26S proteasome non-ATPase regulatory subunit 12

Overview


Name	26S proteasome non-ATPase regulatory subunit 12
Smed ID	SMED30008839
Length (bp)	1355

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of 26S proteasome non-ATPase regulatory subunit 12 (SMED30008839) t-SNE clustered cells

Violin plots show distribution of expression levels for 26S proteasome non-ATPase regulatory subunit 12 (SMED30008839) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of 26S proteasome non-ATPase regulatory subunit 12 (SMED30008839) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30008839

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30008839	SMESG000057467.1	SmedASXL_006710	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30008839	SMESG000057467.1	dd_Smed_v4_2546_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30008839	SMESG000057467.1	dd_Smed_v4_2546_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30008839	SMESG000057467.1	dd_Smed_v4_2546_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30008839	SMESG000057467.1	dd_Smed_v4_2546_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30008839	SMESG000057467.1	dd_Smed_v4_2546_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30008839	SMESG000057467.1	SMED30008839	smed_20140614	PMID:22696458 Labbé et al., 2012

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Homology

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Human
Match: PSMD12 (proteasome 26S subunit, non-ATPase 12 [Source:HGNC Symbol;Acc:HGNC:9557])

HSP 1 Score: 429.869 bits (1104), Expect = 1.438e-147
Identity = 232/449 (51.67%), Postives = 317/449 (70.60%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            ++ +I+KMEVDYSA V+  + E   +     + E ++ L   EK TR ASD +ST ++L   +++C +  EW  LNE ++L +K+RSQLKQAV KMVQ+ C Y+++      KL  I+++R VTEGKIYVE+ERAR++K LA IKE +GDV+ AA+ILQ+LQVETYGSM+KKE++EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ   E     LK+V+++++LAPFD+EQ+DL+  H+ S +K LE++   K+++ LF T E+M W    E Y  EL++        D     E+G  RW  L+NR+VEHNIRIMA+YYT+I + +MA +LD+     E FLS+LVVNKTI AKVDRL GI +F +PKD   ++NDWS  +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 ADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLV--HRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 455

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Human
Match: PSMD12 (proteasome 26S subunit, non-ATPase 12 [Source:HGNC Symbol;Acc:HGNC:9557])

HSP 1 Score: 419.853 bits (1078), Expect = 6.382e-144
Identity = 229/446 (51.35%), Postives = 311/446 (69.73%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISEIKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            ++ +I+KMEVDYSA V+  + E                C KL + ASD +ST ++L   +++C +  EW  LNE ++L +K+RSQLKQAV KMVQ+ C Y+++      KL  I+++R VTEGKIYVE+ERAR++K LA IKE +GDV+ AA+ILQ+LQVETYGSM+KKE++EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ   E     LK+V+++++LAPFD+EQ+DL+  H+ S +K LE++   K+++ LF T E+M W    E Y  EL++        D     E+G  RW  L+NR+VEHNIRIMA+YYT+I + +MA +LD+     E FLS+LVVNKTI AKVDRL GI +F +PKD   ++NDWS  +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 ADGRIVKMEVDYSATVDQRLPE----------------CAKLAK-ASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLV--HRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 435

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Celegans
Match: rpn-5 (Proteasome Regulatory Particle, Non-ATPase-like [Source:UniProtKB/TrEMBL;Acc:Q19324])

HSP 1 Score: 266.159 bits (679), Expect = 9.932e-84
Identity = 169/451 (37.47%), Postives = 273/451 (60.53%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISEIK--TNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXF--IDEN-FEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRA-FCEKYEQELKRDP-------IF-MNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIE-AKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVH 1342
             + ++ KME DYS +V+  + + +    ++   A++ L   EKLTRL +D  S  ++++   ++C +  +W  L E ++  +KKR  +K A+ KMV+ A   IDK P+E+ K+  I ++R VT GKIYVEVERAR++  +    E  G ++ AA +L +LQVETYGSM+ +EK++++LEQMR  L + D +R  IISKKI+ K F   DE+  + LKLK+Y  MI + L + NYL++ +H+ EIY++K I+        +L++ +V+ LLAP  +EQ DLL R   + +++LE +   K I+ LF  +E++ ++     KYE+ L+R         IF  + +G  RW  L  R+ EHN+R++A+YYTQI   ++A +LD     +E F+ +L+V   I  AK+ R   I +    K   E ++ W+ N+++L   + K +HLI KE+MVH
Sbjct:   32 GDGRLFKMEQDYSKQVDEALLKARDIAQKDAVAAVESLNNIEKLTRLGADMKSNTRVVQYMTKLCFEGQKWDLLMETIMTLSKKRLLIKMAIAKMVRDAVAMIDKMPTEDLKMKLIETLRTVTAGKIYVEVERARLTSMVVKKLEREGKLDEAATMLLELQVETYGSMEMREKVQYLLEQMRYSLVRNDFVRATIISKKINIKFFNKSDEDEVQNLKLKYYDSMIRIGLHDGNYLDVCRHHREIYETKKIKADSAKATSHLRSAIVYCLLAPHTNEQWDLLNR--IAIQRELETVPDYKIILDLFINQELISFKGTIVAKYEKLLRRGTTSSPDTGIFDKSTEGEKRWSDLHLRVGEHNMRMIAKYYTQITFERLAELLDFPVDEMESFVCNLIVTGQITGAKLHRPSRIVNLRLKKANVEQLDVWASNVHKLTDTLNKVSHLILKEQMVH 480

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Query:   35 SENKILKMEVDYSAEVENWISEIK--TNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXF--IDEN-FEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRA-FCEKYEQELKRDP-------IF-MNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIE-AKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVH 1342
             + ++ KME DYS +V+  + + +    ++   A++ L   EKLTRL +D  S  ++++   ++C +  +W  L E ++  +KKR  +K A+ KMV+ A   IDK P+E+ K+  I ++R VT GKIYVEVERAR++  +    E  G ++ AA +L +LQVETYGSM+ +EK++++LEQMR  L + D +R  IISKKI+ K F   DE+  + LKLK+Y  MI + L + NYL++ +H+ EIY++K I+        +L++ +V+ LLAP  +EQ DLL R   + +++LE +   K I+ LF  +E++ ++     KYE+ L+R         IF  + +G  RW  L  R+ EHN+R++A+YYTQI   ++A +LD     +E F+ +L+V   I  AK+ R   I +    K   E ++ W+ N+++L   + K +HLI KE+MVH
Sbjct:   32 GDGRLFKMEQDYSKQVDEALLKARDIAQKDAVAAVESLNNIEKLTRLGADMKSNTRVVQYMTKLCFEGQKWDLLMETIMTLSKKRLLIKMAIAKMVRDAVAMIDKMPTEDLKMKLIETLRTVTAGKIYVEVERARLTSMVVKKLEREGKLDEAATMLLELQVETYGSMEMREKVQYLLEQMRYSLVRNDFVRATIISKKINIKFFNKSDEDEVQNLKLKYYDSMIRIGLHDGNYLDVCRHHREIYETKKIKADSAKATSHLRSAIVYCLLAPHTNEQWDLLNR--IAIQRELETVPDYKIILDLFINQELISFKGTIVAKYEKLLRRGTTSSPDTGIFDKSTEGEKRWSDLHLRVGEHNMRMIAKYYTQITFERLAELLDFPVDEMESFVCNLIVTGQITGAKLHRPSRIVNLRLKKANVEQLDVWASNVHKLTDTLNKVSHLILKEQMVH 480

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Fly
Match: Rpn5 (gene:FBgn0028690 transcript:FBtr0078629)

HSP 1 Score: 334.724 bits (857), Expect = 3.743e-110
Identity = 200/491 (40.73%), Postives = 295/491 (60.08%), Query Frame = 2

Query:   41 NKILKMEVDYSAEVENWIS-----EIKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSK---------------------------------------------SIQLSEESR---LLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPIFMN--EQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
             +I KMEVDY       I        K  +  +EA++ +   EK TRL +D +S  ++L    +IC D + W  LNE + L  ++RSQLKQAV KM+Q+   Y+DK P +E+KL  I+++R VTEGKIYVE+ERAR++K LADIKE  GDV GAA ++++LQVETYGSMDK+EK+E ILEQMRLCL K+D + TQII+KKIS K F D     LKLKFY LMI L+  + ++LN S+HY  I +                                                I+L+EE +      L   +++ +LAPFD+EQ+D++    K+  K LE++   KEI+ LF +KE++ +  F   +   L  + +F +  + G     +L++R++EHNIRI+A YY+++ L +M+ +L++     E++LS L    TI  K+DR  GI +FT+ K A++I+N+W+ ++NQL+SL+ KT HLINKE+ V+ V
Sbjct:    9 GRITKMEVDYEPACNEKIPLAKELAKKNPDAFHEAIEMMLQLEKQTRLGADMVSCSRVLVAICQICFDASNWNALNEYVSLLVRRRSQLKQAVVKMIQECVTYVDKTPDKETKLKLIDTLRSVTEGKIYVEIERARLTKILADIKEADGDVAGAATVMEELQVETYGSMDKREKVELILEQMRLCLLKEDYVSTQIIAKKISIKFFDDPAQHDLKLKFYYLMIQLN-RDTSFLNTSRHYQAIAEPPRKKTGLTPVDSAASTDEQKKKDDDKKKKEEDDKDKKPEVATEAEVEIELTEEQKKELTEKLVCAVLYCVLAPFDNEQSDMMAHLSKN--KKLEEVPAYKEILRLFMSKELINFDTFNADFGLVLAENEMFKDSTKHGKKCITELKDRLIEHNIRIIAMYYSRLHLARMSELLNLPTSRCEEYLSKLANTDTIRVKIDRPAGIIYFTQKKSASDILNNWATDVNQLMSLVNKTCHLINKEECVYSV 496

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Zebrafish
Match: psmd12 (proteasome 26S subunit, non-ATPase 12 [Source:ZFIN;Acc:ZDB-GENE-030131-617])

HSP 1 Score: 421.009 bits (1081), Expect = 2.637e-144
Identity = 228/449 (50.78%), Postives = 316/449 (70.38%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            S+ +I+KMEVDYSA V+  + E   +  +  + EA++ L   EK TR ASD +ST ++L   +++C +  +W  LNE ++L +K+RSQLKQAV KMVQ+  +Y+D       KL  I+++R VT GKIYVE+ERAR++K LA IKE SGDV+ AAAILQ+LQVETYGSM+KKEK EFILEQMRLC+A KD IRTQIISKKI++K F +E  E LKLK+Y LMI +DL E +YL+I KHY  IY +  I          LK+V+++++LAP+D+EQ+DL+  H+ S +K LE++   ++++  F T E+M W +  E Y +EL+         D     E+G  RW  L+NR+VEHNIRIMA+YYT I + +MA++LD+     E+FLS+LVVNKTI AKVDRL GI +F +PKD  +++NDWS  +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 SDGRIVKMEVDYSATVDERLPECEKMAKDGRLQEAVESLLSLEKQTRTASDMVSTSRILVAIVQLCYEAKDWDALNENIMLLSKRRSQLKQAVAKMVQECYKYVDAMTDLSIKLRLIDTLRTVTAGKIYVEIERARLTKTLAHIKEQSGDVKEAAAILQELQVETYGSMEKKEKAEFILEQMRLCIAVKDYIRTQIISKKINTKFFQEEGTEELKLKYYNLMIQVDLHEGSYLSICKHYRAIYDTPCILEDSSKWQQALKSVVLYVILAPYDNEQSDLV--HRISTDKKLEEIPKYRDLLKQFTTMELMRWSSVVEDYGKELREGSMGTPDTDVFTCTEEGEKRWKDLKNRVVEHNIRIMAKYYTSITMGRMAALLDLSVDESEEFLSNLVVNKTIYAKVDRLAGIINFQRPKDPNDLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 455

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Mouse
Match: Psmd12 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [Source:MGI Symbol;Acc:MGI:1914247])

HSP 1 Score: 426.017 bits (1094), Expect = 2.642e-146
Identity = 229/449 (51.00%), Postives = 317/449 (70.60%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            ++ +I+KMEVDYSA V+  + E   +     + E ++ L   EK TR ASD +ST ++L   +++C +  EW  LNE ++L +K+RSQLKQAV KMVQ+ C Y+++      KL  I+++R VTEGKIYVE+ERAR++K LA IKE +GDV+ AA+ILQ+LQVETYGSM+KKE++EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ   +     LK+V+++++LAPFD+EQ+DL+  H+ S +K LE++   K+++ LF T E+M W    E Y  EL++        D     E+G  RW  L++R+VEHNIRIMA+YYT+I + +MA +LD+     E FLS+LVVNKTI AKVDRL G+ +F +PKD   ++NDWS  +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 ADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTENLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESDKWQQALKSVVLYVILAPFDNEQSDLV--HRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKGSSETPATDVFSSTEEGEKRWKDLKSRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 455

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Mouse
Match: Psmd12 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [Source:MGI Symbol;Acc:MGI:1914247])

HSP 1 Score: 417.927 bits (1073), Expect = 2.368e-143
Identity = 227/446 (50.90%), Postives = 312/446 (69.96%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISEIKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            ++ +I+KMEVDYSA V+  + E                CEKL + ASD +ST ++L   +++C +  EW  LNE ++L +K+RSQLKQAV KMVQ+ C Y+++      KL  I+++R VTEGKIYVE+ERAR++K LA IKE +GDV+ AA+ILQ+LQVETYGSM+KKE++EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ   +     LK+V+++++LAPFD+EQ+DL+  H+ S +K LE++   K+++ LF T E+M W    E Y  EL++        D     E+G  RW  L++R+VEHNIRIMA+YYT+I + +MA +LD+     E FLS+LVVNKTI AKVDRL G+ +F +PKD   ++NDWS  +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 ADGRIVKMEVDYSATVDQRLPE----------------CEKLAK-ASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTENLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESDKWQQALKSVVLYVILAPFDNEQSDLV--HRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKGSSETPATDVFSSTEEGEKRWKDLKSRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 435

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Mouse
Match: Psmd12 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [Source:MGI Symbol;Acc:MGI:1914247])

HSP 1 Score: 345.51 bits (885), Expect = 2.516e-115
Identity = 190/379 (50.13%), Postives = 265/379 (69.92%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIG 1138
            ++ +I+KMEVDYSA V+  + E   +     + E ++ L   EK TR ASD +ST ++L   +++C +  EW  LNE ++L +K+RSQLKQAV KMVQ+ C Y+++      KL  I+++R VTEGKIYVE+ERAR++K LA IKE +GDV+ AA+ILQ+LQVETYGSM+KKE++EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ   +     LK+V+++++LAPFD+EQ+DL+  H+ S +K LE++   K+++ LF T E+M W    E Y  EL++        D     E+G  RW  L++R+VEHNIRIMA+YYT+I + +MA +LD+ 
Sbjct:    9 ADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTENLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESDKWQQALKSVVLYVILAPFDNEQSDLV--HRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKGSSETPATDVFSSTEEGEKRWKDLKSRVVEHNIRIMAKYYTRITMKRMAQLLDLS 385

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. UniProt/SwissProt
Match: sp|Q2KJ25|PSD12_BOVIN (26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus OX=9913 GN=PSMD12 PE=2 SV=3)

HSP 1 Score: 429.869 bits (1104), Expect = 6.611e-147
Identity = 232/449 (51.67%), Postives = 317/449 (70.60%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            ++ +I+KMEVDYSA V+  + E   +     + E ++ L   EK TR ASD +ST ++L   +++C +  EW  LNE ++L +K+RSQLKQAV KMVQ+ C Y+++      KL  I+++R VTEGKIYVE+ERAR++K LA IKE +GDV+ AA+ILQ+LQVETYGSM+KKE++EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ   E     LK+V+++++LAPFD+EQ+DL+  H+ S +K LE++   K+++ LF T E+M W    E Y  EL++        D     E+G  RW  L+NR+VEHNIRIMA+YYT+I + +MA +LD+     E FLS+LVVNKTI AKVDRL GI +F +PKD   ++NDWS  +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 ADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAIVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLV--HRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGYTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 455

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. UniProt/SwissProt
Match: sp|O00232|PSD12_HUMAN (26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3)

HSP 1 Score: 429.869 bits (1104), Expect = 6.905e-147
Identity = 232/449 (51.67%), Postives = 317/449 (70.60%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            ++ +I+KMEVDYSA V+  + E   +     + E ++ L   EK TR ASD +ST ++L   +++C +  EW  LNE ++L +K+RSQLKQAV KMVQ+ C Y+++      KL  I+++R VTEGKIYVE+ERAR++K LA IKE +GDV+ AA+ILQ+LQVETYGSM+KKE++EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ   E     LK+V+++++LAPFD+EQ+DL+  H+ S +K LE++   K+++ LF T E+M W    E Y  EL++        D     E+G  RW  L+NR+VEHNIRIMA+YYT+I + +MA +LD+     E FLS+LVVNKTI AKVDRL GI +F +PKD   ++NDWS  +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 ADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLV--HRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 455

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. UniProt/SwissProt
Match: sp|Q5RBI3|PSD12_PONAB (26S proteasome non-ATPase regulatory subunit 12 OS=Pongo abelii OX=9601 GN=PSMD12 PE=2 SV=3)

HSP 1 Score: 428.328 bits (1100), Expect = 2.781e-146
Identity = 231/449 (51.45%), Postives = 316/449 (70.38%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            ++ +I+KMEVDYS  V+  + E   +     + E ++ L   EK TR ASD +ST ++L   +++C +  EW  LNE ++L +K+RSQLKQAV KMVQ+ C Y+++      KL  I+++R VTEGKIYVE+ERAR++K LA IKE +GDV+ AA+ILQ+LQVETYGSM+KKE++EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ   E     LK+V+++++LAPFD+EQ+DL+  H+ S +K LE++   K+++ LF T E+M W    E Y  EL++        D     E+G  RW  L+NR+VEHNIRIMA+YYT+I + +MA +LD+     E FLS+LVVNKTI AKVDRL GI +F +PKD   ++NDWS  +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 ADGRIVKMEVDYSPTVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLV--HRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 455

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. UniProt/SwissProt
Match: sp|Q9D8W5|PSD12_MOUSE (26S proteasome non-ATPase regulatory subunit 12 OS=Mus musculus OX=10090 GN=Psmd12 PE=1 SV=4)

HSP 1 Score: 426.017 bits (1094), Expect = 1.848e-145
Identity = 229/449 (51.00%), Postives = 317/449 (70.60%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            ++ +I+KMEVDYSA V+  + E   +     + E ++ L   EK TR ASD +ST ++L   +++C +  EW  LNE ++L +K+RSQLKQAV KMVQ+ C Y+++      KL  I+++R VTEGKIYVE+ERAR++K LA IKE +GDV+ AA+ILQ+LQVETYGSM+KKE++EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ   +     LK+V+++++LAPFD+EQ+DL+  H+ S +K LE++   K+++ LF T E+M W    E Y  EL++        D     E+G  RW  L++R+VEHNIRIMA+YYT+I + +MA +LD+     E FLS+LVVNKTI AKVDRL G+ +F +PKD   ++NDWS  +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 ADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTENLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESDKWQQALKSVVLYVILAPFDNEQSDLV--HRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKGSSETPATDVFSSTEEGEKRWKDLKSRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 455

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. UniProt/SwissProt
Match: sp|Q12250|RPN5_YEAST (26S proteasome regulatory subunit RPN5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPN5 PE=1 SV=3)

HSP 1 Score: 302.753 bits (774), Expect = 2.367e-97
Identity = 178/442 (40.27%), Postives = 286/442 (64.71%), Query Frame = 2

Query:   32 MSENKILKMEVDYSAEVENWISEIKT--NENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEE--SKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPI-FMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVH 1342
            MS +  +K + DYS  ++    +I +    + N ALD+L V EK TR ASD  S+ ++L   +++ A RN+W  LNE + L +KK  QLK ++  M+QK  EY+  + S +  +++S I +IR VTE KI+VEVERARV+K L +IK+  G ++ AA IL +LQVETYGSM+  EKI+FILEQM L + K D  +  ++S+KI  K+F +  +E LKL++Y L++ + L +  YL ++++  EIYQ+ +I+  E      L +++ FL+L+P+ + QNDL+  HK   + +L+KL + + ++ LF T E+M W    + YE  L  D + F  E     W+ LQ R++EHN+R+++EYY++I L ++  +LD+ E   E ++SDLV    I AKV+R   I +F KPK++++++N+WS+N+++LL  I+   HLI KE+++H
Sbjct:    1 MSRDAPIKADKDYSQILKEEFPKIDSLAQNDCNSALDQLLVLEKKTRQASDLASSKEVLAKIVDLLASRNKWDDLNEQLTLLSKKHGQLKLSIQYMIQKVMEYLKSSKSLDLNTRISVIETIRVVTENKIFVEVERARVTKDLVEIKKEEGKIDEAADILCELQVETYGSMEMSEKIQFILEQMELSILKGDYSQATVLSRKILKKTFKNPKYESLKLEYYNLLVKISLHKREYLEVAQYLQEIYQTDAIKSDEAKWKPVLSHIVYFLVLSPYGNLQNDLI--HKIQNDNNLKKLESQESLVKLFTTNELMRWPIVQKTYEPVLNEDDLAFGGEANKHHWEDLQKRVIEHNLRVISEYYSRITLLRLNELLDLTESQTETYISDLVNQGIIYAKVNRPAKIVNFEKPKNSSQLLNEWSHNVDELLEHIETIGHLITKEEIMH 440

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. TrEMBL
Match: C1LIY4 (26S proteasome non-ATPase regulatory subunit 12 isoform 2 OS=Schistosoma japonicum OX=6182 GN=Psmd12 PE=2 SV=1)

HSP 1 Score: 462.996 bits (1190), Expect = 1.001e-157
Identity = 242/440 (55.00%), Postives = 329/440 (74.77%), Query Frame = 2

Query:   53 KMEVDYSAEVENWISEIK---TNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPIFMNEQG-----AARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            KMEVDYS  V+N ++ IK   T  N + A+++    EK TR ASDAISTG+LLE  +EI A+ ++W +LNE ++L TKK  Q+KQAV+KMVQKA EY++K PSE  KL  I ++R+VTEGKIYVE ERAR++K LA IKE  GD+EGAAA+LQDLQVET+GSM+KKEK+EF+LEQMRLCLAKKD IRTQIIS KIS+K F D   E LKLKFY LMIDL+  ++ YLNISK+Y+EIY SKSIQ  E+ RLL L++V+++LLL+P+D+EQ+DL+ R K    KD+EK+ +  +++  F T+E++ W  FC++YE  L+ +    +++G       RW  L  R++EHNIR+++ YYT+IRL +++ +LD+     E++LS LVVNKT+ AK+DRL G+ HF   K  TE++NDWSYN   L++LI +T HLINKE+M++ V
Sbjct:    8 KMEVDYSLSVDNLLASIKPLLTAGNFDSAIEQCISLEKQTRTASDAISTGRLLEAIVEILAENSQWARLNEHLILMTKKHGQMKQAVSKMVQKAMEYLEKTPSEPIKLELIEALRNVTEGKIYVETERARLTKELARIKESHGDIEGAAAVLQDLQVETFGSMEKKEKVEFMLEQMRLCLAKKDFIRTQIISNKISTKFFADAENEDLKLKFYNLMIDLNAHDSLYLNISKNYWEIYNSKSIQEDEQKRLLVLRHVIIYLLLSPYDNEQHDLMCRRK--LVKDMEKIPSYFDMLKAFTTQELLKWDDFCKQYESALRAETDVFSKKGDESESETRWCDLHLRVIEHNIRVISGYYTKIRLNRLSQLLDLDVDKTEEYLSKLVVNKTVYAKIDRLEGVVHFIAKKMPTEVLNDWSYNTRNLMALINQTTHLINKERMIYGV 445

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. TrEMBL
Match: G4LX66 (Proteasome regulatory subunit-related OS=Schistosoma mansoni OX=6183 GN=Smp_058650 PE=4 SV=1)

HSP 1 Score: 456.062 bits (1172), Expect = 6.643e-155
Identity = 239/440 (54.32%), Postives = 324/440 (73.64%), Query Frame = 2

Query:   53 KMEVDYSAEVENWISEIKT---NENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPIFMNEQG-----AARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            KMEVDYS  V+N +  +K+     N   A+++    EK TR ASDAISTG+LLE  +EI A+ ++W +LNE ++L TKK  Q+KQ+V+KMVQKA EY+DK PSE  KL  I ++R+VTEGKIYVE ERAR++K LA IKE  GD+EGAAA+LQDLQVET+GSM+KKEK+EF+LEQMRLCLAKKD IRTQIIS KIS+K F D   E LKLKFY LMI+L+  ++ YLNISK+Y+EIY SKS+Q  E+ RLL L++V+++LLL+P+D+EQ+DL+ R K    KD+EK+    +++  F T+E++ W  F + YE  L+ +    +++        RW  L  R++EHNIR+++EYYT+IRL +++ +LD+     E++LS LVVNKTI AK+DRL G+ HF   K  TE++NDWSYN   L++LI +T HLINKE+M+H V
Sbjct:    8 KMEVDYSVSVDNLLVTVKSLLAAGNFESAVEQCVSLEKQTRTASDAISTGRLLEAIVEILAESSQWSRLNEHLILMTKKHGQMKQSVSKMVQKAMEYLDKTPSEPVKLELIEALRNVTEGKIYVETERARLTKELARIKESHGDIEGAAAVLQDLQVETFGSMEKKEKVEFMLEQMRLCLAKKDFIRTQIISNKISTKFFADAENEDLKLKFYNLMINLNAHDSLYLNISKNYWEIYNSKSVQEDEQKRLLVLRHVIIYLLLSPYDNEQHDLMCRRK--LVKDMEKIQIYFDMLKAFTTQELLKWDEFSKLYEHALRTETDVFSKKTDESECETRWRDLHLRVIEHNIRVISEYYTRIRLHRLSQLLDLDIDKTEEYLSKLVVNKTIYAKIDRLEGVVHFIAKKMPTEVLNDWSYNTRNLMALINQTTHLINKERMIHGV 445

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. TrEMBL
Match: A0A430Q5V2 (26S proteasome regulatory subunit N5 OS=Schistosoma bovis OX=6184 GN=DC041_0000488 PE=4 SV=1)

HSP 1 Score: 454.521 bits (1168), Expect = 2.460e-153
Identity = 240/451 (53.22%), Postives = 326/451 (72.28%), Query Frame = 2

Query:   56 MEVDYSAEVENWISEIKT---------------NENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDP-IFMNEQGAA----RWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            MEVDYS  V+N +  +K+                 N   A+++    EK TR ASDAISTG+LLE  +EI A+ ++W +LNE ++L TKK  Q+KQ+V+KMVQKA EY+DK PSE  KL  I ++R+VTEGKIYVE ERAR++K LA IKE  GD+EGAAA+LQDLQVET+GSM+KKEK+EF+LEQMRLCLAKKD IRTQIIS KIS+K F D   E LKLKFY LMI+L+  ++ YLNISK+Y+EIY SKS+Q  E+ RLL L++V+++LLL+P+D+EQ+DL+ R K    KD+EK+    +++  F T+E++ W  FC  YE  L+ +  +F+ +   +    RW  L+ R++EHNIR+++EYYT+IRL +++ +LD+     E++LS LVVNKTI AK+DRL G+ HF   K  TE++NDWSYN   L++LI +T HLINKE+M+H V
Sbjct:    1 MEVDYSVSVDNLLVTVKSLLAVRFKPDDDSLLAAGNFESAVEQCVSLEKQTRTASDAISTGRLLEAIVEILAENSQWPRLNEHLILMTKKHGQMKQSVSKMVQKAMEYLDKTPSEPVKLELIEALRNVTEGKIYVETERARLTKELARIKESHGDIEGAAAVLQDLQVETFGSMEKKEKVEFMLEQMRLCLAKKDFIRTQIISNKISTKFFADAENEDLKLKFYNLMINLNAHDSLYLNISKNYWEIYNSKSVQEDEQKRLLVLRHVIIYLLLSPYDNEQHDLMCRRK--LVKDMEKIQVYFDMLKAFTTQELLKWDEFCNLYEHVLRTETDVFLKKADESECETRWRDLRLRVIEHNIRVISEYYTRIRLHRLSQLLDLDIDKTEEYLSKLVVNKTIYAKIDRLEGVVHFIAKKMPTEVLNDWSYNTRNLMALINQTTHLINKERMIHGV 449

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. TrEMBL
Match: A0A0X3NPS0 (26S proteasome non-ATPase regulatory subunit 12 OS=Schistocephalus solidus OX=70667 GN=PSD12 PE=4 SV=1)

HSP 1 Score: 445.277 bits (1144), Expect = 1.091e-150
Identity = 237/440 (53.86%), Postives = 324/440 (73.64%), Query Frame = 2

Query:   53 KMEVDYSAEVENWIS---EIKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRD----PIFMNEQGAAR-WDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            KMEVD+SA V+  I     + +   I+EAL+K  V EK TR ASDAISTG+LL C +EI A+ N+W+KLNE +VL +KKR+QLKQAVTKMVQ A +Y+DK P+E  KL  I ++R VTEGKIYVEVERAR+++ LADIKE  G ++ AA ILQ++QVET+GSM+K+EK+EFILEQMRLCLAKKD IRTQI+SKKIS K F +E  E LKLKFY+ M+ +DL  ++YL+ISKHY+E+Y +K ++  +  +L  L+N++V+L+L+PFD+EQ+DL++R  K   +DLE L     ++  F T+E++ W  FCEK+E  L+ +     +    +G       LQ R+ EHNIRI++ YYTQIRL ++A +L +     EK+LS+LVV KT++AK+DRL  +  FT+ K AT+++NDWS+NIN L+SLI +  HLINKE+MVH V
Sbjct:    5 KMEVDFSATVDEKIPIFKSLASAGKIDEALEKCSVLEKQTRTASDAISTGRLLTCIVEILAEANQWEKLNEYLVLMSKKRNQLKQAVTKMVQAAMDYLDKTPNEPVKLGLIGTLRTVTEGKIYVEVERARLTRLLADIKESKGAIDEAADILQEIQVETFGSMEKREKVEFILEQMRLCLAKKDFIRTQILSKKISPKFFQEEGTEDLKLKFYRQMVMVDLQTDSYLSISKHYWEMYNTKMVKGDDSEKLKTLRNLVVYLILSPFDNEQHDLMHRWMKL--RDLEALPEYVCMLKAFTTQELLQWDDFCEKHEATLRNETEAFSVLNGSKGPEHALKDLQARVTEHNIRIISAYYTQIRLVRLAELLKLNVDEAEKYLSNLVVKKTVQAKIDRLDAVVRFTEKKLATDVLNDWSHNINSLMSLINQATHLINKERMVHAV 442

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. TrEMBL
Match: A0A504Z113 (26S proteasome non-ATPase regulatory subunit OS=Fasciola gigantica OX=46835 GN=FGIG_12102 PE=4 SV=1)

HSP 1 Score: 443.736 bits (1140), Expect = 6.328e-150
Identity = 239/455 (52.53%), Postives = 328/455 (72.09%), Query Frame = 2

Query:   32 MSENKILKMEVDYSAEVENWISEIKT---NENINEALDKLYVCEKLTRL----------ASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDP-IFMNEQGA----ARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVH 1342
            MS+ ++ KM+VDYS+ V+  I  +K+     NI+ AL++    EK TR+          ASDAISTG+LLE  +EI A+  +W++LN  +   TKKR+QLKQAVTKMVQK   Y+D  P EE+KL+ I S+R+VTEGKIYVEVERAR+++ LA IKE  G ++ AA++LQ+LQVET+GSM+KKEK+EF+LEQ+RL LAKKD IRTQIIS+KIS K F D   E LKLK+Y LMI+L+L ++ YLNISKHY+E+Y +KSIQ  E  RLL LK+V+V+LLLA +D+EQ+DL+ R K     D+EK+    E++  F T+E++ W  F  +Y   L  +  +F  E+       RW  L +R+VEHNIR++AEYYT+IRL +MA +LD+  +  E++LS++VVNKTI AK+DRL G+ HFT+ K  TE++NDWSYN   L++LI +  HLINKE+++H
Sbjct:    1 MSDGRLQKMDVDYSSTVDELIPVVKSLAQAGNIDGALEQCAGLEKQTRMVKLHVSNPLKASDAISTGRLLEVMVEILAEGGKWEQLNRHLETMTKKRNQLKQAVTKMVQKVLTYLDTTPDEETKLALIASLRNVTEGKIYVEVERARLTRELARIKESHGQIDEAASVLQELQVETFGSMEKKEKVEFMLEQIRLGLAKKDYIRTQIISRKISPKFFADGAHEELKLKYYHLMIELNLQDDQYLNISKHYWEVYNTKSIQEDEAKRLLALKHVIVYLLLAKYDNEQHDLMCRRK--ILGDMEKIPAYLEMLKAFTTQELLRWDDFQSQYGPILHAETDVFSTEKSPERAEKRWGDLHSRLVEHNIRVIAEYYTKIRLQRMAQLLDLDTEKAEQYLSEMVVNKTIIAKIDRLEGVVHFTETKTPTEVLNDWSYNTRSLMTLINQATHLINKERVLH 453

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Cavefish
Match: psmd12 (proteasome 26S subunit, non-ATPase 12 [Source:NCBI gene;Acc:103031840])

HSP 1 Score: 416.387 bits (1069), Expect = 1.279e-142
Identity = 225/450 (50.00%), Postives = 322/450 (71.56%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLN-LKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            S+ KI+KME+DYS+ V+  + E   +     + EA++ L   EK TR ASD +ST ++L   +++C +  +W  LNE ++L +K+RSQLKQAV KMVQ+  +Y+D      +KL  I+++R VT GKIYVE+ERAR++K LA+IKE SG+V+ AA+ILQ+LQVETYGSM+KKEK+EFILEQMRLC+A KD IRTQIISKKI++K F +E  E  KLK+Y LMI +D  E +YL+I KHY  IY +  I L + S+    LK+V+++++L+P+D+EQ+DL+  H+ S +K LE++   K+++  F T E+M W +  E Y +EL+         D    +E+G  RW  L+NR+VEHNIRIMA+YYT+I + +MA +LD+     E+FLS+LVVNKTI AKVDRL GI +F +PKD  +++NDWS+ +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 SDGKIVKMEIDYSSTVDQRLPECEKMAKEGRLQEAVEGLLSLEKQTRTASDMVSTSRILVAIVQMCYEAKDWDSLNENIMLLSKRRSQLKQAVAKMVQECYKYVDALTDLPTKLRLIDTLRTVTAGKIYVEIERARLTKTLANIKEQSGEVKEAASILQELQVETYGSMEKKEKVEFILEQMRLCIAVKDYIRTQIISKKINTKFFQEEGTEESKLKYYNLMIQVDQHEGSYLSICKHYRAIYDTPCI-LEDSSKWQQALKSVVLYVVLSPYDNEQSDLV--HRISTDKKLEEIPKYKDLLKQFTTMELMRWSSLVEDYGKELREGSPDSPATDVFTYSEEGEKRWQDLKNRVVEHNIRIMAKYYTRITMKRMAGLLDLSIDESEEFLSNLVVNKTIYAKVDRLAGIINFQRPKDPNDLLNDWSHKLNSLMSLVNKTTHLIAKEEMIHNL 455

[Close]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Cavefish
Match: psmd12 (proteasome 26S subunit, non-ATPase 12 [Source:NCBI gene;Acc:103031840])

HSP 1 Score: 414.846 bits (1065), Expect = 1.051e-141
Identity = 223/449 (49.67%), Postives = 318/449 (70.82%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            S+ KI+KME+DYS+ V+  + E   +     + EA++ L   EK TR ASD +ST ++L   +++C +  +W  LNE ++L +K+RSQLKQAV KMVQ+  +Y+D      +KL  I+++R VT GKIYVE+ERAR++K LA+IKE SG+V+ AA+ILQ+LQVETYGSM+KKEK+EFILEQMRLC+A KD IRTQIISKKI++K F +E  E  KLK+Y LMI +D  E +YL+I KHY  IY +  I          LK+V+++++L+P+D+EQ+DL+  H+ S +K LE++   K+++  F T E+M W +  E Y +EL+         D    +E+G  RW  L+NR+VEHNIRIMA+YYT+I + +MA +LD+     E+FLS+LVVNKTI AKVDRL GI +F +PKD  +++NDWS+ +N L+SL+ KT HLI KE+M+H++
Sbjct:   34 SDGKIVKMEIDYSSTVDQRLPECEKMAKEGRLQEAVEGLLSLEKQTRTASDMVSTSRILVAIVQMCYEAKDWDSLNENIMLLSKRRSQLKQAVAKMVQECYKYVDALTDLPTKLRLIDTLRTVTAGKIYVEIERARLTKTLANIKEQSGEVKEAASILQELQVETYGSMEKKEKVEFILEQMRLCIAVKDYIRTQIISKKINTKFFQEEGTEESKLKYYNLMIQVDQHEGSYLSICKHYRAIYDTPCILEDSSKWQQALKSVVLYVVLSPYDNEQSDLV--HRISTDKKLEEIPKYKDLLKQFTTMELMRWSSLVEDYGKELREGSPDSPATDVFTYSEEGEKRWQDLKNRVVEHNIRIMAKYYTRITMKRMAGLLDLSIDESEEFLSNLVVNKTIYAKVDRLAGIINFQRPKDPNDLLNDWSHKLNSLMSLVNKTTHLIAKEEMIHNL 480

[Close]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Cavefish
Match: psmd12 (proteasome 26S subunit, non-ATPase 12 [Source:NCBI gene;Acc:103031840])

HSP 1 Score: 406.371 bits (1043), Expect = 5.616e-139
Identity = 219/446 (49.10%), Postives = 312/446 (69.96%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISEIKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            S+ KI+KME+DYS+ V+  + E                CEK+ + ASD +ST ++L   +++C +  +W  LNE ++L +K+RSQLKQAV KMVQ+  +Y+D      +KL  I+++R VT GKIYVE+ERAR++K LA+IKE SG+V+ AA+ILQ+LQVETYGSM+KKEK+EFILEQMRLC+A KD IRTQIISKKI++K F +E  E  KLK+Y LMI +D  E +YL+I KHY  IY +  I          LK+V+++++L+P+D+EQ+DL+  H+ S +K LE++   K+++  F T E+M W +  E Y +EL+         D    +E+G  RW  L+NR+VEHNIRIMA+YYT+I + +MA +LD+     E+FLS+LVVNKTI AKVDRL GI +F +PKD  +++NDWS+ +N L+SL+ KT HLI KE+M+H++
Sbjct:    9 SDGKIVKMEIDYSSTVDQRLPE----------------CEKMAK-ASDMVSTSRILVAIVQMCYEAKDWDSLNENIMLLSKRRSQLKQAVAKMVQECYKYVDALTDLPTKLRLIDTLRTVTAGKIYVEIERARLTKTLANIKEQSGEVKEAASILQELQVETYGSMEKKEKVEFILEQMRLCIAVKDYIRTQIISKKINTKFFQEEGTEESKLKYYNLMIQVDQHEGSYLSICKHYRAIYDTPCILEDSSKWQQALKSVVLYVVLSPYDNEQSDLV--HRISTDKKLEEIPKYKDLLKQFTTMELMRWSSLVEDYGKELREGSPDSPATDVFTYSEEGEKRWQDLKNRVVEHNIRIMAKYYTRITMKRMAGLLDLSIDESEEFLSNLVVNKTIYAKVDRLAGIINFQRPKDPNDLLNDWSHKLNSLMSLVNKTTHLIAKEEMIHNL 435

[Close]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Sea Lamprey
Match: psmd12 (proteasome 26S subunit, non-ATPase 12 [Source:ZFIN;Acc:ZDB-GENE-030131-617])

HSP 1 Score: 305.064 bits (780), Expect = 1.210e-101
Identity = 163/323 (50.46%), Postives = 234/323 (72.45%), Query Frame = 2

Query:  404 KIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKR--------DPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            +IYVE+ERAR+++ LA  KE  G++  A+ ILQ+LQVET+GSM+KKEK+EFILEQMRLCLA KD IRTQIISKKI++K F +EN E LKLK+Y LMI LD  E +YL+I KHY  IY +  IQ         +K+ +++++LA +D+EQ+DL+  H+ + +K LE+L   +EI+ LF T E+M W    EKY ++L++        D    +++G  RW  L+NR+VEHNIR+MA+YYT+I + +MA +LD+     E+FLS LVV+KT+ AKVDRL G+ +F +PKD  +++NDWS+ +N L++L+ KT HLI KE+M+H++
Sbjct:    1 QIYVEIERARLTRILAKFKEEKGELVEASNILQELQVETFGSMEKKEKVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEELKLKYYDLMIQLDQHEGSYLSICKHYRAIYDTPCIQAERAKWQQVMKSAILYVVLAAYDNEQSDLV--HRVNQDKKLEELPKYREILKLFTTSELMHWGTLVEKYGKDLRKGTADNPATDVFSYSQEGEKRWQVLKNRVVEHNIRVMAKYYTRISMQRMAELLDLSIDESEEFLSRLVVSKTVFAKVDRLAGVINFQRPKDPNDLLNDWSHKLNALMALVNKTTHLIAKEEMIHNL 321

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001661.1 (pep scaffold:Pmarinus_7.0:GL490297:12:1788:-1 gene:ENSPMAG00000001500.1 transcript:ENSPMAT00000001661.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 92.4337 bits (228), Expect = 7.054e-23
Identity = 48/103 (46.60%), Postives = 67/103 (65.05%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEY 334
             + KI+KMEVDYS  V+  + E   +     + EA+D L   EK TR ASD +ST ++L   ++IC +  +W  LNE +++ TK+RSQLKQAV KMVQ+ CEY
Sbjct:    9 GDGKIVKMEVDYSPVVDQRLPESRKMAEEGKLQEAIDNLLSLEKQTRTASDMVSTSRILVGIVQICFEAKDWDALNENIIIMTKRRSQLKQAVAKMVQQCCEY 111

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BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Yeast
Match: RPN5 (Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN [Source:SGD;Acc:S000002306])

HSP 1 Score: 302.753 bits (774), Expect = 3.409e-99
Identity = 178/442 (40.27%), Postives = 286/442 (64.71%), Query Frame = 2

Query:   32 MSENKILKMEVDYSAEVENWISEIKT--NENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEE--SKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPI-FMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVH 1342
            MS +  +K + DYS  ++    +I +    + N ALD+L V EK TR ASD  S+ ++L   +++ A RN+W  LNE + L +KK  QLK ++  M+QK  EY+  + S +  +++S I +IR VTE KI+VEVERARV+K L +IK+  G ++ AA IL +LQVETYGSM+  EKI+FILEQM L + K D  +  ++S+KI  K+F +  +E LKL++Y L++ + L +  YL ++++  EIYQ+ +I+  E      L +++ FL+L+P+ + QNDL+  HK   + +L+KL + + ++ LF T E+M W    + YE  L  D + F  E     W+ LQ R++EHN+R+++EYY++I L ++  +LD+ E   E ++SDLV    I AKV+R   I +F KPK++++++N+WS+N+++LL  I+   HLI KE+++H
Sbjct:    1 MSRDAPIKADKDYSQILKEEFPKIDSLAQNDCNSALDQLLVLEKKTRQASDLASSKEVLAKIVDLLASRNKWDDLNEQLTLLSKKHGQLKLSIQYMIQKVMEYLKSSKSLDLNTRISVIETIRVVTENKIFVEVERARVTKDLVEIKKEEGKIDEAADILCELQVETYGSMEMSEKIQFILEQMELSILKGDYSQATVLSRKILKKTFKNPKYESLKLEYYNLLVKISLHKREYLEVAQYLQEIYQTDAIKSDEAKWKPVLSHIVYFLVLSPYGNLQNDLI--HKIQNDNNLKKLESQESLVKLFTTNELMRWPIVQKTYEPVLNEDDLAFGGEANKHHWEDLQKRVIEHNLRVISEYYSRITLLRLNELLDLTESQTETYISDLVNQGIIYAKVNRPAKIVNFEKPKNSSQLLNEWSHNVDELLEHIETIGHLITKEEIMH 440

[Close]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Nematostella
Match: EDO38521 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCN9])

HSP 1 Score: 397.127 bits (1019), Expect = 1.145e-135
Identity = 217/440 (49.32%), Postives = 308/440 (70.00%), Query Frame = 2

Query:   47 ILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQ-VETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPIFM----NEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVH 1342
            ++KMEVDYS  V+  I E   +     + E+LD L   EK TR A+D  ST ++L C +++C    +W  LNE ++L TK+RSQLKQAVTKM+Q++  YID+ P  E+KL  I+++R VT GKIYVE+ERAR++  LA IKE  G++  AA ILQ+LQ VET+GSM++KEK+EFI+EQMRLCLAKKD IRTQIISKKIS K F  +  + LKLK+Y+L+I+L   E+NYL   KHY  IY++  I   +E +   LK+V++FL+LAPFD+EQ+DLL+R K+  +K LE++   KE++  F T E+M W    ++Y  EL    + +     + G  RWD L+ R+VEHNIR+MA+YYT+I +T++A +L++  +  E FLS+LVV+KT+ A++DR  GI  F+  K   EI+N+WS+N+  L+ L+ +T HLI KE+MVH
Sbjct:    5 VVKMEVDYSETVDKRIPECEALAAEGKLTESLDILLSLEKQTRTAADMHSTARILVCIVQLCFKAQDWNALNEHIILLTKRRSQLKQAVTKMIQESYTYIDQTPDMETKLKLIDTLRTVTAGKIYVEIERARLTMMLAKIKENEGNITEAANILQELQVVETFGSMERKEKVEFIMEQMRLCLAKKDYIRTQIISKKISPKFFDGDKEQDLKLKYYQLLIELADQESNYLATCKHYKAIYETPIITEDKEKKHQALKHVVLFLVLAPFDNEQSDLLHRVKE--DKTLEEIPLYKELLKCFTTSELMNWAHVQQQYGPELHGSALGVFDTNTDNGKKRWDDLRKRVVEHNIRVMAKYYTRISMTRIAQLLNLTVEESEHFLSELVVSKTVFARIDRPSGIVTFSSNKSPNEILNEWSHNLTTLMQLLNRTTHLITKEEMVH 442

[Close]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Nematostella
Match: EDO29191 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T4C0])

HSP 1 Score: 259.225 bits (661), Expect = 9.077e-83
Identity = 158/359 (44.01%), Postives = 230/359 (64.07%), Query Frame = 2

Query:   38 ENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQ-VETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLK------LKFYKLMIDLDLSENNYLN--ISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPIFM----NEQGAARWDQLQNRIVEH 1066
            +  ++KMEVDYS  V+  I E   +     + E+LD L   EK TR A+D  ST ++L C +++C    +W  LNE + L TK+RSQLKQAVTKM+Q++  YID+ P  E+KL  I+++R VT GKIYVE+ERAR++  LA IKE  G++  AA ILQ+LQ VET+GSM++KEK+EFI+EQMRLCLAKKD IRTQ I  K  S  F D + E +       + FY   I L + +  YL+    K    I+++ ++  +++++   LK+V++FL+LAPFD+EQ+DLL+R K+  +K LE++   KE++  F T E+M W    ++Y  EL    + +     + G  RWD L+ R+VEH
Sbjct:    2 KGNVVKMEVDYSETVDKRIPECEALAAEGKLTESLDILLSLEKQTRTAADMHSTARILVCIVQLCFKAKDWNALNEHINLLTKRRSQLKQAVTKMIQESYMYIDQTPDMETKLKLIDTLRTVTAGKIYVEIERARLTMMLAKIKENEGNITEAANILQELQVVETFGSMERKEKVEFIMEQMRLCLAKKDYIRTQ-IISKKISPKFFDGDKEQVHGIHRNDIIFYPYQIILTVIKGMYLSDLFLKRQMSIFKNCNVDDNKQAK-GALKHVVLFLVLAPFDNEQSDLLHRVKE--DKTLEEIPLYKELLKCFTTSELMNWAHVQQQYGPELHGSALGVFDTNTDNGKKRWDDLRKRVVEH 356

[Close]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Nematostella
Match: EDO26121 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TCU1])

HSP 1 Score: 159.458 bits (402), Expect = 3.319e-46
Identity = 95/235 (40.43%), Postives = 152/235 (64.68%), Query Frame = 2

Query:  665 LKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTK-EVMLWRAFCEKY--EQELKRDPIFMNEQGAARWDQLQNRI------VEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVH 1342
            LKLK+Y+L+I+L   E+NYL   KHY  IY++  I   +E +   LK+V++FL+LAPFD+EQ+DLL+R K+  +K LE++   K  + L   + EV + +  C K   +++++ D I +N +        Q  +      + +NIR+MA+YYT+I +T+MA +L++  +  E FLS+LVV+KT+ A++DR  GI  F+  K   EI+N+WS+N+  L+ L+ +T HLI KE+MVH
Sbjct:    3 LKLKYYQLLIELADQESNYLATCKHYKAIYETPIITEDKEKKHQALKHVVLFLVLAPFDNEQSDLLHRVKE--DKTLEEIPLYKIDLSLNSFELEVCMQQTLCLKIADKKDIQTDNIRINTKRTQLSQSSQTIMTILIAPIANNIRVMAKYYTRISMTRMAQLLNLTVEESEHFLSELVVSKTVFARIDRPSGIVTFSSNKSPNEILNEWSHNLTTLMQLLNRTTHLITKEEMVH 235

[Close]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Medaka
Match: psmd12 (proteasome 26S subunit, non-ATPase 12 [Source:NCBI gene;Acc:101161219])

HSP 1 Score: 420.239 bits (1079), Expect = 4.917e-144
Identity = 227/449 (50.56%), Postives = 318/449 (70.82%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISE---IKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELK--------RDPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            S+ KI+KMEVDYS+ V+  + E   +  +  + EA++ L   EK TR ASD IST ++L   +++C +  +W  LNE ++L +K+RSQLKQAV KMVQ+  +Y+D       KL  I+++R VT GKIYVE+ERAR++K LA+IKE +GDV+ AAAILQ+LQVETYGSM+KKEK EFILEQMRLC+A KD +RTQIISKKI++K F DE  E LKLK+Y LMI +D  E++YL+I KHY  IY +  I          LK+V+++++L+P+D+EQ+DL+  H+ S +K LE++   K+++  F T E+M W +  E Y +EL+         D    +E G  RW  L+NR+VEHNIRIMA+YYT+I + +MA++LD+     E+FLS LVVNKTI AKVDRL GI +F +PKD  +++NDWS+ +N L+SL+ KT HLI KE+M+H++
Sbjct:   10 SDGKIVKMEVDYSSTVDQRLPECEKMAKDGKLQEAVESLLSLEKQTRTASDMISTSRILVAVVQLCYEAKDWDALNENIMLLSKRRSQLKQAVAKMVQECYKYVDAMSDLTIKLRLIDTLRTVTAGKIYVEIERARLTKTLANIKEQNGDVKEAAAILQELQVETYGSMEKKEKAEFILEQMRLCIAVKDYVRTQIISKKINTKFFQDEGTEELKLKYYNLMIQVDQHEDSYLSICKHYRAIYDTPCILEKSSEWQQALKSVVLYVILSPYDNEQSDLV--HRISADKKLEEIPKYKDLLKQFTTMELMRWASLVEDYGKELRDGSPDSPATDVFSYSEDGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMANLLDLSIDESEEFLSSLVVNKTIYAKVDRLAGIINFQRPKDPNDLLNDWSHKLNSLMSLVNKTTHLIAKEEMIHNL 456

[Close]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Medaka
Match: psmd12 (proteasome 26S subunit, non-ATPase 12 [Source:NCBI gene;Acc:101161219])

HSP 1 Score: 387.497 bits (994), Expect = 1.879e-131
Identity = 218/454 (48.02%), Postives = 306/454 (67.40%), Query Frame = 2

Query:   35 SENKILKMEVDYSAEVENWISEIKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVER--------ARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELK--------RDPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHV 1348
            S+ KI+KMEVDYS+ V+  + E                CEK+ + ASD IST ++L   +++C +  +W  LNE ++L +K+RSQLKQAV KMVQ+  +Y+D       KL  I+++R VT G     +ER        AR++K LA+IKE +GDV+ AAAILQ+LQVETYGSM+KKEK EFILEQMRLC+A KD +RTQIISKKI++K F DE  E LKLK+Y LMI +D  E++YL+I KHY  IY +  I          LK+V+++++L+P+D+EQ+DL+  H+ S +K LE++   K+++  F T E+M W +  E Y +EL+         D    +E G  RW  L+NR+VEHNIRIMA+YYT+I + +MA++LD+     E+FLS LVVNKTI AKVDRL GI +F +PKD  +++NDWS+ +N L+SL+ KT HLI KE+M+H++
Sbjct:   10 SDGKIVKMEVDYSSTVDQRLPE----------------CEKMAK-ASDMISTSRILVAVVQLCYEAKDWDALNENIMLLSKRRSQLKQAVAKMVQECYKYVDAMSDLTIKLRLIDTLRTVTAGSPSCCIERHEYFINCRARLTKTLANIKEQNGDVKEAAAILQELQVETYGSMEKKEKAEFILEQMRLCIAVKDYVRTQIISKKINTKFFQDEGTEELKLKYYNLMIQVDQHEDSYLSICKHYRAIYDTPCILEKSSEWQQALKSVVLYVILSPYDNEQSDLV--HRISADKKLEEIPKYKDLLKQFTTMELMRWASLVEDYGKELRDGSPDSPATDVFSYSEDGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMANLLDLSIDESEEFLSSLVVNKTIYAKVDRLAGIINFQRPKDPNDLLNDWSHKLNSLMSLVNKTTHLIAKEEMIHNL 444

[Close]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Planmine SMEST
Match: SMESG000057467.1 (SMESG000057467.1)

HSP 1 Score: 872.463 bits (2253), Expect = 0.000e+0
Identity = 439/440 (99.77%), Postives = 440/440 (100.00%), Query Frame = 2

Query:   32 MSENKILKMEVDYSAEVENWISEIKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQXXXXXXXXXXFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHVA 1351
            MSENKILKMEVDYSAEVENWISEIKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEE+KLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQIISKKISSKSFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHVA
Sbjct:    1 MSENKILKMEVDYSAEVENWISEIKTNENINEALDKLYVCEKLTRLASDAISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACEYIDKAPSEETKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVEGAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQIISKKISSKSFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSEESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIILFCTKEVMLWRAFCEKYEQELKRDPIFMNEQGAARWDQLQNRIVEHNIRIMAEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFTKPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHVA 440

The following BLAST results are available for this feature:

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Human
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Celegans
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Fly
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Zebrafish
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Xenopus
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Mouse
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. UniProt/SwissProt
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. TrEMBL
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Cavefish
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Sea Lamprey
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Yeast
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Nematostella
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Medaka
BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Planmine SMEST

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
PSMD12	1.438e-147	51.67	proteasome 26S subunit, non-ATPase 12 [Source:HGNC...	[more]
PSMD12	6.382e-144	51.35	proteasome 26S subunit, non-ATPase 12 [Source:HGNC...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
rpn-5	9.932e-84	37.47	Proteasome Regulatory Particle, Non-ATPase-like [...	[more]
rpn-5	9.932e-84	37.47	Proteasome Regulatory Particle, Non-ATPase-like [...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Rpn5	3.743e-110	40.73	gene:FBgn0028690 transcript:FBtr0078629	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
psmd12	2.637e-144	50.78	proteasome 26S subunit, non-ATPase 12 [Source:ZFIN...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Psmd12	2.642e-146	51.00	proteasome (prosome, macropain) 26S subunit, non-A...	[more]
Psmd12	2.368e-143	50.90	proteasome (prosome, macropain) 26S subunit, non-A...	[more]
Psmd12	2.516e-115	50.13	proteasome (prosome, macropain) 26S subunit, non-A...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q2KJ25\|PSD12_BOVIN	6.611e-147	51.67	26S proteasome non-ATPase regulatory subunit 12 OS...	[more]
sp\|O00232\|PSD12_HUMAN	6.905e-147	51.67	26S proteasome non-ATPase regulatory subunit 12 OS...	[more]
sp\|Q5RBI3\|PSD12_PONAB	2.781e-146	51.45	26S proteasome non-ATPase regulatory subunit 12 OS...	[more]
sp\|Q9D8W5\|PSD12_MOUSE	1.848e-145	51.00	26S proteasome non-ATPase regulatory subunit 12 OS...	[more]
sp\|Q12250\|RPN5_YEAST	2.367e-97	40.27	26S proteasome regulatory subunit RPN5 OS=Saccharo...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C1LIY4	1.001e-157	55.00	26S proteasome non-ATPase regulatory subunit 12 is...	[more]
G4LX66	6.643e-155	54.32	Proteasome regulatory subunit-related OS=Schistoso...	[more]
A0A430Q5V2	2.460e-153	53.22	26S proteasome regulatory subunit N5 OS=Schistosom...	[more]
A0A0X3NPS0	1.091e-150	53.86	26S proteasome non-ATPase regulatory subunit 12 OS...	[more]
A0A504Z113	6.328e-150	52.53	26S proteasome non-ATPase regulatory subunit OS=Fa...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
psmd12	1.279e-142	50.00	proteasome 26S subunit, non-ATPase 12 [Source:NCBI...	[more]
psmd12	1.051e-141	49.67	proteasome 26S subunit, non-ATPase 12 [Source:NCBI...	[more]
psmd12	5.616e-139	49.10	proteasome 26S subunit, non-ATPase 12 [Source:NCBI...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
psmd12	1.210e-101	50.46	proteasome 26S subunit, non-ATPase 12 [Source:ZFIN...	[more]
ENSPMAT00000001661.1	7.054e-23	46.60	pep scaffold:Pmarinus_7.0:GL490297:12:1788:-1 gene...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
RPN5	3.409e-99	40.27	Subunit of the CSN and 26S proteasome lid complexe...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO38521	1.145e-135	49.32	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO29191	9.077e-83	44.01	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO26121	3.319e-46	40.43	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
psmd12	4.917e-144	50.56	proteasome 26S subunit, non-ATPase 12 [Source:NCBI...	[more]
psmd12	1.879e-131	48.02	proteasome 26S subunit, non-ATPase 12 [Source:NCBI...	[more]

BLAST of 26S proteasome non-ATPase regulatory subunit 12 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000057467.1	0.000e+0	99.77	SMESG000057467.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30008839 ID=SMED30008839|Name=26S proteasome non-ATPase regulatory subunit 12|organism=Schmidtea mediterranea sexual|type=transcript|length=1355bp
TTTTTCAAAATTTCATTAATCGCTTAACAAAATGTCTGAAAATAAGATTT
TGAAAATGGAGGTAGATTATTCTGCCGAAGTTGAAAATTGGATAAGTGAA
ATAAAAACTAATGAGAATATTAACGAAGCGTTGGATAAATTATATGTCTG
TGAGAAATTAACTAGATTGGCTTCCGATGCCATATCTACTGGAAAGTTAT
TAGAATGTGGTATTGAAATCTGTGCAGACAGAAATGAGTGGAAAAAACTG
AACGAAATCATGGTATTATTTACTAAAAAGAGAAGTCAATTAAAGCAAGC
AGTCACTAAAATGGTTCAAAAAGCTTGCGAATATATAGATAAAGCTCCAA
GTGAAGAATCAAAATTGAGCTTTATCAATTCAATTCGGGATGTCACAGAA
GGAAAAATTTATGTTGAAGTAGAAAGAGCAAGAGTTAGTAAACGATTAGC
AGACATTAAAGAAGGTAGTGGAGATGTAGAGGGAGCTGCAGCGATTTTGC
AAGATCTACAAGTAGAGACATATGGATCTATGGATAAAAAGGAAAAAATT
GAATTTATTCTCGAGCAAATGCGATTATGTTTAGCAAAAAAAGATGCTAT
TAGAACGCAAATTATTAGTAAAAAAATTTCTTCCAAGTCGTTCATTGATG
AAAATTTTGAGCCATTAAAATTAAAATTCTATAAGTTGATGATAGATTTA
GATTTATCGGAAAATAATTACTTAAACATCAGTAAGCATTATTTCGAAAT
TTATCAATCTAAGTCGATCCAATTATCCGAAGAGAGTAGGTTGTTGAATT
TAAAAAATGTTATGGTTTTCTTGTTATTGGCTCCATTTGATCACGAGCAA
AATGACCTTTTATATAGACATAAAAAGTCGTGTGAAAAAGATTTGGAAAA
ACTGTCGACAATCAAGGAAATTATTATACTTTTCTGCACCAAGGAGGTCA
TGTTGTGGCGTGCATTCTGTGAGAAATACGAGCAAGAATTGAAGCGAGAT
CCGATTTTTATGAATGAGCAAGGCGCTGCACGATGGGACCAATTGCAAAA
TCGAATTGTCGAGCACAATATTCGAATCATGGCGGAATATTACACTCAAA
TCCGGTTGACCAAAATGGCCAGCATGCTCGATATCGGCGAGAAAACCCTG
GAGAAGTTTCTATCTGATTTGGTTGTTAACAAAACAATTGAAGCTAAGGT
CGACCGGCTATTGGGAATCGCTCATTTTACCAAGCCCAAAGATGCCACTG
AGATCGTTAATGATTGGTCGTACAATATCAACCAATTACTGAGCTTGATC
AAAAAGACCAATCATTTGATTAATAAAGAAAAAATGGTTCACCACGTTGC
GTAAT

protein sequence of SMED30008839-orf-1

>SMED30008839-orf-1 ID=SMED30008839-orf-1|Name=SMED30008839-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=441bp
MSENKILKMEVDYSAEVENWISEIKTNENINEALDKLYVCEKLTRLASDA
ISTGKLLECGIEICADRNEWKKLNEIMVLFTKKRSQLKQAVTKMVQKACE
YIDKAPSEESKLSFINSIRDVTEGKIYVEVERARVSKRLADIKEGSGDVE
GAAAILQDLQVETYGSMDKKEKIEFILEQMRLCLAKKDAIRTQIISKKIS
SKSFIDENFEPLKLKFYKLMIDLDLSENNYLNISKHYFEIYQSKSIQLSE
ESRLLNLKNVMVFLLLAPFDHEQNDLLYRHKKSCEKDLEKLSTIKEIIIL
FCTKEVMLWRAFCEKYEQELKRDPIFMNEQGAARWDQLQNRIVEHNIRIM
AEYYTQIRLTKMASMLDIGEKTLEKFLSDLVVNKTIEAKVDRLLGIAHFT
KPKDATEIVNDWSYNINQLLSLIKKTNHLINKEKMVHHVA*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000429	neoblast
PLANA:0002109	X1 cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036388	WH-like_DNA-bd_sf
IPR040896	RPN5_C
IPR040134	PSMD12/CSN4
IPR035297	PSMD12
IPR036390	WH_DNA-bd_sf
IPR000717	PCI_dom
IPR011991	WHTH_DNA-bd_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding

Vocabulary: **biological process**
Term	Definition
GO:0000165	MAPK cascade
GO:0000209	protein polyubiquitination
GO:0002223	stimulatory C-type lectin receptor signaling pathway
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006521	regulation of cellular amino acid metabolic process
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle
GO:0016579	protein deubiquitination
GO:0031145	anaphase-promoting complex-dependent catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0038061	NIK/NF-kappaB signaling
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043312	neutrophil degranulation
GO:0043488	regulation of mRNA stability
GO:0050852	T cell receptor signaling pathway
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0055085	transmembrane transport
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway

Vocabulary: **cellular component**
Term	Definition
GO:0000502	proteasome complex
GO:0005576	extracellular region
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005838	proteasome regulatory particle
GO:0008541	proteasome regulatory particle, lid subcomplex
GO:0016020	membrane
GO:0022624	proteasome accessory complex
GO:0031595	nuclear proteasome complex
GO:0034774	secretory granule lumen
GO:0070062	extracellular exosome
GO:1904813	ficolin-1-rich granule lumen

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000717	Proteasome component (PCI) domain	SMART	SM00088	PINT_4	coord: 333..419 e-value: 2.4E-15 score: 67.0
IPR000717	Proteasome component (PCI) domain	PFAM	PF01399	PCI	coord: 294..400 e-value: 3.6E-17 score: 62.8
IPR000717	Proteasome component (PCI) domain	PROSITE	PS50250	PCI	coord: 229..404 score: 17.687
None	No IPR available	SMART	SM00753	PINT	coord: 333..419 e-value: 2.4E-15 score: 67.0
IPR036388	Winged helix-like DNA-binding domain superfamily	GENE3D	G3DSA:1.10.10.10		coord: 330..408 e-value: 1.0E-12 score: 49.5
IPR040896	26S proteasome regulatory subunit RPN5, C-terminal domain	PFAM	PF18098	RPN5_C	coord: 407..437 e-value: 1.3E-14 score: 54.0
IPR040134	26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4	PANTHER	PTHR10855	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4	coord: 3..437
IPR035297	26S Proteasome non-ATPase regulatory subunit 12	PANTHER	PTHR10855:SF1	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12	coord: 3..437
IPR036390	Winged helix DNA-binding domain superfamily	SUPERFAMILY	SSF46785	"Winged helix" DNA-binding domain	coord: 331..408

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26S proteasome non-ATPase regulatory subunit 12

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

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