVSRDQLFIVSKLWGKFHAPADVKQCFMKTLTDLGLDYLDLYLMHSPMGYQNVGEELYPTMDG-RLLCSDVDYLDTWKAMEDLVKEGLVKSLGVSNFNIPQLNRLLSSASIKPVVNQVELHPYNAQPKLVQFCKSQGIVLTAYSPF-GSPDRPRKLDK--DPGNLLQDPVVADIAKKHSKSSGQILLRYHIENNIVVIPKSVTPANIIQNSKVFDFSLDEEDLKKLAQLDRGWSLANSLFTKLKDHKYFPVNDD 295
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009052.1 (pep scaffold:Pmarinus_7.0:GL484886:6662:24104:-1 gene:ENSPMAG00000008170.1 transcript:ENSPMAT00000009052.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 191.43 bits (485), Expect = 1.474e-59 Identity = 103/226 (45.58%), Postives = 145/226 (64.16%), Query Frame = 1
Query: 307 KLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK--PGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRP---LEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCN 969
+LW +H P VK+G +TL +LKL YLDLFL+H+P+++K +L+P D K DVD V+TWKAME LV G V+SIGVSNFNI Q+Q +L + IKPA+NQVE++ Y P +L+EFC N V +TAYSP G+P+R + EK P L+DP V + K+ T+ Q+L+ Y R +V IPKS++ R+ +N ++ L ED +KL L + R C+
Sbjct: 2 QLWGKYHAPADVKIGFMKTLTDLKLDYLDLFLMHSPMAFKNEGDDLWPIKDG-KILAADVDYVDTWKAMEVLVKEGLVKSIGVSNFNIAQLQRLLSVATIKPAVNQVELHPYLPQPELIEFCQSNNVVLTAYSPF-GSPDREFKNEK-NDPCNLLQDPVVEAIGSKHGKTSAQVLLRYHTQRNIVVIPKSITPSRIVQNAQSFGFTLDGEDTKKLQGLRRDWRACD 224
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: zgc:110782 (zgc:110782 [Source:ZFIN;Acc:ZDB-GENE-050320-51]) HSP 1 Score: 162.155 bits (409), Expect = 1.357e-47 Identity = 98/299 (32.78%), Postives = 155/299 (51.84%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKL-AVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLK-LSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMC-NP 972
+VKL SG MP+ GLGT+ EV A+ AL GY+ +D A Y NE+++ L + + R ++F+TSKL P L+ +L NL YLDL+L+H P + P D E+ E+W+ +E L GK+R+IGVSN+ ++ ++ +L IKP++ QVE + + K+L+E+C +G+ + AYS LG + L + V E+A ++ T Q+L+ + + RG+ IPKS R+ N + KL ED + LD ++ + C NP
Sbjct: 10 SVKLNSGTAMPLLGLGTFKMHGYEVVYGALAAALEHGYRAVDTAAVYSNEADVARALRELLPRHGLTRADVFITSKLAPRDQGPGAAAAALK-SLENLDPGGYLDLYLVHWPGTQG----LPGEDPRNQELRQ----ESWRLLEKLHGEGKLRAIGVSNYTVRHLEELLATCSIKPSVLQVEYHPHLVQKELLEYCQAHGIHMQAYSSLG-----------MGHLLGEVTVQEVASRHGRTPAQVLLRWALERGVGVIPKSTGVERVASNAAVFDFKLAQEDIETLDGMDKQLHYCWNP 288
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Match: akr1b1.1 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-040625-7]) HSP 1 Score: 112.464 bits (280), Expect = 9.676e-30 Identity = 69/210 (32.86%), Postives = 112/210 (53.33%), Query Frame = 1
Query: 424 KPG-NLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIK--PAMNQ--------VEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKL--RRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
+PG +LFP + K + D ++TW+AME LVD+G +R++G+SNFN Q++ IL+ +K P +NQ + N+Y + C K YS P ++ L + L+ P V ++ ++ ++LI + + RG++ IPKSV+ R+ ENI+ + +LT +D + L SLN N R C + HK+YPF D
Sbjct: 2 QPGEDLFPLDENDKVITDGTDFLDTWEAMEALVDAGVIRALGLSNFNRDQIRKILNKPGLKHKPVVNQQYSLHHLHLSANVY------ISKCYKKNHSACLYSKYHTCP---LQWNALGNKSFLKFPSVKSISNSHSLIGSEVLIRFHVQRGVMVIPKSVTKARIHENIQVFDFELTADDMKSLTSLNKNWRACPMQWAVDHKDYPFNTD 202
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: GRE3 (Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000001146]) HSP 1 Score: 196.052 bits (497), Expect = 1.814e-60 Identity = 117/314 (37.26%), Postives = 178/314 (56.69%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK---------PGNLFPDADKFKDEIED--VDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLE------LAQKY-NATAGQILITYTIHRGLVTIPKSVSALRLEENIK-ALNIKLTDEDFQKLDSLNVNIRMCNP 972
V L +G +MP+ GLG W + A+ LGY+L D A Y NE E+GE + + IS G V R+++FV SKLWN+FH P+ VK+ L++TL ++ L YLDL+ IH PI++K PG D+ K I + V +++T++A+E VD G ++SIGVSNF +Q++L RIKP Q+E + Y + LVEFC + +Q+ AYS G P IE + L+ P + E ++Q + +T Q+L+ + RG+ IPKS RL N++ LT+++ + + +LN NIR +P
Sbjct: 5 VTLNNGLKMPLVGLGCWKIDKKVCANQIYEAIKLGYRLFDGACDYGNEKEVGEGIRKAISEGLVSRKDIFVVSKLWNNFHHPDHVKLALKKTLSDMGLDYLDLYYIHFPIAFKYVPFEEKYPPGFYTGADDEKKGHITEAHVPIIDTYRALEECVDEGLIKSIGVSNFQGSLIQDLLRGCRIKPVALQIEHHPYLTQEHLVEFCKLHDIQVVAYSSFG--PQSFIEMD-LQLAKTTPTLFENDVIKKVSQNHPGSTTSQVLLRWATQRGIAVIPKSSKKERLLGNLEIEKKFTLTEQELKDISALNANIRFNDP 315
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: GCY1 (Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication [Source:SGD;Acc:S000005646]) HSP 1 Score: 184.111 bits (466), Expect = 6.689e-56 Identity = 115/327 (35.17%), Postives = 182/327 (55.66%), Query Frame = 1
Query: 67 FHLNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLW-NSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNL-------FP---DADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNIL--DHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNY-PF 1005
H + + L +G ++P GLGTW SK + AV AL GY+ ID A Y NE ++G+ I V REE+FVT+KLW H PE V L+++L+ L L Y+DL+L+H P P + P D + D I + + ++TW+ M+ L +GK +++GVSNF+I ++++L +++ PA NQVE++ P +L+ FC G+ + AYSPLG + P+ L++P +LE+A+K N G ++I++ + RG V +PKSV+ R++ N K L+ EDF+ ++ NI E +H N+ PF
Sbjct: 5 LHDSTKILSLNTGAQIPQIGLGTWQSKENDAYKAVLTALKDGYRHIDTAAIYRNEDQVGQA----IKDSGVPREEIFVTTKLWCTQHHEPE---VALDQSLKRLGLDYVDLYLMHWPARLDPAYIKNEDILSVPTKKDGSRAVD-ITNWNFIKTWELMQELPKTGKTKAVGVSNFSINNLKDLLASQGNKLTPAANQVEIHPLLPQDELINFCKSKGIVVEAYSPLGST-DAPL--------LKEPVILEIAKKNNVQPGHVVISWHVQRGYVVLPKSVNPDRIKTNRKIFT--LSTEDFEAIN----NISKEKGEKRVVHPNWSPF 308
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: YPR1 (NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant [Source:SGD;Acc:S000002776]) HSP 1 Score: 176.022 bits (445), Expect = 8.601e-53 Identity = 103/301 (34.22%), Postives = 172/301 (57.14%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHR-PELVKVGLEETLRNLKLSYLDLFLIHTPISYKP-----GNLFPDADKFKDEIEDVD-----LVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILD--HSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLN 948
T+KL +G +P+ G GTW S +V AL GY+ ID A Y NE E+G R I V REE+F+T+KLW + R PE L ++L+ L L Y+DL+L+H P+ K GN+ +D D+D ++TW+ M+ L +GK +++GVSNF+I ++ +L+ ++++ PA NQ+E++ P +L+ FC + G+ + AYSP G A N P+ L++ ++++A+K+ Q++I+++I RG V + KSV+ R+ N K L ++DF+ + +L+
Sbjct: 11 TLKLNTGASIPVLGFGTWRSVDNNGYHSVIAALKAGYRHIDAAAIYLNEEEVG----RAIKDSGVPREEIFITTKLWGTEQRDPE---AALNKSLKRLGLDYVDLYLMHWPVPLKTDRVTDGNVLC-IPTLEDGTVDIDTKEWNFIKTWELMQELPKTGKTKAVGVSNFSINNIKELLESPNNKVVPATNQIEIHPLLPQDELIAFCKEKGIVVEAYSPFGSA-NAPL--------LKEQAIIDMAKKHGVEPAQLIISWSIQRGYVVLAKSVNPERIVSNFKIFT--LPEDDFKTISNLS 292
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: ARA1 (NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product [Source:SGD;Acc:S000000353]) HSP 1 Score: 174.481 bits (441), Expect = 7.209e-52 Identity = 109/301 (36.21%), Postives = 172/301 (57.14%), Query Frame = 1
Query: 94 LKSGHEMPIFGLGTW--LSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYK----PGNL-----FPDADKFKD-EIEDVDLVETWKAMENLV---DSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLG--GAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSL 945
L +G +P GLGT K E K AV+ A+ GY+ ID AWAY E +GE ++ + G +KRE+LF+T+K+W + V L E+L+ L L Y+DL L H P+ ++ P + P D K D D +ET+K +E + + +VR+IGVSNF+I+ ++ ++ R+KP +NQVE + + P +L +FC + + +TAYSPLG GAPN L+ P V +LA+KYN T +LI+Y I +G + IP+S++ +R+ +I+ + LT ++ Q+L+
Sbjct: 27 LNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPVLW--DEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKGISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN-----------LKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFAS--LTKDELQELNDF 312
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Match: YJR096W_mRNA (Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003857]) HSP 1 Score: 151.369 bits (381), Expect = 9.288e-44 Identity = 90/288 (31.25%), Postives = 158/288 (54.86%), Query Frame = 1
Query: 91 KLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYIS--GGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLK-LSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIK--PAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLD 939
KL +G ++P LGT+ + V + GY+ D A Y NE E+G+ + ++++ G KREE+F T+KLWNS + + K + + L + L Y+DL LIH+P+ + K + +ETW+AM+ VD G V+SIGVSN+ K + +L+ +K P +NQ+E++ + ++L ++C G+ + A++PL G K+ +P +L++ ++ + GQ+LI +++ G + +PK+ + RLE N+ A N +L+DE + LD
Sbjct: 7 KLSNGFKIPSIALGTYDIPRSQTAEIVYEGVKCGYRHFDTAVLYGNEKEVGDGIIKWLNEDPGNHKREEIFYTTKLWNSQNGYKRAKAAIRQCLNEVSGLQYIDLLLIHSPL---------EGSKLR--------LETWRAMQEAVDEGLVKSIGVSNYGKKHIDELLNWPELKHKPVVNQIEISPWIMRQELADYCKSKGLVVEAFAPL-------CHGYKMT----NPDLLKVCKEVDRNPGQVLIRWSLQHGYLPLPKTKTVKRLEGNLAAYNFELSDEQMKFLD 266
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO45157 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTW5]) HSP 1 Score: 236.113 bits (601), Expect = 1.532e-75 Identity = 143/326 (43.87%), Postives = 204/326 (62.58%), Query Frame = 1
Query: 79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDV-----DLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-----------HKNYPF 1005
M TVKL +G EMP+ GLGTW SKPG+V+ AV+ A+ GY+ IDCA+AY NE E+G+ L R + G V+R++LF+TSKLWN+ H P+ V+ ++L++L L YLDL+LIH P+S++ G+ FP KDE +V D +TWKAME LVD G V++IG+SNFN KQV +I +RIKP NQVE + KL++ K+ +Q AYSPLG +RP + DP ++ LA +Y+ T QI I + I RG++ IPKSV+ R++ N + + +L+ ED ++ LN + R C P + K+ H +YPF
Sbjct: 1 MATVKLNNGLEMPVLGLGTWKSKPGQVENAVKFAIKEGYRHIDCAYAYRNEKEVGDAL-RELLGSVVERKDLFITSKLWNTKHNPKDVRSNCVDSLKDLGLDYLDLYLIHWPLSFRDGDEFFP-----KDEQGNVLYAYHDPCDTWKAMEKLVDEGLVKAIGLSNFNSKQVDDICAIARIKPVANQVECHPLLNQAKLIDHHKKHNIQTIAYSPLGSL-DRPWAKPDDPHVMRDPTMVALADRYSRTVAQICIRFQIQRGVLVIPKSVTPERIKSNFQVFDFELSAEDMATIEGLNRDWRACLP-MKKLADGTMVPRDGEHPHYPF 318
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO26953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TAL8]) HSP 1 Score: 235.343 bits (599), Expect = 3.057e-75 Identity = 142/326 (43.56%), Postives = 204/326 (62.58%), Query Frame = 1
Query: 79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDV-----DLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKM-----------HKNYPF 1005
M TVKL +G EMP+ GLGTW SKPG+V+ AV+ A+ GY+ IDCA+AY NE E+G+ L R + G V+R++LF+TSKLWN+ H P+ V+ ++L++L L YLDL+LIH P+S++ G+ FP KDE +V D +TWKAME LVD G V++IG+SNFN KQV +I +RIKP NQVE + KL++ K+ +Q AYSPLG +RP + DP ++ +A +Y+ T QI I + I RG++ IPKSV+ R++ N + + +L+ ED ++ LN + R C P + K+ H +YPF
Sbjct: 1 MATVKLNNGLEMPVLGLGTWKSKPGQVENAVKFAIKEGYRHIDCAYAYRNEKEVGDAL-RELLGSVVERKDLFITSKLWNTKHNPKDVRSNCVDSLKDLGLDYLDLYLIHWPLSFRDGDEFFP-----KDEQGNVLYAYHDPCDTWKAMEKLVDEGLVKAIGLSNFNSKQVDDICAIARIKPVANQVECHPLLNQAKLIDHHKKHNIQTIAYSPLGSL-DRPWAKPDDPHVMRDPTMVAMADRYSRTVAQICIRFQIQRGVLVIPKSVTPERIKSNFQVFDFELSAEDMATIEGLNRDWRACLP-MKKLADGTMVPRDGEHPHYPF 318
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO36411 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIT3]) HSP 1 Score: 224.172 bits (570), Expect = 6.597e-71 Identity = 130/301 (43.19%), Postives = 183/301 (60.80%), Query Frame = 1
Query: 73 LNMLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPD--ADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRP---LEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIR 960
+ + KL +G +P LGTW S EV AV A+ LGY+ IDCA Y NE EIGE L ++ GKVKREELFVTSKLW H P+ V + TL+NL+L YLDL+LIH P+++K G P A+ + + TW+AME LV G ++IGVSNF++K++ +L+ + I PA NQVE++ Y P +KL EFC G+ +TAYSPLG P R + E+L R +E+P + E+A K+N + ++L+ + I RG +PKS S L +N AL + LTD++ + S+ R
Sbjct: 3 MKQIFCKLNTGASIPAMALGTWQSSKEEVGNAVRLAIELGYRHIDCAEIYGNEGEIGEALSEVLTEGKVKREELFVTSKLWCDSHHPDDVLPACQATLKNLQLDYLDLYLIHIPVAFKKGVRLPHSIAEGIIGYTPE-GVQNTWQAMEGLVAKGLCKAIGVSNFSVKRLNKLLETASIVPACNQVELHPYLPQEKLKEFCDSKGILLTAYSPLGN-PGRLVPKERLEREPKVMEEPVIKEIAAKHNCSVARVLLRWGIQRGYPVLPKSTSRDHLHDNFSALGLVLTDDEMAAIKSITTRQR 301
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO45940 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRF6]) HSP 1 Score: 171.014 bits (432), Expect = 6.045e-51 Identity = 102/292 (34.93%), Postives = 152/292 (52.05%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIR 960
T L G+++P FGLG + K AV AL GY++ID A +Y NE +GE L V R E+++ +K++++ H E + +L L + Y+DL+LIH P+ +V +W+AM L G RSIGVSNFNI ++ + HS I P +NQ+EV+ Y ++LV+FC K+ + I AYSPL GEK L DP + L KY T Q+L+ +++ +G + I KSV R+ EN+ N ++ D + LD L N+R
Sbjct: 6 TRTLSDGYKIPRFGLGLYDLDEKHTKQAVLWALENGYRMIDTAASYNNEKRVGEALRE----SAVPRSEVYLVTKVYHTDHGYEKTMKAYDRSLSALGVDYVDLYLIHFPVP-------------------AGVVGSWEAMAELQGKGLTRSIGVSNFNIHHLEALQKHSVIPPVVNQIEVHPYLQMEELVDFCRKHSIAIQAYSPL-------TRGEK----LHDPLLRSLGDKYGKTPAQVLLRWSLQKGYICISKSVQLSRIIENVDVFNFTISMADMEILDGLEENLR 263
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Match: EDO39694 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9F3]) HSP 1 Score: 154.836 bits (390), Expect = 8.520e-45 Identity = 95/289 (32.87%), Postives = 153/289 (52.94%), Query Frame = 1
Query: 94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIR 960
+ G ++P+ GLG + K AV AL GY+LID A Y NE +GE + + R E++V +K++ + H + ++L L L Y+DL+LIH P+ P +V +W+AM +L G +RSIGVSNFNI+ ++ + + + PA+NQ+EV+ + K+L ++C ++ + I A+SPL +GEKL DP + +A+KYN T QIL+ +++ +G IPKS R++EN K + + D + +D L N R
Sbjct: 1 MNDGRKIPLLGLG---AHDIHSKQAVLWALESGYRLIDTASRYHNEQSVGEA----VRCSNIPRCEIYVVTKVYFTEHGYKETMDAFYKSLTRLGLGYVDLYLIHFPV--------PSG-----------VVGSWQAMIDLRSRGLIRSIGVSNFNIQHLEALRQQTGVVPAVNQIEVHPFLQMKELTQYCKRHNITIQAFSPL-------TKGEKLC----DPILSYVAKKYNKTTAQILVRWSLQKGYACIPKSAQLERIKENAKVFDFSIDMADMELIDGLEENYR 252
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: akr1b1.1 (aldose reductase [Source:NCBI gene;Acc:101157264]) HSP 1 Score: 251.521 bits (641), Expect = 3.685e-81 Identity = 137/312 (43.91%), Postives = 204/312 (65.38%), Query Frame = 1
Query: 79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRI--KPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
M TV L +G +MP+ GLGTW G+V AV+ A++ GY+ IDCA+ Y NE EIG ++ I G VKREELF+ SKLW++FH P LVK E+TL +LKL YLDL+L+H P + +PG LFP ++ + ++D + ++TW+AME LVD G V++IGVSNFN +Q++ IL+ + KP NQ+E + Y +K++ +C G+ +TA++PL G+P RP + LE+P + E+A KY ++ QIL+ + R +V + KSV+ R++ENI+ + +L++ED KL S+N N R HK+YPF
Sbjct: 2 MTTVTLSTGAKMPVVGLGTWRGGQGKVGEAVKLAISNGYRHIDCAYVYENEEEIGAAIQAMIDQGVVKREELFIVSKLWSTFHVPSLVKSACEKTLSDLKLDYLDLYLMHFPTAMRPGKELFPKDEENQTILDDTNFLDTWEAMEKLVDDGAVKAIGVSNFNKEQIEAILNKPGLKHKPVTNQIECHPYLNQEKMINYCKSKGIFVTAFAPL-GSPERPWASPEDPTLLEEPIIKEIAAKYKKSSAQILMKFHTQRSVVVLAKSVTPSRIKENIQLFDFELSEEDMAKLRSMNKNWRGFPAAWVAKHKHYPF 312
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: akr1a1a (alcohol dehydrogenase [NADP(+)] A-like [Source:NCBI gene;Acc:101175168]) HSP 1 Score: 247.669 bits (631), Expect = 1.305e-79 Identity = 132/317 (41.64%), Postives = 188/317 (59.31%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGN-LFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFK---------MHKNYPF 1005
V L SG MP+ GLGTW S G+VK AV AL GY+ IDCA Y NE EIGE L + GK ++REELFVTSKLWN+ H PE V+ +L +L LSYLDL+L+H P++++ G L P + + +TWKAMENLVD G V++IG+SNFN +Q++ I+ ++ KP +NQVE + Y L+ C + +TAYSPLG +RP LEDPK+ +AQ+Y + Q+++ + I RG+ IPKSV+ R+++N+ + L+ ED + ++S + R P K H ++PF
Sbjct: 5 VTLSSGQRMPMIGLGTWKSSAGQVKQAVVAALECGYRHIDCAAVYGNEQEIGEALALCVGPGKTLRREELFVTSKLWNTKHDPEDVEDACRTSLAHLGLSYLDLYLMHWPMAFQKGKELMPRRNDGTICYSNTHYRDTWKAMENLVDKGLVKAIGLSNFNARQMEEIIRVAKHKPVVNQVECHPYLSQADLLSHCQSLAICVTAYSPLGSG-DRPWASPDEPSLLEDPKLGVIAQRYQKSPAQVILRWHIQRGVACIPKSVTLSRIQQNLNVFDFNLSQEDMKLINSFSCKRRFIVPTAVKDGKTVWRDAEHPHFPF 320
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: akr1a1b (aldo-keto reductase family 1 member A1 [Source:NCBI gene;Acc:101172969]) HSP 1 Score: 243.817 bits (621), Expect = 5.087e-78 Identity = 130/295 (44.07%), Postives = 191/295 (64.75%), Query Frame = 1
Query: 94 LKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGK-VKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNL-FPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNP 972
L +G +MP+ GLGTW S+PG+VK AV AL GY+ IDCA Y NE+EIGE L+ + K ++RE++F+TSKLWN+ H PE V+ L +TL++L+L YLDL+LIH P ++ G++ FP + + +D TW AME LV+ G VRSIG+SNFN +QV +IL + IKP + QVE + Y +L+ C G+ +TAYSPL G+P+R + + L++P V+ LA+KY + QIL+ + RG+V IPKSV+ R++ENI+ + L E+ + + +L+ R P
Sbjct: 7 LNTGRKMPLVGLGTWKSEPGKVKQAVLWALEAGYRHIDCAAIYGNEAEIGEALKEMLGPSKPLRREDIFITSKLWNTRHHPEDVEPALLKTLKDLQLEYLDLYLIHWPHGFQRGDVPFPKKEDGSLIYDHIDYKLTWAAMEKLVEKGLVRSIGLSNFNSRQVDDILSVASIKPTVLQVESHPYLAQVELLAHCRNRGLVMTAYSPL-GSPDRAWKRPEEPVLLQEPVVISLAEKYQKSPAQILLRWQTQRGVVVIPKSVTESRIKENIQVFDFSLEAEEVKSITALDRGCRYIVP 300
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: AKR1D1 (3-oxo-5-beta-steroid 4-dehydrogenase [Source:NCBI gene;Acc:101170970]) HSP 1 Score: 241.891 bits (616), Expect = 2.884e-77 Identity = 125/317 (39.43%), Postives = 194/317 (61.20%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTW---LSKP-GEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLF-PDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIK--PAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
++ L G+ +P+ GLGT+ ++ P G AV+ A+ +GY+ D A Y NE E+G+ + I+ G VKRE++F KLWN+FH PELV+ LE+TL+ L+L Y+DL+++ P ++KPG+ F P + K DL TW+A+E D+G V+S+GVSNFN +Q++ IL+ +K P NQVE + YF KL+EFC +N + I YSPLG + + K LED + +A+KY+ T Q+ + + + RG+V IPKS ++ R++EN + L+DE+ + ++ LN NIR ++ H YPF E+
Sbjct: 9 SIPLSDGNRIPLIGLGTYGDPITTPKGATSEAVKLAIEVGYRHFDGALVYFNEHEVGQAIREKIADGTVKREDIFYCGKLWNTFHPPELVRTALEKTLKTLQLDYVDLYIVELPTAFKPGDSFYPRDENGKYLYHTTDLCATWEALEACKDAGLVKSLGVSNFNKRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLEFCRQNNIVIVGYSPLGTSRDASWVNLKCPPLLEDEVLKSVAKKYSKTTAQVCLRFNVQRGVVVIPKSFTSARIKENFDIFDFCLSDEEMKAIEGLNKNIRFVELLMWADHPEYPFHEE 325
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Match: zgc:56622 (aldose reductase-related protein 2 [Source:NCBI gene;Acc:101171575]) HSP 1 Score: 241.121 bits (614), Expect = 6.050e-77 Identity = 127/315 (40.32%), Postives = 190/315 (60.32%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWLSK---PGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKP--GNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIE----GEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPF 1005
++L G MPI GLGTW S P V+ AVE A+ GY+ ID A++Y NE ++G L + G ++RE++F+ SKL + H PE + + L ++L++L+L +LDL+L+H P+ K LFP D K D+D V+ W+ ME L SGKVRSIGVSNF+I Q++ +L R+ PA+NQVE++ Y ++EFC + +TA+SP G+P RP + G + LEDP + ++A+++ +A Q+L+ Y I +G+ IPKS + +N K + +L++ED L SLN R C E K H YPF
Sbjct: 20 IELNDGSRMPILGLGTWKSSHLPPNSVQGAVEAAIAAGYRHIDTAYSYGNEVDVGRALRSKMRQGIIRREDMFIVSKLCETHHAPEDIPLCLNKSLKDLQLDFLDLYLVHFPVGLKKVGDELFPMKDG-KVLTSDIDYVDVWRGMEALQASGKVRSIGVSNFSILQLERLLALCRVPPAVNQVELHPYLVQADMIEFCKLKNIALTAFSPF-GSPARPPDEFKCGTDPHKLLEDPVIAQIAERHRRSAAQVLLRYHIQQGVSVIPKSDKPHHIIQNTKIFDFQLSEEDMTTLKSLNRGWRGCRIEELKSHPYYPF 332
BLAST of Aldo-keto reductase vs. Planmine SMEST
Match: SMESG000062723.1 (SMESG000062723.1) HSP 1 Score: 639.417 bits (1648), Expect = 0.000e+0 Identity = 312/312 (100.00%), Postives = 312/312 (100.00%), Query Frame = 1
Query: 79 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED
Sbjct: 1 MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 312
BLAST of Aldo-keto reductase vs. Planmine SMEST
Match: SMESG000081151.1 (SMESG000081151.1) HSP 1 Score: 479.174 bits (1232), Expect = 6.730e-171 Identity = 234/310 (75.48%), Postives = 270/310 (87.10%), Query Frame = 1
Query: 85 TVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVETWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMCNPELFKMHKNYPFGED 1014
++KL SG+++P FGLGTWLSKPGE+K ++E+ALNLGY IDCAW YCNE EIG VLE YIS GK+KREELFVTSKLWN+FHRPELVKVG EETL NL+L YLDL+LIH PIS KPGN+ P ADKFKDE++DVDL++TWK ME LVDSGK+RSIG+SNFNI+Q+QNILDH +IKPAM Q+EVNIYFPNKKLVEFCLKN +Q+TAY PLGGAP+RP E +RPL DP VLELA+KYNAT G ILI+Y IHRGL+ IPKSVS+ RLEENIKALNIKL+DEDFQ LD+LNVNIR C P +FK+HKNYPF ED
Sbjct: 4 SIKLNSGYDVPNFGLGTWLSKPGEIKASLESALNLGYNHIDCAWVYCNEKEIGGVLEDYISNGKIKREELFVTSKLWNAFHRPELVKVGFEETLSNLRLDYLDLYLIHWPISIKPGNILPSADKFKDELDDVDLIKTWKEMEKLVDSGKIRSIGLSNFNIRQIQNILDHCKIKPAMLQIEVNIYFPNKKLVEFCLKNDIQVTAYCPLGGAPDRPGATEGEKRPLSDPTVLELAKKYNATPGVILISYIIHRGLICIPKSVSSARLEENIKALNIKLSDEDFQLLDNLNVNIRSCCPLMFKLHKNYPFDED 313
BLAST of Aldo-keto reductase vs. Planmine SMEST
Match: SMESG000015779.1 (SMESG000015779.1) HSP 1 Score: 147.902 bits (372), Expect = 1.243e-41 Identity = 94/298 (31.54%), Postives = 162/298 (54.36%), Query Frame = 1
Query: 88 VKLKSGHEMPIFGLGTWL-SKPGEVKLAVENALNLGYKLIDCAWAYCNESEIGEVLERYISGGKVKREELFVTSKLWNSFHRPELVKVGLEETLRNLKLSYLDLFLIHTPISYKPGNLFPDADKFKDEIEDVDLVE----TWKAMENLVDSGKVRSIGVSNFNIKQVQNILDHSRIKPAMNQVEVNIYFPNKKLVEFCLKNGVQITAYSPLGGAPNRPIEGEKLRRPLEDPKVLELAQKYNATAGQILITYTIHRGLVTIPKSVSALRLEENIKALNIKLTDEDFQKLDSLNVNIRMC 966
+ L ++P GT+L ++ ++ ++ AL GY+ ID A Y NE+ +G++L+ + +KRE++F+T+KL S E K ++ +L L+L YLDL+LIH P + K ++ ++ +E +WKAME G +RSIGVSN+ IK ++ + +++ I P++NQVE + + +LV+FC N + AYS LG N + +E V +LAQ + QIL+ + I++G +PKS + +E+NI+ + +LT + ++L +N R C
Sbjct: 2 ITLNDKFKIPSVLFGTYLINEENLLEECLDKALVSGYRGIDTAAVYRNEAFLGKILKSKLLKYNLKREDIFITTKLAPSEQGYEKAKAAIKNSLDKLQLEYLDLYLIHWPGTSKL------------DLTSLEHLENRKGSWKAMEEAKKIGLIRSIGVSNYMIKHLEEMKNYANILPSVNQVECHPFLNQHELVKFCQANNIHFQAYSSLGTTANH-------LKLIEHSTVQKLAQLLQRSPAQILLKWAINQGFSVLPKSTNLEHIEKNIQLFDWQLTVQQMKELFEMNKEERFC 280 The following BLAST results are available for this feature:
BLAST of Aldo-keto reductase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Aldo-keto reductase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Aldo-keto reductase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Aldo-keto reductase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Aldo-keto reductase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30008929 ID=SMED30008929|Name=Aldo-keto reductase|organism=Schmidtea mediterranea sexual|type=transcript|length=1115bpback to top protein sequence of SMED30008929-orf-1 >SMED30008929-orf-1 ID=SMED30008929-orf-1|Name=SMED30008929-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=313bp MLTVKLKSGHEMPIFGLGTWLSKPGEVKLAVENALNLGYKLIDCAWAYCNback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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