E3 ubiquitin-protein ligase UBR5

Overview


Name	E3 ubiquitin-protein ligase UBR5
Smed ID	SMED30008783
Length (bp)	11230

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of E3 ubiquitin-protein ligase UBR5 (SMED30008783) t-SNE clustered cells

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase UBR5 (SMED30008783) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 ubiquitin-protein ligase UBR5 (SMED30008783) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase UBR5 (SMED30008783) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30008783

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30008783	h1SMcG0009486	dd_Smed_v4_7658_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30008783	h1SMcG0009486	dd_Smed_v4_7658_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Category 3 cell	SMED30008783	h1SMcG0009486	GAKN01005557.1	SmedAsxl_pearson_GAKN01	PMID:25956527 Henderson et al., 2015
central nervous system	SMED30008783	h1SMcG0009486	GAKN01005557.1	SmedAsxl_pearson_GAKN01	PMID:25956527 Henderson et al., 2015
parenchyma	SMED30008783	h1SMcG0009486	GAKN01005557.1	SmedAsxl_pearson_GAKN01	PMID:25956527 Henderson et al., 2015
cephalic ganglia	SMED30008783	h1SMcG0009486	KP954686	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015
ventral nerve cord	SMED30008783	h1SMcG0009486	KP954686	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015
neoblast	SMED30008783	h1SMcG0009486	KP954686	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015
parenchymal cell	SMED30008783	h1SMcG0009486	KP954686	smed_ncbi_20240424	PMID:25956527 Henderson et al., 2015

Note: Hover over icons to view figure legend

Homology

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Human
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:HGNC Symbol;Acc:HGNC:16806])

HSP 1 Score: 323.168 bits (827), Expect = 9.619e-96
Identity = 160/326 (49.08%), Postives = 219/326 (67.18%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL+  ++ +    +  A        +L F I   +EEGG              + LIPNG ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK++L  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct:  230 APLFYQPGKRGFYTPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSA-------MDLAFAIDLCKEEGGG------------QVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 527

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Human
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:HGNC Symbol;Acc:HGNC:16806])

HSP 1 Score: 330.487 bits (846), Expect = 1.493e-89
Identity = 200/504 (39.68%), Postives = 290/504 (57.54%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   + +S    +  + + M+ P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L TLPN R EHLLLFLV+TV RQ  EH Q R    R           +    TAS   S            MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1073 PSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAE-ISSSEKEEDVFMGMVCPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE----------DRNRKTASPEDS-----------DMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAIAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1514

HSP 2 Score: 324.324 bits (830), Expect = 1.230e-87
Identity = 160/326 (49.08%), Postives = 219/326 (67.18%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL+  ++ +    +  A        +L F I   +EEGG              + LIPNG ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK++L  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2501 APLFYQPGKRGFYTPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSA-------MDLAFAIDLCKEEGGG------------QVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2798

HSP 3 Score: 224.942 bits (572), Expect = 1.488e-57
Identity = 174/497 (35.01%), Postives = 259/497 (52.11%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSS---MANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVN 2026
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R    S   S   +   +E  ++  + R    +LR       R + DG    +  G+ S    P+   KN  TPV ++ + LG +L++W +K          KFI I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T + K+ATWVDET++ +                ++EH    +SEL+ E I  L    L +  +  + ++YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL N
Sbjct:  157 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPNLDKKN--TPV-QSPVSLGEDLQWWPDK-------DGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNA---------QNPSL---------------HHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVAS--------------KLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKN 584

HSP 4 Score: 154.066 bits (388), Expect = 4.260e-36
Identity = 126/390 (32.31%), Postives = 179/390 (45.90%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYD-GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                    +N  C     NS+ P++ DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS+  FLG+                  +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P       N T K   +      V ++ +E QTLM HILR D +     + N   AV  E +   +Q  IS + DG RNI+H  V++C P SN
Sbjct:  632 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS--------------------SNTNCQ----NSSGPDA-DPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLK---TGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQ----------------NERNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLIN-------LPA------NSTIKKKAA------VIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN 935

HSP 5 Score: 152.525 bits (384), Expect = 1.356e-35
Identity = 104/291 (35.74%), Postives = 143/291 (49.14%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRN-----------------TINNQNFCGRSNEGQ--LPLHM-----GFSSRWADRLLDNNIIFS-------GVPVGNLRT----------------RWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN                  +N QN   +  E Q  LP        G S+      L ++++         G P+ + R                 RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDLSL V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2022 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL 2309

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Human
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:HGNC Symbol;Acc:HGNC:16806])

HSP 1 Score: 330.487 bits (846), Expect = 1.515e-89
Identity = 200/504 (39.68%), Postives = 290/504 (57.54%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   + +S    +  + + M+ P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L TLPN R EHLLLFLV+TV RQ  EH Q R    R           +    TAS   S            MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1067 PSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAE-ISSSEKEEDVFMGMVCPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE----------DRNRKTASPEDS-----------DMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAIAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1508

HSP 2 Score: 323.939 bits (829), Expect = 1.345e-87
Identity = 160/326 (49.08%), Postives = 219/326 (67.18%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL+  ++ +    +  A        +L F I   +EEGG              + LIPNG ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK++L  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2495 APLFYQPGKRGFYTPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSA-------MDLAFAIDLCKEEGGG------------QVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2792

HSP 3 Score: 225.328 bits (573), Expect = 1.136e-57
Identity = 174/494 (35.22%), Postives = 259/494 (52.43%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVN 2026
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS    R S  S + +  E  ++  + R    +LR       R + DG    +  G+ S    P+   KN  TPV ++ + LG +L++W +K          KFI I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T + K+ATWVDET++ +                ++EH    +SEL+ E I  L    L +  +  + ++YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL N
Sbjct:  157 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSF---RRSSLSRLGSSRERDSELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPNLDKKN--TPV-QSPVSLGEDLQWWPDK-------DGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNA---------QNPSL---------------HHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVAS--------------KLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKN 578

HSP 4 Score: 154.066 bits (388), Expect = 4.222e-36
Identity = 126/390 (32.31%), Postives = 179/390 (45.90%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYD-GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                    +N  C     NS+ P++ DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS+  FLG+                  +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P       N T K   +      V ++ +E QTLM HILR D +     + N   AV  E +   +Q  IS + DG RNI+H  V++C P SN
Sbjct:  626 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS--------------------SNTNCQ----NSSGPDA-DPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLK---TGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQ----------------NERNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLIN-------LPA------NSTIKKKAA------VIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN 929

HSP 5 Score: 152.525 bits (384), Expect = 1.278e-35
Identity = 104/291 (35.74%), Postives = 143/291 (49.14%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRN-----------------TINNQNFCGRSNEGQ--LPLHM-----GFSSRWADRLLDNNIIFS-------GVPVGNLRT----------------RWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN                  +N QN   +  E Q  LP        G S+      L ++++         G P+ + R                 RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDLSL V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2016 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL 2303

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Human
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:HGNC Symbol;Acc:HGNC:16806])

HSP 1 Score: 330.487 bits (846), Expect = 1.532e-89
Identity = 200/504 (39.68%), Postives = 290/504 (57.54%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   + +S    +  + + M+ P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L TLPN R EHLLLFLV+TV RQ  EH Q R    R           +    TAS   S            MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1073 PSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAE-ISSSEKEEDVFMGMVCPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE----------DRNRKTASPEDS-----------DMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAIAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1514

HSP 2 Score: 323.939 bits (829), Expect = 1.272e-87
Identity = 160/326 (49.08%), Postives = 219/326 (67.18%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL+  ++ +    +  A        +L F I   +EEGG              + LIPNG ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK++L  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2502 APLFYQPGKRGFYTPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSA-------MDLAFAIDLCKEEGGG------------QVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2799

HSP 3 Score: 224.942 bits (572), Expect = 1.514e-57
Identity = 174/497 (35.01%), Postives = 259/497 (52.11%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSS---MANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVN 2026
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R    S   S   +   +E  ++  + R    +LR       R + DG    +  G+ S    P+   KN  TPV ++ + LG +L++W +K          KFI I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T + K+ATWVDET++ +                ++EH    +SEL+ E I  L    L +  +  + ++YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL N
Sbjct:  157 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPNLDKKN--TPV-QSPVSLGEDLQWWPDK-------DGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNA---------QNPSL---------------HHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVAS--------------KLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKN 584

HSP 4 Score: 154.066 bits (388), Expect = 4.297e-36
Identity = 126/390 (32.31%), Postives = 179/390 (45.90%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYD-GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                    +N  C     NS+ P++ DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS+  FLG+                  +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P       N T K   +      V ++ +E QTLM HILR D +     + N   AV  E +   +Q  IS + DG RNI+H  V++C P SN
Sbjct:  632 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS--------------------SNTNCQ----NSSGPDA-DPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLK---TGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQ----------------NERNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLIN-------LPA------NSTIKKKAA------VIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN 935

HSP 5 Score: 152.525 bits (384), Expect = 1.323e-35
Identity = 104/291 (35.74%), Postives = 143/291 (49.14%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRN-----------------TINNQNFCGRSNEGQ--LPLHM-----GFSSRWADRLLDNNIIFS-------GVPVGNLRT----------------RWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN                  +N QN   +  E Q  LP        G S+      L ++++         G P+ + R                 RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDLSL V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2022 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL 2309

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Human
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:HGNC Symbol;Acc:HGNC:16806])

HSP 1 Score: 140.969 bits (354), Expect = 2.656e-37
Identity = 70/125 (56.00%), Postives = 88/125 (70.40%), Query Frame = 2

Query: 8063 RWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDLSL V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct:   13 RWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL 134

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Celegans
Match: ubr-5 (UBR E3 ubiquitin ligase homolog [Source:UniProtKB/TrEMBL;Acc:G5EDT9])

HSP 1 Score: 238.039 bits (606), Expect = 5.632e-62
Identity = 128/324 (39.51%), Postives = 190/324 (58.64%), Query Frame = 2

Query: 10124 LFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            LF +  +  FY P+       N    R   YR+VGR++GI +   +  PL+  RH+  YIL LPI W D  F++  L+ +LR L K                   E + +F+IV +        S D K +   ++NL PNG++V V+ +NV +YV KY    ++       + I+ G+ DV+P+  L GL+PEDLRL++ G + +++ VL   T FLDES      SQE + +FK+WFWQV+ +F   ++Q L++FWT SPALPA+ + +    ++ +RP +D  LPTANTCISRLY+P+YS+K +LR KLL AI+ K+FGFV
Sbjct: 2657 LFEKAPYGEFYVPK-----IGNGAPMRLAAYRTVGRIMGICLSQGDIFPLRFSRHIFSYILKLPICWLDLGFYDPVLFNNLRALFKAHPS---------------ELDTDFSIVEQ--------SADGKAV---TVNLKPNGDEVLVNKDNVIEYVYKYAERVLVGKRIITFEAIREGILDVIPESMLFGLTPEDLRLIICGIESVSISVLQENTGFLDESRA----SQETLNRFKQWFWQVIESFTQQEKQELVFFWTGSPALPAAGK-WPTSASVMLRPQEDVFLPTANTCISRLYVPVYSSKRVLRTKLLLAIKAKNFGFV 2944

HSP 2 Score: 218.394 bits (555), Expect = 5.861e-56
Identity = 168/514 (32.68%), Postives = 233/514 (45.33%), Query Frame = 2

Query: 4085 GLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEK--CRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPL------TDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVF-VALQLQ-MAPDF------------------NRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVS--------LSELP-------RIAAD-IIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYS 5494
             LL  R+ +G TPF  +++QR Y  A  +   ++ L   Q +S      +  L  IFP      ++        +D+PL +LC ND CSFTWTG DHI QDI+EC+TCGLT SLCCC+ECA  CH+ HDC LK+TSPTAYCDCWEK  C CKALI G+   R+ LL +LL++T L   PN R EH++LFL +TV RQ RE    +    R+ T++  ++                           PE+ L P  FA  AL+    N                  N+V N    S   GIN        T  ++    QS S  LD+  F L  K       + + T    L+N  S P+   P     ++    R +RS+ RV  +A+ +  +AP                    +R R +       H   +  K  +  K   ++  FV+        L +LP        IAAD I  PVR G+L+P  N A      D +  L++ F S
Sbjct: 1129 ALLLTRDLNGMTPFQSAINQRAYGAATSIWRALLQL-GFQTMS-----EEQKLKYIFPSFNVDESHNA------DDSPLFILCYNDVCSFTWTGEDHINQDIYECKTCGLTGSLCCCSECALTCHRNHDCRLKRTSPTAYCDCWEKSSCNCKALIAGNELLREHLLSELLKYTRLFEYPNARNEHIMLFLARTVIRQTREQTYSQKRRSRYRTAMQTSQSSGT-----------------------PEHNLNPPKFAKTALEQCCKN-----------------ANVVMN----SIRCGINKFGQMELATPGQLHFVQQSTSTHLDKLTFALSNKILKDYSSLFVGT----LRNLLSAPIR-DPRVDQDIEMWVGRFVRSLVRVLTLAINVSPLAPSTILAAEDPTDNATPRDPREDRSRYNQATFQVFHALVISKK--ESSKLSEKSASFVAMITRIMQFLQQLPTFAVVQLAIAADAIFEPVRDGMLRPMVNPALAGNNHDPMDILEKYFTS 1579

HSP 3 Score: 132.109 bits (331), Expect = 6.642e-30
Identity = 134/474 (28.27%), Postives = 205/474 (43.25%), Query Frame = 2

Query:  635 IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEEN----GGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDIFPSIRLRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWK--------EKLKDNGKVK--DIK---FIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPF--KYRKSAMEKNR-DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRF 1996
            + A+ VPE+LI   Q VLQGKSR +IIRELQRT L+VN AVNNLLSRDD  E++    GG     +                 +LE  +  G+ G    +  S+  R + L  S+A+  E                       R    G     +G++ P  +  D  K +S    KNC+ LG ++E+W+        E  K +  VK  D K    I I     ++  +  +  ++ W W +SE     G     T+++N +                 H    ++   G  +I++S+ + R ++LT SG L +W+DE  A +          F+  +      V + SE     + +L TS  ++A R +S  I+W G++P     R +  EK   DR  K  V + G+    +     +      V G  V MK AP++ AG++   +    P IG LLED W   D CRF
Sbjct:  183 VPATNVPEELINNVQQVLQGKSRDVIIRELQRTGLNVNEAVNNLLSRDDGDEQDVLDVGGEHLIPEELLQ-------------ILEGGVPPGSSGAVA-MAESLLEREDRLLDSLASRAEM----------------------RYHFGGA----SGSKKPKANEKDKKKKDSETNWKNCIQLGEHVEWWRGAPGDGIPEHAKTDAPVKSEDDKANPVISITATSYQMYALHRNGKMYSWAWDESE-----GLDDPLTIVKNRD-----------------HPDHATIGTHGNPVIQMSSSNLRISILTRSGHLVSWLDECGAGV---------RFSLAS----ETVTKISEDSVMAVQDLVTSDHLAAFRIDS-IIHWCGIVPLVESTRSTKKEKEEADREKKKHVSF-GEAPVSSIPAVQSNSIEFFV-GQQVQMKKAPLYPAGSVAAQIDTSNPMIGVLLEDCWSATDHCRF 578

HSP 4 Score: 70.0922 bits (170), Expect = 4.074e-11
Identity = 52/169 (30.77%), Postives = 77/169 (45.56%), Query Frame = 2

Query: 7961 GQLPLHMGFSSRWADRLLDNNIIFSGVPVGNLRTRWRYSLELLSNSFEQ--------NVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCR--RDLSLIVNRERNLIICDTVTQLNTEYSRRNST-----NTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVL 8422
            G+ P ++G       +  DN +I S        ++W  +L  + N F          +V  E   +L     F  K+  F K  EK R Q    +++ L V RE   +  DT+ QL+  Y++R  +     +   PL   R +V F DEPGEG GV RSF T FAE+ +
Sbjct: 2288 GKFPGYIGRLDDSISKFKDNLLIHSCNRERLYFSKWFKTLNAIGNRFYDKMTEALGADVAFENSIMLRRLASFETKQRLFNKATEKYRTQHSNVKEIVLDVRREPGSLFRDTMVQLHHLYAKRMMSVRSLESGHAPLAGTRLRVHFIDEPGEGTGVTRSFYTAFAESCM 2456

[Close]

Query: 10124 LFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            LF +  +  FY P+       N    R   YR+VGR++GI +   +  PL+  RH+  YIL LPI W D  F++  L+ +LR L K                   E + +F+IV +        S D K +   ++NL PNG++V V+ +NV +YV KY    ++       + I+ G+ DV+P+  L GL+PEDLRL++ G + +++ VL   T FLDES      SQE + +FK+WFWQV+ +F   ++Q L++FWT SPALPA+ + +    ++ +RP +D  LPTANTCISRLY+P+YS+K +LR KLL AI+ K+FGFV
Sbjct: 2657 LFEKAPYGEFYVPK-----IGNGAPMRLAAYRTVGRIMGICLSQGDIFPLRFSRHIFSYILKLPICWLDLGFYDPVLFNNLRALFKAHPS---------------ELDTDFSIVEQ--------SADGKAV---TVNLKPNGDEVLVNKDNVIEYVYKYAERVLVGKRIITFEAIREGILDVIPESMLFGLTPEDLRLIICGIESVSISVLQENTGFLDESRA----SQETLNRFKQWFWQVIESFTQQEKQELVFFWTGSPALPAAGK-WPTSASVMLRPQEDVFLPTANTCISRLYVPVYSSKRVLRTKLLLAIKAKNFGFV 2944

HSP 2 Score: 218.394 bits (555), Expect = 5.861e-56
Identity = 168/514 (32.68%), Postives = 233/514 (45.33%), Query Frame = 2

Query: 4085 GLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEK--CRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPL------TDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVF-VALQLQ-MAPDF------------------NRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVS--------LSELP-------RIAAD-IIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYS 5494
             LL  R+ +G TPF  +++QR Y  A  +   ++ L   Q +S      +  L  IFP      ++        +D+PL +LC ND CSFTWTG DHI QDI+EC+TCGLT SLCCC+ECA  CH+ HDC LK+TSPTAYCDCWEK  C CKALI G+   R+ LL +LL++T L   PN R EH++LFL +TV RQ RE    +    R+ T++  ++                           PE+ L P  FA  AL+    N                  N+V N    S   GIN        T  ++    QS S  LD+  F L  K       + + T    L+N  S P+   P     ++    R +RS+ RV  +A+ +  +AP                    +R R +       H   +  K  +  K   ++  FV+        L +LP        IAAD I  PVR G+L+P  N A      D +  L++ F S
Sbjct: 1129 ALLLTRDLNGMTPFQSAINQRAYGAATSIWRALLQL-GFQTMS-----EEQKLKYIFPSFNVDESHNA------DDSPLFILCYNDVCSFTWTGEDHINQDIYECKTCGLTGSLCCCSECALTCHRNHDCRLKRTSPTAYCDCWEKSSCNCKALIAGNELLREHLLSELLKYTRLFEYPNARNEHIMLFLARTVIRQTREQTYSQKRRSRYRTAMQTSQSSGT-----------------------PEHNLNPPKFAKTALEQCCKN-----------------ANVVMN----SIRCGINKFGQMELATPGQLHFVQQSTSTHLDKLTFALSNKILKDYSSLFVGT----LRNLLSAPIR-DPRVDQDIEMWVGRFVRSLVRVLTLAINVSPLAPSTILAAEDPTDNATPRDPREDRSRYNQATFQVFHALVISKK--ESSKLSEKSASFVAMITRIMQFLQQLPTFAVVQLAIAADAIFEPVRDGMLRPMVNPALAGNNHDPMDILEKYFTS 1579

HSP 3 Score: 132.109 bits (331), Expect = 6.642e-30
Identity = 134/474 (28.27%), Postives = 205/474 (43.25%), Query Frame = 2

Query:  635 IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEEN----GGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDIFPSIRLRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWK--------EKLKDNGKVK--DIK---FIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPF--KYRKSAMEKNR-DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRF 1996
            + A+ VPE+LI   Q VLQGKSR +IIRELQRT L+VN AVNNLLSRDD  E++    GG     +                 +LE  +  G+ G    +  S+  R + L  S+A+  E                       R    G     +G++ P  +  D  K +S    KNC+ LG ++E+W+        E  K +  VK  D K    I I     ++  +  +  ++ W W +SE     G     T+++N +                 H    ++   G  +I++S+ + R ++LT SG L +W+DE  A +          F+  +      V + SE     + +L TS  ++A R +S  I+W G++P     R +  EK   DR  K  V + G+    +     +      V G  V MK AP++ AG++   +    P IG LLED W   D CRF
Sbjct:  183 VPATNVPEELINNVQQVLQGKSRDVIIRELQRTGLNVNEAVNNLLSRDDGDEQDVLDVGGEHLIPEELLQ-------------ILEGGVPPGSSGAVA-MAESLLEREDRLLDSLASRAEM----------------------RYHFGGA----SGSKKPKANEKDKKKKDSETNWKNCIQLGEHVEWWRGAPGDGIPEHAKTDAPVKSEDDKANPVISITATSYQMYALHRNGKMYSWAWDESE-----GLDDPLTIVKNRD-----------------HPDHATIGTHGNPVIQMSSSNLRISILTRSGHLVSWLDECGAGV---------RFSLAS----ETVTKISEDSVMAVQDLVTSDHLAAFRIDS-IIHWCGIVPLVESTRSTKKEKEEADREKKKHVSF-GEAPVSSIPAVQSNSIEFFV-GQQVQMKKAPLYPAGSVAAQIDTSNPMIGVLLEDCWSATDHCRF 578

HSP 4 Score: 70.0922 bits (170), Expect = 4.074e-11
Identity = 52/169 (30.77%), Postives = 77/169 (45.56%), Query Frame = 2

Query: 7961 GQLPLHMGFSSRWADRLLDNNIIFSGVPVGNLRTRWRYSLELLSNSFEQ--------NVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCR--RDLSLIVNRERNLIICDTVTQLNTEYSRRNST-----NTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVL 8422
            G+ P ++G       +  DN +I S        ++W  +L  + N F          +V  E   +L     F  K+  F K  EK R Q    +++ L V RE   +  DT+ QL+  Y++R  +     +   PL   R +V F DEPGEG GV RSF T FAE+ +
Sbjct: 2288 GKFPGYIGRLDDSISKFKDNLLIHSCNRERLYFSKWFKTLNAIGNRFYDKMTEALGADVAFENSIMLRRLASFETKQRLFNKATEKYRTQHSNVKEIVLDVRREPGSLFRDTMVQLHHLYAKRMMSVRSLESGHAPLAGTRLRVHFIDEPGEGTGVTRSFYTAFAESCM 2456

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Celegans
Match: eel-1 (Enhancer of EfL-1 mutant phenotype [Source:UniProtKB/TrEMBL;Acc:U4PBK1])

HSP 1 Score: 110.153 bits (274), Expect = 3.396e-23
Identity = 78/307 (25.41%), Postives = 144/307 (46.91%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITI----RPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIE--TKSFGFV 11095
            + ++ VGR+I  S+  ++ +     R   K+IL LP+ + D    +   ++SL  L+               ++P+ +  L+ T     EE            G+ S+ +L PNG  ++V+  N  +YVK  C  +M   ++ QLD    G Y+++PK  ++  + ++L LL++G   ++++ + + T +            +K +   +WFW+ + +F    +   L F T +  +P    AS +G   +   +I    R  D   LP A+TC ++L +P Y +   LR+ LL AI   T+ FGF 
Sbjct: 3911 DYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLL---------------QNPIDDLALDLTFSTEVEE-----------FGVRSVRDLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDY---------KGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGD--RLPAAHTCFNQLDLPQYESYEKLRQSLLLAIRECTEGFGFA 4180

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Celegans
Match: eel-1 (Enhancer of EfL-1 mutant phenotype [Source:UniProtKB/TrEMBL;Acc:U4PBK1])

HSP 1 Score: 110.153 bits (274), Expect = 3.482e-23
Identity = 78/307 (25.41%), Postives = 144/307 (46.91%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITI----RPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIE--TKSFGFV 11095
            + ++ VGR+I  S+  ++ +     R   K+IL LP+ + D    +   ++SL  L+               ++P+ +  L+ T     EE            G+ S+ +L PNG  ++V+  N  +YVK  C  +M   ++ QLD    G Y+++PK  ++  + ++L LL++G   ++++ + + T +            +K +   +WFW+ + +F    +   L F T +  +P    AS +G   +   +I    R  D   LP A+TC ++L +P Y +   LR+ LL AI   T+ FGF 
Sbjct: 3908 DYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLL---------------QNPIDDLALDLTFSTEVEE-----------FGVRSVRDLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDY---------KGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGD--RLPAAHTCFNQLDLPQYESYEKLRQSLLLAIRECTEGFGFA 4177

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Celegans
Match: eel-1 (Enhancer of EfL-1 mutant phenotype [Source:UniProtKB/TrEMBL;Acc:U4PBK1])

HSP 1 Score: 110.153 bits (274), Expect = 3.601e-23
Identity = 78/307 (25.41%), Postives = 144/307 (46.91%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITI----RPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIE--TKSFGFV 11095
            + ++ VGR+I  S+  ++ +     R   K+IL LP+ + D    +   ++SL  L+               ++P+ +  L+ T     EE            G+ S+ +L PNG  ++V+  N  +YVK  C  +M   ++ QLD    G Y+++PK  ++  + ++L LL++G   ++++ + + T +            +K +   +WFW+ + +F    +   L F T +  +P    AS +G   +   +I    R  D   LP A+TC ++L +P Y +   LR+ LL AI   T+ FGF 
Sbjct: 3911 DYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLL---------------QNPIDDLALDLTFSTEVEE-----------FGVRSVRDLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDY---------KGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGD--RLPAAHTCFNQLDLPQYESYEKLRQSLLLAIRECTEGFGFA 4180

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Fly
Match: hyd (gene:FBgn0002431 transcript:FBtr0082090)

HSP 1 Score: 329.717 bits (844), Expect = 1.160e-89
Identity = 167/325 (51.38%), Postives = 222/325 (68.31%), Query Frame = 2

Query: 10121 PLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            PLF+ PG  GFY PR+         + R N +R++GR+IG+ +L NE +PL L RHVLKYILG  I +HD AFF+  LYES RQ+++ A+  +        E+ +    L F I   +EEG     G+R+        LIP G DV V S+N+F+YV++Y   R+I   +  L+ +K+GV+DVLP +++  L+ EDLRLLLNG  +INV  LISYT+F DESS       +K+ KFKKWFW +V   N ++RQ+L+YFWT SPALPAS +GFQP+P++TIRPADD HLPTANTCISRLYIPLYS+K ILR K+L AI++K+FGFV
Sbjct: 2589 PLFYSPGKRGFYTPRQ-----GFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKE-------GEETINRMELCFVIDLMKEEG----CGNRE--------LIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESS----EGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2885

HSP 2 Score: 324.324 bits (830), Expect = 5.337e-88
Identity = 198/501 (39.52%), Postives = 278/501 (55.49%), Query Frame = 2

Query: 3989 PPIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGR-RHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P    D  ++R ++  I+  +   P +  +L  +LS ++A GQTPFM SVS R Y   + LL+ I+ L +           QL  +MIFP                + +PL V+C ND CSFTWTG DHI Q+IFEC+TCGLT SLCCCTECARVCHKGHDC LK+T+PTAYCDCWEKC+CKALI G+ + R  LL KL+  TDL T  N + E +LLFL++TV RQ  E +Q R S R R+ ++      GNN      S +S  +      +  MP++ LEP  FA  AL+ +L +W +V ++++SG     V N   +   +S ++G N      +F+  Q  S  LD+F  +LI K  S  +D LL TL +ELQN      +       + +    R +RSVARVFV   L+  P+   KR+S+   N         K +  C ++F+ L  +S+ EL  ++  +IAPVR G+++PT   A F   S  + N D +F
Sbjct: 1119 PTYTFDLAQRREHALTILQQMCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQD--------PQLKEAMIFPNGSPA-----------DQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNN------SVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFN------MFIQTQHGSTLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRS------KEAEEVVRRFVRSVARVFVIFNLEKQPN-PEKRKSHSSCN---------KYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPT---APFTMSSSNLDNSDDLF 1569

HSP 3 Score: 144.05 bits (362), Expect = 2.126e-33
Identity = 86/295 (29.15%), Postives = 138/295 (46.78%), Query Frame = 2

Query: 1118 DCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSV 2002
            D  K E +P+  + + +   L+ W EK         ++F  I  +YSE I ++   DL+QWRW D+EP+ S          +  N+               YH +  SLN+  E++  +SA   R +V+T + ++ATW+DE +  I                ++EH    F+E   ++I +++  +L + V+  S NIYWWGV+PF  R+   +K R +T K                       +I  G+ V MK  P++ +G+IGFT   GVPK+G LL   W   D+CR  +
Sbjct:  333 DSKKKEPSPML-SPIWISEELQPWPEK-------SSVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYKS----------ETENV---------------YHPKTVSLNIV-ERVELISANFIRCSVVTETNRVATWMDEQLGYI--------------GAKLEHSCCAFNEFISDSITKIYVCSLYTVVKTESNNIYWWGVLPFDQRRFLWDKFRTKTKKP----------------FKVVATDINVGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDVCRMKI 563

HSP 4 Score: 117.087 bits (292), Expect = 3.180e-25
Identity = 64/134 (47.76%), Postives = 86/134 (64.18%), Query Frame = 2

Query: 8030 FSGVPVGN-LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLI-VNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLS 8425
            FS +P  N L +RW+ +L+L    F  +VG+E GSVL +   F +KE RFR+ MEKLRN  +RDL L  + R R  +I  T  +LNT++  + S   Q P+  +R KV F DEPGEG+GVARSF T  AEA+L+
Sbjct: 2278 FSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQ-SRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLA 2410

HSP 5 Score: 114.775 bits (286), Expect = 1.820e-24
Identity = 117/405 (28.89%), Postives = 180/405 (44.44%), Query Frame = 2

Query: 2483 TDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVET 3694
            +D   +  HKR      K + +   PQ +  ++EE W +KDV+F+ED +  PVG VLKVDG   AV+F         A+N      AA   ++ +  + TS      +      W   CRLLR+E++ + +  + +R PD +QK PK I   V  +A          IL +AV++  IH++  K    K I Y L +L   K   +    T  N F+G  P   L+A   +             +     I LRDGNG +YPL      + + + S    I  P W DLPPV+ +    +++        ++ G N  S             ++ +  L+ ++Q LM HILR D K     +       + D  +  ++ E+ DG RNI H  V MC P SN ++
Sbjct:  635 SDTGSVTSHKRTKRATTKEDSNA--PQ-EGRKDEELWEVKDVVFVED-KVGPVGKVLKVDGDFVAVRF--------PAINAAAVAAAAAATSSTSNTASTSKEEGKEDD-----W-QQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKI--NVGGDAAGAQ------ILTLAVDSRGIHVI--KKVLGK-IHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDC------------SGNSSTIVLRDGNGALYPL------AKDCLGS----IKDPQWFDLPPVKSITMSTISL------PAMLSGVNLKS-------------KVCMTALLFDTQKLMPHILRCDVKNSFAALGRLEREDQADTAL--VVEERCDGARNIFHACVIMCAPSSNKDS 967

HSP 6 Score: 75.0998 bits (183), Expect = 1.803e-12
Identity = 36/47 (76.60%), Postives = 41/47 (87.23%), Query Frame = 2

Query:  635 IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSR 775
            + A+ VPE+LI Q + VLQGKSR LIIRELQRTNLDVN+AVNNLLSR
Sbjct:  150 VPATYVPEELISQAEVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSR 196

HSP 7 Score: 70.4774 bits (171), Expect = 4.325e-11
Identity = 97/413 (23.49%), Postives = 151/413 (36.56%), Query Frame = 2

Query: 6896 LARAFCCLIKLLAGLLNQMYYSREKNESVNQKEYDRFGLNLGQDNEYSSSCSPGATLSQSEEEHVMIES--SQQLGPIWIWICQSMDFLESQVCFANAFQR--------------KHGTYKARPVP-TFEQVNTPNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLXXXXXXXXXXXLNSLRPTIGSECGDSILDEDTNCPTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQ-------LPLHMGFSSRWADRLLDNNIIFSGVPVGNLRT 8062
            LARAF   I+ ++ L++ + Y                  N+  D E S        L    +E + +++   ++L   W W+   MD  E+Q+ F                       +    P P T   VN  NI      G  +R DF  Y +S+MR+ + EH D  P  L+     H+AY++DA +Y MR   G   DK             +D ++                       +N+L P   S   D   DE  N      + Q + SS+       RR           +FF R++          + F+ P+  ++PLA  P LLQP     E+F  L           N N  G +N+G         P  +GFS    + L  N  ++  VP+ + +T
Sbjct: 1806 LARAFGITIRQISELISILSY------------------NVLNDIETS--------LKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIM-----GSNSRRDFFTYCLSLMRSHTSEHRDALPV-LDITALRHIAYVLDAFVYYMRNDSGFY-DK-------------QDTISG---------------------RINNLSPMTESYDTD---DELANLEEFNADVQMSASSMPSGSQGTRR----------HAFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLL-----VTTNANNSGATNDGDGGSIFDYTPTRLGFS----NSLKRNERVYETVPIDSSKT 2129

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Fly
Match: hyd (gene:FBgn0002431 transcript:FBtr0339599)

HSP 1 Score: 329.331 bits (843), Expect = 1.470e-89
Identity = 167/325 (51.38%), Postives = 222/325 (68.31%), Query Frame = 2

Query: 10121 PLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            PLF+ PG  GFY PR+         + R N +R++GR+IG+ +L NE +PL L RHVLKYILG  I +HD AFF+  LYES RQ+++ A+  +        E+ +    L F I   +EEG     G+R+        LIP G DV V S+N+F+YV++Y   R+I   +  L+ +K+GV+DVLP +++  L+ EDLRLLLNG  +INV  LISYT+F DESS       +K+ KFKKWFW +V   N ++RQ+L+YFWT SPALPAS +GFQP+P++TIRPADD HLPTANTCISRLYIPLYS+K ILR K+L AI++K+FGFV
Sbjct: 2591 PLFYSPGKRGFYTPRQ-----GFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKE-------GEETINRMELCFVIDLMKEEG----CGNRE--------LIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESS----EGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2887

HSP 2 Score: 326.635 bits (836), Expect = 9.679e-89
Identity = 199/501 (39.72%), Postives = 279/501 (55.69%), Query Frame = 2

Query: 3989 PPIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGR-RHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P    D  ++R ++  I+  +   P +  +L  +LS ++A GQTPFM SVS R Y   + LL+ I+ L +           QL  +MIFP                + +PL V+C ND CSFTWTG DHI Q+IFEC+TCGLT SLCCCTECARVCHKGHDC LK+T+PTAYCDCWEKC+CKALI G+ + R  LL KL+  TDL T  N + E +LLFL++TV RQ  E +Q R S R R+ ++      GNN      S +S  +      +  MP++ LEP  FA  AL+ +L +W +V ++++SG     V N   +   +S ++G N      +F+  Q  S  LD+F  +LI K  S  +D LL TL +ELQN      +       + +    R +RSVARVFV   L+  P+   KR+S+   N         K +  C ++F+ L  +S+ EL  ++  +IAPVR G+++PTA +       D VRN D +F
Sbjct: 1119 PTYTFDLAQRREHALTILQQMCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQD--------PQLKEAMIFPNGSPA-----------DQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNN------SVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFN------MFIQTQHGSTLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRS------KEAEEVVRRFVRSVARVFVIFNLEKQPN-PEKRKSHSSCN---------KYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLD-VRNSDDLF 1571

HSP 3 Score: 144.05 bits (362), Expect = 2.144e-33
Identity = 86/295 (29.15%), Postives = 138/295 (46.78%), Query Frame = 2

Query: 1118 DCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSV 2002
            D  K E +P+  + + +   L+ W EK         ++F  I  +YSE I ++   DL+QWRW D+EP+ S          +  N+               YH +  SLN+  E++  +SA   R +V+T + ++ATW+DE +  I                ++EH    F+E   ++I +++  +L + V+  S NIYWWGV+PF  R+   +K R +T K                       +I  G+ V MK  P++ +G+IGFT   GVPK+G LL   W   D+CR  +
Sbjct:  333 DSKKKEPSPML-SPIWISEELQPWPEK-------SSVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYKS----------ETENV---------------YHPKTVSLNIV-ERVELISANFIRCSVVTETNRVATWMDEQLGYI--------------GAKLEHSCCAFNEFISDSITKIYVCSLYTVVKTESNNIYWWGVLPFDQRRFLWDKFRTKTKKP----------------FKVVATDINVGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDVCRMKI 563

HSP 4 Score: 117.087 bits (292), Expect = 3.180e-25
Identity = 64/134 (47.76%), Postives = 86/134 (64.18%), Query Frame = 2

Query: 8030 FSGVPVGN-LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLI-VNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLS 8425
            FS +P  N L +RW+ +L+L    F  +VG+E GSVL +   F +KE RFR+ MEKLRN  +RDL L  + R R  +I  T  +LNT++  + S   Q P+  +R KV F DEPGEG+GVARSF T  AEA+L+
Sbjct: 2280 FSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQ-SRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLA 2412

HSP 5 Score: 114.775 bits (286), Expect = 1.820e-24
Identity = 117/405 (28.89%), Postives = 180/405 (44.44%), Query Frame = 2

Query: 2483 TDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVET 3694
            +D   +  HKR      K + +   PQ +  ++EE W +KDV+F+ED +  PVG VLKVDG   AV+F         A+N      AA   ++ +  + TS      +      W   CRLLR+E++ + +  + +R PD +QK PK I   V  +A          IL +AV++  IH++  K    K I Y L +L   K   +    T  N F+G  P   L+A   +             +     I LRDGNG +YPL      + + + S    I  P W DLPPV+ +    +++        ++ G N  S             ++ +  L+ ++Q LM HILR D K     +       + D  +  ++ E+ DG RNI H  V MC P SN ++
Sbjct:  635 SDTGSVTSHKRTKRATTKEDSNA--PQ-EGRKDEELWEVKDVVFVED-KVGPVGKVLKVDGDFVAVRF--------PAINAAAVAAAAAATSSTSNTASTSKEEGKEDD-----W-QQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKI--NVGGDAAGAQ------ILTLAVDSRGIHVI--KKVLGK-IHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDC------------SGNSSTIVLRDGNGALYPL------AKDCLGS----IKDPQWFDLPPVKSITMSTISL------PAMLSGVNLKS-------------KVCMTALLFDTQKLMPHILRCDVKNSFAALGRLEREDQADTAL--VVEERCDGARNIFHACVIMCAPSSNKDS 967

HSP 6 Score: 75.0998 bits (183), Expect = 1.803e-12
Identity = 36/47 (76.60%), Postives = 41/47 (87.23%), Query Frame = 2

Query:  635 IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSR 775
            + A+ VPE+LI Q + VLQGKSR LIIRELQRTNLDVN+AVNNLLSR
Sbjct:  150 VPATYVPEELISQAEVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSR 196

HSP 7 Score: 70.4774 bits (171), Expect = 4.473e-11
Identity = 97/413 (23.49%), Postives = 151/413 (36.56%), Query Frame = 2

Query: 6896 LARAFCCLIKLLAGLLNQMYYSREKNESVNQKEYDRFGLNLGQDNEYSSSCSPGATLSQSEEEHVMIES--SQQLGPIWIWICQSMDFLESQVCFANAFQR--------------KHGTYKARPVP-TFEQVNTPNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLXXXXXXXXXXXLNSLRPTIGSECGDSILDEDTNCPTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQ-------LPLHMGFSSRWADRLLDNNIIFSGVPVGNLRT 8062
            LARAF   I+ ++ L++ + Y                  N+  D E S        L    +E + +++   ++L   W W+   MD  E+Q+ F                       +    P P T   VN  NI      G  +R DF  Y +S+MR+ + EH D  P  L+     H+AY++DA +Y MR   G   DK             +D ++                       +N+L P   S   D   DE  N      + Q + SS+       RR           +FF R++          + F+ P+  ++PLA  P LLQP     E+F  L           N N  G +N+G         P  +GFS    + L  N  ++  VP+ + +T
Sbjct: 1808 LARAFGITIRQISELISILSY------------------NVLNDIETS--------LKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIM-----GSNSRRDFFTYCLSLMRSHTSEHRDALPV-LDITALRHIAYVLDAFVYYMRNDSGFY-DK-------------QDTISG---------------------RINNLSPMTESYDTD---DELANLEEFNADVQMSASSMPSGSQGTRR----------HAFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLL-----VTTNANNSGATNDGDGGSIFDYTPTRLGFS----NSLKRNERVYETVPIDSSKT 2131

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Fly
Match: HUWE1 (gene:FBgn0030674 transcript:FBtr0340304)

HSP 1 Score: 115.546 bits (288), Expect = 9.617e-25
Identity = 84/300 (28.00%), Postives = 138/300 (46.00%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITIRPADDF--HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            ++ VGRVI  ++  N+ +     R   K+ILG  +   D    + + Y+ L  LMK   +   +G           Y L F+   +E              G+  I +L PNG D  V   N F+YV+  C  +M   ++ QLD    G YD++PKH ++  + ++L LL++G  +I++E L + T +   +S +            +WFW+ + +F+   R   L F T +  +P     S +G   +    I   D     LP A+TC ++L +P+Y +   LR  LL+AI   S GF
Sbjct: 4884 FKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMK--NDISTLG-----------YELTFSTEVQE-------------FGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQ---------IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Fly
Match: HUWE1 (gene:FBgn0030674 transcript:FBtr0339688)

HSP 1 Score: 115.546 bits (288), Expect = 9.937e-25
Identity = 84/300 (28.00%), Postives = 138/300 (46.00%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITIRPADDF--HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            ++ VGRVI  ++  N+ +     R   K+ILG  +   D    + + Y+ L  LMK   +   +G           Y L F+   +E              G+  I +L PNG D  V   N F+YV+  C  +M   ++ QLD    G YD++PKH ++  + ++L LL++G  +I++E L + T +   +S +            +WFW+ + +F+   R   L F T +  +P     S +G   +    I   D     LP A+TC ++L +P+Y +   LR  LL+AI   S GF
Sbjct: 4849 FKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMK--NDISTLG-----------YELTFSTEVQE-------------FGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQ---------IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5113

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Fly
Match: HUWE1 (gene:FBgn0030674 transcript:FBtr0339686)

HSP 1 Score: 115.546 bits (288), Expect = 1.003e-24
Identity = 84/300 (28.00%), Postives = 138/300 (46.00%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITIRPADDF--HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            ++ VGRVI  ++  N+ +     R   K+ILG  +   D    + + Y+ L  LMK   +   +G           Y L F+   +E              G+  I +L PNG D  V   N F+YV+  C  +M   ++ QLD    G YD++PKH ++  + ++L LL++G  +I++E L + T +   +S +            +WFW+ + +F+   R   L F T +  +P     S +G   +    I   D     LP A+TC ++L +P+Y +   LR  LL+AI   S GF
Sbjct: 4878 FKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMK--NDISTLG-----------YELTFSTEVQE-------------FGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQ---------IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5142

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Zebrafish
Match: ubr5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:ZFIN;Acc:ZDB-GENE-030131-6559])

HSP 1 Score: 327.02 bits (837), Expect = 1.108e-88
Identity = 202/504 (40.08%), Postives = 292/504 (57.94%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLA---LSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTAS--SSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   +  HL  LLS ++A G TPFM +VS R YP A+ +L+    +   +    L  K   A   + MI P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  +AR +LL +LL  T+L T PN R EH+LLFLV+TV RQ  EH Q R             R   + N  A+S          A +  MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++++LN QS + +LD F   LI K A   + +D LL TL KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  C+R+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DAV+  +++F
Sbjct: 1074 PSVVESKDRKANAHLILKLMCDSIVLRPHLRELLSAKDARGMTPFMLAVSGRAYPAAITVLEAAQKIAKGE--PGLGEKEDTASVFMEMICPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKAARLDLLYRLLTTTNLVTTPNSRGEHILLFLVQTVARQSVEHCQYRP-----------PRIREDRNRKAAS----------AEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIAHLLP--EEQMYLNQQSGTIRLDCFTHCLIVKCAPDITFIDTLLGTLVKELQNKYT------PGRREEAINVTRRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCRRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAVQGSEELF 1517

HSP 2 Score: 315.464 bits (807), Expect = 3.289e-85
Identity = 156/326 (47.85%), Postives = 217/326 (66.56%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL++ ++  +   +  A        +L F I   +EEG               + L+  G ++ V   NV++YV++Y   RM+ + +  L  ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2498 APLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLIRHSQTEEAEAVFAA-------MDLAFAIDLCKEEGAG------------QVELLSGGVNMPVTPLNVYEYVRRYAEHRMLVVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2795

HSP 3 Score: 240.35 bits (612), Expect = 2.257e-62
Identity = 209/650 (32.15%), Postives = 316/650 (48.62%), Query Frame = 2

Query:  122 ELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLXXXXXXXXXXXXXXXXXXENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSS---MANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRN 2038
            +L +RL+E SE++ +        L  L Q  +++ VVG N   F L+DGR+CR +F       +Q       +   +   K+     A  SSR   T+      S + +  R   N+ G    +           +  +  +++  S  +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R    S   S   +   +E  ++  + R    +LR       R + DG    +  G+ S    P      +S P+ ++ + LG  L++W +      K    KF+ I  +YSEL+ ++T  +L+QW+W + EP+ +          QN +I               +H R+P L L  EKI  LSA S RATV T + K+ATWVDET+              +T   ++EH    F EL+ E I  L    L +  +  + ++YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F+V  G+PK+G LLE  W + D CRF +R  +SL N  +N
Sbjct:   17 QLNDRLREVSEKLNKYNCNSHPHLIPLEQAKLKQCVVGPNHAGFLLEDGRICRISFA------VQPDRLELGKPDGNDGSKLSSVSGAGRSSRPGRTSDPPWFLSGSDTLGRLAGNTLGTRWSSGVNGGG---GGSSGRSSTAARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDAERGSTSREGEPS--LDKKSVPL-QSPVTLGEELQWWPD------KDYVTKFVSIGALYSELVAVSTKGELYQWKWNEPEPYRNA---------QNPSI---------------HHPRVPFLGLTNEKITHLSANSIRATVATENNKVATWVDETL--------------STVAAKLEHGAQTFPELQGERIVSLHCCALYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISS--------------IPNITVGTQVCLRNNPLYHAGAVAFSVNAGIPKVGVLLESVWNMNDSCRFQLRSPESLKNMEKN 589

HSP 4 Score: 143.28 bits (360), Expect = 5.900e-33
Identity = 116/389 (29.82%), Postives = 174/389 (44.73%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNV---MDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF                             S  S  S  P   DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++  +  +   +  L+ GK    +H   TS   FLG++                 +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P   SNST            +  + ++ +E QTLM H+LR D +        ++   +  +    +  ++  + DG RN++H  V++C P+SN
Sbjct:  633 KRRRSTPAPKEEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKF-------------------------PGTSSSVSSQSAAPTDSDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKA-------------EILAVNVDSKGVHAVLKTGSWVRYCVFD-LATGKAEQENH-FPTSNLAFLGQSE----------------RNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPIASLGMGVHSLAN-------LP---SNSTIK---------KKAAIIIMAVEKQTLMQHVLRCDYEACRQYLISLEQAMLLEQNPHALDTLLGHRCDGNRNVLHACVSVCFPVSN 936

HSP 5 Score: 135.191 bits (339), Expect = 1.289e-30
Identity = 69/138 (50.00%), Postives = 91/138 (65.94%), Query Frame = 2

Query: 8030 FSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRN   RDL+L V+R+R  +I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS + L
Sbjct: 2178 FMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNLQSRDLALEVDRDREQLIQQTMRQLNAHFGRRCTT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNDKL 2312

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Zebrafish
Match: hace1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:572430])

HSP 1 Score: 98.2117 bits (243), Expect = 1.235e-19
Identity = 79/306 (25.82%), Postives = 138/306 (45.10%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIG-MNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINV---EVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP-------ASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            N +R  G+++G+++   + + +   R   K+ILG+P+ + D +  + +  ++L+ ++               ++ + +  L  T            S +  V G M  + L P G  + V  +N  +YV+     RM   ++PQ++    G +  +P   +      +L LLL+G  EI+V   +    YTS  D         QE V    +WFW+VV      +R  LL F T S  +P           G Q   T+   P     LPT++TCI+ L +P Y +K +LR++LL A+   S+G+
Sbjct:  635 NYFRFAGQILGLALYHRQLVNIYFTRSFYKHILGIPVSYQDVSSIDPEYAKNLQWIL---------------DNDISDLGLELTF-----------SVETDVFGTMEEVPLKPGGTTIQVTQDNKEEYVQLVTELRMTRAIQPQINAFLQGFHTFIPPSLIQLFDEYELELLLSGMPEIDVMDWKRNTEYTSGYD--------LQEPVI---QWFWEVVENLTQEERVLLLQFVTGSSRVPHGGFAFLMGGSGLQKF-TVAAVPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLLVALHCGSYGY 902

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Zebrafish
Match: smurf2 (SMAD specific E3 ubiquitin protein ligase 2 [Source:NCBI gene;Acc:563633])

HSP 1 Score: 87.8113 bits (216), Expect = 1.786e-16
Identity = 77/302 (25.50%), Postives = 132/302 (43.71%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMP--------TITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            +  VGR++G+++     +         K +LG PI   D    +  L+ SL  ++    +  + G+        +E+N    I+  E                    L PNG+ + V  +   +YV+ Y   R +  ++ Q   ++ G  +V+P+H L     ++L L++ G  +I++    S T       CT        +   KWFW+ V +++  +R  LL F T S  +P   QGF+ +         TI    A   +LP A+TC +R+ IP Y +   L +KLL AIE ++ GF 
Sbjct:  500 FHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWIL----DNDITGVLD--HTFCVEHNAYGEIIQHE--------------------LKPNGKSIPVTQDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDINDWKSNTRL---KHCTPD------SNIVKWFWRAVESYDEERRARLLQFVTGSSRVPL--QGFKALQGAAGPRLFTIHQIDASTNNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIE-ETCGFA 763

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Zebrafish
Match: hecw2a (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a [Source:ZFIN;Acc:ZDB-GENE-090311-22])

HSP 1 Score: 87.4261 bits (215), Expect = 4.092e-16
Identity = 79/313 (25.24%), Postives = 133/313 (42.49%), Query Frame = 2

Query: 10181 DNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVL---ISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQ-PMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAI-ETKSFGF 11092
            DN+ E+     +R  GR++G++++    +     R   K +L +P    D  F + + ++SL Q MK               D  +E  L+ T    EE  G           +    L P G  + V   N  +Y+++    R+   V  Q + +  G Y+V+    ++     +L L++ GT EI++        Y     ++   I           +WFW  V  FN+ QR  LL F T + ++P    AS +G   P      +      LP A+TC +RL +P Y +  +L EK++ A+ ET +FG 
Sbjct: 1204 DNHHEW-----FRFSGRILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSL-QWMK---------------DNDIEDMLDLTFTVNEEVFGQ----------ITERELKPGGSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVI-----------RWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSMLYEKMVTAVEETSTFGL 1474

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Zebrafish
Match: hecw2a (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a [Source:ZFIN;Acc:ZDB-GENE-090311-22])

HSP 1 Score: 87.0409 bits (214), Expect = 4.096e-16
Identity = 79/313 (25.24%), Postives = 133/313 (42.49%), Query Frame = 2

Query: 10181 DNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVL---ISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQ-PMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAI-ETKSFGF 11092
            DN+ E+     +R  GR++G++++    +     R   K +L +P    D  F + + ++SL Q MK               D  +E  L+ T    EE  G           +    L P G  + V   N  +Y+++    R+   V  Q + +  G Y+V+    ++     +L L++ GT EI++        Y     ++   I           +WFW  V  FN+ QR  LL F T + ++P    AS +G   P      +      LP A+TC +RL +P Y +  +L EK++ A+ ET +FG 
Sbjct: 1140 DNHHEW-----FRFSGRILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSL-QWMK---------------DNDIEDMLDLTFTVNEEVFGQ----------ITERELKPGGSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVI-----------RWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSMLYEKMVTAVEETSTFGL 1410

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Xenopus
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:NCBI gene;Acc:100490232])

HSP 1 Score: 329.331 bits (843), Expect = 2.993e-89
Identity = 200/504 (39.68%), Postives = 288/504 (57.14%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   +  S    +  +   MI PP  +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L T+PN R EHLLLFLV+TV RQ  EH Q R    R        R+    N   S                MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1062 PSVVESKDRKANAHFILKLLCDSIVLQPYLRDLLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEANSS-EKEEDVFKGMICPPGTNA-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTITNLVTMPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE------DRNRKAANPEDSD---------------MPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAVAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1503

HSP 2 Score: 322.398 bits (825), Expect = 3.540e-87
Identity = 160/329 (48.63%), Postives = 220/329 (66.87%), Query Frame = 2

Query: 10112 EQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTI-VPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            +  PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L R V+K +LG  + WHDFAFF+  +YESLRQL+  ++      +           +L F I + +EE GG              + LIPNG ++ V   NV++YV+KY   RM+T+ +  L+ ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2485 DNAPLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLSRQVIKVLLGRKVNWHDFAFFDHVMYESLRQLILASQSPDADAV-------FASMDLAFAIDLCKEESGGQ-------------VELIPNGVNIPVTPQNVYEYVRKYAEHRMLTVAEQPLNAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2784

HSP 3 Score: 231.491 bits (589), Expect = 1.541e-59
Identity = 175/497 (35.21%), Postives = 257/497 (51.71%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIR---LRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVN 2026
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R   L R      +   +E  ++  + R    +LR       R + DG    +  G+ S    P    KN  TP+ ++ + LG +L++W EK          KFI I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T S K+ATWVDET++ +                ++EH    F EL+ + I  L    L +  +  + N+YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL N
Sbjct:  147 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRIGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPALDKKN--TPI-QSPVSLGEDLQWWPEK-------DGTKFISIGALYSELVAVSSKGELYQWKWMESEPYRNT---------QNLSL---------------HHPRASFLGLTNEKIVLLSANSIRATVATESNKVATWVDETLSSVAS--------------KLEHTAQIFPELQGDKIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKN 574

HSP 4 Score: 161.77 bits (408), Expect = 1.778e-38
Identity = 124/391 (31.71%), Postives = 173/391 (44.25%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPN-SPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYD---GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                   N+NN C        TP   PDP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++  T    + Y +  L   K    +   TS+  FLG+                  +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N    S I                     +  + ++ +E QTLM HILR D +     + N   G   D     +Q  +S + DG RNI+H  V++C P SN
Sbjct:  622 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS------------------NNSNNQC--------TPGCDPDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLKTGT---WVRYCIFDLATGKAEQENNFPTSSIAFLGQ----------------NERNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLTNLPANSTIK-------------------KKAAIIIMAVEKQTLMQHILRCDYEACRQYLMNLEQGVVLDPNTQMLQTFLSHRCDGNRNILHACVSVCFPTSN 925

HSP 5 Score: 150.599 bits (379), Expect = 4.860e-35
Identity = 100/290 (34.48%), Postives = 139/290 (47.93%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRNTI--------------NNQNFCGRSNEGQL--------------PLHMGFSSRWADRLLDN----------------NIIFSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN +              N  N   R  E +               P     +++    LL                     F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDL+L V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2008 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSTANTGKCLLEVTVDRNCLEVLPTKMSYASNLKNVMNMQSRQKEAEEQNVPAEENDTSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLTLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAVAQAFLSNEKL 2294

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Xenopus
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:NCBI gene;Acc:100490232])

HSP 1 Score: 329.331 bits (843), Expect = 3.238e-89
Identity = 200/504 (39.68%), Postives = 288/504 (57.14%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   +  S    +  +   MI PP  +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L T+PN R EHLLLFLV+TV RQ  EH Q R    R        R+    N   S                MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1053 PSVVESKDRKANAHFILKLLCDSIVLQPYLRDLLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEANSS-EKEEDVFKGMICPPGTNA-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTITNLVTMPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE------DRNRKAANPEDSD---------------MPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAVAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1494

HSP 2 Score: 322.398 bits (825), Expect = 4.029e-87
Identity = 160/329 (48.63%), Postives = 220/329 (66.87%), Query Frame = 2

Query: 10112 EQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTI-VPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            +  PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L R V+K +LG  + WHDFAFF+  +YESLRQL+  ++      +           +L F I + +EE GG              + LIPNG ++ V   NV++YV+KY   RM+T+ +  L+ ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2473 DNAPLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLSRQVIKVLLGRKVNWHDFAFFDHVMYESLRQLILASQSPDADAV-------FASMDLAFAIDLCKEESGGQ-------------VELIPNGVNIPVTPQNVYEYVRKYAEHRMLTVAEQPLNAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2772

HSP 3 Score: 231.106 bits (588), Expect = 1.700e-59
Identity = 175/497 (35.21%), Postives = 257/497 (51.71%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIR---LRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVN 2026
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R   L R      +   +E  ++  + R    +LR       R + DG    +  G+ S    P    KN  TP+ ++ + LG +L++W EK          KFI I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T S K+ATWVDET++ +                ++EH    F EL+ + I  L    L +  +  + N+YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL N
Sbjct:  138 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRIGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPALDKKN--TPI-QSPVSLGEDLQWWPEK-------DGTKFISIGALYSELVAVSSKGELYQWKWMESEPYRNT---------QNLSL---------------HHPRASFLGLTNEKIVLLSANSIRATVATESNKVATWVDETLSSVAS--------------KLEHTAQIFPELQGDKIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKN 565

HSP 4 Score: 161.77 bits (408), Expect = 1.914e-38
Identity = 124/391 (31.71%), Postives = 173/391 (44.25%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPN-SPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYD---GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                   N+NN C        TP   PDP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++  T    + Y +  L   K    +   TS+  FLG+                  +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N    S I                     +  + ++ +E QTLM HILR D +     + N   G   D     +Q  +S + DG RNI+H  V++C P SN
Sbjct:  613 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS------------------NNSNNQC--------TPGCDPDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLKTGT---WVRYCIFDLATGKAEQENNFPTSSIAFLGQ----------------NERNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLTNLPANSTIK-------------------KKAAIIIMAVEKQTLMQHILRCDYEACRQYLMNLEQGVVLDPNTQMLQTFLSHRCDGNRNILHACVSVCFPTSN 916

HSP 5 Score: 150.214 bits (378), Expect = 5.323e-35
Identity = 100/290 (34.48%), Postives = 139/290 (47.93%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRNTI--------------NNQNFCGRSNEGQL--------------PLHMGFSSRWADRLLDN----------------NIIFSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN +              N  N   R  E +               P     +++    LL                     F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDL+L V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 1999 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSTANTGKCLLEVTVDRNCLEVLPTKMSYASNLKNVMNMQSRQKEAEEQNVPAEENDTSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLTLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAVAQAFLSNEKL 2285

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Xenopus
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:NCBI gene;Acc:100490232])

HSP 1 Score: 328.946 bits (842), Expect = 3.361e-89
Identity = 200/504 (39.68%), Postives = 288/504 (57.14%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   +  S    +  +   MI PP  +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L T+PN R EHLLLFLV+TV RQ  EH Q R    R        R+    N   S                MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1056 PSVVESKDRKANAHFILKLLCDSIVLQPYLRDLLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEANSS-EKEEDVFKGMICPPGTNA-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTITNLVTMPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE------DRNRKAANPEDSD---------------MPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAVAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1497

HSP 2 Score: 322.783 bits (826), Expect = 2.865e-87
Identity = 160/329 (48.63%), Postives = 220/329 (66.87%), Query Frame = 2

Query: 10112 EQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTI-VPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            +  PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L R V+K +LG  + WHDFAFF+  +YESLRQL+  ++      +           +L F I + +EE GG              + LIPNG ++ V   NV++YV+KY   RM+T+ +  L+ ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2445 DNAPLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLSRQVIKVLLGRKVNWHDFAFFDHVMYESLRQLILASQSPDADAV-------FASMDLAFAIDLCKEESGGQ-------------VELIPNGVNIPVTPQNVYEYVRKYAEHRMLTVAEQPLNAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2744

HSP 3 Score: 234.187 bits (596), Expect = 2.050e-60
Identity = 177/494 (35.83%), Postives = 259/494 (52.43%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVN 2026
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS   RR SL S + +  E  ++  + R    +LR       R + DG    +  G+ S    P    KN  TP+ ++ + LG +L++W EK          KFI I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T S K+ATWVDET++ +                ++EH    F EL+ + I  L    L +  +  + N+YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL N
Sbjct:  147 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPS--FRRSSL-SRIGSSRERDSELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPALDKKN--TPI-QSPVSLGEDLQWWPEK-------DGTKFISIGALYSELVAVSSKGELYQWKWMESEPYRNT---------QNLSL---------------HHPRASFLGLTNEKIVLLSANSIRATVATESNKVATWVDETLSSVAS--------------KLEHTAQIFPELQGDKIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKN 568

HSP 4 Score: 161.77 bits (408), Expect = 1.667e-38
Identity = 126/391 (32.23%), Postives = 176/391 (45.01%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPN-SPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYD---GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                   N+NN C        TP   PDP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++  T    + Y +  L   K    +   TS+  FLG+                  +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P       N T K   +      + ++ +E QTLM HILR D +     + N   G   D     +Q  +S + DG RNI+H  V++C P SN
Sbjct:  616 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS------------------NNSNNQC--------TPGCDPDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLKTGT---WVRYCIFDLATGKAEQENNFPTSSIAFLGQ----------------NERNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLTN-------LPA------NSTIKKKAA------IIIMAVEKQTLMQHILRCDYEACRQYLMNLEQGVVLDPNTQMLQTFLSHRCDGNRNILHACVSVCFPTSN 919

HSP 5 Score: 150.599 bits (379), Expect = 4.960e-35
Identity = 100/290 (34.48%), Postives = 139/290 (47.93%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRNTI--------------NNQNFCGRSNEGQL--------------PLHMGFSSRWADRLLDN----------------NIIFSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN +              N  N   R  E +               P     +++    LL                     F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDL+L V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 1968 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSTANTGKCLLEVTVDRNCLEVLPTKMSYASNLKNVMNMQSRQKEAEEQNVPAEENDTSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLTLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAVAQAFLSNEKL 2254

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Xenopus
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:NCBI gene;Acc:100490232])

HSP 1 Score: 328.946 bits (842), Expect = 3.420e-89
Identity = 200/504 (39.68%), Postives = 288/504 (57.14%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   +  S    +  +   MI PP  +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L T+PN R EHLLLFLV+TV RQ  EH Q R    R        R+    N   S                MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1056 PSVVESKDRKANAHFILKLLCDSIVLQPYLRDLLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEANSS-EKEEDVFKGMICPPGTNA-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTITNLVTMPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE------DRNRKAANPEDSD---------------MPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAVAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1497

HSP 2 Score: 322.783 bits (826), Expect = 2.725e-87
Identity = 160/329 (48.63%), Postives = 220/329 (66.87%), Query Frame = 2

Query: 10112 EQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTI-VPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            +  PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L R V+K +LG  + WHDFAFF+  +YESLRQL+  ++      +           +L F I + +EE GG              + LIPNG ++ V   NV++YV+KY   RM+T+ +  L+ ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2446 DNAPLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLSRQVIKVLLGRKVNWHDFAFFDHVMYESLRQLILASQSPDADAV-------FASMDLAFAIDLCKEESGGQ-------------VELIPNGVNIPVTPQNVYEYVRKYAEHRMLTVAEQPLNAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2745

HSP 3 Score: 234.187 bits (596), Expect = 1.901e-60
Identity = 177/494 (35.83%), Postives = 259/494 (52.43%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVN 2026
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS   RR SL S + +  E  ++  + R    +LR       R + DG    +  G+ S    P    KN  TP+ ++ + LG +L++W EK          KFI I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T S K+ATWVDET++ +                ++EH    F EL+ + I  L    L +  +  + N+YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL N
Sbjct:  147 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPS--FRRSSL-SRIGSSRERDSELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPALDKKN--TPI-QSPVSLGEDLQWWPEK-------DGTKFISIGALYSELVAVSSKGELYQWKWMESEPYRNT---------QNLSL---------------HHPRASFLGLTNEKIVLLSANSIRATVATESNKVATWVDETLSSVAS--------------KLEHTAQIFPELQGDKIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKN 568

HSP 4 Score: 161.77 bits (408), Expect = 1.907e-38
Identity = 124/391 (31.71%), Postives = 173/391 (44.25%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPN-SPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYD---GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                   N+NN C        TP   PDP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++  T    + Y +  L   K    +   TS+  FLG+                  +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N    S I                     +  + ++ +E QTLM HILR D +     + N   G   D     +Q  +S + DG RNI+H  V++C P SN
Sbjct:  616 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS------------------NNSNNQC--------TPGCDPDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLKTGT---WVRYCIFDLATGKAEQENNFPTSSIAFLGQ----------------NERNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLTNLPANSTIK-------------------KKAAIIIMAVEKQTLMQHILRCDYEACRQYLMNLEQGVVLDPNTQMLQTFLSHRCDGNRNILHACVSVCFPTSN 919

HSP 5 Score: 95.9005 bits (237), Expect = 1.799e-18
Identity = 82/290 (28.28%), Postives = 114/290 (39.31%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRNTI--------------NNQNFCGRSNEGQL--------------PLHMGFSSRWADRLLDN----------------NIIFSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN +              N  N   R  E +               P     +++    LL                     F G+ + +  L  RWR SLEL    F ++VG EPGSV                                 +R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2002 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSTANTGKCLLEVTVDRNCLEVLPTKMSYASNLKNVMNMQSRQKEAEEQNVPAEENDTSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSV---------------------------------DRDRDLLIQQTMRQLNNHFGRRCATT---PMAVHRVKVTFKDEPGEGSGVARSFYTAVAQAFLSNEKL 2255

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Xenopus
Match: UBR5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:NCBI gene;Acc:100490232])

HSP 1 Score: 328.946 bits (842), Expect = 3.608e-89
Identity = 200/504 (39.68%), Postives = 288/504 (57.14%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   +  S    +  +   MI PP  +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L T+PN R EHLLLFLV+TV RQ  EH Q R    R        R+    N   S                MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1066 PSVVESKDRKANAHFILKLLCDSIVLQPYLRDLLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEANSS-EKEEDVFKGMICPPGTNA-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTITNLVTMPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE------DRNRKAANPEDSD---------------MPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAVAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1507

HSP 2 Score: 322.398 bits (825), Expect = 3.989e-87
Identity = 160/329 (48.63%), Postives = 220/329 (66.87%), Query Frame = 2

Query: 10112 EQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTI-VPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            +  PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L R V+K +LG  + WHDFAFF+  +YESLRQL+  ++      +           +L F I + +EE GG              + LIPNG ++ V   NV++YV+KY   RM+T+ +  L+ ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2489 DNAPLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLSRQVIKVLLGRKVNWHDFAFFDHVMYESLRQLILASQSPDADAV-------FASMDLAFAIDLCKEESGGQ-------------VELIPNGVNIPVTPQNVYEYVRKYAEHRMLTVAEQPLNAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2788

HSP 3 Score: 231.106 bits (588), Expect = 1.810e-59
Identity = 175/497 (35.21%), Postives = 257/497 (51.71%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIR---LRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVN 2026
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R   L R      +   +E  ++  + R    +LR       R + DG    +  G+ S    P    KN  TP+ ++ + LG +L++W EK          KFI I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T S K+ATWVDET++ +                ++EH    F EL+ + I  L    L +  +  + N+YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL N
Sbjct:  151 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRIGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPALDKKN--TPI-QSPVSLGEDLQWWPEK-------DGTKFISIGALYSELVAVSSKGELYQWKWMESEPYRNT---------QNLSL---------------HHPRASFLGLTNEKIVLLSANSIRATVATESNKVATWVDETLSSVAS--------------KLEHTAQIFPELQGDKIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKN 578

HSP 4 Score: 162.155 bits (409), Expect = 1.595e-38
Identity = 126/391 (32.23%), Postives = 176/391 (45.01%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPN-SPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYD---GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                   N+NN C        TP   PDP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++  T    + Y +  L   K    +   TS+  FLG+                  +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P       N T K   +      + ++ +E QTLM HILR D +     + N   G   D     +Q  +S + DG RNI+H  V++C P SN
Sbjct:  626 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS------------------NNSNNQC--------TPGCDPDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLKTGT---WVRYCIFDLATGKAEQENNFPTSSIAFLGQ----------------NERNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLTN-------LPA------NSTIKKKAA------IIIMAVEKQTLMQHILRCDYEACRQYLMNLEQGVVLDPNTQMLQTFLSHRCDGNRNILHACVSVCFPTSN 929

HSP 5 Score: 150.214 bits (378), Expect = 5.244e-35
Identity = 100/290 (34.48%), Postives = 139/290 (47.93%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRNTI--------------NNQNFCGRSNEGQL--------------PLHMGFSSRWADRLLDN----------------NIIFSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN +              N  N   R  E +               P     +++    LL                     F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDL+L V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2012 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSTANTGKCLLEVTVDRNCLEVLPTKMSYASNLKNVMNMQSRQKEAEEQNVPAEENDTSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLTLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAVAQAFLSNEKL 2298

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Mouse
Match: Ubr5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:MGI Symbol;Acc:MGI:1918040])

HSP 1 Score: 332.028 bits (850), Expect = 3.155e-90
Identity = 201/504 (39.88%), Postives = 289/504 (57.34%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   + VS    +  + + M+ P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L TLPN R EHLLLFLV+TV RQ  EH Q R    R           +    TAS   S            MP++ LEP  FA  AL+ VL +W ++ ++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1073 PSVVESKDRKANAHFILKLLCDSAVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAE-VSASEKEEDVFMGMVCPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE----------DRNRKTASPEDS-----------DMPDHDLEPPRFAQLALERVLQDWNALRSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAIAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1514

HSP 2 Score: 324.324 bits (830), Expect = 7.441e-88
Identity = 160/326 (49.08%), Postives = 219/326 (67.18%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL+  ++ +    +  A        +L F I   +EEGG              + LIPNG ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK++L  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2501 APLFYQPGKRGFYTPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSA-------MDLAFAIDLCKEEGGG------------QVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2798

HSP 3 Score: 224.557 bits (571), Expect = 1.293e-57
Identity = 175/499 (35.07%), Postives = 255/499 (51.10%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSS---MANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLV-----LGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSL 2020
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R    S   S   +   +E  ++  + R    +LR       R + DG       NE  + S +     ES P KKN  V     LG +L++W +K          KF  I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T + K+ATWVDET++ +                ++EH    +SEL+ E I  L    L +  +  + N+YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL
Sbjct:  157 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFD---NERGSTSKE----GESNPDKKNTPVQSPVSLGEDLQWWPDK-------DGTKFTCIGALYSELLAVSSKGELYQWKWSESEPYRNA---------QNPSL---------------HHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVAS--------------KLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESL 582

HSP 4 Score: 152.14 bits (383), Expect = 1.148e-35
Identity = 124/390 (31.79%), Postives = 179/390 (45.90%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYD-GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                     N  C     NS+ P++ DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS+  FLG+                + ++  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P       N T K   +      + ++ +E QTLM HILR D +     + N   AV  E +   +Q  IS + DG RNI+H  V++C P SN
Sbjct:  632 KRRRSTPAPREEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS--------------------TNTTCQ----NSSGPDA-DPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLK---TGSWVRYCVFDLATGKAEQENNFPTSSVAFLGQ----------------DERSVAIFTAGQESPIVLRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLIN-------LPA------NSTIKKKAA------IIIMAVEKQTLMQHILRCDYEACRQYLVNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN 935

HSP 5 Score: 143.665 bits (361), Expect = 4.870e-33
Identity = 73/138 (52.90%), Postives = 94/138 (68.12%), Query Frame = 2

Query: 8030 FSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDLSL V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2175 FMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL 2309

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Mouse
Match: Ubr5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:MGI Symbol;Acc:MGI:1918040])

HSP 1 Score: 332.028 bits (850), Expect = 3.630e-90
Identity = 201/504 (39.88%), Postives = 289/504 (57.34%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   + VS    +  + + M+ P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L TLPN R EHLLLFLV+TV RQ  EH Q R    R           +    TAS   S            MP++ LEP  FA  AL+ VL +W ++ ++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1067 PSVVESKDRKANAHFILKLLCDSAVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAE-VSASEKEEDVFMGMVCPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE----------DRNRKTASPEDS-----------DMPDHDLEPPRFAQLALERVLQDWNALRSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAIAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1508

HSP 2 Score: 324.324 bits (830), Expect = 7.297e-88
Identity = 160/326 (49.08%), Postives = 219/326 (67.18%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL+  ++ +    +  A        +L F I   +EEGG              + LIPNG ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK++L  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2495 APLFYQPGKRGFYTPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSA-------MDLAFAIDLCKEEGGG------------QVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2792

HSP 3 Score: 224.942 bits (572), Expect = 1.020e-57
Identity = 175/496 (35.28%), Postives = 255/496 (51.41%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLV-----LGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSL 2020
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS    R S  S + +  E  ++  + R    +LR       R + DG       NE  + S +     ES P KKN  V     LG +L++W +K          KF  I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T + K+ATWVDET++ +                ++EH    +SEL+ E I  L    L +  +  + N+YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL
Sbjct:  157 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSF---RRSSLSRLGSSRERDSELLRERESVLRLRE------RRWLDGASFD---NERGSTSKE----GESNPDKKNTPVQSPVSLGEDLQWWPDK-------DGTKFTCIGALYSELLAVSSKGELYQWKWSESEPYRNA---------QNPSL---------------HHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVAS--------------KLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESL 576

HSP 4 Score: 152.14 bits (383), Expect = 1.280e-35
Identity = 124/390 (31.79%), Postives = 179/390 (45.90%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYD-GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                     N  C     NS+ P++ DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS+  FLG+                + ++  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P       N T K   +      + ++ +E QTLM HILR D +     + N   AV  E +   +Q  IS + DG RNI+H  V++C P SN
Sbjct:  626 KRRRSTPAPREEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS--------------------TNTTCQ----NSSGPDA-DPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLK---TGSWVRYCVFDLATGKAEQENNFPTSSVAFLGQ----------------DERSVAIFTAGQESPIVLRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLIN-------LPA------NSTIKKKAA------IIIMAVEKQTLMQHILRCDYEACRQYLVNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN 929

HSP 5 Score: 143.665 bits (361), Expect = 4.667e-33
Identity = 73/138 (52.90%), Postives = 94/138 (68.12%), Query Frame = 2

Query: 8030 FSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDLSL V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2169 FMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL 2303

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Mouse
Match: Hace1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:2446110])

HSP 1 Score: 100.908 bits (250), Expect = 2.051e-20
Identity = 78/303 (25.74%), Postives = 137/303 (45.21%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIG-MNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP-------ASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            N +R  G+++G+++   + + +   R   K+ILG+P+ + D A  + +  ++L+ ++               ++ + +  L  T            S +  V G M  + L P G  + V  NN  +YV+     RM   ++PQ++    G +  +P   +      +L LLL+G  EI+V   I  T +        ++  E+     +WFW+VV      +R  LL F T S  +P           G Q   TI   P     LPT++TCI+ L +P Y +K IL+++LL A+   S+G+
Sbjct:  639 NYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWIL---------------DNDISDLGLELTF-----------SVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEY--------TSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNF-TIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGY 906

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Mouse
Match: Huwe1 (HECT, UBA and WWE domain containing 1 [Source:MGI Symbol;Acc:MGI:1926884])

HSP 1 Score: 100.523 bits (249), Expect = 5.732e-20
Identity = 76/300 (25.33%), Postives = 135/300 (45.00%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITIRPADDF--HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            ++ VGR++  ++  N  +     R   K+ILG  + + D    +   Y+ L  L++   +   +G           Y+L F+   +E              G+  + +L PNG ++ V   N  +YV   C  RM   ++ QL     G Y+++PK  ++  + ++L LL++G   I+++ L S T +    S +I           +WFW+ + +F+   R   L F T +  +P    A+ +G   +    I   D     LP+A+TC ++L +P Y +   LR  LL AI+  S GF
Sbjct: 4110 FKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLE--NDVSTLG-----------YDLTFSTEVQE-------------FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQ---------IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGF 4374

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Mouse
Match: Huwe1 (HECT, UBA and WWE domain containing 1 [Source:MGI Symbol;Acc:MGI:1926884])

HSP 1 Score: 100.138 bits (248), Expect = 6.181e-20
Identity = 76/300 (25.33%), Postives = 135/300 (45.00%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITIRPADDF--HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            ++ VGR++  ++  N  +     R   K+ILG  + + D    +   Y+ L  L++   +   +G           Y+L F+   +E              G+  + +L PNG ++ V   N  +YV   C  RM   ++ QL     G Y+++PK  ++  + ++L LL++G   I+++ L S T +    S +I           +WFW+ + +F+   R   L F T +  +P    A+ +G   +    I   D     LP+A+TC ++L +P Y +   LR  LL AI+  S GF
Sbjct: 4111 FKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLE--NDVSTLG-----------YDLTFSTEVQE-------------FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQ---------IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGF 4375

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. UniProt/SwissProt
Match: sp|O95071|UBR5_HUMAN (E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2)

HSP 1 Score: 330.487 bits (846), Expect = 7.358e-89
Identity = 200/504 (39.68%), Postives = 290/504 (57.54%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   + +S    +  + + M+ P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L TLPN R EHLLLFLV+TV RQ  EH Q R    R           +    TAS   S            MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1073 PSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAE-ISSSEKEEDVFMGMVCPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE----------DRNRKTASPEDS-----------DMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAIAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1514

HSP 2 Score: 323.939 bits (829), Expect = 6.110e-87
Identity = 160/326 (49.08%), Postives = 219/326 (67.18%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL+  ++ +    +  A        +L F I   +EEGG              + LIPNG ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK++L  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2502 APLFYQPGKRGFYTPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSA-------MDLAFAIDLCKEEGGG------------QVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2799

HSP 3 Score: 224.942 bits (572), Expect = 7.270e-57
Identity = 174/497 (35.01%), Postives = 259/497 (52.11%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSS---MANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVN 2026
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R    S   S   +   +E  ++  + R    +LR       R + DG    +  G+ S    P+   KN  TPV ++ + LG +L++W +K          KFI I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T + K+ATWVDET++ +                ++EH    +SEL+ E I  L    L +  +  + ++YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL N
Sbjct:  157 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPNLDKKN--TPV-QSPVSLGEDLQWWPDK-------DGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNA---------QNPSL---------------HHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVAS--------------KLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKN 584

HSP 4 Score: 154.066 bits (388), Expect = 2.063e-35
Identity = 126/390 (32.31%), Postives = 179/390 (45.90%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYD-GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                    +N  C     NS+ P++ DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS+  FLG+                  +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P       N T K   +      V ++ +E QTLM HILR D +     + N   AV  E +   +Q  IS + DG RNI+H  V++C P SN
Sbjct:  632 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS--------------------SNTNCQ----NSSGPDA-DPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLK---TGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQ----------------NERNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLIN-------LPA------NSTIKKKAA------VIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN 935

HSP 5 Score: 152.525 bits (384), Expect = 6.352e-35
Identity = 104/291 (35.74%), Postives = 143/291 (49.14%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRN-----------------TINNQNFCGRSNEGQ--LPLHM-----GFSSRWADRLLDNNIIFS-------GVPVGNLRT----------------RWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN                  +N QN   +  E Q  LP        G S+      L ++++         G P+ + R                 RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDLSL V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2022 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL 2309

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. UniProt/SwissProt
Match: sp|Q62671|UBR5_RAT (E3 ubiquitin-protein ligase UBR5 OS=Rattus norvegicus OX=10116 GN=Ubr5 PE=1 SV=3)

HSP 1 Score: 330.487 bits (846), Expect = 7.898e-89
Identity = 201/504 (39.88%), Postives = 289/504 (57.34%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R YP A+ +L+    +   + VS    +  + + M+ P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L TLPN R EHLLLFLV+TV RQ  EH Q R    R           +    TAS   S            MP++ LEP  FA  AL+ VL +W ++ ++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1062 PSVVESKDRKANAHFILKLLCDSAVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAE-VSGSEKEEDVFMGMVCPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE----------DRNRKTASPDDS-----------DMPDHDLEPPRFAQLALERVLQDWNALRSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAIAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1503

HSP 2 Score: 323.553 bits (828), Expect = 8.956e-87
Identity = 159/326 (48.77%), Postives = 219/326 (67.18%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL+  ++ +    +  A        +L F +   +EEGG              + LIPNG ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK++L  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2491 APLFYQPGKRGFYTPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSA-------MDLAFAVDLCKEEGGG------------QVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2788

HSP 3 Score: 223.787 bits (569), Expect = 1.752e-56
Identity = 173/497 (34.81%), Postives = 252/497 (50.70%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRES-------LYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSL 2020
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R    S       L   +  D E   +R    RL            R + DG    +  G+ S    P+   KN  TPV ++ + LG +L++W +K          KF  I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T + K+ATWVDET++ +                ++EH    +SEL+ E I  L    L +  +  + N+YWWGV+PF  RK  +EK R +  K +     Q             + N+  G  VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL
Sbjct:  147 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLR----------ERRWLDGASFDNERGSTSKEGEPNPDKKN--TPV-QSPVSLGEDLQWWPDK-------DGTKFTCIGALYSELVAVSSKGELYQWKWTESEPYRNA---------QNPSL---------------HHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVAS--------------KLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGVQ-------------SLNVRGGRQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESL 571

HSP 4 Score: 152.14 bits (383), Expect = 8.654e-35
Identity = 103/291 (35.40%), Postives = 143/291 (49.14%), Query Frame = 2

Query: 7751 FFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFG---------------VLRRFEIDRN-----------------TINNQNFCGRSNEGQLPL-------HMGFSSRWADRLLDNNIIFS-------GVPVGNLRT----------------RWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            FF R+D       +  + F+ P++E++PLA  P LLQP    +++FG                L    +DRN                  +N QN   ++ E Q  L         G S+      L ++++         G P+ + R                 RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDLSL V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2012 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVTMDRNCLEVLPTKMSYAANLKNVMNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL 2299

HSP 5 Score: 151.754 bits (382), Expect = 1.050e-34
Identity = 124/390 (31.79%), Postives = 179/390 (45.90%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYD-GFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                    +N  C     NS+ P++ DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS+  FLG+                  ++  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P       N T K   +      + ++ +E QTLM HILR D +     + N   AV  E +   +Q  IS + DG RNI+H  V++C P SN
Sbjct:  621 KRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS--------------------SNTNCQ----NSSGPDA-DPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLK---TGNWVRYCIFDLATGKAEQENNFPTSSVAFLGQ----------------NERSVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLIN-------LPA------NSTIKKKAA------IIIMAVEKQTLMQHILRCDYEACRQYLVNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN 924

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. UniProt/SwissProt
Match: sp|P51592|HYD_DROME (E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster OX=7227 GN=hyd PE=1 SV=3)

HSP 1 Score: 329.717 bits (844), Expect = 1.163e-88
Identity = 167/325 (51.38%), Postives = 222/325 (68.31%), Query Frame = 2

Query: 10121 PLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            PLF+ PG  GFY PR+         + R N +R++GR+IG+ +L NE +PL L RHVLKYILG  I +HD AFF+  LYES RQ+++ A+  +        E+ +    L F I   +EEG     G+R+        LIP G DV V S+N+F+YV++Y   R+I   +  L+ +K+GV+DVLP +++  L+ EDLRLLLNG  +INV  LISYT+F DESS       +K+ KFKKWFW +V   N ++RQ+L+YFWT SPALPAS +GFQP+P++TIRPADD HLPTANTCISRLYIPLYS+K ILR K+L AI++K+FGFV
Sbjct: 2589 PLFYSPGKRGFYTPRQ-----GFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKE-------GEETINRMELCFVIDLMKEEG----CGNRE--------LIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESS----EGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2885

HSP 2 Score: 324.324 bits (830), Expect = 5.350e-87
Identity = 198/501 (39.52%), Postives = 278/501 (55.49%), Query Frame = 2

Query: 3989 PPIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGR-RHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P    D  ++R ++  I+  +   P +  +L  +LS ++A GQTPFM SVS R Y   + LL+ I+ L +           QL  +MIFP                + +PL V+C ND CSFTWTG DHI Q+IFEC+TCGLT SLCCCTECARVCHKGHDC LK+T+PTAYCDCWEKC+CKALI G+ + R  LL KL+  TDL T  N + E +LLFL++TV RQ  E +Q R S R R+ ++      GNN      S +S  +      +  MP++ LEP  FA  AL+ +L +W +V ++++SG     V N   +   +S ++G N      +F+  Q  S  LD+F  +LI K  S  +D LL TL +ELQN      +       + +    R +RSVARVFV   L+  P+   KR+S+   N         K +  C ++F+ L  +S+ EL  ++  +IAPVR G+++PT   A F   S  + N D +F
Sbjct: 1119 PTYTFDLAQRREHALTILQQMCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQD--------PQLKEAMIFPNGSPA-----------DQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNN------SVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFN------MFIQTQHGSTLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRS------KEAEEVVRRFVRSVARVFVIFNLEKQPN-PEKRKSHSSCN---------KYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPT---APFTMSSSNLDNSDDLF 1569

HSP 3 Score: 144.05 bits (362), Expect = 2.131e-32
Identity = 86/295 (29.15%), Postives = 138/295 (46.78%), Query Frame = 2

Query: 1118 DCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSV 2002
            D  K E +P+  + + +   L+ W EK         ++F  I  +YSE I ++   DL+QWRW D+EP+ S          +  N+               YH +  SLN+  E++  +SA   R +V+T + ++ATW+DE +  I                ++EH    F+E   ++I +++  +L + V+  S NIYWWGV+PF  R+   +K R +T K                       +I  G+ V MK  P++ +G+IGFT   GVPK+G LL   W   D+CR  +
Sbjct:  333 DSKKKEPSPML-SPIWISEELQPWPEK-------SSVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYKS----------ETENV---------------YHPKTVSLNIV-ERVELISANFIRCSVVTETNRVATWMDEQLGYI--------------GAKLEHSCCAFNEFISDSITKIYVCSLYTVVKTESNNIYWWGVLPFDQRRFLWDKFRTKTKKP----------------FKVVATDINVGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDVCRMKI 563

HSP 4 Score: 116.316 bits (290), Expect = 6.183e-24
Identity = 64/134 (47.76%), Postives = 86/134 (64.18%), Query Frame = 2

Query: 8030 FSGVPVGN-LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLI-VNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLS 8425
            FS +P  N L +RW+ +L+L    F  +VG+E GSVL +   F +KE RFR+ MEKLRN  +RDL L  + R R  +I  T  +LNT++  + S   Q P+  +R KV F DEPGEG+GVARSF T  AEA+L+
Sbjct: 2278 FSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQ-SRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLA 2410

HSP 5 Score: 114.775 bits (286), Expect = 1.824e-23
Identity = 117/405 (28.89%), Postives = 180/405 (44.44%), Query Frame = 2

Query: 2483 TDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVET 3694
            +D   +  HKR      K + +   PQ +  ++EE W +KDV+F+ED +  PVG VLKVDG   AV+F         A+N      AA   ++ +  + TS      +      W   CRLLR+E++ + +  + +R PD +QK PK I   V  +A          IL +AV++  IH++  K    K I Y L +L   K   +    T  N F+G  P   L+A   +             +     I LRDGNG +YPL      + + + S    I  P W DLPPV+ +    +++        ++ G N  S             ++ +  L+ ++Q LM HILR D K     +       + D  +  ++ E+ DG RNI H  V MC P SN ++
Sbjct:  635 SDTGSVTSHKRTKRATTKEDSNA--PQ-EGRKDEELWEVKDVVFVED-KVGPVGKVLKVDGDFVAVRF--------PAINAAAVAAAAAATSSTSNTASTSKEEGKEDD-----W-QQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKI--NVGGDAAGAQ------ILTLAVDSRGIHVI--KKVLGK-IHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDC------------SGNSSTIVLRDGNGALYPL------AKDCLGS----IKDPQWFDLPPVKSITMSTISL------PAMLSGVNLKS-------------KVCMTALLFDTQKLMPHILRCDVKNSFAALGRLEREDQADTAL--VVEERCDGARNIFHACVIMCAPSSNKDS 967

HSP 6 Score: 75.0998 bits (183), Expect = 1.808e-11
Identity = 36/47 (76.60%), Postives = 41/47 (87.23%), Query Frame = 2

Query:  635 IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSR 775
            + A+ VPE+LI Q + VLQGKSR LIIRELQRTNLDVN+AVNNLLSR
Sbjct:  150 VPATYVPEELISQAEVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSR 196

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. UniProt/SwissProt
Match: sp|Q80TP3|UBR5_MOUSE (E3 ubiquitin-protein ligase UBR5 OS=Mus musculus OX=10090 GN=Ubr5 PE=1 SV=2)

HSP 1 Score: 328.561 bits (841), Expect = 2.750e-88
Identity = 200/504 (39.68%), Postives = 288/504 (57.14%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLN-----KELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   ++ +L  LLS ++A G TPFM +VS R Y  A+ +L+    +   + VS    +  + + M+ P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  SAR +LL +LL  T+L TLPN R EHLLLFLV+TV RQ  EH Q R    R           +    TAS   S            MP++ LEP  FA  AL+ VL +W ++ ++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K    + DILL         KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  CKR+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DA++  +++F
Sbjct: 1067 PSVVESKDRKANAHFILKLLCDSAVLQPYLRELLSAKDARGMTPFMSAVSGRAYSAAITILETAQKIAKAE-VSASEKEEDVFMGMVCPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRE----------DRNRKTASPEDS-----------DMPDHDLEPPRFAQLALERVLQDWNALRSMIMFGSQEN-----KDPLSASSRIGHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKC---TADILLLDTLLGTLVKELQNKYT------PGRREEAIAVTMRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELF 1508

HSP 2 Score: 324.709 bits (831), Expect = 3.770e-87
Identity = 160/326 (49.08%), Postives = 219/326 (67.18%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL+  ++ +    +  A        +L F I   +EEGG              + LIPNG ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK++L  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2495 APLFYQPGKRGFYTPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSA-------MDLAFAIDLCKEEGGG------------QVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2792

HSP 3 Score: 224.942 bits (572), Expect = 7.382e-57
Identity = 175/496 (35.28%), Postives = 255/496 (51.41%), Query Frame = 2

Query:  569 RVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLV-----LGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSL 2020
            +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS    R S  S + +  E  ++  + R    +LR       R + DG       NE  + S +     ES P KKN  V     LG +L++W +K          KF  I  +YSEL+ +++  +L+QW+W +SEP+ +          QN ++               +H R   L L  EKI+ LSA S RATV T + K+ATWVDET++ +                ++EH    +SEL+ E I  L    L +  +  + N+YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F++  G+PK+G L+E  W + D CRF +R  +SL
Sbjct:  157 QTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSF---RRSSLSRLGSSRERDSELLRERESVLRLRE------RRWLDGASFD---NERGSTSKE----GESNPDKKNTPVQSPVSLGEDLQWWPDK-------DGTKFTCIGALYSELLAVSSKGELYQWKWSESEPYRNA---------QNPSL---------------HHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVAS--------------KLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSM--------------PNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESL 576

HSP 4 Score: 152.525 bits (384), Expect = 6.509e-35
Identity = 120/390 (30.77%), Postives = 174/390 (44.62%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF---AVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF   S                     N  C     NS+ P++ DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS+  FLG+                + ++  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N    S I                     +  + ++ +E QTLM HILR D +     + N     V  +    +Q  IS + DG RNI+H  V++C P SN
Sbjct:  626 KRRRSTPAPREEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTS--------------------TNTTCQ----NSSGPDA-DPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT-------------EILAVNVDSKGVHAVLK---TGSWVRYCVFDLATGKAEQENNFPTSSVAFLGQ----------------DERSVAIFTAGQESPIVLRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISSLGMGVHSLINLPANSTIK-------------------KKAAIIIMAVEKQTLMQHILRCDYEACRQYLVNLEQAVVLEQNRQMLQTFISHRCDGNRNILHACVSVCFPTSN 929

HSP 5 Score: 143.665 bits (361), Expect = 3.292e-32
Identity = 73/138 (52.90%), Postives = 94/138 (68.12%), Query Frame = 2

Query: 8030 FSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRNQ  RDLSL V+R+R+L+I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS E L
Sbjct: 2169 FMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKL 2303

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. UniProt/SwissProt
Match: sp|P51593|HUWE1_RAT (E3 ubiquitin-protein ligase HUWE1 (Fragment) OS=Rattus norvegicus OX=10116 GN=Huwe1 PE=1 SV=2)

HSP 1 Score: 99.3673 bits (246), Expect = 1.599e-20
Identity = 76/300 (25.33%), Postives = 134/300 (44.67%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITIRPADDF--HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            ++ VGR++  ++  N  +     R   K+ILG  + + D    +   Y+ L  L++              +   L Y+L F+   +E              G+  + +L PNG ++ V   N  +YV   C  RM   ++ QL     G Y+++PK  ++  + ++L LL++G   I+++ L S T +    S +I           +WFW+ + +F+   R   L F T +  +P    A+ +G   +    I   D     LP+A+TC ++L +P Y +   LR  LL AI+  S GF
Sbjct:   55 FKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLE-------------NDVSTLGYDLTFSTEVQE-------------FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQ---------IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGF 319

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. TrEMBL
Match: A0A0X3PZ81 (Uncharacterized protein (Fragment) OS=Schistocephalus solidus OX=70667 GN=TR160145 PE=4 SV=1)

HSP 1 Score: 941.414 bits (2432), Expect = 0.000e+0
Identity = 694/2001 (34.68%), Postives = 1013/2001 (50.62%), Query Frame = 2

Query:   53 MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLXXXXXXXXXXXXXXXXXXENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAE---ENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDIFP---SIRLRRESLYSSMANDIESFADXXXXXXLDCQ-LRNSADPLPRTFPDGTCVSR--------NGNESPTFSPDDC--GKNESTPVKKNCLV-LGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQ-------------NSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQN-----LRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDR--------------TPKTEVKYNGQXXXXXXX-----XXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSIN-PASFDPLT------HAHMCPQLNTSFLYGLLGSS-NKSINIAEN----NQNTTDSINVTGSSSNYKMPTTWAEMXXXXXXXXXTCSDQSGPVKISPGTFKRKKQSVNTSGTGD----LVAEVNTEXXXXXXXXXXXXXXXCS----DTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFG---------NNNNACSE----TSINSTTPNS--------PDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPT------TLSPC--FGILGMAVENELIHLLVRK----------STSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNI--KSPIIPGSNSNSTN-DTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETEW--KLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSMNISSFPYRRWIDMGRPINDVNQFN----YSRSNDRQASSVRFT----------VMXXXXXXXXXILTGDSNSGWLLPPIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLA--LSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPM--------------------------PEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDG-INPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHP-----------LTMKPPTQT--------------KVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYS 5494
            MS  F FV   S +  +   +Q++L + LK  S+Q+K+DGV     L+ L Q  I E V+G + +AFRL+DGRVCR  + ++ +     +EK + R S    D       ++ S+RS+                       G  A   S R+ L   + R+         A  ++F+REMQRQGIY AR   + I A++VPE LIEQCQTVLQGKSRQLI+RELQRTNLDVNMAVNNLLSRDDEA+    +G   AP   E+ +D    L           + +   G+T+++     S RLR E L S    D  S++DRRKRRRLD      SAD            SR        + ++ P  + +D     N   P K    V LG  LEFW     D        F  IA +YSEL+ +T+  +LHQW+W  +EP+      SN++  Q             ++++   +    +  +  + H R  SL + GEKI+ LSAC +RA+V+TASG +A+++D+ +  + Q   +S  +    +      R EHP  +F ELK ETI +++T+ L+S V+C SGN+YWWGV P   R+  +++ R++              T  +    N +    +        A  +    + PG  VCMKNAP+FHAGA+GFT++ G+PK+G LLEDAWK+ D+CRF V+    L +   +   + +QS    +S D ++      HA  CP    ++   +  +S + S  +A+        T DS  V G  S+  +     EMPPPPSPASSTCSDQSGP+K+SPGTFKRKK    +S  G+     VA  ++E+   +++         S     TEK +     T       H   LT     N S         EE EDWCL DV+F+EDGRTQPVGV+LKVDG+IAAVKFLK+ +RAC+A NC  SP+  +           ++  AC +    T +N +   S        PDP++WLNDCRLL+K++L+VVK   + RVPD VQ  P+ IPT  FL +K +      T + C    ++ +A EN  IH +V +           +  K +EY + +L  K +SSHRL   + G     P+P          Y +L     +     RP+ LRD  G V+P L           S  EP   P WLDLP ++C    +++ +  +    S   P   +  +N   +K +KS+  R+L GV+V+   +LM +I+R +D+KV   + + A  +     VQ ++ E  DG RNI+H+AV MC P SN E EW  +L +IL  +S+    N  + +  Q  +W+L      +S P    +++G   +  +       + RS+    ++   T          V S      +   T   ++ W LPP+  D+  +R  SYRI+ +++  P +  +L  LLS    DG TPFM ++  + Y +A FLLD ++DL +++  S   S+   +  +  +FPP           SS  +D+PL +LC ND CSFTWTGP+HIR DIFECRTCGL +SLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC C++LI+G  S R  L ++LL+ TDL  LPN R EHL+++L K+V+RQ RE KQ R S RR       +          ++  +      P    P+                          PE+ LEP  F  +AL+ VL +  +  +LL                      DG  +P  D++ F+  QS + QLD+FVFTL+ K     +  LL+TL+  L+   S P           + ++ P+                  +   AR +RSVARV+ ++ L +APD  +K+   RLS+       Q +PL++C+ +F +L  V+  EL  +A  +++PVR G L+P+A Y    Q ++A+   DQ+  S
Sbjct:   13 MSCPFVFVSKPSKDVNSHSQLQSDLVDCLKRISDQVKKDGVSAPEVLRPLFQSRIIESVIGPSHIAFRLEDGRVCRVAYFLRPDSIPTLEEKRKARSSDMRNDSHYNREVSSGSTRSS-----------------------GASAALRSMRSPL-GVLGRH---------ARGLSFLREMQRQGIYLARPISSQIPAADVPESLIEQCQTVLQGKSRQLIVRELQRTNLDVNMAVNNLLSRDDEADLGGSSGTVGAPSATEDWEDEAEDLFSIFEHPEGHLLFESETGVTDELLDRAFSPRLRGE-LGSDY--DYTSYSDRRKRRRLDAHSYVRSADTYGGRSTSSYIESRRFWRSIPGSSDDQPQRADEDIYDSANPQIPSKNRYYVYLGDKLEFWPPSTSD---TPGFVFTAIAALYSELLAVTSSGELHQWKWKSTEPYGFQACESNNSFSQRLTFPIFNDRPTLDTDVASGATATQTATVN-HRHPRAASLGINGEKIVSLSACITRASVVTASGAIASFMDDVLPALLQATASSSSSSNALSLRSAVARFEHPATRFLELKHETIRKVYTAPLISVVQCESGNVYWWGVYPSYMRQRTVDRLRNQKQPVSTNASSPIQSTGHSRTNVNSRSRHTSTGPPGTLTAQPEPARPVGPGDLVCMKNAPVFHAGAVGFTLVNGLPKVGVLLEDAWKLTDVCRFRVKSPSILTSLSLSSCLDPIQSARLQSSMDQVSQTESALHAFACPHAIAAWNNNIPSTSFDVSAALADGVPPAAPATADS-GVGGPGSSLSL-----EMPPPPSPASSTCSDQSGPIKVSPGTFKRKKVPSTSSDRGERGTTTVARASSEAEGRASSPVGGQLRGSSRRTTSTEKESTEFGGTRSATKRQHSS-LTNRAGGNSSES-------EELEDWCLNDVVFVEDGRTQPVGVLLKVDGNIAAVKFLKEQDRACLAANCTLSPVCMLINSITAGVPPPSSAAACGQQSQLTKLNPSATKSSAGASSLPPDPMTWLNDCRLLKKDDLMVVKPTGLQRVPDFVQHSPRKIPTS-FLSSKASGETGSGTTTACNRKKLISIAPENGRIHAIVERLLDNPASGPPPSDPKTLEYHVFTLNGKTVSSHRLPILSQG----CPRPA---------YDQLA----YTCPAERPLLLRDSAGVVFPFL-------PTPRSGQEPWVFPQWLDLPSIQCAALSWLSPSCLSAFGDSQANPSPGATDSNLKKNKEAKSRIPRILFGVIVVSETSLMQYIVRAEDQKVEEALRSLATSTTTK--VQSVVHELADGHRNILHMAVLMCAPQSNREAEWSDRLVSILANQSEGKFKNLELRNPGQ--SWNL----TPTSKPLFSLLNLGSSRSGASGLTMHDLFIRSSIEAVTTPAHTTSDQETQGDVVASQPAFPSAPPTTTAGSNFWYLPPVSTDDFTRRQASYRILRLLLRDPTLRPYLRQLLSSVTDDGMTPFMLAIQCKAYQVANFLLDFLVDLENIRPESQTTSQFSYSPLMKYLFPP-----------SSCLDDSPLFMLCYNDTCSFTWTGPNHIRLDIFECRTCGLMDSLCCCTECARVCHKGHDCRLKRTSPTAYCDCWEKCCCRSLILGSQSMRLSLFERLLRETDLVYLPNGRGEHLMVYLTKSVERQCREQKQYRPSRRRLGPITSRSVIAAAAAAAVTTTPTGANADAPTSASPLSGRTQSGGVTSADVTGRGNGGASSDEPEHDLEPPTFCRDALELVLESKSAAASLLC--------------------GDGPPSPSKDEQPFMAIQSGASQLDEFVFTLLCKCPPELLHRLLSTLSTSLEEHLSAPRREKNLLRFLRIGLQQPSSESTSVDHSDSSSSFLACRHGIARFVRSVARVYTSIVLGLAPDHYKKKP--RLSS-------QSQPLELCRLVFLHLAPVACVELSLLAVGLLSPVRTGGLRPSAIYTLTSQTNEAIHAFDQVITS 1886

HSP 2 Score: 369.392 bits (947), Expect = 5.089e-98
Identity = 186/349 (53.30%), Postives = 241/349 (69.05%), Query Frame = 2

Query: 10109 PEQTPLFWQPGHPGFYCPRRVNLN---DNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGN--GNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSC---------------TISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            PE+ PLFWQPG  GFY PR V+ +   D+     R  IYR +GRVIG+ +L NET PL+  RHVLKYILG P+ WHDFAFF+S +YE LRQL+     A+  G +    D +L+YNL F+++   EEGG+  G S            L+P G+ +DV+S N++++VK+Y   +M  ++   L+ I+ GV+DVLP +AL+GL+ EDLRLLLNG  +INV+ L+ YT+FLDES                 T+ N+ ++V + K+WFW VV + ++ QRQ+LLYFWTSSPALPAS  GFQPMPTITIRP DD HLPTANTCISRLY+PLYS+K ILREKLLQAI+TK FGFV
Sbjct: 3467 PERAPLFWQPGLGGFYSPRAVSQSPSIDSAALQCRYTIYRCIGRVIGLCLLTNETCPLRFNRHVLKYILGRPLCWHDFAFFDSTVYEGLRQLLLYTTPARPEGTS----DSILDYNLTFSLLAAPEEGGSVRGPSAQHP--------LVPGGDKIDVNSVNIYEFVKRYAEFKMREVINEPLEHIRLGVFDVLPHNALDGLTSEDLRLLLNGVSDINVDTLVGYTTFLDESGASAFIALSEGTAGSGVTVPNAADRVARLKRWFWNVVRSMDARQRQDLLYFWTSSPALPASAHGFQPMPTITIRPPDDQHLPTANTCISRLYLPLYSSKQILREKLLQAIQTKGFGFV 3803

HSP 3 Score: 144.821 bits (364), Expect = 4.718e-30
Identity = 115/365 (31.51%), Postives = 167/365 (45.75%), Query Frame = 2

Query: 7247 PNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLXXXXXXXXXXXLNSLRPTIGSECGDSILDEDTNC-PTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQLPLHMGFS---SRWADRLL----DNNIIFSG------VPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRR 8299
            P  +S  ++  ++R DFL Y++S+MR++++EH D  P +++  ++ H AY+VDA LYL +  F M           PSG         +  HL+                              S+  ED  C  T   N++  N+  +        D    +    D+FF R+D      G G D   TPVSE+LPLA  PQ LQP     ++FG  RR     N +N            LP  +      S W+D L     +  I+  G         G++  RW  SLE  S  F  +VG E  S +V+   F+ KE RFRKEME+LRN  RRDL+L+V+RE   ++  TV QLN E+++R
Sbjct: 2962 PVGASVGTASGSSRQDFLTYLLSVMRSAANEHHDTAP-NIDITSHKHTAYIVDAFLYLFK-AFEMAW---------PSG---------LCHHLR------------------------------SLHQEDPLCIDTDNKNWRDNNAQTV--------DFPGPLAQRTDAFFRRSDSTLSLAGAGLDPVLTPVSEALPLAVYPQRLQPTSRRSDLFGTARRSS--ENILN------------LPTPVDVDPEHSTWSDMLKVSDSERPILMGGEFLDHTAHAGSVLARWCASLEAFSQKFSDDVGTESRSYMVELGRFTDKEARFRKEMERLRNATRRDLTLVVDREPRALLLGTVRQLNVEFNKR 3254

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. TrEMBL
Match: A0A0X3NHL3 (E3 ubiquitin-protein ligase UBR5 (Fragment) OS=Schistocephalus solidus OX=70667 GN=UBR5 PE=4 SV=1)

HSP 1 Score: 941.028 bits (2431), Expect = 0.000e+0
Identity = 694/2001 (34.68%), Postives = 1013/2001 (50.62%), Query Frame = 2

Query:   53 MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLXXXXXXXXXXXXXXXXXXENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAE---ENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDIFP---SIRLRRESLYSSMANDIESFADXXXXXXLDCQ-LRNSADPLPRTFPDGTCVSR--------NGNESPTFSPDDC--GKNESTPVKKNCLV-LGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQ-------------NSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQN-----LRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDR--------------TPKTEVKYNGQXXXXXXX-----XXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSIN-PASFDPLT------HAHMCPQLNTSFLYGLLGSS-NKSINIAEN----NQNTTDSINVTGSSSNYKMPTTWAEMXXXXXXXXXTCSDQSGPVKISPGTFKRKKQSVNTSGTGD----LVAEVNTEXXXXXXXXXXXXXXXCS----DTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFG---------NNNNACSE----TSINSTTPNS--------PDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPT------TLSPC--FGILGMAVENELIHLLVRK----------STSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNI--KSPIIPGSNSNSTN-DTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETEW--KLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSMNISSFPYRRWIDMGRPINDVNQFN----YSRSNDRQASSVRFT----------VMXXXXXXXXXILTGDSNSGWLLPPIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLA--LSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPM--------------------------PEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDG-INPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHP-----------LTMKPPTQT--------------KVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYS 5494
            MS  F FV   S +  +   +Q++L + LK  S+Q+K+DGV     L+ L Q  I E V+G + +AFRL+DGRVCR  + ++ +     +EK + R S    D       ++ S+RS+                       G  A   S R+ L   + R+         A  ++F+REMQRQGIY AR   + I A++VPE LIEQCQTVLQGKSRQLI+RELQRTNLDVNMAVNNLLSRDDEA+    +G   AP   E+ +D    L           + +   G+T+++     S RLR E L S    D  S++DRRKRRRLD      SAD            SR        + ++ P  + +D     N   P K    V LG  LEFW     D        F  IA +YSEL+ +T+  +LHQW+W  +EP+      SN++  Q             ++++   +    +  +  + H R  SL + GEKI+ LSAC +RA+V+TASG +A+++D+ +  + Q   +S  +    +      R EHP  +F ELK ETI +++T+ L+S V+C SGN+YWWGV P   R+  +++ R++              T  +    N +    +        A  +    + PG  VCMKNAP+FHAGA+GFT++ G+PK+G LLEDAWK+ D+CRF V+    L +   +   + +QS    +S D ++      HA  CP    ++   +  +S + S  +A+        T DS  V G  S+  +     EMPPPPSPASSTCSDQSGP+K+SPGTFKRKK    +S  G+     VA  ++E+   +++         S     TEK +     T       H   LT     N S         EE EDWCL DV+F+EDGRTQPVGV+LKVDG+IAAVKFLK+ +RAC+A NC  SP+  +           ++  AC +    T +N +   S        PDP++WLNDCRLL+K++L+VVK   + RVPD VQ  P+ IPT  FL +K +      T + C    ++ +A EN  IH +V +           +  K +EY + +L  K +SSHRL   + G     P+P          Y +L     +     RP+ LRD  G V+P L           S  EP   P WLDLP ++C    +++ +  +    S   P   +  +N   +K +KS+  R+L GV+V+   +LM +I+R +D+KV   + + A  +     VQ ++ E  DG RNI+H+AV MC P SN E EW  +L +IL  +S+    N  + +  Q  +W+L      +S P    +++G   +  +       + RS+    ++   T          V S      +   T   ++ W LPP+  D+  +R  SYRI+ +++  P +  +L  LLS    DG TPFM ++  + Y +A FLLD ++DL +++  S   S+   +  +  +FPP           SS  +D+PL +LC ND CSFTWTGP+HIR DIFECRTCGL +SLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC C++LI+G  S R  L ++LL+ TDL  LPN R EHL+++L K+V+RQ RE KQ R S RR       +          ++  +      P    P+                          PE+ LEP  F  +AL+ VL +  +  +LL                      DG  +P  D++ F+  QS + QLD+FVFTL+ K     +  LL+TL+  L+   S P           + ++ P+                  +   AR +RSVARV+ ++ L +APD  +K+   RLS+       Q +PL++C+ +F +L  V+  EL  +A  +++PVR G L+P+A Y    Q ++A+   DQ+  S
Sbjct:   13 MSCPFVFVSKPSKDVNSHSQLQSDLVDCLKRISDQVKKDGVSAPEVLRPLFQSRIIESVIGPSHIAFRLEDGRVCRVAYFLRPDSIPTLEEKRKARSSDMRNDSHYNREVSSGSTRSS-----------------------GASAALRSMRSPL-GVLGRH---------ARGLSFLREMQRQGIYLARPISSQIPAADVPESLIEQCQTVLQGKSRQLIVRELQRTNLDVNMAVNNLLSRDDEADLGGSSGTVGAPSATEDWEDEAEDLFSIFEHPEGHLLFESETGVTDELLDRAFSPRLRGE-LGSDY--DYTSYSDRRKRRRLDAHSYVRSADTYGGRSTSSYIESRRFWRSIPGSSDDQPQRADEDIYDSANPQIPSKNRYYVYLGDKLEFWPPSTSD---TPGFVFTAIAALYSELLAVTSSGELHQWKWKSTEPYGFQACESNNSFSQRLTFPIFNDRPTLDTDVASGATATQTATVN-HRHPRAASLGINGEKIVSLSACITRASVVTASGAIASFMDDVLPALLQATASSSSSSNALSLRSAVARFEHPATRFLELKHETIRKVYTAPLISVVQCESGNVYWWGVYPSYMRQRTVDRLRNQKQPVSTNASSPIQSTGHSRTNVNSRSRHTSTGPPGTLTAQPEPARPVGPGDLVCMKNAPVFHAGAVGFTLVNGLPKVGVLLEDAWKLTDVCRFRVKSPSILTSLSLSSCLDPIQSARLQSSMDQVSQTESALHAFACPHAIAAWNNNIPSTSFDVSAALADGVPPAAPATADS-GVGGPGSSLSL-----EMPPPPSPASSTCSDQSGPIKVSPGTFKRKKVPSTSSDRGERGTTTVARASSEAEGRASSPVGGQLRGSSRRTTSTEKESTEFGGTRSATKRQHSS-LTNRAGGNSSES-------EELEDWCLNDVVFVEDGRTQPVGVLLKVDGNIAAVKFLKEQDRACLAANCTLSPVCMLINSITAGVPPPSSAAACGQQSQLTKLNPSATKSSAGASSLPPDPMTWLNDCRLLKKDDLMVVKPTGLQRVPDFVQHSPRKIPTS-FLSSKASGETGSGTTTACNRKKLISIAPENGRIHAIVERLLDNPASGPPPSDPKTLEYHVFTLNGKTVSSHRLPILSQG----CPRPA---------YDQLA----YTCPAERPLLLRDSAGVVFPFL-------PTPRSGQEPWVFPQWLDLPSIQCAALSWLSPSCLSAFGDSQANPSPGATDSNLKKNKEAKSRIPRILFGVIVVSETSLMQYIVRAEDQKVEEALRSLATSTTTK--VQSVVHELADGHRNILHMAVLMCAPQSNREAEWSDRLVSILANQSEGKFKNLELRNPGQ--SWNL----TPTSKPLFSLLNLGSSRSGASGLTMHDLFIRSSIEAVTTPAHTTSDQETQGDVVASQPAFPSAPPTTTAGSNFWYLPPVSTDDFTRRQASYRILRLLLRDPTLRPYLRQLLSSVTDDGMTPFMLAIQCKAYQVANFLLDFLVDLENIRPESQTTSQFSYSPLMKYLFPP-----------SSCLDDSPLFMLCYNDTCSFTWTGPNHIRLDIFECRTCGLMDSLCCCTECARVCHKGHDCRLKRTSPTAYCDCWEKCCCRSLILGSQSMRLSLFERLLRETDLVYLPNGRGEHLMVYLTKSVERQCREQKQYRPSRRRLGPITSRSVIAAAAAAAVTTTPTGANADAPTSASPLSGRTQSGGVTSADVTGRGNGGASSDEPEHDLEPPTFCRDALELVLESKSAAASLLC--------------------GDGPPSPSKDEQPFMAIQSGASQLDEFVFTLLCKCPPELLHRLLSTLSTSLEEHLSAPRREKNLLRFLRIGLQQPSSESTSVDHSDSSSSFLACRHGIARFVRSVARVYTSIVLGLAPDHYKKKP--RLSS-------QSQPLELCRLVFLHLAPVACVELSLLAVGLLSPVRTGGLRPSAIYTLTSQTNEAIHAFDQVITS 1886

HSP 2 Score: 369.392 bits (947), Expect = 4.460e-98
Identity = 186/349 (53.30%), Postives = 241/349 (69.05%), Query Frame = 2

Query: 10109 PEQTPLFWQPGHPGFYCPRRVNLN---DNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGN--GNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSC---------------TISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            PE+ PLFWQPG  GFY PR V+ +   D+     R  IYR +GRVIG+ +L NET PL+  RHVLKYILG P+ WHDFAFF+S +YE LRQL+     A+  G +    D +L+YNL F+++   EEGG+  G S            L+P G+ +DV+S N++++VK+Y   +M  ++   L+ I+ GV+DVLP +AL+GL+ EDLRLLLNG  +INV+ L+ YT+FLDES                 T+ N+ ++V + K+WFW VV + ++ QRQ+LLYFWTSSPALPAS  GFQPMPTITIRP DD HLPTANTCISRLY+PLYS+K ILREKLLQAI+TK FGFV
Sbjct: 3478 PERAPLFWQPGLGGFYSPRAVSQSPSIDSAALQCRYTIYRCIGRVIGLCLLTNETCPLRFNRHVLKYILGRPLCWHDFAFFDSTVYEGLRQLLLYTTPARPEGTS----DSILDYNLTFSLLAAPEEGGSVRGPSAQHP--------LVPGGDKIDVNSVNIYEFVKRYAEFKMREVINEPLEHIRLGVFDVLPHNALDGLTSEDLRLLLNGVSDINVDTLVGYTTFLDESGASAFIALSEGTAGSGVTVPNAADRVARLKRWFWNVVRSMDARQRQDLLYFWTSSPALPASAHGFQPMPTITIRPPDDQHLPTANTCISRLYLPLYSSKQILREKLLQAIQTKGFGFV 3814

HSP 3 Score: 144.436 bits (363), Expect = 5.630e-30
Identity = 115/365 (31.51%), Postives = 167/365 (45.75%), Query Frame = 2

Query: 7247 PNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLXXXXXXXXXXXLNSLRPTIGSECGDSILDEDTNC-PTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQLPLHMGFS---SRWADRLL----DNNIIFSG------VPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRR 8299
            P  +S  ++  ++R DFL Y++S+MR++++EH D  P +++  ++ H AY+VDA LYL +  F M           PSG         +  HL+                              S+  ED  C  T   N++  N+  +        D    +    D+FF R+D      G G D   TPVSE+LPLA  PQ LQP     ++FG  RR     N +N            LP  +      S W+D L     +  I+  G         G++  RW  SLE  S  F  +VG E  S +V+   F+ KE RFRKEME+LRN  RRDL+L+V+RE   ++  TV QLN E+++R
Sbjct: 2935 PVGASVGTASGSSRQDFLTYLLSVMRSAANEHHDTAP-NIDITSHKHTAYIVDAFLYLFK-AFEMAW---------PSG---------LCHHLR------------------------------SLHQEDPLCIDTDNKNWRDNNAQTV--------DFPGPLAQRTDAFFRRSDSTLSLAGAGLDPVLTPVSEALPLAVYPQRLQPTSRRSDLFGTARRSS--ENILN------------LPTPVDVDPEHSTWSDMLKVSDSERPILMGGEFLDHTAHAGSVLARWCASLEAFSQKFSDDVGTESRSYMVELGRFTDKEARFRKEMERLRNATRRDLTLVVDREPRALLLGTVRQLNVEFNKR 3227

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. TrEMBL
Match: A0A0X3NNM2 (Uncharacterized protein (Fragment) OS=Schistocephalus solidus OX=70667 GN=TR160145 PE=4 SV=1)

HSP 1 Score: 941.028 bits (2431), Expect = 0.000e+0
Identity = 694/2001 (34.68%), Postives = 1013/2001 (50.62%), Query Frame = 2

Query:   53 MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLXXXXXXXXXXXXXXXXXXENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAE---ENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDIFP---SIRLRRESLYSSMANDIESFADXXXXXXLDCQ-LRNSADPLPRTFPDGTCVSR--------NGNESPTFSPDDC--GKNESTPVKKNCLV-LGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQ-------------NSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQN-----LRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDR--------------TPKTEVKYNGQXXXXXXX-----XXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSIN-PASFDPLT------HAHMCPQLNTSFLYGLLGSS-NKSINIAEN----NQNTTDSINVTGSSSNYKMPTTWAEMXXXXXXXXXTCSDQSGPVKISPGTFKRKKQSVNTSGTGD----LVAEVNTEXXXXXXXXXXXXXXXCS----DTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFG---------NNNNACSE----TSINSTTPNS--------PDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPT------TLSPC--FGILGMAVENELIHLLVRK----------STSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNI--KSPIIPGSNSNSTN-DTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETEW--KLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSMNISSFPYRRWIDMGRPINDVNQFN----YSRSNDRQASSVRFT----------VMXXXXXXXXXILTGDSNSGWLLPPIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLA--LSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPM--------------------------PEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDG-INPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHP-----------LTMKPPTQT--------------KVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYS 5494
            MS  F FV   S +  +   +Q++L + LK  S+Q+K+DGV     L+ L Q  I E V+G + +AFRL+DGRVCR  + ++ +     +EK + R S    D       ++ S+RS+                       G  A   S R+ L   + R+         A  ++F+REMQRQGIY AR   + I A++VPE LIEQCQTVLQGKSRQLI+RELQRTNLDVNMAVNNLLSRDDEA+    +G   AP   E+ +D    L           + +   G+T+++     S RLR E L S    D  S++DRRKRRRLD      SAD            SR        + ++ P  + +D     N   P K    V LG  LEFW     D        F  IA +YSEL+ +T+  +LHQW+W  +EP+      SN++  Q             ++++   +    +  +  + H R  SL + GEKI+ LSAC +RA+V+TASG +A+++D+ +  + Q   +S  +    +      R EHP  +F ELK ETI +++T+ L+S V+C SGN+YWWGV P   R+  +++ R++              T  +    N +    +        A  +    + PG  VCMKNAP+FHAGA+GFT++ G+PK+G LLEDAWK+ D+CRF V+    L +   +   + +QS    +S D ++      HA  CP    ++   +  +S + S  +A+        T DS  V G  S+  +     EMPPPPSPASSTCSDQSGP+K+SPGTFKRKK    +S  G+     VA  ++E+   +++         S     TEK +     T       H   LT     N S         EE EDWCL DV+F+EDGRTQPVGV+LKVDG+IAAVKFLK+ +RAC+A NC  SP+  +           ++  AC +    T +N +   S        PDP++WLNDCRLL+K++L+VVK   + RVPD VQ  P+ IPT  FL +K +      T + C    ++ +A EN  IH +V +           +  K +EY + +L  K +SSHRL   + G     P+P          Y +L     +     RP+ LRD  G V+P L           S  EP   P WLDLP ++C    +++ +  +    S   P   +  +N   +K +KS+  R+L GV+V+   +LM +I+R +D+KV   + + A  +     VQ ++ E  DG RNI+H+AV MC P SN E EW  +L +IL  +S+    N  + +  Q  +W+L      +S P    +++G   +  +       + RS+    ++   T          V S      +   T   ++ W LPP+  D+  +R  SYRI+ +++  P +  +L  LLS    DG TPFM ++  + Y +A FLLD ++DL +++  S   S+   +  +  +FPP           SS  +D+PL +LC ND CSFTWTGP+HIR DIFECRTCGL +SLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC C++LI+G  S R  L ++LL+ TDL  LPN R EHL+++L K+V+RQ RE KQ R S RR       +          ++  +      P    P+                          PE+ LEP  F  +AL+ VL +  +  +LL                      DG  +P  D++ F+  QS + QLD+FVFTL+ K     +  LL+TL+  L+   S P           + ++ P+                  +   AR +RSVARV+ ++ L +APD  +K+   RLS+       Q +PL++C+ +F +L  V+  EL  +A  +++PVR G L+P+A Y    Q ++A+   DQ+  S
Sbjct:   13 MSCPFVFVSKPSKDVNSHSQLQSDLVDCLKRISDQVKKDGVSAPEVLRPLFQSRIIESVIGPSHIAFRLEDGRVCRVAYFLRPDSIPTLEEKRKARSSDMRNDSHYNREVSSGSTRSS-----------------------GASAALRSMRSPL-GVLGRH---------ARGLSFLREMQRQGIYLARPISSQIPAADVPESLIEQCQTVLQGKSRQLIVRELQRTNLDVNMAVNNLLSRDDEADLGGSSGTVGAPSATEDWEDEAEDLFSIFEHPEGHLLFESETGVTDELLDRAFSPRLRGE-LGSDY--DYTSYSDRRKRRRLDAHSYVRSADTYGGRSTSSYIESRRFWRSIPGSSDDQPQRADEDIYDSANPQIPSKNRYYVYLGDKLEFWPPSTSD---TPGFVFTAIAALYSELLAVTSSGELHQWKWKSTEPYGFQACESNNSFSQRLTFPIFNDRPTLDTDVASGATATQTATVN-HRHPRAASLGINGEKIVSLSACITRASVVTASGAIASFMDDVLPALLQATASSSSSSNALSLRSAVARFEHPATRFLELKHETIRKVYTAPLISVVQCESGNVYWWGVYPSYMRQRTVDRLRNQKQPVSTNASSPIQSTGHSRTNVNSRSRHTSTGPPGTLTAQPEPARPVGPGDLVCMKNAPVFHAGAVGFTLVNGLPKVGVLLEDAWKLTDVCRFRVKSPSILTSLSLSSCLDPIQSARLQSSMDQVSQTESALHAFACPHAIAAWNNNIPSTSFDVSAALADGVPPAAPATADS-GVGGPGSSLSL-----EMPPPPSPASSTCSDQSGPIKVSPGTFKRKKVPSTSSDRGERGTTTVARASSEAEGRASSPVGGQLRGSSRRTTSTEKESTEFGGTRSATKRQHSS-LTNRAGGNSSES-------EELEDWCLNDVVFVEDGRTQPVGVLLKVDGNIAAVKFLKEQDRACLAANCTLSPVCMLINSITAGVPPPSSAAACGQQSQLTKLNPSATKSSAGASSLPPDPMTWLNDCRLLKKDDLMVVKPTGLQRVPDFVQHSPRKIPTS-FLSSKASGETGSGTTTACNRKKLISIAPENGRIHAIVERLLDNPASGPPPSDPKTLEYHVFTLNGKTVSSHRLPILSQG----CPRPA---------YDQLA----YTCPAERPLLLRDSAGVVFPFL-------PTPRSGQEPWVFPQWLDLPSIQCAALSWLSPSCLSAFGDSQANPSPGATDSNLKKNKEAKSRIPRILFGVIVVSETSLMQYIVRAEDQKVEEALRSLATSTTTK--VQSVVHELADGHRNILHMAVLMCAPQSNREAEWSDRLVSILANQSEGKFKNLELRNPGQ--SWNL----TPTSKPLFSLLNLGSSRSGASGLTMHDLFIRSSIEAVTTPAHTTSDQETQGDVVASQPAFPSAPPTTTAGSNFWYLPPVSTDDFTRRQASYRILRLLLRDPTLRPYLRQLLSSVTDDGMTPFMLAIQCKAYQVANFLLDFLVDLENIRPESQTTSQFSYSPLMKYLFPP-----------SSCLDDSPLFMLCYNDTCSFTWTGPNHIRLDIFECRTCGLMDSLCCCTECARVCHKGHDCRLKRTSPTAYCDCWEKCCCRSLILGSQSMRLSLFERLLRETDLVYLPNGRGEHLMVYLTKSVERQCREQKQYRPSRRRLGPITSRSVIAAAAAAAVTTTPTGANADAPTSASPLSGRTQSGGVTSADVTGRGNGGASSDEPEHDLEPPTFCRDALELVLESKSAAASLLC--------------------GDGPPSPSKDEQPFMAIQSGASQLDEFVFTLLCKCPPELLHRLLSTLSTSLEEHLSAPRREKNLLRFLRIGLQQPSSESTSVDHSDSSSSFLACRHGIARFVRSVARVYTSIVLGLAPDHYKKKP--RLSS-------QSQPLELCRLVFLHLAPVACVELSLLAVGLLSPVRTGGLRPSAIYTLTSQTNEAIHAFDQVITS 1886

HSP 2 Score: 369.392 bits (947), Expect = 5.132e-98
Identity = 186/349 (53.30%), Postives = 241/349 (69.05%), Query Frame = 2

Query: 10109 PEQTPLFWQPGHPGFYCPRRVNLN---DNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGN--GNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSC---------------TISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            PE+ PLFWQPG  GFY PR V+ +   D+     R  IYR +GRVIG+ +L NET PL+  RHVLKYILG P+ WHDFAFF+S +YE LRQL+     A+  G +    D +L+YNL F+++   EEGG+  G S            L+P G+ +DV+S N++++VK+Y   +M  ++   L+ I+ GV+DVLP +AL+GL+ EDLRLLLNG  +INV+ L+ YT+FLDES                 T+ N+ ++V + K+WFW VV + ++ QRQ+LLYFWTSSPALPAS  GFQPMPTITIRP DD HLPTANTCISRLY+PLYS+K ILREKLLQAI+TK FGFV
Sbjct: 3505 PERAPLFWQPGLGGFYSPRAVSQSPSIDSAALQCRYTIYRCIGRVIGLCLLTNETCPLRFNRHVLKYILGRPLCWHDFAFFDSTVYEGLRQLLLYTTPARPEGTS----DSILDYNLTFSLLAAPEEGGSVRGPSAQHP--------LVPGGDKIDVNSVNIYEFVKRYAEFKMREVINEPLEHIRLGVFDVLPHNALDGLTSEDLRLLLNGVSDINVDTLVGYTTFLDESGASAFIALSEGTAGSGVTVPNAADRVARLKRWFWNVVRSMDARQRQDLLYFWTSSPALPASAHGFQPMPTITIRPPDDQHLPTANTCISRLYLPLYSSKQILREKLLQAIQTKGFGFV 3841

HSP 3 Score: 144.436 bits (363), Expect = 5.638e-30
Identity = 114/363 (31.40%), Postives = 168/363 (46.28%), Query Frame = 2

Query: 7247 PNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLXXXXXXXXXXXLNSLRPTIGSECGDSILDEDTNC-PTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQL-PLHMGFSSRWADRLL----DNNIIFSG------VPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRR 8299
            P  +S  ++  ++R DFL Y++S+MR++++EH D  P +++  ++ H AY+VDA LYL +  F M           PSG         +  HL+                              S+  ED  C  T   N++  N+  +        D    +    D+FF R+D      G G D   TPVSE+LPLA  PQ LQP     ++FG  RR        +++N         + P H    S W+D L     +  I+  G         G++  RW  SLE  S  F  +VG E  S +V+   F+ KE RFRKEME+LRN  RRDL+L+V+RE   ++  TV QLN E+++R
Sbjct: 2962 PVGASVGTASGSSRQDFLTYLLSVMRSAANEHHDTAP-NIDITSHKHTAYIVDAFLYLFK-AFEMAW---------PSG---------LCHHLR------------------------------SLHQEDPLCIDTDNKNWRDNNAQTV--------DFPGPLAQRTDAFFRRSDSTLSLAGAGLDPVLTPVSEALPLAVYPQRLQPTSRRSDLFGTARR--------SSENILNLPTPVDVDPEH----STWSDMLKVSDSERPILMGGEFLDHTAHAGSVLARWCASLEAFSQKFSDDVGTESRSYMVELGRFTDKEARFRKEMERLRNATRRDLTLVVDREPRALLLGTVRQLNVEFNKR 3254

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. TrEMBL
Match: A0A5K3FGH2 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 906.36 bits (2341), Expect = 0.000e+0
Identity = 665/1935 (34.37%), Postives = 956/1935 (49.41%), Query Frame = 2

Query:   53 MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLXXXXXXXXXXXXXXXXXXENSHGYIAQANSARNSLPHRIARYQMLSSSHT----SAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDIF---PSIRLRRE-SL-YSSMANDIESFADXXXXXXLDCQ--LRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKN------ESTPVKKNC---LVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQN---LRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRD-----------------RTPKTEVKYNGQXXXXXXXXXXXXXXX-XIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCPQLNTSFLYGLLGSSNKSINIAENNQNTTDSINVTGSSSNYKMPTTWAEMXXXXXXXXXTCSDQSGPVKISPGTFKRKKQSVNTSGTGDLVAEVNTEXXXXXXXXXXXXXXXCSDTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTT--PNSP-DPISWLNDCRLLRKEELVVVKQP----LVSRVPDIVQKHPKCIPTEVFLEAKPTT---------LSPCFGILGMAVENELIHLLVRKSTSS-----KCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPI-------IPGSNSNSTNDTHKNSKSKFNR-------LLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLS--NVETEWKLSNILNYRSKKS----------STNTNVEDLSQRSNWSLEHSMNISSFPYRR-----WIDMGRPINDVNQFNYSRSNDRQASSVRFTVMXXXXXXXXXILTGDSNSGWLLPPIH--LDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDL----CDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSV---LNARHGNNVNFTASSHVSLLEPHHPAYEPPM-----PEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMK----------PPTQTKV----KTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYS 5494
            MS  F FV  Q  +G +   +Q +L+E LK  S+QIK+DGVY    L+ L +  I E VVG   +AFRLQDGRVCR +++++ +K     +K + R S S  + +                                     Y   ANS    +P      + L +  +    SA  ++  REMQRQGIY AR   + I AS+VPE+LIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEA+    +      E+ +D    L           + DG  G T+D+     S R RRE S+ Y     D  ++ DRRKRRRLD    LRNS       +   +  SR    S     DD G        E+T   KN    + LG NLEFW     ++ +     F+ IA +Y+EL+ + +  +LHQW+W  SEP++    +S    L + +  G ++ N       + H R  SL +  EK++ LS C +RA+++TA+G +A+W+DE +  + Q   ++           +R+EHP M F ELK ET+  + T+ L++ V+C SG ++WWGV+P   R+   EK +                   T +  V  +G        +        ++ PG  VCMKNAP+FHAGAIGFT++ GVPK+G LLEDAWK+ D+CRF V+   S +       P    +I  A+     HA  CP       Y    ++ ++    E +    DS  +              EMPPPPSPASSTCSDQSGPVK+SPGTFKRKK     S + D      + S   S +  +    +C+ ++K  +   + D                             EE EDWCL +V+F+EDGRTQPVGV+LKVDG+IAAVKFLK+ +RAC+A  C  +P+         +  + S  S+   P +P DP+SWLNDCRLL+K++L++VKQP    L  RVPD VQ  P+ +P      +              +P   I+ +A EN  +H +V +  +S     + +EY + +L  K +SS RL             P L  +P     S   + +       RP+ +RD NG V+P L          S  F     P WL LPPV+C    +++    +   P+        P   + S  D +  S S   R       +L+GV+V+   +L+ HILR D+ KV   + +   G+  D   Q ++SE  DG R+++H+AV MC P S    E   +L  IL   S  S          +T             SL   +N+S+    R      +  G  ++D+   +   +    AS+        ++ +    L G S     LPP+    DE  +R  S+RI+  ++ HP +   +  LL+  + DG TPFM +V  + Y +A FLLD + DL    CD         +    +  I+PP+              +D+PL  LC ND CSFTWTGP+HIRQDIFECRTCGL +SLCCC+ECARVCHKGHDC LK+TSPTAYCDCWEKCRC++L++G  ++R  L ++LL  TDL  LPNR  EHL+++L + V+RQ RE KQ ++S RR        L +   + V        S L          +     PE+ LEP  F+ +AL+ VL + P+  +LL     +       +  D   ++ G +        +  QS + QLD FVFTL+ K     +  L+NTL   L +       +K          P   T      +   AR IRSVARV+ +L L++ PD  +++  +RL++ V       +PL++ + +F +L  V+L EL R+A +++APVR G L+ TA +    Q S+A+   DQ+  +
Sbjct:    1 MSCPFFFVSRQPKDGCSQVQVQTDLHESLKNISDQIKKDGVYVPEVLRPLLRCTIVETVVGPTHIAFRLQDGRVCRVSYSLRADKLASNNDKRRGRSSDSRSESL-------------------------------------YNRDANSGSIRVPGASVALRTLRTPMSVLGRSARSLSLFREMQRQGIYLARPLSSQIPASDVPENLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEADLGASSGTVSIGEDWEDEAEDLFSLFEHPERHLLLDGESGFTDDLIDRPSSPRFRRELSIDYDRSLGDHAAYTDRRKRRRLDTHAYLRNS-----EAYSGRSAESRRFWRSVGLPSDDKGIRQDEDAFETTNTGKNNENNVQLGDNLEFWP---TNSAESVGCHFVSIAALYTELVAVNSQGELHQWKWQSSEPFNPHSSNSPPFNLMDQSESGAALVN-------HRHPRASSLGIAHEKVVSLSGCITRASIMTATGAIASWMDEVLPCLLQSAASAPAAAAAATSALMRLEHPAMHFGELKAETVTRVLTAPLITVVQCASGAVFWWGVLPSYIRQRNAEKQKHPISPVTSTSTAANTSITSTTRHRVTSSGSDVGSKTTSTTATAATFSLGPGDLVCMKNAPVFHAGAIGFTLVNGVPKVGVLLEDAWKLTDVCRFRVK-SPSAIGSGTTKNPLQSATITIATPSEAVHALTCP-------YAQAAAAAQAAAQTEPDPPPVDSGAL--------------EMPPPPSPASSTCSDQSGPVKVSPGTFKRKKAP---STSSDGGGGGGSASAASSVSRRQVESDQCTKSQKQTSKASHHD-----------------------------EEIEDWCLNEVVFVEDGRTQPVGVLLKVDGAIAAVKFLKEQDRACLAARCPAAPVCLFINQITKSTGQKSSTSSASLPLTPHDPMSWLNDCRLLKKDDLMLVKQPIGGGLPQRVPDFVQHSPRNVPFSFLGNSTAAAKQNHETSNVAAPRKRIIALAPENCRLHAIVDRMLASEGGQLRGLEYHVFTLNGKTVSSRRL-------------PALSKAPPSDGDSSFYSHLTLTCPAERPLLVRDSNGVVFPFL--PPSRPGQESWVF-----PSWLGLPPVQCAALAWISPPARHASVPLRAQRDGDAPAPPAVSRPDKNSVSASSSARQPHPGPRILLGVVVIAETSLLQHILRADETKVEETLRSLN-GAPPD-RAQVVLSEMADGHRSVLHMAVLMCAPTSRETPELAQRLEGILKQDSASSSSAAADGSGWTTIAPSSPPPPPPPRSLHSLLNLSATSGSRSAAAGGVSSGLTVHDLFIRSPLEAAGAAASTAPTIPAGGASDAAPPSLGGGSGHFCHLPPLSGTTDEVSRRLASHRILRALLLHPRLRPFMSRLLAGLSDDGLTPFMLAVQCKAYQVANFLLDYLCDLEGIRCDGSEEVNHQFRYSRLMPYIYPPSAR-----------LDDSPLFTLCYNDNCSFTWTGPNHIRQDIFECRTCGLMDSLCCCSECARVCHKGHDCRLKRTSPTAYCDCWEKCRCRSLVLGHQASRLSLFQRLLLFTDLVYLPNRSNEHLMVYLTRCVERQTREQKQYKSSRRRGGGGERVSLASNLASRVALATGEAASSLTRGGGGGGGNVTSLDEPEHDLEPPTFSRDALELVLDSRPAAASLLCDSKSTFASEPFTRFADRKGKSAGYS-------VMAIQSGTSQLDDFVFTLLCKCPPEFLVRLVNTLACSLSDHLMADRGLKRLLALCLHDGPVDNTDAYFYCQRGVARFIRSVARVYTSLVLELTPDHYKRK--SRLTSQV-------QPLELSRFVFFHLAPVALPELTRLAVNVLAPVRTGALRSTALFNLTSQQSEAIHGFDQVLAA 1780

HSP 2 Score: 147.902 bits (372), Expect = 4.900e-31
Identity = 93/282 (32.98%), Postives = 134/282 (47.52%), Query Frame = 2

Query: 7745 DSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEID-------RNTINNQNFCGRSNEGQLPLHMGFSSRWADRLLDNNIIFSGV------PVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRR---------------------------------NSTNTQNP---------LMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLS 8425
            D++F R+       G G D   +PV+++LPLA  P  LQP     E+FG+ R    D       R    +      ++ G+   +      + D  +   I++ G         G + +RW  +L+  + +F ++VG E  S +V+   F  KE RFRKEME+LRN  RRDL+L V RE N ++  TV QLN E+S R                                 ++ ++Q P         L CHR KV F DEPGEG+GVARSF+T F+EAVL+
Sbjct: 2704 DAYFRRSASTLSLAGAGLDPVLSPVADALPLAVAPHQLQPNSRRSELFGITRDIHSDVFDLLPSRPHEKDGGHNDEASSGKAVHYSRIGKLFKDSSIGRQIVWGGEFLDVCGHAGLVLSRWCTALDAFTRAFPEDVGAEHRSYMVELARFPEKEARFRKEMERLRNASRRDLTLEVEREPNALLISTVRQLNAEFSHRFNMSPATPFFVTKGAPNQSAARSMRASMGPSTSSAASSQPPNLSPGGAAILACHRLKVTFKDEPGEGSGVARSFITAFSEAVLT 2985

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. TrEMBL
Match: A0A5K3FCE0 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 905.59 bits (2339), Expect = 0.000e+0
Identity = 665/1933 (34.40%), Postives = 955/1933 (49.41%), Query Frame = 2

Query:   53 MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLXXXXXXXXXXXXXXXXXXENSHGYIAQANSARNSLPHRIARYQMLSSSHT----SAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDIF---PSIRLRRE-SL-YSSMANDIESFADXXXXXXLDCQ--LRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKN------ESTPVKKNC---LVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQN---LRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRD-----------------RTPKTEVKYNGQXXXXXXXXXXXXXXX-XIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCPQLNTSFLYGLLGSSNKSINIAENNQNTTDSINVTGSSSNYKMPTTWAEMXXXXXXXXXTCSDQSGPVKISPGTFKRKKQSVNTSGTGDLVAEVNTEXXXXXXXXXXXXXXXCSDTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTT--PNSP-DPISWLNDCRLLRKEELVVVKQP----LVSRVPDIVQKHPKCIPTEVFLEAKPTT---------LSPCFGILGMAVENELIHLLVRKSTSS-----KCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPI-------IPGSNSNSTNDTHKNSKSKFNR-------LLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLS--NVETEWKLSNILNYRSKKS----------STNTNVEDLSQRSNWSLEHSMNISSFPYRR-----WIDMGRPINDVNQFNYSRSNDRQASSVRFTVMXXXXXXXXXILTGDSNSGWLLPPIH--LDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDL----CDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSV---LNARHGNNVNFTASSHVSLLEPHHPAYEPPM-----PEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMK----------PPTQTKV----KTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            MS  F FV  Q  +G +   +Q +L+E LK  S+QIK+DGVY    L+ L +  I E VVG   +AFRLQDGRVCR +++++ +K     +K + R S S  + +                                     Y   ANS    +P      + L +  +    SA  ++  REMQRQGIY AR   + I AS+VPE+LIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEA+    +      E+ +D    L           + DG  G T+D+     S R RRE S+ Y     D  ++ DRRKRRRLD    LRNS       +   +  SR    S     DD G        E+T   KN    + LG NLEFW     ++ +     F+ IA +Y+EL+ + +  +LHQW+W  SEP++    +S    L + +  G ++ N       + H R  SL +  EK++ LS C +RA+++TA+G +A+W+DE +  + Q   ++           +R+EHP M F ELK ET+  + T+ L++ V+C SG ++WWGV+P   R+   EK +                   T +  V  +G        +        ++ PG  VCMKNAP+FHAGAIGFT++ GVPK+G LLEDAWK+ D+CRF V+   S +       P    +I  A+     HA  CP       Y    ++ ++    E +    DS  +              EMPPPPSPASSTCSDQSGPVK+SPGTFKRKK     S + D      + S   S +  +    +C+ ++K  +   + D                             EE EDWCL +V+F+EDGRTQPVGV+LKVDG+IAAVKFLK+ +RAC+A  C  +P+         +  + S  S+   P +P DP+SWLNDCRLL+K++L++VKQP    L  RVPD VQ  P+ +P      +              +P   I+ +A EN  +H +V +  +S     + +EY + +L  K +SS RL             P L  +P     S   + +       RP+ +RD NG V+P L          S  F     P WL LPPV+C    +++    +   P+        P   + S  D +  S S   R       +L+GV+V+   +L+ HILR D+ KV   + +   G+  D   Q ++SE  DG R+++H+AV MC P S    E   +L  IL   S  S          +T             SL   +N+S+    R      +  G  ++D+   +   +    AS+        ++ +    L G S     LPP+    DE  +R  S+RI+  ++ HP +   +  LL+  + DG TPFM +V  + Y +A FLLD + DL    CD         +    +  I+PP+              +D+PL  LC ND CSFTWTGP+HIRQDIFECRTCGL +SLCCC+ECARVCHKGHDC LK+TSPTAYCDCWEKCRC++L++G  ++R  L ++LL  TDL  LPNR  EHL+++L + V+RQ RE KQ ++S RR        L +   + V        S L          +     PE+ LEP  F+ +AL+ VL + P+  +LL     +       +  D   ++ G +        +  QS + QLD FVFTL+ K     +  L+NTL   L +       +K          P   T      +   AR IRSVARV+ +L L++ PD  +++  +RL++ V       +PL++ + +F +L  V+L EL R+A +++APVR G L+ TA +    Q S+A+   DQ+ 
Sbjct:    1 MSCPFFFVSRQPKDGCSQVQVQTDLHESLKNISDQIKKDGVYVPEVLRPLLRCTIVETVVGPTHIAFRLQDGRVCRVSYSLRADKLASNNDKRRGRSSDSRSESL-------------------------------------YNRDANSGSIRVPGASVALRTLRTPMSVLGRSARSLSLFREMQRQGIYLARPLSSQIPASDVPENLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEADLGASSGTVSIGEDWEDEAEDLFSLFEHPERHLLLDGESGFTDDLIDRPSSPRFRRELSIDYDRSLGDHAAYTDRRKRRRLDTHAYLRNS-----EAYSGRSAESRRFWRSVGLPSDDKGIRQDEDAFETTNTGKNNENNVQLGDNLEFWP---TNSAESVGCHFVSIAALYTELVAVNSQGELHQWKWQSSEPFNPHSSNSPPFNLMDQSESGAALVN-------HRHPRASSLGIAHEKVVSLSGCITRASIMTATGAIASWMDEVLPCLLQSAASAPAAAAAATSALMRLEHPAMHFGELKAETVTRVLTAPLITVVQCASGAVFWWGVLPSYIRQRNAEKQKHPISPVTSTSTAANTSITSTTRHRVTSSGSDVGSKTTSTTATAATFSLGPGDLVCMKNAPVFHAGAIGFTLVNGVPKVGVLLEDAWKLTDVCRFRVK-SPSAIGSGTTKNPLQSATITIATPSEAVHALTCP-------YAQAAAAAQAAAQTEPDPPPVDSGAL--------------EMPPPPSPASSTCSDQSGPVKVSPGTFKRKKAP---STSSDGGGGGGSASAASSVSRRQVESDQCTKSQKQTSKASHHD-----------------------------EEIEDWCLNEVVFVEDGRTQPVGVLLKVDGAIAAVKFLKEQDRACLAARCPAAPVCLFINQITKSTGQKSSTSSASLPLTPHDPMSWLNDCRLLKKDDLMLVKQPIGGGLPQRVPDFVQHSPRNVPFSFLGNSTAAAKQNHETSNVAAPRKRIIALAPENCRLHAIVDRMLASEGGQLRGLEYHVFTLNGKTVSSRRL-------------PALSKAPPSDGDSSFYSHLTLTCPAERPLLVRDSNGVVFPFL--PPSRPGQESWVF-----PSWLGLPPVQCAALAWISPPARHASVPLRAQRDGDAPAPPAVSRPDKNSVSASSSARQPHPGPRILLGVVVIAETSLLQHILRADETKVEETLRSLN-GAPPDR-AQVVLSEMADGHRSVLHMAVLMCAPTSRETPELAQRLEGILKQDSASSSSAAADGSGWTTIAPSSPPPPPPPRSLHSLLNLSATSGSRSAAAGGVSSGLTVHDLFIRSPLEAAGAAASTAPTIPAGGASDAAPPSLGGGSGHFCHLPPLSGTTDEVSRRLASHRILRALLLHPRLRPFMSRLLAGLSDDGLTPFMLAVQCKAYQVANFLLDYLCDLEGIRCDGSEEVNHQFRYSRLMPYIYPPSAR-----------LDDSPLFTLCYNDNCSFTWTGPNHIRQDIFECRTCGLMDSLCCCSECARVCHKGHDCRLKRTSPTAYCDCWEKCRCRSLVLGHQASRLSLFQRLLLFTDLVYLPNRSNEHLMVYLTRCVERQTREQKQYKSSRRRGGGGERVSLASNLASRVALATGEAASSLTRGGGGGGGNVTSLDEPEHDLEPPTFSRDALELVLDSRPAAASLLCDSKSTFASEPFTRFADRKGKSAGYS-------VMAIQSGTSQLDDFVFTLLCKCPPEFLVRLVNTLACSLSDHLMADRGLKRLLALCLHDGPVDNTDAYFYCQRGVARFIRSVARVYTSLVLELTPDHYKRK--SRLTSQV-------QPLELSRFVFFHLAPVALPELTRLAVNVLAPVRTGALRSTALFNLTSQQSEAIHGFDQVL 1778

HSP 2 Score: 370.163 bits (949), Expect = 2.652e-98
Identity = 183/351 (52.14%), Postives = 242/351 (68.95%), Query Frame = 2

Query: 10115 QTPLFWQPGHPGFYCPRRVNL---NDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISN---------------------SQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            + PLFWQPG  GFY PR V+     D+ + Y R +IYR VGRVIG+ +L NET PL+  RHVLKYILG P+ WHDFAF+N+ +YE LRQL+      +  G      D + +YNL F+++   EEGG+  +      G     L P GE++DVDS  ++++VK+Y   +M  ++K  L+Q++ GV+D+LP +AL+GL+ EDLRLLLNG  +++V++L+SYT+FLDES C+ S+                     + E+V + K+WFW VV   ++ QRQ+LLYFWTSSPALPAS QGF PMPTI IRPADD HLPTANTCISRLY+PLYS+K +LREKLLQAIET+SFGFV
Sbjct: 3177 RAPLFWQPGLAGFYSPRAVSCAVPRDSPELYCRLSIYRCVGRVIGLCLLFNETCPLRFNRHVLKYILGRPLCWHDFAFYNTTVYEGLRQLLLYTTSTRPDG----ESDSIRDYNLTFSLMMAPEEGGSSGAS-----GPQQHPLAPGGEEIDVDSEKIYEFVKRYTEFKMWEVIKEPLEQLRLGVFDMLPTNALDGLTAEDLRLLLNGIWDVDVDLLVSYTTFLDESGCSSSSGVAGDGQPSGTDGADPASSPTATERVARLKRWFWHVVRGMDTRQRQDLLYFWTSSPALPASAQGFAPMPTIMIRPADDQHLPTANTCISRLYLPLYSSKQVLREKLLQAIETRSFGFV 3518

HSP 3 Score: 147.517 bits (371), Expect = 6.522e-31
Identity = 96/299 (32.11%), Postives = 140/299 (46.82%), Query Frame = 2

Query: 7694 PQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEID-------RNTINNQNFCGRSNEGQLPLHMGFSSRWADRLLDNNIIFSGV------PVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRR---------------------------------NSTNTQNP---------LMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLS 8425
            P++ H R    +     D++F R+       G G D   +PV+++LPLA  P  LQP     E+FG+ R    D       R    +      ++ G+   +      + D  +   I++ G         G + +RW  +L+  + +F ++VG E  S +V+   F  KE RFRKEME+LRN  RRDL+L V RE N ++  TV QLN E+S R                                 ++ ++Q P         L CHR KV F DEPGEG+GVARSF+T F+EAVL+
Sbjct: 2691 PRLFHGRPLAGR----NDAYFRRSASTLSLAGAGLDPVLSPVADALPLAVAPHQLQPNSRRSELFGITRDIHSDVFDLLPSRPHEKDGGHNDEASSGKAVHYSRIGKLFKDSSIGRQIVWGGEFLDVCGHAGLVLSRWCTALDAFTRAFPEDVGAEHRSYMVELARFPEKEARFRKEMERLRNASRRDLTLEVEREPNALLISTVRQLNAEFSHRFNMSPATPFFVTKGAPNQSAARSMRASMGPSTSSAASSQPPNLSPGGAAILACHRLKVTFKDEPGEGSGVARSFITAFSEAVLT 2985

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Cavefish
Match: ubr5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:ZFIN;Acc:ZDB-GENE-030131-6559])

HSP 1 Score: 333.954 bits (855), Expect = 5.448e-91
Identity = 198/502 (39.44%), Postives = 289/502 (57.57%), Query Frame = 2

Query: 3992 PIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQ-YVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTAS--SSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            P  ++ K++++N++ I+ ++ +   +  HL  LLS ++A G TPFM +VS R YP A+ +L+    +   +  +      + + + MI P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  +AR +LL +LL  T+L T PN R EH+LLFLV+TV RQ  EH Q R    R      N +  N                  A +  MP++ LEP  FA  AL+ VL +W +++ +++ G + +        + +SSR   + P  +++++LN QS + +LD F   LI K A   + +D LL TL KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  C+R+F+ LL  ++ EL  +A  +I PVR G+ +PTA +       DAV+  +++F
Sbjct:  819 PSVVESKDRKANAHLILKLMCDSVVLRPHLRELLSAKDARGMTPFMLAVSGRAYPAAITVLEAAQKIAKGEPGIGEKEDVNSVFMEMICPAGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKAARLDLLYRLLTTTNLVTSPNSRGEHILLFLVQTVARQSVEHCQYRPPRIREDR---NRKAAN------------------AEDSDMPDHDLEPPRFAQLALERVLQDWNALKCMIMFGSQEN-----KDPLSASSRIAHLLP--EEQMYLNQQSGTIRLDCFTHCLIVKCAPDITFIDTLLGTLVKELQNKYT------PGRREEAICVTRRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCRRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAVQGSEELF 1262

HSP 2 Score: 319.316 bits (817), Expect = 1.840e-86
Identity = 157/326 (48.16%), Postives = 217/326 (66.56%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL++ ++  +   +  A        +L F I   +EEG               + L+  G ++ V   NV++YV+KY   RM+ + +  L  ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + EK+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2242 APLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLIRHSQTGEAEAVFAA-------MDLAFAIDLCKEEGSG------------QVELLTGGANMPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2539

HSP 3 Score: 173.711 bits (439), Expect = 2.523e-42
Identity = 105/315 (33.33%), Postives = 157/315 (49.84%), Query Frame = 2

Query: 1166 LGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCP 2110
            LG  L++W +K          +F+ IA M+SEL+ I++  +L+QW+W + EP+ +          QN +I               +H R+  L L  EKI  LSA S RATV T + K+ATWVDET++ +                ++EH    F EL+ E I  L   +L +  + +S ++YWWGV+PF  RK  +EK R +  K +            ++A      NI  G+ VC++N P++HAGA+ F+V  GVPK+G LLE  W + D CRF +R  +SL +  ++      Q I   S   L    M P
Sbjct:  102 LGEELQWWPDK-------DGTRFVSIAAMFSELVAISSKGELYQWKWSEPEPYRNA---------QNPSI---------------HHPRVSFLGLANEKITLLSANSIRATVATETNKVATWVDETLSSV--------------ACKLEHGAQTFPELQGERIVSLHCCSLYTCAQLDS-SLYWWGVVPFSQRKKMLEKARAKNKKPK------------SSAGIASIPNITVGTQVCLRNNPLYHAGAVAFSVSAGVPKVGVLLESVWNMNDSCRFQLRSPESLKSMEKS---TKAQEIKTESKPELVKTEMGP 355

HSP 4 Score: 142.895 bits (359), Expect = 5.929e-33
Identity = 119/389 (30.59%), Postives = 176/389 (45.24%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYDGF-VQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF                             S  S  S  P   DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++  +  +   + L + GK    +H   TS   FLG++                 +N  IF A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+  +  G  ++ N       +P   SNST            +  + ++ +E QTLM H+LR D +     + +   AV  E +   +  ++  + DG RN++H  V++C P+SN
Sbjct:  378 KRRRSTPAPKEEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKF-------------------------PGTSSSVSSQSAAPTDSDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKA-------------EILAVNVDSKGVHAVLKTGSWVRYCIFDLAT-GKAEQENH-FPTSNLAFLGQSE----------------RNVAIFTAGQESPIILRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPIASLGMGVHSLAN-------LP---SNSTIK---------KKAAIIIMAVEKQTLMQHVLRCDYEACRQYLVSLEQAVLLEQNPHALDALLGHRCDGNRNLLHACVSVCFPVSN 681

HSP 5 Score: 137.887 bits (346), Expect = 1.852e-31
Identity = 70/138 (50.72%), Postives = 93/138 (67.39%), Query Frame = 2

Query: 8030 FSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRN   RDL+L V+R+R+ +I  T+ QLNT + RR +T    P+  HR KV F DEPGEG+GVARSF T  A+A LS + L
Sbjct: 1923 FMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNLQSRDLALEVDRDRDQLIQQTMRQLNTHFGRRCAT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNDKL 2057

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Cavefish
Match: hace1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:103021726])

HSP 1 Score: 100.523 bits (249), Expect = 2.544e-20
Identity = 79/306 (25.82%), Postives = 138/306 (45.10%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIG-MNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINV---EVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP-------ASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            N +R  G+++G+++   + + +   R   K+ILG+P+ + D +  + +  ++L+ ++               ++ + +  L  T            S +  V G M  + L P G  + V   N  +YV+     RM   ++PQ++    G +  +P   +      +L LLL+G  EI+V   +    YTS  D        ++E V    +WFW VV +    +R  LL F T S  +P           G Q   TI   P     LPT++TCI+ L +P Y +K +LR++LL A+   S+G+
Sbjct:  593 NYFRFAGQILGLALYHRQLVNIYFTRSFYKHILGIPVNYQDVSSIDPEYAKNLQWIL---------------DNDISDLGLELTF-----------SVETDVFGAMEEVALKPGGTSIQVTQENKAEYVQLVTELRMTRAIQPQINAFLQGFHTFIPPSLIQLFDEYELELLLSGMPEIDVLDWKRNTEYTSGYD--------TEEPVI---QWFWDVVESLTQEERVLLLQFVTGSSRVPHGGFAFIMGGSGLQKF-TIAAVPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLLVALHCGSYGY 860

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Cavefish
Match: hace1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:103021726])

HSP 1 Score: 100.138 bits (248), Expect = 3.277e-20
Identity = 79/306 (25.82%), Postives = 138/306 (45.10%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIG-MNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINV---EVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP-------ASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            N +R  G+++G+++   + + +   R   K+ILG+P+ + D +  + +  ++L+ ++               ++ + +  L  T            S +  V G M  + L P G  + V   N  +YV+     RM   ++PQ++    G +  +P   +      +L LLL+G  EI+V   +    YTS  D        ++E V    +WFW VV +    +R  LL F T S  +P           G Q   TI   P     LPT++TCI+ L +P Y +K +LR++LL A+   S+G+
Sbjct:  662 NYFRFAGQILGLALYHRQLVNIYFTRSFYKHILGIPVNYQDVSSIDPEYAKNLQWIL---------------DNDISDLGLELTF-----------SVETDVFGAMEEVALKPGGTSIQVTQENKAEYVQLVTELRMTRAIQPQINAFLQGFHTFIPPSLIQLFDEYELELLLSGMPEIDVLDWKRNTEYTSGYD--------TEEPVI---QWFWDVVESLTQEERVLLLQFVTGSSRVPHGGFAFIMGGSGLQKF-TIAAVPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLLVALHCGSYGY 929

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Cavefish
Match: hecw2a (E3 ubiquitin-protein ligase HECW2-like [Source:NCBI gene;Acc:103029563])

HSP 1 Score: 89.7373 bits (221), Expect = 6.903e-17
Identity = 82/313 (26.20%), Postives = 133/313 (42.49%), Query Frame = 2

Query: 10181 DNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVL---ISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQ-PMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAI-ETKSFGF 11092
            DN+ E+     +R  GR++G++++    +     R   K +L +P    D  F + + ++SL Q MK               D  +E  L+ T    EE  G           +    L P G  V V   N  +Y+++    R+   V  Q + +  G Y+V+    ++     +L L++ GT EI++        Y     ++   I           +WFW  V  FN+ QR  LL F T + ++P    AS +G   P      +      LP A+TC +RL +P Y +  +L EKLL A+ ET +FG 
Sbjct: 1211 DNHHEW-----FRFSGRILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSL-QWMK---------------DNDIEDMLDLTFTVNEEVFGQ----------ITERELKPGGAGVPVSEKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEIDLADWRNNTEYRGGYHDNHIVI-----------RWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYHSFSMLYEKLLTAVEETSTFGL 1481

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Cavefish
Match: smurf1 (SMAD specific E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:103027089])

HSP 1 Score: 87.4261 bits (215), Expect = 1.611e-16
Identity = 76/302 (25.17%), Postives = 134/302 (44.37%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMP--------TITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            +  VGR++G+++     +         K +LG PI   D    + +L++SL  ++    E  +  +        +E+N     +  E                    L PNG ++ V   N  +YV+ Y   R +  ++ Q   ++ G  +++P+H L     ++L L++ G  +I++    + T       C   ++        KWFWQ V +F+  +R  LL F T S  +P   QGF+ +         TI +  A+  +LP A+TC +R+ IP Y +   L EKLL A+E ++ GF 
Sbjct:  414 FHFVGRIMGLAVFHGHYINGGFTLPFYKQLLGKPIQLSDLETVDPELHKSLVWIL----ENDITSVLD--HTFCVEHNAFGKFLQHE--------------------LKPNGRNIPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDNKELELIIGGLGKIDLNDWKANTRL---KHCVADSN------IVKWFWQAVESFDEERRGRLLQFVTGSTRVPL--QGFKALQGSAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE-ETCGFA 677

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002570.1 (pep scaffold:Pmarinus_7.0:GL481077:241:22857:1 gene:ENSPMAG00000002321.1 transcript:ENSPMAT00000002570.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 330.487 bits (846), Expect = 8.815e-92
Identity = 200/499 (40.08%), Postives = 284/499 (56.91%), Query Frame = 2

Query: 4004 DEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIR-TSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTD---DEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            + K++++ ++ I+ ++     ++ ++  LLS ++A G TPFM +VS R YP A+ +L+         +V    ++    +SMI P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  +AR ELL +LL  TDL T PN R EHLLLFLV+TV RQ  EH Q R   GR   T       G   +  + +H  L E      E  MP++ LEP  FA  AL+ VL +W +V++++  G +        +N D S   +   P TD   ++V+L+ QS + +LD F   L+ K +   +   L T        K       P  + +      R +RSVAR+FV L ++MA   + K++++  SN V      P+P+  CKR+F+ LL +++ EL  +A  +I PVR G+ +PTA +A      DA++  ++IF
Sbjct:  600 EPKDRKATAHAILKLLCETSLLKFYMRELLSAKDARGMTPFMLAVSGRAYPAAITVLE-------TAFVLSTENRDDF-MSMICPTGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKAARLELLHRLLTTTDLVTRPNSRGEHLLLFLVQTVARQMVEHCQYRPPRGRDERTRKPAGADGKTSD--SETHHELWE----EMEADMPDHDLEPPRFAQQALERVLKDWNAVKSMITFGSQ--------ENKDPSVPAEYWGPTTDIGEEQVYLSQQSGTIRLDCFTHCLLVKCSDMGLLDTLLTTLVTELQNK-----YTPGRREEAVAVTRRFLRSVARIFVILSVEMA---SSKKKNHPRSNFV------PQPIGKCKRVFQALLPLAVEELCHVAESLIVPVRMGVARPTAPFALVSTSLDAMQGSEEIF 1051

HSP 2 Score: 135.191 bits (339), Expect = 1.833e-31
Identity = 116/378 (30.69%), Postives = 167/378 (44.18%), Query Frame = 2

Query: 2582 EEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYD-GFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETE 3697
            EE W LK+V+F+ED ++ PVG VLKVDG+  AV+F                      G N    S   +       PDP S L DCRLLR +EL VVK     +VPD  Q+ P+  C+P +               IL + V+ + +H ++R  T    + Y L  L   K    +   TS+   LG+                +  N  I++A +  P+ LRDGNGT+YPL      + + M      I  P WLDLPPVR +  G   + N       +P ++S     T            V V+ +E Q L+  +LR D +     +     ++  E D G V+ I  E+ DG RN++H  V+ C P SN E +
Sbjct:  150 EEQWNLKEVVFVEDVKSVPVGKVLKVDGAYVAVRFP---------------------GANGPVASAVVVPPAPGPDPDPTSLLQDCRLLRIDELQVVKSGGAPKVPDCFQRAPRKMCVPDKA-------------DILALNVDAKGVHTVLRSGT---WVRYCLFDLATCKPEQENNFPTSSAALLGQ----------------DEHNIAIYSAGQESPVILRDGNGTLYPL------ARDCMGG----IRDPDWLDLPPVRSLGVGLHALTN-------LPANSSIKKKAT------------VIVMAIEKQPLLTPVLRCDYEACRLALLGMEQSLLMELDAGEVENIPHERCDGNRNVLHACVSTCFPTSNKEAK 445

HSP 3 Score: 61.2326 bits (147), Expect = 6.053e-9
Identity = 23/43 (53.49%), Postives = 30/43 (69.77%), Query Frame = 2

Query: 1874 VCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSV 2002
            VCM+N P++ AGA+ F+V  GVPK+G L E  W + D CRF V
Sbjct:    1 VCMRNNPVYQAGAVAFSVSSGVPKVGVLQESVWNMNDCCRFRV 43

HSP 4 Score: 50.8322 bits (120), Expect = 8.503e-6
Identity = 35/134 (26.12%), Postives = 57/134 (42.54%), Query Frame = 2

Query: 7061 TLSQSEEEHVMIESSQQLGPIWIWICQSMDFLESQVCFANAFQRKHG-TYKARPVPTFEQVNTPNISSAPSSGDAN-----------RADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMR 7426
            TL   +  H+     + L   W W+   MD  E+Q+ + +A       ++ + P+   +              DA            R DFL Y +S+MRA  DEH D  P  L+  +  H+AY+  AL+Y ++
Sbjct: 1342 TLRFQDAVHLQKYVEEHLVLTWNWMVSVMDSTEAQLRYGSALASAGDPSHPSHPLHASQNPARRERERPNPRDDAALRGLESRRLSARGDFLTYALSLMRAHKDEHSDILPL-LDVCSLKHVAYVFQALIYWIK 1474

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002561.1 (pep scaffold:Pmarinus_7.0:GL481077:241:24166:1 gene:ENSPMAG00000002321.1 transcript:ENSPMAT00000002561.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 319.316 bits (817), Expect = 3.565e-88
Identity = 193/498 (38.76%), Postives = 276/498 (55.42%), Query Frame = 2

Query: 4010 KEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIM----DLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGI-NPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            K++++ ++ I+ ++     ++ ++  LLS ++A G TPFM +VS R YP A+ +L+  +      C+   +          +SMI P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  +AR ELL +LL  TDL T PN R EHLLLFLV+TV RQ  EH Q R    R   +   A                      A E  MP++ LEP  FA  AL+ VL +W +V++++  G +        +N D  S +  I + L +++V+L+ QS + +LD F   L+ K +   +   L T        K       P  + +      R +RSVAR+FV L ++MA   + K+++N +          P+P+  CKR+F+ LL +++ EL  +A  +I PVR G+ +PTA +A      DA++  ++IF
Sbjct:  556 KDRKATAHAILKLLCETSLLKFYMRELLSAKDARGMTPFMLAVSGRAYPAAITVLETAVLTRVRECNKNSLEKETENRDDFMSMICPTGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKAARLELLHRLLTTTDLVTRPNSRGEHLLLFLVQTVARQMVEHCQYRPPRGRDERTRKPAG---------------------ADEADMPDHDLEPPRFAQQALERVLKDWNAVKSMITFGSQ--------ENKDPLSASSRIAHLLAEEQVYLSQQSGTIRLDCFTHCLLVKCSDMGLLDTLLTTLVTELQNK-----YTPGRREEAVAVTRRFLRSVARIFVILSVEMA---SSKKKNNFV----------PQPIGKCKRVFQALLPLAVEELCHVAESLIVPVRMGVARPTAPFALVSTSLDAMQGSEEIF 995

HSP 2 Score: 135.961 bits (341), Expect = 1.063e-31
Identity = 116/378 (30.69%), Postives = 167/378 (44.18%), Query Frame = 2

Query: 2582 EEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYD-GFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETE 3697
            EE W LK+V+F+ED ++ PVG VLKVDG+  AV+F                      G N    S   +       PDP S L DCRLLR +EL VVK     +VPD  Q+ P+  C+P +               IL + V+ + +H ++R  T    + Y L  L   K    +   TS+   LG+                +  N  I++A +  P+ LRDGNGT+YPL      + + M      I  P WLDLPPVR +  G   + N       +P ++S     T            V V+ +E Q L+  +LR D +     +     ++  E D G V+ I  E+ DG RN++H  V+ C P SN E +
Sbjct:  115 EEQWNLKEVVFVEDVKSVPVGKVLKVDGAYVAVRFP---------------------GANGPVASAVVVPPAPGPDPDPTSLLQDCRLLRIDELQVVKSGGAPKVPDCFQRAPRKMCVPDKA-------------DILALNVDAKGVHTVLRSGT---WVRYCLFDLATCKPEQENNFPTSSAALLGQ----------------DEHNIAIYSAGQESPVILRDGNGTLYPL------ARDCMGG----IRDPDWLDLPPVRSLGVGLHALTN-------LPANSSIKKKAT------------VIVMAIEKQPLLTPVLRCDYEACRLALLGMEQSLLMELDAGEVENIPHERCDGNRNVLHACVSTCFPTSNKEAK 410

HSP 3 Score: 61.6178 bits (148), Expect = 3.946e-9
Identity = 23/43 (53.49%), Postives = 30/43 (69.77%), Query Frame = 2

Query: 1874 VCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSV 2002
            VCM+N P++ AGA+ F+V  GVPK+G L E  W + D CRF V
Sbjct:    1 VCMRNNPVYQAGAVAFSVSSGVPKVGVLQESVWNMNDCCRFRV 43

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Sea Lamprey
Match: ube3a (ubiquitin protein ligase E3A [Source:ZFIN;Acc:ZDB-GENE-041114-190])

HSP 1 Score: 78.1814 bits (191), Expect = 3.376e-14
Identity = 74/293 (25.26%), Postives = 127/293 (43.34%), Query Frame = 2

Query: 10223 VGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGL-SPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAI-ETKSFGFV 11095
            +G V+G+++  N  + +     V + ++G    +HD A  +  LY+SL+ L+            G+ ED ++     F I   +  G                +L  NGED+ V ++N  ++V  Y    +   V+ Q    + G + V  +  L  L  PE++ LL+ G+  ++   L        E +        K ++  + FW  V  F   +++  L F T +   P    G   M      P  D  LPTA+TC + L +P YS++  L+E+LL+AI   K FG +
Sbjct:  607 IGIVLGLAIYNNCILDIHFPMVVYRKLMGKRGTFHDLADSHPALYQSLKDLL---------AYEGSVEDDIMA---TFRISYFDMFGTPITQ-----------DLKENGEDIPVTNDNKKEFVDLYAEYILNQSVEKQFKAFRRGFHMVTSESPLKALFRPEEVELLVCGSRVLDFHAL--------EDATEYDGGFNKSSRVIRDFWDTVHDFCEDKKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDSD-RLPTAHTCFNVLLLPEYSSREKLKERLLKAITHAKGFGML 867

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Sea Lamprey
Match: wwp2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:ZFIN;Acc:ZDB-GENE-000607-82])

HSP 1 Score: 75.0998 bits (183), Expect = 2.638e-13
Identity = 62/207 (29.95%), Postives = 96/207 (46.38%), Query Frame = 2

Query: 10496 SGDRKVIG-MNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQ-------PMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAI-ETKSFG 11089
            S D +++G ++S +L P+G D+ V   N  +Y+      R    V+ Q     +G  +V+P   L      +L ++L G  EI++          D    TI     + +K   WFWQVV   ++ +R  LL F T +  LP    GF        P      +   +  LP ++TC +RL +P Y +   L+EKLL AI ET+ FG
Sbjct:  735 SVDMELLGKVSSHDLKPDGSDILVTEENKEEYIGLMTEWRFSRGVEEQTKAFLDGFSEVVPLQWLLYFDERELEVMLCGMQEIDLA---------DWQRSTIYRHYNRSSKQISWFWQVVKEMDNEKRLRLLQFVTGTCRLPVG--GFAELIGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFG 930

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Sea Lamprey
Match: nedd4a (NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;Acc:ZDB-GENE-051005-2])

HSP 1 Score: 73.559 bits (179), Expect = 4.102e-13
Identity = 72/294 (24.49%), Postives = 127/294 (43.20%), Query Frame = 2

Query: 10223 VGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNS--INLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMP--------TITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIE 11074
            +GRV G+++   + +     R   K +L  PI  +D    +S+ Y SL  +++               DP  + +L F I             D ++ G  +  + L PNG ++ V + N  +Y++     R +  V+ Q++    G  +++P   +      +L LL+ G  +++V     +T +         NS        +WFW+ V+  +  +R  LL F T +  +P +  GF  +         TI +    +  LP A+TC +RL +P Y +   LREKL  AIE
Sbjct:  231 IGRVAGMAVFHGKLLDGFFIRPFYKMMLQKPITLNDMESVDSEYYNSLMWILE--------------NDPA-DLDLRFCI-------------DEEMFGQQTHLVELKPNGSEILVTNENKKEYIELVIQWRFVERVQKQINAFMEGFSELIPMDLIKIFDENELELLMCGLGDVDVNDWRQHTIY--------KNSYCANHPVIQWFWKAVLLMDGEKRIRLLQFVTGTSRVPMN--GFAELYGSNGPQLFTIEMWSTSE-KLPRAHTCFNRLDLPPYESFDDLREKLNIAIE 485

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Yeast
Match: RSP5 (NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome [Source:SGD;Acc:S000000927])

HSP 1 Score: 89.7373 bits (221), Expect = 5.917e-18
Identity = 70/302 (23.18%), Postives = 135/302 (44.70%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSF--LDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASN----QGFQPMPTITIRPADDF-HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            N ++ +GRV+G+ +     +       + K +L   +   D    ++++Y SL  ++    E  + G+            L+ T    +E  G           + +++L P+G +++V   N  +YV+ Y   R++  V+ Q     +G  +++P+  +      +L LL+ G  EI++E    +T +    ES   I           +WFW+ V  +++ QR  LL F T +  +P +     QG       TI  A +   LP ++TC +R+ +P Y     +++KL  A+E ++ GF
Sbjct:  543 NYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWML----ENSIDGV------------LDLTFSADDERFGE----------VVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVI-----------QWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVE-ETIGF 806

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Yeast
Match: TOM1 (E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase [Source:SGD;Acc:S000002865])

HSP 1 Score: 86.2705 bits (212), Expect = 1.009e-16
Identity = 76/303 (25.08%), Postives = 134/303 (44.22%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTIT----IRPADDF----HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            + ++ +G +IG ++     +     R V K ILG P+   D    +   Y+SL  +++                     N    I+         + G+ KVI     NLI  G+D+ V   N   YVKK    ++ T VK Q+D    G Y ++ K  +     ++L LL++G  +I+V+   + T++++ ++           K   +FW+ V +F++ +R  LL F T +  +P +  GF+ +  +          DF     LP+++TC ++L +P Y +   LR  LL AI     GF
Sbjct: 3000 SFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWILE---------------------NDITDIIEETFSVETDDYGEHKVI-----NLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPDIDVDDWKNNTTYVNYTA---------TCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLN--GFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEGF 3265

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Yeast
Match: HUL5 (Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock [Source:SGD;Acc:S000003109])

HSP 1 Score: 83.5741 bits (205), Expect = 4.253e-16
Identity = 78/291 (26.80%), Postives = 129/291 (44.33%), Query Frame = 2

Query: 10217 RSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGT-DEINVEVLISYTSF--LDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPM-PTITIRPA--DDFHLPTANTCISRLYIPLYSTKIILREKLLQAI 11071
            + VG+ +   +L++ +      + +L Y  G    + D   ++S LY +L +L+ +              D +   +L F I             D        ++LIPNG    V  +NV  YV K    ++       +     G+  ++  H +   +  +L++L++G  D I+++ L S T +    E   TI +           FW+V+  F   ++ N L F TS P  P   QGF+ + P   IR A  + + LPTA+TC++ L +P Y  K ILREKLL AI
Sbjct:  649 KVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMT------------TDEIKSLDLTFEI-------------DEPESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGYKEEDQTIVD-----------FWEVLNEFKFEEKLNFLKFVTSVPQAPL--QGFKALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAI 901

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Yeast
Match: UFD4 (Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000001493])

HSP 1 Score: 69.3218 bits (168), Expect = 1.393e-11
Identity = 61/230 (26.52%), Postives = 106/230 (46.09%), Query Frame = 2

Query: 10427 DPLLEYNLNFTIVPREEEGG-NGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASN-QGFQPMPTITIRPADDF-----HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            DPLL  +L + +  +++       S    V G + I LIP G +  ++S+NV +Y+       +   ++ QL     G   V     +  L P++L  +    +E +  +   YT+   E   T+ +S          F  ++ AF   +R+  L F T SP LP    +   P  T+ ++ A+D      +LP+  TC + L +P Y++K I+R +L QAIE  +  F+
Sbjct: 1259 DPLLAKSLKYIVANKDDNMTLESLSLTFTVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFGRVEE-DWSMATLYTNLNAEHGYTMDSS------IIHDFISIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAGAFL 1481

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Yeast
Match: HUL4 (Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex [Source:SGD;Acc:S000003797])

HSP 1 Score: 62.7734 bits (151), Expect = 9.573e-10
Identity = 72/314 (22.93%), Postives = 147/314 (46.82%), Query Frame = 2

Query: 10172 NLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLY-ESLRQLMKVAREAQLMGIAGAPEDPLLE-YNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPK-HALNGLSPEDLRLLLNGTDE---INVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAI-ETKSFGF 11092
            N + +  + ++  +Y   G V+G+++  +  + L+  + + K +   P+ + D+    S+L+ E+ R L+K         +    ED   + ++L F    R       +S   K     ++ L  NG +V +  +N  ++V K+    +   ++PQ ++  +G   V  + +++   + E+L  L+ G +E    + + L S T ++       S+    V     WFW+++ +++   ++ LL F T+S  +PA+     P     +   D   LP A+TC + + +  YS+K  L  KLL AI E++ +GF
Sbjct:  601 NFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDY----SELFPETSRNLIK---------MLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSK--EYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVG----GFSDDSRAVC----WFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGYGF 891

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Nematostella
Match: EDO37117 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGN1])

HSP 1 Score: 186.422 bits (472), Expect = 2.400e-52
Identity = 104/300 (34.67%), Postives = 161/300 (53.67%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLN-GTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMP----TITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
             +Y ++GR IG+S+  N T+PL   RHV+K++L   + W D AFFN+ L+E L ++M  A    +       E     Y  +F                   +G  +  L+P G  + V   N++QYV+ Y    MI  V+ +L  +++G+YDV+P   L  LSPED +LL++ GT +I++  L S  +F + + C    S++ + +FK+WFW +V     +QRQ LLYF T S  LP  +    P      T+ +   +   LP A TC  R+ IPLY +K IL++KLLQAI+ +S+G 
Sbjct:    3 KMYTAIGRFIGLSLWFNNTVPLNFSRHVVKFLLSRDVTWEDLAFFNADLFEGLSRMMIDANHPLM-----TSETFQATYCCHF----------------ETSVGGTTEELVPGGSHLPVSPENIYQYVRLYASKVMIGCVEAELQSMRSGLYDVIPSELLTSLSPEDFQLLVSGGTTDIDMNKLRSVITFTNSNGC----SKDILERFKRWFWSIVQKMTPLQRQQLLYFCTGSAVLPVMSDRRDPDQELNITVDVISGNTKALPMATTCGQRMSIPLYPSKRILKKKLLQAIQCQSYGL 277

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Nematostella
Match: EDO34473 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SP65])

HSP 1 Score: 88.9669 bits (219), Expect = 5.815e-18
Identity = 58/204 (28.43%), Postives = 102/204 (50.00%), Query Frame = 2

Query: 10508 KVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSF--LDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITIRPAD--DFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            +  G++ I +LIPNG ++ V   N  +YVK  C  +M   ++ Q+D    G Y+++PK  ++  + ++L LL++G   I+++ L S+  +   +E+S  I           +WFW+ + +F+   R   L F T +  +P    A+ +G        I   D     LP+A+TC ++L +P Y T   LR  L +A +    GF
Sbjct:  205 REFGLSEIRDLIPNGRNIPVTEENKREYVKLVCQMKMTGAIRKQIDSFLEGFYEIIPKRLISIFNEQELELLISGLPNIDLDDLKSHIEYHKYNENSLQI-----------QWFWRALRSFDQAARAKFLQFVTGTSKVPLQGFAALEGMNGFQKFQIHRDDRNTDRLPSAHTCFNQLDLPAYETYDKLRTMLKKACDECPEGF 397

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Nematostella
Match: EDO46071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR93])

HSP 1 Score: 85.8853 bits (211), Expect = 2.666e-16
Identity = 80/303 (26.40%), Postives = 136/303 (44.88%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPM------PTITIRPADDFH-LPTANTCISRLYIPLYSTKIILREKLLQAIE-TKSFGFV 11095
            ++ +GRV G+++   + +     R   K +LG PI   D    +S+ Y SL  +++             PED     +L+F +             D ++ G+ S+ +L PNG   +V + N  +Y+      R ++ V+ Q+     G  D++P + +      +L LL+ G  EI+       +++  E      + +  V    +WFW+ V +F+   R  LL F T +  +P +  GF  +         TI P    H LP A+TC +RL +P Y +   LRE+L  AIE T+ F  V
Sbjct:  724 FKFIGRVAGMAVYHGKLLDAFFIRPFYKMMLGRPITLIDMESVDSEYYNSLNWILE-----------NDPED----LDLHFCV-------------DEELFGILSVKDLKPNGSQTNVTNENKREYINLVIKWRFVSRVEDQMRAFMEGFCDLIPHNLIQIFDERELELLMCGLGEIDTVDWRKNSNYRGE-----YHDKHIVI---QWFWKAVNSFDIETRARLLQFVTGTSRVPMN--GFSELYGSNGPQRFTIEPWGTPHSLPRAHTCFNRLDLPRYRSYYELRERLRIAIENTQGFEGV 988

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Nematostella
Match: EDO49383 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG94])

HSP 1 Score: 82.8037 bits (203), Expect = 2.855e-16
Identity = 80/311 (25.72%), Postives = 135/311 (43.41%), Query Frame = 2

Query: 10181 DNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTIT-------IRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAI-ETKSFG 11089
            DN+ E+     +R  GR++G+ ++    +     R   K +L       D    ++  ++S+  +           I    ED L   +L F++     E   G   +R+        LIP G+D+ V   N   YV +    R+   V  Q++ I  G  +V+    +N     +L L+++GT +I+++     T +         +      K  KWFW+ V +F++ QR  LL F T + ++P   +GF  +   T        R  D   LP A+TC +RL +P+Y +   L EKL  A+ ET SF 
Sbjct:   68 DNSHEW-----FRFCGRIVGLVIIHQHLLDAFFTRTFYKALLRSLCDLSDVEALDALFHQSMTWV-----------IENDIEDVL---DLTFSV----SEEIFGQVTERE--------LIPGGKDIAVTEQNKGDYVAEMVKWRVERGVSEQMESIVRGFNEVIDPALVNIFDARELELVISGTADIDIKDWRRNTEY--------RSGYHDNHKVVKWFWKAVSSFDNEQRLRLLQFVTGTSSIPY--EGFAALRGSTGPRKFSIERWGDYTKLPRAHTCFNRLDMPIYRSYDELLEKLTYAVEETGSFA 337

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Nematostella
Match: EDO40302 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7U7])

HSP 1 Score: 83.1889 bits (204), Expect = 1.482e-15
Identity = 83/324 (25.62%), Postives = 135/324 (41.67%), Query Frame = 2

Query: 10130 WQPGHPGF-YCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDF-HLPTANTCISRLYIPLYSTKIILREKLLQAIE-TKSFGF 11092
            ++PG+  F Y      +  N + +     +  VG V+G+++     + +   + + K + G      D       L  SL+QL++           G  ED        F    +      G   DR+        LIPNG +V V++ N  ++V +Y    ++  V  Q D    G + V    AL     ++L LL+ G   ++   L+   S+ D  S   S          K FW V     + Q++ LL F T S  +P   +G   +  I  +   D   LPTA TC +RL +P Y++   L+E+L+ AIE +K FG 
Sbjct:  407 FEPGYGMFTYIEESRTMWINGESFESLKEFELVGIVLGLAIYNGIILDIHFPQVIYKKLQGQTPSLEDLIGVQPSLGNSLKQLLEYE---------GDVED-------TFCYTFQVSAMSYGKVCDRE--------LIPNGAEVPVNNENREEFVHRYVKYLLVDSVAKQFDAFSAGFHKVCGGSALTLFCADELELLICGHHVLDFSDLVLAASYDDGYSAQHSTI--------KMFWNVFNEMTNHQKKALLMFVTGSDRVPL--KGLSNLTFIIQKHGQDSDRLPTAMTCFNRLLLPEYTSPKRLKERLIVAIENSKGFGL 696

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Medaka
Match: ubr5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:NCBI gene;Acc:101165756])

HSP 1 Score: 325.865 bits (834), Expect = 1.788e-88
Identity = 197/500 (39.40%), Postives = 290/500 (58.00%), Query Frame = 2

Query: 4001 LDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSV--LNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTAS--SSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            ++ K++++N++ I+ ++ +   +  HL  LLS ++A G TPFM +VS R YP A+ +L+    +  +   ++   +    + + MI P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  +AR +LL +LL  T+L T PN R EH+LLFLV+TV RQ  EH Q R    R      N +  N                  A +  MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K A   + +D LL TL KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  C+R+F+ LL  ++ EL  ++  +I PVR G+ +PTA +       DAV+  +++F
Sbjct: 1107 VESKDRKANAHLILKLMCDSVVLRPHLQELLSAKDARGMTPFMLAVSGRAYPAAITVLEAAQKIAKVGDPAIGDKDGADSVFMEMICPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKAARLDLLYRLLTTTNLVTTPNSRGEHILLFLVQTVARQSVEHCQYRPPRIREDR---NRKAAN------------------AEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIAHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKCAPDITFIDTLLGTLVKELQNKYT------PGRREEAVIVTRRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCRRVFQALLPYAVEELCNVSESLIVPVRMGIARPTAPFTLASTSIDAVQGSEELF 1548

HSP 2 Score: 314.694 bits (805), Expect = 5.207e-85
Identity = 155/326 (47.55%), Postives = 217/326 (66.56%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL++ ++  +   +  A        +L F I   +EEG               + L+  G ++ V   NV++YV++Y   RM+ + +  L  ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + +K+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2562 APLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLIRHSQTGEADAVFAA-------MDLAFAIDLCKEEGAG------------QVELVSGGVNMPVTPLNVYEYVRRYAEHRMLVVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENADKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2859

HSP 3 Score: 222.631 bits (566), Expect = 3.662e-57
Identity = 178/533 (33.40%), Postives = 265/533 (49.72%), Query Frame = 2

Query:  545 SSSHTSAPRVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSS---MANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCP 2110
            +++  S  +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R    S   S   +   +E  ++  + R    +LR       R + DG    +  G+ S    P      +S PV ++ + LG  L++W +K         +KF+ I  M+SEL+ ++T  +L+QW+W + EP+ +  + SN                        +H R   L L  E+I  LSA S RATV T + K+ATWVDET++ +                ++EH    F EL+ E +  L   +L +  +  + ++YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F+V  G+PK+G LLE  W + D CRF +R  +SL N  +       Q I   S   L    M P
Sbjct:  179 TAARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELITQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDTERGSTSREGEPS--LDKKSIPV-QSPVSLGEELQWWPDK-------DGVKFVSIGAMFSELVAVSTKGELYQWKWSEPEPYRNPQNPSN------------------------HHPRASFLGLTNERITLLSANSIRATVATETNKVATWVDETLSTVAS--------------KLEHSAQAFPELQGERMVSLHCCSLYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISS--------------IPNITVGTQVCLRNNPLYHAGAVAFSVSAGIPKVGVLLESVWNMNDSCRFQLRSPESLKNMEKT---TKTQEIKMESKPELVKTEMGP 639

HSP 4 Score: 155.606 bits (392), Expect = 8.760e-37
Identity = 124/390 (31.79%), Postives = 180/390 (46.15%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYDG-FVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF                P  +   NN         N+T P   DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS   FLG++                 +N  I  A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+ C+  G  ++ N       +P   SNST            +  V ++ +E QTLM H+LR D +     + N   AV  +  G  ++ ++  + DG RNI+H AV++C P+SN
Sbjct:  662 KRRRSTPAPKEEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKF----------------PGTSSSMNNQ--------NTTAPPDSDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKA-------------EILAVNVDSKGVHAVLK---TGNWVRYCIFDLATGKAEQENNFPTSNLAFLGQSE----------------RNVAISTAGQESPIVLRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISCLGMGVHSLAN-------LP---SNSTIK---------KKAAVIIMAVEKQTLMQHVLRCDYEACRQYLVNLEQAVLLDQGGQALEALLGHRCDGNRNILHAAVSVCFPVSN 966

HSP 5 Score: 134.806 bits (338), Expect = 1.620e-30
Identity = 67/128 (52.34%), Postives = 87/128 (67.97%), Query Frame = 2

Query: 8054 LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRN   RDL+L V+R+R+ +I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A A+LS + L
Sbjct: 2242 LLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNLQSRDLALEVDRDRDQLIQQTMRQLNAHFGRRCTT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIALALLSNDKL 2366

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Medaka
Match: ubr5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:NCBI gene;Acc:101165756])

HSP 1 Score: 325.865 bits (834), Expect = 1.826e-88
Identity = 197/500 (39.40%), Postives = 290/500 (58.00%), Query Frame = 2

Query: 4001 LDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSV--LNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTAS--SSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            ++ K++++N++ I+ ++ +   +  HL  LLS ++A G TPFM +VS R YP A+ +L+    +  +   ++   +    + + MI P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  +AR +LL +LL  T+L T PN R EH+LLFLV+TV RQ  EH Q R    R      N +  N                  A +  MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K A   + +D LL TL KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  C+R+F+ LL  ++ EL  ++  +I PVR G+ +PTA +       DAV+  +++F
Sbjct: 1107 VESKDRKANAHLILKLMCDSVVLRPHLQELLSAKDARGMTPFMLAVSGRAYPAAITVLEAAQKIAKVGDPAIGDKDGADSVFMEMICPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKAARLDLLYRLLTTTNLVTTPNSRGEHILLFLVQTVARQSVEHCQYRPPRIREDR---NRKAAN------------------AEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIAHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKCAPDITFIDTLLGTLVKELQNKYT------PGRREEAVIVTRRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCRRVFQALLPYAVEELCNVSESLIVPVRMGIARPTAPFTLASTSIDAVQGSEELF 1548

HSP 2 Score: 314.694 bits (805), Expect = 5.454e-85
Identity = 155/326 (47.55%), Postives = 217/326 (66.56%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL++ ++  +   +  A        +L F I   +EEG               + L+  G ++ V   NV++YV++Y   RM+ + +  L  ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + +K+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2551 APLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLIRHSQTGEADAVFAA-------MDLAFAIDLCKEEGAG------------QVELVSGGVNMPVTPLNVYEYVRRYAEHRMLVVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENADKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2848

HSP 3 Score: 223.016 bits (567), Expect = 3.474e-57
Identity = 178/533 (33.40%), Postives = 265/533 (49.72%), Query Frame = 2

Query:  545 SSSHTSAPRVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSS---MANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCP 2110
            +++  S  +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R    S   S   +   +E  ++  + R    +LR       R + DG    +  G+ S    P      +S PV ++ + LG  L++W +K         +KF+ I  M+SEL+ ++T  +L+QW+W + EP+ +  + SN                        +H R   L L  E+I  LSA S RATV T + K+ATWVDET++ +                ++EH    F EL+ E +  L   +L +  +  + ++YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F+V  G+PK+G LLE  W + D CRF +R  +SL N  +       Q I   S   L    M P
Sbjct:  179 TAARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELITQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDTERGSTSREGEPS--LDKKSIPV-QSPVSLGEELQWWPDK-------DGVKFVSIGAMFSELVAVSTKGELYQWKWSEPEPYRNPQNPSN------------------------HHPRASFLGLTNERITLLSANSIRATVATETNKVATWVDETLSTVAS--------------KLEHSAQAFPELQGERMVSLHCCSLYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISS--------------IPNITVGTQVCLRNNPLYHAGAVAFSVSAGIPKVGVLLESVWNMNDSCRFQLRSPESLKNMEKT---TKTQEIKMESKPELVKTEMGP 639

HSP 4 Score: 155.606 bits (392), Expect = 8.531e-37
Identity = 124/390 (31.79%), Postives = 180/390 (46.15%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYDG-FVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF                P  +   NN         N+T P   DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS   FLG++                 +N  I  A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+ C+  G  ++ N       +P   SNST            +  V ++ +E QTLM H+LR D +     + N   AV  +  G  ++ ++  + DG RNI+H AV++C P+SN
Sbjct:  662 KRRRSTPAPKEEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKF----------------PGTSSSMNNQ--------NTTAPPDSDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKA-------------EILAVNVDSKGVHAVLK---TGNWVRYCIFDLATGKAEQENNFPTSNLAFLGQSE----------------RNVAISTAGQESPIVLRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISCLGMGVHSLAN-------LP---SNSTIK---------KKAAVIIMAVEKQTLMQHVLRCDYEACRQYLVNLEQAVLLDQGGQALEALLGHRCDGNRNILHAAVSVCFPVSN 966

HSP 5 Score: 134.806 bits (338), Expect = 1.660e-30
Identity = 67/128 (52.34%), Postives = 87/128 (67.97%), Query Frame = 2

Query: 8054 LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRN   RDL+L V+R+R+ +I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A A+LS + L
Sbjct: 2231 LLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNLQSRDLALEVDRDRDQLIQQTMRQLNAHFGRRCTT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIALALLSNDKL 2355

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Medaka
Match: ubr5 (ubiquitin protein ligase E3 component n-recognin 5 [Source:NCBI gene;Acc:101165756])

HSP 1 Score: 325.865 bits (834), Expect = 1.841e-88
Identity = 197/500 (39.40%), Postives = 290/500 (58.00%), Query Frame = 2

Query: 4001 LDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSV--LNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTAS--SSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIF 5488
            ++ K++++N++ I+ ++ +   +  HL  LLS ++A G TPFM +VS R YP A+ +L+    +  +   ++   +    + + MI P   +            +D+PL VLC ND CSFTWTG +HI QDIFECRTCGL ESLCCCTECARVCHKGHDC LK+TSPTAYCDCWEKC+CK LI G  +AR +LL +LL  T+L T PN R EH+LLFLV+TV RQ  EH Q R    R      N +  N                  A +  MP++ LEP  FA  AL+ VL +W +++++++ G + +        + +SSR   + P  +++V+LN QS + +LD F   LI K A   + +D LL TL KELQN+ +      P  + +      R +RSVARVFV L ++MA   + K+++N +          P+P+  C+R+F+ LL  ++ EL  ++  +I PVR G+ +PTA +       DAV+  +++F
Sbjct: 1067 VESKDRKANAHLILKLMCDSVVLRPHLQELLSAKDARGMTPFMLAVSGRAYPAAITVLEAAQKIAKVGDPAIGDKDGADSVFMEMICPSGTNP-----------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKAARLDLLYRLLTTTNLVTTPNSRGEHILLFLVQTVARQSVEHCQYRPPRIREDR---NRKAAN------------------AEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQEN-----KDPLSASSRIAHLLP--EEQVYLNQQSGTIRLDCFTHCLIVKCAPDITFIDTLLGTLVKELQNKYT------PGRREEAVIVTRRFLRSVARVFVILSVEMA---SSKKKNNFI----------PQPIGKCRRVFQALLPYAVEELCNVSESLIVPVRMGIARPTAPFTLASTSIDAVQGSEELF 1508

HSP 2 Score: 315.079 bits (806), Expect = 3.739e-85
Identity = 155/326 (47.55%), Postives = 217/326 (66.56%), Query Frame = 2

Query: 10118 TPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
             PLF+QPG  GFY PR       N E  R N +R++GR++G+ +L NE  P+ L RHV+K +LG  + WHDFAFF+  +YESLRQL++ ++  +   +  A        +L F I   +EEG               + L+  G ++ V   NV++YV++Y   RM+ + +  L  ++ G+ DVLPK+AL  L+ ED RLL+NG  E+NV++LIS+TSF DES      + +K+ +FK+WFW +V   +  +RQ+L+YFWTSSP+LPAS +GFQPMP+ITIRP DD HLPTANTCISRLY+PLYS+K IL++KLL AI+TK+FGFV
Sbjct: 2511 APLFYQPGKRGFYSPR----PGKNTE-ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLIRHSQTGEADAVFAA-------MDLAFAIDLCKEEGAG------------QVELVSGGVNMPVTPLNVYEYVRRYAEHRMLVVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESG----ENADKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2808

HSP 3 Score: 223.016 bits (567), Expect = 3.504e-57
Identity = 179/533 (33.58%), Postives = 265/533 (49.72%), Query Frame = 2

Query:  545 SSSHTSAPRVNFIREMQRQGIYFARTFPTP-IAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDI----FPSIRLRRESLYSS---MANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCV-SRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNR--DRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCP 2110
            +++  S  +   IR  + +G     + P P I AS +PE+LI Q Q VLQGKSR +IIRELQRTNLDVN+AVNNLLSRDDE  ++G  +A + +   +DL+SLLD   +    + I D     +EDI    +PS R    S   S   +   +E  ++  + R    +LR       R + DG    +  G+ S    P    K  S PV ++ + LG  L++W +K         +KF+ I  M+SEL+ ++T  +L+QW+W + EP+ +  + SN                        +H R   L L  E+I  LSA S RATV T + K+ATWVDET++ +                ++EH    F EL+ E +  L   +L +  +  + ++YWWGV+PF  RK  +EK R  ++ PK+    +                 NI  G+ VC++N P++HAGA+ F+V  G+PK+G LLE  W + D CRF +R  +SL N  +       Q I   S   L    M P
Sbjct:  139 TAARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELITQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRE------RRWLDGASFDTERGSTSREGEPSLDKK--SIPV-QSPVSLGEELQWWPDK-------DGVKFVSIGAMFSELVAVSTKGELYQWKWSEPEPYRNPQNPSN------------------------HHPRASFLGLTNERITLLSANSIRATVATETNKVATWVDETLSTVAS--------------KLEHSAQAFPELQGERMVSLHCCSLYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISS--------------IPNITVGTQVCLRNNPLYHAGAVAFSVSAGIPKVGVLLESVWNMNDSCRFQLRSPESLKNMEKT---TKTQEIKMESKPELVKTEMGP 599

HSP 4 Score: 155.606 bits (392), Expect = 8.490e-37
Identity = 124/390 (31.79%), Postives = 180/390 (46.15%), Query Frame = 2

Query: 2534 KSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPK--CIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGK-KVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNF--AVGSEYDG-FVQRIISEKLDGQRNIIHVAVNMCRPLSN 3685
            K   ST  P+ +    EE W L++V+F+ED +  PVG VLKVDG+  AVKF                P  +   NN         N+T P   DP S L DCRLLR +EL VVK     +VPD  Q+ PK  CIP +               IL + V+++ +H +++   +   + Y +  L   K    +   TS   FLG++                 +N  I  A +  PI LRDGNGT+YP+      + + M      I  P WLDLPP+ C+  G  ++ N       +P   SNST            +  V ++ +E QTLM H+LR D +     + N   AV  +  G  ++ ++  + DG RNI+H AV++C P+SN
Sbjct:  622 KRRRSTPAPKEEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKF----------------PGTSSSMNNQ--------NTTAPPDSDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKA-------------EILAVNVDSKGVHAVLK---TGNWVRYCIFDLATGKAEQENNFPTSNLAFLGQSE----------------RNVAISTAGQESPIVLRDGNGTIYPM------AKDCMGG----IRDPDWLDLPPISCLGMGVHSLAN-------LP---SNSTIK---------KKAAVIIMAVEKQTLMQHVLRCDYEACRQYLVNLEQAVLLDQGGQALEALLGHRCDGNRNILHAAVSVCFPVSN 926

HSP 5 Score: 134.806 bits (338), Expect = 1.653e-30
Identity = 69/138 (50.00%), Postives = 92/138 (66.67%), Query Frame = 2

Query: 8030 FSGVPVGN--LRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELL 8437
            F G+ + +  L  RWR SLEL    F ++VG EPGS+L +   F +KE++FR+EMEKLRN   RDL+L V+R+R+ +I  T+ QLN  + RR +T    P+  HR KV F DEPGEG+GVARSF T  A A+LS + L
Sbjct: 2181 FMGMMISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNLQSRDLALEVDRDRDQLIQQTMRQLNAHFGRRCTT---TPMAVHRVKVTFKDEPGEGSGVARSFYTAIALALLSNDKL 2315

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Medaka
Match: huwe1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:101170019])

HSP 1 Score: 97.0561 bits (240), Expect = 4.878e-19
Identity = 74/300 (24.67%), Postives = 134/300 (44.67%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSI-NLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP----ASNQGFQPMPTITIRPADDF--HLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            ++ VGRV+  ++  N  +     R   K+ILG  + + D    +   ++ L  L++   +   +G           Y L F+   +E              G+  + +L PNG ++ V   N  +YV   C  +M   ++ QL     G Y+++PK  ++  + ++L LL++G   I+++ L + T +    S +I           +WFW+ + +F+   R   L F T +  +P    A+ +G   +    I   D     LP+A+TC ++L +P Y +   LR  LL AI+  S GF
Sbjct: 3856 FKFVGRVVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYPFFQGLVYLLE--NDVSTLG-----------YELTFSTEVQE-------------FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMKMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKANTEYHKYQSSSIQ---------IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECSEGF 4120

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Medaka
Match: hace1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:101171521])

HSP 1 Score: 95.5153 bits (236), Expect = 6.729e-19
Identity = 76/303 (25.08%), Postives = 134/303 (44.22%), Query Frame = 2

Query: 10208 NIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIG-MNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALP-------ASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            N ++  G+++G+++   + + +   R   K+ILG+P+ + D +  + +  ++L+ ++               ++ + +  L  T            S +  V G M  + L   G    V   N  +YV+     RM   ++PQ++    G +  +P   +      +L LLL+G  EI+VE     T +    S      QE V +   WFW+VV      +R  LL F T S  +P           G Q   TI   P     LPTA+TCI+ L +P Y + ++L+++LL A+   S+G+
Sbjct:  594 NYFQFAGQILGLALYHRQLVNIYFTRSFYKHILGIPVSYQDVSSIDPEYAKNLQWIL---------------DNDISDLGLELTF-----------SVETDVFGAMEEVPLKAGGTTTLVTQENKAEYVQLVTELRMTRAIQPQINAFLRGFHTFIPPSLIQLFDEYELELLLSGMPEIDVEDWFRNTEYTSGYS-----DQEPVVQ---WFWEVVKGLTQEERILLLQFVTGSSRVPHGGFAFLMGGSGLQKF-TIAAMPYTPNLLPTASTCINMLKLPEYPSLVVLQDRLLVALHCGSYGY 861

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Planmine SMEST
Match: SMESG000050687.1 (SMESG000050687.1)

HSP 1 Score: 6726.34 bits (17450), Expect = 0.000e+0
Identity = 3673/3681 (99.78%), Postives = 3676/3681 (99.86%), Query Frame = 2

Query:   53 MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLXXXXXXXXXXXXXXXXXXENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDIFPSIRLRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCPQLNTSFLYGLLGSSNKSINIAENNQNTTDSINVTGSSSNYKMPTTWAEMXXXXXXXXXTCSDQSGPVKISPGTFKRKKQSVNTSGTGDLVAEVNTEXXXXXXXXXXXXXXXCSDTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETEWKLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSMNISSFPYRRWIDMGRPINDVNQFNYSRSNDRQASSVRFTVMXXXXXXXXXILTGDSNSGWLLPPIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYSTNPDVDNRHEPVGNSDKNPKQNSQSNRINDSNLRNTPXXXXXXXXXXXXXXXXXXXXXXXXXLPEFHGNVRQNSLNGRQSRRRPYDDDIDGSGAVISISESNVTETNGRNLDPVQLVRRRRQSTPISLSSRMNALIXXXXXXXXXXXXXXXXXXXXXXRGISEDRQRSNQLNSIFFEESDGDGNTIEGENDLDGDVDMEVYDEDHDTDIVPETEXXXXXXXXXXXCVTEYNPEPVNMTELTANRSIEQNTNSSLSVINMVDSGIRMKVDRPDAMETNIDNSETPSSNNNAENNSVRISIRKSANIIENKGDPDSSANDTSMRMSMEDNIRFSVVASSDLTRSNPETTQSVLVELVTPLASVPNLIPQPTLNNATEWFRNQVXXXXXXXXXXXXXXXXXXXXXXXXXXMNESATDLSQPIAQQTQRNISSNSTIPDNSANPDXXXXXXXXXXXXXXXXXXXXXXXXVQLARAFCCLIKLLAGLLNQMYYSREKNESVNQKEYDRFGLNLGQDNEYSSSCSPGATLSQSEEEHVMIESSQQLGPIWIWICQSMDFLESQVCFANAFQRKHGTYKARPVPTFEQVNTPNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLXXXXXXXXXXXLNSLRPTIGSECGDSILDEDTNCPTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQLPLHMGFSSRWADRLLDNNIIFSGVPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELLIMXXXXXXXXXXXXGISSRGSLYNRNEHNYIRMSAISRINTIAANTSSNISQTLNSIPSSSWYSDALSIIGMXXXXXXXXXXXXFRPAMRIISNPQTVQSNSSNIPSTRSIIRSDLSYTNTAHRLXXXXXXXXXXXXXXXNTSTSHVWGITXXXXXXXXXIPQSTSINFSHYNIDNMPLVSTPHRLDFSDRGISRRSINMASSRPPIXXXXXXXXXXXXXXXXXMGNNINXXXXXXXXXXXVTTRSVNSNTDMIYSNSQIPMXXXXXXXXXXNAQLGNIDPINLATGFTASLGNQAPIWVSSNWLPMYXXXXXXXXXXXXXXXXXRIQGFSPLHNQIPTSRHLEPSSIPTSSIANIQSNQNLNIYEMLRGKLPVNDPIYTMPASIRIPDIPTSSISSLPGTSGLSSIQNISIFDILRSRIPGDDSLIQQMAYNLTAISGRSDLNGLLNQLSLKNINMNDVINNLMNSMDQVPRFSDLHQSESAIVYSNIEGXXXXXXXXXXNIEVSIITFAIYLDXXXXXXXXXXXFSAAKSQPDDSSSLLPESHGPSTVLKTPSIDPEQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLTTSTESSQSKTFSSSRPTENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPDDWEEADDLLSLLDHADNPLLETAITDGTLGITEDIFPSIRLRRESLYSSMANDIESFADRRKRRRLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQRNKRNNNNANNKDTANIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCPQLNTSFLYGLLGSSNKSINIAENNQNTTDSINVTGSSSNYKMPTTWAEMPPPPSPASSTCSDQSGPVKISPGTFKRKKQSVNTSGTGDLVAEVNTESRPISNNNNRSNKIRCSDTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQP EEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNN+SSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETEWKLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSMNISSFPYRRWIDMGRPINDVNQFNYSRSNDRQASSVRFTVMSSSNTSRSSILTGDSNSGWLLPPIHLDEKEKRSNSYRIINIIINHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPAISIAANKNSISSMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLN RHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYSTNPDVDNRHEPVGNSDKNPKQNSQSNRINDSNLRNTPNISRRTSINNRNNGASDSNSSNGNNLPEFHGNVRQNSLNGRQSRRRPYDDDIDGSGAVISISESNVTETNGRNLDPVQLVRRRRQSTPISLSSRMNALIDEEDEDDGHSSGDDNWNSNNDSRGISEDRQRSNQLNSIFFEESDGDGNTIEGENDLDGDVDMEVYDEDHDTDIVPETESDSDDSISSSICVTEYNPEPVNMTELTANRSIEQNTNSSLSVINMVDSGIRMKVDRPDAMETNIDNSETPSSNNNAENNSVRISIRKSANIIENKGDPDSSANDTSMRMSM+DNIRFSVVASSDLTRSNPETTQSVLVELVTPLASV NLIPQPTLNNATEWFRNQVDLDAISDDESDDDESSQITEDDDQDDMNESATDLSQPIAQQTQRNISSNSTIPDNSANPDTQTNAQANTNSTTGNTTCGLQTTQVQLARAFCCLIKLLAGLLNQMYYSREKNESVNQKEYDRFGLNLGQDNEYSSSCSPGATLSQSEEEHVMIESSQQLGPIWIWICQSMDFLESQVCFANAFQRKHGTYKARPVPTFEQVNTPNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLVQEEVDDEQEDLNSLRPTIGSECGDSILDEDTNCPTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQLPLHMGFSSRWADRLLDNNIIFSGVPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELLIMNSSLSNQKKQSSGISSRGSLYNRNEHNYIRMSAISRINTIAANTSSNISQTLNSIPSSSWYSDALSIIGMNHNSSNNSSSRNFRPAMRIISNPQTVQSNSSNIPSTRS IRSDLSYTNTAHRLISAIAIFASSAPIVSNTSTSHVWGITSNSSNLNNSIPQSTSINFSHYNIDNMPLVSTPHRLDFSDRGISRRSINMASSRPPISST SVLSTSSFSSVSLMGNNINLPSSHLHSLPSVTTRSVNSNTDMIYSNSQIPMSIASESSISSNAQLGNIDPINLATGFTASLGNQAPIWVSSNWLPMYSNSASMSNSLTSLTNLSRIQGFSPLHNQIPTSRHLEPSSIPTSSIANIQSNQN+NIYEMLRGKLPVNDPIYTMPASIRIPDIPTSSISSLPGTSGLSSIQNISIFDILRSRIPGDDSLIQQMAYNLTAISGRSDLNGLLNQLSLKNINMNDVINNLMNSMDQVPRFSDLHQSESAIVYSNIEGSSETSQSTESNIEVSIITFAIYLDSLLNTNNSSSNFSAAKSQPDDSSSLLPESHGPSTVLKTPSIDPEQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV
Sbjct:    1 MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLTTSTESSQSKTFSSSRPTENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPDDWEEADDLLSLLDHADNPLLETAITDGTLGITEDIFPSIRLRRESLYSSMANDIESFADRRKRRRLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQRNKRNNNNANNKDTANIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCPQLNTSFLYGLLGSSNKSINIAENNQNTTDSINVTGSSSNYKMPTTWAEMPPPPSPASSTCSDQSGPVKISPGTFKRKKQSVNTSGTGDLVAEVNTESRPISNNNNRSNKIRCSDTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPQEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNLSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETEWKLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSMNISSFPYRRWIDMGRPINDVNQFNYSRSNDRQASSVRFTVMSSSNTSRSSILTGDSNSGWLLPPIHLDEKEKRSNSYRIINIIINHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPAISIAANKNSISSMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNTRHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYSTNPDVDNRHEPVGNSDKNPKQNSQSNRINDSNLRNTPNISRRTSINNRNNGASDSNSSNGNNLPEFHGNVRQNSLNGRQSRRRPYDDDIDGSGAVISISESNVTETNGRNLDPVQLVRRRRQSTPISLSSRMNALIDEEDEDDGHSSGDDNWNSNNDSRGISEDRQRSNQLNSIFFEESDGDGNTIEGENDLDGDVDMEVYDEDHDTDIVPETESDSDDSISSSICVTEYNPEPVNMTELTANRSIEQNTNSSLSVINMVDSGIRMKVDRPDAMETNIDNSETPSSNNNAENNSVRISIRKSANIIENKGDPDSSANDTSMRMSMDDNIRFSVVASSDLTRSNPETTQSVLVELVTPLASVSNLIPQPTLNNATEWFRNQVDLDAISDDESDDDESSQITEDDDQDDMNESATDLSQPIAQQTQRNISSNSTIPDNSANPDTQTNAQANTNSTTGNTTCGLQTTQVQLARAFCCLIKLLAGLLNQMYYSREKNESVNQKEYDRFGLNLGQDNEYSSSCSPGATLSQSEEEHVMIESSQQLGPIWIWICQSMDFLESQVCFANAFQRKHGTYKARPVPTFEQVNTPNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLVQEEVDDEQEDLNSLRPTIGSECGDSILDEDTNCPTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQLPLHMGFSSRWADRLLDNNIIFSGVPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELLIMNSSLSNQKKQSSGISSRGSLYNRNEHNYIRMSAISRINTIAANTSSNISQTLNSIPSSSWYSDALSIIGMNHNSSNNSSSRNFRPAMRIISNPQTVQSNSSNIPSTRSNIRSDLSYTNTAHRLISAIAIFASSAPIVSNTSTSHVWGITSNSSNLNNSIPQSTSINFSHYNIDNMPLVSTPHRLDFSDRGISRRSINMASSRPPISSTVSVLSTSSFSSVSLMGNNINLPSSHLHSLPSVTTRSVNSNTDMIYSNSQIPMSIASESSISSNAQLGNIDPINLATGFTASLGNQAPIWVSSNWLPMYSNSASMSNSLTSLTNLSRIQGFSPLHNQIPTSRHLEPSSIPTSSIANIQSNQNINIYEMLRGKLPVNDPIYTMPASIRIPDIPTSSISSLPGTSGLSSIQNISIFDILRSRIPGDDSLIQQMAYNLTAISGRSDLNGLLNQLSLKNINMNDVINNLMNSMDQVPRFSDLHQSESAIVYSNIEGSSETSQSTESNIEVSIITFAIYLDSLLNTNNSSSNFSAAKSQPDDSSSLLPESHGPSTVLKTPSIDPEQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 3681

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Planmine SMEST
Match: SMESG000050687.1 (SMESG000050687.1)

HSP 1 Score: 6687.44 bits (17349), Expect = 0.000e+0
Identity = 3658/3681 (99.38%), Postives = 3661/3681 (99.46%), Query Frame = 2

Query:   53 MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLXXXXXXXXXXXXXXXXXXENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPXXXXXXXXXXXXXXXXXNPLLETAITDGTLGITEDIFPSIRLRRESLYSSMANDIESFADXXXXXXLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQXXXXXXXXXXXXXXXXIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCPQLNTSFLYGLLGSSNKSINIAENNQNTTDSINVTGSSSNYKMPTTWAEMXXXXXXXXXTCSDQSGPVKISPGTFKRKKQSVNTSGTGDLVAEVNTEXXXXXXXXXXXXXXXCSDTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETEWKLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSMNISSFPYRRWIDMGRPINDVNQFNYSRSNDRQASSVRFTVMXXXXXXXXXILTGDSNSGWLLPPIHLDEKEKRSNSYRXXXXXXXHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPXXXXXXXXXXXXXMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYSTNPDVDNRHEPVGNSDKNPKQNSQSNRINDSNLRNTPXXXXXXXXXXXXXXXXXXXXXXXXXLPEFHGNVRQNSLNGRQSRRRPYDDDIDGSGAVISISESNVTETNGRNLDPVQLVRRRRQSTPISLSSRMNALIXXXXXXXXXXXXXXXXXXXXXXRGISEDRQRSNQLNSIFFEESDGDGNTIEGENDLDGDVDMEVYDEDHDTDIVPETEXXXXXXXXXXXCVTEYNPEPVNMTELTANRSIEQNTNSSLSVINMVDSGIRMKVDRPDAMETNIDNSETPSSNNNAENNSVRISIRKSANIIENKGDPDSSANDTSMRMSMEDNIRFSVVASSDLTRSNPETTQSVLVELVTPLASVPNLIPQPTLNNATEWFRNQVXXXXXXXXXXXXXXXXXXXXXXXXXXMNESATDLSQPIAQQTQRNISSNSTIPDNSANPDXXXXXXXXXXXXXXXXXXXXXXXXVQLARAFCCLIKLLAGLLNQMYYSREKNESVNQKEYDRFGLNLGQDNEYSSSCSPGATLSQSEEEHVMIESSQQLGPIWIWICQSMDFLESQVCFANAFQRKHGTYKARPVPTFEQVNTPNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLXXXXXXXXXXXLNSLRPTIGSECGDSILDEDTNCPTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQLPLHMGFSSRWADRLLDNNIIFSGVPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELLIMXXXXXXXXXXXXGISSRGSLYNRNEHNYIRMSAISRINTIAANTSSNISQTLNSIPSSSWYSDALSIIGMXXXXXXXXXXXXFRPAMRIISNPQTVQSNSSNIPSTRSIIRSDLSYTNTAHRLXXXXXXXXXXXXXXXNTSTSHVWGITXXXXXXXXXIPQSTSINFSHYNIDNMPLVSTPHRLDFSDRGISRRSINMASSRPPIXXXXXXXXXXXXXXXXXMGNNINXXXXXXXXXXXVTTRSVNSNTDMIYSNSQIPMXXXXXXXXXXNAQLGNIDPINLATGFTASLGNQAPIWVSSNWLPMYXXXXXXXXXXXXXXXXXRIQGFSPLHNQIPTSRHLEPSSIPTSSIANIQSNQNLNIYEMLRGKLPVNDPIYTMPASIRIPDIPTSSISSLPGTSGLSSIQNISIFDILRSRIPGDDSLIQQMAYNLTAISGRSDLNGLLNQLSLKNINMNDVINNLMNSMDQVPRFSDLHQSESAIVYSNIEGXXXXXXXXXXNIEVSIITFAIYLDXXXXXXXXXXXFSAAKSQPDDSSSLLPESHGPSTVLKTPSIDPEQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLTTSTESSQSKTFSSSRPTENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPDDWEEADDLLSLLDHADNPLLETAITDGTLGITEDIFPSIRLRRESLYSSMANDIESFADRRKRRRLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQRNKRNNNNANNKDTANIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCPQLNTSFLYGLLGSSNKSINIAENNQNTTDSINVTGSSSNYKMPTTWAEMPPPPSPASSTCSDQSGPVKISPGTFKRKKQSVNTSGTGDLVAEVNTESRPISNNNNRSNKIRCSDTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQP EEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNN+SSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETEWKLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSMNISSFPYRRWIDMGRPINDVNQFNYSRSNDRQASSVRFTVMSSSNTSRSSILTGDSNSGWLLPPIHLDEKEKRSNSYRIINIIINHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPAISIAANKNSISSMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLN RHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYSTNPDVDNRHEPVGNSDKNPKQNSQSNRINDSNLRNTPNISRRTSINNRNNGASDSNSSNGNNLPEFHGNVRQNSLNGRQSRRRPYDDDIDGSGAVISISESNVTETNGRNLDPVQLVRRRRQSTPISLSSRMNALIDEEDEDDGHSSGDDNWNSNNDSRGISEDRQRSNQLNSIFFEESDGDGNTIEGENDLDGDVDMEVYDEDHDTDIVPETESDSDDSISSSICVTEYNPEPVNMTELTANRSIEQNTNSSLSVINMVDSGIRMKVDRPDAMETNIDNSETPSSNNNAENNSVRISIRKSANIIENKGDPDSSANDTSMRMSM+DNIRFSVVASSDLTRSNPETTQSVLVELVTPLASV NLIPQPTLNNATEWFRNQVDLDAISDDESDDDESSQITEDDDQDDMNESATDLSQPIAQQTQRNISSNSTIPDNSANPDTQTNAQANTNSTTGNTTCGLQTTQVQLARAFCCLIKLLAGLLNQMYYSREKNESVNQKEYDRFGLNLGQDNEYSSSCSPGATLSQSEEEHVMIESSQQLGPIWIWICQSMDFLESQVCFANAFQRKHGTYKARPVPTFEQVNTPNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLVQEEVDDEQEDLNSLRPTIGSECGDSILDEDTNCPTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQLPLHMGFSSRWADRLLDNNIIFSGVPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELLIMNSSLSNQKKQSSGISSR               AISRINTIAANTSSNISQTLNSIPSSSWYSDALSIIGMNHNSSNNSSSRNFRPAMRIISNPQTVQSNSSNIPSTRS IRSDLSYTNTAHRLISAIAIFASSAPIVSNTSTSHVWGITSNSSNLNNSIPQSTSINFSHYNIDNMPLVSTPHRLDFSDRGISRRSINMASSRPPISST SVLSTSSFSSVSLMGNNINLPSSHLHSLPSVTTRSVNSNTDMIYSNSQIPMSIASESSISSNAQLGNIDPINLATGFTASLGNQAPIWVSSNWLPMYSNSASMSNSLTSLTNLSRIQGFSPLHNQIPTSRHLEPSSIPTSSIANIQSNQN+NIYEMLRGKLPVNDPIYTMPASIRIPDIPTSSISSLPGTSGLSSIQNISIFDILRSRIPGDDSLIQQMAYNLTAISGRSDLNGLLNQLSLKNINMNDVINNLMNSMDQVPRFSDLHQSESAIVYSNIEGSSETSQSTESNIEVSIITFAIYLDSLLNTNNSSSNFSAAKSQPDDSSSLLPESHGPSTVLKTPSIDPEQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV
Sbjct:    1 MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKALSQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKSVLDKIVYFGNANPSSRSNLTTSTESSQSKTFSSSRPTENSHGYIAQANSARNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEVPEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGGTSAPDDWEEADDLLSLLDHADNPLLETAITDGTLGITEDIFPSIRLRRESLYSSMANDIESFADRRKRRRLDCQLRNSADPLPRTFPDGTCVSRNGNESPTFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGMYSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSSGYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAPIFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNSGNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQRNKRNNNNANNKDTANIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSVRPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCPQLNTSFLYGLLGSSNKSINIAENNQNTTDSINVTGSSSNYKMPTTWAEMPPPPSPASSTCSDQSGPVKISPGTFKRKKQSVNTSGTGDLVAEVNTESRPISNNNNRSNKIRCSDTEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPQEEEEDWCLKDVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVFGNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPDIVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKCIEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGMIFNAERHRPIFLRDGNGTVYPLLFNESHSSNNLSSKFEPIPSPHWLDLPPVRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVLESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIHVAVNMCRPLSNVETEWKLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSMNISSFPYRRWIDMGRPINDVNQFNYSRSNDRQASSVRFTVMSSSNTSRSSILTGDSNSGWLLPPIHLDEKEKRSNSYRIINIIINHPCMENHLIGLLSQRNADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMIFPPAISIAANKNSISSMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECRTCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGDNSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSGRRHATSVLNTRHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFALNALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEVFLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKPPTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSVQPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQISDAVRNLDQIFYSTNPDVDNRHEPVGNSDKNPKQNSQSNRINDSNLRNTPNISRRTSINNRNNGASDSNSSNGNNLPEFHGNVRQNSLNGRQSRRRPYDDDIDGSGAVISISESNVTETNGRNLDPVQLVRRRRQSTPISLSSRMNALIDEEDEDDGHSSGDDNWNSNNDSRGISEDRQRSNQLNSIFFEESDGDGNTIEGENDLDGDVDMEVYDEDHDTDIVPETESDSDDSISSSICVTEYNPEPVNMTELTANRSIEQNTNSSLSVINMVDSGIRMKVDRPDAMETNIDNSETPSSNNNAENNSVRISIRKSANIIENKGDPDSSANDTSMRMSMDDNIRFSVVASSDLTRSNPETTQSVLVELVTPLASVSNLIPQPTLNNATEWFRNQVDLDAISDDESDDDESSQITEDDDQDDMNESATDLSQPIAQQTQRNISSNSTIPDNSANPDTQTNAQANTNSTTGNTTCGLQTTQVQLARAFCCLIKLLAGLLNQMYYSREKNESVNQKEYDRFGLNLGQDNEYSSSCSPGATLSQSEEEHVMIESSQQLGPIWIWICQSMDFLESQVCFANAFQRKHGTYKARPVPTFEQVNTPNISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLVDALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLVQEEVDDEQEDLNSLRPTIGSECGDSILDEDTNCPTLTCNYQSTNSSLLKPQINHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQLLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQLPLHMGFSSRWADRLLDNNIIFSGVPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTHFSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRNSTNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELLIMNSSLSNQKKQSSGISSR---------------AISRINTIAANTSSNISQTLNSIPSSSWYSDALSIIGMNHNSSNNSSSRNFRPAMRIISNPQTVQSNSSNIPSTRSNIRSDLSYTNTAHRLISAIAIFASSAPIVSNTSTSHVWGITSNSSNLNNSIPQSTSINFSHYNIDNMPLVSTPHRLDFSDRGISRRSINMASSRPPISSTVSVLSTSSFSSVSLMGNNINLPSSHLHSLPSVTTRSVNSNTDMIYSNSQIPMSIASESSISSNAQLGNIDPINLATGFTASLGNQAPIWVSSNWLPMYSNSASMSNSLTSLTNLSRIQGFSPLHNQIPTSRHLEPSSIPTSSIANIQSNQNINIYEMLRGKLPVNDPIYTMPASIRIPDIPTSSISSLPGTSGLSSIQNISIFDILRSRIPGDDSLIQQMAYNLTAISGRSDLNGLLNQLSLKNINMNDVINNLMNSMDQVPRFSDLHQSESAIVYSNIEGSSETSQSTESNIEVSIITFAIYLDSLLNTNNSSSNFSAAKSQPDDSSSLLPESHGPSTVLKTPSIDPEQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 3666

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Planmine SMEST
Match: SMESG000030063.1 (SMESG000030063.1)

HSP 1 Score: 106.301 bits (264), Expect = 2.272e-22
Identity = 86/315 (27.30%), Postives = 137/315 (43.49%), Query Frame = 2

Query: 10214 YRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFK---------KWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPM--------PTI----TIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGFV 11095
            +  +GRVIG+++     +    C+   K IL       DF   +  +Y SL  +                ++ + + +LN T    +E  G           +  I+L  NG  + V  N+  QY+++Y    +      Q +QIK G+Y+VLP+  L+ L+ ++  +LL G  EI +E                    +K T+ K         KWFW+VV ++   QR  LL F T S  +P S  GF+ +        P +     IR A+   LP A+TC +RL +P Y +   L +KL  AIE ++ GF 
Sbjct:  532 FHFIGRVIGMAIFHGYYIDADFCKIFYKSILNKQPQLEDFEELDKSIYNSLVWMR---------------DNNIDDADLNLTFSIEQEVFGQ----------LELIDLCENGRFIPVTDNSKSQYIERYVDYNLSEKCAEQYEQIKKGIYEVLPQQILDNLNEDEFEVLLTGISEIKIE------------------DWQKNTRLKHCLENEPLIKWFWEVVTSYTEQQRTKLLQFVTGSSRIPLS--GFEGLRGSYGSDEPKLFTIKVIRNANPLSLPKAHTCFNRLDLPPYPSYKCLHDKLTCAIE-ETCGFA 800

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BLAST of E3 ubiquitin-protein ligase UBR5 vs. Planmine SMEST
Match: SMESG000059703.1 (SMESG000059703.1)

HSP 1 Score: 92.8189 bits (229), Expect = 6.585e-18
Identity = 82/322 (25.47%), Postives = 135/322 (41.93%), Query Frame = 2

Query: 10160 PRRVNLNDNNQEYTRNN---IYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPM-----PT---ITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            P  V    N   Y  NN    ++ VGR I  ++  N+ +     R   K+ILG+ I + D    + Q +  L  L+K               + +    L+ T   +  E G   + D          LIPNG  + V   N  +YV+  C  +M   ++ QL     G Y+++PK+ ++  + ++L LL+ G  EI++          D    T+ N     +   +WFWQ + +F+   R   + F T +  +P    GF  +     PT   I++      HLP A+TC + + +P Y     L + LL AI   S G+
Sbjct: 3778 PDGVTYTINPASYVNNNHLSYFKFVGRFIAKAIFDNKLLTCYFTRAFYKHILGISIRYTDLEKEDYQFFRGLEFLLK---------------NDVSTMFLDQTFSIQISEFGQTETRD----------LIPNGSQILVTEENKSEYVRLVCQEKMTGAIRQQLHSFLEGFYEIIPKNLISIFNEKELELLICGLPEIDLN---------DLKINTVYNKYTPASPQIQWFWQALESFDQEDRARFIQFVTGTSKVPLG--GFSKLEGMNGPTKFQISLASMSTNHLPAAHTCFNSIDLPQYENFDKLHKCLLTAIRECSEGY 4063

[Close]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Planmine SMEST
Match: SMESG000059703.1 (SMESG000059703.1)

HSP 1 Score: 92.8189 bits (229), Expect = 6.925e-18
Identity = 82/322 (25.47%), Postives = 135/322 (41.93%), Query Frame = 2

Query: 10160 PRRVNLNDNNQEYTRNN---IYRSVGRVIGISMLMNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQLMGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGEDVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSPEDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVVMAFNSIQRQNLLYFWTSSPALPASNQGFQPM-----PT---ITIRPADDFHLPTANTCISRLYIPLYSTKIILREKLLQAIETKSFGF 11092
            P  V    N   Y  NN    ++ VGR I  ++  N+ +     R   K+ILG+ I + D    + Q +  L  L+K               + +    L+ T   +  E G   + D          LIPNG  + V   N  +YV+  C  +M   ++ QL     G Y+++PK+ ++  + ++L LL+ G  EI++          D    T+ N     +   +WFWQ + +F+   R   + F T +  +P    GF  +     PT   I++      HLP A+TC + + +P Y     L + LL AI   S G+
Sbjct: 3780 PDGVTYTINPASYVNNNHLSYFKFVGRFIAKAIFDNKLLTCYFTRAFYKHILGISIRYTDLEKEDYQFFRGLEFLLK---------------NDVSTMFLDQTFSIQISEFGQTETRD----------LIPNGSQILVTEENKSEYVRLVCQEKMTGAIRQQLHSFLEGFYEIIPKNLISIFNEKELELLICGLPEIDLN---------DLKINTVYNKYTPASPQIQWFWQALESFDQEDRARFIQFVTGTSKVPLG--GFSKLEGMNGPTKFQISLASMSTNHLPAAHTCFNSIDLPQYENFDKLHKCLLTAIRECSEGY 4065

The following BLAST results are available for this feature:

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Human
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Celegans
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Fly
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Zebrafish
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Xenopus
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Mouse
BLAST of E3 ubiquitin-protein ligase UBR5 vs. UniProt/SwissProt
BLAST of E3 ubiquitin-protein ligase UBR5 vs. TrEMBL
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Cavefish
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Sea Lamprey
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Yeast
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Nematostella
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Medaka
BLAST of E3 ubiquitin-protein ligase UBR5 vs. Planmine SMEST

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
UBR5	9.619e-96	49.08	ubiquitin protein ligase E3 component n-recognin 5...	[more]
UBR5	1.493e-89	39.68	ubiquitin protein ligase E3 component n-recognin 5...	[more]
UBR5	1.515e-89	39.68	ubiquitin protein ligase E3 component n-recognin 5...	[more]
UBR5	1.532e-89	39.68	ubiquitin protein ligase E3 component n-recognin 5...	[more]
UBR5	2.656e-37	56.00	ubiquitin protein ligase E3 component n-recognin 5...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ubr-5	5.632e-62	39.51	UBR E3 ubiquitin ligase homolog [Source:UniProtKB...	[more]
ubr-5	5.632e-62	39.51	UBR E3 ubiquitin ligase homolog [Source:UniProtKB...	[more]
eel-1	3.396e-23	25.41	Enhancer of EfL-1 mutant phenotype [Source:UniPro...	[more]
eel-1	3.482e-23	25.41	Enhancer of EfL-1 mutant phenotype [Source:UniPro...	[more]
eel-1	3.601e-23	25.41	Enhancer of EfL-1 mutant phenotype [Source:UniPro...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hyd	1.160e-89	51.38	gene:FBgn0002431 transcript:FBtr0082090	[more]
hyd	1.470e-89	51.38	gene:FBgn0002431 transcript:FBtr0339599	[more]
HUWE1	9.617e-25	28.00	gene:FBgn0030674 transcript:FBtr0340304	[more]
HUWE1	9.937e-25	28.00	gene:FBgn0030674 transcript:FBtr0339688	[more]
HUWE1	1.003e-24	28.00	gene:FBgn0030674 transcript:FBtr0339686	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ubr5	1.108e-88	40.08	ubiquitin protein ligase E3 component n-recognin 5...	[more]
hace1	1.235e-19	25.82	HECT domain and ankyrin repeat containing E3 ubiqu...	[more]
smurf2	1.786e-16	25.50	SMAD specific E3 ubiquitin protein ligase 2 [Sourc...	[more]
hecw2a	4.092e-16	25.24	HECT, C2 and WW domain containing E3 ubiquitin pro...	[more]
hecw2a	4.096e-16	25.24	HECT, C2 and WW domain containing E3 ubiquitin pro...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
UBR5	2.993e-89	39.68	ubiquitin protein ligase E3 component n-recognin 5...	[more]
UBR5	3.238e-89	39.68	ubiquitin protein ligase E3 component n-recognin 5...	[more]
UBR5	3.361e-89	39.68	ubiquitin protein ligase E3 component n-recognin 5...	[more]
UBR5	3.420e-89	39.68	ubiquitin protein ligase E3 component n-recognin 5...	[more]
UBR5	3.608e-89	39.68	ubiquitin protein ligase E3 component n-recognin 5...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ubr5	3.155e-90	39.88	ubiquitin protein ligase E3 component n-recognin 5...	[more]
Ubr5	3.630e-90	39.88	ubiquitin protein ligase E3 component n-recognin 5...	[more]
Hace1	2.051e-20	25.74	HECT domain and ankyrin repeat containing, E3 ubiq...	[more]
Huwe1	5.732e-20	25.33	HECT, UBA and WWE domain containing 1 [Source:MGI ...	[more]
Huwe1	6.181e-20	25.33	HECT, UBA and WWE domain containing 1 [Source:MGI ...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O95071\|UBR5_HUMAN	7.358e-89	39.68	E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens O...	[more]
sp\|Q62671\|UBR5_RAT	7.898e-89	39.88	E3 ubiquitin-protein ligase UBR5 OS=Rattus norvegi...	[more]
sp\|P51592\|HYD_DROME	1.163e-88	51.38	E3 ubiquitin-protein ligase hyd OS=Drosophila mela...	[more]
sp\|Q80TP3\|UBR5_MOUSE	2.750e-88	39.68	E3 ubiquitin-protein ligase UBR5 OS=Mus musculus O...	[more]
sp\|P51593\|HUWE1_RAT	1.599e-20	25.33	E3 ubiquitin-protein ligase HUWE1 (Fragment) OS=Ra...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0X3PZ81	5.089e-98	34.68	Uncharacterized protein (Fragment) OS=Schistocepha...	[more]
A0A0X3NHL3	4.460e-98	34.68	E3 ubiquitin-protein ligase UBR5 (Fragment) OS=Sch...	[more]
A0A0X3NNM2	5.132e-98	34.68	Uncharacterized protein (Fragment) OS=Schistocepha...	[more]
A0A5K3FGH2	4.900e-31	34.37	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A5K3FCE0	2.652e-98	34.40	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ubr5	5.448e-91	39.44	ubiquitin protein ligase E3 component n-recognin 5...	[more]
hace1	2.544e-20	25.82	HECT domain and ankyrin repeat containing E3 ubiqu...	[more]
hace1	3.277e-20	25.82	HECT domain and ankyrin repeat containing E3 ubiqu...	[more]
hecw2a	6.903e-17	26.20	E3 ubiquitin-protein ligase HECW2-like [Source:NCB...	[more]
smurf1	1.611e-16	25.17	SMAD specific E3 ubiquitin protein ligase 1 [Sourc...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000002570.1	8.815e-92	40.08	pep scaffold:Pmarinus_7.0:GL481077:241:22857:1 gen...	[more]
ENSPMAT00000002561.1	3.565e-88	38.76	pep scaffold:Pmarinus_7.0:GL481077:241:24166:1 gen...	[more]
ube3a	3.376e-14	25.26	ubiquitin protein ligase E3A [Source:ZFIN;Acc:ZDB-...	[more]
wwp2	2.638e-13	29.95	WW domain containing E3 ubiquitin protein ligase 2...	[more]
nedd4a	4.102e-13	24.49	NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;A...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
RSP5	5.917e-18	23.18	NEDD4 family E3 ubiquitin ligase; regulates proces...	[more]
TOM1	1.009e-16	25.08	E3 ubiquitin ligase of the hect-domain class; has ...	[more]
HUL5	4.253e-16	26.80	Multiubiquitin chain assembly factor (E4); proteas...	[more]
UFD4	1.393e-11	26.52	Ubiquitin-protein ligase (E3); interacts with Rpt4...	[more]
HUL4	9.573e-10	22.93	Protein with similarity to hect domain E3 ubiquiti...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO37117	2.400e-52	34.67	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34473	5.815e-18	28.43	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO46071	2.666e-16	26.40	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49383	2.855e-16	25.72	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40302	1.482e-15	25.62	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ubr5	1.788e-88	39.40	ubiquitin protein ligase E3 component n-recognin 5...	[more]
ubr5	1.826e-88	39.40	ubiquitin protein ligase E3 component n-recognin 5...	[more]
ubr5	1.841e-88	39.40	ubiquitin protein ligase E3 component n-recognin 5...	[more]
huwe1	4.878e-19	24.67	HECT, UBA and WWE domain containing E3 ubiquitin p...	[more]
hace1	6.729e-19	25.08	HECT domain and ankyrin repeat containing E3 ubiqu...	[more]

BLAST of E3 ubiquitin-protein ligase UBR5 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000050687.1	0.000e+0	99.78	SMESG000050687.1	[more]
SMESG000050687.1	0.000e+0	99.38	SMESG000050687.1	[more]
SMESG000030063.1	2.272e-22	27.30	SMESG000030063.1	[more]
SMESG000059703.1	6.585e-18	25.47	SMESG000059703.1	[more]
SMESG000059703.1	6.925e-18	25.47	SMESG000059703.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30008783 ID=SMED30008783|Name=E3 ubiquitin-protein ligase UBR5|organism=Schmidtea mediterranea sexual|type=transcript|length=11230bp
TTTTCATTCAATTTATTTACATTTATAGAAATTTACAATATTTTAATGTG
AAATGTCAATTATATTTCATTTCGTTGATAATCAGTCTCATAATGGGCAA
ACTTTACAATATATTCAAGCTGAATTGTATGAAAGACTAAAGGAATTTTC
TGAACAAATAAAGGAAGATGGTGTATATCACCAAAATTCTTTAAAAGCTC
TTTCACAATACGTCATTGAGGAAGTTGTTGTAGGAACAAATGCTTTAGCT
TTTCGTCTTCAAGACGGTAGAGTTTGTCGAACGAATTTTACTATTAAAAC
AGAAAAACCTCTTCAAAAACAAGAAAAAGTGCAAAAGCGTATATCTAAAA
GTGTTTTGGATAAAATAGTTTATTTTGGCAATGCAAATCCGTCATCACGA
TCTAATTTGACAACATCTACAGAATCATCACAGTCAAAAACATTTAGTTC
TTCAAGACCAACCGAAAATTCTCATGGTTATATTGCACAAGCTAATTCAG
CTAGAAACAGTTTACCTCACAGAATTGCTAGATATCAAATGCTTTCTTCA
AGTCACACATCAGCACCAAGAGTTAATTTCATTAGAGAAATGCAACGACA
AGGAATTTATTTCGCTAGAACATTTCCAACTCCAATTGCTGCCAGCGAAG
TTCCAGAAGATTTAATTGAACAGTGTCAAACTGTATTGCAAGGAAAATCA
CGTCAATTAATTATACGAGAATTACAGCGAACTAATCTTGATGTAAACAT
GGCAGTCAACAATTTATTATCACGTGATGACGAAGCTGAAGAAAACGGGG
GAACATCAGCTCCAGATGATTGGGAGGAAGCCGATGACTTATTATCATTG
CTCGATCACGCCGATAATCCGCTACTAGAAACTGCAATCACCGATGGAAC
GCTGGGAATCACCGAAGATATTTTCCCCAGTATTCGATTGCGTCGAGAAT
CCCTTTATTCATCAATGGCCAATGATATAGAATCGTTTGCGGATCGACGC
AAGCGGCGCCGATTGGATTGTCAATTGCGCAACTCAGCTGATCCATTACC
TCGCACTTTTCCGGATGGTACATGTGTATCCAGAAATGGCAATGAATCGC
CGACGTTTTCACCGGATGATTGTGGAAAAAATGAATCAACACCGGTGAAG
AAAAATTGTTTAGTTCTGGGACCCAATTTAGAATTTTGGAAAGAAAAATT
AAAAGACAATGGAAAAGTTAAAGATATAAAATTTATCAAAATCGCGGGAA
TGTATTCGGAATTAATCGGAATCACAACCGATAACGATTTACATCAATGG
CGATGGTGTGACTCTGAACCGTGGAGTAGTGTAGGTGATTCCAGTAATTC
CACCGTTCTTCAAAATTCAAATATCTGGGGTAACTCCATTCCGAATTCAT
CGGGATATTTAGGAGCTTACTATCATACCAGAATTCCAAGTTTAAATCTT
TTCGGGGAGAAAATTATAAAACTGAGTGCGTGTTCCAGTCGCGCTACCGT
ATTAACTGCCAGTGGAAAGTTGGCAACATGGGTCGATGAGACGATAGCAC
CGATTTTTCAAGTTTTGAGAAATTCGGATCAAAATTTCACCACACAAAAC
CTTCGGATAGAACATCCAGTTATGCAGTTTTCTGAATTGAAAGATGAAAC
GATATTTGAATTATTCACTTCAACTCTGGTCTCAGCGGTCCGATGTAATT
CTGGTAATATTTACTGGTGGGGTGTCATTCCTTTCAAATATCGAAAAAGT
GCCATGGAAAAAAATAGAGACCGAACACCAAAAACGGAAGTTAAATACAA
TGGTCAGCGCAACAAACGAAATAATAATAATGCCAACAACAAGGACACTG
CAAATATTGTCCCTGGCTCATTTGTTTGTATGAAGAACGCTCCAATATTC
CACGCTGGAGCAATTGGATTTACTGTCATAGGAGGTGTTCCTAAAATAGG
AACACTACTTGAAGATGCATGGAAGATTGAGGATATTTGTCGATTCAGTG
TGAGACCGGTTCAAAGCTTAGTCAACGAAAGAAGGAATTGTCTACCTAAT
TCCGTCCAATCTATAAATCCAGCCTCGTTTGATCCTTTAACTCATGCTCA
CATGTGTCCCCAGTTGAATACTTCTTTCCTATATGGACTTCTAGGAAGTA
GTAATAAATCGATAAACATTGCGGAGAATAACCAGAATACCACTGACAGC
ATTAATGTAACAGGATCGAGCAGTAATTATAAAATGCCAACAACATGGGC
GGAAATGCCTCCACCACCTTCTCCAGCTAGTTCTACATGTAGTGATCAAA
GTGGACCTGTTAAAATCAGCCCAGGAACATTTAAAAGAAAAAAGCAATCA
GTTAATACCTCGGGCACTGGTGATTTAGTTGCAGAAGTTAATACCGAGAG
TCGTCCTATTTCTAATAATAACAATAGATCGAATAAAATACGATGCAGTG
ATACTGAAAAATCGAATGCTTTACCAATGAATACAGATTATGAACCATTA
GCAGGTCATAAAAGACCATTAACCCCAGATGATAAGTCAAATGGTTCTAC
TGGTTTACCCCAAATGCAACCACACGAAGAAGAAGAAGACTGGTGCTTGA
AAGACGTAATATTTCTCGAAGACGGCCGTACTCAGCCGGTGGGAGTGGTT
TTGAAAGTCGACGGTTCAATTGCCGCTGTAAAGTTCTTGAAAGATTCTGA
AAGAGCATGTGTTGCGGTCAATTGTTTATATTCACCATTAGCCGCTGTAT
TTGGAAATAATAACAATGCGTGCTCAGAGACTTCTATAAATTCTACAACA
CCGAACTCTCCAGATCCAATTTCATGGCTCAATGATTGTAGATTATTACG
AAAAGAAGAGTTAGTGGTTGTCAAACAACCACTGGTGTCCAGAGTTCCAG
ATATCGTTCAAAAACACCCGAAATGCATTCCTACTGAAGTATTCCTTGAA
GCTAAACCGACAACATTGTCTCCATGTTTCGGAATATTGGGAATGGCAGT
AGAAAATGAATTAATTCACTTATTGGTTAGAAAATCCACTAGTTCCAAGT
GCATCGAGTACAAGTTGTTAAGTTTGGGCAAAAAAGTTATTTCATCTCAT
CGATTAAATACGTCTGCTAACGGATTTCTAGGGCGTGCTCCTCAACCGTG
TTTAATAGCCAGTCCATTAGAAAGCGAATATTCAGAATTAAAAAATGGAA
TGATTTTCAATGCCGAAAGACATCGTCCAATATTTCTAAGAGATGGAAAT
GGAACGGTTTATCCTTTGCTGTTCAATGAATCTCACAGCAGCAATAACAT
GTCATCGAAATTTGAGCCTATTCCCAGTCCGCACTGGCTGGATTTGCCAC
CTGTAAGATGTGTCGATTTCGGATTTGTTAACGTCAACAATTACAATATC
AAATCTCCAATAATTCCCGGATCCAACAGCAATTCAACAAATGATACACA
CAAAAATTCCAAAAGCAAGTTCAATAGATTGCTTGTCGGAGTTCTGGTTT
TGGAATCTCAGACATTGATGCATCACATTCTTCGCACTGATGACAAGAAG
GTTTCAAATGTAATGGATAATTTCGCAGTGGGTTCGGAGTATGATGGATT
TGTACAGAGAATAATAAGTGAGAAATTGGACGGTCAACGTAATATAATAC
ATGTCGCTGTGAATATGTGCCGACCATTGTCCAATGTTGAAACCGAATGG
AAATTATCAAATATTCTTAATTATCGATCCAAGAAATCATCCACAAACAC
AAATGTCGAAGATTTATCTCAACGATCCAATTGGTCTTTAGAGCATTCAA
TGAATATTTCTTCTTTTCCCTATCGTCGATGGATTGACATGGGTCGACCA
ATCAACGATGTTAATCAATTTAATTACTCTCGCTCAAATGACCGACAGGC
TAGTAGCGTCAGATTTACAGTAATGAGCTCATCGAATACCTCAAGAAGTT
CCATTCTCACTGGAGATTCTAATTCTGGATGGTTGTTACCGCCAATTCAT
TTGGATGAAAAAGAAAAGCGATCAAATAGTTATCGAATCATTAATATTAT
TATAAATCATCCGTGCATGGAAAATCATTTGATTGGTTTATTGTCTCAAA
GAAATGCCGATGGCCAGACTCCATTTATGCAGTCAGTCTCACAACGAATA
TATCCATTGGCTCTATTTCTTCTCGATTGTATTATGGATCTATGCGATAT
GCAATATGTATCGGTTCTGAATTCCAAAAGCCAGTTAGCTTTAAGCATGA
TTTTTCCTCCTGCCATCAGTATAGCTGCCAATAAAAATTCTATATCTTCT
ATGTATGAAGACAATCCATTACAAGTATTGTGCCAGAATGATGGCTGTAG
TTTCACCTGGACTGGTCCTGATCATATCCGTCAGGATATATTCGAATGCC
GGACGTGTGGTTTAACGGAATCGCTTTGTTGTTGCACCGAGTGTGCCCGT
GTTTGTCACAAAGGACATGATTGTCATTTAAAGAAAACTTCACCGACTGC
GTATTGTGATTGTTGGGAAAAATGTCGCTGTAAAGCTCTCATTGTAGGAG
ATAATTCGGCAAGACAGGAATTATTAAAGAAACTTCTACAACATACAGAT
CTGGCCACTTTGCCAAATAGAAGAAAAGAACATCTTTTGCTGTTCCTTGT
CAAAACGGTTGATAGACAATTTAGAGAACATAAGCAAATTAGAACATCTG
GCCGTAGACACGCAACATCGGTTTTAAATGCTCGTCATGGCAATAACGTT
AATTTCACAGCTTCTTCTCATGTTTCGTTGTTGGAGCCTCATCACCCAGC
TTATGAACCTCCTATGCCAGAGTATGGCTTAGAACCATCAAATTTCGCAC
TAAATGCATTAGATGCCGTACTATCTAATTGGCCGTCTGTTGAAACGTTA
CTTTTATCAGGCGATAGATCTGATTGGGTAAATAATCTGGTTAAAAATAT
GGATTCGTCTTCAAGAAATGATGGAATTAATCCTTTGACAGATGATGAAG
TTTTCCTCAACTATCAGAGCTTTTCGGAACAACTCGATCAATTTGTGTTC
ACATTAATTGCAAAAACAGCATCTTCATCGGTCGATATTCTGTTAAACAC
TTTGAATAAAGAACTGCAAAATGAAAAATCGCATCCACTAACAATGAAAC
CACCAACACAAACTAAAGTGAAAACTGCAGCAGCTAGATTGATTAGATCA
GTTGCAAGAGTTTTTGTTGCTCTTCAGTTGCAAATGGCTCCAGATTTCAA
CAGAAAACGTCAATCCAATCGTTTGAGTAACAGTGTTCATGTTTATTCCG
TTCAACCGAAACCATTGGACGTTTGCAAGAGAATTTTTGAAAATCTACTA
TTCGTATCGTTATCTGAGTTGCCACGAATCGCTGCAGATATAATAGCTCC
GGTGAGATGTGGTTTATTGAAGCCTACGGCAAACTACGCTCATTTCTATC
AAATATCCGATGCCGTCAGGAATCTGGATCAAATATTTTATTCAACTAAT
CCCGATGTGGATAATAGACACGAACCAGTTGGAAATTCCGATAAAAATCC
TAAACAAAATTCTCAGTCTAACCGCATTAATGATAGCAATTTAAGAAATA
CCCCAAATATTTCCAGACGAACTAGCATTAATAATAGAAATAACGGAGCA
TCTGATTCTAATTCTTCAAATGGTAATAATCTGCCGGAATTCCATGGAAA
TGTTCGACAAAACAGCCTTAATGGACGCCAGAGTCGCCGTAGACCTTATG
ATGATGATATAGATGGTTCAGGAGCAGTCATTTCTATTTCGGAATCAAAT
GTCACCGAAACCAATGGTCGCAATTTAGATCCAGTACAATTAGTTAGGCG
ACGTAGACAATCTACACCAATAAGTCTAAGTAGTCGAATGAATGCTTTAA
TTGATGAGGAAGACGAGGATGATGGTCATTCATCTGGAGATGATAACTGG
AATTCAAATAATGATTCTAGAGGAATTTCCGAAGATAGACAGCGCTCCAA
TCAATTGAATAGCATTTTCTTTGAAGAGTCTGATGGCGATGGTAATACAA
TCGAAGGGGAAAACGATTTGGACGGCGATGTAGATATGGAAGTGTATGAT
GAAGACCACGATACTGACATCGTTCCAGAAACCGAATCAGACAGTGATGA
CTCTATCAGTAGTAGTATTTGCGTGACGGAATACAATCCTGAACCGGTCA
ATATGACAGAATTAACCGCCAATAGATCAATTGAGCAAAATACAAATTCT
TCATTATCGGTAATCAACATGGTCGATTCAGGCATAAGAATGAAAGTTGA
TAGACCCGACGCAATGGAAACAAACATCGATAATTCAGAAACTCCATCTT
CTAATAATAATGCTGAAAATAACTCCGTAAGAATATCGATAAGAAAATCT
GCCAATATAATTGAAAATAAAGGCGATCCGGATTCATCTGCAAATGATAC
CTCTATGCGCATGTCTATGGAGGATAATATCAGATTTTCAGTTGTAGCGA
GCTCAGATTTAACGAGATCAAATCCTGAAACTACTCAGTCTGTTTTAGTG
GAATTGGTTACTCCTTTAGCATCAGTGCCCAATCTAATCCCACAGCCGAC
TCTCAATAATGCCACTGAATGGTTTCGTAATCAGGTAGACTTAGATGCCA
TAAGCGATGATGAATCCGATGACGACGAATCCTCGCAAATTACCGAGGAT
GACGACCAAGATGATATGAATGAATCTGCAACGGATCTATCTCAACCGAT
TGCTCAACAAACACAAAGAAATATTTCATCAAACTCGACAATTCCCGATA
ATTCAGCTAATCCTGACACCCAAACCAATGCCCAGGCAAATACCAATTCC
ACGACTGGAAATACTACATGTGGCTTGCAAACAACTCAAGTTCAATTGGC
CCGGGCTTTCTGTTGTCTCATTAAATTGTTAGCAGGCTTACTTAATCAAA
TGTATTATTCACGTGAAAAAAATGAATCTGTCAACCAAAAGGAATATGAC
AGATTTGGATTAAATCTCGGTCAAGATAATGAATACTCTAGTTCTTGTTC
TCCTGGTGCAACTTTGAGTCAATCAGAAGAGGAACATGTAATGATTGAAT
CATCTCAACAATTAGGACCAATTTGGATTTGGATTTGTCAGTCAATGGAC
TTTCTAGAGTCGCAAGTATGTTTTGCAAACGCTTTTCAACGGAAGCACGG
AACCTATAAAGCTCGTCCAGTTCCTACTTTTGAACAAGTTAACACTCCGA
ATATTTCATCAGCACCTTCATCCGGTGATGCAAATCGTGCTGATTTCCTT
AGATATGTAGTCAGCATGATGAGAGCAAGTTCTGATGAACATGGCGACCA
AACACCAACCAGTCTTAACGCAGTTAATTACTGCCATTTGGCATATCTTG
TCGATGCTTTGCTGTATTTGATGCGTATTTGTTTCGGCATGGTAACGGAT
AAAGTATGCTGTGATGGTGTCGATCCTTCCGGCCCATCAATTGAAGATTG
TGTTACTGCTGTTAATGATCATCTAAAACGAGAACCTACACTAGTTCAAG
AAGAGGTTGATGATGAACAAGAAGATCTAAATAGTTTAAGGCCCACTATT
GGATCTGAATGTGGGGATAGTATTTTAGATGAAGATACGAACTGCCCCAC
TTTGACTTGTAATTATCAGTCCACAAATTCTTCTTTATTGAAACCTCAAA
TTAATCATAGAAGAGATTGTCAACAAAAAATCGATACTTCCGAGGATAGT
TTTTTTTGTCGTACTGATTATCCGCAAGGTTGGGTAGGTCTAGGGGCTGA
TTCTTTCCAAACTCCTGTATCAGAATCACTACCATTAGCATATATGCCAC
AGTTGTTACAGCCTCCTGGACCGACAGATGAAGTGTTTGGAGTTTTGAGA
CGATTCGAAATCGATCGAAATACTATTAACAACCAAAATTTCTGTGGTAG
AAGTAATGAAGGACAACTACCACTTCATATGGGGTTCTCAAGTCGTTGGG
CCGATCGCTTATTAGATAACAACATCATCTTTAGTGGAGTTCCTGTAGGA
AACTTGAGAACAAGGTGGCGTTATTCTTTGGAATTGTTATCAAATTCATT
CGAACAAAATGTTGGACTAGAACCTGGCAGTGTTTTAGTTGATTTCACAC
ATTTTAGCTTGAAAGAAACGAGATTTCGTAAAGAAATGGAAAAATTACGA
AATCAATGTCGACGTGATCTATCTCTCATTGTTAATAGGGAACGTAATTT
AATCATATGTGATACCGTGACCCAATTGAATACTGAATATTCAAGACGTA
ATTCAACTAATACACAAAATCCTTTGATGTGTCATAGATTTAAAGTTAAA
TTTAATGATGAACCTGGAGAAGGAAATGGAGTAGCAAGGAGTTTCTTAAC
AGTTTTTGCTGAAGCGGTCCTATCAGAAGAATTGTTAATAATGAATTCTT
CTTTAAGCAATCAAAAGAAACAATCATCAGGAATATCTTCTAGAGGTTCG
CTTTATAATCGAAATGAACATAATTACATTAGAATGTCAGCTATATCAAG
AATTAATACCATTGCCGCAAATACTTCATCGAATATTTCTCAAACTTTAA
ATTCGATTCCGTCAAGTAGTTGGTATAGTGATGCCCTTTCAATTATTGGA
ATGAATCATAATAGCTCTAATAATTCTTCGTCTAGGAATTTCCGACCAGC
TATGCGAATTATTTCTAATCCTCAGACAGTTCAATCGAATTCTTCGAATA
TTCCCAGTACTAGATCAATTATTAGATCAGATCTTTCTTACACAAATACA
GCACATAGGCTTATATCTGCTATTGCCATTTTTGCCTCCTCTGCTCCCAT
TGTTTCTAATACTTCTACTTCACATGTATGGGGTATTACCAGCAATTCAT
CTAATCTTAATAATTCTATTCCTCAGTCGACTAGTATTAATTTCTCTCAT
TATAATATTGATAATATGCCTTTGGTTTCTACTCCTCATAGGCTTGATTT
TTCGGATAGAGGCATTTCAAGAAGGTCAATCAATATGGCTTCTTCAAGAC
CTCCAATATCATCCACAGCTAGTGTTTTATCAACATCTTCTTTCAGTTCT
GTTTCTCTCATGGGGAATAATATTAATCTTCCATCATCACATCTCCATTC
ACTACCAAGCGTAACTACAAGATCAGTTAATAGTAATACAGACATGATTT
ACAGTAATTCTCAAATTCCAATGTCAATAGCTTCAGAATCAAGTATTTCT
TCAAATGCTCAATTGGGAAATATAGATCCCATAAATTTAGCAACAGGGTT
CACAGCTAGTCTTGGTAATCAAGCACCGATATGGGTCAGTTCTAATTGGT
TACCTATGTATTCAAATTCAGCATCAATGTCAAATTCTCTGACATCCCTT
ACCAATCTTAGTCGAATTCAAGGATTCTCACCTTTACATAATCAAATCCC
AACAAGTCGTCATTTGGAGCCATCGAGTATACCCACATCATCAATCGCCA
ATATCCAATCAAATCAAAATTTAAATATCTATGAAATGTTACGTGGAAAA
CTTCCAGTAAATGATCCAATTTATACTATGCCAGCATCAATTAGAATACC
CGATATACCTACCAGCTCGATTTCAAGCTTACCCGGAACATCGGGGCTTT
CATCAATTCAAAATATCAGTATCTTTGATATATTACGCAGTAGAATACCG
GGTGATGACTCACTAATCCAGCAAATGGCATATAATCTTACCGCCATATC
AGGTCGATCAGATCTTAATGGATTGCTAAATCAGTTGTCTCTGAAAAATA
TTAACATGAATGATGTTATTAACAATTTAATGAATTCCATGGATCAAGTT
CCGAGATTTTCAGATTTACACCAATCAGAATCAGCAATTGTATATAGCAA
TATTGAAGGATCATCTGAAACATCACAGTCAACAGAAAGCAATATAGAAG
TGTCAATAATCACATTTGCAATTTACCTTGACAGTTTATTAAACACAAAT
AATAGCAGCTCCAATTTTAGTGCTGCAAAATCCCAACCAGATGATTCAAG
CTCTTTGTTACCCGAGTCTCATGGACCGAGTACGGTTCTCAAAACTCCCT
CTATAGATCCCGAACAAACGCCTCTATTTTGGCAACCTGGACATCCAGGA
TTCTATTGTCCACGCCGAGTAAATCTTAATGATAATAACCAAGAATATAC
TCGGAATAACATTTATCGATCGGTTGGAAGAGTCATAGGCATATCAATGT
TAATGAATGAAACAATGCCGTTAAAACTATGTCGACATGTTCTCAAATAT
ATTCTTGGTCTACCGATTGGATGGCATGATTTTGCATTTTTTAATTCCCA
ACTCTACGAAAGCCTGAGACAATTAATGAAAGTGGCTCGCGAAGCTCAAT
TAATGGGTATTGCAGGAGCTCCCGAAGATCCATTGTTAGAATATAATTTG
AATTTCACAATTGTACCGAGAGAAGAAGAAGGTGGTAATGGAAATTCTGG
AGATAGAAAAGTTATTGGAATGAACAGTATTAATTTGATTCCAAATGGTG
AAGATGTCGATGTTGACTCGAATAATGTTTTCCAATACGTCAAGAAATAT
TGTATCACTCGAATGATAACAATTGTGAAACCTCAATTAGATCAAATTAA
AAATGGTGTTTACGATGTTCTGCCAAAGCATGCACTCAACGGATTATCTC
CTGAAGATTTACGACTTCTGCTTAATGGAACTGATGAGATTAATGTTGAA
GTCTTGATCAGTTACACTTCGTTTCTCGACGAATCTTCCTGTACAATTTC
TAATTCGCAAGAAAAAGTAACAAAATTCAAAAAATGGTTCTGGCAAGTTG
TCATGGCATTTAACAGCATACAGCGACAGAATTTACTCTATTTTTGGACC
TCAAGTCCCGCATTGCCTGCAAGCAATCAAGGATTTCAACCGATGCCTAC
CATAACGATCAGACCGGCAGATGATTTCCATTTGCCAACAGCCAACACGT
GTATATCCAGATTATACATTCCTTTATATTCTACGAAAATAATTTTACGA
GAAAAATTATTACAAGCTATTGAAACTAAAAGTTTTGGATTTGTTTAAAA
TATATTCATTGACTTTTTCAATGGTTTTGCGGTTGAATTTTCCCGTATTT
TTGCAATTGATTTTTTGTTTTAGTCCATTTGTAAATAGATATTTATTTAT
ATAGATCACAATAACTTTGATCGAGTTTCT

protein sequence of SMED30008783-orf-1

>SMED30008783-orf-1 ID=SMED30008783-orf-1|Name=SMED30008783-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=3682bp
MSIIFHFVDNQSHNGQTLQYIQAELYERLKEFSEQIKEDGVYHQNSLKAL
SQYVIEEVVVGTNALAFRLQDGRVCRTNFTIKTEKPLQKQEKVQKRISKS
VLDKIVYFGNANPSSRSNLTTSTESSQSKTFSSSRPTENSHGYIAQANSA
RNSLPHRIARYQMLSSSHTSAPRVNFIREMQRQGIYFARTFPTPIAASEV
PEDLIEQCQTVLQGKSRQLIIRELQRTNLDVNMAVNNLLSRDDEAEENGG
TSAPDDWEEADDLLSLLDHADNPLLETAITDGTLGITEDIFPSIRLRRES
LYSSMANDIESFADRRKRRRLDCQLRNSADPLPRTFPDGTCVSRNGNESP
TFSPDDCGKNESTPVKKNCLVLGPNLEFWKEKLKDNGKVKDIKFIKIAGM
YSELIGITTDNDLHQWRWCDSEPWSSVGDSSNSTVLQNSNIWGNSIPNSS
GYLGAYYHTRIPSLNLFGEKIIKLSACSSRATVLTASGKLATWVDETIAP
IFQVLRNSDQNFTTQNLRIEHPVMQFSELKDETIFELFTSTLVSAVRCNS
GNIYWWGVIPFKYRKSAMEKNRDRTPKTEVKYNGQRNKRNNNNANNKDTA
NIVPGSFVCMKNAPIFHAGAIGFTVIGGVPKIGTLLEDAWKIEDICRFSV
RPVQSLVNERRNCLPNSVQSINPASFDPLTHAHMCPQLNTSFLYGLLGSS
NKSINIAENNQNTTDSINVTGSSSNYKMPTTWAEMPPPPSPASSTCSDQS
GPVKISPGTFKRKKQSVNTSGTGDLVAEVNTESRPISNNNNRSNKIRCSD
TEKSNALPMNTDYEPLAGHKRPLTPDDKSNGSTGLPQMQPHEEEEDWCLK
DVIFLEDGRTQPVGVVLKVDGSIAAVKFLKDSERACVAVNCLYSPLAAVF
GNNNNACSETSINSTTPNSPDPISWLNDCRLLRKEELVVVKQPLVSRVPD
IVQKHPKCIPTEVFLEAKPTTLSPCFGILGMAVENELIHLLVRKSTSSKC
IEYKLLSLGKKVISSHRLNTSANGFLGRAPQPCLIASPLESEYSELKNGM
IFNAERHRPIFLRDGNGTVYPLLFNESHSSNNMSSKFEPIPSPHWLDLPP
VRCVDFGFVNVNNYNIKSPIIPGSNSNSTNDTHKNSKSKFNRLLVGVLVL
ESQTLMHHILRTDDKKVSNVMDNFAVGSEYDGFVQRIISEKLDGQRNIIH
VAVNMCRPLSNVETEWKLSNILNYRSKKSSTNTNVEDLSQRSNWSLEHSM
NISSFPYRRWIDMGRPINDVNQFNYSRSNDRQASSVRFTVMSSSNTSRSS
ILTGDSNSGWLLPPIHLDEKEKRSNSYRIINIIINHPCMENHLIGLLSQR
NADGQTPFMQSVSQRIYPLALFLLDCIMDLCDMQYVSVLNSKSQLALSMI
FPPAISIAANKNSISSMYEDNPLQVLCQNDGCSFTWTGPDHIRQDIFECR
TCGLTESLCCCTECARVCHKGHDCHLKKTSPTAYCDCWEKCRCKALIVGD
NSARQELLKKLLQHTDLATLPNRRKEHLLLFLVKTVDRQFREHKQIRTSG
RRHATSVLNARHGNNVNFTASSHVSLLEPHHPAYEPPMPEYGLEPSNFAL
NALDAVLSNWPSVETLLLSGDRSDWVNNLVKNMDSSSRNDGINPLTDDEV
FLNYQSFSEQLDQFVFTLIAKTASSSVDILLNTLNKELQNEKSHPLTMKP
PTQTKVKTAAARLIRSVARVFVALQLQMAPDFNRKRQSNRLSNSVHVYSV
QPKPLDVCKRIFENLLFVSLSELPRIAADIIAPVRCGLLKPTANYAHFYQ
ISDAVRNLDQIFYSTNPDVDNRHEPVGNSDKNPKQNSQSNRINDSNLRNT
PNISRRTSINNRNNGASDSNSSNGNNLPEFHGNVRQNSLNGRQSRRRPYD
DDIDGSGAVISISESNVTETNGRNLDPVQLVRRRRQSTPISLSSRMNALI
DEEDEDDGHSSGDDNWNSNNDSRGISEDRQRSNQLNSIFFEESDGDGNTI
EGENDLDGDVDMEVYDEDHDTDIVPETESDSDDSISSSICVTEYNPEPVN
MTELTANRSIEQNTNSSLSVINMVDSGIRMKVDRPDAMETNIDNSETPSS
NNNAENNSVRISIRKSANIIENKGDPDSSANDTSMRMSMEDNIRFSVVAS
SDLTRSNPETTQSVLVELVTPLASVPNLIPQPTLNNATEWFRNQVDLDAI
SDDESDDDESSQITEDDDQDDMNESATDLSQPIAQQTQRNISSNSTIPDN
SANPDTQTNAQANTNSTTGNTTCGLQTTQVQLARAFCCLIKLLAGLLNQM
YYSREKNESVNQKEYDRFGLNLGQDNEYSSSCSPGATLSQSEEEHVMIES
SQQLGPIWIWICQSMDFLESQVCFANAFQRKHGTYKARPVPTFEQVNTPN
ISSAPSSGDANRADFLRYVVSMMRASSDEHGDQTPTSLNAVNYCHLAYLV
DALLYLMRICFGMVTDKVCCDGVDPSGPSIEDCVTAVNDHLKREPTLVQE
EVDDEQEDLNSLRPTIGSECGDSILDEDTNCPTLTCNYQSTNSSLLKPQI
NHRRDCQQKIDTSEDSFFCRTDYPQGWVGLGADSFQTPVSESLPLAYMPQ
LLQPPGPTDEVFGVLRRFEIDRNTINNQNFCGRSNEGQLPLHMGFSSRWA
DRLLDNNIIFSGVPVGNLRTRWRYSLELLSNSFEQNVGLEPGSVLVDFTH
FSLKETRFRKEMEKLRNQCRRDLSLIVNRERNLIICDTVTQLNTEYSRRN
STNTQNPLMCHRFKVKFNDEPGEGNGVARSFLTVFAEAVLSEELLIMNSS
LSNQKKQSSGISSRGSLYNRNEHNYIRMSAISRINTIAANTSSNISQTLN
SIPSSSWYSDALSIIGMNHNSSNNSSSRNFRPAMRIISNPQTVQSNSSNI
PSTRSIIRSDLSYTNTAHRLISAIAIFASSAPIVSNTSTSHVWGITSNSS
NLNNSIPQSTSINFSHYNIDNMPLVSTPHRLDFSDRGISRRSINMASSRP
PISSTASVLSTSSFSSVSLMGNNINLPSSHLHSLPSVTTRSVNSNTDMIY
SNSQIPMSIASESSISSNAQLGNIDPINLATGFTASLGNQAPIWVSSNWL
PMYSNSASMSNSLTSLTNLSRIQGFSPLHNQIPTSRHLEPSSIPTSSIAN
IQSNQNLNIYEMLRGKLPVNDPIYTMPASIRIPDIPTSSISSLPGTSGLS
SIQNISIFDILRSRIPGDDSLIQQMAYNLTAISGRSDLNGLLNQLSLKNI
NMNDVINNLMNSMDQVPRFSDLHQSESAIVYSNIEGSSETSQSTESNIEV
SIITFAIYLDSLLNTNNSSSNFSAAKSQPDDSSSLLPESHGPSTVLKTPS
IDPEQTPLFWQPGHPGFYCPRRVNLNDNNQEYTRNNIYRSVGRVIGISML
MNETMPLKLCRHVLKYILGLPIGWHDFAFFNSQLYESLRQLMKVAREAQL
MGIAGAPEDPLLEYNLNFTIVPREEEGGNGNSGDRKVIGMNSINLIPNGE
DVDVDSNNVFQYVKKYCITRMITIVKPQLDQIKNGVYDVLPKHALNGLSP
EDLRLLLNGTDEINVEVLISYTSFLDESSCTISNSQEKVTKFKKWFWQVV
MAFNSIQRQNLLYFWTSSPALPASNQGFQPMPTITIRPADDFHLPTANTC
ISRLYIPLYSTKIILREKLLQAIETKSFGFV*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR035983	Hect_E3_ubiquitin_ligase
IPR000569	HECT_dom
IPR003126	Znf_UBR
IPR024725	E3_UbLigase_EDD_UBA
IPR009091	RCC1/BLIP-II
IPR000048	IQ_motif_EF-hand-BS

Vocabulary: **molecular function**
Term	Definition
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding
GO:0043130	ubiquitin binding
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0016874	ligase activity

Vocabulary: **biological process**
Term	Definition
GO:0016567	protein ubiquitination

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR003126	Zinc finger, UBR-type	SMART	SM00396	push_1	coord: 1430..1497 e-value: 2.4E-23 score: 93.5
IPR003126	Zinc finger, UBR-type	PROSITE	PS51157	ZF_UBR	coord: 1430..1498 score: 8.533
IPR000569	HECT domain	SMART	SM00119	hect_3	coord: 3316..3681 e-value: 4.5E-72 score: 255.4
IPR000569	HECT domain	PFAM	PF00632	HECT	coord: 3367..3680 e-value: 5.0E-57 score: 193.7
IPR000569	HECT domain	PROSITE	PS50237	HECT	coord: 3386..3681 score: 54.708
None	No IPR available	GENE3D	G3DSA:1.10.8.10		coord: 193..245 e-value: 2.6E-30 score: 105.6
None	No IPR available	GENE3D	G3DSA:3.90.1750.10		coord: 2687..2830 e-value: 2.8E-5 score: 25.4
None	No IPR available	GENE3D	G3DSA:3.90.1750.10		coord: 3375..3559 e-value: 2.1E-23 score: 85.0
None	No IPR available	GENE3D	G3DSA:3.30.2160.10		coord: 3420..3524 e-value: 2.1E-23 score: 85.0
None	No IPR available	GENE3D	G3DSA:3.30.2410.10		coord: 3561..3681 e-value: 3.7E-39 score: 135.4
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 734..842
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 570..597
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1953..1983
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1963..1983
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 2091..2109
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 116..139
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1830..1893
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 2200..2253
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 2090..2109
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 570..584
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 761..808
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 2200..2224
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 3323..3345
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 2225..2253
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1825..1905
None	No IPR available	PANTHER	PTHR46276	FAMILY NOT NAMED	coord: 21..767 coord: 2670..2824 coord: 788..2650 coord: 3339..3681
IPR024725	E3 ubiquitin ligase EDD, ubiquitin-associated domain	PFAM	PF11547	E3_UbLigase_EDD	coord: 195..244 e-value: 6.4E-32 score: 109.0
IPR024725	E3 ubiquitin ligase EDD, ubiquitin-associated domain	CDD	cd14423	CUE_UBR5	coord: 199..245 e-value: 7.9233E-24 score: 94.4566
IPR035983	HECT, E3 ligase catalytic domain	SUPERFAMILY	SSF56204	Hect, E3 ligase catalytic domain	coord: 3376..3674
IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	SUPERFAMILY	SSF50985	RCC1/BLIP-II	coord: 388..558