Homeobox domain-containing protein

Overview


Name	Homeobox domain-containing protein
Smed ID	SMED30008752
Length (bp)	1837

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Homeobox domain-containing protein (SMED30008752) t-SNE clustered cells

Violin plots show distribution of expression levels for Homeobox domain-containing protein (SMED30008752) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Homeobox domain-containing protein (SMED30008752) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Homeobox domain-containing protein (SMED30008752) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30008752

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X2 cell	SMED30008752	SMESG000016670.1	SmedASXL_006490	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30008752	SMESG000016670.1	dd_Smed_v4_11150_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30008752	SMESG000016670.1	dd_Smed_v4_11150_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neuron	SMED30008752	SMESG000016670.1	dd_Smed_v4_11150_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parapharyngeal region	SMED30008752	SMESG000016670.1	dd_Smed_v4_11150_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30008752	SMESG000016670.1	dd_Smed_v4_11150_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30008752	SMESG000016670.1	dd_Smed_v4_11150_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30008752	SMESG000016670.1	dd_Smed_v4_11150_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30008752	SMESG000016670.1	dd_Smed_v6_11150_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: ALX3 (ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449])

HSP 1 Score: 90.5077 bits (223), Expect = 3.541e-20
Identity = 42/71 (59.15%), Postives = 51/71 (71.83%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDG 675
            K KK R+RTTFS +QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I +G
Sbjct:    7 KSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEG 77

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BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: ALX3 (ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449])

HSP 1 Score: 93.2041 bits (230), Expect = 5.314e-20
Identity = 44/79 (55.70%), Postives = 55/79 (69.62%), Query Frame = 1

Query:  439 DSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDG 675
            DS+    +K KK R+RTTFS +QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I +G
Sbjct:  142 DSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEG 220

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BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: ARX (aristaless related homeobox [Source:HGNC Symbol;Acc:HGNC:18060])

HSP 1 Score: 92.8189 bits (229), Expect = 4.339e-19
Identity = 41/66 (62.12%), Postives = 52/66 (78.79%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G
Sbjct:  325 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAG 390

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BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: ALX1 (ALX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:1494])

HSP 1 Score: 88.9669 bits (219), Expect = 1.393e-18
Identity = 52/125 (41.60%), Postives = 71/125 (56.80%), Query Frame = 1

Query:  295 LEEVSSNSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVT-RCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGII 666
            + +V    LH  +  A    N + +S  +  G+ +    D +  +C+S  S S      KK RHRTTF++ QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I
Sbjct:   80 ITKVEGQPLHTELNRAMDNCNSLRMSPVK--GMQEKGELDELGDKCDSNVSSS------KKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQI 196

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BLAST of Homeobox domain-containing protein vs. Ensembl Human
Match: SHOX (short stature homeobox [Source:HGNC Symbol;Acc:HGNC:10853])

HSP 1 Score: 85.8853 bits (211), Expect = 2.196e-18
Identity = 43/78 (55.13%), Postives = 57/78 (73.08%), Query Frame = 1

Query:  460 SKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD---HNGIISDGTVN 684
            +KLK+ R RT F+  QL+ LE  FD++ YPDA  RE+L+ +LG+ E+RVQVWFQNRRAK RK++   H G+I  GT N
Sbjct:  113 TKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVIL-GTAN 189

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BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: unc-4 (Homeobox protein unc-4 [Source:UniProtKB/Swiss-Prot;Acc:P29506])

HSP 1 Score: 87.8113 bits (216), Expect = 3.521e-19
Identity = 46/94 (48.94%), Postives = 58/94 (61.70%), Query Frame = 1

Query:  376 DENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHN 657
            D+N+ +N+++          ED      S  K+ R RT FS +QL  LE AF+ S YPD   RE LA +L + ESRVQVWFQNRRAKWRKR+ N
Sbjct:   62 DDNLLMNEDDG------IALEDDNDTGESAAKRRRTRTNFSGWQLEELESAFEASHYPDVFMREALAMRLDLLESRVQVWFQNRRAKWRKREQN 149

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BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: unc-30 (Homeobox protein unc-30 [Source:UniProtKB/Swiss-Prot;Acc:P52906])

HSP 1 Score: 86.6557 bits (213), Expect = 2.502e-18
Identity = 42/100 (42.00%), Postives = 67/100 (67.00%), Query Frame = 1

Query:  397 DNNHQDPVTRCNSEDSLSRHNSKLKKSR-HRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQV 693
            D+NH D  +  +S  + S +  K++K R  RT F+++QL+ LE+ F ++ YPD   RE++A  + + E RV+VWF+NRRAKWRKR+ N +I +G   ++V
Sbjct:   86 DDNHLDTSSPTDSTGNGSTNGGKIQKPRRQRTHFTSHQLTELENWFSRNRYPDMACREEIAVWISLTEPRVRVWFKNRRAKWRKRERNYVIDNGQGTTKV 185

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BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: alr-1 (AristaLess (Drosophila homeodomain) Related [Source:UniProtKB/TrEMBL;Acc:Q21836])

HSP 1 Score: 87.0409 bits (214), Expect = 2.771e-18
Identity = 43/87 (49.43%), Postives = 59/87 (67.82%), Query Frame = 1

Query:  391 LNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            L++  +  P    NS D     N K K+ R+RTTFSA+QL  LE  F ++ YPD  TRE+LA ++ + E+RVQVWFQNRRAK+RK++
Sbjct:   94 LDNRENGSPSDGTNSPDD----NGKRKQRRYRTTFSAFQLDELEKVFARTHYPDVFTREELATRVQLTEARVQVWFQNRRAKYRKQE 176

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BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: unc-30 (Homeobox protein unc-30 [Source:UniProtKB/Swiss-Prot;Acc:P52906])

HSP 1 Score: 86.6557 bits (213), Expect = 2.950e-18
Identity = 42/100 (42.00%), Postives = 67/100 (67.00%), Query Frame = 1

Query:  397 DNNHQDPVTRCNSEDSLSRHNSKLKKSR-HRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQV 693
            D+NH D  +  +S  + S +  K++K R  RT F+++QL+ LE+ F ++ YPD   RE++A  + + E RV+VWF+NRRAKWRKR+ N +I +G   ++V
Sbjct:   86 DDNHLDTSSPTDSTGNGSTNGGKIQKPRRQRTHFTSHQLTELENWFSRNRYPDMACREEIAVWISLTEPRVRVWFKNRRAKWRKRERNYVIDNGQGTTKV 185

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BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Match: ceh-10 (Homeobox protein ceh-10 [Source:UniProtKB/Swiss-Prot;Acc:P41935])

HSP 1 Score: 83.9593 bits (206), Expect = 2.799e-17
Identity = 39/64 (60.94%), Postives = 44/64 (68.75%), Query Frame = 1

Query:  460 SKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            SK KK RHRT F+ YQ+  LE AF  S YPD   RE LA K  + E R+QVWFQNRRAKWRK +
Sbjct:  132 SKRKKRRHRTIFTQYQIDELEKAFQDSHYPDIYAREVLAGKTELQEDRIQVWFQNRRAKWRKTE 195

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BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: al (gene:FBgn0000061 transcript:FBtr0078053)

HSP 1 Score: 96.6709 bits (239), Expect = 3.615e-21
Identity = 43/82 (52.44%), Postives = 60/82 (73.17%), Query Frame = 1

Query:  415 PVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            PV+  NS+     +  K K+ R+RTTF+++QL  LE AF ++ YPD  TRE+LA K+G+ E+R+QVWFQNRRAKWRK++  G
Sbjct:   66 PVSDGNSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQEKVG 147

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BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: hbn (gene:FBgn0008636 transcript:FBtr0071556)

HSP 1 Score: 92.8189 bits (229), Expect = 6.736e-20
Identity = 47/98 (47.96%), Postives = 63/98 (64.29%), Query Frame = 1

Query:  358 RMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            R D  T+ + GL+ +N  +  +  N+   LS      K  R RTTF+ +QL  LE AF+++ YPD  TRE LA +L + E+RVQVWFQNRRAKWRKR+
Sbjct:  115 REDSPTNTDGGLDVDNDDELSSSLNNGHDLSDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKRE 212

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BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Rx (gene:FBgn0020617 transcript:FBtr0342783)

HSP 1 Score: 86.6557 bits (213), Expect = 2.722e-17
Identity = 38/64 (59.38%), Postives = 50/64 (78.12%), Query Frame = 1

Query:  460 SKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            +K K  R+RTTF+ YQL  LE AF++S YPD  +RE+LA K+ + E RVQVWFQNRRAKWR+++
Sbjct:  555 AKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQE 618

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BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: Pph13 (gene:FBgn0023489 transcript:FBtr0078070)

HSP 1 Score: 82.8037 bits (203), Expect = 9.562e-17
Identity = 37/72 (51.39%), Postives = 51/72 (70.83%), Query Frame = 1

Query:  445 LSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            + +   K K+ R+RTTF+  QL  LE AF ++ YPD   RE+LA ++ + E+RVQVWFQNRRAKWRK++  G
Sbjct:    1 MDKGTMKRKQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQEKIG 72

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BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Match: PHDP (gene:FBgn0025334 transcript:FBtr0072224)

HSP 1 Score: 78.5666 bits (192), Expect = 3.552e-16
Identity = 40/77 (51.95%), Postives = 56/77 (72.73%), Query Frame = 1

Query:  433 SEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
             +D LS    K K+ R RTTF++ QL+ LE  F ++ YPD  TRE++A+KL + E+RVQVWFQNRRAK+RK++ + I
Sbjct:  100 GDDGLSL-TDKSKQRRIRTTFTSNQLNELEKIFLETHYPDIYTREEIASKLHLTEARVQVWFQNRRAKFRKQERHAI 175

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BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: arxb (aristaless related homeobox b [Source:ZFIN;Acc:ZDB-GENE-121109-2])

HSP 1 Score: 93.5893 bits (231), Expect = 4.191e-20
Identity = 41/67 (61.19%), Postives = 53/67 (79.10%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G+
Sbjct:  159 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKVGV 225

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BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: arxa (aristaless related homeobox a [Source:NCBI gene;Acc:30657])

HSP 1 Score: 94.3597 bits (233), Expect = 4.219e-20
Identity = 41/67 (61.19%), Postives = 53/67 (79.10%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G+
Sbjct:  212 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGV 278

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BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Match: alx1 (ALX homeobox 1 [Source:NCBI gene;Acc:565176])

HSP 1 Score: 88.9669 bits (219), Expect = 7.577e-19
Identity = 51/118 (43.22%), Postives = 68/118 (57.63%), Query Frame = 1

Query:  313 NSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGII 666
            +SLHAM    + R+      +    G +  +  +   +C+S  S S      KK RHRTTF++ QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I
Sbjct:   79 SSLHAMENCCSLRV------SPATSGPDKTDLDELGEKCDSNVSSS------KKRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRERYGQI 184

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Query:  313 NSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGII 666
            +SLHAM    + R+      +    G +  +  +   +C+S  S S      KK RHRTTF++ QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I
Sbjct:   79 SSLHAMENCCSLRV------SPATSGPDKTDLDELGEKCDSNVSSS------KKRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRERYGQI 184

[Close]

Query:  313 NSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGII 666
            +SLHAM    + R+      +    G +  +  +   +C+S  S S      KK RHRTTF++ QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I
Sbjct:   79 SSLHAMENCCSLRV------SPATSGPDKTDLDELGEKCDSNVSSS------KKRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRERYGQI 184

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BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000045475.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:8:38234894:38239775:1 gene:ENSXETG00000019174.1 transcript:ENSXETT00000045475.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.9669 bits (219), Expect = 1.768e-19
Identity = 44/86 (51.16%), Postives = 57/86 (66.28%), Query Frame = 1

Query:  412 DPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIIS 669
            +PV + +     S  + K K+ R+RTTFS  QL  LE AF +S YPD  TRE LA +L + E+RVQVWFQNRRAKWRKR+   ++ 
Sbjct:   32 EPVAKQSCALESSAPSGKRKQRRYRTTFSNLQLEELEMAFRKSHYPDVFTREDLAMRLDLTEARVQVWFQNRRAKWRKREKTEMLG 117

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BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000045443.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:8:38234864:38239775:1 gene:ENSXETG00000019174.1 transcript:ENSXETT00000045443.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.1965 bits (217), Expect = 1.794e-19
Identity = 45/82 (54.88%), Postives = 55/82 (67.07%), Query Frame = 1

Query:  421 TRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGII 666
            T C  E S    + K K+ R+RTTFS  QL  LE AF +S YPD  TRE LA +L + E+RVQVWFQNRRAKWRKR+   ++
Sbjct:    1 TSCALESSAP--SGKRKQRRYRTTFSNLQLEELEMAFRKSHYPDVFTREDLAMRLDLTEARVQVWFQNRRAKWRKREKTEML 80

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BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000045492.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:8:38234894:38239775:1 gene:ENSXETG00000019174.1 transcript:ENSXETT00000045492.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 87.8113 bits (216), Expect = 3.106e-19
Identity = 45/83 (54.22%), Postives = 55/83 (66.27%), Query Frame = 1

Query:  418 VTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGII 666
            V  C  E S    + K K+ R+RTTFS  QL  LE AF +S YPD  TRE LA +L + E+RVQVWFQNRRAKWRKR+   ++
Sbjct:   15 VESCALESSAP--SGKRKQRRYRTTFSNLQLEELEMAFRKSHYPDVFTREDLAMRLDLTEARVQVWFQNRRAKWRKREKTEML 95

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: ARX (aristaless related homeobox [Source:NCBI gene;Acc:100486727])

HSP 1 Score: 92.4337 bits (228), Expect = 3.918e-19
Identity = 41/66 (62.12%), Postives = 52/66 (78.79%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G
Sbjct:  298 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAG 363

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Match: ALX1 (ALX homeobox 1 [Source:NCBI gene;Acc:100489661])

HSP 1 Score: 88.1965 bits (217), Expect = 1.764e-18
Identity = 40/66 (60.61%), Postives = 48/66 (72.73%), Query Frame = 1

Query:  469 KKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGII 666
            KK RHRTTF++ QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I
Sbjct:  131 KKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQI 196

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Alx3 (aristaless-like homeobox 3 [Source:MGI Symbol;Acc:MGI:1277097])

HSP 1 Score: 90.8929 bits (224), Expect = 3.396e-21
Identity = 41/72 (56.94%), Postives = 52/72 (72.22%), Query Frame = 1

Query:  460 SKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDG 675
            +K KK R+RTTFS +QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G + +G
Sbjct:    6 TKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKMQEG 77

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BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Alx3 (aristaless-like homeobox 3 [Source:MGI Symbol;Acc:MGI:1277097])

HSP 1 Score: 92.8189 bits (229), Expect = 4.732e-20
Identity = 43/79 (54.43%), Postives = 55/79 (69.62%), Query Frame = 1

Query:  439 DSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDG 675
            DS+    +K KK R+RTTFS +QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G + +G
Sbjct:  142 DSMELAKTKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKMQEG 220

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Arx (aristaless related homeobox [Source:MGI Symbol;Acc:MGI:1097716])

HSP 1 Score: 92.8189 bits (229), Expect = 2.946e-19
Identity = 41/66 (62.12%), Postives = 52/66 (78.79%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G
Sbjct:  327 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAG 392

[Close]

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G
Sbjct:  327 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAG 392

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Match: Alx1 (ALX homeobox 1 [Source:MGI Symbol;Acc:MGI:104621])

HSP 1 Score: 88.5817 bits (218), Expect = 3.872e-19
Identity = 52/125 (41.60%), Postives = 72/125 (57.60%), Query Frame = 1

Query:  295 LEEVSSNSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVT-RCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGII 666
            + +V    LH  +  A    N + +S  +  G+ + +  D +  +C+S  S S      KK RHRTTF++ QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I
Sbjct:   80 ITKVEGQPLHTELNRAMDNCNNLRMSPVK--GMPEKSELDELGDKCDSNVSSS------KKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQI 196

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BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q06453|AL_DROME (Homeobox protein aristaless OS=Drosophila melanogaster OX=7227 GN=al PE=1 SV=2)

HSP 1 Score: 96.6709 bits (239), Expect = 3.624e-20
Identity = 43/82 (52.44%), Postives = 60/82 (73.17%), Query Frame = 1

Query:  415 PVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            PV+  NS+     +  K K+ R+RTTF+++QL  LE AF ++ YPD  TRE+LA K+G+ E+R+QVWFQNRRAKWRK++  G
Sbjct:   66 PVSDGNSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQEKVG 147

[Close]

BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|O95076|ALX3_HUMAN (Homeobox protein aristaless-like 3 OS=Homo sapiens OX=9606 GN=ALX3 PE=1 SV=2)

HSP 1 Score: 93.2041 bits (230), Expect = 2.552e-19
Identity = 44/79 (55.70%), Postives = 55/79 (69.62%), Query Frame = 1

Query:  439 DSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDG 675
            DS+    +K KK R+RTTFS +QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I +G
Sbjct:  142 DSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEG 220

[Close]

BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|O42115|ARX_DANRE (Aristaless-related homeobox protein OS=Danio rerio OX=7955 GN=arx PE=2 SV=1)

HSP 1 Score: 94.3597 bits (233), Expect = 3.185e-19
Identity = 41/67 (61.19%), Postives = 53/67 (79.10%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G+
Sbjct:  212 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGV 278

[Close]

BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|O70137|ALX3_MOUSE (Homeobox protein aristaless-like 3 OS=Mus musculus OX=10090 GN=Alx3 PE=2 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 3.310e-19
Identity = 43/79 (54.43%), Postives = 55/79 (69.62%), Query Frame = 1

Query:  439 DSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDG 675
            DS+    +K KK R+RTTFS +QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G + +G
Sbjct:  142 DSMELAKTKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKMQEG 220

[Close]

BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Match: sp|Q26657|ALX_STRPU (Aristaless homeobox protein (Fragment) OS=Strongylocentrotus purpuratus OX=7668 GN=ALX PE=2 SV=2)

HSP 1 Score: 90.8929 bits (224), Expect = 1.213e-18
Identity = 40/68 (58.82%), Postives = 54/68 (79.41%), Query Frame = 1

Query:  460 SKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
            +K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA ++ + E+RVQVWFQNRRAKWRKR+  G+
Sbjct:  208 TKRKQRRYRTTFTSYQLEELERAFCKTHYPDVFTREELAMRVDLTEARVQVWFQNRRAKWRKREKLGL 275

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BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A504YIH2 (Homeobox domain-containing protein OS=Fasciola gigantica OX=46835 GN=FGIG_04144 PE=4 SV=1)

HSP 1 Score: 111.694 bits (278), Expect = 1.044e-21
Identity = 49/75 (65.33%), Postives = 61/75 (81.33%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNS 687
            K KK+RHRTTFS +QLS+LE AFD   YPDA TRE +A+KL + ESRVQVWFQNRRAKWRK++   II++ TV++
Sbjct:  242 KSKKARHRTTFSVHQLSVLEAAFDNCPYPDAATREDIASKLALSESRVQVWFQNRRAKWRKQECGQIITNHTVST 316

[Close]

BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A4E0S3U6 (Homeobox domain-containing protein OS=Fasciola hepatica OX=6192 GN=D915_001122 PE=4 SV=1)

HSP 1 Score: 111.694 bits (278), Expect = 1.118e-21
Identity = 49/75 (65.33%), Postives = 61/75 (81.33%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNS 687
            K KK+RHRTTFS +QLS+LE AFD   YPDA TRE +A+KL + ESRVQVWFQNRRAKWRK++   II++ TV++
Sbjct:  242 KSKKARHRTTFSVHQLSVLEAAFDNCPYPDAATREDIASKLALSESRVQVWFQNRRAKWRKQECGQIITNHTVST 316

[Close]

BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A2H1CTU5 (Homeobox domain protein OS=Fasciola hepatica OX=6192 GN=D915_01522 PE=4 SV=1)

HSP 1 Score: 110.923 bits (276), Expect = 1.599e-21
Identity = 49/75 (65.33%), Postives = 61/75 (81.33%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNS 687
            K KK+RHRTTFS +QLS+LE AFD   YPDA TRE +A+KL + ESRVQVWFQNRRAKWRK++   II++ TV++
Sbjct:  186 KSKKARHRTTFSVHQLSVLEAAFDNCPYPDAATREDIASKLALSESRVQVWFQNRRAKWRKQECGQIITNHTVST 260

[Close]

BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A183AC78 (Homeobox domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS4563 PE=4 SV=1)

HSP 1 Score: 110.153 bits (274), Expect = 1.601e-21
Identity = 49/75 (65.33%), Postives = 61/75 (81.33%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNS 687
            K KK+RHRTTFS +QLS+LE AFD   YPDA TRE +A+KL + ESRVQVWFQNRRAKWRK++   I+++ TV+S
Sbjct:   86 KSKKARHRTTFSVHQLSVLEAAFDNCPYPDAVTREDIASKLALSESRVQVWFQNRRAKWRKQECGQILTNHTVSS 160

[Close]

BLAST of Homeobox domain-containing protein vs. TrEMBL
Match: A0A4Z2CW81 (Retinal homeobox protein (Fragment) OS=Schistosoma japonicum OX=6182 GN=EWB00_006956 PE=4 SV=1)

HSP 1 Score: 110.538 bits (275), Expect = 2.266e-21
Identity = 48/72 (66.67%), Postives = 59/72 (81.94%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGT 678
            K KK+RHRTTFS  QLSILE AFD   YPDA TRE +A+KL + ESRVQVWFQNRRAKWRK++ + ++++GT
Sbjct:  310 KCKKARHRTTFSVQQLSILETAFDNCPYPDAVTREDIASKLSLSESRVQVWFQNRRAKWRKQEGSQLLTNGT 381

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: arxa (aristaless related homeobox [Source:NCBI gene;Acc:103042910])

HSP 1 Score: 96.2857 bits (238), Expect = 1.062e-20
Identity = 50/98 (51.02%), Postives = 65/98 (66.33%), Query Frame = 1

Query:  376 DENIGLNDNNHQDPV-TRCNSEDSLSRHNS-KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
            DE  G  D + +D   + C S  S S     K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G+
Sbjct:  191 DEESGHGDGDAKDGEDSACLSAGSDSEEGVLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGV 288

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: arxb (aristaless-related homeobox protein-like [Source:NCBI gene;Acc:103045700])

HSP 1 Score: 93.5893 bits (231), Expect = 1.004e-19
Identity = 42/67 (62.69%), Postives = 53/67 (79.10%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  GI
Sbjct:  274 KRKQRRYRTTFTSYQLEQLERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGI 340

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: alx1 (ALX homeobox 1 [Source:NCBI gene;Acc:565176])

HSP 1 Score: 87.4261 bits (215), Expect = 1.882e-18
Identity = 39/64 (60.94%), Postives = 47/64 (73.44%), Query Frame = 1

Query:  469 KKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            KK RHRTTF++ QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G
Sbjct:  116 KKRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRERYG 179

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: alx4a (ALX homeobox 4 [Source:NCBI gene;Acc:103046081])

HSP 1 Score: 88.1965 bits (217), Expect = 1.892e-18
Identity = 40/66 (60.61%), Postives = 49/66 (74.24%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            K KK R+RTTF++YQL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G
Sbjct:  170 KGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERFG 235

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000011754.2 (visual system homeobox 1 [Source:NCBI gene;Acc:103029061])

HSP 1 Score: 86.6557 bits (213), Expect = 4.213e-18
Identity = 43/79 (54.43%), Postives = 52/79 (65.82%), Query Frame = 1

Query:  427 CNSEDSLSRHNS----KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            C S D     NS    K KK RHRT F+++QL  LE AF+++ YPD   RE LA K  + E R+QVWFQNRRAKWRKR+
Sbjct:  116 CLSGDRADGKNSANSQKRKKRRHRTVFTSHQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKRE 194

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010761.1 (pep scaffold:Pmarinus_7.0:GL476415:928307:936594:-1 gene:ENSPMAG00000009746.1 transcript:ENSPMAT00000010761.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.1586 bits (152), Expect = 6.927e-13
Identity = 32/58 (55.17%), Postives = 42/58 (72.41%), Query Frame = 1

Query:  469 KKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWR 642
            K+ R RTTF+  QL +LE  F ++ YPD   RE++A K+ + ESRVQVWF+NRRAK R
Sbjct:    5 KQRRERTTFTRAQLDVLEALFSKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 62

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: dmbx1b (diencephalon/mesencephalon homeobox 1b [Source:NCBI gene;Acc:550288])

HSP 1 Score: 68.5514 bits (166), Expect = 1.112e-12
Identity = 31/57 (54.39%), Postives = 40/57 (70.18%), Query Frame = 1

Query:  478 RHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKR 648
            R RT F+A QL  LE  F ++ YPD   RE+LA    + E+RVQVWF+NRRAK+RK+
Sbjct:   45 RSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKK 101

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: dlx5a (distal-less homeobox 5a [Source:NCBI gene;Acc:30569])

HSP 1 Score: 63.1586 bits (152), Expect = 7.005e-11
Identity = 31/69 (44.93%), Postives = 47/69 (68.12%), Query Frame = 1

Query:  457 NSKLKKSR-HRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            N K KK R  RT +S++QL+ L+  F Q+ Y     R +LAA LG+ +++V++WFQNRR+K++K   NG
Sbjct:  196 NGKPKKIRKPRTIYSSFQLAALQRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKLGKNG 264

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: barhl2 (BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050913-153])

HSP 1 Score: 56.9954 bits (136), Expect = 2.007e-10
Identity = 28/80 (35.00%), Postives = 48/80 (60.00%), Query Frame = 1

Query:  469 KKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG---IISDGTVNSQVRI 699
            K  + RT FS +QL+ LE +F++  Y   Q R +LA+ L + +++V+ W+QNRR KW+++   G   +   GT  +  R+
Sbjct:    4 KPRKARTAFSDHQLTQLERSFERQKYLSVQDRMELASSLSLSDTQVKTWYQNRRTKWKRQTAVGLEFLAEAGTYGALQRL 83

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Match: dbx1b (developing brain homeobox 1b [Source:NCBI gene;Acc:30416])

HSP 1 Score: 60.8474 bits (146), Expect = 2.282e-10
Identity = 31/81 (38.27%), Postives = 40/81 (49.38%), Query Frame = 1

Query:  484 RTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQVRINKDEQHSKL 726
            R  FS  Q   LE  F +  Y     R +LA KLG+ +S+V++WFQNRR KWR      ++S G    Q    K   H  L
Sbjct:  166 RAVFSDVQRKALEKMFQKQKYISKPDRRKLATKLGLKDSQVKIWFQNRRMKWRNSKERELLSAGGCREQTLPTKGNPHPDL 246

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Yeast
Match: YHP1 (Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication [Source:SGD;Acc:S000002859])

HSP 1 Score: 53.5286 bits (127), Expect = 4.481e-8
Identity = 24/64 (37.50%), Postives = 39/64 (60.94%), Query Frame = 1

Query:  496 SAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNS 687
            S+Y+L IL+ AFD+   P+   R +L+ +  + E  VQ+WFQN+R   +K  ++G  S   V+S
Sbjct:  181 SSYELGILQTAFDECPTPNKAKRIELSEQCNMSEKSVQIWFQNKRQAAKKHKNSGNTSHCKVHS 244

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Yeast
Match: PHO2 (Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002264])

HSP 1 Score: 48.9062 bits (115), Expect = 1.694e-6
Identity = 26/71 (36.62%), Postives = 40/71 (56.34%), Query Frame = 1

Query:  484 RTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQVR 696
            RT      L +L+  F+ +  P    R++++  +G+ E  V++WFQNRRAK RK+ H G   D   +SQ R
Sbjct:   81 RTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKKQH-GSNKDTIPSSQSR 150

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO31796 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWY2])

HSP 1 Score: 90.1225 bits (222), Expect = 5.535e-22
Identity = 40/64 (62.50%), Postives = 51/64 (79.69%), Query Frame = 1

Query:  460 SKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            +K K+ R+RTTF++YQL  LE AF ++ YPD  TRE LA K+ + E+RVQVWFQNRRAKWRKR+
Sbjct:   27 AKRKQRRYRTTFTSYQLEELERAFAKTHYPDVFTREALAVKIDLTEARVQVWFQNRRAKWRKRE 90

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO39362 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA96])

HSP 1 Score: 88.1965 bits (217), Expect = 1.669e-21
Identity = 47/72 (65.28%), Postives = 59/72 (81.94%), Query Frame = 1

Query:  436 EDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            EDS S + +K KK+R+RTTFS YQ+  LE AFD++ YPD   RE+LAAKLG+ E+R+QVWFQNRRAKWRKR+
Sbjct:    2 EDS-SANAAKKKKTRYRTTFSQYQIEELERAFDKAPYPDVFAREELAAKLGLTEARIQVWFQNRRAKWRKRE 72

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO38926 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBH9])

HSP 1 Score: 90.5077 bits (223), Expect = 3.844e-21
Identity = 40/63 (63.49%), Postives = 49/63 (77.78%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            K KK R+RTTF+AYQL  +E  F ++ YPD  TREQLA +  + E+RVQVWFQNRRAKWRKR+
Sbjct:   11 KRKKRRNRTTFTAYQLEEMERVFQKTHYPDVYTREQLALRCALTEARVQVWFQNRRAKWRKRE 73

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO39160 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAY2])

HSP 1 Score: 87.4261 bits (215), Expect = 6.807e-21
Identity = 43/83 (51.81%), Postives = 56/83 (67.47%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD----HNGIISD-GTVNSQVR 696
            K KK RHRT F+ YQL  LE AF +S YPD   RE L+ K+ + E R+QVWFQNRRAKWRK++    H+ I+++ G   + VR
Sbjct:    2 KAKKRRHRTIFTNYQLEELEKAFKESHYPDVYARENLSLKIDLPEDRIQVWFQNRRAKWRKKEKCWGHSSIMAEYGLYGAMVR 84

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Match: EDO42103 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2G7])

HSP 1 Score: 88.9669 bits (219), Expect = 3.264e-20
Identity = 41/74 (55.41%), Postives = 52/74 (70.27%), Query Frame = 1

Query:  430 NSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            + E+S        K  R RTTF+ YQL  LE AF+++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+
Sbjct:    6 SGEESAGEDGKPRKVRRSRTTFTTYQLHQLERAFEKTQYPDVFTREELALRLDLSEARVQVWFQNRRAKWRKRE 79

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: arx (aristaless related homeobox [Source:NCBI gene;Acc:100144363])

HSP 1 Score: 93.9745 bits (232), Expect = 5.852e-20
Identity = 41/67 (61.19%), Postives = 53/67 (79.10%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G+
Sbjct:  219 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGV 285

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: arx (aristaless related homeobox [Source:NCBI gene;Acc:100144363])

HSP 1 Score: 93.9745 bits (232), Expect = 8.013e-20
Identity = 41/67 (61.19%), Postives = 53/67 (79.10%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G+
Sbjct:  219 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGV 285

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: arx (aristaless related homeobox [Source:NCBI gene;Acc:100144363])

HSP 1 Score: 93.5893 bits (231), Expect = 9.448e-20
Identity = 41/67 (61.19%), Postives = 53/67 (79.10%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGI 663
            K K+ R+RTTF++YQL  LE AF ++ YPD  TRE+LA +L + E+RVQVWFQNRRAKWRKR+  G+
Sbjct:  219 KRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGV 285

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: alx1 (ALX homeobox 1 [Source:NCBI gene;Acc:101154901])

HSP 1 Score: 88.1965 bits (217), Expect = 1.123e-18
Identity = 40/66 (60.61%), Postives = 48/66 (72.73%), Query Frame = 1

Query:  469 KKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGII 666
            KK RHRTTF++ QL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G I
Sbjct:  123 KKRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRERYGQI 188

[Close]

BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Match: alx4b (homeobox protein aristaless-like 4 [Source:NCBI gene;Acc:101168948])

HSP 1 Score: 88.5817 bits (218), Expect = 1.596e-18
Identity = 40/66 (60.61%), Postives = 49/66 (74.24%), Query Frame = 1

Query:  463 KLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNG 660
            K KK R+RTTF++YQL  LE  F ++ YPD   REQLA +  + E+RVQVWFQNRRAKWRKR+  G
Sbjct:  170 KGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERFG 235

[Close]

BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000016670.1 (SMESG000016670.1)

HSP 1 Score: 629.787 bits (1623), Expect = 0.000e+0
Identity = 497/497 (100.00%), Postives = 497/497 (100.00%), Query Frame = 1

Query:  196 MEVSRWISENTLSSMQLKDQEQLVAAQLERLKQLEEVSSNSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQVRINKDEQHSKLMRSTNQLFSEQNAAPGHTKTEPISITDFSSLSKQCXXXXXXXXXXXXXXXXYLHSTTGGLHPLDLYALSKLSPHENNNKNNLDSSLFSLPNTNMSDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPXXXXXXXXXXXXXXXXXXXXIQKSPAEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYNPVTGSNPSPIYPDTSNMGPXXXXXXXXXXXXXXXXXKQAISQLVQTAXXXXXXXXXXXXXXXXXXXLKRQSPIKQQPPXXXXXXXXXXXXXXXXXXHRLPSTERDSRSYSEAISNSTTVT 1686
            MEVSRWISENTLSSMQLKDQEQLVAAQLERLKQLEEVSSNSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQVRINKDEQHSKLMRSTNQLFSEQNAAPGHTKTEPISITDFSSLSKQCNTTSNSNSSVSASLSNYLHSTTGGLHPLDLYALSKLSPHENNNKNNLDSSLFSLPNTNMSDILNNIPSLLQPLPPPYSIPSNTESTNKNSNTVTSSTNPLSGLSSLYSSLSHQSDSLNSIQKSPAELLQQYYQQLTLSLPNSSHSLLSIPPPPPPPPIPLSSIYNPVTGSNPSPIYPDTSNMGPFYQQLLFQQYSQALSQYKQAISQLVQTAQSNQTNSKSDSKSSDNETNLKRQSPIKQQPPTSSSFTDNLNSSSFFNFLHRLPSTERDSRSYSEAISNSTTVT
Sbjct:    1 MEVSRWISENTLSSMQLKDQEQLVAAQLERLKQLEEVSSNSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQVRINKDEQHSKLMRSTNQLFSEQNAAPGHTKTEPISITDFSSLSKQCNTTSNSNSSVSASLSNYLHSTTGGLHPLDLYALSKLSPHENNNKNNLDSSLFSLPNTNMSDILNNIPSLLQPLPPPYSIPSNTESTNKNSNTVTSSTNPLSGLSSLYSSLSHQSDSLNSIQKSPAELLQQYYQQLTLSLPNSSHSLLSIPPPPPPPPIPLSSIYNPVTGSNPSPIYPDTSNMGPFYQQLLFQQYSQALSQYKQAISQLVQTAQSNQTNSKSDSKSSDNETNLKRQSPIKQQPPTSSSFTDNLNSSSFFNFLHRLPSTERDSRSYSEAISNSTTVT 497

[Close]

BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000016670.1 (SMESG000016670.1)

HSP 1 Score: 601.668 bits (1550), Expect = 0.000e+0
Identity = 483/483 (100.00%), Postives = 483/483 (100.00%), Query Frame = 1

Query:  238 MQLKDQEQLVAAQLERLKQLEEVSSNSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQVRINKDEQHSKLMRSTNQLFSEQNAAPGHTKTEPISITDFSSLSKQCXXXXXXXXXXXXXXXXYLHSTTGGLHPLDLYALSKLSPHENNNKNNLDSSLFSLPNTNMSDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPXXXXXXXXXXXXXXXXXXXXIQKSPAEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYNPVTGSNPSPIYPDTSNMGPXXXXXXXXXXXXXXXXXKQAISQLVQTAXXXXXXXXXXXXXXXXXXXLKRQSPIKQQPPXXXXXXXXXXXXXXXXXXHRLPSTERDSRSYSEAISNSTTVT 1686
            MQLKDQEQLVAAQLERLKQLEEVSSNSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQVRINKDEQHSKLMRSTNQLFSEQNAAPGHTKTEPISITDFSSLSKQCNTTSNSNSSVSASLSNYLHSTTGGLHPLDLYALSKLSPHENNNKNNLDSSLFSLPNTNMSDILNNIPSLLQPLPPPYSIPSNTESTNKNSNTVTSSTNPLSGLSSLYSSLSHQSDSLNSIQKSPAELLQQYYQQLTLSLPNSSHSLLSIPPPPPPPPIPLSSIYNPVTGSNPSPIYPDTSNMGPFYQQLLFQQYSQALSQYKQAISQLVQTAQSNQTNSKSDSKSSDNETNLKRQSPIKQQPPTSSSFTDNLNSSSFFNFLHRLPSTERDSRSYSEAISNSTTVT
Sbjct:    1 MQLKDQEQLVAAQLERLKQLEEVSSNSLHAMVAAANHRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRDHNGIISDGTVNSQVRINKDEQHSKLMRSTNQLFSEQNAAPGHTKTEPISITDFSSLSKQCNTTSNSNSSVSASLSNYLHSTTGGLHPLDLYALSKLSPHENNNKNNLDSSLFSLPNTNMSDILNNIPSLLQPLPPPYSIPSNTESTNKNSNTVTSSTNPLSGLSSLYSSLSHQSDSLNSIQKSPAELLQQYYQQLTLSLPNSSHSLLSIPPPPPPPPIPLSSIYNPVTGSNPSPIYPDTSNMGPFYQQLLFQQYSQALSQYKQAISQLVQTAQSNQTNSKSDSKSSDNETNLKRQSPIKQQPPTSSSFTDNLNSSSFFNFLHRLPSTERDSRSYSEAISNSTTVT 483

[Close]

BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000020038.1 (SMESG000020038.1)

HSP 1 Score: 92.0485 bits (227), Expect = 1.344e-19
Identity = 42/80 (52.50%), Postives = 56/80 (70.00%), Query Frame = 1

Query:  418 VTRCNSED--SLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            +  C+  D  S +   +K KK R+RTTFS+YQL  +E  F ++ YPD   REQLA + G+ E+RVQVWFQNRRAKWRK++
Sbjct:   45 IQSCSKSDNGSANSEEAKKKKRRNRTTFSSYQLDEMERIFQKTHYPDVYAREQLAFRTGLSEARVQVWFQNRRAKWRKKE 124

[Close]

BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000033843.1 (SMESG000033843.1)

HSP 1 Score: 88.1965 bits (217), Expect = 3.403e-19
Identity = 42/73 (57.53%), Postives = 54/73 (73.97%), Query Frame = 1

Query:  433 SEDSLSRHNSKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD 651
            S D LS  N K +  R+RTTF+ YQL  LE AF++S YPD  +RE+LA K+ + E RVQVWFQNRRAKWR+++
Sbjct:   79 SPDRLSNCNKKHR--RNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKISLPEVRVQVWFQNRRAKWRRQE 149

[Close]

BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Match: SMESG000080420.1 (SMESG000080420.1)

HSP 1 Score: 88.5817 bits (218), Expect = 9.804e-19
Identity = 45/92 (48.91%), Postives = 61/92 (66.30%), Query Frame = 1

Query:  460 SKLKKSRHRTTFSAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRKRD-HNGIISDGTVNSQ-VRINKDEQHSKLM 729
            S+ K+ R+RTTF+  QL  LE AF Q+ YPD  TRE+LA ++ + E+RVQVWFQNRRAKWRK +    +  +  +N Q  R N   QH+ L+
Sbjct:   26 SRRKQRRNRTTFTMQQLEELEKAFQQTHYPDVFTREELALRISLTEARVQVWFQNRRAKWRKTERFQPLQQNSGINDQHFRSNNSNQHTNLL 117

The following BLAST results are available for this feature:

BLAST of Homeobox domain-containing protein vs. Ensembl Human
BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
BLAST of Homeobox domain-containing protein vs. Ensembl Fly
BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
BLAST of Homeobox domain-containing protein vs. TrEMBL
BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
BLAST of Homeobox domain-containing protein vs. Ensembl Yeast
BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
BLAST of Homeobox domain-containing protein vs. Planmine SMEST

BLAST of Homeobox domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ALX3	3.541e-20	59.15	ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449]	[more]
ALX3	5.314e-20	55.70	ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449]	[more]
ARX	4.339e-19	62.12	aristaless related homeobox [Source:HGNC Symbol;Ac...	[more]
ALX1	1.393e-18	41.60	ALX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:1494]	[more]
SHOX	2.196e-18	55.13	short stature homeobox [Source:HGNC Symbol;Acc:HGN...	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
unc-4	3.521e-19	48.94	Homeobox protein unc-4 [Source:UniProtKB/Swiss-Pr...	[more]
unc-30	2.502e-18	42.00	Homeobox protein unc-30 [Source:UniProtKB/Swiss-P...	[more]
alr-1	2.771e-18	49.43	AristaLess (Drosophila homeodomain) Related [Sour...	[more]
unc-30	2.950e-18	42.00	Homeobox protein unc-30 [Source:UniProtKB/Swiss-P...	[more]
ceh-10	2.799e-17	60.94	Homeobox protein ceh-10 [Source:UniProtKB/Swiss-P...	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
al	3.615e-21	52.44	gene:FBgn0000061 transcript:FBtr0078053	[more]
hbn	6.736e-20	47.96	gene:FBgn0008636 transcript:FBtr0071556	[more]
Rx	2.722e-17	59.38	gene:FBgn0020617 transcript:FBtr0342783	[more]
Pph13	9.562e-17	51.39	gene:FBgn0023489 transcript:FBtr0078070	[more]
PHDP	3.552e-16	51.95	gene:FBgn0025334 transcript:FBtr0072224	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
arxb	4.191e-20	61.19	aristaless related homeobox b [Source:ZFIN;Acc:ZDB...	[more]
arxa	4.219e-20	61.19	aristaless related homeobox a [Source:NCBI gene;Ac...	[more]
alx1	7.577e-19	43.22	ALX homeobox 1 [Source:NCBI gene;Acc:565176]	[more]
alx1	7.577e-19	43.22	ALX homeobox 1 [Source:NCBI gene;Acc:565176]	[more]
alx1	7.577e-19	43.22	ALX homeobox 1 [Source:NCBI gene;Acc:565176]	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSXETT00000045475.1	1.768e-19	51.16	pep primary_assembly:Xenopus_tropicalis_v9.1:8:382...	[more]
ENSXETT00000045443.1	1.794e-19	54.88	pep primary_assembly:Xenopus_tropicalis_v9.1:8:382...	[more]
ENSXETT00000045492.1	3.106e-19	54.22	pep primary_assembly:Xenopus_tropicalis_v9.1:8:382...	[more]
ARX	3.918e-19	62.12	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
ALX1	1.764e-18	60.61	ALX homeobox 1 [Source:NCBI gene;Acc:100489661]	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Alx3	3.396e-21	56.94	aristaless-like homeobox 3 [Source:MGI Symbol;Acc:...	[more]
Alx3	4.732e-20	54.43	aristaless-like homeobox 3 [Source:MGI Symbol;Acc:...	[more]
Arx	2.946e-19	62.12	aristaless related homeobox [Source:MGI Symbol;Acc...	[more]
Arx	2.946e-19	62.12	aristaless related homeobox [Source:MGI Symbol;Acc...	[more]
Alx1	3.872e-19	41.60	ALX homeobox 1 [Source:MGI Symbol;Acc:MGI:104621]	[more]

BLAST of Homeobox domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q06453\|AL_DROME	3.624e-20	52.44	Homeobox protein aristaless OS=Drosophila melanoga...	[more]
sp\|O95076\|ALX3_HUMAN	2.552e-19	55.70	Homeobox protein aristaless-like 3 OS=Homo sapiens...	[more]
sp\|O42115\|ARX_DANRE	3.185e-19	61.19	Aristaless-related homeobox protein OS=Danio rerio...	[more]
sp\|O70137\|ALX3_MOUSE	3.310e-19	54.43	Homeobox protein aristaless-like 3 OS=Mus musculus...	[more]
sp\|Q26657\|ALX_STRPU	1.213e-18	58.82	Aristaless homeobox protein (Fragment) OS=Strongyl...	[more]

BLAST of Homeobox domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A504YIH2	1.044e-21	65.33	Homeobox domain-containing protein OS=Fasciola gig...	[more]
A0A4E0S3U6	1.118e-21	65.33	Homeobox domain-containing protein OS=Fasciola hep...	[more]
A0A2H1CTU5	1.599e-21	65.33	Homeobox domain protein OS=Fasciola hepatica OX=61...	[more]
A0A183AC78	1.601e-21	65.33	Homeobox domain-containing protein OS=Echinostoma ...	[more]
A0A4Z2CW81	2.266e-21	66.67	Retinal homeobox protein (Fragment) OS=Schistosoma...	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
arxa	1.062e-20	51.02	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
arxb	1.004e-19	62.69	aristaless-related homeobox protein-like [Source:N...	[more]
alx1	1.882e-18	60.94	ALX homeobox 1 [Source:NCBI gene;Acc:565176]	[more]
alx4a	1.892e-18	60.61	ALX homeobox 4 [Source:NCBI gene;Acc:103046081]	[more]
ENSAMXT00000011754.2	4.213e-18	54.43	visual system homeobox 1 [Source:NCBI gene;Acc:103...	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000010761.1	6.927e-13	55.17	pep scaffold:Pmarinus_7.0:GL476415:928307:936594:-...	[more]
dmbx1b	1.112e-12	54.39	diencephalon/mesencephalon homeobox 1b [Source:NCB...	[more]
dlx5a	7.005e-11	44.93	distal-less homeobox 5a [Source:NCBI gene;Acc:3056...	[more]
barhl2	2.007e-10	35.00	BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050...	[more]
dbx1b	2.282e-10	38.27	developing brain homeobox 1b [Source:NCBI gene;Acc...	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
YHP1	4.481e-8	37.50	Homeobox transcriptional repressor; binds Mcm1p an...	[more]
PHO2	1.694e-6	36.62	Homeobox transcription factor; regulatory targets ...	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO31796	5.535e-22	62.50	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39362	1.669e-21	65.28	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38926	3.844e-21	63.49	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39160	6.807e-21	51.81	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42103	3.264e-20	55.41	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Homeobox domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
arx	5.852e-20	61.19	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
arx	8.013e-20	61.19	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
arx	9.448e-20	61.19	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
alx1	1.123e-18	60.61	ALX homeobox 1 [Source:NCBI gene;Acc:101154901]	[more]
alx4b	1.596e-18	60.61	homeobox protein aristaless-like 4 [Source:NCBI ge...	[more]

BLAST of Homeobox domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000016670.1	0.000e+0	100.00	SMESG000016670.1	[more]
SMESG000016670.1	0.000e+0	100.00	SMESG000016670.1	[more]
SMESG000020038.1	1.344e-19	52.50	SMESG000020038.1	[more]
SMESG000033843.1	3.403e-19	57.53	SMESG000033843.1	[more]
SMESG000080420.1	9.804e-19	48.91	SMESG000080420.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30008752 ID=SMED30008752|Name=Homeobox domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1837bp
ATTATTATTATTATTATTATTTTTCCCTGGTACTCATCTTCAAATCAAAG
CAACATCAACAAGAGAGAAAAAGGAAAAAAACAAACTTTATCAACCAGAA
ACTTAATGAAAGAATCTTTACAACAGAGTTTCCAATAACAGCTTTTTTTA
TATATTTATTTTTTTTCCAAATCAAAAAAAAAACACCCCGTCAAAATGGA
AGTTTCACGTTGGATCTCAGAGAACACTCTTTCATCAATGCAACTGAAAG
ATCAAGAACAATTAGTGGCAGCTCAATTGGAACGATTGAAACAATTGGAA
GAGGTCTCGTCGAACAGTTTGCACGCAATGGTAGCCGCAGCGAACCACAG
ACTCAATCGGATGGATGTAAGCACCGATGAAAATATCGGCCTCAACGACA
ACAATCACCAAGATCCCGTAACCCGATGCAATTCTGAAGACTCATTATCC
CGACATAATAGTAAATTAAAAAAATCAAGACATAGGACAACGTTTTCTGC
GTATCAATTATCAATACTCGAACACGCGTTCGACCAATCAGCATATCCCG
ATGCACAAACTCGCGAACAGCTCGCCGCAAAACTAGGAATCGGAGAATCA
CGCGTTCAAGTCTGGTTTCAAAATAGACGTGCAAAATGGCGTAAACGTGA
TCACAATGGAATTATCTCAGATGGAACAGTAAACTCACAAGTTCGAATAA
ACAAAGACGAACAACATTCAAAATTGATGCGTTCAACCAATCAACTTTTC
TCGGAGCAAAATGCTGCTCCCGGTCACACGAAAACCGAGCCCATATCAAT
AACGGATTTCAGTTCCTTATCCAAGCAATGTAACACAACATCGAATTCCA
ATTCCTCTGTATCGGCCAGTCTTTCAAATTACCTTCATTCAACTACAGGA
GGCTTGCATCCATTAGATTTGTATGCCTTATCAAAACTTTCACCTCATGA
AAATAACAACAAAAACAATTTGGACTCATCGCTATTTTCACTTCCAAACA
CAAATATGTCAGATATTCTTAACAATATTCCTTCTCTCCTTCAGCCATTA
CCTCCTCCATATTCTATACCCTCGAATACAGAATCCACTAACAAAAACAG
CAATACGGTGACATCAAGTACGAATCCACTGTCAGGTCTGAGTAGTTTGT
ATTCTAGTTTATCACATCAAAGTGATTCATTAAATTCCATTCAAAAAAGT
CCAGCAGAATTGCTGCAACAATATTATCAACAGTTGACATTGTCATTACC
GAATTCGTCACACAGCCTCCTTTCAATTCCTCCTCCTCCTCCACCGCCAC
CCATTCCATTATCATCAATTTACAATCCAGTCACTGGATCCAATCCATCC
CCAATCTATCCCGACACATCGAATATGGGTCCATTTTATCAGCAGCTCCT
TTTCCAGCAATATTCTCAAGCTCTTTCTCAATATAAACAAGCAATATCAC
AATTGGTCCAAACCGCCCAATCCAATCAAACGAATTCAAAATCAGATTCC
AAGTCCTCTGATAACGAGACGAATTTAAAACGACAATCTCCGATTAAACA
ACAGCCCCCGACATCAAGCTCATTTACAGATAATCTCAACTCCAGTTCGT
TTTTTAACTTTTTACATAGACTGCCCTCAACAGAAAGAGACTCGAGAAGC
TACTCGGAGGCCATTAGCAATTCGACCACAGTTACGTGATTTTGTATAGT
TAAACTTCGCTATCAGCACTGATTTGCACTTGTTTTGTATTGCACTTTTT
CACTCTCATTGTACAGATAATCGGTTACAATCTTGTAACTCTGATGTTGT
TGATTTGAATTTGATAATAAATAATCTTGAACTCGAA

protein sequence of SMED30008752-orf-1

>SMED30008752-orf-1 ID=SMED30008752-orf-1|Name=SMED30008752-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=498bp
MEVSRWISENTLSSMQLKDQEQLVAAQLERLKQLEEVSSNSLHAMVAAAN
HRLNRMDVSTDENIGLNDNNHQDPVTRCNSEDSLSRHNSKLKKSRHRTTF
SAYQLSILEHAFDQSAYPDAQTREQLAAKLGIGESRVQVWFQNRRAKWRK
RDHNGIISDGTVNSQVRINKDEQHSKLMRSTNQLFSEQNAAPGHTKTEPI
SITDFSSLSKQCNTTSNSNSSVSASLSNYLHSTTGGLHPLDLYALSKLSP
HENNNKNNLDSSLFSLPNTNMSDILNNIPSLLQPLPPPYSIPSNTESTNK
NSNTVTSSTNPLSGLSSLYSSLSHQSDSLNSIQKSPAELLQQYYQQLTLS
LPNSSHSLLSIPPPPPPPPIPLSSIYNPVTGSNPSPIYPDTSNMGPFYQQ
LLFQQYSQALSQYKQAISQLVQTAQSNQTNSKSDSKSSDNETNLKRQSPI
KQQPPTSSSFTDNLNSSSFFNFLHRLPSTERDSRSYSEAISNSTTVT*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0002111	X2 cell
PLANA:0003117	parapharyngeal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000047	HTH_motif
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 17..37
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 78..154 e-value: 4.1E-28 score: 98.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 75..95
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 425..461
None	No IPR available	PANTHER	PTHR24329:SF534	DORSAL ROOT GANGLIA HOMEOBOX, ISOFORM E-RELATED	coord: 68..451
None	No IPR available	PANTHER	PTHR24329	FAMILY NOT NAMED	coord: 68..451
IPR000047	Helix-turn-helix motif	PRINTS	PR00031	HTHREPRESSR	coord: 122..131 score: 52.04 coord: 131..147 score: 52.71
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 93..155 e-value: 4.6E-27 score: 105.9
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 95..150 e-value: 1.9E-24 score: 85.3
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 91..151 score: 20.342
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 95..151 e-value: 5.85603E-22 score: 86.9136
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 126..149
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 89..152