Guanylate cyclase

Overview


Name	Guanylate cyclase
Smed ID	SMED30008651
Length (bp)	3660

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Guanylate cyclase (SMED30008651) t-SNE clustered cells

Violin plots show distribution of expression levels for Guanylate cyclase (SMED30008651) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Guanylate cyclase (SMED30008651) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Guanylate cyclase (SMED30008651) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30008651

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
parapharyngeal region	SMED30008651	h1SMcG0001332	SmedASXL_017237	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
pharynx	SMED30008651	h1SMcG0001332	dd_Smed_v4_9453_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30008651	h1SMcG0001332	dd_Smed_v4_9453_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30008651	h1SMcG0001332	dd_Smed_v4_9453_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neuron	SMED30008651	h1SMcG0001332	dd_Smed_v4_9453_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30008651	h1SMcG0001332	dd_Smed_v4_9453_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30008651	h1SMcG0001332	dd_Smed_v4_9453_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30008651	h1SMcG0001332	dd_Smed_v4_9453_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30008651	h1SMcG0001332	dd_Smed_v6_9453_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
photoreceptor neuron	SMED30008651	h1SMcG0001332	SMED30008651	smed_20140614	PMID:22884275 Lapan et al., 2012
pharynx	SMED30008651	h1SMcG0001332	dd_Smed_v6_9453_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943])

HSP 1 Score: 619.772 bits (1597), Expect = 0.000e+0
Identity = 313/557 (56.19%), Postives = 397/557 (71.27%), Query Frame = 2

Query: 1850 DIDPMVAIRNGKHRGS-----ASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGC-HGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            D++P    R+ +  GS         +Y SL+T  G         QVF KTA +KGN+VA+K++N  ++ E T+++L ++K ++D+ N+H+ RF+G C +P +  ++ EYCP+GSL+D+LENE I LDWMFR SL  DIV+GM++LH+   C HG+LKSSNCVVD RFVLK+TD+GL   R++  E       H  Y K LWT+PE+LR  + P  G+  GDVYSF II QEI  R GVF V+  D   PKEI+E V   +  PFRPSL  +     +L  ++++ W EDP  RP F  I+ ++RK ++ + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP  NGR HA E+ARM L  L A+  F I HRP  QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S  T  VL+ F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  514 DVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQG-----HTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLD-LSPKEIIERVTRGEQPPFRPSL-ALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNR-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054

HSP 2 Score: 179.874 bits (455), Expect = 3.535e-45
Identity = 122/429 (28.44%), Postives = 208/429 (48.48%), Query Frame = 2

Query:  458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLK---NYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT-----GLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDG--SLCKKDGTSTGLIFGCTTAALFVIGV-IGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
            F+GP  + +   + R +   +   L++ G     F  KD  +Y   TR   ++  L +F+  L +   W  R    +  +   D+ +   F+  + +  R++   N   +  +     L      L+ +    RVI IC +    R +ML A+E  L   ++VF H+D+F      G  P P    +  D  + S R AF++  I+  K P N EY        L+ +A E++NF+     +N +  SF++ ++LY  A+ +  A   T+   + IT  MWNR+F G    +KID+ G+R +DFSL+D+DP++G F+ V  YNG+++    + G+ + W      PP D PKC FD     C +D  ST  +      +L ++G+ I  FF YR+++ + EL +  W + WE ++     +H +S  SR
Sbjct:  113 FLGPGCVYAAAPVGRFT-AHWRVPLLTAGAPALGFGVKD--EYALTTRAGPSYAKLGDFVAALHRRLGW-ERQALMLYAYRPGDEEHC--FFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLE--FLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNW--PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLAL-VGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSR 530

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR2 (natriuretic peptide receptor 2 [Source:HGNC Symbol;Acc:HGNC:7944])

HSP 1 Score: 606.675 bits (1563), Expect = 0.000e+0
Identity = 311/550 (56.55%), Postives = 391/550 (71.09%), Query Frame = 2

Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            H+G+ S         SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RFIG C++P +  +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++    HG LKSSNCVVDSRFVLK+TD+GL   R      S  EP  SH  Y K LWT+PE+L    LP  G  K DVYSF II QEI  R G F ++  D   PKEIV+ V++ +   FRPS+D     + +L+ ++++ W +DP  RPDF  IK  +R+ +K  E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HA EIARM L  L A+  F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S +T + L     F +  RG+VEMKGKGK  TYWL GE
Sbjct:  508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039

HSP 2 Score: 147.517 bits (371), Expect = 3.791e-35
Identity = 112/431 (25.99%), Postives = 194/431 (45.01%), Query Frame = 2

Query:  458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLKNYK-TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
             +GP  +    ++AR + + +   L++ G     F  K+   Y+ L R   +   L  F+  L   + W  R      + Y+D ++    ++++ + + E L+    +  ++  A       +    + +  R++ ICG  +    I+L A    L   ++VF ++D+F        T    RPW D ++ ++  +++R AF+++L++  + P N EY      N L   ARE +        +N +   FY+ I+LYA  LN+   +  T +   RI   M  R ++G    V +D   +R +DF L+ + D  SG+FQ    Y+G+ E      G+ I W   K  PP D P CAFD     C K   ST  I    T   F++  +  F  +R+L  + EL +M W I WE L      ++ +   SR
Sbjct:   96 LLGPGCVYPAASVARFA-SHWRLPLLTAGAVASGFSAKND-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSR 514

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2F (guanylate cyclase 2F, retinal [Source:HGNC Symbol;Acc:HGNC:4691])

HSP 1 Score: 436.802 bits (1122), Expect = 2.588e-133
Identity = 238/520 (45.77%), Postives = 340/520 (65.38%), Query Frame = 2

Query: 1985 ALFKGNIVALKKINTGR--KFETTKEMLLDI-KKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSF-QTFIMSERGEVEMKGKGKQLTYWLHGENDFIVD-PVP 3529
            A+++G+ V LKK + G     ++ K    D+ + +KDL +++I   +G   +     +V E+C +GSLED+L N+ + LDWMF+ SL+ D+++GM YLH     HG LKS NCVVD RFVLK+TD+G N + E+ + +  E       +++LWT+PE+LR      +G+  GDVYSFAII QE++ R   F + +  ++   EI+  +K  K  P    +   +    + ++++KQ W E    RP F  I N  +  +KGK++ NI+D++L  +EQY++NLE L+ +RT+E   EK++ E LL  MLP SVA  L K  +V  E ++ VT+YFSDIVGFT++SA S P++V++LLN LYT FD+II + DVYKVETIGDAYMV SGLP  NG  HA EIA M L  LS++  F + H P   + +RIG+HSGPV AGVVG  MPRYCLFGDTVNT+SRMES GLP +IH+S ST+ +L++  + + +  RG  E+KGKG + T+WL G+  F+   PVP
Sbjct:  564 AIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSM----EELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQ---EIINRLK--KPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKT-NIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVP 1073

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2D (guanylate cyclase 2D, retinal [Source:HGNC Symbol;Acc:HGNC:4689])

HSP 1 Score: 427.943 bits (1099), Expect = 5.474e-130
Identity = 236/531 (44.44%), Postives = 331/531 (62.34%), Query Frame = 2

Query: 1985 ALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVE-----PLHQY-----LVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSE-RGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKI 3544
             +++G+ V LKK    +             K+++L ++++  ++G+ +      P   +     +V E+C +GSL+DLL   +I LDWMF+ SL+ D+++G+ YLH     HG LKS NC+VD RFVLK+TD G   L E QK    E P  E     LWT+PE+LR   L   GT+ GDV+S AII QE++ R   +A+       P+E+V+ V+S    P    L  +D    + I ++KQ W E P  RP      +  + I+KG+++ NI+D++L  +EQY++NLE L+ +RT+E   EK++ + LL  MLP SVA  L     V  E +EQVT+YFSDIVGFT++SA S P++V++LLN LYT FD+II + DVYKVETIGDAYMV SGLP  NG+ HA EIA M L  LSA+  F + H P   + +RIG+HSGP  AGVVG  MPRYCLFGDTVNT+SRMES GLP +IH++ ST+ +L++  +    E RG  E+KGKG + T+WL G   F   P+P+   +
Sbjct:  553 GVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLP-EPPRAE---DQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLELT---PEEVVQRVRSPP--PLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKT-NIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGF-NKPIPKPPDL 1072

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2C (guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:4688])

HSP 1 Score: 414.461 bits (1064), Expect = 2.525e-125
Identity = 233/532 (43.80%), Postives = 329/532 (61.84%), Query Frame = 2

Query: 2048 TKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQIN------LDWMFRLSLIQDIVRGMIYLHSNYG-CHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSL--DEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKI-----DKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQT-FIMSERGEVEMKGKGKQLTYWLHGEND----FIVDPVPESAKIIQCE*KMIIIKIVQ 3586
            T++  +++ K+  ++  ++ +F G        + V EYC +GSL ++L N+ I+      +DW F++S++ DI +GM YLHS+    HG LKS+NCVVDSR V+K+TDFG N +   +K+              LWT+PE LR   +    + KGDVYS+ IIAQEII R+  F   +C  ++ K I     S+   PFRP L  +  +    ++  ++K  W+EDP  RPDF  I+ ++ KI     D+  ES   +D L+ R++ Y+ NLE LV +RTQ Y  E+ RA+ L + +LP+ V   L +   V  E YE+VTIYFSDIVGFT++   STPM+V+++LN +Y +FD I+++ DVYKVETIGDAYMV SGLP  NG  HA +IA+M L+ LS +  F + H P   + +RIGVHSGP  AGVVG KMPRYCLFGDTVNT+SRMES GLPL+IH+S ST+ +LK  +  F+   RGE  +KG+G + TYWL G  D        P  E+ + +Q E   +I   +Q
Sbjct:  526 TEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKD--------------LWTAPEHLRQANI----SQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEK-IFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNES--YMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQ 1035

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BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 603.594 bits (1555), Expect = 0.000e+0
Identity = 302/547 (55.21%), Postives = 391/547 (71.48%), Query Frame = 2

Query: 1916 MSLVTISGVQLENI--QNTQVFIKTALFKGNIVALKKINTGRK----FETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVK---SSKHVPFRPSLDEI------DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
            +S  + SG  +E I   NTQ++ KTA+FKG +VA+KK+N   K     + ++  L+++KK+KDL +DHI RF G C++  H  +V EYCPKGSLED+LENE+I LD + + SL+ D+V+G+ +LH S    HG LKSSNCVVDSRFVLK+TDFGL+ L  +++ N  E   H YYKKMLWT+PE+LR    P +GT KGD+YSFAII  E+++R+GVFA++N D   P EIV+ V+   S    P RP + E       D  +  L+ ++   W EDP+ RP+   ++ ++R +++  E+ N++DNLL RMEQYANNLEGLV +RTQEYL EKK+ E+LL+ +LP ++A  LI  ++V AESY+ VTIYFSDIVGFTSLS+ STPMQV+ LLN LY  FD +++NF VYKVETIGDAYMVVSGLP     +HA +IA+M L  L  +  FVI HRP+ QL+LRIG+HSG V AGVVG KMPRYCLFGDTVNTSSRMESNGLPLKIH+S  T ++L     F +  RG VEMKGKG Q TYWL G  D
Sbjct:  721 VSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLS-PNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRD-DHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1265

HSP 2 Score: 159.844 bits (403), Expect = 3.323e-39
Identity = 149/524 (28.44%), Postives = 241/524 (45.99%), Query Frame = 2

Query:  272 KKLGPITDLALARIEKLKKKGELQGFAN--------YSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIG------VFYIDDK-------------------SYSDYF--YSAKE-MMERLKNYKTE--------GYKADASSLKE-IREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLS-EFVFIHIDLFTGLNP-RPWF-DQKSSDEVNESVRNAFRSMLIVKLPLNS--EYWNSSIGNDLRKIAREKYNFSY---PKEELNYVTTSFYESIMLYALALNDLYAKNDTLD-----RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKR 1669
            +K  P+ D+A+  + K KK     G+ N        Y   L     +TV     +++ +    LD    A +G      L T+ +++    N  +  L  +G       K +Y  LTR+ G++  L + M +L+ ++        N        +F+  DK                   S   YF  Y+ K    E+ K +K E         +  D    +E  ++ L+ +S  S VII+C +    R IMLAA ++ +  S E+VFI+ID+ TG +  +PW     +++E NE  + A+R++  + L  +   EY N  +   +++ A +KYN++       E+N   ++FY++++LYA+ALN+       LD      IT+ MW RTF G    V ID  G+R SD+SL DLDP    F +V +Y+G++     +    + W   K  PP D P C +D S C        L+ G     L ++G+    F +RR K + EL AM+W I WE LD  E +
Sbjct:   62 QKAMPVIDIAVQEVIKAKKLPP--GWINLTYWDSRLYEDILLAERHATVG----VIQAYCEHRLD----AILGFADNYGLATVTKVTAG-LNGGIPILTTSGMPSLLNSKKEYPFLTRMQGSYRLLADSMYQLIAYHDEDSVSKSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSSHCYFSLYAIKRYFTEKSKTFKREWALNTPQFPFDEDLVIERETFKQWLREISLQSNVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFEL--RVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSG--LDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGYDKSKCPGYPLHVYLLMGSFLLILVLVGLF--IFFWRRYKLEQELAAMSWKIRWEELDGEESQ 564

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BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 602.823 bits (1553), Expect = 0.000e+0
Identity = 302/547 (55.21%), Postives = 391/547 (71.48%), Query Frame = 2

Query: 1916 MSLVTISGVQLENI--QNTQVFIKTALFKGNIVALKKINTGRK----FETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVK---SSKHVPFRPSLDEI------DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
            +S  + SG  +E I   NTQ++ KTA+FKG +VA+KK+N   K     + ++  L+++KK+KDL +DHI RF G C++  H  +V EYCPKGSLED+LENE+I LD + + SL+ D+V+G+ +LH S    HG LKSSNCVVDSRFVLK+TDFGL+ L  +++ N  E   H YYKKMLWT+PE+LR    P +GT KGD+YSFAII  E+++R+GVFA++N D   P EIV+ V+   S    P RP + E       D  +  L+ ++   W EDP+ RP+   ++ ++R +++  E+ N++DNLL RMEQYANNLEGLV +RTQEYL EKK+ E+LL+ +LP ++A  LI  ++V AESY+ VTIYFSDIVGFTSLS+ STPMQV+ LLN LY  FD +++NF VYKVETIGDAYMVVSGLP     +HA +IA+M L  L  +  FVI HRP+ QL+LRIG+HSG V AGVVG KMPRYCLFGDTVNTSSRMESNGLPLKIH+S  T ++L     F +  RG VEMKGKG Q TYWL G  D
Sbjct:  662 VSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLS-PNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRD-DHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1206

HSP 2 Score: 174.866 bits (442), Expect = 6.956e-44
Identity = 147/509 (28.88%), Postives = 248/509 (48.72%), Query Frame = 2

Query:  233 EKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKW----------LPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKA------DASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLS-EFVFIHIDLFTGLNP-RPWF-DQKSSDEVNESVRNAFRSMLIVKLPLNS--EYWNSSIGNDLRKIAREKYNFSY---PKEELNYVTTSFYESIMLYALALNDLYAKNDTLD-----RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKD-GTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKR 1669
            E + G N  +    K  P+ D+AL  +  L+           SLK+ F E+S +S+     K   ++  ++ V A +G   + +L  +AR+S   + + +          E  D+ ++  LTR+ G+++SL   + ++ + ++W          + R  +N        K  S+ ++S   +   + N KT  +        +A  L + R  L   S MS +II+C +    R IMLAA ++ +  S E+VFI+ID+ TG +  +PW     +++E NE  + A+R++  + L  +   EY N  +   +++ A +KYN++       E+N   ++FY++++LYA+ALN+       LD      IT+ MW RTF G    V ID  G+R SD+SL DLDP    F +V +Y+G++     +    + W   K  PP D P C +D S C +       L+ G     L ++G+    F +RR K + EL AM+W I WE LD  E +
Sbjct:   38 EGDRGKNPFLLTLAKSKPVFDVALQDVYHLRI------LPYGSLKVTF-ENSALSDAVGPQKMIEHYC-NKTVDAIMGLPYVYALAPVARISKF-WGQGVPVFTTTALVDELGDRNEFPLLTRMMGSYKSLGKLVTRIAERFEWQHYFFMFNDEVARGPRN--------KGRSECYFSLSAIKNLIMNNKTSTWNVKMFSEFEADRL-QYRALLSEASVMSNLIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFEL--RVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSG--LDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGYDKSKCPQGYPLHVYLLMGSFLLILVLVGLF--IFFWRRYKLEQELAAMSWKIRWEELDGEESQ 518

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BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 602.053 bits (1551), Expect = 0.000e+0
Identity = 302/547 (55.21%), Postives = 391/547 (71.48%), Query Frame = 2

Query: 1916 MSLVTISGVQLENI--QNTQVFIKTALFKGNIVALKKINTGRK----FETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVK---SSKHVPFRPSLDEI------DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
            +S  + SG  +E I   NTQ++ KTA+FKG +VA+KK+N   K     + ++  L+++KK+KDL +DHI RF G C++  H  +V EYCPKGSLED+LENE+I LD + + SL+ D+V+G+ +LH S    HG LKSSNCVVDSRFVLK+TDFGL+ L  +++ N  E   H YYKKMLWT+PE+LR    P +GT KGD+YSFAII  E+++R+GVFA++N D   P EIV+ V+   S    P RP + E       D  +  L+ ++   W EDP+ RP+   ++ ++R +++  E+ N++DNLL RMEQYANNLEGLV +RTQEYL EKK+ E+LL+ +LP ++A  LI  ++V AESY+ VTIYFSDIVGFTSLS+ STPMQV+ LLN LY  FD +++NF VYKVETIGDAYMVVSGLP     +HA +IA+M L  L  +  FVI HRP+ QL+LRIG+HSG V AGVVG KMPRYCLFGDTVNTSSRMESNGLPLKIH+S  T ++L     F +  RG VEMKGKG Q TYWL G  D
Sbjct:  683 VSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLS-PNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRD-DHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1227

HSP 2 Score: 183.726 bits (465), Expect = 1.098e-46
Identity = 150/508 (29.53%), Postives = 253/508 (49.80%), Query Frame = 2

Query:  239 NNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES---STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKW---------LPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKT--EGYKADASSLK---EIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLS-EFVFIHIDLFTGLNP-RPWF-DQKSSDEVNESVRNAFRSMLIVKLPLNS--EYWNSSIGNDLRKIAREKYNFSY---PKEELNYVTTSFYESIMLYALALNDLYAKNDTLD-----RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKD-GTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKR 1669
            ++G N  + +S K+ P+ DLAL   E++ ++G L    N S+ L + +S     +  +  + +     +L + +   IG     +L  +ARMS   +   +  +   G      DK +YQ +TRI   ++ +++ +  L   YKW            P   +G  ++   S     +  +++ME   N+ T  E + A+ S  +   + R  L+  S+M+ VII+C +    R IMLAA ++ +  S E+VFI+ID+ TG +  +PW     +++E NE  + A+R++  + L  +   EY N  +   +++ A +KYN++       E+N   ++FY++++LYA+ALN+       LD      IT+ MW RTF G    V ID  G+R SD+SL DLDP    F +V +Y+G++     +    + W   K  PP D P C +D S C +       L+ G     L ++G+    F +RR K + EL AM+W I WE LD  E +
Sbjct:   57 SDGKNPFLFSSHKVKPLADLAL---ERVYREGIL---PNNSVNLIYRDSKLSDAIGPNVAVEQ-----LLRKQIDCIIGYAYGYALAPVARMS-PYWKNGIPIITPIGLTMSLDDKREYQLMTRINSPYKVVSSAVSTLFNTYKWKRHIFMFHHAKAPSVAVGECFLLMASLQ---HPLRKVMEMQHNFFTFNEDHGANISKAERHNQFRNYLRASSNMANVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFEL--RVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSG--LDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGYDKSKCPQGYPLHVYLLMGSFLLILVLVGLF--IFFWRRYKLEQELAAMSWKIRWEELDGEESQ 539

[Close]

BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 556.984 bits (1434), Expect = 0.000e+0
Identity = 285/539 (52.88%), Postives = 379/539 (70.32%), Query Frame = 2

Query: 1916 MSLVTISGVQLENI--QNTQVFIKTALFKGNIVALKKINTGRK----FETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVK---SSKHVPFRPSLDEI------DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQT-----FIMSERGEVEMKGK 3469
            +S  + SG  +E I   NTQ++ KTA+FKG +VA+KK+N   K     + ++  L+++KK+KDL +DHI RF G C++  H  +V EYCPKGSLED+LENE+I LD + + SL+ D+V+G+ +LH S    HG LKSSNCVVDSRFVLK+TDFGL+ L  +++ N  E   H YYKKMLWT+PE+LR    P +GT KGD+YSFAII  E+++R+GVFA++N D   P EIV+ V+   S    P RP + E       D  +  L+ ++   W EDP+ RP+   ++ ++R +++  E+ N++DNLL RMEQYANNLEGLV +RTQEYL EKK+ E+LL+ +LP ++A  LI  ++V AESY+ VTIYFSDIVGFTSLS+ STPMQV+ LLN LY  FD +++NF VYKVETIGDAYMVVSGLP     +HA +IA+M L  L  +  FVI HRP+ QL+LRIG+HSG V AGVVG KMPRYCLFGDTVNTSSRMESNGL +  + S   +   K F+      F+ +E+  +E +GK
Sbjct:   94 VSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDL-SPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRD-DHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLRMFWNFSLYKIYKFKVFKNKIELDFLKNEKESIEFEGK 630

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BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-21 (Receptor-type guanylate cyclase gcy-21 [Source:UniProtKB/Swiss-Prot;Acc:O16715])

HSP 1 Score: 450.284 bits (1157), Expect = 1.382e-138
Identity = 267/706 (37.82%), Postives = 401/706 (56.80%), Query Frame = 2

Query: 1415 EGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQIS-RKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSN-YGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQT-LPFIGTV---KGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV---PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            EG SI++ N+    P DTP C F G  C     +T +I      A+ +   I   F Y+R +++  L ++ ++I    +  ++K  +  SQ S R  ++++ +++                     +  +   ++   +   N+ S I+       G    +           ++G   +   +        L++G  VALK+I      E T+ + L+I K+++  N ++  F+GM V+    ++VYE   +GSL+D+L+N+ + LD +FR  + +DI+ G+ YLHS+  GCHG LKS+NC++D+R++++L+ FGL  LR   +E   +E   +  K  LWTSPE+LR  T L   G +   K DVYS AI+  E+  R G +     +  +P+EIV  VK        PFRP +  +      + + +  AW EDP NRP    IK  ++ +  G +   I+DN++S +E+Y + LE  +A+R +E   EK ++E LL  MLP+ VA  L    +VSAES+E  T++FSD  GF  +SA S P+ +++ LN LYT FD II+ FDVYKVETI DAYMV SGLP  NG +HA EIA + L  L A+  F I H PN ++ LRIG++SGP  AGVVG KMPRYCLFGDTVNT+SRMESNG+PL+I+ S +  E+L     + + ERG VEMKGKGKQ+TY++ GEN
Sbjct:  345 EGLSIDFVNKS--APKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLAIAAAFLYKRYRYERRLHSLFFMIDRNQI-ILKKHTNLMSQQSLRSMASIHGSVV---------------------AASQTLRDSHFFIEDYNNASSINASSIFNTGSTARAGPFGPIPGFGGVTGASEDEKWHQIPDFGVGLYEGRTVALKRIYRS-DVEFTRSIRLEIAKLQESVNSNVIEFVGMVVQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHSSPIGCHGRLKSTNCLIDARWMVRLSSFGLRELR--GEETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLLVQKSDVYSLAIVLYELFGRLGPWG---DEPMEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQETVVAAWTEDPLNRPSLHQIKRKLKPLTIGLKR-TIMDNMVSMIEKYTDKLEKDIAERNEELEGEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFLNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGGYEIEERGIVEMKGKGKQMTYFVRGEN 1019

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG3216 (gene:FBgn0034568 transcript:FBtr0273396)

HSP 1 Score: 620.157 bits (1598), Expect = 0.000e+0
Identity = 409/1129 (36.23%), Postives = 590/1129 (52.26%), Query Frame = 2

Query:  272 KKLGPITDLALARIEK----------LKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFE-----------------------FKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSL----KEIREK-LKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQ--KSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPK-EELNYVTTSFYESIMLYALALND-LYAKNDTLD--RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGF-FAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVE-PLHQYLVY-EYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFI--GTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
            ++ GP  DLAL  I K          LKKKG              S  S        +    YF  D  V AFIGP    +L  +AR++       +  +G+     E                       FKDK +Y  LTR++     L      +++ + W      N     +D      + ++  + +E     + EG  +    L    +E+ E  LK  S  +RV+I+       R  MLAA  + +   E+VF+ +++F       W D+  +  DE +   R A+ ++L V L   +        +++R+ A   YN+++ + EE+N+   +FY+ + L  +ALN+ L    D  D   IT  MWNRTF G    V+ID  G+R +D+S+ DLDP +G F  V  Y+G  + YS + GK I W   + EPP D P C F G+     G  + +++      LF+  V        +++K   EL  M+W +                   R D  + E                   G   GSK  ++              D++ +   + G H G AS  S+ SL              QV+     FKG  VA+KK+N  +K + T ++L +IK+ +D+++++  RF+G C++ P    L+  EYC +GSL+D+LENE I LDW FR+SLI DIV+GM YLH S+   HG L+S NC++D RFVLK++DFGL  L       S+      YY K+LW +PE+L   T+P     T +GDVYSF II +EI+ R G +  +     D   I+  V+      FRP + E + C  DL++++++ W ++   RP F  I++++R I KG    N++D+LL+RMEQYANNLE LV ++T++   EK+R E+LLY +LP+ VA QL+    V  E +  VTIYFSDIVGFT L A S+PM V+  LN LY+TFD II  +DVYKVETIGDAY+VVSGLP  NG  HAREIA M L  L A+  F + H+P  ++++RIG+HSG VCAGVVG KMP YCLFGDTVNT+SRMES G P KIH+S +T  +L  F TF M +RG+VE+KGKG   TYWL+  ++
Sbjct:  106 ERCGPAVDLALDEINKVFLKPHNITLLKKKG--------------SYPSCSGARAPGLAADMYFQDD--VIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNW------NHVALLVDRSEL--FSWTVGKNLEY--GLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQS---EYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRV-------------------RPDDVLIEM------------------GGMFGSKGGLQR------------LDVENISLQQFGIHSGRASIASFTSL------------PPQVYTTIGQFKGERVAIKKVNV-KKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTL----TTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQ-EARQQMDVHTILHKVRQCNG--FRPLIRERE-CPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGF-CENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSE 1134

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BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0346151)

HSP 1 Score: 594.349 bits (1531), Expect = 0.000e+0
Identity = 305/539 (56.59%), Postives = 389/539 (72.17%), Query Frame = 2

Query: 1922 LVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGR-KFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHS-NYGCHGHLKSSNCVVDSRFVLKLTDFGLNILR----EIQKENSNEEPSHEYYKKMLWTSPEILRTQ-TLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCD-SKDPKEIVESVKS----SKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            +V+I+G       + Q+FI   +F+ + VA+K +     +   T+ ++L++K++KDL +DH+ +F G C++    +L+ EYCPKGSL+D+LENEQ  LDWMFRLSL+ DIVRGM +LHS +   HG+LKSSNCVVDSRFVLK+TDFGL+ LR    +++ +  N   SH Y+ K+LWT+PE+LR +   P  GT KGDVY+F II  EI  R+G F +  C   K P+EI+E VK         PFRP L+      +D+  II++ W EDP  RPDF  +K+ +R+ +K  E+GNI+DNLL RME YANNLE LV +RTQ+Y EEKK+ E LLY +LP+SVA QLI  Q V AE+++QVTIYFSDIVGFT++SA+STPMQV++ LN LYT FDSI+ENFDVYKVETIGDAYMVVSGLP  NG  HAREIAR+ L  L A+  F I HRP  +L+LRIG+H+G   AGVVG KMPRYCLFGDTVNT+SRMESNG  LKIHIS +T E L  F TF+ + RG V MKGKG+ LTYWL GE
Sbjct:  601 MVSING-------DRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCN-SHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131

HSP 2 Score: 189.504 bits (480), Expect = 2.931e-48
Identity = 145/515 (28.16%), Postives = 254/515 (49.32%), Query Frame = 2

Query:  176 KKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEP-VHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQ-YQGLTRIAGNH-ESLTNFMGKLLKFYKWLPRPHKNIGVFYIDD----KSYSDYFYSAKEMMERLKNYKTE--GYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKL-DLSEFVFIHIDLFTG---LNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYP-KEELNYVTTSFYESIMLYALALNDLYAKNDT-LDRITN------YMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
            ++L  R   + V +  S +E +N N+ I+    K+ P+ +LA+  ++++       G +++ ++L   ++   S++  I   FF      P V+A  G      L  I+R +       L + G A    EF  K + Y  LTR+ G    +L N +  +L  + W         + Y ++    K  S  F     + + ++ +     G+     +  +I   LK ++  SR++I+C   +  R IML A E+ + D  E+VFI+I+LF+    L  +PW+D+  +D  NE  + A+ +ML V  K P ++EY  + + N+++ IA EKYN+++   E ++   TSF++ ++LYA ALN+   ++ T L R  N       MWNR+F G    V IDA G+R+S +SL D++P +G F+ V  +  +   +     K I W  ++ E P D P C +DG+LC  +      I       + V+  +  FF YR    +AE+ +M+W +  E +
Sbjct:   78 RRLGARRQLVFVALLPS-VESDNKNDCIM---PKVLPVLELAIRHVQRMG----FVGGSHFDIQLISRDTFCSSKYGPI--GFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAK---EFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNW-----TRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEY--TRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFE--ANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDV 570

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BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0083187)

HSP 1 Score: 594.349 bits (1531), Expect = 0.000e+0
Identity = 305/539 (56.59%), Postives = 389/539 (72.17%), Query Frame = 2

Query: 1922 LVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGR-KFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHS-NYGCHGHLKSSNCVVDSRFVLKLTDFGLNILR----EIQKENSNEEPSHEYYKKMLWTSPEILRTQ-TLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCD-SKDPKEIVESVKS----SKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            +V+I+G       + Q+FI   +F+ + VA+K +     +   T+ ++L++K++KDL +DH+ +F G C++    +L+ EYCPKGSL+D+LENEQ  LDWMFRLSL+ DIVRGM +LHS +   HG+LKSSNCVVDSRFVLK+TDFGL+ LR    +++ +  N   SH Y+ K+LWT+PE+LR +   P  GT KGDVY+F II  EI  R+G F +  C   K P+EI+E VK         PFRP L+      +D+  II++ W EDP  RPDF  +K+ +R+ +K  E+GNI+DNLL RME YANNLE LV +RTQ+Y EEKK+ E LLY +LP+SVA QLI  Q V AE+++QVTIYFSDIVGFT++SA+STPMQV++ LN LYT FDSI+ENFDVYKVETIGDAYMVVSGLP  NG  HAREIAR+ L  L A+  F I HRP  +L+LRIG+H+G   AGVVG KMPRYCLFGDTVNT+SRMESNG  LKIHIS +T E L  F TF+ + RG V MKGKG+ LTYWL GE
Sbjct:  601 MVSING-------DRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCN-SHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131

HSP 2 Score: 189.504 bits (480), Expect = 2.931e-48
Identity = 145/515 (28.16%), Postives = 254/515 (49.32%), Query Frame = 2

Query:  176 KKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEP-VHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQ-YQGLTRIAGNH-ESLTNFMGKLLKFYKWLPRPHKNIGVFYIDD----KSYSDYFYSAKEMMERLKNYKTE--GYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKL-DLSEFVFIHIDLFTG---LNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYP-KEELNYVTTSFYESIMLYALALNDLYAKNDT-LDRITN------YMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
            ++L  R   + V +  S +E +N N+ I+    K+ P+ +LA+  ++++       G +++ ++L   ++   S++  I   FF      P V+A  G      L  I+R +       L + G A    EF  K + Y  LTR+ G    +L N +  +L  + W         + Y ++    K  S  F     + + ++ +     G+     +  +I   LK ++  SR++I+C   +  R IML A E+ + D  E+VFI+I+LF+    L  +PW+D+  +D  NE  + A+ +ML V  K P ++EY  + + N+++ IA EKYN+++   E ++   TSF++ ++LYA ALN+   ++ T L R  N       MWNR+F G    V IDA G+R+S +SL D++P +G F+ V  +  +   +     K I W  ++ E P D P C +DG+LC  +      I       + V+  +  FF YR    +AE+ +M+W +  E +
Sbjct:   78 RRLGARRQLVFVALLPS-VESDNKNDCIM---PKVLPVLELAIRHVQRMG----FVGGSHFDIQLISRDTFCSSKYGPI--GFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAK---EFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNW-----TRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEY--TRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFE--ANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDV 570

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304791)

HSP 1 Score: 508.834 bits (1309), Expect = 4.212e-159
Identity = 264/536 (49.25%), Postives = 358/536 (66.79%), Query Frame = 2

Query: 1919 SLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYK--KMLWTSPEILRTQTLPFI-GTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV--PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
            S V++S     + + T +F    L+KG + A+KK+   +  + T+EM  ++K ++D  +D+IC FIG C +P +  ++ EYC +GSL+D+LENE + LD MF  S++ DI+RG+IYLH S    HG L +SNC+VDSR+V+KLTDFGL   ++   E+S+ +  H   K  K+L+ +PE+LR      + GT +GD YSF I+  E+  RRG F         P + ++ V   +    P+RPSL  ++     + + +++ W E P +RPDF  I+  +R + KG    NI DN+++ ME+YANNLE LV  RT +  EEKK+ + LL+ MLP+ VA QL K   V  E YEQV+IYFSDIVGFT++SA+ TP+QV++ LN LYT FDSII ++DVYKVETIGDAYMVVSGLP  NG  HA EIA M L  LSA+  F I HRP  +L LRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMES+G+PLKIH S    ++L     +  +ERG + MKGKG Q TYWL GE++
Sbjct:  560 SQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRK-KSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQ-GIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLT---PMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRP-NIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1089

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304792)

HSP 1 Score: 508.449 bits (1308), Expect = 4.243e-159
Identity = 264/536 (49.25%), Postives = 358/536 (66.79%), Query Frame = 2

Query: 1919 SLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYK--KMLWTSPEILRTQTLPFI-GTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV--PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
            S V++S     + + T +F    L+KG + A+KK+   +  + T+EM  ++K ++D  +D+IC FIG C +P +  ++ EYC +GSL+D+LENE + LD MF  S++ DI+RG+IYLH S    HG L +SNC+VDSR+V+KLTDFGL   ++   E+S+ +  H   K  K+L+ +PE+LR      + GT +GD YSF I+  E+  RRG F         P + ++ V   +    P+RPSL  ++     + + +++ W E P +RPDF  I+  +R + KG    NI DN+++ ME+YANNLE LV  RT +  EEKK+ + LL+ MLP+ VA QL K   V  E YEQV+IYFSDIVGFT++SA+ TP+QV++ LN LYT FDSII ++DVYKVETIGDAYMVVSGLP  NG  HA EIA M L  LSA+  F I HRP  +L LRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMES+G+PLKIH S    ++L     +  +ERG + MKGKG Q TYWL GE++
Sbjct:  558 SQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRK-KSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQ-GIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLT---PMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRP-NIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1087

[Close]

BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4])

HSP 1 Score: 713.761 bits (1841), Expect = 0.000e+0
Identity = 404/895 (45.14%), Postives = 549/895 (61.34%), Query Frame = 2

Query:  854 IIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT-GLNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR-----ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            + +C +    R +++   +  L   E+VF +ID+F      RP       D  +   + AF+S+ I+    P N EY       DL+  A+  +NF+     +N ++  FY+ +MLY  ALN+  + +D+ +R     ++  MWNRT+ G    V+ID  G+R +DF+L+D+ D  +G+FQ V  YNG+ +  +++ G +I+W   K   P+D P C F  +   C+    +   +       + +I      F YR+LK + EL A  W I W+ +           Q+S  +  +  T                      GSK  + +                          RGS    +Y SL+T  G       N QVF KT  FKGNIVA+K IN  R+ E T+++L ++K ++D+ N+H+ RFIG C++P +  +V EYCP+GSL+++LEN+ I LDWMF+ SLI DIV+GM +LH S    HG+LKSSNCVVD+RFVLK+TD+GL+ +R      S+ E +H YY + LW +PE+ R +  P  GT KGDVYSF II QE+  RRGVF ++  D   PKEIV+ V   +    RPSL+     S +L +++++ W E+P++RP+F  I   +RK ++   S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H REIARM L  L A+  F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S +T  VL+ F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:    2 VFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAKEAFQSVKILTYLEPQNQEY--KDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNE--SLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPGGK--VPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDI-----------QMSHLEKALRST----------------------GSKLTLSL--------------------------RGS----NYGSLLTTDG-------NFQVFAKTGYFKGNIVAIKYINR-RRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRT----ESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEG-DLLSPKEIVDRVALGEWPYLRPSLNP-QAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNREHRS-NILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 812

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BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4])

HSP 1 Score: 697.582 bits (1799), Expect = 0.000e+0
Identity = 418/1043 (40.08%), Postives = 594/1043 (56.95%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMER-----LKNYKTEGYKADASSLKEIREK----------LKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT-GLNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR-----ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            AFIGP    +   +   +   +   +++ G     F  + ++ Y  +T     H+ L  +   L + + W                 +S   +S  +M ER     L+   TE ++ + +++  + E+          L  +    RV+ +C +    R +++   +  L   E+VF +ID+F      RP       D  +   + AF+S+ I+    P N EY       DL+  A+  +NF+     +N ++  FY+ +MLY  ALN+  + +D+ +R     ++  MWNRT+ G    V+ID  G+R +DF+L+D+ D  +G+FQ V  YNG+ +  +++ G +I+W   K   P+D P C F  +   C+    +   +       + +I      F YR+LK + EL A  W I W+ +           Q+S  +  +  T                      GSK  + +                          RGS    +Y SL+T  G       N QVF KT  FKGNIVA+K IN  R+ E T+++L ++K ++D+ N+H+ RFIG C++P +  +V EYCP+GSL+++LEN+ I LDWMF+ SLI DIV+GM +LH S    HG+LKSSNCVVD+RFVLK+TD+GL+ +R      S+ E +H YY + LW +PE+ R +  P  GT KGDVYSF II QE+  RRGVF ++  D   PKEIV+ V   +    RPSL+     S +L +++++ W E+P++RP+F  I   +RK ++     +I+      + QYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H REIARM L  L A+  F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S +T  VL+ F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  125 AFIGPGCDYTSSPVGLFTA-HWGLPMITAGAPAVAF-LQMEI-YTSITNTGPTHKKLGEYALHLYRHFGW---------------NQHSLLMFSDTKMGERACYFALEGLYTEMHEENITTMDLVFEENKGPVNYSELLHKIQGDGRVVFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAKEAFQSVKILTYLEPQNQEY--KDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNE--SLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPGGK--VPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDI-----------QMSHLEKALRST----------------------GSKLTLSL--------------------------RGS----NYGSLLTTDG-------NFQVFAKTGYFKGNIVAIKYINR-RRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRT----ESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEG-DLLSPKEIVDRVALGEWPYLRPSLNP-QAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNRSVPHYSIV------LSQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1060

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BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:dkey-37g12.1 (si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-145])

HSP 1 Score: 643.269 bits (1658), Expect = 0.000e+0
Identity = 402/1034 (38.88%), Postives = 561/1034 (54.26%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKE-----IREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYP---KEELNYVTTSFYESIMLYALALNDLYAKN----DTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLC----KKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYL-HSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            AFIGP+        A+++   +N +++S   A  QF   DK  Y  LTR+ G    L  F  ++ K + W     ++IG+ Y    +++      K   E   N     Y+   SSL +         L  ++ ++R+I+I    K  R +++ A +  L   +FVF   + +        FD +  D  +   + A++++  + L   S+    +   ++  I+R K +F Y     E+++ +    ++++ LYA ALN+  A+N    D L  +T  MWNRT  G    V IDA G+R  ++ +  +   +   Q V  Y G   TY  ++G  I W      PP D+P C F G LC    +K   + G+I G   A    I V+     YR+ K   E   M W I   + + V   +H  S +  K                       +S   Q S E I                 D   A R   ++G           TI  V   N+++T +                           E+L ++K+ +DL + ++C+FIG  +E    +++ EYCPKGSL+D+L+NE I LDW F+ SL+ DIV+GM YL HS    HGHL SS+CVVDSRFVLK+TDFGLN +R +  E S   P  + +  +LW +PE+LR Q++P  GT KGDVYSFAIIAQE++YRRG F + N     P+EIVE V++    P RP +D  + C  +L  ++   W E P  RPDF  I+ +++K      S NILD+LLSRMEQYA NLE +V++RT E  EEKKRAE LL  MLP+SVA QLI  ++V AE+Y+ VTIYFSDI GFT++SA  TPMQV+ +LN LYT FD+II+  +VYKVETIGDAYMVVSGLP  NG +HA+EIARM L  +  +  F  PH P  QL +RIGVHSGP  AGVVG KMPRYCLFGDTVNT+SRMES GLPLKIH+S ST  +L +F+ F    RG++ +KGKG   T+WL GE+
Sbjct:   92 AFIGPSCSNVCAVTAKLAAF-WNIAVISPVCADQQF--LDKKAYPTLTRVFGPFTKLGAFFVEICKQFGW-----QHIGIIYDGKPTWAIPVEGIKYQAEH-NNITVAKYQDIHSSLSQGSTSNWSRVLNEMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFEPYKQKVLFGSFDWEQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAFSENV--ISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYAHALNETLAENGNPYDGL-AVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANYFG---TYKAVKGVQILWPGGLTSPPKDSPDCGFRGELCINLERKFLIALGIIAGLMAAGTLAICVL-----YRKYKLPEEASKMLWTI---NANDVIMMEHHSSTVPEKSH---------------------RSKPLQASLESIICSMQ------------DKPSAHRTAVYKG-----------TICSVSFVNLRSTHL-------------------------NSELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVRRLDTEQS---PGSDPWTALLWRAPELLR-QSIPANGTQKGDVYSFAIIAQEVVYRRGPFYIPN-SHFSPREIVERVRAGGCSPSRPYIDRAE-CVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKGKGWVRTFWLLGED 1027

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BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:dkey-37g12.1 (si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-145])

HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0
Identity = 394/1020 (38.63%), Postives = 551/1020 (54.02%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKE-----IREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYP---KEELNYVTTSFYESIMLYALALNDLYAKN----DTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLC----KKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYL-HSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMK 3463
            AFIGP+        A+++   +N +++S   A  QF   DK  Y  LTR+ G    L  F  ++ K + W     ++IG+ Y    +++      K   E   N     Y+   SSL +         L  ++ ++R+I+I    K  R +++ A +  L   +FVF   + +        FD +  D  +   + A++++  + L   S+    +   ++  I+R K +F Y     E+++ +    ++++ LYA ALN+  A+N    D L  +T  MWNRT  G    V IDA G+R  ++ +  +   +   Q V  Y G   TY  ++G  I W      PP D+P C F G LC    +K   + G+I G   A    I V+     YR+ K   E   M W I   + + V   +H  S +  K                       +S   Q S E I                 D   A R   ++G           TI  V   N+++T +                           E+L ++K+ +DL + ++C+FIG  +E    +++ EYCPKGSL+D+L+NE I LDW F+ SL+ DIV+GM YL HS    HGHL SS+CVVDSRFVLK+TDFGLN +R +  E S   P  + +  +LW +PE+LR Q++P  GT KGDVYSFAIIAQE++YRRG F + N     P+EIVE V++    P RP +D  + C  +L  ++   W E P  RPDF  I+ +++K      S NILD+LLSRMEQYA NLE +V++RT E  EEKKRAE LL  MLP+SVA QLI  ++V AE+Y+ VTIYFSDI GFT++SA  TPMQV+ +LN LYT FD+II+  +VYKVETIGDAYMVVSGLP  NG +HA+EIARM L  +  +  F  PH P  QL +RIGVHSGP  AGVVG KMPRYCLFGDTVNT+SRMES GLPLKIH+S ST  +L +F+ F    RG++ +K
Sbjct:   92 AFIGPSCSNVCAVTAKLAAF-WNIAVISPVCADQQF--LDKKAYPTLTRVFGPFTKLGAFFVEICKQFGW-----QHIGIIYDGKPTWAIPVEGIKYQAEH-NNITVAKYQDIHSSLSQGSTSNWSRVLNEMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFEPYKQKVLFGSFDWEQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAFSENV--ISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYAHALNETLAENGNPYDGL-AVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANYFG---TYKAVKGVQILWPGGLTSPPKDSPDCGFRGELCINLERKFLIALGIIAGLMAAGTLAICVL-----YRKYKLPEEASKMLWTI---NANDVIMMEHHSSTVPEKSH---------------------RSKPLQASLESIICSMQ------------DKPSAHRTAVYKG-----------TICSVSFVNLRSTHL-------------------------NSELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVRRLDTEQS---PGSDPWTALLWRAPELLR-QSIPANGTQKGDVYSFAIIAQEVVYRRGPFYIPN-SHFSPREIVERVRAGGCSPSRPYIDRAE-CVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIK 1013

[Close]

BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr2 (natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZDB-GENE-141030-2])

HSP 1 Score: 601.668 bits (1550), Expect = 0.000e+0
Identity = 309/537 (57.54%), Postives = 383/537 (71.32%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            S    SY SL+T  G         Q+F KT  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RFIG C++P +  +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM YLH++Y G HG+LKSSNCVVDSRFVLK+TD+GL   R     +   E SH  Y K LWT+PE+L     P  GT KGDVYSF II QEI  R G F V+  D   PKEI++ V++ +   FRP+ D    C  +L  +++  W EDP  RPDF  IK  + K +K  +    L   LSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HAREIA M L  L  +  F I HRPN QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMES G  L+IH+S +T EVL  F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  525 SQRGSSYGSLITAHG-------KYQLFAKTGYFKGNLVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCENEDSHALYAKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVEGMD-LSPKEIIQKVRNGQKPYFRPTTDNSRHCE-ELTILMEGCWSEDPAERPDFSHIKVFIAKFNKQHQYSQYL---LSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFELQLRGDVEMKGKGKMRTYWLLGE 1044

HSP 2 Score: 140.198 bits (352), Expect = 4.708e-33
Identity = 126/475 (26.53%), Postives = 220/475 (46.32%), Query Frame = 2

Query:  314 EKLKKKGELQGFANYSLKLFFSESS-TVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYS-AKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGA-SKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYA----KNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
            EK++K G L+G     L     +SS + SE++  +      +  +P  AFIGP    S+ ++ R + + +   L++ G   Y F+  +  +++ + R     + L +F+  L   + W  R          DD+ +  YF S     + R +N     +  +       ++ +  +    R++ ICG    + +++ L   E+K    ++   ++D+F    +G  P PW  Q S  + N+ ++  F+S+ +V    P + EY  ++   +L K A + +N       ++++   F++  +LYA AL++  A    +ND ++ IT  M NR   G    V ID +  R +DFSL+ + + KSG +  VG YNG+++       + I+W   K  PPLD P C F  S CK+D      I    +    +I  I  F  YR+LK + EL  M W I WE L      K+ +   SR
Sbjct:   64 EKIQKSGLLRGHTINLLNFSTEDSSGSCSENEAQIIAVDTKLYHKP-DAFIGPGCTYSVASVGRFA-SHWKLPLITAGGPAYGFDKWE--EFKTIVRTGPTTKKLGDFVNYLHGQFNWSSRALMIFHDLKQDDRPH--YFLSEGIYTVLREENITVLAFPYEDEQTYNYKDMITFIKDNGRIVYICGPLPTFFQIMKLFEDEVK-SPEDYAIFYLDVFAESLSGDVPMPW--QGSDIQWNDPIK-LFQSVFVVTYQEPDSPEY--TAFRKELHKRAIQDFNVQLEPSMMDFIAGCFHDGFVLYAKALSEALADGVSQNDGIN-ITARMQNRRLWGVTGLVSIDQKNARFTDFSLWAMTNLKSGQYAIVGHYNGTSKEILWSPTEKIQW--PKGCPPLDYPPCGF--SPCKEDHLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWEELQFESPNKYHKRAGSR 521

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BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 593.578 bits (1529), Expect = 0.000e+0
Identity = 308/533 (57.79%), Postives = 387/533 (72.61%), Query Frame = 2

Query: 1874 RNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
            R  K RGS    SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RF+G C++P +  +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S  G HG+LKSSNCVVDSRFVLK+TD+GL   R     +   + ++  Y K LWT+PE+LR    P  GT KGDVYSF II QEI  R G F +   D   PKEIV+ V++ +   FRP++D I   S +L  ++ + W E+P +RPDF  IK  + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H REIARM L  L A+  F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  L+IHIS +T EVL  F  F +  RG++EMK K
Sbjct:   87 RYHKTRGS----SYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 600

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BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 593.193 bits (1528), Expect = 0.000e+0
Identity = 304/526 (57.79%), Postives = 383/526 (72.81%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
            S    SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RF+G C++P +  +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S  G HG+LKSSNCVVDSRFVLK+TD+GL   R     +   + ++  Y K LWT+PE+LR    P  GT KGDVYSF II QEI  R G F +   D   PKEIV+ V++ +   FRP++D I   S +L  ++ + W E+P +RPDF  IK  + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H REIARM L  L A+  F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  L+IHIS +T EVL  F  F +  RG++EMK K
Sbjct:  167 SLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 677

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Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
            S    SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RF+G C++P +  +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S  G HG+LKSSNCVVDSRFVLK+TD+GL   R     +   + ++  Y K LWT+PE+LR    P  GT KGDVYSF II QEI  R G F +   D   PKEIV+ V++ +   FRP++D I   S +L  ++ + W E+P +RPDF  IK  + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H REIARM L  L A+  F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  L+IHIS +T EVL  F  F +  RG++EMK K
Sbjct:   37 SLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 547

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BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 592.808 bits (1527), Expect = 0.000e+0
Identity = 304/526 (57.79%), Postives = 383/526 (72.81%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
            S    SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RF+G C++P +  +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S  G HG+LKSSNCVVDSRFVLK+TD+GL   R     +   + ++  Y K LWT+PE+LR    P  GT KGDVYSF II QEI  R G F +   D   PKEIV+ V++ +   FRP++D I   S +L  ++ + W E+P +RPDF  IK  + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H REIARM L  L A+  F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  L+IHIS +T EVL  F  F +  RG++EMK K
Sbjct:  122 SLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 632

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Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
            S    SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RF+G C++P +  +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S  G HG+LKSSNCVVDSRFVLK+TD+GL   R     +   + ++  Y K LWT+PE+LR    P  GT KGDVYSF II QEI  R G F +   D   PKEIV+ V++ +   FRP++D I   S +L  ++ + W E+P +RPDF  IK  + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H REIARM L  L A+  F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  L+IHIS +T EVL  F  F +  RG++EMK K
Sbjct:  195 SLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 705

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr1 (natriuretic peptide receptor 1 [Source:MGI Symbol;Acc:MGI:97371])

HSP 1 Score: 621.313 bits (1601), Expect = 0.000e+0
Identity = 308/537 (57.36%), Postives = 392/537 (73.00%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSN-YGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            S    +Y SL+T  G         QVF KTA +KGN+VA+K++N  ++ E T+++L ++K ++D+ N+H+ RF+G C +P +  ++ EYCP+GSL+D+LENE I LDWMFR SL  DIV+GM++LH+   G HG+LKSSNCVVD RFVLK+TD+GL   R+ + E       H  + K LWT+PE+LR  + P  G+  GDVYSF II QEI  R GVF V+  D   PKEI+E V   +  PFRPS+D +     +L +++++ W EDP  RP F  I+ ++RK +K + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP  NG+ HARE+ARM L  L A+  F I HRP  QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  L+IH+S  T  VL+ F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  530 SGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQG-----HTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLS-PKEIIERVTRGEQPPFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNK-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050

HSP 2 Score: 166.392 bits (420), Expect = 3.388e-41
Identity = 134/500 (26.80%), Postives = 227/500 (45.40%), Query Frame = 2

Query:  275 KLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES---STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYID----DKS----YSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF-------TGLNPR-PWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGS--LCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
            ++GP  +LAL R+   K + +L     +++++    S   + V               +     F+GP  + S   + R +   +   L++ G        KD  +Y   TR   +H  L +F+  L +   W    H+ + V Y D    D+         +   +E +    N++ E  + D     ++   L+ +    RVI IC +    R +ML A++  L   ++VF H+D+F        G  PR PW   +  D  +   R AF++  I+  K P N EY        L+ +A +K+NF+      N +  SF++ ++LY  A+ +  A+  T+   + IT  MWNR+F G    +KID  G+R +DFSL+D+DP++G F+ V  +NG+++    +    + W      PP D PKC FD     C +D  ST  +     +   V  +I  FF YR+++ + EL +  W + WE L      +H +S  SR
Sbjct:   50 RVGPAVELALGRV---KARPDL--LPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTA-HWRVPLLTAGAPALGIGVKD--EYALTTRTGPSHVKLGDFVTALHRRLGW---EHQAL-VLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQ-EFVEGDPDHYTKL---LRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPW---ERDDGQDRRARQAFQAAKIITYKEPDNPEYLE--FLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSR 526

[Close]

BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 609.372 bits (1570), Expect = 0.000e+0
Identity = 312/551 (56.62%), Postives = 392/551 (71.14%), Query Frame = 2

Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            H+G+ S         SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RFIG C++P +  +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++    HG LKSSNCVVDSRFVLK+TD+GL   R      S  EP  SH  Y K LWT+PE+L    LP  G  K DVYSFAII QEI  R G F ++  D   PKEIV+ V++ +   FRPS+D     + +L+ ++++ W +DP  RPDF  IK  +R+ +K  E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HA EIARM L  L A+  F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S +T + L     F +  RG+VEMKGKGK  TYWL GE 
Sbjct:  508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLS-PKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQ 1040

HSP 2 Score: 151.754 bits (382), Expect = 1.150e-36
Identity = 113/431 (26.22%), Postives = 196/431 (45.48%), Query Frame = 2

Query:  458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLKNYK-TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
             +GP  +    ++AR + + +   L++ G     F  K++  Y+ L R   +   L  F+  L   + W  R      + Y+D ++    ++++ + + E L+    +  ++  A       +    + +  R++ ICG  +    I+L A    L   ++VF ++D+F        T    RPW D ++ ++  +++R AF+++L++  + P N EY      N L   ARE +        +N +   FY+ I+LYA  LN+   +  T +   RI   M  R ++G    V +D   +R +DF L+ + D  SG+FQ    Y+G+ E      G+ I W   K  PPLD P CAFD     C K   ST  I    T   F++  +  F  +R+L  + EL +M W I WE L      ++ +   SR
Sbjct:   96 LLGPGCVYPAASVARFA-SHWRLPLLTAGAVASGFAAKNE-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSR 514

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 608.601 bits (1568), Expect = 0.000e+0
Identity = 312/551 (56.62%), Postives = 392/551 (71.14%), Query Frame = 2

Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            H+G+ S         SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RFIG C++P +  +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++    HG LKSSNCVVDSRFVLK+TD+GL   R      S  EP  SH  Y K LWT+PE+L    LP  G  K DVYSFAII QEI  R G F ++  D   PKEIV+ V++ +   FRPS+D     + +L+ ++++ W +DP  RPDF  IK  +R+ +K  E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HA EIARM L  L A+  F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S +T + L     F +  RG+VEMKGKGK  TYWL GE 
Sbjct:   74 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQ 606

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 497.664 bits (1280), Expect = 6.183e-157
Identity = 259/474 (54.64%), Postives = 333/474 (70.25%), Query Frame = 2

Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSG 3274
            H+G+ S         SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RFIG C++P +  +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++    HG LKSSNCVVDSRFVLK+TD+GL   R      S  EP  SH  Y K LWT+PE+L    LP  G  K DVYSFAII QEI  R G F ++  D   PKEIV+ V++ +   FRPS+D     + +L+ ++++ W +DP  RPDF  IK  +R+ +K  E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HA EIARM L  L A+  F I HRP+ QL LRIGVH+G
Sbjct:  508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLS-PKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 963

HSP 2 Score: 151.369 bits (381), Expect = 1.416e-36
Identity = 113/431 (26.22%), Postives = 196/431 (45.48%), Query Frame = 2

Query:  458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLKNYK-TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
             +GP  +    ++AR + + +   L++ G     F  K++  Y+ L R   +   L  F+  L   + W  R      + Y+D ++    ++++ + + E L+    +  ++  A       +    + +  R++ ICG  +    I+L A    L   ++VF ++D+F        T    RPW D ++ ++  +++R AF+++L++  + P N EY      N L   ARE +        +N +   FY+ I+LYA  LN+   +  T +   RI   M  R ++G    V +D   +R +DF L+ + D  SG+FQ    Y+G+ E      G+ I W   K  PPLD P CAFD     C K   ST  I    T   F++  +  F  +R+L  + EL +M W I WE L      ++ +   SR
Sbjct:   96 LLGPGCVYPAASVARFA-SHWRLPLLTAGAVASGFAAKNE-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSR 514

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2g (guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:106025])

HSP 1 Score: 446.817 bits (1148), Expect = 3.280e-137
Identity = 250/560 (44.64%), Postives = 361/560 (64.46%), Query Frame = 2

Query: 1886 HRG---SASNESYMSLVTIS---GVQLENIQNTQVFIK-TALFKGNIVALKKINTGRKFETTKEMLL-DIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENS-NEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKH-VPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPE 3532
            HRG   S  N S  S V  S   G  ++  Q+ ++F     L++GN VAL  I    +    K  +  ++  + +L +++I  F G+C EP +  +V +YC KGSL+D++ N    +DW+F+LS   DIV G+++LH S    HG+LK SNC+VDS   LKL+ FGL   +      S N+E +   + ++ WT+PE+LR +  P  GT +GDVYSFAI+ +++I+++     ++ ++  P+EI+  +K  +  VP RPSL E  G    ++ ++++ WDE P  RP FP IK ++R+    +   +ILD+++ ++E YAN+LE +V +RT+E + EK++ E LL +MLP  V  QLI  +SV  E +E VTI+FSDIVGFT L + S+P+QV++LLN LY+ FD  I++ DVYKVETIGDAYMV SGLP  NG  HA EIA M L  LS    F I H P  +L+LRIG+H+GPV AGVVG  MPRYCLFGDTVN +SRMES+ LPL+IH+S ST   L +   + + +RG + +KGKG+Q T+WL G++ F V P+PE
Sbjct:  535 HRGTPVSRRNVSDTSTVKASADCGSLVKRHQDEELFFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATD--HSELYWTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQAHGPFEDLEAA-PEEIISRIKDPRAPVPLRPSLLEDKG-DGRIVALVRECWDESPELRPIFPSIKKTLREASP-RGHVSILDSMMGKLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWLKGKDGFPV-PLPE 1088

HSP 2 Score: 81.6481 bits (200), Expect = 4.793e-15
Identity = 114/500 (22.80%), Postives = 204/500 (40.80%), Query Frame = 2

Query:  323 KKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVF--YIDDKSYS--DYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGND-LRK-----IAREKYNFSYPKE-ELNYVTTSFYESIMLYALALNDLY-AKNDTLDR----ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEP------PLDTPKCAFDGSLCKKDG--------TSTGLIFGCTTAALFVIGVIGGFFAYR-RLKFQAELKAMNWIIPWESLDTVEKRK--HRQSQISRKDSTVNETL 1723
            K   E  G  N S +  ++ S+  ++    +  F   +  E + A  GP    +   I  ++ + +N  L      G     KD         +    + ++  + + L++  W     ++IGVF     D S+   D  + A E   +     T   + ++SS   ++E L+ +S ++RVII+  +S+  R I+ AAV++ LD  EFVFI   L   L    W +  + D+V       + S+ ++        +   IG+D  RK     + R  +  S   E +++  +   +++++LYA  + ++  A+ D  D      T      T  G   PV +D++G R  D+S++ L         + F +     Y   +     W N+ N        P   P C F   LCK           T T +I   T   L     I G   +R R K Q+      W I ++S+  + + K  HR + +SR++ +   T+
Sbjct:   75 KLNSEPVGLGNVSWEFTYTNSTCSAKES--LAVFIDQVQKEHISALFGPACPEAAEVIGLLA-SEWNIPLFDF--VGQMAALKDHFWCDTCVTLVPPKQEISAVLRESLRYLGW-----EHIGVFGGSSADSSWEQVDEMWGAVEDGLQFHFNITASMRYNSSSSDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLGLDTGEFVFI---LLQQLEDSFWKEVLTKDKVIR-FPKVYESVFLIA----PSAYGGGIGDDGFRKQVSQELRRPPFQSSITSEDQVSPYSAYLHDALLLYAQTVEEMRKAEKDFRDGRQLISTLRAGQVTLQGITGPVLLDSQGKRHVDYSVYALQESGNRSLFLPFLH-----YDSFQKVIRPWRNDSNTSWPHGSLPEYKPGCGFHNDLCKTKPPTVAGMTVTVTAVIPTVTFLVLASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSITLLPQHKLSHRGTPVSRRNVSDTSTV 551

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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18910|ANPRA_RAT (Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus OX=10116 GN=Npr1 PE=1 SV=1)

HSP 1 Score: 622.083 bits (1603), Expect = 0.000e+0
Identity = 309/537 (57.54%), Postives = 392/537 (73.00%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGC-HGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            S    +Y SL+T  G         QVF KTA +KGN+VA+K++N  ++ E T+++L ++K ++D+ N+H+ RF+G C +P +  ++ EYCP+GSL+D+LENE I LDWMFR SL  DIV+GM++LH+   C HG+LKSSNCVVD RFVLK+TD+GL   R+ + E       H  + K LWT+PE+LR  + P  G+  GDVYSF II QEI  R GVF V+  D   PKEI+E V   +  PFRPS+D +     +L +++++ W EDP  RP F  I+ ++RK +K + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP  NG+ HARE+ARM L  L A+  F I HRP  QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S  T  VL+ F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  530 SGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQG-----HTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLS-PKEIIERVTRGEQPPFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNK-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050

HSP 2 Score: 171.014 bits (432), Expect = 8.511e-42
Identity = 136/500 (27.20%), Postives = 229/500 (45.80%), Query Frame = 2

Query:  275 KLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES---STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYID----DKS----YSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF-------TGLNP-RPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGS--LCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
            ++GP  +LALAR+   K + +L     +++++    S   + V               +     F+GP  + S   + R +   +   L++ G        KD  +Y   TR   +H  L +F+  L +   W    H+ + V Y D    D+         +   +E +    N++ E  + D     ++   L+ +    RVI IC +    R +ML A+   L   ++VF H+D+F        GL P +PW   +  D  + S R AF++  I+  K P N EY        L+ +A +K+NF+      N +  SF++ ++LY  A+ +  A+  T+   + IT  MWNR+F G    +KID  G+R +DFSL+D+DP++G F+ V  YNG+++    +    + W      PP D PKC FD     C +D  ST  +     +   +  +I  FF YR+++ + EL +  W + WE L      +H +S  SR
Sbjct:   50 RVGPAVELALARV---KARPDL--LPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTA-HWRVPLLTAGAPALGIGVKD--EYALTTRTGPSHVKLGDFVTALHRRLGW---EHQAL-VLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQ-EFVEGDPDHYPKL---LRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPW---ERGDGQDRSARQAFQAAKIITYKEPDNPEYLE--FLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYW--PLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSR 526

[Close]

BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18293|ANPRA_MOUSE (Atrial natriuretic peptide receptor 1 OS=Mus musculus OX=10090 GN=Npr1 PE=1 SV=2)

HSP 1 Score: 621.313 bits (1601), Expect = 0.000e+0
Identity = 308/537 (57.36%), Postives = 392/537 (73.00%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSN-YGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            S    +Y SL+T  G         QVF KTA +KGN+VA+K++N  ++ E T+++L ++K ++D+ N+H+ RF+G C +P +  ++ EYCP+GSL+D+LENE I LDWMFR SL  DIV+GM++LH+   G HG+LKSSNCVVD RFVLK+TD+GL   R+ + E       H  + K LWT+PE+LR  + P  G+  GDVYSF II QEI  R GVF V+  D   PKEI+E V   +  PFRPS+D +     +L +++++ W EDP  RP F  I+ ++RK +K + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP  NG+ HARE+ARM L  L A+  F I HRP  QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  L+IH+S  T  VL+ F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  530 SGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQG-----HTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLS-PKEIIERVTRGEQPPFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNK-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050

HSP 2 Score: 166.392 bits (420), Expect = 2.370e-40
Identity = 134/500 (26.80%), Postives = 227/500 (45.40%), Query Frame = 2

Query:  275 KLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES---STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYID----DKS----YSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF-------TGLNPR-PWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGS--LCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
            ++GP  +LAL R+   K + +L     +++++    S   + V               +     F+GP  + S   + R +   +   L++ G        KD  +Y   TR   +H  L +F+  L +   W    H+ + V Y D    D+         +   +E +    N++ E  + D     ++   L+ +    RVI IC +    R +ML A++  L   ++VF H+D+F        G  PR PW   +  D  +   R AF++  I+  K P N EY        L+ +A +K+NF+      N +  SF++ ++LY  A+ +  A+  T+   + IT  MWNR+F G    +KID  G+R +DFSL+D+DP++G F+ V  +NG+++    +    + W      PP D PKC FD     C +D  ST  +     +   V  +I  FF YR+++ + EL +  W + WE L      +H +S  SR
Sbjct:   50 RVGPAVELALGRV---KARPDL--LPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTA-HWRVPLLTAGAPALGIGVKD--EYALTTRTGPSHVKLGDFVTALHRRLGW---EHQAL-VLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQ-EFVEGDPDHYTKL---LRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPW---ERDDGQDRRARQAFQAAKIITYKEPDNPEYLE--FLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSR 526

[Close]

BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16066|ANPRA_HUMAN (Atrial natriuretic peptide receptor 1 OS=Homo sapiens OX=9606 GN=NPR1 PE=1 SV=1)

HSP 1 Score: 619.772 bits (1597), Expect = 0.000e+0
Identity = 313/557 (56.19%), Postives = 397/557 (71.27%), Query Frame = 2

Query: 1850 DIDPMVAIRNGKHRGS-----ASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGC-HGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            D++P    R+ +  GS         +Y SL+T  G         QVF KTA +KGN+VA+K++N  ++ E T+++L ++K ++D+ N+H+ RF+G C +P +  ++ EYCP+GSL+D+LENE I LDWMFR SL  DIV+GM++LH+   C HG+LKSSNCVVD RFVLK+TD+GL   R++  E       H  Y K LWT+PE+LR  + P  G+  GDVYSF II QEI  R GVF V+  D   PKEI+E V   +  PFRPSL  +     +L  ++++ W EDP  RP F  I+ ++RK ++ + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP  NGR HA E+ARM L  L A+  F I HRP  QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S  T  VL+ F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  514 DVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQG-----HTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLD-LSPKEIIERVTRGEQPPFRPSL-ALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNR-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054

HSP 2 Score: 179.874 bits (455), Expect = 1.698e-44
Identity = 122/429 (28.44%), Postives = 208/429 (48.48%), Query Frame = 2

Query:  458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLK---NYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT-----GLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDG--SLCKKDGTSTGLIFGCTTAALFVIGV-IGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
            F+GP  + +   + R +   +   L++ G     F  KD  +Y   TR   ++  L +F+  L +   W  R    +  +   D+ +   F+  + +  R++   N   +  +     L      L+ +    RVI IC +    R +ML A+E  L   ++VF H+D+F      G  P P    +  D  + S R AF++  I+  K P N EY        L+ +A E++NF+     +N +  SF++ ++LY  A+ +  A   T+   + IT  MWNR+F G    +KID+ G+R +DFSL+D+DP++G F+ V  YNG+++    + G+ + W      PP D PKC FD     C +D  ST  +      +L ++G+ I  FF YR+++ + EL +  W + WE ++     +H +S  SR
Sbjct:  113 FLGPGCVYAAAPVGRFT-AHWRVPLLTAGAPALGFGVKD--EYALTTRAGPSYAKLGDFVAALHRRLGW-ERQALMLYAYRPGDEEHC--FFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLE--FLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNW--PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLAL-VGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSR 530

[Close]

BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|Q6VVW5|ANPRB_MOUSE (Atrial natriuretic peptide receptor 2 OS=Mus musculus OX=10090 GN=Npr2 PE=1 SV=2)

HSP 1 Score: 609.372 bits (1570), Expect = 0.000e+0
Identity = 312/551 (56.62%), Postives = 392/551 (71.14%), Query Frame = 2

Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            H+G+ S         SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RFIG C++P +  +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++    HG LKSSNCVVDSRFVLK+TD+GL   R      S  EP  SH  Y K LWT+PE+L    LP  G  K DVYSFAII QEI  R G F ++  D   PKEIV+ V++ +   FRPS+D     + +L+ ++++ W +DP  RPDF  IK  +R+ +K  E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HA EIARM L  L A+  F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S +T + L     F +  RG+VEMKGKGK  TYWL GE 
Sbjct:  508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLS-PKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQ 1040

HSP 2 Score: 151.754 bits (382), Expect = 8.042e-36
Identity = 113/431 (26.22%), Postives = 196/431 (45.48%), Query Frame = 2

Query:  458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLKNYK-TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
             +GP  +    ++AR + + +   L++ G     F  K++  Y+ L R   +   L  F+  L   + W  R      + Y+D ++    ++++ + + E L+    +  ++  A       +    + +  R++ ICG  +    I+L A    L   ++VF ++D+F        T    RPW D ++ ++  +++R AF+++L++  + P N EY      N L   ARE +        +N +   FY+ I+LYA  LN+   +  T +   RI   M  R ++G    V +D   +R +DF L+ + D  SG+FQ    Y+G+ E      G+ I W   K  PPLD P CAFD     C K   ST  I    T   F++  +  F  +R+L  + EL +M W I WE L      ++ +   SR
Sbjct:   96 LLGPGCVYPAASVARFA-SHWRLPLLTAGAVASGFAAKNE-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSR 514

[Close]

BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16067|ANPRB_RAT (Atrial natriuretic peptide receptor 2 OS=Rattus norvegicus OX=10116 GN=Npr2 PE=1 SV=1)

HSP 1 Score: 608.986 bits (1569), Expect = 0.000e+0
Identity = 312/550 (56.73%), Postives = 392/550 (71.27%), Query Frame = 2

Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            H+G+ S         SY SL+T  G         Q+F  T  FKGN+VA+K +N  ++ E T+++L ++K ++D+  +H+ RFIG C++P +  +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++    HG LKSSNCVVDSRFVLK+TD+GL   R      S  EP  SH  Y K LWT+PE+L    LP  G  K DVYSFAII QEI  R G F ++  D   PKEIV+ V++ +   FRPS+D     + +L+ ++++ W +DP  RPDF  IK  +R+ +K  E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HA EIARM L  L A+  F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S +T + L     F +  RG+VEMKGKGK  TYWL GE
Sbjct:  508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039

HSP 2 Score: 150.599 bits (379), Expect = 2.018e-35
Identity = 113/434 (26.04%), Postives = 200/434 (46.08%), Query Frame = 2

Query:  458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLK----NYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
             +GP  +    ++AR + + ++  L++ G     F  K++  Y+ L R   +   L  F+  L   + W  R      + Y+D ++    ++++ + + E L+    + + + Y  +    ++       + +  R++ ICG  +    I+L A    L   ++VF ++D+F        T    RPW D ++ ++  +++R AF+++L++  + P N EY      N L   ARE +        +N +   FY+ I+LYA  LN+   +  T +   RI   M  R ++G    V +D   +R +DF L+ + D +SG+FQ    Y+G+ E      G+ I W   K  PPLD P CAFD     C K   ST  I    T   F++  +  F  +R+L  + EL +M W I WE L      ++ +   SR
Sbjct:   96 LLGPGCVYPAASVARFA-SHWHLPLLTAGAVASGFAAKNE-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYTREPGGPEQ---ATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSR 514

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BLAST of Guanylate cyclase vs. TrEMBL
Match: G4V651 (Guanylate cyclase OS=Schistosoma mansoni OX=6183 GN=Smp_142620 PE=3 SV=1)

HSP 1 Score: 964.526 bits (2492), Expect = 0.000e+0
Identity = 506/1053 (48.05%), Postives = 672/1053 (63.82%), Query Frame = 2

Query:  449 VHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTE------GYKADASSLKE---IREK-LKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNP--RPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDG-TSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRT--QTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKII 3547
            V+   GP +  +L   AR S   +N  +V+   AG+  +  DK++Y  LTR+   +  L    G  LK Y WLP     I +    +    +       M    ++   +       YK  + +L +   + ++ LK L   +R+II+C   +  R IML A ++ +   ++ F ++DL +      RPW+ + SS E NE  R A+R+++ V L  P + EY   +   ++R  A   Y+FSY   E+     +F++++ LYALALND  AK  T+     IT  MWNRTF G    V+IDA G+R +D+SL D++P +G+F+ V  Y G+ ++ S + G++I+W N  N+PPL TP C FDGS C        G++       L  + ++ G   YRR KFQAEL+AMNWIIPW++L   EK   R     R++S +                                        SPN  SD  P+  I +     +A+N                   +Q+F +TA +  +IVALK +    + E +K + +++KK+KDLN DHICR IG+C+E  HQ +VYEYCPKGSL+D+LENEQI LDWMF+ SL+QDI RG++YLH  +G HG+LKSSNC+VDSRFVLK+TDFGL  +R      S E  S  +++ +LWT+PE+L     T+    ++KGDVYSFAI+ QEI+YR+GVF + N  + +P  IV+ VK+ +  PFRP+LD ++GCS DL+++I QAWD+DP+ RPDF  IK SMRK++K  +S N+LDNLLSRMEQYANNLE LV QRT +YLEEKK+ EDLLYSMLP+SVA QL +NQ V+AES+E VTIYFSDIVGFTSLSA+STPMQV+ELLNRLYT FD IIENFD YKVETIGDAYMV SGLP  NG  HARE+ARM + FL AIF F IPHRP  +LELRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNGLPLKIHIS  T +VLK+F++FIM+ERG VEMKGKG+Q TYWLHGE+ +IVDP+P  A+I+
Sbjct:  145 VNVIFGPLNDFTLANAARFSTAMYNVPIVA--PAGFAHQLSDKLEYGMLTRVLFTYSDLEWVFGNTLKHYGWLPDQQTPIAIVTTRNVRRREGVVGHTGMAGVFQHLILQKFLVKAAYKLLSVTLDDEFDVTDRFLKRLPDSARIIILCTDPEVVRDIMLEAHKLNMVNGDYAFFNMDLLSSQTKLKRPWYRETSSPEENERARQAYRALMTVTLLKPDSPEY--RTFTEEVRARALRDYDFSYRDSEVTPFIGTFHDAVKLYALALNDALAKGGTITNGTLITQEMWNRTFKGVTGVVRIDANGDRNADYSLLDMNPVTGDFEVVVNYFGNDKSLSTVLGRTIDWINTDNQPPLHTPPCGFDGSECHNSHFIHIGIVGAVVFILLMTMSLVLGIIFYRRAKFQAELRAMNWIIPWDALQVTEKHLRRY----RRESDIR---------------------------------------SPNQSSD--PLRKISSETCTAAAAN-------------------SQMFARTAFYMKSIVALKPLRRQTRMEPSKALSIEVKKVKDLNCDHICRLIGVCLEVPHQCIVYEYCPKGSLQDVLENEQIKLDWMFKFSLMQDICRGVMYLHQIFGPHGNLKSSNCLVDSRFVLKITDFGLPHIRGPPPLES-EVGSFIFHRNLLWTAPELLPDGDTTIYPRESIKGDVYSFAIVCQEIVYRKGVFYIQNFKNCEPDFIVKEVKAHRKPPFRPTLDSLEGCSEDLVQLICQAWDDDPSVRPDFQSIKLSMRKLNKAGDSNNVLDNLLSRMEQYANNLEELVEQRTAQYLEEKKKTEDLLYSMLPRSVAKQLFRNQPVTAESFEMVTIYFSDIVGFTSLSAESTPMQVVELLNRLYTLFDGIIENFDAYKVETIGDAYMVASGLPQRNGNKHAREVARMSIAFLKAIFEFQIPHRPEKRLELRIGIHSGPVCAGVVGQKMPRYCLFGDTVNTSSRMESNGLPLKIHISQQTFDVLKTFKSFIMTERGLVEMKGKGRQKTYWLHGEDCYIVDPIPPGAQIV 1128

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BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8JDN4 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 892.493 bits (2305), Expect = 0.000e+0
Identity = 484/1071 (45.19%), Postives = 669/1071 (62.46%), Query Frame = 2

Query:  464 GPNSIISLGTIARMSGTR-FNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK---------------------SYSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYA-------KNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTG-------LIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPN--SDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKIN-TGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRT-QTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKS--SKHVPFRPSLDE----IDGCS-SDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDP 3523
            GP     L  +AR +    + + +++ G A      +DK +Y  L R+   +  + N +  + + Y WLPR  +N+ + Y+ D                      +  + F      + R+K Y        +   + +RE++       R++++C      R IM+ A E+     E+VF +IDLF+   L  RPW+ +  S+E N +   A+R+++ + L  P ++EY + S  + ++  A++ Y+F YP+EE+N    +F+++++LYALA+ND  A        N +L  IT+ M +RTF G    V I+A G+R +D+SL D+D  + NF  V  Y G+T+ Y L+ GK I+W ++ N PP D PKC FD S CKKD +          L+  C  + L  IGVI     YR+L+ ++EL AMNW I W  L+  E+   R+  ++ + S + E   +   +  +        GN+Q   E    E   L  +PN     D DP +A      +GS    S  S+ TI+GV L  I   Q+F KTA +KGN+VALK+I    ++ E   ++L++IK++KDL +D+I RFIG C++  ++ LV EYCPKGSL+D+LEN+ +NLDWMF+ SL+ DI RGMIYLH ++G HG+LKSSNC+VDSRF LK+ DFGL+ LR  ++    ++  +  Y+  LWT+PE+LR   T P  GT +GDVYSF IIAQEIIYR+GVF + + D  +P++I+E ++       PFRPSL +    +DG     L+ I++  W EDPN RP+F  +K+ + + +K  ESGNILDNLL RMEQY+NNLE LVA+RT +YLEEKK+AE+LLY MLPK VA  L+K +SV+AE ++ VTIYFSDI GFT+LS++STPM+V+ LLN LYT FD IIE +D YKVETIGDAYMVVSGLP  NG  HAREIARM L FL  IF F I H+P+ QL+LRIGVHSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIHIS  T  +L+    F+ +ERGEVEMKGKG Q TYWLHGEND IVDP
Sbjct:   37 GPFCTFCLAAVARYNRYYLYQKPIITSGAAA---NLEDKEEYYNLIRVGPMNFDIENMLLAIFQRYNWLPRQQQNLLIIYVPDDETQLHKQRDETRVTFSRLLRTTIENRFSHQHRYILRVKPYSATNKHFQSEVFRCMREEV-------RLVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFS--DKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSL--ITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVL--IGVI-----YRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTF------GNHQQEGE----EAQPLNPTPNEQQQQDEDPAIA-----PKGSDVVSSNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKELKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEPQDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1071

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BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8HCY1 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 884.404 bits (2284), Expect = 0.000e+0
Identity = 480/1083 (44.32%), Postives = 673/1083 (62.14%), Query Frame = 2

Query:  431 FILDEPVHAFIGPNSIISLGTIARMSGT-RFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSD---------------------YFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAK-------NDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDP---MVAIRNGKHRGSASNE-SYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKIN-TGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLD----EIDGCSSD-LIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKIIQ 3550
             +L + +   +GP    +L  +AR +    + R +++ G  G     +DK +Y  L R+  + + +   +  + + + W PR  + I    + D+   +                     +F   K ++ RL+ Y+    +  +   + +R+++       R++++C      R IM+ A E+     E+VF +IDLF+   L  +PW  +  + E NE    A+R+++ + L  P + EY N S    ++ IA+ KYNF+YP+EE+N    +F+++++LYALA+ND   +       N +L  IT  M NRTF G    V I+A G+R +D+SL D+D  + NF  V  Y G+ + Y L+ GK I+W NE N PP D PKC FD S+CK+D +            L  +  +     YR+L+ ++EL AMNW IPW  L+ +E+         R+ S   + L   D++ ++    +      Q  +++ +    L  NS N  S           +N +H G+A+ E S +S+ TI+GV L  I  TQ+F KTA +KG +VALK ++   ++ E T ++L+++K++KDL +D++ RFIG C++  ++ LV EYCPKGSL+D+LEN+ +NLDWMF+ SL+ DI RGMIYLH N+G HG+LKSSNC+VDSRF LK+ DFGL  LR  +     E+  +  Y+  LWT+PE+LR  T P  GT +GDVYSFAII QEIIYRRGVF + + D  +P+EIVE VK   +  +RP+LD    + D   S+ LI  ++  W EDP  RP F  IK+ + + +K  ESGNILDNLL RMEQY+NNLE LVA+RT  YLEEKK+AE+LLY MLPKSVA  L++ +SV+AE ++ VTIYFSDI GFT+LS++STP++V+ LLN LYT FD IIE +D YKVETIGDAYMVVSGLP  NG  HAREI+RM L FL  I+ F I H+P+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIHIS  T E+L+    F+ + RGEVEMKGKGKQLTYWLHGE D IVDPV  +  + Q
Sbjct:   48 LLLQQKIDLMLGPYCSFALAAVARYNRMPHYRRPILTTG--GVASALRDKAEYFNLIRVGPSFDGVEKMLYLVFQRFNWKPRDVQTILFIELPDEDVKEKRTRDEIGVTQSRILCHGIEKHFVQEKYIVRRLQ-YEMHNAQFKSEIFRVMRDEI-------RLVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFS--QQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSL--ITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMER-----IAAGRRTSESGKDLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVKEISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPVVSNGSLNQ 1111

[Close]

BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8GAT2 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 877.47 bits (2266), Expect = 0.000e+0
Identity = 492/1150 (42.78%), Postives = 698/1150 (60.70%), Query Frame = 2

Query:  230 LEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTR-FNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEM---------MERLKNYKTEGYKADASSLKEIREKL-----KLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLY-------AKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR-------KDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMET------TLLLNSPNSDSDIDPMVAIRNGKHRG--SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKIN-TGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKE-NSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSL-DEIDGCSSD----LIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPES 3535
            + ++N ++M +E   ++ P+ D+A+A  + +         +N +++L  ++S       +I       +L E V   +GP     LG +AR +    + R +++ G  G      +KV+Y  L R+  +HE +   + K+ K Y W PRP + + V    D+  S    S   +         +E++       Y A   + K  R  L     K+L  + R++++C      R IM+ A E+     E+VF +IDLF+   L  RPW     + E N     A+RS++ + L  P + EY N S    ++++A  KYNF+YP+EE+N    +F+++++LYALA+ND          +N +L  +T  M +R+F G    V I+  G+R +D+SL D+D  +G F  V  YNG+ + Y L++ + I+W NE+N PP D P C FD SLCKKD T   L        L     I  F  YR+L+ ++EL  MNW I WE L+  E+   R+  +++       K +T  +     ++K  ++ Q      N+ G+K     +       TL L      ++      I  G  +      + S  S+ TI+GV L  I   Q+F KTA +KG +VALK++N   ++ E T  +L+++K++KDL +D++ RFIG C++P ++ LV EYCPKGSL+D+LEN+ +NLDWMF+LSL+ DI RGMIYLH ++G HG+LKSSNC+VDSRF LK+ DFGL  LR  + E    E+  +  Y+  LWT+PE+LR    PF GT +GDVYSFAII QE+IYR+GVF + + D  +P++IVE V++ ++ PFRP+L +E+     D    L  +++  W EDP  RP F   K+ + + +K  ESGNILDNLL RMEQY+NNLE LVA+RT +Y  EKK+AEDLLY MLPK+VA  L++ ++V+AE ++ V+IYFSDI GFT+LS++STP+QV+ LLN LYT FD IIE +  YKVETIGDAYMVVSGLP  NG  HA EI+RM L FL+ I+ F I H P  QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIHIS +T E+L     F+ + RGEVEMKGKGKQLTYWLHGE D IVDP P +
Sbjct:    1 MSRHNISHMSLE---RVLPVVDVAVASAQSVGL------LSNVTVRLLSNDSEC---DYSIAPVVGMLMLRE-VDLMLGPYCSFCLGAVARYNRYHLYQRPIITSG--GGASVLNNKVEYYNLIRVGPSHEQIEEMLLKIFKHYNWRPRPVQTVLVVGPPDEINSRQHQSESIISDALVMSVAIEKMLTQPNVSYIARRLTYKPGRPHLATQLFKVLEEV-RIVVLCADPDTVRDIMIRAEELGFINGEYVFFNIDLFSSEKLTVRPWRRVNDTAERNSKAFRAYRSLMTITLRKPNSPEYRNFS--RQVKELAYHKYNFTYPEEEVNSFVGAFHDAVLLYALAINDTLREHGSEGIRNGSL--VTEKMKSRSFEGITGTVSINKNGDRNADYSLLDMDKDTGEFAVVAHYNGNKKVYELVKDRQIDWNNEENLPPKDIPTCGFDYSLCKKDLTQMALYAVVVLLVLICFLTILIFVIYRKLRLESELHGMNWRIAWEELEPTERVAARRRSLAQPQPPPPQKQTTNKKKRARLNQKKQQQQQPHWFFANHHGTKRSNRGDPDEAAAETLPLRPSGGGANDSGGGDIGAGDSQSVVQMDSASMESVETIAGVPLSQIPTAQLFAKTAYYKGTLVALKQLNLRNKRIEVTNRLLMEVKRVKDLASDNVVRFIGACLDPPNECLVTEYCPKGSLQDILENDNLNLDWMFKLSLMADICRGMIYLHHSFGSHGNLKSSNCMVDSRFSLKIADFGLQSLRSNKLEYRDKEDGDYSTYRNKLWTAPELLRLPNPPFEGTKEGDVYSFAIICQEVIYRKGVFFLSDSDFIEPQDIVERVRTPQNPPFRPALVEEMSDLEPDRTAALTAMVELCWHEDPGARPTFNAAKSRISRFNKTAESGNILDNLLKRMEQYSNNLESLVAKRTDQYQVEKKKAEDLLYCMLPKAVATTLMRGEAVTAEWFDSVSIYFSDICGFTALSSESTPLQVVTLLNDLYTLFDRIIEQYSCYKVETIGDAYMVVSGLPERNGNRHAGEISRMALSFLNNIYSFEIRHMPGVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISATTHELLTDIGNFVTTVRGEVEMKGKGKQLTYWLHGEGDKIVDPPPAA 1130

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BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A267FJR9 (Guanylate cyclase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025214g3 PE=3 SV=1)

HSP 1 Score: 872.848 bits (2254), Expect = 0.000e+0
Identity = 464/946 (49.05%), Postives = 626/946 (66.17%), Query Frame = 2

Query:  776 EGYKADASSLKEIREKL-KLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYA-------KNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTG-------LIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPN--SDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKIN-TGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRT-QTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKS--SKHVPFRPSLDE----IDGCS-SDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDP 3523
            EG + D+S+    R  L + +S+   V+++C      R IM+ A E+     E+VF +IDLF+   L  RPW+ +  S+E N +   A+R+++ + L  P ++EY + S  + ++  A++ Y+F YP+EE+N    +F+++++LYALA+ND  A        N +L  IT+ M +RTF G    V I+A G+R +D+SL D+D  + NF  V  Y G+T+ Y L+ GK I+W ++ N PP D PKC FD S CKKD +          L+  C  + L  IGVI     YR+L+ ++EL AMNW I W  L+  E+   R+  ++ + S + E   +   +  +        GN+Q   E    E   L  +PN     D DP +A      +GS    S  S+ TI+GV L  I   Q+F KTA +KGN+VALK+I    ++ E   ++L++IK++KDL +D+I RFIG C++  ++ LV EYCPKGSL+D+LEN+ +NLDWMF+ SL+ DI RGMIYLH ++G HG+LKSSNC+VDSRF LK+ DFGL+ LR  ++    ++  +  Y+  LWT+PE+LR   T P  GT +GDVYSF IIAQEIIYR+GVF + + D  +P++I+E ++       PFRPSL +    +DG     L+ I++  W EDPN RP+F  +K+ + + +K  ESGNILDNLL RMEQY+NNLE LVA+RT +YLEEKK+AE+LLY MLPK VA  L+K +SV+AE ++ VTIYFSDI GFT+LS++STPM+V+ LLN LYT FD IIE +D YKVETIGDAYMVVSGLP  NG  HAREIARM L FL  IF F I H+P+ QL+LRIGVHSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIHIS  T  +L+    F+ +ERGEVEMKGKG Q TYWLHGEND IVDP
Sbjct:  244 EGRQNDSSTSSLYRRILHERVSTKFSVVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFS--DKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSL--ITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVL--IGVI-----YRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTF------GNHQQEGE----EAQPLNPTPNEQQQQDEDPAIA-----PKGSDVVSSNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKELKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEPQDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1163

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BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 625.165 bits (1611), Expect = 0.000e+0
Identity = 317/540 (58.70%), Postives = 403/540 (74.63%), Query Frame = 2

Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            RGS    +Y SL+T  G       N QVF KTA FKGNIVA+K +N  ++ E T+++L ++K ++D+ NDH+ RFIG C++P +  +V EYCP+GSL+D+LENE I LDWMF+ SLI DIV+GM +LH S    HG+LKSSNCVVD+RFVLK+TD+GL+  R      S+ E +H YY + LW +P++LR    P  GT KGD+YSF II QE+  RRGVF ++  DS  PKEIV+ V   +    RP+++     S +L +++++ W E+P  RP+F  IK  +RK ++ + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HAREIARM L  L A+  F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ ++L+ F  F +  RG+VEMKGKGK  TYWL GE+
Sbjct:  548 RGS----NYGSLLTADG-------NFQVFAKTAYFKGNIVAIKYVNR-KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT----ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNR-EVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGES 1068

HSP 2 Score: 142.51 bits (358), Expect = 6.725e-34
Identity = 108/414 (26.09%), Postives = 186/414 (44.93%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK-SYSDYFYSAKEMMERLKNYKTEG----YKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKND---TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
            AFIGP    +   +   + T +   +++ G     F  +    Y  +T     H+ L  F   + + + W     ++  + + D K    + +++ + +   LK          ++ D+  +    E L+ +    RV+ +C +    R +M+   +  L   EFVFI+ID+F    T    +PW    + DE+ +    + + +L  + P N EY +  +  DL+  A++ +NF+     +N ++  FY+ +MLY  ALN+  A++    +   IT  MWNRT+ G    V+ID  G+R +DF+L+D+ D  S  FQ V  YNG+ +    + G +  W       P D P C F  D   C     +   +       + VI      F YR+LK + EL A  W I WE +
Sbjct:  126 AFIGPGCDYTSSPVGLFT-THWGLPMITAGAPAVGFSDRSDA-YTSITNTGPTHKKLGEFALHICRHFGW----SQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVN-YSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVK-ILTYREPQNPEYKDFVM--DLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDM 527

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Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            RGS    +Y SL+T  G       N QVF KTA FKGNIVA+K +N  ++ E T+++L ++K ++D+ NDH+ RFIG C++P +  +V EYCP+GSL+D+LENE I LDWMF+ SLI DIV+GM +LH S    HG+LKSSNCVVD+RFVLK+TD+GL+  R      S+ E +H YY + LW +P++LR    P  GT KGD+YSF II QE+  RRGVF ++  DS  PKEIV+ V   +    RP+++     S +L +++++ W E+P  RP+F  IK  +RK ++ + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HAREIARM L  L A+  F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ ++L+ F  F +  RG+VEMKGKGK  TYWL GE+
Sbjct:  548 RGS----NYGSLLTADG-------NFQVFAKTAYFKGNIVAIKYVNR-KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT----ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNR-EVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGES 1068

HSP 2 Score: 142.51 bits (358), Expect = 6.725e-34
Identity = 108/414 (26.09%), Postives = 186/414 (44.93%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK-SYSDYFYSAKEMMERLKNYKTEG----YKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKND---TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
            AFIGP    +   +   + T +   +++ G     F  +    Y  +T     H+ L  F   + + + W     ++  + + D K    + +++ + +   LK          ++ D+  +    E L+ +    RV+ +C +    R +M+   +  L   EFVFI+ID+F    T    +PW    + DE+ +    + + +L  + P N EY +  +  DL+  A++ +NF+     +N ++  FY+ +MLY  ALN+  A++    +   IT  MWNRT+ G    V+ID  G+R +DF+L+D+ D  S  FQ V  YNG+ +    + G +  W       P D P C F  D   C     +   +       + VI      F YR+LK + EL A  W I WE +
Sbjct:  126 AFIGPGCDYTSSPVGLFT-THWGLPMITAGAPAVGFSDRSDA-YTSITNTGPTHKKLGEFALHICRHFGW----SQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVN-YSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVK-ILTYREPQNPEYKDFVM--DLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDM 527

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BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539])

HSP 1 Score: 591.652 bits (1524), Expect = 0.000e+0
Identity = 305/549 (55.56%), Postives = 393/549 (71.58%), Query Frame = 2

Query: 1868 AIRNGKHRGSAS--NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            A+R    R + S    +Y SL+T+ G       N Q++ KT  +KGNI A+K +N  ++ E T+++L ++K ++D+ N+H+ RFIG C++  +  ++ EYCP+GSL+DL+E E I LDWMFR SLI DIV+GM +LH S    HG+LKSSNC+VDSRFVLK+TD+GL   R+     S  E +H YY + LWT+PE++R +     GT KGDVYSF II QE+   +GVF +D+     PKEIVE V   +    RP L      S +L +++++ W ED N RPDF  IK  + K ++G  S NILDNLLSRMEQYANNLE LV +RTQ Y EEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT++SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H  EIARM L  L A++ F I HRP+ QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S +T  VL+ F  F +  RG++EMKGKG+  TYWL GE+
Sbjct:  515 ALRRACSRLTLSLRGSNYGSLLTLEG-------NVQIYAKTCYYKGNITAIKYVNK-KRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFRK----ESYLEDTHAYYARKLWTAPELMRDENRQPCGTQKGDVYSFGIILQELALLKGVFYLDS-PPFSPKEIVEHVAEGRWPYLRPLLC-TQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHKNNRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDIEMKGKGRMRTYWLLGES 1048

HSP 2 Score: 103.219 bits (256), Expect = 9.116e-22
Identity = 107/419 (25.54%), Postives = 182/419 (43.44%), Query Frame = 2

Query:  173 GKKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES--------STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSA-----KEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF-TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALN---DLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQ 1369
            G+   P    +A+++   N E             ++GP  + AL   EK+     L     Y ++L FS S         +V+    +  +F +    +P  AFIGP    +   +AR + T +   +V+ G     F       Y  +T     H+ L  F+ ++   + W    HK   V + D K+     Y A      EM       K   +  D   L    + +  +S   RV+ +C      R +M+   + +L   E+VF  IDLF   L  RP       D  +E+ + AF+S+ I+  + P N EY      + +++ A++++NFS     +N +   F++ ++LY+ ALN   D          +T  MWNRTF+G    V++D  G+R  DF+L+D+ D +SG ++
Sbjct:   17 GRTSVPPNITLAIILPKQNTEYPWA-------WPRVGPALNWAL---EKVNSDPTL--LPGYHMQLVFSSSENKEGLCSDSVAPLVAVDLKFAH----DP-WAFIGPGCDYASSPVARFT-THWEVPMVTAGAPALGFNM-----YSSITNTGPTHKKLGEFVVRMHHNFGW----HKYAMVMFHDKKNDDRPCYFAVEGPYTEMTADNITAKDMVFNEDDEPLS-YADLINGISQRGRVVYVCCKWDTFRKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPWARGDADDEAAKQAFKSVKIMTYREPQNPEY--KHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYE 405

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BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 576.244 bits (1484), Expect = 0.000e+0
Identity = 300/540 (55.56%), Postives = 384/540 (71.11%), Query Frame = 2

Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            RGS    +Y SL+T  G       N QVF KTA FKGNIVA+K +N  ++ E T+++L ++K ++D+ NDH+ RFIG C++P +  +V EYCP+GSL                      ++ GM +LH S    HG+LKSSNCVVD+RFVLK+TD+GL+  R      S+ E +H YY + LW +P++LR    P  GT KGD+YSF II QE+  RRGVF ++  DS  PKEIV+ V   +    RP+++     S +L +++++ W E+P  RP+F  IK  +RK ++ + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HAREIARM L  L A+  F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ ++L+ F  F +  RG+VEMKGKGK  TYWL GE+
Sbjct:  528 RGS----NYGSLLTADG-------NFQVFAKTAYFKGNIVAIKYVNR-KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSL----------------------VLSGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT----ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNR-EVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGES 1026

HSP 2 Score: 142.124 bits (357), Expect = 8.557e-34
Identity = 108/414 (26.09%), Postives = 186/414 (44.93%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK-SYSDYFYSAKEMMERLKNYKTEG----YKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKND---TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
            AFIGP    +   +   + T +   +++ G     F  +    Y  +T     H+ L  F   + + + W     ++  + + D K    + +++ + +   LK          ++ D+  +    E L+ +    RV+ +C +    R +M+   +  L   EFVFI+ID+F    T    +PW    + DE+ +    + + +L  + P N EY +  +  DL+  A++ +NF+     +N ++  FY+ +MLY  ALN+  A++    +   IT  MWNRT+ G    V+ID  G+R +DF+L+D+ D  S  FQ V  YNG+ +    + G +  W      P  D P C F  D   C     +   +       + VI      F YR+LK + EL A  W I WE +
Sbjct:  106 AFIGPGCDYTSSPVGLFT-THWGLPMITAGAPAVGFSDRSDA-YTSITNTGPTHKKLGEFALHICRHFGW----SQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVN-YSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVK-ILTYREPQNPEYKDFVM--DLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPGGFIPP--DMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDM 507

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Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            RGS    +Y SL+T  G       N QVF KTA FKGNIVA+K +N  ++ E T+++L ++K ++D+ NDH+ RFIG C++P +  +V EYCP+GSL+D+LENE I LDWMF+ SLI DIV+GM +LH S    HG+LKSSNCVVD+RFVLK+TD+GL+  R      S+ E +H YY + LW +P++LR    P  GT KGD+YSF II QE+  RRGVF ++  DS  PKEIV+ V   +    RP+++     S +L +++++ W E+P  RP+F  IK  +RK ++ + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV                       ETIGDAYMVVSGLP  NG+ HAREIARM L  L A+  F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ ++L+ F  F +  RG+VEMKGKGK  TYWL GE+
Sbjct:  567 RGS----NYGSLLTADG-------NFQVFAKTAYFKGNIVAIKYVNR-KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT----ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNR-EVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQV-----------------------ETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGES 1064

HSP 2 Score: 142.51 bits (358), Expect = 7.103e-34
Identity = 108/414 (26.09%), Postives = 186/414 (44.93%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK-SYSDYFYSAKEMMERLKNYKTEG----YKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKND---TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
            AFIGP    +   +   + T +   +++ G     F  +    Y  +T     H+ L  F   + + + W     ++  + + D K    + +++ + +   LK          ++ D+  +    E L+ +    RV+ +C +    R +M+   +  L   EFVFI+ID+F    T    +PW    + DE+ +    + + +L  + P N EY +  +  DL+  A++ +NF+     +N ++  FY+ +MLY  ALN+  A++    +   IT  MWNRT+ G    V+ID  G+R +DF+L+D+ D  S  FQ V  YNG+ +    + G +  W      P  D P C F  D   C     +   +       + VI      F YR+LK + EL A  W I WE +
Sbjct:  145 AFIGPGCDYTSSPVGLFT-THWGLPMITAGAPAVGFSDRSDA-YTSITNTGPTHKKLGEFALHICRHFGW----SQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVN-YSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVK-ILTYREPQNPEYKDFVM--DLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPGGFIPP--DMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDM 546

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006352.1 (pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 gene:ENSPMAG00000005587.1 transcript:ENSPMAT00000006352.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 607.831 bits (1566), Expect = 0.000e+0
Identity = 318/544 (58.46%), Postives = 394/544 (72.43%), Query Frame = 2

Query: 1883 KHRGSASNESYMSLVTISGVQLENIQN-TQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLE-DLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCS-SDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            K R SA ++  +S+   S   L   Q   Q+F KT  ++GN+VA+K IN  +K E T+E+L ++K ++D+ N+H+ RF+G C++P +  +V EYCP+GSL+ D+LENE I LDW+FR SLI DIV+GM++LH S  G HG LKSSNCVVDSRFVLK+TD+GL   R      S  E  H  Y K LWT+PE+LR +  P  GT KGDVYS  II QEI  R G F V+  D   PKEIV+ VK+ +   FRPS DE   C   +L  ++++ W EDP  RPDF  IK  + K +K + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ +A+EIARM L  L A+  F I HR   +L+LRIG+H+GPVCAGVVG KMPR+CLFGDTVNT+SRMESNG  LKIH+S +T EVL  F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  286 KARRSAGSKLTLSMRGSSCGSLLTTQGRNQMFAKTGYYRGNLVAIKPINK-KKIELTREVLFELKHMRDVLNEHLTRFVGACIDPPNICIVTEYCPRGSLQQDILENESITLDWVFRYSLINDIVKGMLFLHNSVIGSHGSLKSSNCVVDSRFVLKITDYGLASFRSC----SECEDMHSLYAKKLWTAPELLRLEHPPPQGTQKGDVYSLGIILQEIALRNGTFYVEGMD-LSPKEIVQKVKNGQRPYFRPSTDE--SCHIEELGLLMQRCWAEDPAERPDFSQIKMLIHKFNK-ENSTNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAETLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLNAKEIARMSLALLDAVKTFKIRHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWLLGE 820

HSP 2 Score: 148.673 bits (374), Expect = 1.106e-36
Identity = 99/348 (28.45%), Postives = 170/348 (48.85%), Query Frame = 2

Query:  851 VIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT--------GLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQG--------SKEKIEMETTLLL 1828
            V+  C ++   R  M+ A    +   ++VF ++D F+          + +PW   K  DE +E  + A+++++I+  + P N EY +  +   L+K A+E++NF+     +N +  SFY++IM+Y  ALN   +    +     IT +MWNRT+ G      ID  G+R +DFSL+DL D  +G F  V  Y+G++     + G  I+W       P D P C F+   C   G ST  +     + + +I  +  F  YR+LK + EL +M W + WE++      K R+S  S+   ++  +          ++Q   K+G Y+G        +K+KIE+   +L 
Sbjct:    6 VVYFCCSAAVFRQTMVQAHAEGMTAGDYVFFYVDPFSESLSESNVSESRKPW---KRGDEFDEQAKEAYKAVMIISYREPQNIEYKDFVV--KLKKRAKEQFNFTIEDTLMNLIAGSFYDAIMMYTAALNKTLSSGGGVHDGHAITKHMWNRTYRGVTGEFTIDRNGDRETDFSLWDLTDMNTGEFNVVLSYDGASSKLIEVPGLEIQWPG--GSIPKDVPLCGFENEACISGGFSTMEVLMIVFSLILLIVAVSSFLIYRKLKLEKELASMLWRLRWENIQVSSLEKARRSAGSKLTLSMRGSSCGSLLTTQGRNQMFAKTGYYRGNLVAIKPINKKKIELTREVLF 346

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943])

HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0
Identity = 287/511 (56.16%), Postives = 372/511 (72.80%), Query Frame = 2

Query: 1994 KGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKI---DKGKESG---NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            +GN+V +  IN  +K E T++ML ++K ++D+ N+H+ RF+G C++  +  ++ EYCP+GSL+D+LENE I+LDWMFR SL+ DIV+GM+YLHS+  G HG+LKSSNCVVDSRFVLK+TD+GL+ +R   K +S    S  Y++K LWT+PE+LR + +   GT KGDVYSFAII QEI  R G F ++  +    KEIV+ VK  +    RP++D   G S +L  ++++ W E+   RPDF  IK  ++K    D G ES     ILDNLLSRMEQYANNLE LV +RTQ YLEEK +AE LLY +LP SVA QL + ++V AE+++ VTIY SDIVGFT++SA STPMQV+  LN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG  HA E+ARM L  LSA+  F I HRP  +L LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRME+ G   +IH+S +T  +L  +  F++   G+V++KGKG   TYWL GEN
Sbjct:    1 QGNLVEIPFINR-KKIELTRQMLFELKHMRDVQNEHLTRFVGACIDVPNICIITEYCPRGSLQDILENESISLDWMFRYSLMHDIVKGMLYLHSSVIGSHGNLKSSNCVVDSRFVLKITDYGLSSVRAHSKADS----SANYFEKRLWTAPELLRLEEVAPRGTQKGDVYSFAIILQEIALRSGPFYLE-ANHLTAKEIVQRVKLGEWPYLRPTVDP-GGHSEELGHLMQRCWAEESTERPDFHQIKILLQKFSSQDDGPESPPAFTILDNLLSRMEQYANNLEELVEERTQAYLEEKGKAEALLYQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVHNGTRHAIEVARMALALLSAVRCFHIRHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLGEN 504

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008976.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008976.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 453.366 bits (1165), Expect = 1.161e-144
Identity = 297/798 (37.22%), Postives = 430/798 (53.88%), Query Frame = 2

Query: 1172 FYESIMLYALALNDLYAKND------TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLI----EGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTS---TGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMN---WIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPS-HEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYR--RGVFAVDNCDSKDPKEIVESVKSSKHV-PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
             +++ +LYA+A+ +L  +         + R         F G    V ID  G R  D+++FDL  K     ++   +    T+  I    E + + W + +  PP D P+C F G LC++   S     L+   +  +L VIG +  F  Y  ++ ++  ++M+   W I +E +  V                    L+N               G+Y+ S +++        N  N   D+            G+   E  + +   + V L+ ++ T         K N  ALK           +EML          ++++  F G+CVE  +  +V +YC KGSL+D+L+     LDWMF+ S   DIV GMI+LH S    HG+LK S C++DSR  +KLT FG+   R  +K  + +  +   ++ ++ WT+PE+LR + LP  GT KGDV+SFAI+ +E+IY    G +   +    +PK+I++ V+    V P RP L E   C   +  +I+Q WDE  + RPDF  +   +R +   +   NILDN++S++E+YAN+LE +V  RT +   EKK+ + LL S+LP  V  QL   ++V  E YE VTI+F DIVGFT++SA STP++VI LLN LY   D II+ +DVYKVETIGDAYMV SGLP  NG  H  EIA M L FLS+I  F I H P  QL+LRIG++SGPV AGVVG+ MPRYCLFGDTVN +SRMES G PL IH+S +T  +LK    + + ERG + +KGKG QLTYWL G+
Sbjct:    4 LHDAGILYAMAVRELLRQGGNPRDGRAVIRTIRGSNKIKFYGASGQVSIDVNGERFLDYAVFDLQKKQTATGEMRIASKRYFTFQTINFTPEYQKMGWPDGR--PPSDMPECGFTGELCQEAPISEPDLALVLVGSILSLIVIGTV-AFLTYLVVQSRSLQESMDTTWWKINFEDITLV-------------------PLVN---------------GSYRSSSKQVSG------NQSNVHHDV-----------HGTDRVEIPIGIYQGNQVALKFLERTH----PPDLKSNRFALK----------MREML----------HENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINNLGSFFIELYWTAPELLRMEDLPVNGTPKGDVFSFAILMREVIYHEDEGPYVGIHL---EPKDIIDQVRDGIAVPPLRPLLTE--RCEPRIQALIRQCWDESADRRPDFSSVSRMLR-LASPEGDMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 717

[Close]

BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008942.1 (pep scaffold:Pmarinus_7.0:GL476454:59555:94399:-1 gene:ENSPMAG00000008084.1 transcript:ENSPMAT00000008942.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 446.432 bits (1147), Expect = 4.558e-138
Identity = 245/526 (46.58%), Postives = 345/526 (65.59%), Query Frame = 2

Query: 1967 QVFIKTALFKGNIVALKKINTGRKFE-TTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSK-HVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKID-KGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPE 3532
            ++F    +++GN VALK +   R  +  +K +L +++ +++L ++++  F G+CVE  +  +V +YC KGSL+D+L+     LD MF+ S   DIV GMI+LH S    HG+LK S C++DSR  +KLT FG+   R   K+    + +++   ++ WTSPE+LR +  P  GT KGDV+SF ++ +E+IY          D  +PKEI++ V+  K   P RP L E   C   +  +I++ WDE P+ RPDF  I   +R    +G  S  ILDN++S++E+YAN+LE +V  RT +   EKK+ + LL S+LP  V  QL   ++V  E +EQVTI+F DIVGFT++SA S+P++VI LLN LY   D II+ +DVYKVETIGDAYMV SGLP  NG  H  EI+ M L FLS+I  F I H P  QL++RIGV+SG V AGVVG+ MPRYCLFGDTVN +SRMES G PL+IH+S ST  +LKS   + + ERG +++KGKG QLTYWL+G+  F + P+P+
Sbjct:  543 KMFTPLGIYQGNQVALKFLQRTRPPDLKSKTLLKELQMLRELRHENLVVFFGVCVEMPNICIVTQYCRKGSLKDVLKTSDFELDLMFKTSFAYDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRH-GKKGKIMDVNNQDIAELFWTSPELLRMEIFPVNGTPKGDVFSFGVLMREMIYHEDEGPYVGVD-MEPKEIIDQVREGKCSPPLRPLLTE--RCEPRIQALIQRCWDESPDRRPDFHSIARMLRSASPEGHRS--ILDNMVSKLEKYANHLEEVVEDRTAQLESEKKKTDRLLSSLLPSVVVEQLKAGKTVQPEHFEQVTIFFCDIVGFTAMSAISSPLEVITLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEISIMSLHFLSSIINFRIRHLPKEQLKIRIGVNSGSVVAGVVGNTMPRYCLFGDTVNVASRMESTGYPLRIHVSESTASLLKSIGGYELVERGAIQLKGKGSQLTYWLNGKFGFHM-PLPD 1061

HSP 2 Score: 55.0694 bits (131), Expect = 1.142e-7
Identity = 59/259 (22.78%), Postives = 109/259 (42.08%), Query Frame = 2

Query:  773 TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKY------NFSYPKEELNYVTTSFYESIMLYALALNDLYAKND------TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPK--SGNFQQVGFYNGSTETYSLI-EGKSIEWGNEKNEPPLDTPKCAFDGSLCKK 1504
            T   K D S     R+ L  +S+ +R++I+   S+  R ++L A  + L   +F+F+ +  F       ++   +++ ++     A   +++  +     Y +S     L+++ R         N S  KE   Y     +++ +LYA+A+ +L            + R         F G    V ID  G R  D+++F+L  K  S  F  V  ++    + S   E + + W   +  PP D P C F G LC++
Sbjct:  190 TARIKYDTSDKVLHRQNLLDISTKARIVILICGSEEAREVLLEAQSLGLATGKFIFLVVQQFED----SFWKSVAAERLDTQTLQALEPVMLFTI---KAYGSSDYELFLQEVRRRLLGPPFYSNLSSDKEVSPY-AAYLHDAAILYAMAVRELLRHGGNPRDGRAIVRTIKGSTKVKFYGVSGQVNIDVNGERFLDYAVFNLQKKGNSSQFLPVMVFDTFQGSISFTPEYQKMVW--PEGGPPNDMPICGFLGELCQE 438

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008986.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:128493:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008986.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 430.639 bits (1106), Expect = 2.496e-137
Identity = 235/490 (47.96%), Postives = 314/490 (64.08%), Query Frame = 2

Query: 2054 EMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKE-----NSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVP-FRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            E+ + I +++++ ++++  F G+CVE  +  +V +YC KGSL+D+L+     LDWMF+ S   DIV GMI+LH S    HG+LK S C++DSR  +KLT FG+   R  +K      N  E+      K++ WT+PE+LR + LP  GT KGDV+SFAI+ +E   R    A        P +I++ V+    VP  RP L E   C   +  +I+Q WDE  + RPDF  +   +R         NILDN++S++E+YAN+LE +V  RT +   EKK+ + LL S+LP  V  QL   ++V  E YE VTI+F DIVGFT++SA STP++VI LLN LY   D II+ +DVYKVETIGDAYMV SGLP  NG  H  EIA M L FLS+I  F I H P  QL+LRIG++SGPV AGVVG+ MPRYCLFGDTVN +SRMES G PL IH+S +T  +LK    + + ERG + +KGKG QLTYWL G+
Sbjct:  142 EIPIGIYQMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINKQEDAWALSSKELYWTAPELLRMEDLPVNGTPKGDVFSFAILMRESTPREWPTATRANRVPFP-DIIDQVRDGIAVPPLRPLLTE--RCEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGLHMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 628

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086])

HSP 1 Score: 68.9366 bits (167), Expect = 3.806e-12
Identity = 46/167 (27.54%), Postives = 82/167 (49.10%), Query Frame = 2

Query: 2033 RKFETTKEMLLDIKKIKD------LNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAII 2515
            R+    KE+  D + +++      L + HICR   MC    H Y+++EY   G L D +  +  +L         + I   + YLH+N   H  LK  N ++ S   +K+ DFGL+ + + +K+       H +   + + +PE+L+ Q  P+ G  + D++SF I+
Sbjct:  156 RQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYII-QHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQ------LHTFCGSLYFAAPELLKAQ--PYTGP-EVDIWSFGIV 312

[Close]

BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529])

HSP 1 Score: 67.0106 bits (162), Expect = 1.392e-11
Identity = 46/168 (27.38%), Postives = 85/168 (50.60%), Query Frame = 2

Query: 2033 RKFETTKEMLLDIKKIKD------LNNDHICRFIGMCVEPLHQYLVYEYCPKGSLED-LLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAII 2515
            R+ +  KE+  D + I++      L + HICR   MC    H Y+++EY   G L D ++++  I      + +  + I   +IYLH+N   H  LK  N ++     +K+ DFGL+ + + +K+       H +   + + +PE+L+    P+ G  + DV+SF ++
Sbjct:  177 RQKKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFA--RGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQ------LHTFCGSLYFAAPELLKAN--PYTGP-EVDVWSFGVV 333

[Close]

BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931])

HSP 1 Score: 63.5438 bits (153), Expect = 1.107e-10
Identity = 45/178 (25.28%), Postives = 89/178 (50.00%), Query Frame = 2

Query: 2003 IVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLS-LIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLN-ILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEII 2530
            IVA+K +N     E  + +  +I  + +L +  I  +I   +E +  ++V EYC  GS  DLL+   +N     ++S +I ++  G+ YLH     H  +K++N +++   ++KL DFG++  +R   K ++       +     W +PE++  +   +    K D++S  I   E++
Sbjct:   43 IVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKRDT-------FVGTPYWMAPEVVCCEVDGY--NEKADIWSLGITTYELL 211

[Close]

BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 61.6178 bits (148), Expect = 5.521e-10
Identity = 41/161 (25.47%), Postives = 76/161 (47.20%), Query Frame = 2

Query: 2078 IKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVR----GMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVF 2548
            +K+L++++I  + G   E  +  +  EY P GS+  +L N        F  SLI +  R    G+ YLH     H  +K +N ++D +  +K+TDFG++  +++   N  +         + W SPE+++        T K D++S   +  E+   +  F
Sbjct:  508 LKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNY-----GPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGIS--KKLSPLNKKQNKRASLQGSVFWMSPEVVKQTAT----TAKADIWSTGCVVIEMFTGKHPF 657

[Close]

BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603])

HSP 1 Score: 58.151 bits (139), Expect = 7.129e-9
Identity = 39/124 (31.45%), Postives = 64/124 (51.61%), Query Frame = 2

Query: 1988 LFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGL 2359
            +F    VA   I + +   T K++L +I+  K +++ +I +FI    +  + Y++ E CP GSL +LL+  ++  +   R    Q I   + Y+HS    H  LK  N   DS + LK+ DFGL
Sbjct:  106 IFAAKTVAKASIKSEK---TRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQ-ICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGL 225

[Close]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO34275 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SPS9])

HSP 1 Score: 532.717 bits (1371), Expect = 1.442e-177
Identity = 272/522 (52.11%), Postives = 369/522 (70.69%), Query Frame = 2

Query: 1952 NIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSN-YGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEI--DGCS-SDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
            NI   Q+F    ++K N+VA+K+IN  R+ E T+E+  ++K ++ + ++++  F G CVEP +  ++ +YCPKGSL+D+LENE I LD MF  SL+ DIV+GM YLHS     HG LKS NCVVD R+VLK+TD+GLN  +  Q + S EE  +  Y + LWT+PE+LR       GT KGDVYSF II QE++ R G F +    + +P +I+E V   +  PFRP L  I  +G + + ++ + K  W+E+P++RPDF  I+ ++RK+  GK+S NI+DN+++ +E+YANNLE LV +RT +  +EK++ E+LL  MLP SVA  L+  + V+AE++++V+I+FSDIVGFTSLS++STP+QV++LLN LYT FD II N+DVYKVETIGDAYMVVSGLP  NG  HA EIA M L  L  I  F I HRPN +L+LRIG+HSG   AGVVG KMPRYCLFGDTVNT+SRMESNG  LKIHIS ST  +L     + + +RG+V +KGKG  +TYWL G +
Sbjct:    1 NINQRQIFTTVGIYKSNMVAIKRINK-RQIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPKGSLQDILENEDIKLDSMFVNSLLTDIVKGMAYLHSTEIRSHGRLKSPNCVVDGRWVLKITDYGLNKFKSNQ-DISEEEGEYAMYYRKLWTAPELLRAADPRPRGTQKGDVYSFGIIVQELLTRSGPFDLSYY-TNEPSDIIEKVTRVESPPFRPKLSTIVLEGPTVAGIVDLAKWCWEENPDHRPDFEEIRKTVRKLPMGKQS-NIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTENLLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVGSD 518

[Close]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO30985 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SZ80])

HSP 1 Score: 522.316 bits (1344), Expect = 5.129e-173
Identity = 260/500 (52.00%), Postives = 360/500 (72.00%), Query Frame = 2

Query: 2003 IVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKI-DKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAI-FRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWL 3493
            + AL K    R  + ++++LL++K+++D+ +D++ +FIG CV P +  +V +YC +GSL+D+LEN+ + LD +F  SL+ DIV+GM YLH S+   HG+LKSSNC+VDSR+VLK+TD+GL +LR   K+++ E      ++ +LW +PEILR  + P  GT KGDVYSF+II QE   R G ++    +  +PK I+E V+ S+  P+RP +  +   + +L  ++KQ W EDP+ RPDF  IK ++R+I DK     NI DN+++ ME YA+NLE LVAQRT + ++EK++ + LL S+LP+ VA QL K ++V AES+ +VTIYFSDIVGFTSLSA+STPMQV+  LN LYT FD II+ +DVYKVETIGDAYMV SGLP  NGR HA EIA+M L  + A+   F++ H+P  +L+LR+G H+GPV AGVVG+ M RYCLFGDTVNT+SRMESNG PL+IHIS  T +VL    TF++  RG+V +KGKG   T+WL
Sbjct:    5 VAALPK----RTIDISRQLLLEMKQMRDIRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDLVFIASLLSDIVKGMEYLHNSDIRSHGNLKSSNCLVDSRWVLKITDYGLPLLRSRSKKSTIET----NWRDLLWVAPEILRIPSRPPKGTHKGDVYSFSIILQEFHTRDGPYS---ANYMEPKAIIEKVRKSEFPPYRPIVANLIDGAEELRDLMKQCWAEDPDLRPDFTEIKKTVRRIVDKSGMKKNIFDNMVNMMEIYADNLENLVAQRTDQLVDEKRKTDALLESILPRPVAEQLKKGKAVEAESFNEVTIYFSDIVGFTSLSAESTPMQVVTFLNDLYTIFDDIIQEYDVYKVETIGDAYMVASGLPIRNGRRHAGEIAKMALHLVDAVSHNFIVRHKPEYKLQLRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWL 493

[Close]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36203 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA1])

HSP 1 Score: 416.001 bits (1068), Expect = 5.753e-133
Identity = 217/470 (46.17%), Postives = 306/470 (65.11%), Query Frame = 2

Query: 1973 FIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQ--TLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLD-EIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGL 3370
            F + +  K  +VALK +        T++ML+++K+++D+ + ++  +IG+C  P +  +V +YC +GSL+++L N++I+LDW FR S   DI  GM  +H S+   HG L+SS C++DSR+V K+ DFGLN+L+  Q+ +  E   H  Y ++ W +PE+L+ +  T   + T  GDVYSF II  E++ R   +A        P E++E ++   + PFRP    EI   S  + K++ Q W++DP  RP F  IK  +R +  GK S  I+DN+L  ME Y   LE +V +RT++  +EK + ++LLY MLP+ +A  L + + V AESY  VTI+FSDIVGFT L+A STP+QV++LLN LYT FD+II+  DVYKVETIGDAYMVVSGLP  NG  HA EIA M L  LS++  F   H PN  + LRIG+H+G   AGVVG KMPRYCLFGDTVN +SRMES G+
Sbjct:   59 FCEHSFIKSYLVALKMLRKD-SLTLTRDMLIEMKQVRDVQHTNLLHYIGVCTTPPNICIVSQYCHRGSLQEILANDEISLDWFFRESFANDIAMGMHVIHTSSIHVHGDLRSSKCLIDSRWVCKVADFGLNLLKANQRPDP-EIGVHAQYSRLFWRAPELLQNEKSTNKPVPTQMGDVYSFGIILNELLTREEPYATTEFA---PIEVIERIRCHLNPPFRPETPFEIRNRS--VTKLMTQCWNDDPQARPTFSDIKRQLRLLKGGKSS--IVDNMLRLMENYTEQLETIVDERTRQLADEKAKTDELLYKMLPRYIAESLKRGEPVIAESYSSVTIFFSDIVGFTELAAASTPLQVVDLLNDLYTCFDTIIDKHDVYKVETIGDAYMVVSGLPVRNGHRHAGEIATMALNLLSSMGNFRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGDTVNYASRMESTGV 519

[Close]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36182 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA4])

HSP 1 Score: 409.453 bits (1051), Expect = 6.447e-131
Identity = 225/501 (44.91%), Postives = 312/501 (62.28%), Query Frame = 2

Query: 2069 IKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVK--------GDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEI--DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRK--IDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPE 3532
            +K ++DL++ ++ R++G+CVE  +  +V  +C +G+L+DLL N+ I LDWMFR S   DI  GM  +H S    HG+LKSSNC++DSR+  K+TD+GL++LR  Q      E     YK + WT+PE+L     P     K        GDVYS+ I+  EII R   ++  N D+   K+++E V+  +   FRP   +   +     ++++ +  WD D   RP F  IK  ++   +  GK SG     + SR   Y NN   LV  R    +  K+    LL  +L + +A +L K  SVSAES++ VTI+FSDIVGFTS++A STP+QV++LLN+LYT FD +++  DVYKVETIGDAYMVVSGLP  NG  HA E+A M L  LS +  F IPH P+ +++LRIG+HSG   AGVVG KMPRYCLFGDTVN +SRMES+GL L+IH+S    EVL     + + ERG V MKGKG  +TY+L G++ F   P+P+
Sbjct:    1 MKMVRDLHHANLNRYLGVCVESPNICMVSRFCNRGTLQDLLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPKDIGE--FAVYKNLFWTAPELL-----PLADGFKDRKNKTQAGDVYSYGIVLYEIITRDEPYST-NTDTLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKLKANGMGNGKISG-----MFSR---YYNNFSKLVISRMGVCMALKR----LL--VLSRPIADELKKGNSVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMKGKGTIVTYFLTGKDGFD-KPLPD 478

[Close]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36204 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA3])

HSP 1 Score: 409.068 bits (1050), Expect = 8.543e-131
Identity = 227/490 (46.33%), Postives = 305/490 (62.24%), Query Frame = 2

Query: 2078 IKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLE-----------LRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDF 3511
            +  L++ +I  +IG+C+   +  +V E C +GSL D+L N+ I LDW F++S   DI  GM  LH S    HG+L SSNC+VD  +V K+ D+GL   R  +     EE       K LW +PE +R  +    G+  GDVYSF +I  EI+ R   F      +     I+  + S++  P RP+L+  D C   + K IKQ W E+P+ RP F  IK SMRKI+ G+ S  ++D++L +M+ Y+NNLE LV +RT++   EK + + LLY MLP+ VA QL   +SV AE ++QVT++FSDIVGFT LS+ STP+QV+  LN LYT FD+II N+DVYKVETIGDAYMVVSGLP  N   HA EIA M L  L  I  F I H P+T+L            L   + SGP  AGVVG K PRY +FGDTVN +SRMESNG+P +IHIS    + L +   + M  RGE+E+KGKGK +TY+L+G++ F
Sbjct:    2 VHKLSHVNINPYIGVCITAPNICIVSEACGRGSLADVLINDDIKLDWTFKMSFATDIAAGMEALHASEVSFHGNLTSSNCLVDRMWVCKIADYGLQ--RFSKHTYEPEEQLTGQTGKSLWMAPEHMRNAS--STGSQPGDVYSFGVILSEIVTRCEPFETLRATT----SILRRIMSTEFPPLRPTLNA-DDCDPTITKFIKQCWSEEPSARPTFRDIKKSMRKINGGR-SLRLVDSMLGKMDIYSNNLEVLVEERTRQLEAEKAKTDQLLYEMLPRPVADQLKSGKSVEAELFDQVTVFFSDIVGFTKLSSSSTPIQVVTFLNDLYTYFDNIIPNYDVYKVETIGDAYMVVSGLPEKNRDRHAGEIATMALHLLCDIRTFKIRHVPDTRLVSSYSLLLIITCLFYLIFSGPAVAGVVGIKKPRYDVFGDTVNVASRMESNGVPNRIHISAECRKALLNLGGYHMERRGEIELKGKGKVITYFLNGKDGF 481

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183])

HSP 1 Score: 615.535 bits (1586), Expect = 0.000e+0
Identity = 316/537 (58.85%), Postives = 394/537 (73.37%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            S    SY SL+T  G         Q+F KT  FKGN+VA+K +N  ++ E T+++L+++K ++D+  +H+ RFIG C++P +  +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH++Y GCHG+LKSSNCVVDSRFVLK+TD+GL   R     +   + SH  Y K LWT+PE+L     P  GT KGDVYSF II QEI  R G F V++ D   PKEIV+ V++ +   FRP+ D     S +L  +++  W EDP  RPDF  IK  M K++K + S +IL+NLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HAREIA M L  L  +  F I HRPN QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S +T EVL  F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  475 SQRGSSYGSLITAQG-------KYQLFAKTGYFKGNLVAIKHVNK-KRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCENDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMD-LSPKEIVQKVRNGQRPYFRPTTDS-RFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNK-EGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGE 996

HSP 2 Score: 97.8265 bits (242), Expect = 3.770e-20
Identity = 77/277 (27.80%), Postives = 128/277 (46.21%), Query Frame = 2

Query:  923 LSEFVFIHI--DLFTGLNPRPWFDQKSSDE----VNESVRNAFR-----SMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
            LSE +F+++  ++   ++ RP+ +++   E    + E+ R+ F      S+ ++    P N EY        L   A+  +  +     ++Y+  SFY+  +LYA+AL++  A+    +    IT    NR+F G    V ID    R  D  L+ + + ++G +  V +YNGST+     + + I W      PPLD P C F  D   C       G++   +  AL + G I  F  YR+LK + EL  M W + WE L      K+ +   SR
Sbjct:  200 LSEGIFMNLKDEMNMTVSARPYTNEQDYKELVSFIKENGRSKFTHQYDTSVFVITYHPPDNPEY--KDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHW--PSCGPPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFG-ISSFLIYRKLKLEKELAGMLWRVQWEDLQFESPNKYHKRAGSR 471

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183])

HSP 1 Score: 615.15 bits (1585), Expect = 0.000e+0
Identity = 316/537 (58.85%), Postives = 394/537 (73.37%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
            S    SY SL+T  G         Q+F KT  FKGN+VA+K +N  ++ E T+++L+++K ++D+  +H+ RFIG C++P +  +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH++Y GCHG+LKSSNCVVDSRFVLK+TD+GL   R     +   + SH  Y K LWT+PE+L     P  GT KGDVYSF II QEI  R G F V++ D   PKEIV+ V++ +   FRP+ D     S +L  +++  W EDP  RPDF  IK  M K++K + S +IL+NLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ HAREIA M L  L  +  F I HRPN QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG  LKIH+S +T EVL  F  F +  RG+VEMKGKGK  TYWL GE
Sbjct:  527 SQRGSSYGSLITAQG-------KYQLFAKTGYFKGNLVAIKHVNK-KRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCENDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMD-LSPKEIVQKVRNGQRPYFRPTTDS-RFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNK-EGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGE 1048

HSP 2 Score: 128.642 bits (322), Expect = 1.224e-29
Identity = 109/426 (25.59%), Postives = 188/426 (44.13%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADA-SSLKEIREKLKLLSSMSRVIIICGA-SKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
             F GP  +  L ++ R   + +   L++ G   Y FE  D  +Y+ + RI  +   L  F+  L   + W  R    + +FY   +    +++ ++ +   LK+       A   ++ ++ +E +  +    R+I ICG    +  ++ L   EI+ D   +   ++D+F     + +PW + K  D  N      F+S+ ++    P N EY        L   A+  +  +     ++Y+  SFY+  +LYA+AL++  A+    +    IT    NR+F G    V ID    R  D  L+ + + ++G +  V +YNGST+     + + I W      PPLD P C F  D   C       G++   +  AL + G I  F  YR+LK + EL  M W + WE L      K+ +   SR
Sbjct:  113 VFFGPGCVYPLASVGRFV-SHWKLPLITAGGPAYGFEKLD--EYKTIVRIGPSTTKLGAFVNVLHTQFNWTSRA---VVIFYDLKQDDRPHYFLSEGIFMNLKDEMNMTVSARPYTNEQDYKELVSFIKENGRIIYICGPLETFLSIMKLFQSEIQ-DPESYAIFYLDVFAESLTHRKPWQNAKF-DWTNPI--QVFKSVFVITYHPPDNPEY--KDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHW--PSCGPPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFG-ISSFLIYRKLKLEKELAGMLWRVQWEDLQFESPNKYHKRAGSR 523

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819])

HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0
Identity = 309/539 (57.33%), Postives = 394/539 (73.10%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
            S    +Y SL+T+ G       N Q++ KT  +KGN+VA+K IN  ++ E T+ +L ++K ++D++N+H+ RFIG CV+P +  ++ EYCP+GSL+DL+E+E + LDWMFR SLI DIV+GM +LH S    HG+LKSSNCVVDSRFVLK+TD+GL  LR     +S  + +H YY + LWT+PE+LRT+  P  GT KGDVYSF II QE+   +GVF +D   +  PKEI++ V        RPSL      S +L  ++++ W E+P  RPDF  IK  +RK  +G  S NILDNLLSRMEQYANNLE LV +RTQ Y EEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H RE+ARM L  L A+  F I HRP+ QL LRIGVHSGPVCAGVVG KMPRYCLFGDTVNT+SRMES G  LKIH+S +T +VL+ F TF +  RGE+E+KGKG   TYWL GE++
Sbjct:  529 SMKGSNYGSLMTMEG-------NLQIYTKTGYYKGNLVAIKYINK-KRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRT----SSCPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDT-HTLIPKEIIQGVIRGGVPLLRPSLC-FHSHSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDN 1052

HSP 2 Score: 154.451 bits (389), Expect = 1.469e-37
Identity = 125/444 (28.15%), Postives = 205/444 (46.17%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSD---YFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT----GLNP-RPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---------DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPW-----ESLDTVEKRKHRQSQISRKDS 1705
            AFIGP    S   +AR + T ++  +V+ G     F      ++  +T     H+ L  F  K+ + + W    H +  + + D+K  +D    +++ + +   +  +    +     S    +E ++++    RV+ +C +    R +M+   +  +DL  +VF  IDLF     G  P  PWF     D+ + + R AFRS+ ++    P N+EY        L+K A + +NF+      N +   FY+ +MLY+ ALN+  +K             D +T  MWNRTF G M  V++D  G+R  DF+L+D+ D  SG F+ V  YN S +   L +G + +W      PPL+ P+C F  D   C     +   +       +FVI +    F YR+LK + EL A  W + W      +LD V +R   +  IS K S
Sbjct:  107 AFIGPGCDYSSSPVARFT-THWDVPMVTAGARADGFS-----KFAAVTNTGPTHKKLGEFSLKIQETFGW----HHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDYFVESNINHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWF---RGDQDDHAARLAFRSVKVLTYMEPQNAEY--HQFVETLKKDAEKMFNFTIKDSLYNLIAGGFYDGVMLYSRALNETLSKRKPGLRPVQRPKGDMVTQRMWNRTFQGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVVCVYNSSIKELVLQKGLNFQWPG--GSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQMSNLDKVLRRACSRLTISMKGS 533

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819])

HSP 1 Score: 609.372 bits (1570), Expect = 0.000e+0
Identity = 309/539 (57.33%), Postives = 394/539 (73.10%), Query Frame = 2

Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
            S    +Y SL+T+ G       N Q++ KT  +KGN+VA+K IN  ++ E T+ +L ++K ++D++N+H+ RFIG CV+P +  ++ EYCP+GSL+DL+E+E + LDWMFR SLI DIV+GM +LH S    HG+LKSSNCVVDSRFVLK+TD+GL  LR     +S  + +H YY + LWT+PE+LRT+  P  GT KGDVYSF II QE+   +GVF +D   +  PKEI++ V        RPSL      S +L  ++++ W E+P  RPDF  IK  +RK  +G  S NILDNLLSRMEQYANNLE LV +RTQ Y EEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP  NG+ H RE+ARM L  L A+  F I HRP+ QL LRIGVHSGPVCAGVVG KMPRYCLFGDTVNT+SRMES G  LKIH+S +T +VL+ F TF +  RGE+E+KGKG   TYWL GE++
Sbjct:  470 SMKGSNYGSLMTMEG-------NLQIYTKTGYYKGNLVAIKYINK-KRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRT----SSCPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDT-HTLIPKEIIQGVIRGGVPLLRPSLC-FHSHSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDN 993

HSP 2 Score: 87.4261 bits (215), Expect = 6.329e-17
Identity = 107/433 (24.71%), Postives = 175/433 (40.42%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSD---YFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT----GLNP-RPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPW-----ESLDTVEKRKHRQSQISRKDS 1705
            AFIGP    S   +AR + T ++  +V+ G     F      ++  +T     H+ L  F  K+ + + W    H +  + + D+K  +D    +++ + +   +  +    +     S    +E ++++    RV+ +C +    R +M+   +  +DL  +VF  IDLF     G  P  PWF     D+ + + R AFR    V+ P        SI N         YN S         TT   +S M               +   +  +W     G M  V++D  G+R  DF+L+D+ D  SG F          E   L +G + +W      PPL+ P+C F  D   C     +   +       +FVI +    F YR+LK + EL A  W + W      +LD V +R   +  IS K S
Sbjct:  107 AFIGPGCDYSSSPVARFT-THWDVPMVTAGARADGFS-----KFAAVTNTGPTHKKLGEFSLKIQETFGW----HHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDYFVESNINHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWF---RGDQDDHAARLAFR----VRHP--------SIFNSF-----SVYNLS---------TTITPQSFM--------------QIKMCSEPVWCVVSAGVMGTVEMDKFGDREIDFALWDMTDINSGKF----------EVKHLPKGLNFQWPG--GSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQMSNLDKVLRRACSRLTISMKGS 474

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc2 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125799])

HSP 1 Score: 602.053 bits (1551), Expect = 0.000e+0
Identity = 306/541 (56.56%), Postives = 395/541 (73.01%), Query Frame = 2

Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
            RGS    +Y SL+T +G       N QVF KT  +KGNIVA+K  N  ++ E  +++L ++K ++D+ N+H+ RFIG CV+P +  ++ EYCP+GSL+D+LEN+ I L+WMF+ SLI DIV+GM++LH S    HG LKSSNCVVD+RFVLK+TD+GL+  R+     S+   SH YY + LW +PE+LR +  P  GT KGDVYSF+II QE+  RRG F +D  D   PKEIV+ V        RPS+D     S +L +++++ W E+P  RPDF  I+  +RK +K   + NILDNLLSRMEQYANNLE LV +RTQ Y EEK++AE LLY +LP SVA QL + ++V AE+++ V+IYFSDIVGFT+LSA+STPM+V+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP  NG+ H REIARM L  L  +  F I HRP  QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMES+G  LKIH+S +T +VL  F +F +  RG++++KGKGK  TYWL GE+D
Sbjct:  539 RGS----NYGSLMTANG-------NLQVFAKTGYYKGNIVAIKYTNK-KRIELNRKVLFELKHMRDVQNEHLTRFIGACVDPPNICIITEYCPRGSLQDILENDSITLEWMFKFSLINDIVKGMVFLHNSVIFSHGKLKSSNCVVDNRFVLKITDYGLSTFRQESDVGSD---SHSYYAQKLWMAPELLRMENPPPQGTQKGDVYSFSIILQEVALRRGAFYLDG-DPLSPKEIVDRVILGDWPCLRPSIDP-QSHSPELGQLMQRCWAEEPTERPDFNHIRLLLRKHNKESRT-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVSIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMALALLDTVRTFRIRHRPEQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGESD 1061

HSP 2 Score: 145.591 bits (366), Expect = 8.649e-35
Identity = 113/414 (27.29%), Postives = 191/414 (46.14%), Query Frame = 2

Query:  455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKE-MMERLKNYKTEGYKADASSLKE---IREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALND---LYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEW-GNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
            AFIGP    +   +   + T ++  L++ G       F D + Y  +T     H+ L  F  ++ + + W     + + + + D+K      Y A E + E LK+       +     K      + L  + ++ RV+ +C +    R +M+   +  L   ++VF++IDLF  +  N +PW      D +    ++AF+S+ I+  + P N EY       DL+  A+  +N+S     +N +   FY+ +MLYA ALN+   +         I+  MWNRTF+G    + +D  G+R +DF+L+DL D  S +FQ V  YN   E  + + G S+ W G  +   PLD PKC F  D   C     +   +   T   +F + +    F  R++K + EL A  W I W+ +
Sbjct:  122 AFIGPGCSYTASPVGLFT-THWDVPLITAGAPA--IAFLDGI-YPTITNTGPTHKKLGRFALRICEHFGW----REYVTLMFSDNKEDDRPCYFAMEGLYEELKSINISLQDSVFEENKPPINYSQILADIQNIGRVMFVCCSPDVFRRLMIEFWKADLPHEQYVFLYIDLFAVSLSNKQPWARGDQDDTI---AKDAFQSVKILSYREPQNQEY--QQFVRDLKADAKTSFNYSVQDSLMNIIAGGFYDGLMLYAHALNETALVPGARPPGKLISGKMWNRTFHGVTGLLHLDVSGDRETDFALWDLVDTNSSSFQIVVVYNSFEEQVTPVPGTSVRWLGGAR---PLDVPKCGFKNDNPACLTKTITIHQMVSITLFFIFTMTLTIAIFICRKMKLEKELVAQLWRISWDDI 519

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BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000019264.1 (SMESG000019264.1)

HSP 1 Score: 2360.1 bits (6115), Expect = 0.000e+0
Identity = 1167/1170 (99.74%), Postives = 1168/1170 (99.83%), Query Frame = 2

Query:   47 MCTRNHFGGWLIFILLIXXXXXXXXXXXXXITLLAGMGSYKCGKKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKIIQCE 3556
            MCTRNHFGGWLIFILLISESNSSDNNDGNGITLLAGMGSYKCGKKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIE +KKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFD KSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGDKKLDKKDQKKKKSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKIIQCE
Sbjct:    1 MCTRNHFGGWLIFILLISESNSSDNNDGNGITLLAGMGSYKCGKKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIENMKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDPKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGDKKLDKKDQKKKKSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKIIQCE 1170

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000056411.1 (SMESG000056411.1)

HSP 1 Score: 989.949 bits (2558), Expect = 0.000e+0
Identity = 529/1094 (48.35%), Postives = 710/1094 (64.90%), Query Frame = 2

Query:  311 IEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNH-ESLTNFM-GKLLKFYKWLPRPHKNIGVFYID--DKSYSDY-----FYSAKEMMERLKNYK----TEGYKADASSLKEIREKL-KLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLN--PRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVP 3529
            +EK++K   +         L+  +S  +  H+ + +    F+ + P   F GP     +  IAR+    +NR +++ G   Y F      ++  LTR+   H +  T ++  +L   YKW    +K   +F+ D  + +   Y      Y  K   + +KN+     TE +  D  +   I   L + + + + + I+C      R IML A  +     E++F++ID+F+  +   RPW+ +   +E NE  + AFR+++ + L  P   +Y       ++++ A+ +YNF+   E +N   +SF+++++LYAL LND  +K   ++    +   MWNR+F    T V I  +G+R +DFSL DL+ ++G F+ V  Y G    Y  +  K I+WG   N+ PLDTP C +D S C K G + G I      A   I +IGG F +RR KFQAEL AMNWIIPW+ L+T EKR+ + S          +   N       + +    + + +   E IE    +     +           R   ++   SN S  SL TI G+ L+++   Q+F KTALFKGN+VALK IN   K E T E+L++IKKIKD++NDHICRFIG+C++  H Y+VYEYCPKGSLED+L  EQI LDWMF+ SL+QDI RGMIYLH+N+G HG+LKSSNC+VDSRFVLK+TDFGL  L+  +    +EEP+  YYK  LWT+PE+L     P  GT+KGDVYSFA+I QEI+YR GVF++    +   KEI E V++    PFRP+L   DGC+ D++K+I+QAWDEDP +RPDF  IK  MRK++KG ++GNILDNLLSRMEQYANNLEGLVA+RT++YLEEK++AEDLLYSMLPK VAHQLIKNQ+V AESY+ VTI+FSDIVGFT+LSA+STPMQ+IELLNRLYTTFDSIIEN+DVYKVETIGDAYMV SGLP +NG  H+REIARM + FL AI  F+IPHRP+ +LELRIG+HSGPVC+GVVG KMPRYCLFGDTVNTSSRMESNGLPLKIHIS ST E+L +F TFI+SERG +++KGKG QLTYWLHGE+  IVDP+P
Sbjct:   73 LEKVRKMENINPIIKNIKILYPIDSDCLQTHKPLYESVINFVKEMPDVIF-GPICDYVIAPIARLMAF-WNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKW----NKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKY--KEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSN--IMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSKKKKHKLNKLRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGKIEITTELLIEIKKIKDMSNDHICRFIGVCLD--HPYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNM-YYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLP 1153

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1)

HSP 1 Score: 984.941 bits (2545), Expect = 0.000e+0
Identity = 525/1069 (49.11%), Postives = 702/1069 (65.67%), Query Frame = 2

Query:  431 FILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLT--NFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYF---------YSAKEMMERLKNYKTEGYK--ADASSLKEIREKLKLLSSMSR---VIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPR--PWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKK--DGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKH--RQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNE-----SYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV-PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESA 3538
            F+   P     GP     L  IAR+    +N  ++S G   Y F  + K +++ LTRI   H  L     + K  K YKW        G++     +Y++           Y  +E    +  +    YK    A+   +   +  L+ ++     V ++C        I+L A ++  +  E+VFI+I LF+  N    PW+   S+   N   + A+RS+L V  K+P N ++ N S  + ++++A  +YN+ Y K+ +N   ++FY+ ++LYA ALN   A    +     I   MWN TF G    V ID+ G+R++DFS+ D+DPK+G F+ V  + G+  ++ ++   S++WG+  N  P   P+C +D S+C K     + G I       LF+I    G+F YR +K QAEL AMNWIIPWESL+T EK ++    + +  +   ++ + +            + +S N +G++   EME   LL+     S     ++  N K+ G+   +     S  SL TI+G+ L+ IQN Q+F KTAL+KGN+VALK I + R+ +  +++L+ +KK+KDLNNDHICRFIG C+E  +QY+VY+YCPKGSLED+L  EQI LDW+F+ SLIQDI RGM+YLH+N G  G LKSSNC+VDSRFVLK+TDFGL  LR   K+   EE S+ Y+K +LWT+PE+LR    P  GT KGDVYSFAI+ QEI+YR+GVF++D+ D    +EIVESVK+     PFRPSL  I GC+ D + +IKQ+W+EDP  RPDF  IK  MRK +K  +SGNILDNLLSRMEQYANNLE +V +RT++YLEEKK+AEDLLYSMLPKSVAHQLIKNQ V+AESY+ VTI+FSDIVGFT+LSA+STPMQ+I+LLNRLYTTFDSIIEN+DVYKVETIGDAYMV SGLP +NG  HAREIARM + FLSAIF FVIPHRP+ +L+LRIG+HSGPVC+GVVG KMPRYCLFGDTVNTSSRMESNGLP KIHIS STM++LK+F TF+M+ERG +E+KGKG   TYWLHGEN+ IVDPVP+ A
Sbjct:  101 FVTQMP-DVLFGPICGYVLAPIARLLAF-WNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKW------THGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFS--DQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVK---------VHQSRSQNVKGTRN--EMENLHLLHEVEKPSS---KISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRG-SKQYLLEEDSNVYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPKDA 1144

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1)

HSP 1 Score: 979.163 bits (2530), Expect = 0.000e+0
Identity = 524/1067 (49.11%), Postives = 694/1067 (65.04%), Query Frame = 2

Query:  431 FILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLT--NFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYF---------YSAKEMMERLKNYKTEGYK--ADASSLKEIREKLKLLSSMSR---VIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPR--PWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKK--DGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNE-----SYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV-PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESA 3538
            F+   P     GP     L  IAR+    +N  ++S G   Y F  + K +++ LTRI   H  L     + K  K YKW        G++     +Y++           Y  +E    +  +    YK    A+   +   +  L+ ++     V ++C        I+L A ++  +  E+VFI+I LF+  N    PW+   S+   N   + A+RS+L V  K+P N ++ N S  + ++++A  +YN+ Y K+ +N   ++FY+ ++LYA ALN   A    +     I   MWN TF G    V ID+ G+R++DFS+ D+DPK+G F+ V  + G+  ++ ++   S++WG+  N  P   P+C +D S+C K     + G I       LF+I    G+F YR +K QAEL AMNWIIPWESL+T EK ++               L+N +    +             S+ +  ME   LL+     S     ++  N K+ G+   +     S  SL TI+G+ L+ IQN Q+F KTAL+KGN+VALK I + R+ +  +++L+ +KK+KDLNNDHICRFIG C+E  +QY+VY+YCPKGSLED+L  EQI LDW+F+ SLIQDI RGM+YLH+N G  G LKSSNC+VDSRFVLK+TDFGL  LR   K+   EE S+ Y+K +LWT+PE+LR    P  GT KGDVYSFAI+ QEI+YR+GVF++D+ D    +EIVESVK+     PFRPSL  I GC+ D + +IKQ+W+EDP  RPDF  IK  MRK +K  +SGNILDNLLSRMEQYANNLE +V +RT++YLEEKK+AEDLLYSMLPKSVAHQLIKNQ V+AESY+ VTI+FSDIVGFT+LSA+STPMQ+I+LLNRLYTTFDSIIEN+DVYKVETIGDAYMV SGLP +NG  HAREIARM + FLSAIF FVIPHRP+ +L+LRIG+HSGPVC+GVVG KMPRYCLFGDTVNTSSRMESNGLP KIHIS STM++LK+F TF+M+ERG +E+KGKG   TYWLHGEN+ IVDPVP+ A
Sbjct:  101 FVTQMP-DVLFGPICGYVLAPIARLLAF-WNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKW------THGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFS--DQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRN---------------LVNHNCVKYQSKPIHNSKVKVHQSRSQ-NMENLHLLHEVEKPSS---KISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRG-SKQYLLEEDSNVYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPKDA 1137

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000068881.1 (SMESG000068881.1)

HSP 1 Score: 949.888 bits (2454), Expect = 0.000e+0
Identity = 513/1049 (48.90%), Postives = 697/1049 (66.44%), Query Frame = 2

Query:  452 HAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTR----IAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKA----DASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGL--NPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKE---KIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQT-LPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAK 3541
            + + GP    SL  IAR+        +   G +G   + K + +Y  LTR    I  +H  L     K+ + Y W       + + Y  ++++ ++  S   + +  +NYK + +K+    +A +L EI      + S + V+++C   +  R I+L A ++     E+VFI+IDL T    N +PW+ +  +DEVN   + A+RS+L V  + P + EY N     +++    EKY      EE N     F++S++LYALALND  A N T +    IT  MWNRT  G    + ID  G+R +D+S+ D+D  +G F+ V  Y G  + Y  +EG+ I+W N+KN PP   P C ++   C       G I   T AA+ +  +I GF+ Y+R+KFQAEL AMNW+IPW++++T EKR HR +        V++TL N +            +  +Q SK    K + E+ +L+ +P+   D+     +++   R ++ N S  S  + +G+Q +N+   + FI TAL+KGN+VALK+++  +K E  + +L+++KK+K+LNN+HICRFIG+C++    +L+ EYCPKGSL+D+LENEQINLDWMF+ SL+QDI RGMIYLHSN G HG+LKSSNC+VDSRFVLK+ DFGL  LR   KE   E   + YY+ +LWT+PEILR  T +    + K DVYSF II QE++YR GVF + + +  +PK+IVE V   + +P+RP L E + CS  L +II+Q+W ED + RPDF  IK  MR ++KG +SGNILDNLLSRMEQYANNLE LV QRT++YLEEK++ EDLLYSMLPKSVA QLI+N++V+AESYE V+IYFSDIVGFT+LSA+STPMQVIELLNRLYTTFDSIIE+FDVYKVETIGDAYMV SGLP  NG  H REIARM L FLSAIF F IPH+PN ++ELRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIH+S  +++VL++FQ FI+S+RG+V MKGKG Q TYWLHGE+  IVDP+PES +
Sbjct:   52 YVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHE-EYSTLTRVNSIIVTDH--LKVLFRKIFQMYNW-----SRVKLIY--EQTFLNFCRSVGTLFDS-ENYKNKTFKSVVLLNAETLLEID-----MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQN--FIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKR-HRLTH------KVSDTLPNSELF----------TKRFQYSKRGLAKFDEESDVLIGNPSLAGDV-----VKSRPSRVNSINISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRG-TKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINL-EPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCE 1055

The following BLAST results are available for this feature:

BLAST of Guanylate cyclase vs. Ensembl Human
BLAST of Guanylate cyclase vs. Ensembl Celegans
BLAST of Guanylate cyclase vs. Ensembl Fly
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
BLAST of Guanylate cyclase vs. Ensembl Xenopus
BLAST of Guanylate cyclase vs. Ensembl Mouse
BLAST of Guanylate cyclase vs. UniProt/SwissProt
BLAST of Guanylate cyclase vs. TrEMBL
BLAST of Guanylate cyclase vs. Ensembl Cavefish
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
BLAST of Guanylate cyclase vs. Ensembl Yeast
BLAST of Guanylate cyclase vs. Ensembl Nematostella
BLAST of Guanylate cyclase vs. Ensembl Medaka
BLAST of Guanylate cyclase vs. Planmine SMEST

BLAST of Guanylate cyclase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NPR1	3.535e-45	56.19	natriuretic peptide receptor 1 [Source:HGNC Symbol...	[more]
NPR2	3.791e-35	56.55	natriuretic peptide receptor 2 [Source:HGNC Symbol...	[more]
GUCY2F	2.588e-133	45.77	guanylate cyclase 2F, retinal [Source:HGNC Symbol;...	[more]
GUCY2D	5.474e-130	44.44	guanylate cyclase 2D, retinal [Source:HGNC Symbol;...	[more]
GUCY2C	2.525e-125	43.80	guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of Guanylate cyclase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gcy-28	3.323e-39	55.21	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-28	6.956e-44	55.21	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-28	1.098e-46	55.21	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-28	0.000e+0	52.88	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-21	1.382e-138	37.82	Receptor-type guanylate cyclase gcy-21 [Source:Un...	[more]

BLAST of Guanylate cyclase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG3216	0.000e+0	36.23	gene:FBgn0034568 transcript:FBtr0273396	[more]
CG31183	2.931e-48	56.59	gene:FBgn0051183 transcript:FBtr0346151	[more]
CG31183	2.931e-48	56.59	gene:FBgn0051183 transcript:FBtr0083187	[more]
CG10738	4.212e-159	49.25	gene:FBgn0036368 transcript:FBtr0304791	[more]
CG10738	4.243e-159	49.25	gene:FBgn0036368 transcript:FBtr0304792	[more]

BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
npr1b	0.000e+0	45.14	natriuretic peptide receptor 1b [Source:ZFIN;Acc:Z...	[more]
npr1b	0.000e+0	40.08	natriuretic peptide receptor 1b [Source:ZFIN;Acc:Z...	[more]
si:dkey-37g12.1	0.000e+0	38.88	si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-1...	[more]
si:dkey-37g12.1	0.000e+0	38.63	si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-1...	[more]
npr2	4.708e-33	57.54	natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZD...	[more]

BLAST of Guanylate cyclase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NPR2	0.000e+0	57.79	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	0.000e+0	57.79	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	0.000e+0	57.79	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	0.000e+0	57.79	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	0.000e+0	57.79	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]

BLAST of Guanylate cyclase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Npr1	3.388e-41	57.36	natriuretic peptide receptor 1 [Source:MGI Symbol;...	[more]
Npr2	1.150e-36	56.62	natriuretic peptide receptor 2 [Source:MGI Symbol;...	[more]
Npr2	0.000e+0	56.62	natriuretic peptide receptor 2 [Source:MGI Symbol;...	[more]
Npr2	6.183e-157	54.64	natriuretic peptide receptor 2 [Source:MGI Symbol;...	[more]
Gucy2g	3.280e-137	44.64	guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:10...	[more]

BLAST of Guanylate cyclase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P18910\|ANPRA_RAT	8.511e-42	57.54	Atrial natriuretic peptide receptor 1 OS=Rattus no...	[more]
sp\|P18293\|ANPRA_MOUSE	2.370e-40	57.36	Atrial natriuretic peptide receptor 1 OS=Mus muscu...	[more]
sp\|P16066\|ANPRA_HUMAN	1.698e-44	56.19	Atrial natriuretic peptide receptor 1 OS=Homo sapi...	[more]
sp\|Q6VVW5\|ANPRB_MOUSE	8.042e-36	56.62	Atrial natriuretic peptide receptor 2 OS=Mus muscu...	[more]
sp\|P16067\|ANPRB_RAT	2.018e-35	56.73	Atrial natriuretic peptide receptor 2 OS=Rattus no...	[more]

BLAST of Guanylate cyclase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
G4V651	0.000e+0	48.05	Guanylate cyclase OS=Schistosoma mansoni OX=6183 G...	[more]
A0A1I8JDN4	0.000e+0	45.19	Guanylate cyclase OS=Macrostomum lignano OX=282301...	[more]
A0A1I8HCY1	0.000e+0	44.32	Guanylate cyclase OS=Macrostomum lignano OX=282301...	[more]
A0A1I8GAT2	0.000e+0	42.78	Guanylate cyclase OS=Macrostomum lignano OX=282301...	[more]
A0A267FJR9	0.000e+0	49.05	Guanylate cyclase OS=Macrostomum lignano OX=282301...	[more]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
npr1b	6.725e-34	58.70	atrial natriuretic peptide receptor 1-like [Source...	[more]
npr1b	6.725e-34	58.70	atrial natriuretic peptide receptor 1-like [Source...	[more]
npr1a	9.116e-22	55.56	natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z...	[more]
npr1b	8.557e-34	55.56	atrial natriuretic peptide receptor 1-like [Source...	[more]
npr1b	7.103e-34	55.56	atrial natriuretic peptide receptor 1-like [Source...	[more]

BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000006352.1	1.106e-36	58.46	pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 ...	[more]
NPR1	0.000e+0	56.16	natriuretic peptide receptor 1 [Source:HGNC Symbol...	[more]
ENSPMAT00000008976.1	1.161e-144	37.22	pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-...	[more]
ENSPMAT00000008942.1	4.558e-138	46.58	pep scaffold:Pmarinus_7.0:GL476454:59555:94399:-1 ...	[more]
ENSPMAT00000008986.1	2.496e-137	47.96	pep scaffold:Pmarinus_7.0:GL476454:105373:128493:-...	[more]

BLAST of Guanylate cyclase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
KIN2	3.806e-12	27.54	Serine/threonine protein kinase involved in regula...	[more]
KIN1	1.392e-11	27.38	Serine/threonine protein kinase involved in regula...	[more]
SPS1	1.107e-10	25.28	Putative protein serine/threonine kinase; localize...	[more]
STE11	5.521e-10	25.47	Signal transducing MEK kinase; involved in pheromo...	[more]
CDC5	7.129e-9	31.45	Polo-like kinase; controls targeting and activatio...	[more]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO34275	1.442e-177	52.11	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30985	5.129e-173	52.00	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36203	5.753e-133	46.17	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36182	6.447e-131	44.91	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36204	8.543e-131	46.33	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
npr2	3.770e-20	58.85	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
npr2	1.224e-29	58.85	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
olgc7	1.469e-37	57.33	membrane guanylyl cyclase [Source:NCBI gene;Acc:10...	[more]
olgc7	6.329e-17	57.33	membrane guanylyl cyclase [Source:NCBI gene;Acc:10...	[more]
olgc2	8.649e-35	56.56	membrane guanylyl cyclase [Source:NCBI gene;Acc:10...	[more]

BLAST of Guanylate cyclase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000019264.1	0.000e+0	99.74	SMESG000019264.1	[more]
SMESG000056411.1	0.000e+0	48.35	SMESG000056411.1	[more]
SMESG000010241.1	0.000e+0	49.11	SMESG000010241.1	[more]
SMESG000010241.1	0.000e+0	49.11	SMESG000010241.1	[more]
SMESG000068881.1	0.000e+0	48.90	SMESG000068881.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30008651 ID=SMED30008651|Name=Guanylate cyclase|organism=Schmidtea mediterranea sexual|type=transcript|length=3660bp
GTATTAATATGAAGTTTTAAAAAAAAACGAAGTTTCAAATCGATCAATGT
GTACAAGAAATCATTTCGGAGGCTGGTTAATTTTCATTTTATTAATTTCC
GAGTCGAATTCAAGTGACAATAATGATGGAAATGGAATAACTTTATTGGC
TGGAATGGGCAGTTATAAATGTGGGAAAAAATTGTCTCCTCGAGAATTTC
GAATTGCCGTTCTCATGACAAATTCGAATCTGGAAAAAAACAATGGAAAT
AATATGATTGTGGAAAATTCAAAAAAATTAGGACCAATAACTGATTTGGC
ATTAGCTAGAATTGAAAAATTGAAAAAGAAAGGAGAATTACAAGGTTTTG
CCAACTATTCCCTTAAATTATTCTTCAGTGAAAGCAGTACAGTGAGTGAA
CATCAAAATATAATGAAGAGATTTTTTTATTTCATTCTTGATGAACCGGT
TCATGCATTCATTGGTCCTAATAGTATTATTTCACTTGGAACTATCGCGC
GTATGTCCGGTACAAGATTCAATAGATCACTTGTAAGTCTTGGTGAAGCT
GGATATCAATTTGAGTTCAAAGATAAAGTTCAATATCAAGGACTTACAAG
AATTGCTGGGAACCATGAATCTTTGACCAATTTTATGGGTAAACTATTAA
AGTTCTATAAATGGCTACCAAGACCGCATAAAAATATTGGAGTTTTCTAC
ATAGATGATAAATCGTACAGTGATTATTTTTACTCGGCTAAAGAAATGAT
GGAAAGATTAAAAAATTATAAAACCGAAGGATATAAAGCTGATGCAAGTA
GTTTGAAAGAAATTAGAGAAAAATTAAAGTTACTATCTTCAATGTCCCGA
GTGATTATTATTTGCGGAGCAAGCAAATATACGAGATTGATAATGCTAGC
AGCGGTAGAAATCAAATTAGATTTATCAGAATTCGTTTTTATTCATATAG
ATCTGTTTACAGGACTTAATCCTCGTCCTTGGTTTGATCAGAAGAGTTCA
GATGAAGTCAACGAAAGTGTCCGTAACGCATTTAGGTCAATGCTAATTGT
CAAGCTTCCTTTAAATAGTGAATATTGGAACAGTTCAATTGGAAATGATT
TAAGAAAAATTGCTCGTGAAAAATATAATTTTTCTTATCCAAAAGAAGAG
CTGAATTACGTAACTACTTCGTTCTATGAATCCATTATGCTATATGCTCT
AGCACTAAATGATCTTTACGCCAAAAATGATACTCTGGATCGAATTACAA
ATTATATGTGGAATAGGACATTTAATGGCTTTATGACACCAGTAAAAATA
GATGCGGAAGGAAATCGAGTCTCGGATTTTTCATTATTTGACTTAGACCC
AAAATCTGGGAATTTTCAACAAGTTGGATTTTACAATGGCTCGACTGAAA
CCTACAGTCTCATTGAAGGGAAGTCCATTGAATGGGGAAACGAAAAAAAT
GAGCCCCCATTAGATACGCCAAAATGTGCATTTGATGGATCTCTTTGTAA
AAAAGATGGTACCAGTACTGGTCTTATTTTCGGATGTACGACGGCAGCCC
TGTTTGTGATCGGGGTGATCGGAGGATTTTTCGCTTACAGACGGCTGAAA
TTTCAAGCCGAACTCAAAGCCATGAACTGGATAATTCCTTGGGAATCGCT
TGATACGGTTGAAAAACGAAAGCATCGGCAATCTCAAATATCAAGGAAAG
ACTCAACTGTCAATGAAACACTAATAAATGGTGATAAGAAATTGGATAAG
AAAGATCAAAAGAAAAAGAAATCCGGAAATTATCAAGGTTCAAAAGAAAA
AATAGAGATGGAAACTACTCTATTGCTTAATTCACCGAATTCTGATTCTG
ATATTGATCCCATGGTAGCAATACGAAATGGAAAACATCGAGGAAGTGCT
TCAAATGAAAGTTATATGTCGTTGGTTACTATTTCCGGTGTTCAGTTAGA
AAACATTCAAAATACCCAAGTTTTCATCAAAACTGCATTGTTTAAAGGCA
ATATTGTGGCATTGAAAAAAATTAATACTGGTAGGAAATTTGAAACAACA
AAGGAAATGCTTTTAGATATTAAAAAGATAAAAGATTTAAACAATGATCA
TATTTGTCGGTTTATTGGAATGTGTGTTGAACCTCTTCACCAATATCTTG
TGTATGAATACTGTCCGAAAGGGAGCTTGGAAGATCTTTTAGAAAATGAA
CAGATAAATTTGGATTGGATGTTTCGTCTTTCACTGATTCAGGATATTGT
TCGGGGAATGATATATTTGCATTCAAATTATGGATGTCATGGTCACTTAA
AAAGTTCAAACTGTGTCGTTGACTCTAGATTTGTTTTAAAATTAACAGAC
TTTGGACTGAACATTTTACGAGAAATACAAAAAGAAAACTCTAACGAAGA
ACCTTCTCATGAATATTATAAAAAAATGTTATGGACAAGTCCAGAAATTT
TACGAACTCAAACTCTTCCTTTCATTGGCACTGTCAAAGGTGATGTTTAT
AGTTTTGCAATAATAGCTCAAGAAATAATTTATCGGCGCGGAGTATTTGC
GGTTGATAACTGTGATTCCAAAGATCCGAAAGAAATTGTCGAATCTGTAA
AGTCTTCTAAACATGTTCCTTTCCGACCAAGTTTGGATGAAATAGATGGT
TGCTCTTCAGATTTGATCAAGATAATTAAACAAGCCTGGGATGAAGATCC
AAATAATAGACCAGACTTTCCCGGGATTAAAAATTCAATGAGGAAAATAG
ACAAAGGAAAAGAATCAGGAAATATATTAGATAATTTACTTTCGCGTATG
GAACAATACGCAAACAATCTCGAAGGTTTAGTTGCTCAACGAACTCAGGA
ATATTTAGAAGAAAAGAAGAGAGCTGAAGACTTATTGTATTCAATGTTGC
CAAAATCAGTTGCTCACCAATTAATCAAAAATCAAAGCGTTTCGGCGGAA
AGTTACGAGCAGGTCACGATTTATTTCAGTGACATTGTCGGATTTACATC
TTTGTCAGCCGATTCGACACCTATGCAGGTTATTGAACTGCTAAATCGCC
TTTATACGACATTTGACAGTATAATTGAAAATTTCGATGTGTATAAGGTT
GAAACCATAGGAGATGCTTATATGGTTGTGTCAGGTCTTCCAAACGTGAA
CGGTAGGAATCATGCCCGGGAAATCGCTAGAATGTGTTTGCAGTTCCTGT
CGGCGATATTTCGTTTCGTGATTCCTCATCGGCCAAATACGCAGCTGGAG
TTGCGAATTGGAGTCCATTCAGGTCCAGTTTGTGCGGGTGTTGTCGGGCA
TAAAATGCCAAGATATTGCTTATTCGGAGATACAGTCAACACTTCCAGTA
GAATGGAGAGCAACGGTTTACCATTGAAAATCCACATCAGCCATTCCACA
ATGGAAGTGTTGAAGTCATTTCAGACCTTTATCATGAGTGAGCGTGGAGA
AGTCGAAATGAAAGGCAAAGGAAAGCAACTGACATATTGGCTTCATGGAG
AAAATGATTTCATAGTCGATCCAGTACCGGAAAGTGCCAAAATAATTCAA
TGTGAATAAAAAATGATAATTATAAAAATCGTACAATAAACTATATCAAG
ATTTCCACTGTGATATATTTTTTTAAGTTGCTTTATTTAAAACAAATGGT
TAGAATTCTA

protein sequence of SMED30008651-orf-1

>SMED30008651-orf-1 ID=SMED30008651-orf-1|Name=SMED30008651-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1171bp
MCTRNHFGGWLIFILLISESNSSDNNDGNGITLLAGMGSYKCGKKLSPRE
FRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQG
FANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTI
ARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKL
LKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADA
SSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIH
IDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGN
DLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDRI
TNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGST
ETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTA
ALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR
KDSTVNETLINGDKKLDKKDQKKKKSGNYQGSKEKIEMETTLLLNSPNSD
SDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFK
GNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQY
LVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGH
LKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPE
ILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVES
VKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRK
IDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSM
LPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLN
RLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQF
LSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTS
SRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLH
GENDFIVDPVPESAKIIQCE*

Aliases

The feature 'Guanylate cyclase' has the following synonyms


Synonym
gucy-2

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0016301	kinase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0016829	lyase activity

Vocabulary: **biological process**
Term	Definition
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction
GO:0009190	cyclic nucleotide biosynthetic process
GO:0006468	protein phosphorylation
GO:0006182	cGMP biosynthetic process

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000017	photoreceptor neuron
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0000420	parapharyngeal region

Vocabulary: **INTERPRO**
Term	Definition
IPR001170	ANPR/GUC
IPR001054	A/G_cyclase
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR001828	ANF_lig-bd_rcpt
IPR018297	A/G_cyclase_CS
IPR000719	Prot_kinase_dom
IPR029787	Nucleotide_cyclase
IPR028082	Peripla_BP_I
IPR011009	Kinase-like_dom_sf

Vocabulary: **cellular component**
Term	Definition
GO:0016021	integral component of membrane
GO:0005622	intracellular
GO:0016020	membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 911..931
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 640..937 e-value: 3.7E-58 score: 198.8
None	No IPR available	GENE3D	G3DSA:3.40.50.2300		coord: 76..428 e-value: 3.1E-77 score: 262.3
None	No IPR available	GENE3D	G3DSA:3.40.50.2300		coord: 192..479 e-value: 3.1E-77 score: 262.3
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 559..581
None	No IPR available	PANTHER	PTHR11920:SF470	GUANYLATE CYCLASE	coord: 136..581 coord: 622..1139
None	No IPR available	PANTHER	PTHR11920	ADENYLATE AND GUANYLATE CYCLASES	coord: 136..581
None	No IPR available	PANTHER	PTHR11920	ADENYLATE AND GUANYLATE CYCLASES	coord: 622..1139
None	No IPR available	CDD	cd07302	CHD	coord: 972..1139 e-value: 8.00019E-63 score: 209.358
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..22 score: 0.742
None	No IPR available	TMHMM	TMhelix		coord: 492..514
IPR001170	Adenylyl cyclase class-4/guanylyl cyclase	PRINTS	PR00255	NATPEPTIDER	coord: 376..394 score: 36.51 coord: 268..286 score: 43.75 coord: 494..516 score: 24.18
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	SMART	SM00044	cyc_6	coord: 938..1132 e-value: 1.7E-96 score: 336.5
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	PFAM	PF00211	Guanylate_cyc	coord: 966..1139 e-value: 4.0E-61 score: 205.8
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	PROSITE	PS50125	GUANYLATE_CYCLASE_2	coord: 974..1104 score: 49.395
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PFAM	PF07714	Pkinase_Tyr	coord: 652..896 e-value: 1.3E-37 score: 129.5
IPR029787	Nucleotide cyclase	GENE3D	G3DSA:3.30.70.1230		coord: 959..1139 e-value: 3.1E-74 score: 250.6
IPR029787	Nucleotide cyclase	SUPERFAMILY	SSF55073	Nucleotide cyclase	coord: 960..1139
IPR001828	Receptor, ligand binding region	PFAM	PF01094	ANF_receptor	coord: 123..436 e-value: 4.2E-24 score: 85.3
IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	PROSITE	PS00452	GUANYLATE_CYCLASE_1	coord: 1081..1104
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 609..901 score: 25.927
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 642..902
IPR028082	Periplasmic binding protein-like I	SUPERFAMILY	SSF53822	Periplasmic binding protein-like I	coord: 115..479