Piezo-type mechanosensitive ion channel component
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30008757 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 429.869 bits (1104), Expect = 1.461e-124 Identity = 226/591 (38.24%), Postives = 371/591 (62.77%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI---NTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMM----WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+++F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ + QL YFVKC+YF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S++++ ++ + +++F + + + +L+++E +D T ++ S+++W I+PP +K+ +L P +S + +R + +E I S L N + N+ +I +T+ + T V + I+P ++ A + S+ ++NN +++I++ + DN WW +N + + Y PN + L + +FN+++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2171 IKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSE-IATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLN-LTGNRIYNPNSQA-------LELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2749 HSP 2 Score: 125.946 bits (315), Expect = 3.213e-28 Identity = 76/165 (46.06%), Postives = 102/165 (61.82%), Query Frame = 3
Query: 1275 LLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVD-PLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW--RDHTEFAQDLEIVDKE-------QDGRNKIKS 1739
LL ++ N + SE VCYF++ILNHM+S ++ +L P+++FLWAMLSVPRPS+ FW+ I YTE+ IV+KY FQF F +N+ D P P IIG+EK + Y + DLIQLL +F HR LK +GLW D TE E D E +D + +KS
Sbjct: 1909 LLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKS 2073
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 429.869 bits (1104), Expect = 1.870e-124 Identity = 226/591 (38.24%), Postives = 371/591 (62.77%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI---NTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMM----WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+++F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ + QL YFVKC+YF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S++++ ++ + +++F + + + +L+++E +D T ++ S+++W I+PP +K+ +L P +S + +R + +E I S L N + N+ +I +T+ + T V + I+P ++ A + S+ ++NN +++I++ + DN WW +N + + Y PN + L + +FN+++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2196 IKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSE-IATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLN-LTGNRIYNPNSQA-------LELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2774 HSP 2 Score: 125.946 bits (315), Expect = 3.686e-28 Identity = 76/165 (46.06%), Postives = 102/165 (61.82%), Query Frame = 3
Query: 1275 LLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVD-PLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW--RDHTEFAQDLEIVDKE-------QDGRNKIKS 1739
LL ++ N + SE VCYF++ILNHM+S ++ +L P+++FLWAMLSVPRPS+ FW+ I YTE+ IV+KY FQF F +N+ D P P IIG+EK + Y + DLIQLL +F HR LK +GLW D TE E D E +D + +KS
Sbjct: 1934 LLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKS 2098
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 429.483 bits (1103), Expect = 2.347e-124 Identity = 226/591 (38.24%), Postives = 371/591 (62.77%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI---NTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMM----WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+++F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ + QL YFVKC+YF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S++++ ++ + +++F + + + +L+++E +D T ++ S+++W I+PP +K+ +L P +S + +R + +E I S L N + N+ +I +T+ + T V + I+P ++ A + S+ ++NN +++I++ + DN WW +N + + Y PN + L + +FN+++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2122 IKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSE-IATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLN-LTGNRIYNPNSQA-------LELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2700 HSP 2 Score: 125.946 bits (315), Expect = 3.692e-28 Identity = 76/165 (46.06%), Postives = 102/165 (61.82%), Query Frame = 3
Query: 1275 LLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVD-PLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW--RDHTEFAQDLEIVDKE-------QDGRNKIKS 1739
LL ++ N + SE VCYF++ILNHM+S ++ +L P+++FLWAMLSVPRPS+ FW+ I YTE+ IV+KY FQF F +N+ D P P IIG+EK + Y + DLIQLL +F HR LK +GLW D TE E D E +D + +KS
Sbjct: 1860 LLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKS 2024
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO1 (piezo type mechanosensitive ion channel component 1 [Source:HGNC Symbol;Acc:HGNC:28993]) HSP 1 Score: 387.497 bits (994), Expect = 1.851e-110 Identity = 225/596 (37.75%), Postives = 357/596 (59.90%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKI----NMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ---NQNNTYLNISLSMKTDNA------MMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
+RRF+ + + K+ DVY MFL + + F+IIIFG+ +FG + + D + +++P F+ M++ QF +++DRAL+LRK V GK FQ+ VL IH W+FF LP +T++ FN + QL YFVKCIYFALSAYQ++ GYP RILGNFLT+ +N++NLFLF+G+ +VPFL ELR VMDW+WTD++++ WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI++F IW PL+ S + + V PI+ + ++ +G Y PLF S+++ ++ P T + +EE+ + ++ + P+D I+ +S +W I+PP ++K +L A + + N Q + T + EK + + A+LL + + +V +P +FP+++ A EAN + Q N+ YL + + ++ + + WW V E+ + ++ C L + IF++++S G + + YGI+G+Y + V+ +F+R F+S IS+ I EELP VDRI KL +I+LVRE ++L LEE+L AKLIFLYRS ETMIKWT+
Sbjct: 1942 LRRFFHDILHTKYRAATDVYALMFLADVVDFIIIIFGFWAFGKHSAATDITSS-LSDDQVPEAFLVMLLIQFSTMVVDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSSWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQ----SVVIPNLFPKYIRAPNG--PEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWW-VIELQECRTDCN----------LLPMVIFSDKVSPPSLGFL-AGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTR 2518 HSP 2 Score: 115.161 bits (287), Expect = 6.560e-25 Identity = 62/126 (49.21%), Postives = 85/126 (67.46%), Query Frame = 3
Query: 1311 YSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRV---DPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTE 1679
+SE +CYF++ILNHM++ + SL P++VFLWAMLS+PRPSK FW+ I +TEI +V+KY+FQF F +N R P + P I+G+EK+ Y DL+QL+ +F HR L GLW DH E
Sbjct: 1686 HSELLCYFIIILNHMVTASAGSLVLPVLVFLWAMLSIPRPSKRFWMTAIVFTEIAVVVKYLFQFGFFPWNSHVVLRRYENKPYFPPRILGLEKTDGYIKYDLVQLMALFFHRSQLLCYGLW-DHEE 1810
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 250.751 bits (639), Expect = 1.383e-66 Identity = 107/216 (49.54%), Postives = 161/216 (74.54%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGE 2444
+++F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ + QL YFVKC+YF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E
Sbjct: 2171 IKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESE 2385 HSP 2 Score: 152.14 bits (383), Expect = 3.762e-36 Identity = 99/311 (31.83%), Postives = 175/311 (56.27%), Query Frame = 3
Query: 2634 PLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI---NTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMM----WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
P+F S++++ ++ + +++F + + + +L+++E +D T ++ S+++W I+PP +K+ +L P +S + +R + +E I S L N + N+ +I +T+ + T V + I+P ++ A + S+ ++NN +++I++ + DN WW +N + + Y PN + L + +FN+++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2387 PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSE-IATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLN-LTGNRIYNPNSQA-------LELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2686 HSP 3 Score: 125.946 bits (315), Expect = 3.221e-28 Identity = 76/165 (46.06%), Postives = 102/165 (61.82%), Query Frame = 3
Query: 1275 LLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVD-PLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW--RDHTEFAQDLEIVDKE-------QDGRNKIKS 1739
LL ++ N + SE VCYF++ILNHM+S ++ +L P+++FLWAMLSVPRPS+ FW+ I YTE+ IV+KY FQF F +N+ D P P IIG+EK + Y + DLIQLL +F HR LK +GLW D TE E D E +D + +KS
Sbjct: 1909 LLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKS 2073
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 348.591 bits (893), Expect = 1.938e-101 Identity = 258/953 (27.07%), Postives = 445/953 (46.69%), Query Frame = 3
Query: 969 SKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXX--XXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHT-----------------------EFAQDLEIVDKEQD------GRNKIKSSYEESSPTSNKWSCNPIYKMR------RFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENN-----MRPLTKKTFEEMKECHKFHLPSKD------------YLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAY-----KRTLSEANSLHQ---NQNNTYLNISLSMKTDNAMMWWE--VNEIIQGQS-----YCPNPDSPSKKYL---------------FLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFL-RTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLE 3563
SK +++ + I + D V +N +E+R + L EK+ +K +SN ++ + V S V S N E ++ + +S L ++ N +++ +CYF I+ +++G L +LP PLM W LS PRPSK FW+ +ITYTE VIVIK++ QF F+ +N T ++DP+ + + G+ + ++A+ D++ L +F HR L+ GLW+D + AQ+ ++V + D G + S + + C P + RF ++ +PKF D+Y MF + I FLI+ FGY +FG G + N D +K ++IPV + M++ + IIIDRAL+LRK V GK I+Q+ + +H W+F LP++T++ S Q LY +K YF +SA+Q+++GYP +GN LT + N+ FK +M +PFL+ELR +DW WTD+S+ + + +E+ ++ IF +KC R E +P RG + +VKY +G I+I I+ PL++ S + P + + I++ Y PL+ ++ +N + + + + ++D YL+ + +D + S+ W I+ + +KLS + +N + E + ++ ++S + + I + + P + P+ + A+ + L+ S+ N N +N + K+D A W++ + QG+S + + P + +L + F +R + +F G++ +Y + VV R L R ++ + ELPN D + K+ +IYLVRE K LE+ L AKLIFL+RS T+I+WT+ K E
Sbjct: 97 SKVESTAKFIQKMIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKLTDIRSAV----DLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLS---RNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGH-PILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSKKKQE 1038
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 345.125 bits (884), Expect = 1.925e-97 Identity = 258/953 (27.07%), Postives = 445/953 (46.69%), Query Frame = 3
Query: 969 SKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXX--XXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHT-----------------------EFAQDLEIVDKEQD------GRNKIKSSYEESSPTSNKWSCNPIYKMR------RFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENN-----MRPLTKKTFEEMKECHKFHLPSKD------------YLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAY-----KRTLSEANSLHQ---NQNNTYLNISLSMKTDNAMMWWE--VNEIIQGQS-----YCPNPDSPSKKYL---------------FLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFL-RTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLE 3563
SK +++ + I + D V +N +E+R + L EK+ +K +SN ++ + V S V S N E ++ + +S L ++ N +++ +CYF I+ +++G L +LP PLM W LS PRPSK FW+ +ITYTE VIVIK++ QF F+ +N T ++DP+ + + G+ + ++A+ D++ L +F HR L+ GLW+D + AQ+ ++V + D G + S + + C P + RF ++ +PKF D+Y MF + I FLI+ FGY +FG G + N D +K ++IPV + M++ + IIIDRAL+LRK V GK I+Q+ + +H W+F LP++T++ S Q LY +K YF +SA+Q+++GYP +GN LT + N+ FK +M +PFL+ELR +DW WTD+S+ + + +E+ ++ IF +KC R E +P RG + +VKY +G I+I I+ PL++ S + P + + I++ Y PL+ ++ +N + + + + ++D YL+ + +D + S+ W I+ + +KLS + +N + E + ++ ++S + + I + + P + P+ + A+ + L+ S+ N N +N + K+D A W++ + QG+S + + P + +L + F +R + +F G++ +Y + VV R L R ++ + ELPN D + K+ +IYLVRE K LE+ L AKLIFL+RS T+I+WT+ K E
Sbjct: 789 SKVESTAKFIQKMIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKLTDIRSAV----DLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLS---RNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGH-PILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSKKKQE 1730
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 345.125 bits (884), Expect = 1.925e-97 Identity = 258/953 (27.07%), Postives = 445/953 (46.69%), Query Frame = 3
Query: 969 SKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXX--XXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHT-----------------------EFAQDLEIVDKEQD------GRNKIKSSYEESSPTSNKWSCNPIYKMR------RFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENN-----MRPLTKKTFEEMKECHKFHLPSKD------------YLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAY-----KRTLSEANSLHQ---NQNNTYLNISLSMKTDNAMMWWE--VNEIIQGQS-----YCPNPDSPSKKYL---------------FLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFL-RTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLE 3563
SK +++ + I + D V +N +E+R + L EK+ +K +SN ++ + V S V S N E ++ + +S L ++ N +++ +CYF I+ +++G L +LP PLM W LS PRPSK FW+ +ITYTE VIVIK++ QF F+ +N T ++DP+ + + G+ + ++A+ D++ L +F HR L+ GLW+D + AQ+ ++V + D G + S + + C P + RF ++ +PKF D+Y MF + I FLI+ FGY +FG G + N D +K ++IPV + M++ + IIIDRAL+LRK V GK I+Q+ + +H W+F LP++T++ S Q LY +K YF +SA+Q+++GYP +GN LT + N+ FK +M +PFL+ELR +DW WTD+S+ + + +E+ ++ IF +KC R E +P RG + +VKY +G I+I I+ PL++ S + P + + I++ Y PL+ ++ +N + + + + ++D YL+ + +D + S+ W I+ + +KLS + +N + E + ++ ++S + + I + + P + P+ + A+ + L+ S+ N N +N + K+D A W++ + QG+S + + P + +L + F +R + +F G++ +Y + VV R L R ++ + ELPN D + K+ +IYLVRE K LE+ L AKLIFL+RS T+I+WT+ K E
Sbjct: 789 SKVESTAKFIQKMIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKLTDIRSAV----DLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLS---RNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGH-PILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSKKKQE 1730
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 345.125 bits (884), Expect = 2.052e-97 Identity = 258/953 (27.07%), Postives = 445/953 (46.69%), Query Frame = 3
Query: 969 SKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXX--XXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHT-----------------------EFAQDLEIVDKEQD------GRNKIKSSYEESSPTSNKWSCNPIYKMR------RFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENN-----MRPLTKKTFEEMKECHKFHLPSKD------------YLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAY-----KRTLSEANSLHQ---NQNNTYLNISLSMKTDNAMMWWE--VNEIIQGQS-----YCPNPDSPSKKYL---------------FLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFL-RTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLE 3563
SK +++ + I + D V +N +E+R + L EK+ +K +SN ++ + V S V S N E ++ + +S L ++ N +++ +CYF I+ +++G L +LP PLM W LS PRPSK FW+ +ITYTE VIVIK++ QF F+ +N T ++DP+ + + G+ + ++A+ D++ L +F HR L+ GLW+D + AQ+ ++V + D G + S + + C P + RF ++ +PKF D+Y MF + I FLI+ FGY +FG G + N D +K ++IPV + M++ + IIIDRAL+LRK V GK I+Q+ + +H W+F LP++T++ S Q LY +K YF +SA+Q+++GYP +GN LT + N+ FK +M +PFL+ELR +DW WTD+S+ + + +E+ ++ IF +KC R E +P RG + +VKY +G I+I I+ PL++ S + P + + I++ Y PL+ ++ +N + + + + ++D YL+ + +D + S+ W I+ + +KLS + +N + E + ++ ++S + + I + + P + P+ + A+ + L+ S+ N N +N + K+D A W++ + QG+S + + P + +L + F +R + +F G++ +Y + VV R L R ++ + ELPN D + K+ +IYLVRE K LE+ L AKLIFL+RS T+I+WT+ K E
Sbjct: 745 SKVESTAKFIQKMIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKLTDIRSAV----DLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLS---RNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGH-PILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSKKKQE 1686
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 344.739 bits (883), Expect = 2.507e-97 Identity = 258/953 (27.07%), Postives = 445/953 (46.69%), Query Frame = 3
Query: 969 SKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXX--XXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHT-----------------------EFAQDLEIVDKEQD------GRNKIKSSYEESSPTSNKWSCNPIYK------MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENN-----MRPLTKKTFEEMKECHKFHLPSKD------------YLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAY-----KRTLSEANSLHQ---NQNNTYLNISLSMKTDNAMMWWE--VNEIIQGQS-----YCPNPDSPSKKYL---------------FLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFL-RTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLE 3563
SK +++ + I + D V +N +E+R + L EK+ +K +SN ++ + V S V S N E ++ + +S L ++ N +++ +CYF I+ +++G L +LP PLM W LS PRPSK FW+ +ITYTE VIVIK++ QF F+ +N T ++DP+ + + G+ + ++A+ D++ L +F HR L+ GLW+D + AQ+ ++V + D G + S + + C P + RF ++ +PKF D+Y MF + I FLI+ FGY +FG G + N D +K ++IPV + M++ + IIIDRAL+LRK V GK I+Q+ + +H W+F LP++T++ S Q LY +K YF +SA+Q+++GYP +GN LT + N+ FK +M +PFL+ELR +DW WTD+S+ + + +E+ ++ IF +KC R E +P RG + +VKY +G I+I I+ PL++ S + P + + I++ Y PL+ ++ +N + + + + ++D YL+ + +D + S+ W I+ + +KLS + +N + E + ++ ++S + + I + + P + P+ + A+ + L+ S+ N N +N + K+D A W++ + QG+S + + P + +L + F +R + +F G++ +Y + VV R L R ++ + ELPN D + K+ +IYLVRE K LE+ L AKLIFL+RS T+I+WT+ K E
Sbjct: 763 SKVESTAKFIQKMIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKLTDIRSAV----DLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLS---RNTSVNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGDPGH-PILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPRINTTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSKKKQE 1704
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335175) HSP 1 Score: 426.402 bits (1095), Expect = 1.098e-123 Identity = 261/809 (32.26%), Postives = 433/809 (53.52%), Query Frame = 3
Query: 1314 SEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFI--SFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRD-----HTEFAQDLEIVDKEQDGRN---------------KIKSSYEESS-PTSNKWSCNPIYKMRR----------FYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPG-TDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCER--PSTDSK---STEKIVRFTQSRFLTNPEKANLLHLI-----------NTKFNSTN------VYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAM--MWWEVNEIIQGQSYCPNP--DSPSKKYLF------LTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
++ +CY ++ +N +++ +L SLP P+MVFLW LS+PRP+K FW+ LI YT+ +++IK IFQF I ++++ N PL I G+E +YAI DLI LL +FLHR LK+ GLW+ +F + +D+ D N K+ ++S P S ++S I ++ R F+S + + DVY MFLC+F+ F +++FG+ +FG T+S + ++ NK+P+PF+ M++ QF+ I+IDRAL+LRK + K IF F V+ IH W+FF +P +T++ FNS P + Y +KC Y LS+YQ+KSGYP RILGNF T+ F+ +N+ FK YM +PFLYELR ++DW+ DS++ + W+++EDIFS I++++C R ET +P R + + + K +G I++ CIWGPL + + P S SI +G Y P++ ++ +++ + + + +M + + ++ ++ D + + S ++W I PP ++L L +LK R P+ K E + +S +A L+H++ N N T V +P + P+F+ + S+ ++ Y + + M DN +WWE+ + YC + + K+ + + ++ FN++ + F + ++ GI+G+Y + + RF+++F + I E+LP VDR+ +L +IYLVRE + LEE L AKL+FLYRS ET+IKWT+
Sbjct: 1886 TDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKSRL--ATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYT-TNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLR-NNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESF----EGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRD------YCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFL-TAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2676
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0347414) HSP 1 Score: 426.402 bits (1095), Expect = 1.118e-123 Identity = 260/809 (32.14%), Postives = 434/809 (53.65%), Query Frame = 3
Query: 1314 SEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFI--SFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWR-----------------DHTEFAQDLEIVDKEQ---DGRNKIKSSYEESS-PTSNKWSCNPIYKMRR----------FYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPG-TDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLS-----IPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI-----------NTKFNSTN------VYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAM--MWWEVNEIIQGQSYCPNP--DSPSKKYLF------LTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
++ +CY ++ +N +++ +L SLP P+MVFLW LS+PRP+K FW+ LI YT+ +++IK IFQF I ++++ N PL I G+E +YAI DLI LL +FLHR LK+ GLW+ D + + +L D Q D K+ ++S P S ++S I ++ R F+S + + DVY MFLC+F+ F +++FG+ +FG T+S + ++ NK+P+PF+ M++ QF+ I+IDRAL+LRK + K IF F V+ IH W+FF +P +T++ FNS P + Y +KC Y LS+YQ+KSGYP RILGNF T+ F+ +N+ FK YM +PFLYELR ++DW+ DS++ + W+++EDIFS I++++C R ET +P R + + + K +G I++ CIWGPL + + P S SI +G Y P++ ++ +++ + + + +M + + ++ ++ D + + S ++W I PP ++L L R S + +A + ++ E + +S +A L+H++ N N T V +P + P+F+ + S+ ++ Y + + M DN +WWE+ + YC + + K+ + + ++ FN++ + F + ++ GI+G+Y + + RF+++F + I E+LP VDR+ +L +IYLVRE + LEE L AKL+FLYRS ET+IKWT+
Sbjct: 2015 TDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKSRL--ATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYT-TNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAPA-KGLKENVGDEHAISLDESF----EGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRD------YCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFL-TAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2805
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335183) HSP 1 Score: 426.402 bits (1095), Expect = 1.118e-123 Identity = 278/909 (30.58%), Postives = 472/909 (51.93%), Query Frame = 3
Query: 1026 NLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNS--KNQEEYLKEQEXXXXXXXXXLLAISLGN--VAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFI--SFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRD-----HTEFAQDLEIVDKEQDGRN---------------KIKSSYEESS-PTSNKWSCNPIYKMRR----------FYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPG-TDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCER--PSTDSK---STEKIVRFTQSRFLTNPEKANLLHLI-----------NTKFNSTN------VYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAM--MWWEVNEIIQGQSYCPNP--DSPSKKYLF------LTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
L + +N +++ YR + R L EK+ +K + R+ L + F+ S ++ E+ E+E R ++ + + + + ++ +CY ++ +N +++ +L SLP P+MVFLW LS+PRP+K FW+ LI YT+ +++IK IFQF I ++++ N PL I G+E +YAI DLI LL +FLHR LK+ GLW+ +F + +D+ D N K+ ++S P S ++S I ++ R F+S + + DVY MFLC+F+ F +++FG+ +FG T+S + ++ NK+P+PF+ M++ QF+ I+IDRAL+LRK + K IF F V+ IH W+FF +P +T++ FNS P + Y +KC Y LS+YQ+KSGYP RILGNF T+ F+ +N+ FK YM +PFLYELR ++DW+ DS++ + W+++EDIFS I++++C R ET +P R + + + K +G I++ CIWGPL + + P S SI +G Y P++ ++ +++ + + + +M + + ++ ++ D + + S ++W I PP ++L L +LK R P+ K E + +S +A L+H++ N N T V +P + P+F+ + S+ ++ Y + + M DN +WWE+ + YC + + K+ + + ++ FN++ + F + ++ GI+G+Y + + RF+++F + I E+LP VDR+ +L +IYLVRE + LEE L AKL+FLYRS ET+IKWT+
Sbjct: 1623 TLTIRLNRFSRNYRFVNRILAGEKKTLK-------ESSSLNRLGLSS------AAAMFHFLKSNLESAGEFNLEEENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKSRL--ATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYT-TNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLR-NNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESF----EGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRD------YCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFL-TAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2500
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335181) HSP 1 Score: 426.402 bits (1095), Expect = 1.190e-123 Identity = 278/916 (30.35%), Postives = 475/916 (51.86%), Query Frame = 3
Query: 1026 NLIVLINTWTKEYRRIRRTLDNEKRLVK---------LKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXXXXXXXXXLLAISLGN--VAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFI--SFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRD-----HTEFAQDLEIVDKEQDGRN---------------KIKSSYEESS-PTSNKWSCNPIYKMRR----------FYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPG-TDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCER--PSTDSK---STEKIVRFTQSRFLTNPEKANLLHLI-----------NTKFNSTN------VYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAM--MWWEVNEIIQGQSYCPNP--DSPSKKYLF------LTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
L + +N +++ YR + R L EK+ +K L + + + + +E + + +S +K E+ E+E R ++ + + + + ++ +CY ++ +N +++ +L SLP P+MVFLW LS+PRP+K FW+ LI YT+ +++IK IFQF I ++++ N PL I G+E +YAI DLI LL +FLHR LK+ GLW+ +F + +D+ D N K+ ++S P S ++S I ++ R F+S + + DVY MFLC+F+ F +++FG+ +FG T+S + ++ NK+P+PF+ M++ QF+ I+IDRAL+LRK + K IF F V+ IH W+FF +P +T++ FNS P + Y +KC Y LS+YQ+KSGYP RILGNF T+ F+ +N+ FK YM +PFLYELR ++DW+ DS++ + W+++EDIFS I++++C R ET +P R + + + K +G I++ CIWGPL + + P S SI +G Y P++ ++ +++ + + + +M + + ++ ++ D + + S ++W I PP ++L L +LK R P+ K E + +S +A L+H++ N N T V +P + P+F+ + S+ ++ Y + + M DN +WWE+ + YC + + K+ + + ++ FN++ + F + ++ GI+G+Y + + RF+++F + I E+LP VDR+ +L +IYLVRE + LEE L AKL+FLYRS ET+IKWT+
Sbjct: 1649 TLTIRLNRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLERKQSI--------NSSPPAKGAGEFNLEEENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKSRL--ATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYT-TNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLR-NNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESF----EGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRD------YCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFL-TAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2538
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335182) HSP 1 Score: 426.017 bits (1094), Expect = 1.487e-123 Identity = 261/809 (32.26%), Postives = 433/809 (53.52%), Query Frame = 3
Query: 1314 SEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFI--SFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRD-----HTEFAQDLEIVDKEQDGRN---------------KIKSSYEESS-PTSNKWSCNPIYKMRR----------FYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPG-TDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCER--PSTDSK---STEKIVRFTQSRFLTNPEKANLLHLI-----------NTKFNSTN------VYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAM--MWWEVNEIIQGQSYCPNP--DSPSKKYLF------LTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
++ +CY ++ +N +++ +L SLP P+MVFLW LS+PRP+K FW+ LI YT+ +++IK IFQF I ++++ N PL I G+E +YAI DLI LL +FLHR LK+ GLW+ +F + +D+ D N K+ ++S P S ++S I ++ R F+S + + DVY MFLC+F+ F +++FG+ +FG T+S + ++ NK+P+PF+ M++ QF+ I+IDRAL+LRK + K IF F V+ IH W+FF +P +T++ FNS P + Y +KC Y LS+YQ+KSGYP RILGNF T+ F+ +N+ FK YM +PFLYELR ++DW+ DS++ + W+++EDIFS I++++C R ET +P R + + + K +G I++ CIWGPL + + P S SI +G Y P++ ++ +++ + + + +M + + ++ ++ D + + S ++W I PP ++L L +LK R P+ K E + +S +A L+H++ N N T V +P + P+F+ + S+ ++ Y + + M DN +WWE+ + YC + + K+ + + ++ FN++ + F + ++ GI+G+Y + + RF+++F + I E+LP VDR+ +L +IYLVRE + LEE L AKL+FLYRS ET+IKWT+
Sbjct: 1728 TDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKSRL--ATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYT-TNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLR-NNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESF----EGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRD------YCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFL-TAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2518
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-131119-76]) HSP 1 Score: 426.787 bits (1096), Expect = 1.755e-131 Identity = 225/593 (37.94%), Postives = 365/593 (61.55%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPE---KANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ-NQNNTYLNISLSMK-----TDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+R+F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P F+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T+++F+ QL YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IFVLKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S + + V P++ S +I +G + P+F S+++N ++ LT+ F+ + + + +L+++ +D T ++ +S+++W I+PP K L + LS + M +R + +E F + +T + + L+ L+N N T V + +FP F+ A + S A + Q ++ Y +I L ++ +++ WW V+E+ Q ++ L +++F++++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELP VDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 272 IRQFFYSLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYLNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKELTESDFKNFINSYNYVPSAMQFLEAYRAEDVTVAELEGSSNSLWTISPPSRKNLMDVLS-KEDQFPVTMTWSIQRNLSLGAKSE----FAMDKHVTYLDIKTRQELIALLNGTRN-TPVLIEQVFPCFIRA--PSDSNAKPIEQLYEDGVYKSIQLDLERSANSSEDLQEWWIVDELRSAQK--------QQREAGLQLYVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 846 HSP 2 Score: 118.627 bits (296), Expect = 1.930e-26 Identity = 73/168 (43.45%), Postives = 102/168 (60.71%), Query Frame = 3
Query: 1278 LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTN-DRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWS 1778
L SL NV + +S+ VCY ++ILNHM+S ++ +L P+++FLWAMLSVPRPSK FW+ I YTE+ IVIKY FQF F FN++ D+ P P IIG+EK + Y DL+QLL +F HR LK GLW + + + G + + E SP + ++
Sbjct: 23 LCYSLYNVLVSHSQMVCYLVIILNHMISASVATLVLPVLIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQSIEVDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCYGLWDEE----EPRSVSPHTHSGAEEKAECFSEKSPVEDTYT 186
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: LO018508.1 (pep chromosome:GRCz11:2:54327160:54353625:1 gene:ENSDARG00000112723.1 transcript:ENSDART00000182320.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:LO018508.1) HSP 1 Score: 416.387 bits (1069), Expect = 7.222e-131 Identity = 228/590 (38.64%), Postives = 352/590 (59.66%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTN-VYLPTIFPRFLTAYKRTLSEANSLHQNQ-NNTYLNISLSMKTDNA----MMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+R+F+ + +P+++ DVYV MFL + + F+II+FG+ +FG AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP IT+++F+ QL YFVKCIYF LSAYQ++ GYP RILGNFLT+ +NY NLFLF+G+ ++PFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S + + V P+E S S+ +G P+F S+++N+++ +T +L+S+ P+D T ++ +S+++W I+PP + LK L+ R + +R + E ++ + L + NS+ V + IFPR++ R S++N+ +Q N Y++I+L + N+ WW VN+ G P P L I+I ++++S G + + YGI+G+Y + V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 26 IRQFFYNLVHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHQGGADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVVGKVIFQVILVFGIHFWMFFILPGITERRFSQNTIAQLWYFVKCIYFGLSAYQIRCGYPTRILGNFLTKSYNYANLFLFQGFRLIPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLEVSVSLTLGGLQPIFTMSAQQNHIKSVTGNAIM--------------FLESYFPEDLTIAHLEGSSNSLWTISPPSKENLKNMLNDTREPFPLTFTWSIQRNLSLGAKAET----AMGKYFIELDDETRKGLTDQLGNSSQRVTIKKIFPRYI----RAPSDSNAKPIDQLYNEYMDITLFLNKKNSSEGVQEWWIVNQTDSG----PLPGLNGSG---LQIYIISDQVSPPSLGFL-AGYGIMGLYMSVVLVIGKFVREFFSGISHTIMFEELPNVDRILKLCTDIFLVRETGELDLEEDLYAKLIFLYRSPETMIKWTRE 584
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-131119-76]) HSP 1 Score: 426.017 bits (1094), Expect = 2.204e-123 Identity = 224/589 (38.03%), Postives = 363/589 (61.63%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ-NQNNTYLNISLSMK-----TDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
+R+F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P F+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T+++F+ QL YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IFVLKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S + + V P++ S +I +G + P+F S+++N ++ LT+ F+ + + + +L+++ +D T ++ +S+++W I+PP K L + LS + M +R + +E + +L + L+ L+N N T V + +FP F+ A + S A + Q ++ Y +I L ++ +++ WW V+E+ Q ++ L +++F++++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELP VDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2045 IRQFFYSLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYLNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKELTESDFKNFINSYNYVPSAMQFLEAYRAEDVTVAELEGSSNSLWTISPPSRKNLMDVLS-KEDQFPVTMTWSIQRNLSLGAKSEFAMD-KHVTYLDIKTRQELIALLNGTRN-TPVLIEQVFPCFIRA--PSDSNAKPIEQLYEDGVYKSIQLDLERSANSSEDLQEWWIVDELRSAQK--------QQREAGLQLYVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTR 2618 HSP 2 Score: 118.627 bits (296), Expect = 4.063e-26 Identity = 73/168 (43.45%), Postives = 102/168 (60.71%), Query Frame = 3
Query: 1278 LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTN-DRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWS 1778
L SL NV + +S+ VCY ++ILNHM+S ++ +L P+++FLWAMLSVPRPSK FW+ I YTE+ IVIKY FQF F FN++ D+ P P IIG+EK + Y DL+QLL +F HR LK GLW + + + G + + E SP + ++
Sbjct: 1796 LCYSLYNVLVSHSQMVCYLVIILNHMISASVATLVLPVLIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQSIEVDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCYGLWDEE----EPRSVSPHTHSGAEEKAECFSEKSPVEDTYT 1959
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:ZFIN;Acc:ZDB-GENE-041111-255]) HSP 1 Score: 384.03 bits (985), Expect = 1.302e-109 Identity = 217/590 (36.78%), Postives = 351/590 (59.49%), Query Frame = 3
Query: 1806 FYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIV-RFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ---NQNNTYLNISLSM------KTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
F+ + + ++ DVY MFL + + F+IIIFG+ +FG + +AD A + +++P F+ M++ QF +IIDRAL+LRK + GK IFQ+ V IH W+FF LP +T++ FN QL YF KCIYF LSAYQ++ GYP RILGNFLT+ FN++NLFLF+G+ +VPFL ELR VMDW+WTD++++ +WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI++F IW PL+ S + + V P++ + ++ +G Y PLF S ++ +++P T+ + ++ + + ++ + +D I+ +S +VW I+PP ++L ++L + + + +R + E + + S NP +A+L L+ V++P +FP ++ A + +EA + Q + ++++S+ T A WW+++ I + C L + IFN+++S G + + YGI+G+Y + V+ +F+R F+S IS+ I EELP DRI KL +I+LVRE +L LEE+L +KLIFLYRS ETMIKWT+
Sbjct: 1858 FFQNILHAEYRASTDVYALMFLTDVVDFIIIIFGFWAFGKHSAAADIASS-LSEDQVPEAFLVMLLIQFSTMIIDRALYLRKSILGKLIFQVILVFGIHLWMFFILPAVTERMFNHNSVAQLWYFFKCIYFTLSAYQIRCGYPTRILGNFLTKKFNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKRIVKYGMGGLIILFLICIIWFPLLFISLVKSVVGVVNHPVDVTVTVKLGGYEPLFTMSVQQQSIQPFTESRYNQLNNQFSKNAVAMQFITMYSYEDIVTANIEGSSGSVWRISPPSRQELIKELLSSTGDMTLRLDWNFQRDLGKGGTVENTFDKHSISLAPKNPVRADLASLL-LGTRKDPVHVPHMFPNYIRA--PSGAEAKPVMQLFDGDEEGFQDVTVSLMREASVNTTGAQEWWDIS-IADCKESCN----------VLPMIIFNDKVSPPSLGFL-AGYGIMGLYVSVVLVIGKFVRGFFSEISHSIMFEELPCADRILKLCMDIFLVRETGELELEEELYSKLIFLYRSPETMIKWTR 2431 HSP 2 Score: 121.709 bits (304), Expect = 3.970e-27 Identity = 69/150 (46.00%), Postives = 103/150 (68.67%), Query Frame = 3
Query: 1224 EEYLKEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFN---ETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW 1664
+E ++ +EF S++R L +L NV +SE VCYF+++LN++++ ++ SL P++VFLWAMLSVPRPSK FW+ I YTE+++V+KY+FQF F +N E + P + P I+G+EK+ NY DL+QLL +F HR L+ GLW
Sbjct: 1596 DELIQSREFYSSQNRLLKLLFALYNVLAAHSELVCYFIIVLNNLVTASVISLVLPVLVFLWAMLSVPRPSKRFWMTAIIYTEVMVVVKYLFQFGFFPWNTEYELKLNEDKPFFPPRILGLEKTDNYIRYDLLQLLVLFFHRSLLQRYGLW 1745
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: si:dkey-11f4.7 (si:dkey-11f4.7 [Source:ZFIN;Acc:ZDB-GENE-070912-361]) HSP 1 Score: 264.618 bits (675), Expect = 1.733e-79 Identity = 126/280 (45.00%), Postives = 192/280 (68.57%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYS 2633
+R+F+ + +P+++ DVY MFL + + F+IIIFGY +FG + +AD + + +++P F+ M++ QF +I+DRAL+LRK + GK +FQ+ V IH W+FF LP +T+++FN QL YFVKCIYF LSAYQ+K GYP R+LGNFLT++ NY NLFLF+G+ +VPFL ELR VMDW+WTD++++ +W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY++G I+ +W PL+ S + + V P++ S +++ Y
Sbjct: 9 IRQFFYDIIHPEYSPVCDVYALMFLIDVVNFIIIIFGYWAFGKHSAAADIT-ESLSEDQVPEAFLVMLLIQFSTMIVDRALYLRKTLLGKCVFQVVLVFGIHFWMFFILPGVTERRFNRNRVAQLWYFVKCIYFGLSAYQIKCGYPNRVLGNFLTKNHNYFNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSNWICVEDIYANIFILKCWREAEKKYPHRRGQRKKKVVKYTMGGFIIFALICIVWFPLLFMSLVKSVAGVTNQPLDVSIQLSILGYE 287
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 514.998 bits (1325), Expect = 5.542e-155 Identity = 301/766 (39.30%), Postives = 451/766 (58.88%), Query Frame = 3
Query: 1278 LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVD-PLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWR--DHTEFAQDLEIVDKEQDGRNKIKSSY-----EESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLH--QNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
L +L N + SE VCYF++ILNHM+S ++ +L P+++FLWAMLSVPRPSK FW+ I YTE+ IVIKY FQF F +N+ + D P + P I+GIEK + Y DL+QLL +F HR LK +GLW D TE A D + D E + + S+ P+ PI R+F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P F+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ QL YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S+++N ++ L F+ + +K + P+ +L+S+ +D T ++ S+++W I+PP + E+L + P + + I R+ S N + F+ ++ I+P L A ++ LH + NT ++ WW VN Q D L +++F++++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 1214 LIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNKNVDYTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLWDEDDVTEKATDKDDTDGEISEASGRRDSFFILYILCFFPSRILQIYVPI---RQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPPSRTMMIERL--------------IQEPDFTAVISWSIRRYIISSLFYN---------LPNSFSYRPIF--HIYPLCLKA-PSDVTAKPILHVLLRKENT---------SEGVREWWVVN---QSHKEFIKKDG-------LELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTR 1929
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 513.842 bits (1322), Expect = 4.516e-154 Identity = 310/828 (37.44%), Postives = 468/828 (56.52%), Query Frame = 3
Query: 1191 GSHSFVNSKNQEEYLKEQEXXXXXXXXXL-LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVD-PLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWR--DHTEFAQDLEIVDKE-------QDGRNKIKSSY-------------EESSPTSNKWSCNP--------------IY-KMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDN----AMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
S +N +E L++ E + L L +L N + SE VCYF++ILNHM+S ++ +L P+++FLWAMLSVPRPSK FW+ I YTE+ IVIKY FQF F +N+ + D P + P I+GIEK + Y DL+QLL +F HR LK +GLW D TE A D + D E +D +KS EE + K + + IY +R+F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P F+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ QL YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S+++N ++ L F+ + +K + P+ +L+S+ +D T ++ S+++W I+PP + E+L + P + + I R ++ EK ++ +T E + NQ ++NIS+ ++ +N WW VN Q D L +++F++++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 1290 ASELLLNKMFYDEELEDSEKFYTTQPRPLQLIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNKNVDYTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLWDEDDVTEKATDKDDTDGEISEASGRRDSVGSLKSVNLAASVESVHVHFPEEKTAIRRKSTSSGSQISRRSSYSSILQIYVPIRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPPSRTMMIERL--------------IQEPDFTAVISWSI-RSLGAKAEVTGEKYT-----------------------ISLAGQTRRELADMMNNQE--FVNISVLLRKENTSEGVREWWVVN---QSHKEFIKKDG-------LELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTR 2065
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 512.301 bits (1318), Expect = 7.804e-154 Identity = 304/798 (38.10%), Postives = 457/798 (57.27%), Query Frame = 3
Query: 1278 LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVD-PLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWR--DHTEFAQDLEIVDKE-------QDGRNKIKSSY-------------EESSPTSNKWSCNP--------------IY-KMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDN----AMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
L +L N + SE VCYF++ILNHM+S ++ +L P+++FLWAMLSVPRPSK FW+ I YTE+ IVIKY FQF F +N+ + D P + P I+GIEK + Y DL+QLL +F HR LK +GLW D TE A D + D E +D +KS EE + K + + IY +R+F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P F+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ QL YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S+++N ++ L F+ + +K + P+ +L+S+ +D T ++ S+++W I+PP + E+L + P + + I R ++ EK ++ +T E + NQ ++NIS+ ++ +N WW VN Q D L +++F++++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 1246 LIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNKNVDYTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLWDEDDVTEKATDKDDTDGEISEASGRRDSVGSLKSVNLAASVESVHVHFPEEKTAIRRKSTSSGSQISRRSSYSSILQIYVPIRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPPSRTMMIERL--------------IQEPDFTAVISWSI-RSLGAKAEVTGEKYT-----------------------ISLAGQTRRELADMMNNQE--FVNISVLLRKENTSEGVREWWVVN---QSHKEFIKKDG-------LELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTR 1991
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: chordc1 (cysteine and histidine rich domain containing 1 [Source:Xenbase;Acc:XB-GENE-962949]) HSP 1 Score: 476.478 bits (1225), Expect = 1.059e-140 Identity = 297/805 (36.89%), Postives = 469/805 (58.26%), Query Frame = 3
Query: 1278 LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW------------------RDHTEFAQDLEIVDK-----EQDGRNKIKSSYEESSPTSNKWSC-------NPIYK-MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKI----NMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ---NQNNTYLNISLSM---------KTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWT 3539
L ++L N +SE +CYF++ILN+M+S +L SL P+++FLW MLS+ +PSK FW+ I +TE+++VIKY+FQF F +N T + P + P ++G+EKS +Y DLIQLL +F HR L + GLW + + +QDLE Q R + + S +E SN W+C IY+ ++ F+ + + K DVY FMFL + + F+II+FG+ +FG + +AD A + +++P F+ M++ QF ++IDRAL+LRK V GK IFQ+ V+ IH W+FF LP +T++ FN QL YFVKCIYFALSAYQ++ GYP RILGNFLT+ +N++NLFLF+G+ +VPFL ELR VMDW+WTD++++ +WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI++F IW PL+ S + + V PI+ + + +G Y PLF S+++ +++P T + +E + + + ++ + +D I+ +S +VW I+PP ++++++L + + + + Q + T ++EK + + E A+LL + T V + +FP+++ A EAN + Q ++ +YL++ + + T + + WW + D + L + IFN+++S G + + YGI+G+Y + V+ +F+R F+S IS+ I EELP VDRI KL +IY+VRE +L LEE+L AKLIFLYRS ETMIKWT
Sbjct: 1368 LLLALYNFVAAHSELLCYFIIILNNMVSASLISLFLPILIFLWGMLSIHKPSKRFWMTAIIFTEVMVVIKYLFQFGFFPWNNYTILVRNEGKPFFPPRVLGLEKSDSYIKYDLIQLLMLFFHRSLLMSYGLWDRKDLDLEERTPGKDKGSKTEIQASQDLEPAGGSSSSLRQRKRKESQGSVQERGAESN-WTCAVQFTSLRNIYQPVKAFFHDILHTKNRAATDVYAFMFLADVVDFVIIVFGFWAFGKHSAAADIASS-LSDDQVPEAFLVMVLIQFSTMVIDRALYLRKTVLGKLIFQVILVIGIHVWMFFILPAVTERMFNQNTVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIIVFLICIIWFPLLFMSLVRSVVGVVNHPIDVTVTFKLGGYEPLFTMSAQQQSIQPFTPQQYEALTYEFERQPTAMQFITLYSYEDIVTARIEGSSGSVWGISPPSREQMRKELQNGSSDITLRFTWDFQRDLAKGGTVEHTSEKHTKDLEPGSQERMELADLLQGV----RDTPVSIQHLFPKYIRAPNG--PEANPVKQLQPDEEESYLDVEVQLNRMRVAEGNSTSSFVEWWVITL----------KDCEGEDCNILPMVIFNDKVSPPSLGFL-AGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIYVVRERGELELEEELYAKLIFLYRSPETMIKWT 2153
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: chordc1 (cysteine and histidine rich domain containing 1 [Source:Xenbase;Acc:XB-GENE-962949]) HSP 1 Score: 476.478 bits (1225), Expect = 1.204e-140 Identity = 297/805 (36.89%), Postives = 469/805 (58.26%), Query Frame = 3
Query: 1278 LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW------------------RDHTEFAQDLEIVDK-----EQDGRNKIKSSYEESSPTSNKWSC-------NPIYK-MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKI----NMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ---NQNNTYLNISLSM---------KTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWT 3539
L ++L N +SE +CYF++ILN+M+S +L SL P+++FLW MLS+ +PSK FW+ I +TE+++VIKY+FQF F +N T + P + P ++G+EKS +Y DLIQLL +F HR L + GLW + + +QDLE Q R + + S +E SN W+C IY+ ++ F+ + + K DVY FMFL + + F+II+FG+ +FG + +AD A + +++P F+ M++ QF ++IDRAL+LRK V GK IFQ+ V+ IH W+FF LP +T++ FN QL YFVKCIYFALSAYQ++ GYP RILGNFLT+ +N++NLFLF+G+ +VPFL ELR VMDW+WTD++++ +WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI++F IW PL+ S + + V PI+ + + +G Y PLF S+++ +++P T + +E + + + ++ + +D I+ +S +VW I+PP ++++++L + + + + Q + T ++EK + + E A+LL + T V + +FP+++ A EAN + Q ++ +YL++ + + T + + WW + D + L + IFN+++S G + + YGI+G+Y + V+ +F+R F+S IS+ I EELP VDRI KL +IY+VRE +L LEE+L AKLIFLYRS ETMIKWT
Sbjct: 1420 LLLALYNFVAAHSELLCYFIIILNNMVSASLISLFLPILIFLWGMLSIHKPSKRFWMTAIIFTEVMVVIKYLFQFGFFPWNNYTILVRNEGKPFFPPRVLGLEKSDSYIKYDLIQLLMLFFHRSLLMSYGLWDRKDLDLEERTPGKDKGSKTEIQASQDLEPAGGSSSSLRQRKRKESQGSVQERGAESN-WTCAVQFTSLRNIYQPVKAFFHDILHTKNRAATDVYAFMFLADVVDFVIIVFGFWAFGKHSAAADIASS-LSDDQVPEAFLVMVLIQFSTMVIDRALYLRKTVLGKLIFQVILVIGIHVWMFFILPAVTERMFNQNTVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIIVFLICIIWFPLLFMSLVRSVVGVVNHPIDVTVTFKLGGYEPLFTMSAQQQSIQPFTPQQYEALTYEFERQPTAMQFITLYSYEDIVTARIEGSSGSVWGISPPSREQMRKELQNGSSDITLRFTWDFQRDLAKGGTVEHTSEKHTKDLEPGSQERMELADLLQGV----RDTPVSIQHLFPKYIRAPNG--PEANPVKQLQPDEEESYLDVEVQLNRMRVAEGNSTSSFVEWWVITL----------KDCEGEDCNILPMVIFNDKVSPPSLGFL-AGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIYVVRERGELELEEELYAKLIFLYRSPETMIKWT 2205
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 422.935 bits (1086), Expect = 2.363e-122 Identity = 226/591 (38.24%), Postives = 367/591 (62.10%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI---NTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMM----WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+R+F+ + +P ++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ + QL YFVKC+YF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S++++ ++ + + E + + + +L+++E +D T ++ S+++W I+PP +K+ ++L+ P + + +R T E I S L + ++ +I +T+ ++T V + I+P ++ A + S+ ++NN ++NI++ + DN WW +N + G S N S + L + +FN+++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2197 IRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMTLGAKAE-IATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMNITIILFRDNVTKSNSEWWVLN--LTG-SRIFNQGSQA-----LELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2775 HSP 2 Score: 107.457 bits (267), Expect = 1.030e-22 Identity = 72/151 (47.68%), Postives = 97/151 (64.24%), Query Frame = 3
Query: 1275 LLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFN---ETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQD 1718
LL ++ N + SE VCYF++ILNHM S ++ +L P+++FLWAMLSVPRPS+ FW+ I YTE+ IV+KY FQF F +N E +R P + P IIG+EK + Y + DLIQLL +F HR LK +GLW + +IVD D
Sbjct: 1935 LLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKER--PYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDED-------DIVDSNTD 2076
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 422.935 bits (1086), Expect = 2.549e-122 Identity = 226/591 (38.24%), Postives = 367/591 (62.10%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI---NTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMM----WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+R+F+ + +P ++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ + QL YFVKC+YF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S++++ ++ + + E + + + +L+++E +D T ++ S+++W I+PP +K+ ++L+ P + + +R T E I S L + ++ +I +T+ ++T V + I+P ++ A + S+ ++NN ++NI++ + DN WW +N + G S N S + L + +FN+++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2172 IRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMTLGAKAE-IATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMNITIILFRDNVTKSNSEWWVLN--LTG-SRIFNQGSQA-----LELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2750 HSP 2 Score: 107.457 bits (267), Expect = 1.020e-22 Identity = 72/151 (47.68%), Postives = 97/151 (64.24%), Query Frame = 3
Query: 1275 LLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFN---ETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQD 1718
LL ++ N + SE VCYF++ILNHM S ++ +L P+++FLWAMLSVPRPS+ FW+ I YTE+ IV+KY FQF F +N E +R P + P IIG+EK + Y + DLIQLL +F HR LK +GLW + +IVD D
Sbjct: 1910 LLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKER--PYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDED-------DIVDSNTD 2051
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 422.55 bits (1085), Expect = 2.877e-122 Identity = 226/591 (38.24%), Postives = 367/591 (62.10%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI---NTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMM----WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+R+F+ + +P ++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ + QL YFVKC+YF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S++++ ++ + + E + + + +L+++E +D T ++ S+++W I+PP +K+ ++L+ P + + +R T E I S L + ++ +I +T+ ++T V + I+P ++ A + S+ ++NN ++NI++ + DN WW +N + G S N S + L + +FN+++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2243 IRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMTLGAKAE-IATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMNITIILFRDNVTKSNSEWWVLN--LTG-SRIFNQGSQA-----LELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2821 HSP 2 Score: 107.457 bits (267), Expect = 1.034e-22 Identity = 72/151 (47.68%), Postives = 97/151 (64.24%), Query Frame = 3
Query: 1275 LLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFN---ETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQD 1718
LL ++ N + SE VCYF++ILNHM S ++ +L P+++FLWAMLSVPRPS+ FW+ I YTE+ IV+KY FQF F +N E +R P + P IIG+EK + Y + DLIQLL +F HR LK +GLW + +IVD D
Sbjct: 1981 LLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKER--PYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDED-------DIVDSNTD 2122
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:MGI Symbol;Acc:MGI:3603204]) HSP 1 Score: 366.696 bits (940), Expect = 6.704e-104 Identity = 225/606 (37.13%), Postives = 359/606 (59.24%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKI----NMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ---NQNNTYLNISLSM----------------KTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
++RF+ + + K+ DVY MFL + + +IIIFG+ +FG + + D A + +++P F+ M++ QF ++IDRAL+LRK V GK FQ+ V+ IH W+FF LP +T++ F+ QL YFVKCIYFALSAYQ++ GYP RILGNFLT+ +N++NLFLF+G+ +VPFL ELR VMDW+WTD++++ +WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI++F IW PL+ S I + V PI+ + ++ +G Y PLF S+++ ++ P T + +EE+ + + + ++ + P+D I+ +S +W I+PP ++K++L A + + N Q + T + EK T + + L L+ + + + V +P +FP+++ A EAN + Q ++ YL + + + K + + WW V E+ ++ C L + IF++++S G + + YGI+G+Y + VV +F+R F+S IS+ I EELP VDRI KL +I+LVRE ++L LEE+L AKLIFLYRS ETMIKWT+
Sbjct: 1958 LQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFGKHSAATDIASS-LSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEK---HTLELAPNSTARRQLAQLLEGRPDQS-VVIPHLFPKYIRAPNG--PEANPVKQLQPDEEEDYLGVRIQLRREQVGTGASGEQAGTKASDFLEWW-VIELQDCKADCN----------LLPMVIFSDKVSPPSLGFL-AGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTR 2544 HSP 2 Score: 114.39 bits (285), Expect = 7.369e-25 Identity = 76/229 (33.19%), Postives = 122/229 (53.28%), Query Frame = 3
Query: 1125 KISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXXXXXXXXXLLAISLG-NVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRV---DPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTE--FAQD-LEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPI 1790
+ + G EL A + S ++ + L+E E ++ L + G +SE +CYF++ILNHM++ + SL P++VFLWAML++PRPSK FW+ I +TE+++V KY+FQF F +N R P + P I+G+EK+ +Y DL+QL+ +F HR L GLW DH E + +D K+++ + + ++ E S T P+
Sbjct: 1623 QAGTSLHGSQELLANARTRMRTASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLW-DHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPV 1850
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:MGI Symbol;Acc:MGI:3603204]) HSP 1 Score: 366.696 bits (940), Expect = 7.338e-104 Identity = 225/606 (37.13%), Postives = 359/606 (59.24%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKI----NMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ---NQNNTYLNISLSM----------------KTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
++RF+ + + K+ DVY MFL + + +IIIFG+ +FG + + D A + +++P F+ M++ QF ++IDRAL+LRK V GK FQ+ V+ IH W+FF LP +T++ F+ QL YFVKCIYFALSAYQ++ GYP RILGNFLT+ +N++NLFLF+G+ +VPFL ELR VMDW+WTD++++ +WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI++F IW PL+ S I + V PI+ + ++ +G Y PLF S+++ ++ P T + +EE+ + + + ++ + P+D I+ +S +W I+PP ++K++L A + + N Q + T + EK T + + L L+ + + + V +P +FP+++ A EAN + Q ++ YL + + + K + + WW V E+ ++ C L + IF++++S G + + YGI+G+Y + VV +F+R F+S IS+ I EELP VDRI KL +I+LVRE ++L LEE+L AKLIFLYRS ETMIKWT+
Sbjct: 1957 LQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFGKHSAATDIASS-LSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEK---HTLELAPNSTARRQLAQLLEGRPDQS-VVIPHLFPKYIRAPNG--PEANPVKQLQPDEEEDYLGVRIQLRREQVGTGASGEQAGTKASDFLEWW-VIELQDCKADCN----------LLPMVIFSDKVSPPSLGFL-AGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTR 2543 HSP 2 Score: 114.39 bits (285), Expect = 7.184e-25 Identity = 76/229 (33.19%), Postives = 122/229 (53.28%), Query Frame = 3
Query: 1125 KISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXXXXXXXXXLLAISLG-NVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRV---DPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTE--FAQD-LEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPI 1790
+ + G EL A + S ++ + L+E E ++ L + G +SE +CYF++ILNHM++ + SL P++VFLWAML++PRPSK FW+ I +TE+++V KY+FQF F +N R P + P I+G+EK+ +Y DL+QL+ +F HR L GLW DH E + +D K+++ + + ++ E S T P+
Sbjct: 1622 QAGTSLHGSQELLANARTRMRTASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLW-DHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPV 1849
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q9H5I5|PIEZ2_HUMAN (Piezo-type mechanosensitive ion channel component 2 OS=Homo sapiens OX=9606 GN=PIEZO2 PE=1 SV=2) HSP 1 Score: 429.869 bits (1104), Expect = 7.016e-124 Identity = 226/591 (38.24%), Postives = 371/591 (62.77%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI---NTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMM----WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+++F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ + QL YFVKC+YF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S++++ ++ + +++F + + + +L+++E +D T ++ S+++W I+PP +K+ +L P +S + +R + +E I S L N + N+ +I +T+ + T V + I+P ++ A + S+ ++NN +++I++ + DN WW +N + + Y PN + L + +FN+++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2171 IKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSE-IATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLN-LTGNRIYNPNSQA-------LELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2749 HSP 2 Score: 125.946 bits (315), Expect = 1.543e-27 Identity = 76/165 (46.06%), Postives = 102/165 (61.82%), Query Frame = 3
Query: 1275 LLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVD-PLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW--RDHTEFAQDLEIVDKE-------QDGRNKIKS 1739
LL ++ N + SE VCYF++ILNHM+S ++ +L P+++FLWAMLSVPRPS+ FW+ I YTE+ IV+KY FQF F +N+ D P P IIG+EK + Y + DLIQLL +F HR LK +GLW D TE E D E +D + +KS
Sbjct: 1909 LLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKS 2073
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|M9MSG8|PIEZO_DROME (Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster OX=7227 GN=Piezo PE=2 SV=1) HSP 1 Score: 425.631 bits (1093), Expect = 2.174e-122 Identity = 261/809 (32.26%), Postives = 433/809 (53.52%), Query Frame = 3
Query: 1314 SEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFI--SFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRD-----HTEFAQDLEIVDKEQDGRN---------------KIKSSYEESS-PTSNKWSCNPIYKMRR----------FYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPG-TDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCER--PSTDSK---STEKIVRFTQSRFLTNPEKANLLHLI-----------NTKFNSTN------VYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAM--MWWEVNEIIQGQSYCPNP--DSPSKKYLF------LTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
++ +CY ++ +N +++ +L SLP P+MVFLW LS+PRP+K FW+ LI YT+ +++IK IFQF I ++++ N PL I G+E +YAI DLI LL +FLHR LK+ GLW+ +F + +D+ D N K+ ++S P S ++S I ++ R F+S + + DVY MFLC+F+ F +++FG+ +FG T+S + ++ NK+P+PF+ M++ QF+ I+IDRAL+LRK + K IF F V+ IH W+FF +P +T++ FNS P + Y +KC Y LS+YQ+KSGYP RILGNF T+ F+ +N+ FK YM +PFLYELR ++DW+ DS++ + W+++EDIFS I++++C R ET +P R + + + K +G I++ CIWGPL + + P S SI +G Y P++ ++ +++ + + + +M + + ++ ++ D + + S ++W I PP ++L L +LK R P+ K E + +S +A L+H++ N N T V +P + P+F+ + S+ ++ Y + + M DN +WWE+ + YC + + K+ + + ++ FN++ + F + ++ GI+G+Y + + RF+++F + I E+LP VDR+ +L +IYLVRE + LEE L AKL+FLYRS ET+IKWT+
Sbjct: 1728 TDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKSRL--ATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPIYT-TNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLR-NNHTLKARFSYSLTRKAPAKGLKENVGDEHAISLDESF----EGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRD------YCNDTFYNETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFL-TAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2518
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q8CD54|PIEZ2_MOUSE (Piezo-type mechanosensitive ion channel component 2 OS=Mus musculus OX=10090 GN=Piezo2 PE=1 SV=2) HSP 1 Score: 422.55 bits (1085), Expect = 2.011e-121 Identity = 226/591 (38.24%), Postives = 367/591 (62.10%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLI---NTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMM----WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+R+F+ + +P ++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T++KF+ + QL YFVKC+YF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VKY +G +I++ +W PL+ S I + V P++ S +I +G Y P+F S++++ ++ + + E + + + +L+++E +D T ++ S+++W I+PP +K+ ++L+ P + + +R T E I S L + ++ +I +T+ ++T V + I+P ++ A + S+ ++NN ++NI++ + DN WW +N + G S N S + L + +FN+++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2241 IRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMTLGAKAE-IATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMNITIILFRDNVTKSNSEWWVLN--LTG-SRIFNQGSQA-----LELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2819 HSP 2 Score: 107.457 bits (267), Expect = 7.170e-22 Identity = 72/151 (47.68%), Postives = 97/151 (64.24%), Query Frame = 3
Query: 1275 LLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFN---ETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQD 1718
LL ++ N + SE VCYF++ILNHM S ++ +L P+++FLWAMLSVPRPS+ FW+ I YTE+ IV+KY FQF F +N E +R P + P IIG+EK + Y + DLIQLL +F HR LK +GLW + +IVD D
Sbjct: 1979 LLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKER--PYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDED-------DIVDSNTD 2120
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q92508|PIEZ1_HUMAN (Piezo-type mechanosensitive ion channel component 1 OS=Homo sapiens OX=9606 GN=PIEZO1 PE=1 SV=4) HSP 1 Score: 387.497 bits (994), Expect = 8.888e-110 Identity = 225/596 (37.75%), Postives = 357/596 (59.90%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKI----NMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ---NQNNTYLNISLSMKTDNA------MMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
+RRF+ + + K+ DVY MFL + + F+IIIFG+ +FG + + D + +++P F+ M++ QF +++DRAL+LRK V GK FQ+ VL IH W+FF LP +T++ FN + QL YFVKCIYFALSAYQ++ GYP RILGNFLT+ +N++NLFLF+G+ +VPFL ELR VMDW+WTD++++ WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI++F IW PL+ S + + V PI+ + ++ +G Y PLF S+++ ++ P T + +EE+ + ++ + P+D I+ +S +W I+PP ++K +L A + + N Q + T + EK + + A+LL + + +V +P +FP+++ A EAN + Q N+ YL + + ++ + + WW V E+ + ++ C L + IF++++S G + + YGI+G+Y + V+ +F+R F+S IS+ I EELP VDRI KL +I+LVRE ++L LEE+L AKLIFLYRS ETMIKWT+
Sbjct: 1942 LRRFFHDILHTKYRAATDVYALMFLADVVDFIIIIFGFWAFGKHSAATDITSS-LSDDQVPEAFLVMLLIQFSTMVVDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSSWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQ----SVVIPNLFPKYIRAPNG--PEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWW-VIELQECRTDCN----------LLPMVIFSDKVSPPSLGFL-AGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTR 2518 HSP 2 Score: 115.161 bits (287), Expect = 3.150e-24 Identity = 62/126 (49.21%), Postives = 85/126 (67.46%), Query Frame = 3
Query: 1311 YSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRV---DPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTE 1679
+SE +CYF++ILNHM++ + SL P++VFLWAMLS+PRPSK FW+ I +TEI +V+KY+FQF F +N R P + P I+G+EK+ Y DL+QL+ +F HR L GLW DH E
Sbjct: 1686 HSELLCYFIIILNHMVTASAGSLVLPVLVFLWAMLSIPRPSKRFWMTAIVFTEIAVVVKYLFQFGFFPWNSHVVLRRYENKPYFPPRILGLEKTDGYIKYDLVQLMALFFHRSQLLCYGLW-DHEE 1810
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q0KL00|PIEZ1_RAT (Piezo-type mechanosensitive ion channel component 1 OS=Rattus norvegicus OX=10116 GN=Piezo1 PE=1 SV=3) HSP 1 Score: 375.941 bits (964), Expect = 5.571e-106 Identity = 223/603 (36.98%), Postives = 355/603 (58.87%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKI-VRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQ---NQNNTYLNISLSM----------------KTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
+RRF+ + + K+ DVY MFL + + ++IIFG+ +FG + + D A + +++P F+ M++ QF ++IDRAL+LRK V G FQ+ V+ IH W+FF LP +T++ F QL YFVKCIYFALSAYQ++ GYP RILGNFLT+ +N++NLFLF+G+ +VPFL ELR VMDW+WTD++++ +WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI++F IW PL+ S I + V PI+ + ++ +G Y PLF S+++ ++ P T + +EE+ + + + ++ + P+D I+ +S +W I+PP ++K +L A + + +R S E + T + + L L+ + + + V +P +FP+++ A EAN + Q ++ YL + + + K + + WW V E+ Q+ C L + IF++++S G + + YGI+G+Y + VV +F+R F+S+IS+ I EELP VDRI KL +I+LVRE ++L LEE+L AKLIFLYRS ETMIKWT+
Sbjct: 1946 LRRFFHDILHTKYRAATDVYALMFLADIVDIVVIIFGFWAFGKHSAATDIASS-LSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGNLAFQVVLVVAIHLWMFFILPAVTERMFRQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPEDYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKHELYNGTADITLRFTWNFQRDLAKGGSVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQS-VVIPHLFPKYIRAPNG--PEANPVKQLQPDEEEDYLGVRIQLRREQVGTGTSGEQAGTKASDFLEWW-VIELQDCQAECN----------LLPMVIFSDKVSPPSLGFL-AGYGIVGLYVSIVLVVGKFVRGFFSDISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTR 2532 HSP 2 Score: 113.235 bits (282), Expect = 1.101e-23 Identity = 65/166 (39.16%), Postives = 98/166 (59.04%), Query Frame = 3
Query: 1311 YSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRV---DPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFA---QDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPI 1790
+SE +CYF++ILNHM++ + SL P++VFLWAML++PRPSK FW+ I +TE+++V KY+FQF F +N R P + P I+G+EK+ +Y DL+QL+ +F HR L GLW DH E +K+Q+ + ++ E T P+
Sbjct: 1673 HSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYIVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLW-DHEEDGVPKDHCRSSEKDQEAEEESEAKLESQPETGTGHPEEPV 1837
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A504YS87 (Piezo-type mechanosensitive ion channel component OS=Fasciola gigantica OX=46835 GN=FGIG_01349 PE=3 SV=1) HSP 1 Score: 888.641 bits (2295), Expect = 0.000e+0 Identity = 483/985 (49.04%), Postives = 639/985 (64.87%), Query Frame = 3
Query: 918 DETDKKIEKPAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKI-SNEVDGRIELEAIVVEIVGDGSHSF-------------------------------VNSKNQEEYLKEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFN---ETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKE-----------------------------QDGRNKIKSSYEE-------SSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINT-----------------KFNSTN-VYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTD--NAMMWWEVN------------EIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLE 3563
D T I++ E CWSKFKAS +I Y FI ++ D+LI L+N T++YRRIRRT+D EKRLVK ++++ I + + R LEA + E+V + + + S Q Y +E+ FR+SRS FLL I++GN+AI+YSE+ CYFLLILNHM S + SLPYPL VFLW MLSVPRP+K FWI LITYTE+VIVIKYIFQF FI FN E + + LW+P + G++K+ +YA+ DLIQL+ +FLHRGYLKNNGLWRDHTEFAQDLE+V +E ++ N++ S+ ++ S T W NP K+ RFY KMT+P++NKKVDVY++MFLCEFIAF I+IFGYVSFGP T DNAF+FIK+N+IP+PFI+M++ QF+FIIIDR LFL+KQV GKFIFQI HVLLIH WL F LPHIT+ FN+ +APQLLY +KC+YF+LSAYQ++SGYP RILGNFLT+++NY+NL LFKGY+I+PFLYELRNVMDWMWT S+++ YHWME+EDI++KIFVLKCWR E +PT RG NR K +G L+L FFF C WGP+ +SSFIG TF PP+ C+FSI+ G + P+F F+SRE N+ +++ + K CH+ + +L +FE D I ID S N+W ITPP L+EKL+ ++ L ++ C R + + ++ + V SR L + EK LL ++N F +T+ V L PR++ K L A + Q TY+N+S ++ D WWE+ E+++G + +K L+I +NER+SD++FG +FS+YGI+G+YAAY F+ +R LRT YSNISY+I EELP+VDRI L +EIYLVREN LRLEEQL+AKL FLYRSSETMIKWT+H K ++
Sbjct: 2197 DVTQGSIQQ--REEGCWSKFKASCMIGYMFIISSVDSLIRLLNGLTRQYRRIRRTIDQEKRLVKRRLIANIDATQEHSRHHLEAAMFEVVANTAEQLQPLMRNNVESAPCTNRDLPHEHMRSEHYTVPMGSTYQHHYQREKAFRQSRSHAFLLLIAMGNLAIVYSEWFCYFLLILNHMRSSTILSLPYPLTVFLWGMLSVPRPTKTFWIFLITYTEVVIVIKYIFQFRFIYFNDPLEKPSVSAEALWLPRLFGLDKNDHYALFDLIQLISLFLHRGYLKNNGLWRDHTEFAQDLELVVEENRAAQMRRASRHSVERPKRESSSHAVLEGENSNNQVLSTSQQLSTINPRMSATGKSW--NPFAKLHRFYLKMTDPRYNKKVDVYIYMFLCEFIAFWIMIFGYVSFGPSTGMGDNAFEFIKSNRIPLPFISMLLVQFIFIIIDRGLFLQKQVLGKFIFQIIHVLLIHGWLSFILPHITRSPFNASVAPQLLYLIKCVYFSLSAYQIRSGYPHRILGNFLTKNYNYLNLILFKGYLIIPFLYELRNVMDWMWTRSALSLYHWMELEDIYAKIFVLKCWRRSEIAYPTPRGVNRPAGKKALVGGLLLSFFFLCFWGPMALSSFIGATFDFNPPVLCTFSISFGGFPPIFEFTSREGNILRISESVHLDFKRCHEKDKQTFGFLNNFEAKDVRYITIDGFSGNIWAITPPSHSTLREKLADSKSDLLLHFHMRCRRHTKEIQTGQTSVEDIFSRRLGSNEKHQLLRVLNQSTSVEGLEESASSQEEPSFRTTDPVVLDATMPRYVLLRKDRLRAAYA-KLGQKETYVNVSFNIHHDRLQTQSWWELKEREGPEPVDPCFEVLRGSVLGSKQRAAAK---VLSIVTYNERVSDSLFGKVFSNYGIIGMYAAYIFLANRLLRTIYSNISYVIRLEELPHVDRILNLCNEIYLVRENNLLRLEEQLVAKLFFLYRSSETMIKWTRHPKHIID 3173
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A4S2LHK5 (Piezo-type mechanosensitive ion channel component OS=Opisthorchis felineus OX=147828 GN=CRM22_007115 PE=3 SV=1) HSP 1 Score: 853.203 bits (2203), Expect = 0.000e+0 Identity = 486/997 (48.75%), Postives = 639/997 (64.09%), Query Frame = 3
Query: 837 ESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKPA---HPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVG------DGSHSFVNSKNQE------------EYL--------KEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIV-----------DKEQDGRNKIKSSYEESSP------------TSNKWSC---------NPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTK-----------------FNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNA--MMWWEVNE-IIQGQSYCPN----PDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLE 3563
E P + T SS S+ S D+ PA E CWSKFKA L+ Y F+ ++ D+LI L+N TK YR IRR ++ EKR VKL V++ + +++E V +V G F++ + + E+L +E+ FR+SRSR FLL I+LGN+AI+YSE+ CY LL++NHM S N+ SL YPL+VFLW MLSVPRP+K FWI LITYTE+VIVIKYIFQF FI+FN+ + D + LWIP ++G+EKS +YAI DL+QL+ +FLHRG+LKN+GLWRDHTEF QDL++V + EQ G + ++ ES+ TS + + NP K+RRFY KMT+P+FNKKVDVY++MFLCEFI+F II+FGYVSFGP T DNAF+FI++N++P PF+ M++ QF+FIIIDR LFLRKQV GKFIFQI HVLLIH WLFF LPHITK F + APQLLY +KC+YF+LSAYQ++SGYPLRILGNFLT+ +NYINL LFKGY+IVPFLYELRN+MDWMWT+S+++ YHWME+ED+++KIFV KCWR E +PT RG NR K +G LIL FFF C+W PL +SSFIG TFV PP+ C+FS+++G + P+F F+SRE N+ + ++ + CH+ L + +L +FE DD I ID S N+W ITPP L +KLS + L ++ C R + + ++++ V SR L EK L ++NT +S+ V L + PR+L + L A + + NTY+N+S + D A WWE+ E I C P L+I FNER+SD++FG F +YGILG+Y AY F+V+R RT Y+NISY+I EELP+VDRI L +EIYLVRENK LRLEEQL+AKL FLYRSSETMIKWT+H K ++
Sbjct: 2173 EKRAAGKPAMLAFTRSSSKSLDNPDSEDQLGDDSNTPAAQQREEGCWSKFKAFCLVTYLFLLSSVDSLIYLLNGLTKHYRNIRRRIEREKRCVKLNVINNTQHPEQSPLDIEVAVFNVVSKSPEHVSGGVPFLDPQISDRCRAALVPGQSIEHLDALDRHQQREKAFRQSRSRPFLLLIALGNMAIVYSEWFCYLLLVVNHMRSSNILSLVYPLVVFLWGMLSVPRPTKTFWIFLITYTEVVIVIKYIFQFRFITFNDPSLKPADSAEALWIPRLLGVEKSGHYAIFDLVQLISLFLHRGFLKNDGLWRDHTEFVQDLQLVAERNKVAERVQNGEQVGPDFLRLLSTESAASQMVEGHNVDAVTSGRLTVSRRDALHTWNPFAKLRRFYHKMTDPQFNKKVDVYIYMFLCEFISFWIIMFGYVSFGPSTGMGDNAFEFIRSNRVPFPFVCMLLVQFIFIIIDRGLFLRKQVLGKFIFQILHVLLIHGWLFFILPHITKSPFTAGFAPQLLYLIKCVYFSLSAYQIRSGYPLRILGNFLTKKYNYINLILFKGYLIVPFLYELRNIMDWMWTNSTLSLYHWMELEDVYAKIFVHKCWRRSEIAYPTPRGVNRPAGKKALVGGLILAFFFACLWIPLALSSFIGATFVFNPPVLCTFSLSIGGFPPVFEFTSREGNILKIRQQDLDSFTRCHEKDLQTVGFLNNFEVDDLRYITIDGFSGNIWAITPPSYDTLVKKLSDASSDLLLHSHMQCRRKTKEIQTSQISVEDIFSRKLQPLEKIELYDVLNTTAVGSAANNTQVKLSSRVLSSSPVTLNAVMPRYLVLKRDRLRPAYAT-LGRENTYINVSFVIHRDPAKNQSWWELKERAITSSDACFEKLRFPTLGDSWADALSIMTFNERVSDSLFGKWFFTYGILGMYGAYLFLVNRLFRTVYTNISYVIRLEELPHVDRILNLCNEIYLVRENKLLRLEEQLVAKLFFLYRSSETMIKWTRHPKRIID 3168
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A4Z2DRN6 (Piezo-type mechanosensitive ion channel component OS=Schistosoma japonicum OX=6182 GN=EWB00_009369 PE=3 SV=1) HSP 1 Score: 852.047 bits (2200), Expect = 0.000e+0 Identity = 494/1063 (46.47%), Postives = 654/1063 (61.52%), Query Frame = 3
Query: 771 QDNQLTNDQAQLSLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKPAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSK--ISNEVDGRIELEAIVVEIVG----------DGSHSFVNSKNQ-------------------------EEYLKEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQDG---------------------RNKIKS------------------SYEESS----PTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINT----------KFNST--------------------NVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTD--NAMMWWEVNEIIQGQSYCPNPDSPSKKYLF-----------------LTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLE 3563
QD+Q+ + + N S+ + + + D N + N+ P D+T ++ H ESCWSKFKAS LI Y F ++ D+LI +N T++YRRIRRT+D EKRLVK +V+S +NE R++LEA V+EI+ H N +N +++ +E+ FR+SRS FLL I++GN+AI+YSE CYFLLI NHM S +L SLPYPLMV LW MLSVPRP+K FWI LITYTEIVIVIKYIFQF F FN+ T + + LW+P I+GI K+ +YA+ DL+QL+ +FLHRGYLKNNGLWRD+TEF DLE++ +E NK+K+ Y +SS PT+ + NP+ K++RFY KMT+P++NKKVDVY++MFLCEFIAF II+FGYVSFGP T DNAF+F+K+N+IP PFI+M++ QF+FIIIDR LFL+KQV GKFIFQI HV+LIH WLFF LPHIT+ F S +APQLLY +KC+YF+LSAYQ++SGYP RILGNFLT+++NYINL LFKGY+++PFLYELRNVMDWMWT S+++ YHWME+ED++SKIF+LKCWR E +PT RG+NR + K G L+L+FFF C WGP+ ++SFIG TF PP+ C+FS + G + P F F+SRE N+ + CH+ + +L +FE +D + ID S N+W ITPP + L KL + L ++ C R + + +S+ V SR L+ EK LL ++N+ K N+T +V L + PR++ K L A + N TY+N+S M D + WWE+ E +SP+ F L+I FNER+SD++FG +F++YGI+G+YAAY F+ R LRT YSNISY+I EELP+VDRI L HEIYLVREN L LEEQL+AKL FLYRSSETMIKWT+H K +E
Sbjct: 2187 QDDQIITQRK------FVKNIHSSQPFSDNNGFSDVNDNGNASPY----DKT-RRHSVHQHAESCWSKFKASCLIAYMFFLSSVDSLIRFLNGLTRQYRRIRRTIDQEKRLVKRRVISNNPFTNE-QSRVQLEAAVLEIISTTPERQLSLLSPQHIETNPQNNVKRSSEASDYLIHHNSLDNFDNTDLQDHEREKAFRQSRSYGFLLLIAVGNLAIVYSELFCYFLLIFNHMRSSSLLSLPYPLMVLLWGMLSVPRPTKTFWIFLITYTEIVIVIKYIFQFKFFHFNDATLRPIESAEALWLPRILGINKNDDYAVFDLVQLISLFLHRGYLKNNGLWRDYTEFTHDLELIVQENKAVELSHSKQAICSRPLASSCIYLNKLKTDVDKDDGLYSSVHNTFVQQYPQSSHFPVPTTGGKTWNPLVKLKRFYLKMTDPRYNKKVDVYIYMFLCEFIAFWIILFGYVSFGPSTGMGDNAFEFLKSNRIPFPFISMLLVQFIFIIIDRGLFLQKQVLGKFIFQIIHVVLIHGWLFFILPHITRSPFTSGLAPQLLYLIKCVYFSLSAYQIRSGYPRRILGNFLTKNYNYINLVLFKGYLLLPFLYELRNVMDWMWTSSALSLYHWMELEDVYSKIFILKCWRRSELAYPTPRGQNRDISKKALTGGLLLLFFFICFWGPMALTSFIGATFDVNPPVLCTFSFSFGGFPPTFEFTSREGNIFTVNASELNNFIRCHEKDKQTFGFLHNFEWNDLRYVTIDGFSGNIWAITPPSYQALLMKLRSADSDLLLHFHMKCRRSTKEIQSSHTSVEDIFSRKLSPLEKLQLLMVLNSTNSIFPSSDYKRNTTYTTFINNDNMSTMSHQSRIDSVTLNAVLPRYVLLKKDKLRGAYAFLGNP-QTYVNVSFHMHQDLTSRQAWWELKEKTN--------NSPTSDPCFEVIRHPTLSINAIEANVLSILTFNERVSDSLFGKVFNNYGIIGMYAAYIFLASRLLRTMYSNISYVIRLEELPHVDRILNLCHEIYLVRENNLLLLEEQLVAKLFFLYRSSETMIKWTRHPKHIVE 3228
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A564YVM1 (Piezo_RRas_bdg domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS9946 PE=4 SV=1) HSP 1 Score: 847.425 bits (2188), Expect = 0.000e+0 Identity = 501/1133 (44.22%), Postives = 673/1133 (59.40%), Query Frame = 3
Query: 507 QNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSEHDELSSLPDAYNT-----PPPAHISETTTEDSFHSAAIQDNQLTNDQAQLSLDLYSANTPESEKYLNPLI--YRDTNI--------------SSNSVPELISNDETDKKIEK------PAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDG-RIELEAIVVEIVGDGS----------------------------------------HSFVNSKNQEEYL----KEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPL-----WIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNK---------------IKSSYEESSPTSNKW----SCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLIN----------TKF-NSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDN--AMMWWEVNEIIQGQSYC---------PNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWK 3551
N +NPL L+N+AME G RSA R+++R ++ R S+V G + SE E++ PP +S+ T D + L++ L +T E + N + Y DT++ ++ +P +D+T + + P E CWS+FKA L+++ F+ +T V +N+ T+E+RRIRRT+D EKR VK K L + G R+ LE++V++++ G+ +S E+ L +E+EFRRSR FLL I++GN+ +++SE VCYF+LI+NH+ S N+ SL YPLMVFLW MLSVPRP+K FWI+LITYTE+VI+IKYIFQF FI FN + D+V W+P I G+EK+ +Y I DLIQLLFIF+HR YLKN GLWRD TEF +DL K I S+Y ++S + NPI KMRRFY KMT+P++N+KVDVYV+MF+CEF+AF IIIFGY SFGP T DNAF+FIKTN+IP PFI MII Q VFI++DRALFLRKQV GKFIFQIFHV+LIH +LFF LP IT F A +LYFVKCIYF LSAYQ++SGYP ILGNFLT+++NYINL LFK Y+I+PF+YE+R+VMDWMWTDS ++ YHWME+EDI++K+FV+KCWR E +PT GR R L VKY +G+LIL+F F C WGPL++ SFI TF P+ECS ++ VG + L+ F+SRENN+ + E+++C+ + + ++ +F+ +D + + D S+ +W ITPP ++L +L+ + + I C R + S+ V SR LT+ E+ ++N T F N+ V L FPRFL A K L A S + Q TY+N+S S++TD WW + E+ + C + S LF +I IFNER+SDN+ G IFSSYGI+G+YAAY F R LR YS+ISY I +ELP+VDR+ L H+IYLVREN KL LEE L AKLIFLYRSSETMIKWT+H K
Sbjct: 354 HNHMNPLQLLNQAMEHGMRSAARQYRRRNMVTHQS----RMSTVTDG--MTGQSEESEMAGASSVKQNVVSLRPPRPPLSKQPTLDGTQGGTGTAEAAIGTASNLNV-LNGGSTYEVDPLANKVDDNYYDTDVFDQPDMSPVPLRNGNTGQMPGRAGSDDTLSHLSREVMEGAPGKSEGCWSRFKAGCLVLHIFLLSTIQTTTVWLNSITREHRRIRRTIDIEKRKVKQKALYIFNRSSTGTRVTLESVVLDVISGGASPCQLVPESNAYGGGASGRRRDRQTPAWIEGVPELDDEFQEEMRDSLRSEQALTWEQREREFRRSRPSLFLLLIAVGNLIVVHSELVCYFVLIINHLRSANVISLVYPLMVFLWGMLSVPRPTKTFWISLITYTELVIIIKYIFQFRFIEFN--SPDQVSATLARTHWLPAIFGVEKTDSYGIWDLIQLLFIFMHRSYLKNYGLWRDDTEFKEDLIKAGAANKVNTKRNANQNQNQNNNEDLIVSTYSKASNNQGSSSSSSTLNPITKMRRFYVKMTDPRYNQKVDVYVYMFICEFLAFWIIIFGYQSFGPSTGMGDNAFEFIKTNRIPAPFIGMIIIQSVFIVLDRALFLRKQVLGKFIFQIFHVILIHVYLFFILPQITMTPFTVGSARAVLYFVKCIYFGLSAYQIRSGYPRHILGNFLTKNYNYINLVLFKAYLIMPFVYEVRSVMDWMWTDSPLSLYHWMELEDIYAKVFVMKCWRRSEIEYPTPLGRKRALWVKYLVGMLILLFAFVCFWGPLVVFSFIDTTFAINVPVECSQTLAVGGFPALYFFTSRENNLLHVNGSFLSEIRQCNALNQGTTGFVDNFKTEDVSNMTFDTVSERLWTITPPMYRRLMNELADDSSQMSITFHVTCRRTARPVDSSATRVEQFFSRPLTHKERLEFRAVLNESLALSSPNSTGFTNTKTVRLDLAFPRFLFAQKSNLRNA-SGNLAQPYTYINVSASLETDQYTNQRWWVLEEVGLAGAPCYGSVNNLSEADMHYRSHNRLF-SIIIFNERVSDNLLGKIFSSYGIIGMYAAYIFFASRILRMIYSDISYQISLQELPHVDRLLNLCHDIYLVRENGKLNLEELLFAKLIFLYRSSETMIKWTRHPK 1475
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A3Q0KMS3 (Piezo-type mechanosensitive ion channel component OS=Schistosoma mansoni OX=6183 PE=3 SV=1) HSP 1 Score: 833.943 bits (2153), Expect = 0.000e+0 Identity = 487/1071 (45.47%), Postives = 646/1071 (60.32%), Query Frame = 3
Query: 759 SAAIQDNQLTNDQAQLSLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKPAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKI-SNEVDGRIELEAIVVEIVG---------------------------DGSHSFVNSKNQ-------------EEYLKEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETT---NDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQ---------------------------------------DGRNKIKSSYEESS--PTSNKWSC-----NPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLIN-TKF-------NSTNVY---------------------------LPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTD--NAMMWWEVNEIIQGQSY---C------PNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLE 3563
S AI D Q D + ++ S P + D N SS+ I++++ +K H E CWSKFKAS LI Y F ++ D+LI +N T++YRRIRRT+D EKRLVK +V+S + S R LE+ +EI+ D + ++ N +++ +E+ FR+SRS FLL I++GN+AI+YSE CYFLLI NHM S +L SLPYPLMV LW MLSVPRP+K FWI LITYTEIVIVIKYIFQF F FN+ + +PLW+P IIGI K+ +YA+ DL+QL+ +FLHRGYLKNNGLWRD TEF DLE++ +E G N Y ++S P++ NP+ K++RFY KMT+P++NKKVDVY++MFLCEFIAF I+IFGYVSFGP T DNAF+F+K+N++P+PFI+M++ QF+FII DR LFL+KQV GKFIFQI HV+LIH WLFF LPHIT+ F S +APQLLY +KC+YF+LSAYQ++SGYP RILGNFLT+++NYINL LFKGY++VPFLYELRNVMDWMWT S+++ YHWME+ED++SKIF+LKCWR E +PT RG+NR K G L+L+FFF C WGP+ ++SFIG TF PP+ C+FS + G + P F F+SRE N+ + CH+ + +L +FE +D + ID S N+W ITPP + L KL P + L ++ C R + + +S+ V SR L+ EK LL ++N T F N ++Y L ++ PR++ K L A + + TY+N+S + D + WWE+ E I C P + + + L++ FNER+SD++FG +F++YGI+G+YAAY F+ R LRT YSNISY+I EELP+VDRI L HEIYLVREN L LEEQL+AKL FLYRSSETMIKWT+H K +E
Sbjct: 2155 SYAIMDKQSAEDN---QITVFEKPIKTSHSSSRP--FDDNNGSSD-----INDNDKLRKDSVHQHAEGCWSKFKASCLIAYMFFLSSVDSLIRFLNGLTRQYRRIRRTIDQEKRLVKRRVISYLPSTNEQLRAHLESAALEIISTTPERQLSLFNPQLIERNIQNNEKRSNDTMNPYLIRDNSLDDLDNNTPVTDLQDHEREKAFRQSRSYGFLLLIAVGNLAIVYSELFCYFLLIFNHMHSASLLSLPYPLMVLLWGMLSVPRPTKTFWIFLITYTEIVIVIKYIFQFKFFHFNDAILRPTESAEPLWLPRIIGINKNDDYAVFDLVQLISLFLHRGYLKNNGLWRDDTEFTHDLELIVQENKAAQLSCSKQGTSSRQLASSGVCLNKSKTDLGKDDGLFTGGCNMFVQLYPQTSHYPSTASGGGGGKTWNPLVKLKRFYLKMTDPRYNKKVDVYIYMFLCEFIAFWIMIFGYVSFGPSTGMGDNAFEFLKSNRVPLPFISMLLVQFIFIITDRGLFLQKQVLGKFIFQIIHVVLIHGWLFFILPHITRSPFTSGLAPQLLYLIKCVYFSLSAYQIRSGYPRRILGNFLTKNYNYINLVLFKGYLLVPFLYELRNVMDWMWTSSALSLYHWMELEDVYSKIFILKCWRRSELAYPTPRGQNRDTSKKALTGGLLLLFFFICFWGPMALTSFIGATFDVNPPVLCTFSFSFGGFPPTFEFTSREGNIFTVNSSELNNFIRCHEKDKQTFGFLHNFEWNDLRYVTIDGFSGNIWAITPPSYQALLMKLRSPESDLLLHFHMKCRRSTKEIQSSHTSVEDIFSRKLSPSEKLQLLMVLNSTNFTFPISDSNRNSLYRTSIMNNNNNSNSMLTRSYQSQIDSVTLNSVLPRYVLLKKDKLRGAYAFLGDP-QTYVNVSFHIHQDLISHQTWWELKEKINSSPSSDPCFEVIRHPTLSNNAVEANVLSVLTFNERVSDSLFGKVFNNYGIIGMYAAYIFLASRLLRTAYSNISYVIRLEELPHVDRILNLCHEIYLVRENNLLLLEEQLVAKLFFLYRSSETMIKWTRHPKHIVE 3214
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2-like [Source:NCBI gene;Acc:103047759]) HSP 1 Score: 432.18 bits (1110), Expect = 1.557e-125 Identity = 227/593 (38.28%), Postives = 366/593 (61.72%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSL---HQNQNNTYLNISLSMK-TDNA----MMWWEVNEIIQGQ-SYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
+R+F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P F+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T+++F+ + QL YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IFVLKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S + + V P++ S +I +G + P+F S+++N ++ +T+ F + + + + +L+++ +D T+ ++ S+++W I+PP K L E LS + M +R + E + +L + L++L+N N V + +FP F+ R S++N+ H +N Y +I+L +K +DN+ WW V++ G + K+ L +++F++++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELP VDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2240 IRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNMVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKDVTEAEFLKFMNSYNYIPGAMQFLEAYTAEDVTEAELEGNSNSLWTISPPSRKSLMEVLS-KEDQFPVTMSWTIQRNLSLGAKAE-VAMDKHVTYLDTNTRQELINLLNGTRNKA-VIIKEVFPCFI----RAPSDSNAKPIDHLYGDNGYKDITLDLKRSDNSSGEIQEWWIVDQPSAGMIDMKSGVKTEQKREAGLRLYVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2823 HSP 2 Score: 117.087 bits (292), Expect = 8.504e-26 Identity = 74/151 (49.01%), Postives = 99/151 (65.56%), Query Frame = 3
Query: 1224 EEYLKEQEXXXXXXXXXL-LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTN-DRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRD 1670
+E L+E E S L L +L N+ + +SE VCY ++ILNHM+S ++ +L P+++FLWAMLSVPRPSK FW+ I YTE+ IVIKY FQF F FN+ D+ P P IIG+EK + Y DL+QLL +F HR LK +GLW +
Sbjct: 1958 DEELEESERFYSSQPQILQLCYALYNMLVAHSEMVCYLVIILNHMISASVATLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQNIELDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCHGLWDE 2108
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2-like [Source:NCBI gene;Acc:103047759]) HSP 1 Score: 429.098 bits (1102), Expect = 1.672e-124 Identity = 229/594 (38.55%), Postives = 367/594 (61.78%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLP--SKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSL---HQNQNNTYLNISLSMK-TDNA----MMWWEVNEIIQGQ-SYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
+R+F+ + +P+++ DVYV MFL + + F+II+FG+ +FG + +AD + +++P F+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T+++F+ + QL YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IFVLKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S + + V P++ S +I +G + P+F S+++N ++ +T+ F + C+ P + +L+++ +D T+ ++ S+++W I+PP K L E LS + M +R + E + +L + L++L+N N V + +FP F+ R S++N+ H +N Y +I+L +K +DN+ WW V++ G + K+ L +++F++++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELP VDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+
Sbjct: 2093 IRQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSS-LSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNMVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKDVTEAEFLNLM-CNICFFPQGAMQFLEAYTAEDVTEAELEGNSNSLWTISPPSRKSLMEVLS-KEDQFPVTMSWTIQRNLSLGAKAE-VAMDKHVTYLDTNTRQELINLLNGTRNKA-VIIKEVFPCFI----RAPSDSNAKPIDHLYGDNGYKDITLDLKRSDNSSGEIQEWWIVDQPSAGMIDMKSGVKTEQKREAGLRLYVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTR 2676 HSP 2 Score: 116.701 bits (291), Expect = 1.082e-25 Identity = 74/151 (49.01%), Postives = 99/151 (65.56%), Query Frame = 3
Query: 1224 EEYLKEQEXXXXXXXXXL-LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTN-DRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRD 1670
+E L+E E S L L +L N+ + +SE VCY ++ILNHM+S ++ +L P+++FLWAMLSVPRPSK FW+ I YTE+ IVIKY FQF F FN+ D+ P P IIG+EK + Y DL+QLL +F HR LK +GLW +
Sbjct: 1805 DEELEESERFYSSQPQILQLCYALYNMLVAHSEMVCYLVIILNHMISASVATLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFNQNIELDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCHGLWDE 1955
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 426.402 bits (1095), Expect = 1.310e-123 Identity = 231/596 (38.76%), Postives = 367/596 (61.58%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCER-----PSTDSKSTEKIVRFTQSRFLTNPEKANLLHLIN-TKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNE----IIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWK 3551
+R+F+ + +P ++ DVYV MFL + + F+II+FG+ +FG AD + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP +T+++F+ QL YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ ++PFL ELR VMDW+WTD++++ W+ VEDI++ IFVLKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S + + V P++ S S+ +G + P+F S+++ N+ +T F+ + + + +L+++ D T ++ +S+++W I+PP K L L+ + + M +R ++ + +KI+ + T + A LL N T + V + +IFPR+L R S++N+ Q +T +++ L+ D+ WW VN+ +++ +S N DSP L ++IF++++S G + + YGI+G+Y + V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE L AKLIFLYRS ETMIKWT+ K
Sbjct: 2109 IRQFFYNLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHQGGADITSS-LSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVVLVFGIHFWMFFILPGVTERRFSQNRIAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLIPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNTPLDVSVSLTLGGFQPIFTMSAQQKNLNSITSAKFDNFVKHFSKNSFAVQFLEAYVYQDLTVAHLEGSSNSMWTISPPSKKNLIGMLNQADSDFPLTMTWSIQRNLSLGAKSEMATGKKIINLDKE---TKIQLAKLLIETNSTDAHKKPVCIKSIFPRYL----RAPSDSNAKLIEQLSTDIDLFLNRAEDSNKEWWVVNQTKFGLLKLESVKIN-DSPR-----LELYIFSDQVSPPSLGFL-AGYGIMGLYMSVVLVIGKFVREFFSGISHTIMFEELPNVDRILKLCTDIFLVRETGELDLEEDLYAKLIFLYRSPETMIKWTREKK 2689 HSP 2 Score: 116.316 bits (290), Expect = 1.768e-25 Identity = 69/131 (52.67%), Postives = 90/131 (68.70%), Query Frame = 3
Query: 1278 LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRD 1670
L +L N+ + +SE V Y ++ILNHM+S ++ +L P+++FLWAMLSVPRPSK FW+ I YTE+ IVIKY FQF+F FN+ DR P P IIG+EK Y DLIQLL +F HR LK +GLW +
Sbjct: 1837 LCYALYNLLVAHSEMVSYLVIILNHMISASMVTLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFSFFPFNQNMIDRNKPYHPPNIIGVEKKDGYVHYDLIQLLTLFFHRSILKCHGLWDE 1967
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:ZFIN;Acc:ZDB-GENE-041111-255]) HSP 1 Score: 382.874 bits (982), Expect = 2.900e-109 Identity = 220/589 (37.35%), Postives = 354/589 (60.10%), Query Frame = 3
Query: 1803 RFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIV-RFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSE-ANSLHQNQNNTYLNISLSMKTD------NAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
RF+ + + ++ DVY MFL + + F+II+FG+ +FG + +AD A + +++P F+ M++ QF ++IDRAL+LRK V GK IFQI V IH W+FF LP +T++ FN QL YFVKCIYF LSAYQ++ GYP RILGNFLT+ +N++NLFLF+G+ +VPFL ELR VMDW+WTD++++ +WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI+ F IW PL+ S + + V P++ + ++ +G Y PLF S ++ +++P T+ + + E + + ++ + +D I+ +S +VW I+PP +++ ++L A + + + +R + E + + + NP +A+L L+ + V +P +FP ++ A ++ + L++ Y N++LS+ D A WW+++ + D S L + IFN+++S G + + YGI+G+Y + V+ +F+R F+S IS+ I EELP VDRI KL +I+LVRE +L LEE+L +KLIFLYRS ETMIKWT+
Sbjct: 1900 RFFHNILHAEYRAATDVYALMFLTDVVDFIIIVFGFWAFGKHSAAADIA-STLSEDQVPEAFLVMLLIQFSTMVIDRALYLRKAVLGKLIFQIILVFGIHLWMFFILPAVTERMFNQNFVAQLWYFVKCIYFTLSAYQVRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIVFFLICIIWFPLLFISLVRSVVGVVNHPVDVTVTVKLGGYEPLFTMSVQQQSIQPFTEADYNHLTELFGSNAVAMQFITLYSYEDIVTANIEGSSGSVWRISPPSRQEVIKELLGSPADMTLRLAWNFQRDLNKGGTVENTFDKHSINLEPGNPVRADLASLLVGN-RTEPVRVPHMFPNYIRAPNGAEAKPVSQLYEGDEEGYQNVTLSLMRDGSLNGSGAQEWWDIS--------VADCDQSSGACGVLPMIIFNDKVSPPSLGFL-AGYGIMGLYVSVVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEELYSKLIFLYRSPETMIKWTR 2477 HSP 2 Score: 121.709 bits (304), Expect = 3.469e-27 Identity = 63/135 (46.67%), Postives = 94/135 (69.63%), Query Frame = 3
Query: 1278 LAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVD---PLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDH 1673
L +L NV +SE CYF+++LN+ ++ ++ SL P+++FLWAML+VPRPSK+FW+ I YTE+++V+KY+FQF F +N R++ P + P I+G+EK+ NY DL+QLL +F HR L+ GLW DH
Sbjct: 1609 LLFALYNVLACHSELACYFIIVLNNAVTASVISLVLPILIFLWAMLAVPRPSKSFWMTAIVYTEVMVVVKYLFQFGFFPWNSEYETRLNENKPFFPPRILGLEKTDNYIRYDLLQLLALFFHRSLLQRYGLW-DH 1742
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:ZFIN;Acc:ZDB-GENE-041111-255]) HSP 1 Score: 68.9366 bits (167), Expect = 1.557e-11 Identity = 67/283 (23.67%), Postives = 130/283 (45.94%), Query Frame = 3
Query: 2493 YSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKK-LKEKLSIPRASLKINMQAVCERPSTDSKSTEKIV-RFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTD------NAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILG 3314
Y +G LI+ F IW PL+ S + + V P++ + ++ +G Y PLF S ++ +++P T+ + + E + + ++ + +D I+ +S +VW I+PP ++ +KE L P A + + + +R + E + + + NP +A+L L+ N T+ +P +FP ++ A +EA + Q Y N++LS+ D A WW+++ + D S L + IFN++ + FS + + G
Sbjct: 44 YGMGGLIVFFLICIIWFPLLFISLVRSVVGVVNHPVDVTVTVKLGGYEPLFTMSVQQQSIQPFTEADYNHLTELFGSNAVAMQFITLYSYEDIVTANIEGSSGSVWRISPPSRQEVIKELLGSP-ADMTLRLAWNFQRDLNKGGTVENTFDKHSINLEPGNPVRADLASLL--VGNRTD-RVPHMFPNYIRAPNG--AEAKPVSQLYEEGYQNVTLSLMRDGSLNGSGAQEWWDIS--------VADCDQSSGACGVLPMIIFNDKDHGAVRIRDFSLHHVRG 312
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009619.1 (pep scaffold:Pmarinus_7.0:GL484020:1370:4517:1 gene:ENSPMAG00000008693.1 transcript:ENSPMAT00000009619.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 122.479 bits (306), Expect = 6.390e-32 Identity = 61/129 (47.29%), Postives = 85/129 (65.89%), Query Frame = 3
Query: 3159 WWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
WW + ++ D P ++ + I +F++R+S G + + YGILG+YA+ VV +F+R F+S IS+ I EELPNVDR+ KL +I+LVRE +L+LEE L AKLIFLYRS ETMIKWT+
Sbjct: 75 WWSLRQL--------RSDCPGRRCDDIRIIVFSDRVSPPSLGFL-AGYGILGLYASVVLVVGKFVREFFSGISHSIMFEELPNVDRVLKLCTDIFLVRETGELQLEEDLYAKLIFLYRSPETMIKWTRE 194
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO30292 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T173]) HSP 1 Score: 208.764 bits (530), Expect = 2.529e-57 Identity = 111/319 (34.80%), Postives = 182/319 (57.05%), Query Frame = 3
Query: 1959 IKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHK-----------------FHLPSKDYLQSFEPD--DATQII---IDYASDNVWLITPPGLKKLKEKL 2849
++ N +P F+ M+++QF IIIDR L+LRK V K F +F + H ++F +P++TK+ F I +Y C+YF LSAYQ++SGYP RILGNFLT+ + + LF+G+ +PFL ELR+V+DW+ TD+++ YHW+++EDI++ I+VLKC+R E W RG+ ++ K+++G L++ IW PL+ S+I + PP + +F++++G Y PLF S++E + L + +K H F+ K + +F D D ++ I S ++W I+PP + + L
Sbjct: 161 VEENVVPKTFLYMLLSQFFLIIIDRCLYLRKYVFAKLFFLLFLTVSFHVFMFIVVPYVTKRPFFKNIPAIFMYIFMCMYFGLSAYQVRSGYPTRILGNFLTKSYTLTSGVLFQGFQAIPFLLELRSVLDWVCTDTTLTLYHWLKMEDIYANIYVLKCYRESEKTWFQGRGQKYWMLSKWTVGGLLVALLVIVIWFPLLFMSYINSVYTSNPPQDATFTLSIGGYQPLFRVSAQEQFLERLNNTKIDRIKTQHPGLHQGADTQPPLQVAIIFNCVLKIQIDTFLADYHDRGTVVLVKITGNSSSIWQISPPSRQLMMHDL 479 HSP 2 Score: 92.8189 bits (229), Expect = 2.884e-19 Identity = 41/80 (51.25%), Postives = 64/80 (80.00%), Query Frame = 3
Query: 3306 ILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQH 3545
I+G+Y + ++V +F+R F+++ISY I +E+PNVD++ KL +I++VRE+K +LEE L AKL+FLYRS ET+IKWT++
Sbjct: 496 IIGLYVGFVWLVGKFVRLFFTSISYRIMFDEMPNVDKVLKLCLDIFMVRESKSFKLEEDLFAKLMFLYRSPETLIKWTKY 575
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO47370 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM3]) HSP 1 Score: 160.614 bits (405), Expect = 1.334e-40 Identity = 125/404 (30.94%), Postives = 202/404 (50.00%), Query Frame = 3
Query: 954 PESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNE---KRLVKLKVLSKISNEVDGRIELEAIVVEIVGD-------GSHSFVNSKNQEEY----LKEQEXXXXXXXXXLLAISLGNVAIIYS-----EFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTN----DRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKE-------------QDGRNKIKSS-----YEESSPTSNKWSCNPIYK-MRRFYSKMTNPKFNK-KVDVYVFMFLCEFIAFLIIIFGYVSF-GPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDR 2033
PE ++ K +YY+ D +I +++ +K+YR I L +E KRL KL+ + + R + V D GS + + ++ + + + + S + + ++ +VA +Y+ + +CY L+ILNHM+ L S+P P +VF+W MLS+PRP+K +WI +ITYT+IVIVIKY+F+F F N + D+ DPL IIGIE+ + + DL+ LL ++ HR LK +GLWRD E+ + RN SS Y+ S + N I + ++ F +++ +P+ VDVY MF C+FI F+II+F + +F P ++ N +P F+ M+++QF IIIDR
Sbjct: 105 PEGLVTRLKKLFSWIYYYFAIAIDKVIDVLSDISKDYREIADQLKHERKEKRLEKLRRGRYSYSSLRARTLAASASAAEVSDSDVIENKGSATSRSDEDADSWSVLNIDLDDTDASNWKHSHMRVARFSVAFVYALLAHTDIICYLLMILNHMVYACLLSMPLPFLVFMWGMLSIPRPTKRYWITVITYTQIVIVIKYLFKFQFKFINNCNSSDGPDKNDPLCPARIIGIERDSHTSAYDLLLLLALYFHRYSLKVHGLWRDKAAHDDHDELYEPPLSPNSPKSEPTPFAGSRNMAASSPDSEQYQSDVEDSGESLWNKICRSVKAFLNRIYDPEVGSGAVDVYAIMFACQFIIFIIILFSWSAFSSPEPQRQAQFVKIVEENVVPKTFLYMLLSQFFLIIIDR 508 HSP 2 Score: 112.079 bits (279), Expect = 3.624e-25 Identity = 50/144 (34.72%), Postives = 88/144 (61.11%), Query Frame = 3
Query: 2283 LFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECH 2714
L + + +PFL ELR+V+DW+ TD+++ YHW+++EDI++ I+VLKC+R E W RG+ ++ K+++G L++ IW PL+ S+I + PP + +F++++G Y PLF S++E + L + +K H
Sbjct: 503 LIIIDRFQAIPFLLELRSVLDWVCTDTTLTLYHWLKMEDIYANIYVLKCYRESEKTWFQGRGQKYWMLSKWTVGGLLVALLVIVIWFPLLFMSYINSVYTSNPPQDATFTLSIGGYQPLFRVSAQEQFLERLNNTKIDRIKTQH 646
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO47369 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM2]) HSP 1 Score: 93.5893 bits (231), Expect = 5.260e-23 Identity = 41/83 (49.40%), Postives = 66/83 (79.52%), Query Frame = 3
Query: 3306 ILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKS 3554
I+G+Y + ++V +F+R F+++ISY I +E+PNVD++ KL +I++VRE+K +LEE L AKL+FLYRS ET+IKWT++ ++
Sbjct: 1 IIGLYVGFVWLVGKFVRLFFTSISYRIMFDEMPNVDKVLKLCLDIFMVRESKSFKLEEDLFAKLMFLYRSPETLIKWTKYKRA 83
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: piezo1 (piezo type mechanosensitive ion channel component 1 [Source:NCBI gene;Acc:101175341]) HSP 1 Score: 457.603 bits (1176), Expect = 2.592e-134 Identity = 288/790 (36.46%), Postives = 457/790 (57.85%), Query Frame = 3
Query: 1311 YSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFN---ETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGL-------------------WRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKM------------RRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANS-----LHQNQNNTYLNISLSMKTD------NAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
+SE +CY +++LN+++S ++ S+ P++VFLWAML++PRPSK FW+ I YTE+++V+KYIFQF F S+N E T ++ P + P I+G+EK+ NY DL+QLL +F HR L L + +++ + KE++ ++++ E+ ++ + K+ + F+ + + K DVY MFL + + F+IIIFG+ +FG + +AD A + +++P F+ M++ F +IIDRAL+LRK V GK IFQ VL IH W+FF LP +T++KFN QL YFVKCIYF LSAYQ++ GYP RILGNFLT++F ++NLFLF+G+ +VPFL ELR VMDW+WTD++++ +WM VEDI++ IF++KC R E +P +G+ ++ +VKY +G LI+ F IW PL+ S + + V PI+ + ++ +G Y PLF S ++ +++P +EE+ + K + + ++ + +D I+ +S +VW I+PP +++ ++L + L + + +R + E T ++ + E NL+ N P + P F Y R + A + L++ + YL I+LS+K+D WW++ ++G C P L + IFN+++S G + + YGI+G+Y + V+ +F+R F+S IS+ I EELP VDRI KL +I+LVRE +L LEE+L +KLIFLYRS ETMIKWT+
Sbjct: 1494 HSELLCYLIIVLNNVVSASVISVVLPILVFLWAMLALPRPSKRFWMTAIVYTEVMVVLKYIFQFGFFSWNSAHEMTVNKDRPFFPPRILGLEKTDNYLRYDLLQLLALFFHRALLMVCTLNLKSFRPDQEALLAKAAALRKKEALVPEEIHLRAKEEEEEMRLRAKKEQLELETDLTVASARLKVYESLKDVQSSPAQNFFKNLMHNKHQASTDVYALMFLTDMVDFVIIIFGFWAFGKHSAAADIA-STLSEDQVPEAFLVMLLIHFSTMIIDRALYLRKAVLGKLIFQGILVLGIHVWMFFILPSVTERKFNQNFVAQLWYFVKCIYFGLSAYQIRCGYPTRILGNFLTKNFGHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIVFFLICIIWFPLLFISLVRSVVGVVNHPIDVTVTVKLGGYEPLFTMSVQQQSIQPFNNSQYEELTKMFKDN-TAMQFITLYSYEDIVTAQIEGSSGSVWRISPPSRQEVIKELLGSQVDLTLRLAWNFQRDLGKGGTVEH----TFDKYSIDLEPGNLVRAELASLLIGNRTEPVLVPNFFPNYIRAPNGAEAKPVSQLYKGGEDGYLGITLSLKSDRSSNSSGTREWWDIA--VEG---CVPPSCG-----VLRMVIFNDKVSPPSLGFL-AGYGIMGLYVSVVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEELYSKLIFLYRSPETMIKWTR 2266
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:101174622]) HSP 1 Score: 404.445 bits (1038), Expect = 1.992e-116 Identity = 225/595 (37.82%), Postives = 348/595 (58.49%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKL------KEKLSIPRA-SLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMK-----TDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
M++F+ + +P+++ DVYV MFL + + F+II+FG+ +FG S + + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP IT+K+FN Q+ YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD+S++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S + + V P++ S +I + + P+F S+++ + +TK + +L+++ P+D + +S+++W I+PP L +E+ SI + S++ N+ E S K+ L K NL+ L+N ++ N + FLT N ++I L+M+ + A WW VN+ Q P K L I++F++++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE + +KLIFLYRS ETMIKWT+
Sbjct: 2053 MKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFG--KHSTADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVLLVFGIHFWMFFILPIITEKRFNENTVAQMWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTSLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVVLLICIVWFPLLFMSLVKSVAGVVNAPLDVSVTITLAGFQPIFTMSAQQKQLWNVTKTAIQ--------------WLENYTPEDLIIAELKGSSNSLWTISPPSRDNLIDMLRSQEEFSITVSWSIQRNLSLGAEAESAYGKNV---------MVLNQETKQNLILLLNGAADAANTQVI-----FLTG----------------NKMIDIHLTMQRAQNDSGQAQEWWIVNQTEQSII----PKIGRKHEAGLEIYVFSDQVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHKIMFEELPNVDRILKLCTDIFLVRETGELDLEEDMYSKLIFLYRSPETMIKWTR 2596 HSP 2 Score: 116.316 bits (290), Expect = 1.656e-25 Identity = 72/168 (42.86%), Postives = 101/168 (60.12%), Query Frame = 3
Query: 1287 SLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRV---DPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW-----RDHTEFAQD---------LEIVDKEQDGRNKIKS 1739
+L N+ + +SEFVCY ++I+NHM+S + SL P+ +FLWAMLSVPRPSK +W+ I YTE+ IVIKY QF F F + N R+ P + IIG+EK Y + DL+QLL +F HR LK +GLW ++ E A+ + +KE+ N +KS
Sbjct: 1793 ALYNMLVAHSEFVCYLVIIINHMVSASCVSLVLPVTIFLWAMLSVPRPSKRYWMTAIVYTEVTIVIKYFCQFGF--FPHSKNYRLYKNAPYYPANIIGVEKKDGYVLYDLVQLLALFFHRSILKCHGLWDEDDPKERKEAARQSESEYEEKEKSVREKERSSTNTMKS 1958
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:101174622]) HSP 1 Score: 399.823 bits (1026), Expect = 7.570e-115 Identity = 227/604 (37.58%), Postives = 355/604 (58.77%), Query Frame = 3
Query: 1797 MRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCER-PSTDSKST--EKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVY-------------LPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMK-----TDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQ 3542
M++F+ + +P+++ DVYV MFL + + F+II+FG+ +FG S + + +++P PF+ M++ QF +++DRAL+LRK V GK IFQ+ V IH W+FF LP IT+K+FN Q+ YFVKCIYF LSAYQ++ GYP R+LGNFLT+ +NY+NLFLF+G+ +VPFL ELR VMDW+WTD+S++ W+ VEDI++ IF+LKCWR E +P RG+ ++ VVKY +G +I++ +W PL+ S + + V P++ S +I + + P+F S+++ + +TK + +L+++ P+D + +S+++W I+PP L + L + I + +R P+ DS + I+ T L + ++ L +F Y L + PR++ A + S+A S+ Q N ++I L+M+ + A WW VN+ Q P K L I++F++++S G + + YGI+G+YA+ V+ +F+R F+S IS+ I EELPNVDRI KL +I+LVRE +L LEE + +KLIFLYRS ETMIKWT+
Sbjct: 2167 MKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGK--HSTADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVLLVFGIHFWMFFILPIITEKRFNENTVAQMWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTSLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVVLLICIVWFPLLFMSLVKSVAGVVNAPLDVSVTITLAGFQPIFTMSAQQKQLWNVTKTAIQ--------------WLENYTPEDLIIAELKGSSNSLWTISPPSRDNLIDMLR-SQEEFSITVSWSIQRYPNIDSPLMMFDHIIPHTLQLCLKKKKLFYVILLNIFQFLFVIFYFIFFKQNLFRKKTLTKLIPRYIRAPSK--SDATSVEQ-LGNKMIDIHLTMQRAQNDSGQAQEWWIVNQTEQS----IIPKIGRKHEAGLEIYVFSDQVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHKIMFEELPNVDRILKLCTDIFLVRETGELDLEEDMYSKLIFLYRSPETMIKWTR 2745 HSP 2 Score: 118.627 bits (296), Expect = 2.779e-26 Identity = 74/166 (44.58%), Postives = 102/166 (61.45%), Query Frame = 3
Query: 1287 SLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRV---DPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLW-RDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNK 1772
+L N+ + +SEFVCY ++I+NHM+S + SL P+ +FLWAMLSVPRPSK +W+ I YTE+ IVIKY QF F F + N R+ P + IIG+EK Y + DL+QLL +F HR LK +GLW D + ++ + +KE E SSP S+K
Sbjct: 1904 ALYNMLVAHSEFVCYLVIIINHMVSASCVSLVLPVTIFLWAMLSVPRPSKRYWMTAIVYTEVTIVIKYFCQFGF--FPHSKNYRLYKNAPYYPANIIGVEKKDGYVLYDLVQLLALFFHRSILKCHGLWDEDDPKERKEASVREKES----------EPSSPLSHK 2057
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: ENSORLT00000004626.2 (pep primary_assembly:ASM223467v1:7:7477416:7483305:1 gene:ENSORLG00000003710.2 transcript:ENSORLT00000004626.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 368.622 bits (945), Expect = 2.139e-113 Identity = 220/618 (35.60%), Postives = 338/618 (54.69%), Query Frame = 3
Query: 1722 RNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSK-DYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPR---ASLKINMQAVCERPS--TDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKS 3554
R +IK ++ + S + +R+F+ + +P+++ DVY MFL + + F++ I+GY +FG + AD + + +++P F+ M++ QF +I+DRAL+L+K + GK +FQ+ V IH W+FF LP +T+++FN QL YFVKCIYF LSAYQ+K GYP RILGNFLT+++NY+NLFLF+G+ +VPFL ELR VMDW+WTD++++ W+ VEDI++ IFVLKCWR E +P G+ ++ VVKY +G I+ IW PL+ S + V P+E S +++ Y PLF S++E N+ F L S +L ++E +D I + +W I+P + E+LSI AS+ +N++AV E D + IV + ++ +L L F R ++ + S A+ +Q WW V E P S K + I +FN+++S + G + + +GI+G+Y + V+ +F+R F++ IS I EELP VDR+ KL +I++VRE ++ LEE L KLIFLYRS ETMIK T+ S
Sbjct: 1 RQQIKERMLQAKAAIIEVSLHIYLPIRQFFYDIIHPEYSPVCDVYALMFLIDVVNFIVTIYGYWAFGKYSAVADIT-ESLSEDQVPEAFLVMLLMQFGTMIVDRALYLKKSLLGKCVFQVVLVFGIHFWMFFILPGVTERRFNRNPIAQLWYFVKCIYFGLSAYQIKCGYPNRILGNFLTKNYNYLNLFLFQGFRMVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYANIFVLKCWRESEKKYPHPPGQKKKKVVKYGMGGFIIFALISIIWFPLLFMSLVQSAAGVTNQPVEVSIQLSIAGYEPLFTMSAQEQNLV------------ASLFLLQSAMQFLMNYEAEDIIVAKIKSDASLLWSISPASRAAMIEELSISSHLNASISMNVEAVGEHTVKFNDKALKDGIVSMLKGNSSKPSDRPDLQAL--------------AFFRPMSIKLQQASGASDKEADQ------------------WWVVEEC------SPVLTSSEPKCHSIEIVVFNDKVSPSSLGFL-AGHGIVGLYMSVVLVIGKFVREFFNGISRSIMFEELPCVDRVLKLCTDIFVVRETGEMELEETLFEKLIFLYRSPETMIKMTREKDS 566
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: piezo1 (piezo type mechanosensitive ion channel component 1 [Source:NCBI gene;Acc:101175341]) HSP 1 Score: 71.633 bits (174), Expect = 1.350e-12 Identity = 63/269 (23.42%), Postives = 122/269 (45.35%), Query Frame = 3
Query: 2493 YSLGXXXXXXXXXXXWGPLMISSFI-GITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANS-----LHQNQNNTYLNISLSMKTDNA------MMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNER 3263
Y +G LI+ F IW PL+ S + + V PI+ + ++ +G Y PLF S ++ +++P +EE+ + K + + ++ + +D I+ +S +VW I+PP +++ ++L + L + + +R + E T ++ + E NL+ N P + P F Y R + A + L++ + YL I+LS+K+D + WW++ ++G C P L + IFN++
Sbjct: 41 YGMGGLIVFFLICIIWFPLLFISLVRSVVGVVNHPIDVTVTVKLGGYEPLFTMSVQQQSIQPFNNSQYEELTKMFKDNATAMQFITLYSYEDIVTAQIEGSSGSVWRISPPSRQEVIKELLGSQVDLTLRLAWNFQRDLGKGGTVEH----TFDKYSIDLEPGNLVRAELASLLIGNRTEPVLVPNFFPNYIRAPNGAEAKPVSQLYKGGEDGYLGITLSLKSDRSSNSSGTREWWDI--AVEG---CVPPSCG-----VLRMVIFNDK 295
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000051188.1 (SMESG000051188.1) HSP 1 Score: 1875.52 bits (4857), Expect = 0.000e+0 Identity = 1003/1159 (86.54%), Postives = 1059/1159 (91.37%), Query Frame = 3
Query: 129 VVRSGDKYLFXXXXXXXXXXXXXXXXXXCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLXXXXXXXXXXXXXXXXXXXXXXXXXXNPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSEHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLSLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKPAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLEANQVERVSADDADN 3605
VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSEHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQL+LDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEK AHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSH+FVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTD+SVA +HWMEVED+F KIFVLKCWR E +PT RG RRL KYS+G L+L FFF C WGPL +SSFIG TFVK PPIEC+FSI+VG YSPLF F SRENN++ L K TF++MKEC+K P DYL SFE D TQI ID +SD+VW ITPP L+KLK KL SLKINMQA+CER S+DSK+TEK+VR T ++ L +K NLL I +S V + IFPRFLTAYKRTLSEA +L ++ N TYLN++LSMK +N WWE+ EI+ G++YC N P + + LT+FIF+ER+SDN+FGH+FS+YGI+G+YAAY FV HR LR FYS+ISYII EELP+VDRI LL+EIYLVRENK RLEEQLIAKLIFLYRS+ETMIKWT+H KS L N +E+ +D DN
Sbjct: 1419 VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSEHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLTLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKSAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHNFVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLR-STESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKN-MEKTKSDAIDN 2575
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000051188.1 (SMESG000051188.1) HSP 1 Score: 1867.43 bits (4836), Expect = 0.000e+0 Identity = 1003/1174 (85.43%), Postives = 1059/1174 (90.20%), Query Frame = 3
Query: 129 VVRSGDKYLFXXXXXXXXXXXXXXXXXXCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLXXXXXXXXXXXXXXXXXXXXXXXXXXNPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMS---------------EHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLSLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKPAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLEANQVERVSADDADN 3605
VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMS EHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQL+LDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEK AHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSH+FVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTD+SVA +HWMEVED+F KIFVLKCWR E +PT RG RRL KYS+G L+L FFF C WGPL +SSFIG TFVK PPIEC+FSI+VG YSPLF F SRENN++ L K TF++MKEC+K P DYL SFE D TQI ID +SD+VW ITPP L+KLK KL SLKINMQA+CER S+DSK+TEK+VR T ++ L +K NLL I +S V + IFPRFLTAYKRTLSEA +L ++ N TYLN++LSMK +N WWE+ EI+ G++YC N P + + LT+FIF+ER+SDN+FGH+FS+YGI+G+YAAY FV HR LR FYS+ISYII EELP+VDRI LL+EIYLVRENK RLEEQLIAKLIFLYRS+ETMIKWT+H KS L N +E+ +D DN
Sbjct: 1423 VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSSVGLDIHGSRQTRRSEHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLTLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKSAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHNFVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLR-STESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKN-MEKTKSDAIDN 2594
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000051188.1 (SMESG000051188.1) HSP 1 Score: 1865.51 bits (4831), Expect = 0.000e+0 Identity = 1003/1174 (85.43%), Postives = 1059/1174 (90.20%), Query Frame = 3
Query: 129 VVRSGDKYLFXXXXXXXXXXXXXXXXXXCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLXXXXXXXXXXXXXXXXXXXXXXXXXXNPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMS---------------EHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLSLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKPAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLEANQVERVSADDADN 3605
VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMS EHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQL+LDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEK AHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSH+FVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTD+SVA +HWMEVED+F KIFVLKCWR E +PT RG RRL KYS+G L+L FFF C WGPL +SSFIG TFVK PPIEC+FSI+VG YSPLF F SRENN++ L K TF++MKEC+K P DYL SFE D TQI ID +SD+VW ITPP L+KLK KL SLKINMQA+CER S+DSK+TEK+VR T ++ L +K NLL I +S V + IFPRFLTAYKRTLSEA +L ++ N TYLN++LSMK +N WWE+ EI+ G++YC N P + + LT+FIF+ER+SDN+FGH+FS+YGI+G+YAAY FV HR LR FYS+ISYII EELP+VDRI LL+EIYLVRENK RLEEQLIAKLIFLYRS+ETMIKWT+H KS L N +E+ +D DN
Sbjct: 1418 VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSSVGLDIHGSRQTRRSEHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLTLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKSAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHNFVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLR-STESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKN-MEKTKSDAIDN 2589
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000051188.1 (SMESG000051188.1) HSP 1 Score: 1864.35 bits (4828), Expect = 0.000e+0 Identity = 1003/1174 (85.43%), Postives = 1059/1174 (90.20%), Query Frame = 3
Query: 129 VVRSGDKYLFXXXXXXXXXXXXXXXXXXCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLXXXXXXXXXXXXXXXXXXXXXXXXXXNPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMS---------------EHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLSLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKPAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLEANQVERVSADDADN 3605
VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMS EHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQL+LDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEK AHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSH+FVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTD+SVA +HWMEVED+F KIFVLKCWR E +PT RG RRL KYS+G L+L FFF C WGPL +SSFIG TFVK PPIEC+FSI+VG YSPLF F SRENN++ L K TF++MKEC+K P DYL SFE D TQI ID +SD+VW ITPP L+KLK KL SLKINMQA+CER S+DSK+TEK+VR T ++ L +K NLL I +S V + IFPRFLTAYKRTLSEA +L ++ N TYLN++LSMK +N WWE+ EI+ G++YC N P + + LT+FIF+ER+SDN+FGH+FS+YGI+G+YAAY FV HR LR FYS+ISYII EELP+VDRI LL+EIYLVRENK RLEEQLIAKLIFLYRS+ETMIKWT+H KS L N +E+ +D DN
Sbjct: 1402 VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSSVGLDIHGSRQTRRSEHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLTLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKSAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHNFVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLR-STESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKN-MEKTKSDAIDN 2573
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000051188.1 (SMESG000051188.1) HSP 1 Score: 1858.57 bits (4813), Expect = 0.000e+0 Identity = 1003/1197 (83.79%), Postives = 1059/1197 (88.47%), Query Frame = 3
Query: 129 VVRSGDKYLFXXXXXXXXXXXXXXXXXXCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLXXXXXXXXXXXXXXXXXXXXXXXXXXNPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMS--------------------------------------EHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLSLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKPAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHSFVNSKNQEEYLKEQEXXXXXXXXXLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAXXXXXXXXXXXXHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGXXXXXXXXXXXWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLEANQVERVSADDADN 3605
VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMS EHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQL+LDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEK AHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSH+FVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTD+SVA +HWMEVED+F KIFVLKCWR E +PT RG RRL KYS+G L+L FFF C WGPL +SSFIG TFVK PPIEC+FSI+VG YSPLF F SRENN++ L K TF++MKEC+K P DYL SFE D TQI ID +SD+VW ITPP L+KLK KL SLKINMQA+CER S+DSK+TEK+VR T ++ L +K NLL I +S V + IFPRFLTAYKRTLSEA +L ++ N TYLN++LSMK +N WWE+ EI+ G++YC N P + + LT+FIF+ER+SDN+FGH+FS+YGI+G+YAAY FV HR LR FYS+ISYII EELP+VDRI LL+EIYLVRENK RLEEQLIAKLIFLYRS+ETMIKWT+H KS L N +E+ +D DN
Sbjct: 1419 VVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSSVGLDIHGSRQTRRKTIHQPYSCQTLRRSNAVVIEDASEHDELSSLPDAYNTPPPAHISETTTEDSFHSAAIQDNQLTNDQAQLTLDLYSANTPESEKYLNPLIYRDTNISSNSVPELISNDETDKKIEKSAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHNFVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFNETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLR-STESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKN-MEKTKSDAIDN 2613 The following BLAST results are available for this feature:
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30008757 ID=SMED30008757|Name=Piezo-type mechanosensitive ion channel component|organism=Schmidtea mediterranea sexual|type=transcript|length=3999bpback to top protein sequence of SMED30008757-orf-1 >SMED30008757-orf-1 ID=SMED30008757-orf-1|Name=SMED30008757-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1154bp MTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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