Serine/threonine-protein kinase

Overview
NameSerine/threonine-protein kinase
Smed IDSMED30008746
Length (bp)599
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Serine/threonine-protein kinase (SMED30008746) t-SNE clustered cells

Violin plots show distribution of expression levels for Serine/threonine-protein kinase (SMED30008746) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Serine/threonine-protein kinase (SMED30008746) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Serine/threonine-protein kinase (SMED30008746) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30008746

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
body wall musculatureSMED30008746h1SMcG0001613 dd_Smed_v4_14648_0_1dd_Smed_v4PMID:30471994
Scimone et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
zeta neoblastSMED30008746h1SMcG0001613 dd_Smed_v4_14648_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30008746h1SMcG0001613 SMED_08691_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30008746h1SMcG0018500 SMED_08691_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30008746h1SMcG0018504 SMED_08691_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30008746h1SMcG0018502 SMED_08691_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30008746h1SMcG0018503 SMED_08691_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: RPS6KA5 (ribosomal protein S6 kinase A5 [Source:HGNC Symbol;Acc:HGNC:10434])

HSP 1 Score: 62.003 bits (149), Expect = 6.830e-11
Identity = 47/170 (27.65%), Postives = 80/170 (47.06%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKE--TLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN++   E   LE+K+ID         D     +   TL + +PE+     Y+    L  + G + Y  L  +VPF+S   +  C      + KI             N+S E A+  I   + +DP++R++   L  ++WL +  +++S NP+
Sbjct:  532 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL-WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQE-AKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSS-NPL 698
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: RPS6KA5 (ribosomal protein S6 kinase A5 [Source:HGNC Symbol;Acc:HGNC:10434])

HSP 1 Score: 62.003 bits (149), Expect = 6.952e-11
Identity = 47/170 (27.65%), Postives = 80/170 (47.06%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKE--TLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN++   E   LE+K+ID         D     +   TL + +PE+     Y+    L  + G + Y  L  +VPF+S   +  C      + KI             N+S E A+  I   + +DP++R++   L  ++WL +  +++S NP+
Sbjct:  453 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL-WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQE-AKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSS-NPL 619
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: CAMK1G (calcium/calmodulin dependent protein kinase IG [Source:HGNC Symbol;Acc:HGNC:14585])

HSP 1 Score: 56.6102 bits (135), Expect = 4.805e-9
Identity = 43/148 (29.05%), Postives = 71/148 (47.97%), Query Frame = 1 
Query:   73 MSEIGYYHRDIKPENIM--VNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVC-TFGCVAYFCLEFRVPFKSEIETK----------KCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            + E G  HRD+KPEN++    +E  ++ + D      +Q  I   ++  GT G+ +PE+    PY+  +++ C + G + Y  L    PF  E E+K          +   P  +  SE A+ FI   ++ DP+ER      LSH W+
Sbjct:   38 LHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGI--MSTACGTPGYVAPEVLAQKPYS--KAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 181
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: PIM3 (Pim-3 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:19310])

HSP 1 Score: 56.225 bits (134), Expect = 5.076e-9
Identity = 39/141 (27.66%), Postives = 64/141 (45.39%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLID------LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKD 489
            G  HRDIK EN++V+  + E+KLID      L+D ++  +D        GT  +  PE      Y+ + + V + G + Y  +   +PF+ + E  +  L      S   +  I  C+ L P ER     + +H W+   D
Sbjct:  165 GVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFD--------GTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGAD 297
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Match: CAMK1G (calcium/calmodulin dependent protein kinase IG [Source:HGNC Symbol;Acc:HGNC:14585])

HSP 1 Score: 56.225 bits (134), Expect = 5.918e-9
Identity = 43/148 (29.05%), Postives = 71/148 (47.97%), Query Frame = 1 
Query:   73 MSEIGYYHRDIKPENIM--VNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVC-TFGCVAYFCLEFRVPFKSEIETK----------KCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            + E G  HRD+KPEN++    +E  ++ + D      +Q  I   ++  GT G+ +PE+    PY+  +++ C + G + Y  L    PF  E E+K          +   P  +  SE A+ FI   ++ DP+ER      LSH W+
Sbjct:  134 LHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGI--MSTACGTPGYVAPEVLAQKPYS--KAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: pig-1 (Maternal embryonic leucine zipper kinase [Source:UniProtKB/Swiss-Prot;Acc:U4PR86])

HSP 1 Score: 62.7734 bits (151), Expect = 1.535e-11
Identity = 43/146 (29.45%), Postives = 73/146 (50.00%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDL------EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKS---EIETKKCN---LPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNK 486
            GY HRD+KPEN+++  E L +KLID       E    D++++  C    G+  + +PE+   + Y   ++ V + G + Y  L   +PF+    +I  KK       +    S L++  +   +++ P+ RI    LL HDWL +K
Sbjct:  127 GYAHRDLKPENLLLT-EDLHLKLIDFGLCAKTEKGRIDKHNLDTC---CGSPAYAAPELIQGLQYKGNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWLNHK 268
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: pig-1 (Maternal embryonic leucine zipper kinase [Source:UniProtKB/Swiss-Prot;Acc:U4PR86])

HSP 1 Score: 62.7734 bits (151), Expect = 1.754e-11
Identity = 43/146 (29.45%), Postives = 73/146 (50.00%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDL------EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKS---EIETKKCN---LPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNK 486
            GY HRD+KPEN+++  E L +KLID       E    D++++  C    G+  + +PE+   + Y   ++ V + G + Y  L   +PF+    +I  KK       +    S L++  +   +++ P+ RI    LL HDWL +K
Sbjct:  127 GYAHRDLKPENLLLT-EDLHLKLIDFGLCAKTEKGRIDKHNLDTC---CGSPAYAAPELIQGLQYKGNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWLNHK 268
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: pig-1 (Maternal embryonic leucine zipper kinase [Source:UniProtKB/Swiss-Prot;Acc:U4PR86])

HSP 1 Score: 62.3882 bits (150), Expect = 1.888e-11
Identity = 43/146 (29.45%), Postives = 73/146 (50.00%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDL------EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKS---EIETKKCN---LPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNK 486
            GY HRD+KPEN+++  E L +KLID       E    D++++  C    G+  + +PE+   + Y   ++ V + G + Y  L   +PF+    +I  KK       +    S L++  +   +++ P+ RI    LL HDWL +K
Sbjct:  127 GYAHRDLKPENLLLT-EDLHLKLIDFGLCAKTEKGRIDKHNLDTC---CGSPAYAAPELIQGLQYKGNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWLNHK 268
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: pig-1 (Maternal embryonic leucine zipper kinase [Source:UniProtKB/Swiss-Prot;Acc:U4PR86])

HSP 1 Score: 62.3882 bits (150), Expect = 1.926e-11
Identity = 43/146 (29.45%), Postives = 73/146 (50.00%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDL------EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKS---EIETKKCN---LPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNK 486
            GY HRD+KPEN+++  E L +KLID       E    D++++  C    G+  + +PE+   + Y   ++ V + G + Y  L   +PF+    +I  KK       +    S L++  +   +++ P+ RI    LL HDWL +K
Sbjct:  127 GYAHRDLKPENLLLT-EDLHLKLIDFGLCAKTEKGRIDKHNLDTC---CGSPAYAAPELIQGLQYKGNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWLNHK 268
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Match: cmk-1 (Calcium/calmodulin-dependent protein kinase type 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9TXJ0])

HSP 1 Score: 61.2326 bits (147), Expect = 4.134e-11
Identity = 52/195 (26.67%), Postives = 85/195 (43.59%), Query Frame = 1 
Query:   73 MSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETK----------KCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL-----YNKD---KITSYNPMAIAKSLWNIFSN---LIKS*ILFLISNKSN 594
            M + G  HRD+KPEN++   +  + K++  +  L    D  +  +  GT G+ +PE+    PY  K   V + G +AY  L    PF  E +            + + P  +  S+ A+ FIT  +  DP+ R    D LSH W+     Y  D    +  +   ++AK  W    N    I+   +  +S+ SN
Sbjct:  135 MHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGLSKTEDSGVMATACGTPGYVAPEVLQQKPYG-KAVDVWSIGVIAYILLCGYPPFYDESDANLFAQIIKGEYEFDAPYWDQISDSAKDFITHLMCCDPEARFTCQDALSHPWISGNTAYTHDIHGTVAVHLKKSLAKRNWKKAYNAAAAIRQLQMLRLSSNSN 328
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0333673)

HSP 1 Score: 56.225 bits (134), Expect = 2.847e-9
Identity = 40/151 (26.49%), Postives = 68/151 (45.03%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETK-----KCNL-----PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITS 501
            G  HRD+KPEN+++  +     VKL D    +  Q D        GT G+ SPE+    PY  K   +   G + Y  L    PF  E + +     K        P+ +  +  A++ I   + ++P++RI   + L H W+  ++++ S
Sbjct:  131 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYG-KSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVAS 280
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0300377)

HSP 1 Score: 56.225 bits (134), Expect = 3.361e-9
Identity = 40/151 (26.49%), Postives = 68/151 (45.03%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETK-----KCNL-----PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITS 501
            G  HRD+KPEN+++  +     VKL D    +  Q D        GT G+ SPE+    PY  K   +   G + Y  L    PF  E + +     K        P+ +  +  A++ I   + ++P++RI   + L H W+  ++++ S
Sbjct:  131 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYG-KSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVAS 280
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0089217)

HSP 1 Score: 56.225 bits (134), Expect = 3.361e-9
Identity = 40/151 (26.49%), Postives = 68/151 (45.03%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETK-----KCNL-----PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITS 501
            G  HRD+KPEN+++  +     VKL D    +  Q D        GT G+ SPE+    PY  K   +   G + Y  L    PF  E + +     K        P+ +  +  A++ I   + ++P++RI   + L H W+  ++++ S
Sbjct:  131 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYG-KSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVAS 280
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0089218)

HSP 1 Score: 56.225 bits (134), Expect = 3.361e-9
Identity = 40/151 (26.49%), Postives = 68/151 (45.03%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETK-----KCNL-----PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITS 501
            G  HRD+KPEN+++  +     VKL D    +  Q D        GT G+ SPE+    PY  K   +   G + Y  L    PF  E + +     K        P+ +  +  A++ I   + ++P++RI   + L H W+  ++++ S
Sbjct:  131 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYG-KSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVAS 280
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Match: CaMKII (gene:FBgn0264607 transcript:FBtr0333675)

HSP 1 Score: 56.225 bits (134), Expect = 3.391e-9
Identity = 40/151 (26.49%), Postives = 68/151 (45.03%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETK-----KCNL-----PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITS 501
            G  HRD+KPEN+++  +     VKL D    +  Q D        GT G+ SPE+    PY  K   +   G + Y  L    PF  E + +     K        P+ +  +  A++ I   + ++P++RI   + L H W+  ++++ S
Sbjct:  131 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYG-KSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVAS 280
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: pimr72 (Pim proto-oncogene, serine/threonine kinase, related 72 [Source:ZFIN;Acc:ZDB-GENE-091118-122])

HSP 1 Score: 67.781 bits (164), Expect = 1.912e-13
Identity = 48/133 (36.09%), Postives = 67/133 (50.38%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDL--EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIE-TKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDW 474
            G  HRDIK EN+++NKETLEVKLID    D+L        C    GT  +  PE      Y+ K + V + G + Y  L    P  S+++ T +    K  LS+E  +  +  C++  P +RI  G L SH W
Sbjct:  135 GVLHRDIKLENLLINKETLEVKLIDFGCGDLLKTSAYTTFC----GTEDYCPPEFRSSGRYHGKAATVWSLGVLLYELLCGEPPKHSDLDLTDERTWIKSGLSTECCQ-LVQSCLQRSPRKRIALGKLSSHRW 262
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: si:dkey-58b18.6 (si:dkey-58b18.6 [Source:ZFIN;Acc:ZDB-GENE-070912-566])

HSP 1 Score: 66.6254 bits (161), Expect = 2.733e-13
Identity = 46/134 (34.33%), Postives = 67/134 (50.00%), Query Frame = 1 
Query:   94 HRDIKPENIMVNKETLEVKLID------LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            HRDIK EN+++N +TLEVKLID      LED  +  Y         GT  ++ PE      Y+ + + V + G V +  L ++ P + E+ T       I   SE    F+  C+K+DP ERI+   L  H W+
Sbjct:   89 HRDIKLENLLINPDTLEVKLIDFGCGDILEDEAYTDYS--------GTAEYRPPEFLETGKYHGEPATVWSLGIVLFVMLFWKFPTRRELNTIMNK--DIEGLSEECCDFMRCCLKIDPRERIKLERLNRHSWI 212
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: si:dkey-58b18.3 (si:dkey-58b18.3 [Source:ZFIN;Acc:ZDB-GENE-070912-563])

HSP 1 Score: 66.6254 bits (161), Expect = 3.088e-13
Identity = 46/134 (34.33%), Postives = 67/134 (50.00%), Query Frame = 1 
Query:   94 HRDIKPENIMVNKETLEVKLID------LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            HRDIK EN+++N +TLEVKLID      LED  +  Y         GT  ++ PE      Y+ + + V + G V +  L ++ P + E+ T       I   SE    F+  C+K+DP ERI+   L  H W+
Sbjct:   89 HRDIKLENLLINPDTLEVKLIDFGCGDILEDEAYTDYS--------GTAEYRPPEFLETGKYHGEPATVWSLGIVLFVMLFWKFPTRRELNTIMNK--DIEGLSEECCDFMRCCLKIDPRERIKLERLNRHSWI 212
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: pimr74 (Pim proto-oncogene, serine/threonine kinase, related 74 [Source:ZFIN;Acc:ZDB-GENE-120215-19])

HSP 1 Score: 67.0106 bits (162), Expect = 3.968e-13
Identity = 48/133 (36.09%), Postives = 66/133 (49.62%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDL--EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIE-TKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDW 474
            G  HRDIK EN+++NKETLEVKLID    D+L        C    GT  +  PE      Y+ K + V + G + Y  L    P  S+++ T +    K  LS E  +  +  C++  P +RI  G L SH W
Sbjct:  134 GVLHRDIKLENLLINKETLEVKLIDFGCGDLLKTSAYTTFC----GTEDYCPPEFRSSGRYHGKAATVWSLGVLLYELLCGEPPKHSDLDMTDERTWIKSGLSKECCQ-LVQSCLQRSPRKRIALGKLSSHRW 261
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Match: pimr73 (Pim proto-oncogene, serine/threonine kinase, related 73 [Source:ZFIN;Acc:ZDB-GENE-120215-17])

HSP 1 Score: 66.6254 bits (161), Expect = 5.191e-13
Identity = 48/133 (36.09%), Postives = 66/133 (49.62%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDL--EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIE-TKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDW 474
            G  HRDIK EN+++NKETLEVKLID    D+L        C    GT  +  PE      Y+ K + V + G + Y  L    P  S+++ T +    K  LS E  +  +  C++  P +RI  G L SH W
Sbjct:  138 GVLHRDIKLENLLINKETLEVKLIDFGCGDLLKTSAYTTFC----GTEDYCPPEFRSSGRYHGKAATVWSLGVLLYELLCGEPPKDSDLDLTDERTWIKSGLSKECCQ-LVQSCLQRSPRKRIALGKLSSHRW 265
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: b3galt5.2 (beta-1,3-galactosyltransferase 5 gene 2 [Source:Xenbase;Acc:XB-GENE-992036])

HSP 1 Score: 61.2326 bits (147), Expect = 1.395e-10
Identity = 47/170 (27.65%), Postives = 81/170 (47.65%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN +   E+   E+K+ID         D     +   TL + +PE+  +  Y+    L  + G + Y  L  +VPF+   +T +C      + KI             N+S E A+  I   + +DP++RI+   L  ++WL +  +++S NP+
Sbjct:  487 VSHMHDVGVVHRDLKPENFLFTDESDNSEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNENGYDESCDL-WSLGVILYTMLSGQVPFQCHGKTLQCTSAEDIMKKIKQGDFSCEGEAWTNVSQE-AKDLIQGLLTVDPNKRIKMSTLRYNEWLQDGSQLSS-NPL 653
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: b3galt5.2 (beta-1,3-galactosyltransferase 5 gene 2 [Source:Xenbase;Acc:XB-GENE-992036])

HSP 1 Score: 61.2326 bits (147), Expect = 1.466e-10
Identity = 47/170 (27.65%), Postives = 81/170 (47.65%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN +   E+   E+K+ID         D     +   TL + +PE+  +  Y+    L  + G + Y  L  +VPF+   +T +C      + KI             N+S E A+  I   + +DP++RI+   L  ++WL +  +++S NP+
Sbjct:  517 VSHMHDVGVVHRDLKPENFLFTDESDNSEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNENGYDESCDL-WSLGVILYTMLSGQVPFQCHGKTLQCTSAEDIMKKIKQGDFSCEGEAWTNVSQE-AKDLIQGLLTVDPNKRIKMSTLRYNEWLQDGSQLSS-NPL 683
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: b3galt5.2 (beta-1,3-galactosyltransferase 5 gene 2 [Source:Xenbase;Acc:XB-GENE-992036])

HSP 1 Score: 61.2326 bits (147), Expect = 1.484e-10
Identity = 47/170 (27.65%), Postives = 81/170 (47.65%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN +   E+   E+K+ID         D     +   TL + +PE+  +  Y+    L  + G + Y  L  +VPF+   +T +C      + KI             N+S E A+  I   + +DP++RI+   L  ++WL +  +++S NP+
Sbjct:  492 VSHMHDVGVVHRDLKPENFLFTDESDNSEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNENGYDESCDL-WSLGVILYTMLSGQVPFQCHGKTLQCTSAEDIMKKIKQGDFSCEGEAWTNVSQE-AKDLIQGLLTVDPNKRIKMSTLRYNEWLQDGSQLSS-NPL 658
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: b3galt5.2 (beta-1,3-galactosyltransferase 5 gene 2 [Source:Xenbase;Acc:XB-GENE-992036])

HSP 1 Score: 60.8474 bits (146), Expect = 1.554e-10
Identity = 47/170 (27.65%), Postives = 81/170 (47.65%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN +   E+   E+K+ID         D     +   TL + +PE+  +  Y+    L  + G + Y  L  +VPF+   +T +C      + KI             N+S E A+  I   + +DP++RI+   L  ++WL +  +++S NP+
Sbjct:  499 VSHMHDVGVVHRDLKPENFLFTDESDNSEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNENGYDESCDL-WSLGVILYTMLSGQVPFQCHGKTLQCTSAEDIMKKIKQGDFSCEGEAWTNVSQE-AKDLIQGLLTVDPNKRIKMSTLRYNEWLQDGSQLSS-NPL 665
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Match: b3galt5.2 (beta-1,3-galactosyltransferase 5 gene 2 [Source:Xenbase;Acc:XB-GENE-992036])

HSP 1 Score: 60.8474 bits (146), Expect = 1.588e-10
Identity = 47/170 (27.65%), Postives = 81/170 (47.65%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN +   E+   E+K+ID         D     +   TL + +PE+  +  Y+    L  + G + Y  L  +VPF+   +T +C      + KI             N+S E A+  I   + +DP++RI+   L  ++WL +  +++S NP+
Sbjct:  515 VSHMHDVGVVHRDLKPENFLFTDESDNSEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNENGYDESCDL-WSLGVILYTMLSGQVPFQCHGKTLQCTSAEDIMKKIKQGDFSCEGEAWTNVSQE-AKDLIQGLLTVDPNKRIKMSTLRYNEWLQDGSQLSS-NPL 681
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Rps6ka5 (ribosomal protein S6 kinase, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1920336])

HSP 1 Score: 61.6178 bits (148), Expect = 7.274e-11
Identity = 47/170 (27.65%), Postives = 80/170 (47.06%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKE--TLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN++   E   LE+K+ID         D     +   TL + +PE+     Y+    L  + G + Y  L  +VPF+S   +  C      + KI             N+S E A+  I   + +DP++R++   L  ++WL +  +++S NP+
Sbjct:  596 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDL-WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQE-AKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSS-NPL 762
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Rps6ka5 (ribosomal protein S6 kinase, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1920336])

HSP 1 Score: 61.2326 bits (147), Expect = 1.038e-10
Identity = 47/170 (27.65%), Postives = 80/170 (47.06%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKE--TLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN++   E   LE+K+ID         D     +   TL + +PE+     Y+    L  + G + Y  L  +VPF+S   +  C      + KI             N+S E A+  I   + +DP++R++   L  ++WL +  +++S NP+
Sbjct:  531 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDL-WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQE-AKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSS-NPL 697
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Smok3c (sperm motility kinase 3C [Source:MGI Symbol;Acc:MGI:3647925])

HSP 1 Score: 57.3806 bits (137), Expect = 1.581e-9
Identity = 44/141 (31.21%), Postives = 70/141 (49.65%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLID--LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKS--------EIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            G  HRD+KP+NIMV K+  +VK+ID  L   +     +   N   GT  F +PE+    PY+  +  V T G V YF +  ++PF +         I   K ++P   LS+EL R  ++  +  +P  R    +++ H W+
Sbjct:  142 GIVHRDLKPDNIMVEKDG-KVKIIDFGLSTKVKPGQKL---NLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTGKIPFDACSIKRLVKRILAGKYSIPS-RLSAEL-RDLLSLLMTANPKLRPTVAEVMVHPWV 276
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Smok3c (sperm motility kinase 3C [Source:MGI Symbol;Acc:MGI:3647925])

HSP 1 Score: 57.3806 bits (137), Expect = 1.581e-9
Identity = 44/141 (31.21%), Postives = 70/141 (49.65%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLID--LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKS--------EIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            G  HRD+KP+NIMV K+  +VK+ID  L   +     +   N   GT  F +PE+    PY+  +  V T G V YF +  ++PF +         I   K ++P   LS+EL R  ++  +  +P  R    +++ H W+
Sbjct:  142 GIVHRDLKPDNIMVEKDG-KVKIIDFGLSTKVKPGQKL---NLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTGKIPFDACSIKRLVKRILAGKYSIPS-RLSAEL-RDLLSLLMTANPKLRPTVAEVMVHPWV 276
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Match: Tssk5 (testis-specific serine kinase 5 [Source:MGI Symbol;Acc:MGI:1920792])

HSP 1 Score: 56.6102 bits (135), Expect = 2.828e-9
Identity = 41/156 (26.28%), Postives = 74/156 (47.44%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTL----GTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKI------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITS 501
            V     +G  HRD+K ENI+++ +      I L D  F  + + + NS L    G++ + +PEI     YN +Q+ + + G + +  +  ++PFK     +  NL +        LS E  R  I   ++L P ER++   + +H W+   + + S
Sbjct:  161 VAHCHNVGIVHRDLKCENILLDDQGF----IKLTDFGFANW-VGLKNSLLSTFCGSVAYTAPEILMSKKYNGEQADLWSLGIILHAMVSGKLPFKEHQPHRMLNLIRRGPIFRPGLSPE-CRDLIRGLLQLHPCERLDLQQVAAHCWMLPAEHMLS 310
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|Q5F3L1|KS6A5_CHICK (Ribosomal protein S6 kinase alpha-5 OS=Gallus gallus OX=9031 GN=RPS6KA5 PE=2 SV=1)

HSP 1 Score: 66.6254 bits (161), Expect = 9.866e-12
Identity = 49/175 (28.00%), Postives = 83/175 (47.43%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKINLS------------SELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPMAIAKSL 531
            V  M ++G  HRD+KPEN++   ET   E+K+ID         D     +   TL + +PE+F    Y+    L  + G + Y  L  +VPF+S+ ++  C      + KI               SE A+  I   + +DP++RI+   L  ++WL +  +++S NP+    +L
Sbjct:  522 VSHMHDVGVVHRDLKPENLLFTDETDNSEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELFNHNGYDESCDL-WSLGVILYTMLSGQVPFQSQDKSLTCTSALEIMKKIKKGEFSFEGEAWKNVSEEAKELIQGLLTVDPNKRIKMSSLRYNEWLQDGSQLSS-NPLMTPDNL 694
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|U4PR86|MELK_CAEEL (Maternal embryonic leucine zipper kinase OS=Caenorhabditis elegans OX=6239 GN=pig-1 PE=1 SV=1)

HSP 1 Score: 62.7734 bits (151), Expect = 2.231e-10
Identity = 43/146 (29.45%), Postives = 73/146 (50.00%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDL------EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKS---EIETKKCN---LPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNK 486
            GY HRD+KPEN+++  E L +KLID       E    D++++  C    G+  + +PE+   + Y   ++ V + G + Y  L   +PF+    +I  KK       +    S L++  +   +++ P+ RI    LL HDWL +K
Sbjct:  127 GYAHRDLKPENLLLT-EDLHLKLIDFGLCAKTEKGRIDKHNLDTC---CGSPAYAAPELIQGLQYKGNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWLNHK 268
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|O75582|KS6A5_HUMAN (Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens OX=9606 GN=RPS6KA5 PE=1 SV=1)

HSP 1 Score: 62.003 bits (149), Expect = 3.280e-10
Identity = 47/170 (27.65%), Postives = 80/170 (47.06%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKE--TLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN++   E   LE+K+ID         D     +   TL + +PE+     Y+    L  + G + Y  L  +VPF+S   +  C      + KI             N+S E A+  I   + +DP++R++   L  ++WL +  +++S NP+
Sbjct:  532 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL-WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQE-AKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSS-NPL 698
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|P34244|HSL1_YEAST (Probable serine/threonine-protein kinase HSL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HSL1 PE=1 SV=2)

HSP 1 Score: 62.003 bits (149), Expect = 4.031e-10
Identity = 42/144 (29.17%), Postives = 75/144 (52.08%), Query Frame = 1 
Query:   94 HRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIP--ICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE--------IETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKI 495
            HRD+KPEN++++K+   +K+ D         ++P  +  ++ G+  + SPEI    PY+   S V + G V +  L   +PF  +        +++ K  +P  NLSSE AR  I+  + +DP++RI   ++L H  +   D +
Sbjct:  237 HRDLKPENLLLDKKNRRIKIADFG---MAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQMPS-NLSSE-ARDLISKILVIDPEKRITTQEILKHPLIKKYDDL 375
[Close]
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Match: sp|Q8C050|KS6A5_MOUSE (Ribosomal protein S6 kinase alpha-5 OS=Mus musculus OX=10090 GN=Rps6ka5 PE=1 SV=2)

HSP 1 Score: 61.6178 bits (148), Expect = 5.088e-10
Identity = 47/170 (27.65%), Postives = 80/170 (47.06%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKE--TLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKI-------------NLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN++   E   LE+K+ID         D     +   TL + +PE+     Y+    L  + G + Y  L  +VPF+S   +  C      + KI             N+S E A+  I   + +DP++R++   L  ++WL +  +++S NP+
Sbjct:  596 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDL-WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQE-AKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSS-NPL 762
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: A0A2P1ERR9 (PIM-1-like protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 236.498 bits (602), Expect = 1.891e-75
Identity = 114/169 (67.46%), Postives = 140/169 (82.84%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYN-----KDKITSYNPMAIAKSLWNIFSNLI 555
            VY+MS+IGYYHRDIKPENIMVN+ TLE+KLIDLED+L+D+ +IP C S LGTLGFQSPE +G VPYNLKQSLV   GC+AYFC+E+   F ++IET+KC LP++ +SS+LARSFIT+CIKLDP+ERIEF DLL HDWL N     K+ I SYNPMAIA+SL  +F+ +I
Sbjct:   77 VYKMSDIGYYHRDIKPENIMVNQRTLEIKLIDLEDMLYDENEIPKCISELGTLGFQSPETYGKVPYNLKQSLVFNIGCLAYFCIEYEYAFDTKIETQKCLLPEMKVSSKLARSFITECIKLDPNERIEFDDLLFHDWLENENNVDKNNINSYNPMAIAESLREMFNKII 245
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: A0A498LLR4 (Serine threonine-kinase pim-1-like protein OS=Labeo rohita OX=84645 GN=ROHU_035267 PE=4 SV=1)

HSP 1 Score: 83.5741 bits (205), Expect = 3.883e-15
Identity = 52/137 (37.96%), Postives = 75/137 (54.74%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLID--LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNL-PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNK 486
            G +HRDIK  N++VN ET+EVKLID  + D+L     I       GT  F  PE F    Y  KQ+ V + G + +  +  R P+ S+I+    N+  + + S E  R FI  C+K DP++R+   ++LSHDW   K
Sbjct:  322 GVFHRDIKMSNLLVNTETMEVKLIDFGVGDLLKSSPYIFFS----GTANFCPPEYFTKGEYLGKQATVWSLGVLLFNMMTNRYPYSSDIKLMDANVWTEPDFSDECCR-FIRGCLKSDPEQRVLLEEMLSHDWFKQK 453
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: A0A2D0PS18 (spindle assembly checkpoint kinase-like OS=Ictalurus punctatus OX=7998 GN=LOC108256152 PE=4 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 2.606e-14
Identity = 46/138 (33.33%), Postives = 76/138 (55.07%), Query Frame = 1 
Query:   79 EIGYYHRDIKPENIMVNKETLEVKLID------LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDW 474
            E G +HRDIKPEN+++N +T++VKLID      + D  + +++        GTL + SPE   D  Y    + V + G + Y+ +   +PFK+  E     +P  +  S   ++ IT C++ +PD R+   ++LSHDW
Sbjct:  466 ERGVFHRDIKPENLLINTDTMQVKLIDFGCGELMYDFTYTKFE--------GTLIYASPEWVRDREYMGGPATVWSLGILLYYMVCCDLPFKNNKEISDAPVPLHHYLSGDCQALITGCLEKNPDYRMTLENILSHDW 595
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: A0A556TUR0 (Serine/threonine-protein kinase pim-3 OS=Bagarius yarrelli OX=175774 GN=Baya_5442 PE=4 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 3.423e-14
Identity = 47/133 (35.34%), Postives = 72/133 (54.14%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDL--EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            G +HRDIKPEN+++N ETLEVKLID    D++ D++     +S  GT  +  PE   +  Y    + V + G   +  +   +PF +E E     LP +N  SE   S I+ C+  DP++R    ++L+H W 
Sbjct:  273 GVFHRDIKPENLLINPETLEVKLIDFGCGDLMKDEF----YSSYSGTPAYTPPEWIVEKKYLAVPATVWSLGVFLFEMVSGDLPFNNEEEISAACLPLVNGVSEECYSLISWCLTKDPNQRPSLDEILNHSWF 401
[Close]
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Match: A0A498NAM7 (Serine threonine-kinase pim-1-like protein OS=Labeo rohita OX=84645 GN=ROHU_018992 PE=4 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 3.931e-14
Identity = 52/145 (35.86%), Postives = 79/145 (54.48%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTL---GTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNL-PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYN 507
            G +HRDIK  N++VN ET+EVKLID     F   D+   +  +   GT  F  PE F    Y+ KQ+ V + G V +  +  R P+ S+I+    N+  + + S E  R FI  C+K +P++R+    +LSHDW   K ++T + 
Sbjct:  322 GVFHRDIKMSNLLVNTETMEVKLID-----FGVGDLLKSSPYIFFSGTANFCPPEYFTKGEYHGKQATVWSLGVVLFNMMTNRYPYSSDIKLMDANVWTEPDFSDECCR-FIHGCLKSNPEQRVRLEKMLSHDWF--KSQVTHFT 458
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000040711.1 (serine/threonine-protein kinase pim-1-like [Source:NCBI gene;Acc:103035777])

HSP 1 Score: 62.3882 bits (150), Expect = 1.820e-11
Identity = 46/135 (34.07%), Postives = 65/135 (48.15%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDLE-DVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLP-KINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYN 483
            G  HRDIKPEN ++N  TLE+KLID        +Y     N   GT  +  PE+F    Y+ K + V + G   +  L    PFK+  +     L  K  LS E     I  C++  P +R    ++L HDWL++
Sbjct:  178 GVLHRDIKPENFLINPNTLELKLIDFGCGDWLKKYGY---NLYSGTFEYVPPELFRKRRYHSKTATVWSLGIFLFRMLCGSCPFKNAKDIVAGLLYFKDGLSDECC-DLIRQCLQYIPAKRPTIREILKHDWLHD 308
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000007966.2 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000825.1:13259:19776:-1 gene:ENSAMXG00000007734.2 transcript:ENSAMXT00000007966.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.003 bits (149), Expect = 2.776e-11
Identity = 46/151 (30.46%), Postives = 72/151 (47.68%), Query Frame = 1 
Query:   94 HRDIKPENIMVNKETLEVKLIDL---EDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLP-KINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNK--DKITSYNPMAIAKS 528
            HRDIKP+N ++N ET  VKLID    + +  D+Y     +S +GT  +  PE      Y    + V + G   Y  +   +PFKS  E  +  L  +  LS E     I  C++ DP+ R     +  H W  +   D+ T++N + +A +
Sbjct:  169 HRDIKPDNFLINMETAVVKLIDFGCGDWIRDDEY-----HSVIGTWLYHPPESILWRRYRATPATVWSLGVTLYRMVMGHMPFKSIQEIVQGRLEFRDGLSKECC-DLIRWCLQFDPNSRPSLLKMRKHQWFKSTFPDRHTNHNILQLAST 313
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000043607.1 (pep primary_assembly:Astyanax_mexicanus-2.0:20:33833945:33836628:-1 gene:ENSAMXG00000042906.1 transcript:ENSAMXT00000043607.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 61.6178 bits (148), Expect = 5.377e-11
Identity = 47/152 (30.92%), Postives = 74/152 (48.68%), Query Frame = 1 
Query:   73 MSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLS-------SELARSFITDCIKLDPDERIEFGDLLSHDWLYN--KDKITS 501
            M E    HRD+K +NI+V  +   VK+ D       +    +CNS +GTL + SPE+  +  Y+ K+S V + G V Y  +   +P  S+ + ++   PK+  +        E  R+ I D ++LDP  R     +  H WL +  KD  TS
Sbjct:  152 MHEQDIVHRDLKCDNILVTADG-NVKIADFG---LSRVTKGLCNSMVGTLWYVSPEVIREKKYDAKKSDVWSLGIVLYALVTGELPSYSD-DLEQIASPKLPYTFPDDVEVEESCRALILDMLQLDPSARPTVKKVSEHPWLQSDVKDTPTS 298
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000009626.2 (serine/threonine-protein kinase pim-1-like [Source:NCBI gene;Acc:111194017])

HSP 1 Score: 61.2326 bits (147), Expect = 6.661e-11
Identity = 45/135 (33.33%), Postives = 66/135 (48.89%), Query Frame = 1 
Query:   79 EIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIET-KKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLY 480
            E G +HRDIKP N ++N +TLE+KLID      D   +   NS  GT  +  PE      Y+ K + V + G + Y  +    PFK+  E  +     +  LS E     I   +  +P++R  FG +L+H W Y
Sbjct:  227 ERGVFHRDIKPGNFLINPQTLELKLIDFG--CADWVKLEGNNSYAGTRVYCPPEYLIKRRYHAKPATVWSLGVMLYRMVCGCQPFKNNQEICQGLTDIRGGLSYECC-DLIRWLLWHNPNKRPCFGQILNHSWFY 358
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000032798.1 (pep primary_assembly:Astyanax_mexicanus-2.0:9:3419416:3422603:-1 gene:ENSAMXG00000030538.1 transcript:ENSAMXT00000032798.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.151 bits (139), Expect = 2.424e-10
Identity = 42/124 (33.87%), Postives = 63/124 (50.81%), Query Frame = 1 
Query:   73 MSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNL-PKINLSSELARSFITDCIKLDPDER 441
            M E    HRD+K +NI+V  E   VK+ D       +    +CN+  GTLG+ SPE+     Y+ K+S V + G V Y  +  ++P  S  + +  NL P  +   E  R+ I D ++LDP  R
Sbjct:   62 MHEQDIVHRDLKCDNILVT-EDCNVKITDFGLSRVTKGYPELCNTFCGTLGYISPEVHNREAYDGKKSDVWSLGIVLYVMVTGKLPSCSRKKKELANLFP--DYVEESCRALILDMLQLDPSAR 182
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: camk2a (calcium/calmodulin-dependent protein kinase II alpha [Source:ZFIN;Acc:ZDB-GENE-051113-72])

HSP 1 Score: 58.151 bits (139), Expect = 1.442e-10
Identity = 42/158 (26.58%), Postives = 71/158 (44.94%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETK-----KCNL-----PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITS 501
            V    ++G  HRD+KPEN+++  +T    VKL D    +  Q +        GT G+ SPE+    PY  K   +   G + Y  L    PF  E + +     K        P+ +  +  A+S I   + ++P +RI   + L+H W++ +  + S
Sbjct:   32 VLHCHQLGIVHRDLKPENLLLASKTKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYG-KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKSLINQMLTINPAKRITASEALTHPWIFQRSTVAS 188
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: rps6ka5 (ribosomal protein S6 kinase, polypeptide 5 [Source:ZFIN;Acc:ZDB-GENE-130530-693])

HSP 1 Score: 54.299 bits (129), Expect = 3.298e-9
Identity = 42/167 (25.15%), Postives = 76/167 (45.51%), Query Frame = 1 
Query:   73 MSEIGYYHRDIKPENIMV--NKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCN-----LPKINLS------------SELARSFITD-CIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            M + G  HRD+KPEN++   + E   +K+ID         D     +   TL + +PE+     Y+ +   V + G + Y  L  +VPF+S  +   C+     + KI               S+ A+  I    + +DP +R++   L  ++WL +  +++S NP+
Sbjct:  220 MHDTGVVHRDLKPENLLFADDTEGAAIKVIDFGFARLKPQDNAPLKTPCFTLQYAAPELLQHAGYD-ESCDVWSLGVILYTMLSGQVPFQSHGQPMTCSSATDIMRKIKEGDFSFEGEAWQNVSQAAKDLIQGRLLTVDPSKRVKMSGLRYNEWLQDGSQLSS-NPL 384
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008748.1 (pep scaffold:Pmarinus_7.0:GL476577:591:63029:-1 gene:ENSPMAG00000007907.1 transcript:ENSPMAT00000008748.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 53.5286 bits (127), Expect = 4.840e-9
Identity = 42/158 (26.58%), Postives = 68/158 (43.04%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKET--LEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETK-----KCNL-----PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITS 501
            V+   + G  HRD+KPEN+++  +     VKL D    +  Q D        GT G+ SPE+    PY  K   +   G + Y  L    PF  E + K     K        P+ +  +  A++ I   + ++P +RI   + L H W+  +  + S
Sbjct:  124 VHHCHQHGIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYG-KPVDMWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTAEAKNLINQMLTINPAKRITAAEALKHPWICQRSTVAS 280
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001750.1 (pep scaffold:Pmarinus_7.0:GL481695:1137:12922:1 gene:ENSPMAG00000001576.1 transcript:ENSPMAT00000001750.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 51.2174 bits (121), Expect = 3.737e-8
Identity = 40/141 (28.37%), Postives = 66/141 (46.81%), Query Frame = 1 
Query:   94 HRDIKPENIMVNKETLEVKLID--LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINL--------------SSELARSFITDCIKLDPDERIEFGDLLSH 468
            HRD+K  NI+++K    VK+ D  +  +L  +       + +GT  + SPE+    PYN ++S +   GC+ Y     +  F++E      NLP + L              S EL R  +   + LDP +R +  ++LSH
Sbjct:   42 HRDLKTHNILLDKRQTVVKIGDFGISKILSSKSK---AYTVVGTPCYISPELCEGKPYN-QKSDIWALGCILYELASLKRAFEAE------NLPALVLKIMSGNFAPVSDRYSGEL-RQLVVSLLNLDPSKRPQLSEVLSH 171
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Match: STK36 (serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209])

HSP 1 Score: 50.447 bits (119), Expect = 8.356e-8
Identity = 42/142 (29.58%), Postives = 65/142 (45.77%), Query Frame = 1 
Query:   94 HRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE--------IETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKI 495
            HRD+KP+NI++ K  + VKL D         +  +  S  GT  + SPE+  + PY+    L  + GC+ Y       PF +         I       PK N+SSE  R+F+   +  +P  R+ +  LL H ++  K  I
Sbjct:  123 HRDMKPQNILLGKGGV-VKLCDFGFARAMSINTLVLTSIKGTPLYMSPELVEEKPYDHTADL-WSMGCILYELFVGTPPFYTNSIFQLVSLIIKDPVKWPK-NMSSEF-RNFLQGLLTKEPKLRLSWPALLHHPFVAGKSSI 260
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: HSL1 (Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; autophosphorylation enhances interactions with Hsl7p [Source:SGD;Acc:S000001584])

HSP 1 Score: 62.003 bits (149), Expect = 5.806e-12
Identity = 42/144 (29.17%), Postives = 75/144 (52.08%), Query Frame = 1 
Query:   94 HRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIP--ICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE--------IETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKI 495
            HRD+KPEN++++K+   +K+ D         ++P  +  ++ G+  + SPEI    PY+   S V + G V +  L   +PF  +        +++ K  +P  NLSSE AR  I+  + +DP++RI   ++L H  +   D +
Sbjct:  237 HRDLKPENLLLDKKNRRIKIADFG---MAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQMPS-NLSSE-ARDLISKILVIDPEKRITTQEILKHPLIKKYDDL 375
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: KCC4 (Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication [Source:SGD;Acc:S000000529])

HSP 1 Score: 58.5362 bits (140), Expect = 8.082e-11
Identity = 39/142 (27.46%), Postives = 68/142 (47.89%), Query Frame = 1 
Query:   82 IGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE----------IETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            +G  HRD+KPEN++++     +K+ D       Q D  +  ++ G+  + +PEI   +PY    S V + G + +  L  R+PF  E          ++  +  +P     S  A+  I   + +DP +RI+  D+LSH  L
Sbjct:  146 LGIVHRDLKPENLLLD-SFYNIKIADFGMAAL-QTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLL 285
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086])

HSP 1 Score: 56.225 bits (134), Expect = 4.910e-10
Identity = 43/135 (31.85%), Postives = 70/135 (51.85%), Query Frame = 1 
Query:   94 HRDIKPENIMVNKETLEVKLIDLE-DVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE---IETKKCNLPKINLSSELA---RSFITDCIKLDPDERIEFGDLLSHDWL 477
            HRD+K ENIM++    E+K+ID     +FD Y   + ++  G+L F +PE+    PY   +  + +FG V Y  +  +VPF  E   I  +K    K++  S L+    S +T  I +DP  R    +++ H W+
Sbjct:  246 HRDLKIENIMISSSG-EIKIIDFGLSNIFD-YRKQL-HTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWM 377
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: GIN4 (Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication [Source:SGD;Acc:S000002915])

HSP 1 Score: 55.8398 bits (133), Expect = 7.019e-10
Identity = 36/142 (25.35%), Postives = 69/142 (48.59%), Query Frame = 1 
Query:   82 IGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE----------IETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            +G  HRD+KPEN++++ +   +K+ D       + +  +  ++ G+  + +PEI   +PY    S V + G + +  L  R+PF  E          ++  +  +P  +  S  A+  I   + +DP+ RI+  D+L H  L
Sbjct:  150 LGIVHRDLKPENLLLDHK-YNIKIADFGMAAL-ETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTVDPERRIKTRDILKHPLL 289
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529])

HSP 1 Score: 55.4546 bits (132), Expect = 9.315e-10
Identity = 42/137 (30.66%), Postives = 70/137 (51.09%), Query Frame = 1 
Query:   94 HRDIKPENIMVNKETLEVKLIDLEDVLFDQYDI-PICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE--------IETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            HRD+K ENIM++  + E+K+ID    L + YD     ++  G+L F +PE+    PY   +  V +FG V +  +  +VPF  E        I+  K   P+ +LS E+  S ++  + +DP  R     ++ H W+
Sbjct:  267 HRDLKIENIMISDSS-EIKIIDFG--LSNIYDSRKQLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQ-HLSIEVI-SLLSKMLVVDPKRRATLKQVVEHHWM 398
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO46861 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNH5])

HSP 1 Score: 62.7734 bits (151), Expect = 4.001e-12
Identity = 44/150 (29.33%), Postives = 71/150 (47.33%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLID------LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPMA 516
            G +HRDIK EN++++ +T +VKL D      LE+ L+  Y+        GT  +  PE F    Y+ +   V + G + +  L   VPF ++IE  +  L      S+ A+S +   +   P  R    ++L H WL +     S +P A
Sbjct:  109 GVFHRDIKDENLLLDTKTGQVKLFDFGSGTVLENTLYTDYE--------GTRAYCPPEWFRFHRYHARPCTVWSLGILLFNMLSGDVPFANQIEIVRGELNFAENVSKEAQSLVRWLLAKHPSYRPTLENILKHPWLGSVKYRRSKSPQA 250
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO44613 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVB0])

HSP 1 Score: 54.6842 bits (130), Expect = 4.353e-9
Identity = 40/160 (25.00%), Postives = 73/160 (45.62%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMV----NKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYN-LKQSLVC-TFGCVAYFCLEFRVPFKSEIE---------TKKCNLPKINLS--SELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            G  HRD+KPENI++    N+  L++    +  ++ +Q    +  +  GT  + +PE+          +++ C + GC+ Y CL    PF  E+E           K   PK +    S+ A   I   + +DP +R+    +L H W+ +++ I   N +
Sbjct:  312 GITHRDLKPENILLCSDKNETLLKITDFGVSKMVGEQ---SLMKTLCGTPSYLAPEVLRSAGLGGYSKAVDCWSLGCMLYICLGGYAPFSDEVEPYDVNKLILAGKYTFPKQHWKCVSDEAIDLIKKLLTVDPSKRLTIQQVLEHPWIKDEEVIEKANRL 468
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO49690 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG02])

HSP 1 Score: 54.299 bits (129), Expect = 4.805e-9
Identity = 44/144 (30.56%), Postives = 67/144 (46.53%), Query Frame = 1 
Query:   73 MSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE---------IETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            M E    HRD+K +NI + K  + +K+ DL      +    +  + +GT  + SPE+F + PYN K S V   GC  Y     R  F ++         ++ K   LPK   S++L  S I   +  DPD+R     LL H ++
Sbjct:  122 MHEKHILHRDLKTQNIFLTKSKI-IKVGDLGIARVLESSSDMATTLIGTPYYMSPELFSNKPYNHK-SDVWALGCCLYEMCTLRHAFNAKDMSSLVYKILKGKTPPLPK-QYSTDLC-SIIKSMLDQDPDKRPSASRLLRHPYI 261
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO49547 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGL1])

HSP 1 Score: 53.1434 bits (126), Expect = 8.356e-9
Identity = 37/145 (25.52%), Postives = 63/145 (43.45%), Query Frame = 1 
Query:   73 MSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE--------IETKKCNLPKINLSS--ELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            + E+   H DI+P NIMV     +VKLID  +    +         +G   F +PE+    P N+   +  + G V Y  L  ++PF  +        ++  +C        S  + ++ FI   +   P +R+E    L+H+WL
Sbjct:  102 LHELNIVHLDIRPANIMVQGS--DVKLIDFGNARKLKSRHGEVGVVVGNPSFTAPEVLSFEPVNMAADM-WSVGIVTYALLSGQLPFPGDNDDAVEEAVKQARCTFVGRAFRSLTDHSKGFIEKLLYKIPSKRLEVAGALTHEWL 243
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Match: EDO30537 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0H5])

HSP 1 Score: 53.9138 bits (128), Expect = 8.721e-9
Identity = 40/148 (27.03%), Postives = 68/148 (45.95%), Query Frame = 1 
Query:   94 HRDIKPENIMV--NKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSE------IETKKCNL----PKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITS 501
            HRD+KPEN+++   ++   VKL D    +  + +        GT G+ SPE+    PY  K   +   G + Y  L    PF  E       + K  N     P+ +  ++ A+  I   + +D  +RI  G+ L H W+ N++++ S
Sbjct:  133 HRDLKPENLLLASKEKNAAVKLADFGLAIEVEIEKTGWYGFAGTPGYLSPEVLKKEPYG-KPVDLWACGVILYILLVGYPPFWDEDQHKLYAQIKTGNYDYPSPEWDTVTDEAKDLINMMLTVDQSKRIGAGEALKHPWIVNRERVAS 279
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: pim1 (serine/threonine-protein kinase pim-1 [Source:NCBI gene;Acc:101157054])

HSP 1 Score: 60.4622 bits (145), Expect = 1.097e-10
Identity = 42/140 (30.00%), Postives = 71/140 (50.71%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLID------LEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIE-TKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYN 483
            G  HRDIK ENI+++  T E+KLID      L+D ++  +D        GT  +  PE      Y  + + V + G + Y  +   +PF+ + E T+   L +  +S+E  +  I  C+ L P +R  F D+++H W+ +
Sbjct:  158 GVVHRDIKDENILIDLRTGEMKLIDFGSGALLKDTIYTDFD--------GTRVYSPPEWIKYHRYQGRSATVWSLGILLYDMVCGDIPFEHDEEITRGQVLFRRRISTE-CQHLIKWCLSLRPTDRPSFEDVINHSWMQS 288
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: camk1gb (calcium/calmodulin-dependent protein kinase type 1D [Source:NCBI gene;Acc:101164726])

HSP 1 Score: 58.5362 bits (140), Expect = 5.871e-10
Identity = 42/145 (28.97%), Postives = 68/145 (46.90%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVC-TFGCVAYFCLEFRVPFKSEIETK----------KCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNK 486
            G  HRD+KPENI+   +  + K++  +  L    D  I ++  GT G+ +PE+    PY+  +++ C + G + Y  L    PF  E ETK          + + P  +  SE A+ FI + ++  P  R      L H W+  K
Sbjct:  135 GIVHRDLKPENILYYSQDEDSKIMISDFGLSKMTDTGIMSTACGTPGYVAPEVLAQKPYS--KAVDCWSIGVITYILLCGYPPFYEESETKLFSKIMKAQYEFDSPFWDDISESAKDFIRNMMQKTPSMRYSTEQALRHPWIIGK 277
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: ENSORLT00000043568.1 (pep primary_assembly:ASM223467v1:21:28201084:28203513:1 gene:ENSORLG00000028900.1 transcript:ENSORLT00000043568.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.225 bits (134), Expect = 2.798e-9
Identity = 39/140 (27.86%), Postives = 65/140 (46.43%), Query Frame = 1 
Query:   94 HRDIKPENIMV--NKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKC-NLPKINL---------SSELARSFITDCIKLDPDERIEFGDLLSHDWL 477
            H D+KPENIMV  +  +  +KL+DL D +         +  LG   F +PE+    P +L   +  +   +AY  L    PF  E   + C N+ +++           S+ AR F++  ++ DP +R+     L H W+
Sbjct:  108 HLDLKPENIMVDLHGPSPSIKLVDLGDAVHLSAHRKYIHLLLGNPEFAAPELIQGSPVSLATDM-WSVAVLAYVMLSGVSPFLDESPEETCINICRLDFCFPDEYFSGVSQAARDFVSSGLQQDPRKRLSATSCLQHPWV 246
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: ENSORLT00000041570.1 (pep primary_assembly:ASM223467v1:10:18938984:18940525:-1 gene:ENSORLG00000023590.1 transcript:ENSORLT00000041570.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.225 bits (134), Expect = 3.777e-9
Identity = 40/134 (29.85%), Postives = 62/134 (46.27%), Query Frame = 1 
Query:   85 GYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNK 486
            G  H D+K EN++V+  TLE+KLID     F + D  + +   GT  +  PE      Y    S V + G + Y  +   +PF ++ E     L      SE   + I  C+   P+ER    D+L+H W+  +
Sbjct:  165 GVVHMDVKDENLLVDLTTLELKLIDFGSAEFLEPD-KVYDMFHGTAAYGPPERLTQGCYKALPSEVWSLGILLYDMVHGDIPFGNDRELLLGELRFEKDLSEDCVALIKWCLSRTPEERPMLKDILAHPWMLKR 297
[Close]
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Match: rps6ka5 (ribosomal protein S6 kinase alpha-5 [Source:NCBI gene;Acc:101166594])

HSP 1 Score: 56.225 bits (134), Expect = 4.356e-9
Identity = 44/169 (26.04%), Postives = 77/169 (45.56%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKETLE--VKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIET----------KKCNLPKINLS-------SELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPM 513
            V  M ++G  HRD+KPEN++   E+    +K+ID         D  +  +   TL + +PEI     Y+    L  + G + Y  L  +VPF+ +  T          KK      +         S+ A+  I + + +DP++RI+   L  + WL +  +++S NP+
Sbjct:  498 VSHMHDVGVVHRDLKPENLLFTDESENSGIKIIDFGFARLKPPDQQLLKTPCFTLQYAAPEILKYDGYDESCDL-WSLGVILYTMLSGQVPFQCQEPTLTHTSAEEIMKKIKQGDFSFEGEAWRNVSQQAKDLIQELLTVDPNKRIKMCGLRYNAWLQDDSQLSS-NPL 664
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000032312.1 (SMESG000032312.1)

HSP 1 Score: 354.755 bits (909), Expect = 6.527e-125
Identity = 186/187 (99.47%), Postives = 186/187 (99.47%), Query Frame = 1 
Query:    1 FTMAFPIEXXXXXXXXXXXXXVYEMSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPMAIAKSLWNIFSNLIKS 561
            FTMAFPIEKPIKTIIKNLIIIVYEMSEIGYYHRDIKPENIMVNKETLEVKLIDLED LFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPMAIAKSLWNIFSNLIKS
Sbjct:  110 FTMAFPIEKPIKTIIKNLIIIVYEMSEIGYYHRDIKPENIMVNKETLEVKLIDLEDALFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPMAIAKSLWNIFSNLIKS 296
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000061880.1 (SMESG000061880.1)

HSP 1 Score: 315.079 bits (806), Expect = 3.155e-109
Identity = 165/187 (88.24%), Postives = 175/187 (93.58%), Query Frame = 1 
Query:    1 FTMAFPIEXXXXXXXXXXXXXVYEMSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPMAIAKSLWNIFSNLIKS 561
            +TM FP E PIKTIIKNLIIIVY+MSEIGYYHRDIKP+NIMVN+ETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVC  GCVAYFCLEF+ PF S+IETKKCNLPKINLSS+LARSFITDCIK DPDERIEFGDLL H+WL N+DKITSYNPMAIAKSLWN FSN+I S
Sbjct:  110 YTMQFPYESPIKTIIKNLIIIVYKMSEIGYYHRDIKPKNIMVNEETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCNIGCVAYFCLEFQFPFNSKIETKKCNLPKINLSSDLARSFITDCIKPDPDERIEFGDLLFHNWLDNEDKITSYNPMAIAKSLWNFFSNIITS 296
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000000218.1 (SMESG000000218.1)

HSP 1 Score: 268.855 bits (686), Expect = 7.247e-91
Identity = 133/185 (71.89%), Postives = 159/185 (85.95%), Query Frame = 1 
Query:    1 FTMAFPIEXXXXXXXXXXXXXVYEMSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYNKDKITSYNPMAIAKSLWNIFSNLI 555
            FTM F  EK IK I+ NLI+IVYEMS++GYYHRDIKPENIM+N+ET EVKLIDLEDVL++  D+PICNSTLGT+G+QSPEIFGDVPYNLKQSLV   GCVAYFCLEF+ PF +E ET+KC LPK+ +SSELA+SFI +CIKLDPDERIEFG+ LSH WL  +++  SYNP+AIAKSLW IF+ ++
Sbjct:  129 FTMRFADEKLIKIIMINLILIVYEMSDLGYYHRDIKPENIMINRETFEVKLIDLEDVLYNIDDMPICNSTLGTIGYQSPEIFGDVPYNLKQSLVFNIGCVAYFCLEFQFPFDTEAETRKCCLPKMKVSSELAQSFIANCIKLDPDERIEFGEFLSHQWLAKENRTKSYNPVAIAKSLWGIFNKMV 313
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000061809.1 (SMESG000061809.1)

HSP 1 Score: 241.891 bits (616), Expect = 2.372e-80
Identity = 116/169 (68.64%), Postives = 142/169 (84.02%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYN-----KDKITSYNPMAIAKSLWNIFSNLI 555
            VY+MS+IGYYHRDIKPENIMVN++TLE+KLIDLED+L+D+ +IPIC S LGTLGFQSPE +G VPYNLKQSLV   GC+AYFC+E+   F ++IET+KC LP++ +SS+LARSFIT+CIKLDPDERIEF DLL HDWL N     K+ I SYNPMAIA+SL  +F+ +I
Sbjct:  131 VYKMSDIGYYHRDIKPENIMVNQKTLEIKLIDLEDMLYDENEIPICISELGTLGFQSPETYGKVPYNLKQSLVFNIGCLAYFCIEYEYAFDTKIETQKCLLPEMKVSSKLARSFITECIKLDPDERIEFDDLLFHDWLENENNVDKNNINSYNPMAIAESLGEMFNKII 299
[Close]
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Match: SMESG000061808.1 (SMESG000061808.1)

HSP 1 Score: 241.891 bits (616), Expect = 2.372e-80
Identity = 116/169 (68.64%), Postives = 142/169 (84.02%), Query Frame = 1 
Query:   64 VYEMSEIGYYHRDIKPENIMVNKETLEVKLIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCVAYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEFGDLLSHDWLYN-----KDKITSYNPMAIAKSLWNIFSNLI 555
            VY+MS+IGYYHRDIKPENIMVN++TLE+KLIDLED+L+D+ +IPIC S LGTLGFQSPE +G VPYNLKQSLV   GC+AYFC+E+   F ++IET+KC LP++ +SS+LARSFIT+CIKLDPDERIEF DLL HDWL N     K+ I SYNPMAIA+SL  +F+ +I
Sbjct:  131 VYKMSDIGYYHRDIKPENIMVNQKTLEIKLIDLEDMLYDENEIPICISELGTLGFQSPETYGKVPYNLKQSLVFNIGCLAYFCIEYEYAFDTKIETQKCLLPEMKVSSKLARSFITECIKLDPDERIEFDDLLFHDWLENENNVDKNNINSYNPMAIAESLGEMFNKII 299
The following BLAST results are available for this feature:
BLAST of Serine/threonine-protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RPS6KA56.830e-1127.65ribosomal protein S6 kinase A5 [Source:HGNC Symbol... [more]
RPS6KA56.952e-1127.65ribosomal protein S6 kinase A5 [Source:HGNC Symbol... [more]
CAMK1G4.805e-929.05calcium/calmodulin dependent protein kinase IG [So... [more]
PIM35.076e-927.66Pim-3 proto-oncogene, serine/threonine kinase [Sou... [more]
CAMK1G5.918e-929.05calcium/calmodulin dependent protein kinase IG [So... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pig-11.535e-1129.45Maternal embryonic leucine zipper kinase [Source:... [more]
pig-11.754e-1129.45Maternal embryonic leucine zipper kinase [Source:... [more]
pig-11.888e-1129.45Maternal embryonic leucine zipper kinase [Source:... [more]
pig-11.926e-1129.45Maternal embryonic leucine zipper kinase [Source:... [more]
cmk-14.134e-1126.67Calcium/calmodulin-dependent protein kinase type 1... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CaMKII2.847e-926.49gene:FBgn0264607 transcript:FBtr0333673[more]
CaMKII3.361e-926.49gene:FBgn0264607 transcript:FBtr0300377[more]
CaMKII3.361e-926.49gene:FBgn0264607 transcript:FBtr0089217[more]
CaMKII3.361e-926.49gene:FBgn0264607 transcript:FBtr0089218[more]
CaMKII3.391e-926.49gene:FBgn0264607 transcript:FBtr0333675[more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pimr721.912e-1336.09Pim proto-oncogene, serine/threonine kinase, relat... [more]
si:dkey-58b18.62.733e-1334.33si:dkey-58b18.6 [Source:ZFIN;Acc:ZDB-GENE-070912-5... [more]
si:dkey-58b18.33.088e-1334.33si:dkey-58b18.3 [Source:ZFIN;Acc:ZDB-GENE-070912-5... [more]
pimr743.968e-1336.09Pim proto-oncogene, serine/threonine kinase, relat... [more]
pimr735.191e-1336.09Pim proto-oncogene, serine/threonine kinase, relat... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
b3galt5.21.395e-1027.65beta-1,3-galactosyltransferase 5 gene 2 [Source:Xe... [more]
b3galt5.21.466e-1027.65beta-1,3-galactosyltransferase 5 gene 2 [Source:Xe... [more]
b3galt5.21.484e-1027.65beta-1,3-galactosyltransferase 5 gene 2 [Source:Xe... [more]
b3galt5.21.554e-1027.65beta-1,3-galactosyltransferase 5 gene 2 [Source:Xe... [more]
b3galt5.21.588e-1027.65beta-1,3-galactosyltransferase 5 gene 2 [Source:Xe... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Rps6ka57.274e-1127.65ribosomal protein S6 kinase, polypeptide 5 [Source... [more]
Rps6ka51.038e-1027.65ribosomal protein S6 kinase, polypeptide 5 [Source... [more]
Smok3c1.581e-931.21sperm motility kinase 3C [Source:MGI Symbol;Acc:MG... [more]
Smok3c1.581e-931.21sperm motility kinase 3C [Source:MGI Symbol;Acc:MG... [more]
Tssk52.828e-926.28testis-specific serine kinase 5 [Source:MGI Symbol... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5F3L1|KS6A5_CHICK9.866e-1228.00Ribosomal protein S6 kinase alpha-5 OS=Gallus gall... [more]
sp|U4PR86|MELK_CAEEL2.231e-1029.45Maternal embryonic leucine zipper kinase OS=Caenor... [more]
sp|O75582|KS6A5_HUMAN3.280e-1027.65Ribosomal protein S6 kinase alpha-5 OS=Homo sapien... [more]
sp|P34244|HSL1_YEAST4.031e-1029.17Probable serine/threonine-protein kinase HSL1 OS=S... [more]
sp|Q8C050|KS6A5_MOUSE5.088e-1027.65Ribosomal protein S6 kinase alpha-5 OS=Mus musculu... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2P1ERR91.891e-7567.46PIM-1-like protein OS=Schmidtea mediterranea OX=79... [more]
A0A498LLR43.883e-1537.96Serine threonine-kinase pim-1-like protein OS=Labe... [more]
A0A2D0PS182.606e-1433.33spindle assembly checkpoint kinase-like OS=Ictalur... [more]
A0A556TUR03.423e-1435.34Serine/threonine-protein kinase pim-3 OS=Bagarius ... [more]
A0A498NAM73.931e-1435.86Serine threonine-kinase pim-1-like protein OS=Labe... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSAMXT00000040711.11.820e-1134.07serine/threonine-protein kinase pim-1-like [Source... [more]
ENSAMXT00000007966.22.776e-1130.46pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000043607.15.377e-1130.92pep primary_assembly:Astyanax_mexicanus-2.0:20:338... [more]
ENSAMXT00000009626.26.661e-1133.33serine/threonine-protein kinase pim-1-like [Source... [more]
ENSAMXT00000032798.12.424e-1033.87pep primary_assembly:Astyanax_mexicanus-2.0:9:3419... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
camk2a1.442e-1026.58calcium/calmodulin-dependent protein kinase II alp... [more]
rps6ka53.298e-925.15ribosomal protein S6 kinase, polypeptide 5 [Source... [more]
ENSPMAT00000008748.14.840e-926.58pep scaffold:Pmarinus_7.0:GL476577:591:63029:-1 ge... [more]
ENSPMAT00000001750.13.737e-828.37pep scaffold:Pmarinus_7.0:GL481695:1137:12922:1 ge... [more]
STK368.356e-829.58serine/threonine kinase 36 [Source:HGNC Symbol;Acc... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
HSL15.806e-1229.17Nim1p-related protein kinase; septin-binding kinas... [more]
KCC48.082e-1127.46Protein kinase of the bud neck involved in the sep... [more]
KIN24.910e-1031.85Serine/threonine protein kinase involved in regula... [more]
GIN47.019e-1025.35Protein kinase involved in bud growth and assembly... [more]
KIN19.315e-1030.66Serine/threonine protein kinase involved in regula... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO468614.001e-1229.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO446134.353e-925.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO496904.805e-930.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO495478.356e-925.52Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO305378.721e-927.03Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pim11.097e-1030.00serine/threonine-protein kinase pim-1 [Source:NCBI... [more]
camk1gb5.871e-1028.97calcium/calmodulin-dependent protein kinase type 1... [more]
ENSORLT00000043568.12.798e-927.86pep primary_assembly:ASM223467v1:21:28201084:28203... [more]
ENSORLT00000041570.13.777e-929.85pep primary_assembly:ASM223467v1:10:18938984:18940... [more]
rps6ka54.356e-926.04ribosomal protein S6 kinase alpha-5 [Source:NCBI g... [more]
back to top
BLAST of Serine/threonine-protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000032312.16.527e-12599.47SMESG000032312.1[more]
SMESG000061880.13.155e-10988.24SMESG000061880.1[more]
SMESG000000218.17.247e-9171.89SMESG000000218.1[more]
SMESG000061809.12.372e-8068.64SMESG000061809.1[more]
SMESG000061808.12.372e-8068.64SMESG000061808.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008746 ID=SMED30008746|Name=Serine/threonine-protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=599bp
TTTACAATGGCATTTCCTATTGAAAAACCAATCAAAACTATAATAAAAAA
TTTAATTATAATTGTATATGAAATGTCAGAAATCGGATATTATCATCGAG
ATATCAAACCAGAAAATATTATGGTTAATAAAGAAACGCTTGAAGTGAAA
CTTATTGATTTAGAAGATGTACTTTTTGATCAATATGATATTCCGATTTG
TAATTCAACATTGGGAACACTTGGCTTCCAAAGCCCTGAAATATTTGGTG
ATGTTCCATACAATTTAAAACAAAGCTTAGTGTGTACTTTTGGGTGTGTA
GCATATTTTTGTCTAGAATTTCGAGTTCCATTTAAATCAGAAATTGAAAC
TAAAAAGTGTAATTTACCTAAAATCAATCTTTCATCAGAACTAGCTCGAT
CATTTATCACGGATTGCATTAAACTAGATCCCGATGAACGGATTGAATTT
GGTGACCTTCTTTCTCATGATTGGCTATATAACAAAGATAAGATTACTAG
CTATAATCCGATGGCAATTGCAAAATCTTTGTGGAATATTTTTAGTAATT
TGATTAAATCATAAATATTGTTTTTGATATCTAATAAATCAAATTATTT
back to top

protein sequence of SMED30008746-orf-1

>SMED30008746-orf-1 ID=SMED30008746-orf-1|Name=SMED30008746-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=188bp
FTMAFPIEKPIKTIIKNLIIIVYEMSEIGYYHRDIKPENIMVNKETLEVK
LIDLEDVLFDQYDIPICNSTLGTLGFQSPEIFGDVPYNLKQSLVCTFGCV
AYFCLEFRVPFKSEIETKKCNLPKINLSSELARSFITDCIKLDPDERIEF
GDLLSHDWLYNKDKITSYNPMAIAKSLWNIFSNLIKS*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
GO:0019012virion
GO:0030430host cell cytoplasm
Vocabulary: biological process
TermDefinition
GO:0043066negative regulation of apoptotic process
GO:0006468protein phosphorylation
GO:0016310phosphorylation
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000240body wall musculature
PLANA:0000429neoblast
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 5..159
e-value: 7.7E-6
score: -52.6
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 9..159
e-value: 3.4E-18
score: 66.0
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 1..159
score: 18.21
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 6..177
e-value: 1.8E-27
score: 98.0
NoneNo IPR availablePANTHERPTHR24347:SF412CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE Icoord: 8..166
NoneNo IPR availablePANTHERPTHR24347SERINE/THREONINE-PROTEIN KINASEcoord: 8..166
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 30..42
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 11..183