Guanylate cyclase
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30008651 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11
Homology
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943]) HSP 1 Score: 619.772 bits (1597), Expect = 0.000e+0 Identity = 313/557 (56.19%), Postives = 397/557 (71.27%), Query Frame = 2
Query: 1850 DIDPMVAIRNGKHRGS-----ASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGC-HGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
D++P R+ + GS +Y SL+T G QVF KTA +KGN+VA+K++N ++ E T+++L ++K ++D+ N+H+ RF+G C +P + ++ EYCP+GSL+D+LENE I LDWMFR SL DIV+GM++LH+ C HG+LKSSNCVVD RFVLK+TD+GL R++ E H Y K LWT+PE+LR + P G+ GDVYSF II QEI R GVF V+ D PKEI+E V + PFRPSL + +L ++++ W EDP RP F I+ ++RK ++ + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP NGR HA E+ARM L L A+ F I HRP QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S T VL+ F F + RG+VEMKGKGK TYWL GE
Sbjct: 514 DVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQG-----HTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLD-LSPKEIIERVTRGEQPPFRPSL-ALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNR-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054 HSP 2 Score: 179.874 bits (455), Expect = 3.535e-45 Identity = 122/429 (28.44%), Postives = 208/429 (48.48%), Query Frame = 2
Query: 458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLK---NYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT-----GLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDG--SLCKKDGTSTGLIFGCTTAALFVIGV-IGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
F+GP + + + R + + L++ G F KD +Y TR ++ L +F+ L + W R + + D+ + F+ + + R++ N + + L L+ + RVI IC + R +ML A+E L ++VF H+D+F G P P + D + S R AF++ I+ K P N EY L+ +A E++NF+ +N + SF++ ++LY A+ + A T+ + IT MWNR+F G +KID+ G+R +DFSL+D+DP++G F+ V YNG+++ + G+ + W PP D PKC FD C +D ST + +L ++G+ I FF YR+++ + EL + W + WE ++ +H +S SR
Sbjct: 113 FLGPGCVYAAAPVGRFT-AHWRVPLLTAGAPALGFGVKD--EYALTTRAGPSYAKLGDFVAALHRRLGW-ERQALMLYAYRPGDEEHC--FFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLE--FLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNW--PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLAL-VGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSR 530
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR2 (natriuretic peptide receptor 2 [Source:HGNC Symbol;Acc:HGNC:7944]) HSP 1 Score: 606.675 bits (1563), Expect = 0.000e+0 Identity = 311/550 (56.55%), Postives = 391/550 (71.09%), Query Frame = 2
Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
H+G+ S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RFIG C++P + +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++ HG LKSSNCVVDSRFVLK+TD+GL R S EP SH Y K LWT+PE+L LP G K DVYSF II QEI R G F ++ D PKEIV+ V++ + FRPS+D + +L+ ++++ W +DP RPDF IK +R+ +K E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HA EIARM L L A+ F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S +T + L F + RG+VEMKGKGK TYWL GE
Sbjct: 508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039 HSP 2 Score: 147.517 bits (371), Expect = 3.791e-35 Identity = 112/431 (25.99%), Postives = 194/431 (45.01%), Query Frame = 2
Query: 458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLKNYK-TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
+GP + ++AR + + + L++ G F K+ Y+ L R + L F+ L + W R + Y+D ++ ++++ + + E L+ + ++ A + + + R++ ICG + I+L A L ++VF ++D+F T RPW D ++ ++ +++R AF+++L++ + P N EY N L ARE + +N + FY+ I+LYA LN+ + T + RI M R ++G V +D +R +DF L+ + D SG+FQ Y+G+ E G+ I W K PP D P CAFD C K ST I T F++ + F +R+L + EL +M W I WE L ++ + SR
Sbjct: 96 LLGPGCVYPAASVARFA-SHWRLPLLTAGAVASGFSAKND-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSR 514
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2F (guanylate cyclase 2F, retinal [Source:HGNC Symbol;Acc:HGNC:4691]) HSP 1 Score: 436.802 bits (1122), Expect = 2.588e-133 Identity = 238/520 (45.77%), Postives = 340/520 (65.38%), Query Frame = 2
Query: 1985 ALFKGNIVALKKINTGR--KFETTKEMLLDI-KKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSF-QTFIMSERGEVEMKGKGKQLTYWLHGENDFIVD-PVP 3529
A+++G+ V LKK + G ++ K D+ + +KDL +++I +G + +V E+C +GSLED+L N+ + LDWMF+ SL+ D+++GM YLH HG LKS NCVVD RFVLK+TD+G N + E+ + + E +++LWT+PE+LR +G+ GDVYSFAII QE++ R F + + ++ EI+ +K K P + + + ++++KQ W E RP F I N + +KGK++ NI+D++L +EQY++NLE L+ +RT+E EK++ E LL MLP SVA L K +V E ++ VT+YFSDIVGFT++SA S P++V++LLN LYT FD+II + DVYKVETIGDAYMV SGLP NG HA EIA M L LS++ F + H P + +RIG+HSGPV AGVVG MPRYCLFGDTVNT+SRMES GLP +IH+S ST+ +L++ + + + RG E+KGKG + T+WL G+ F+ PVP
Sbjct: 564 AIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSM----EELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQ---EIINRLK--KPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKT-NIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVP 1073
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2D (guanylate cyclase 2D, retinal [Source:HGNC Symbol;Acc:HGNC:4689]) HSP 1 Score: 427.943 bits (1099), Expect = 5.474e-130 Identity = 236/531 (44.44%), Postives = 331/531 (62.34%), Query Frame = 2
Query: 1985 ALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVE-----PLHQY-----LVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSE-RGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKI 3544
+++G+ V LKK + K+++L ++++ ++G+ + P + +V E+C +GSL+DLL +I LDWMF+ SL+ D+++G+ YLH HG LKS NC+VD RFVLK+TD G L E QK E P E LWT+PE+LR L GT+ GDV+S AII QE++ R +A+ P+E+V+ V+S P L +D + I ++KQ W E P RP + + I+KG+++ NI+D++L +EQY++NLE L+ +RT+E EK++ + LL MLP SVA L V E +EQVT+YFSDIVGFT++SA S P++V++LLN LYT FD+II + DVYKVETIGDAYMV SGLP NG+ HA EIA M L LSA+ F + H P + +RIG+HSGP AGVVG MPRYCLFGDTVNT+SRMES GLP +IH++ ST+ +L++ + E RG E+KGKG + T+WL G F P+P+ +
Sbjct: 553 GVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLP-EPPRAE---DQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLELT---PEEVVQRVRSPP--PLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKT-NIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGF-NKPIPKPPDL 1072
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2C (guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:4688]) HSP 1 Score: 414.461 bits (1064), Expect = 2.525e-125 Identity = 233/532 (43.80%), Postives = 329/532 (61.84%), Query Frame = 2
Query: 2048 TKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQIN------LDWMFRLSLIQDIVRGMIYLHSNYG-CHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSL--DEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKI-----DKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQT-FIMSERGEVEMKGKGKQLTYWLHGEND----FIVDPVPESAKIIQCE*KMIIIKIVQ 3586
T++ +++ K+ ++ ++ +F G + V EYC +GSL ++L N+ I+ +DW F++S++ DI +GM YLHS+ HG LKS+NCVVDSR V+K+TDFG N + +K+ LWT+PE LR + + KGDVYS+ IIAQEII R+ F +C ++ K I S+ PFRP L + + ++ ++K W+EDP RPDF I+ ++ KI D+ ES +D L+ R++ Y+ NLE LV +RTQ Y E+ RA+ L + +LP+ V L + V E YE+VTIYFSDIVGFT++ STPM+V+++LN +Y +FD I+++ DVYKVETIGDAYMV SGLP NG HA +IA+M L+ LS + F + H P + +RIGVHSGP AGVVG KMPRYCLFGDTVNT+SRMES GLPL+IH+S ST+ +LK + F+ RGE +KG+G + TYWL G D P E+ + +Q E +I +Q
Sbjct: 526 TEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKD--------------LWTAPEHLRQANI----SQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEK-IFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNES--YMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQ 1035
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 603.594 bits (1555), Expect = 0.000e+0 Identity = 302/547 (55.21%), Postives = 391/547 (71.48%), Query Frame = 2
Query: 1916 MSLVTISGVQLENI--QNTQVFIKTALFKGNIVALKKINTGRK----FETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVK---SSKHVPFRPSLDEI------DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
+S + SG +E I NTQ++ KTA+FKG +VA+KK+N K + ++ L+++KK+KDL +DHI RF G C++ H +V EYCPKGSLED+LENE+I LD + + SL+ D+V+G+ +LH S HG LKSSNCVVDSRFVLK+TDFGL+ L +++ N E H YYKKMLWT+PE+LR P +GT KGD+YSFAII E+++R+GVFA++N D P EIV+ V+ S P RP + E D + L+ ++ W EDP+ RP+ ++ ++R +++ E+ N++DNLL RMEQYANNLEGLV +RTQEYL EKK+ E+LL+ +LP ++A LI ++V AESY+ VTIYFSDIVGFTSLS+ STPMQV+ LLN LY FD +++NF VYKVETIGDAYMVVSGLP +HA +IA+M L L + FVI HRP+ QL+LRIG+HSG V AGVVG KMPRYCLFGDTVNTSSRMESNGLPLKIH+S T ++L F + RG VEMKGKG Q TYWL G D
Sbjct: 721 VSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLS-PNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRD-DHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1265 HSP 2 Score: 159.844 bits (403), Expect = 3.323e-39 Identity = 149/524 (28.44%), Postives = 241/524 (45.99%), Query Frame = 2
Query: 272 KKLGPITDLALARIEKLKKKGELQGFAN--------YSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIG------VFYIDDK-------------------SYSDYF--YSAKE-MMERLKNYKTE--------GYKADASSLKE-IREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLS-EFVFIHIDLFTGLNP-RPWF-DQKSSDEVNESVRNAFRSMLIVKLPLNS--EYWNSSIGNDLRKIAREKYNFSY---PKEELNYVTTSFYESIMLYALALNDLYAKNDTLD-----RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKR 1669
+K P+ D+A+ + K KK G+ N Y L +TV +++ + LD A +G L T+ +++ N + L +G K +Y LTR+ G++ L + M +L+ ++ N +F+ DK S YF Y+ K E+ K +K E + D +E ++ L+ +S S VII+C + R IMLAA ++ + S E+VFI+ID+ TG + +PW +++E NE + A+R++ + L + EY N + +++ A +KYN++ E+N ++FY++++LYA+ALN+ LD IT+ MW RTF G V ID G+R SD+SL DLDP F +V +Y+G++ + + W K PP D P C +D S C L+ G L ++G+ F +RR K + EL AM+W I WE LD E +
Sbjct: 62 QKAMPVIDIAVQEVIKAKKLPP--GWINLTYWDSRLYEDILLAERHATVG----VIQAYCEHRLD----AILGFADNYGLATVTKVTAG-LNGGIPILTTSGMPSLLNSKKEYPFLTRMQGSYRLLADSMYQLIAYHDEDSVSKSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSSHCYFSLYAIKRYFTEKSKTFKREWALNTPQFPFDEDLVIERETFKQWLREISLQSNVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFEL--RVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSG--LDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGYDKSKCPGYPLHVYLLMGSFLLILVLVGLF--IFFWRRYKLEQELAAMSWKIRWEELDGEESQ 564
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 602.823 bits (1553), Expect = 0.000e+0 Identity = 302/547 (55.21%), Postives = 391/547 (71.48%), Query Frame = 2
Query: 1916 MSLVTISGVQLENI--QNTQVFIKTALFKGNIVALKKINTGRK----FETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVK---SSKHVPFRPSLDEI------DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
+S + SG +E I NTQ++ KTA+FKG +VA+KK+N K + ++ L+++KK+KDL +DHI RF G C++ H +V EYCPKGSLED+LENE+I LD + + SL+ D+V+G+ +LH S HG LKSSNCVVDSRFVLK+TDFGL+ L +++ N E H YYKKMLWT+PE+LR P +GT KGD+YSFAII E+++R+GVFA++N D P EIV+ V+ S P RP + E D + L+ ++ W EDP+ RP+ ++ ++R +++ E+ N++DNLL RMEQYANNLEGLV +RTQEYL EKK+ E+LL+ +LP ++A LI ++V AESY+ VTIYFSDIVGFTSLS+ STPMQV+ LLN LY FD +++NF VYKVETIGDAYMVVSGLP +HA +IA+M L L + FVI HRP+ QL+LRIG+HSG V AGVVG KMPRYCLFGDTVNTSSRMESNGLPLKIH+S T ++L F + RG VEMKGKG Q TYWL G D
Sbjct: 662 VSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLS-PNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRD-DHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1206 HSP 2 Score: 174.866 bits (442), Expect = 6.956e-44 Identity = 147/509 (28.88%), Postives = 248/509 (48.72%), Query Frame = 2
Query: 233 EKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKW----------LPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKA------DASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLS-EFVFIHIDLFTGLNP-RPWF-DQKSSDEVNESVRNAFRSMLIVKLPLNS--EYWNSSIGNDLRKIAREKYNFSY---PKEELNYVTTSFYESIMLYALALNDLYAKNDTLD-----RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKD-GTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKR 1669
E + G N + K P+ D+AL + L+ SLK+ F E+S +S+ K ++ ++ V A +G + +L +AR+S + + + E D+ ++ LTR+ G+++SL + ++ + ++W + R +N K S+ ++S + + N KT + +A L + R L S MS +II+C + R IMLAA ++ + S E+VFI+ID+ TG + +PW +++E NE + A+R++ + L + EY N + +++ A +KYN++ E+N ++FY++++LYA+ALN+ LD IT+ MW RTF G V ID G+R SD+SL DLDP F +V +Y+G++ + + W K PP D P C +D S C + L+ G L ++G+ F +RR K + EL AM+W I WE LD E +
Sbjct: 38 EGDRGKNPFLLTLAKSKPVFDVALQDVYHLRI------LPYGSLKVTF-ENSALSDAVGPQKMIEHYC-NKTVDAIMGLPYVYALAPVARISKF-WGQGVPVFTTTALVDELGDRNEFPLLTRMMGSYKSLGKLVTRIAERFEWQHYFFMFNDEVARGPRN--------KGRSECYFSLSAIKNLIMNNKTSTWNVKMFSEFEADRL-QYRALLSEASVMSNLIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFEL--RVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSG--LDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGYDKSKCPQGYPLHVYLLMGSFLLILVLVGLF--IFFWRRYKLEQELAAMSWKIRWEELDGEESQ 518
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 602.053 bits (1551), Expect = 0.000e+0 Identity = 302/547 (55.21%), Postives = 391/547 (71.48%), Query Frame = 2
Query: 1916 MSLVTISGVQLENI--QNTQVFIKTALFKGNIVALKKINTGRK----FETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVK---SSKHVPFRPSLDEI------DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
+S + SG +E I NTQ++ KTA+FKG +VA+KK+N K + ++ L+++KK+KDL +DHI RF G C++ H +V EYCPKGSLED+LENE+I LD + + SL+ D+V+G+ +LH S HG LKSSNCVVDSRFVLK+TDFGL+ L +++ N E H YYKKMLWT+PE+LR P +GT KGD+YSFAII E+++R+GVFA++N D P EIV+ V+ S P RP + E D + L+ ++ W EDP+ RP+ ++ ++R +++ E+ N++DNLL RMEQYANNLEGLV +RTQEYL EKK+ E+LL+ +LP ++A LI ++V AESY+ VTIYFSDIVGFTSLS+ STPMQV+ LLN LY FD +++NF VYKVETIGDAYMVVSGLP +HA +IA+M L L + FVI HRP+ QL+LRIG+HSG V AGVVG KMPRYCLFGDTVNTSSRMESNGLPLKIH+S T ++L F + RG VEMKGKG Q TYWL G D
Sbjct: 683 VSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDLS-PNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRD-DHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1227 HSP 2 Score: 183.726 bits (465), Expect = 1.098e-46 Identity = 150/508 (29.53%), Postives = 253/508 (49.80%), Query Frame = 2
Query: 239 NNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES---STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKW---------LPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKT--EGYKADASSLK---EIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLS-EFVFIHIDLFTGLNP-RPWF-DQKSSDEVNESVRNAFRSMLIVKLPLNS--EYWNSSIGNDLRKIAREKYNFSY---PKEELNYVTTSFYESIMLYALALNDLYAKNDTLD-----RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKD-GTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKR 1669
++G N + +S K+ P+ DLAL E++ ++G L N S+ L + +S + + + + +L + + IG +L +ARMS + + + G DK +YQ +TRI ++ +++ + L YKW P +G ++ S + +++ME N+ T E + A+ S + + R L+ S+M+ VII+C + R IMLAA ++ + S E+VFI+ID+ TG + +PW +++E NE + A+R++ + L + EY N + +++ A +KYN++ E+N ++FY++++LYA+ALN+ LD IT+ MW RTF G V ID G+R SD+SL DLDP F +V +Y+G++ + + W K PP D P C +D S C + L+ G L ++G+ F +RR K + EL AM+W I WE LD E +
Sbjct: 57 SDGKNPFLFSSHKVKPLADLAL---ERVYREGIL---PNNSVNLIYRDSKLSDAIGPNVAVEQ-----LLRKQIDCIIGYAYGYALAPVARMS-PYWKNGIPIITPIGLTMSLDDKREYQLMTRINSPYKVVSSAVSTLFNTYKWKRHIFMFHHAKAPSVAVGECFLLMASLQ---HPLRKVMEMQHNFFTFNEDHGANISKAERHNQFRNYLRASSNMANVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFEL--RVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSG--LDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTV--GQLHWVGGK--PPTDLPICGYDKSKCPQGYPLHVYLLMGSFLLILVLVGLF--IFFWRRYKLEQELAAMSWKIRWEELDGEESQ 539
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 556.984 bits (1434), Expect = 0.000e+0 Identity = 285/539 (52.88%), Postives = 379/539 (70.32%), Query Frame = 2
Query: 1916 MSLVTISGVQLENI--QNTQVFIKTALFKGNIVALKKINTGRK----FETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVK---SSKHVPFRPSLDEI------DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQT-----FIMSERGEVEMKGK 3469
+S + SG +E I NTQ++ KTA+FKG +VA+KK+N K + ++ L+++KK+KDL +DHI RF G C++ H +V EYCPKGSLED+LENE+I LD + + SL+ D+V+G+ +LH S HG LKSSNCVVDSRFVLK+TDFGL+ L +++ N E H YYKKMLWT+PE+LR P +GT KGD+YSFAII E+++R+GVFA++N D P EIV+ V+ S P RP + E D + L+ ++ W EDP+ RP+ ++ ++R +++ E+ N++DNLL RMEQYANNLEGLV +RTQEYL EKK+ E+LL+ +LP ++A LI ++V AESY+ VTIYFSDIVGFTSLS+ STPMQV+ LLN LY FD +++NF VYKVETIGDAYMVVSGLP +HA +IA+M L L + FVI HRP+ QL+LRIG+HSG V AGVVG KMPRYCLFGDTVNTSSRMESNGL + + S + K F+ F+ +E+ +E +GK
Sbjct: 94 VSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENEDL-SPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRD-DHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLRMFWNFSLYKIYKFKVFKNKIELDFLKNEKESIEFEGK 630
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-21 (Receptor-type guanylate cyclase gcy-21 [Source:UniProtKB/Swiss-Prot;Acc:O16715]) HSP 1 Score: 450.284 bits (1157), Expect = 1.382e-138 Identity = 267/706 (37.82%), Postives = 401/706 (56.80%), Query Frame = 2
Query: 1415 EGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQIS-RKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSN-YGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQT-LPFIGTV---KGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV---PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
EG SI++ N+ P DTP C F G C +T +I A+ + I F Y+R +++ L ++ ++I + ++K + SQ S R ++++ +++ + + ++ + N+ S I+ G + ++G + + L++G VALK+I E T+ + L+I K+++ N ++ F+GM V+ ++VYE +GSL+D+L+N+ + LD +FR + +DI+ G+ YLHS+ GCHG LKS+NC++D+R++++L+ FGL LR +E +E + K LWTSPE+LR T L G + K DVYS AI+ E+ R G + + +P+EIV VK PFRP + + + + + AW EDP NRP IK ++ + G + I+DN++S +E+Y + LE +A+R +E EK ++E LL MLP+ VA L +VSAES+E T++FSD GF +SA S P+ +++ LN LYT FD II+ FDVYKVETI DAYMV SGLP NG +HA EIA + L L A+ F I H PN ++ LRIG++SGP AGVVG KMPRYCLFGDTVNT+SRMESNG+PL+I+ S + E+L + + ERG VEMKGKGKQ+TY++ GEN
Sbjct: 345 EGLSIDFVNKS--APKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLAIAAAFLYKRYRYERRLHSLFFMIDRNQI-ILKKHTNLMSQQSLRSMASIHGSVV---------------------AASQTLRDSHFFIEDYNNASSINASSIFNTGSTARAGPFGPIPGFGGVTGASEDEKWHQIPDFGVGLYEGRTVALKRIYRS-DVEFTRSIRLEIAKLQESVNSNVIEFVGMVVQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHSSPIGCHGRLKSTNCLIDARWMVRLSSFGLRELR--GEETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLLVQKSDVYSLAIVLYELFGRLGPWG---DEPMEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQETVVAAWTEDPLNRPSLHQIKRKLKPLTIGLKR-TIMDNMVSMIEKYTDKLEKDIAERNEELEGEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFLNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGGYEIEERGIVEMKGKGKQMTYFVRGEN 1019
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG3216 (gene:FBgn0034568 transcript:FBtr0273396) HSP 1 Score: 620.157 bits (1598), Expect = 0.000e+0 Identity = 409/1129 (36.23%), Postives = 590/1129 (52.26%), Query Frame = 2
Query: 272 KKLGPITDLALARIEK----------LKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFE-----------------------FKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSL----KEIREK-LKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQ--KSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPK-EELNYVTTSFYESIMLYALALND-LYAKNDTLD--RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGF-FAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVE-PLHQYLVY-EYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFI--GTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
++ GP DLAL I K LKKKG S S + YF D V AFIGP +L +AR++ + +G+ E FKDK +Y LTR++ L +++ + W N +D + ++ + +E + EG + L +E+ E LK S +RV+I+ R MLAA + + E+VF+ +++F W D+ + DE + R A+ ++L V L + +++R+ A YN+++ + EE+N+ +FY+ + L +ALN+ L D D IT MWNRTF G V+ID G+R +D+S+ DLDP +G F V Y+G + YS + GK I W + EPP D P C F G+ G + +++ LF+ V +++K EL M+W + R D + E G GSK ++ D++ + + G H G AS S+ SL QV+ FKG VA+KK+N +K + T ++L +IK+ +D+++++ RF+G C++ P L+ EYC +GSL+D+LENE I LDW FR+SLI DIV+GM YLH S+ HG L+S NC++D RFVLK++DFGL L S+ YY K+LW +PE+L T+P T +GDVYSF II +EI+ R G + + D I+ V+ FRP + E + C DL++++++ W ++ RP F I++++R I KG N++D+LL+RMEQYANNLE LV ++T++ EK+R E+LLY +LP+ VA QL+ V E + VTIYFSDIVGFT L A S+PM V+ LN LY+TFD II +DVYKVETIGDAY+VVSGLP NG HAREIA M L L A+ F + H+P ++++RIG+HSG VCAGVVG KMP YCLFGDTVNT+SRMES G P KIH+S +T +L F TF M +RG+VE+KGKG TYWL+ ++
Sbjct: 106 ERCGPAVDLALDEINKVFLKPHNITLLKKKG--------------SYPSCSGARAPGLAADMYFQDD--VIAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNW------NHVALLVDRSEL--FSWTVGKNLEY--GLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQS---EYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRV-------------------RPDDVLIEM------------------GGMFGSKGGLQR------------LDVENISLQQFGIHSGRASIASFTSL------------PPQVYTTIGQFKGERVAIKKVNV-KKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTL----TTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQ-EARQQMDVHTILHKVRQCNG--FRPLIRERE-CPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGF-CENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSE 1134
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0346151) HSP 1 Score: 594.349 bits (1531), Expect = 0.000e+0 Identity = 305/539 (56.59%), Postives = 389/539 (72.17%), Query Frame = 2
Query: 1922 LVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGR-KFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHS-NYGCHGHLKSSNCVVDSRFVLKLTDFGLNILR----EIQKENSNEEPSHEYYKKMLWTSPEILRTQ-TLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCD-SKDPKEIVESVKS----SKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
+V+I+G + Q+FI +F+ + VA+K + + T+ ++L++K++KDL +DH+ +F G C++ +L+ EYCPKGSL+D+LENEQ LDWMFRLSL+ DIVRGM +LHS + HG+LKSSNCVVDSRFVLK+TDFGL+ LR +++ + N SH Y+ K+LWT+PE+LR + P GT KGDVY+F II EI R+G F + C K P+EI+E VK PFRP L+ +D+ II++ W EDP RPDF +K+ +R+ +K E+GNI+DNLL RME YANNLE LV +RTQ+Y EEKK+ E LLY +LP+SVA QLI Q V AE+++QVTIYFSDIVGFT++SA+STPMQV++ LN LYT FDSI+ENFDVYKVETIGDAYMVVSGLP NG HAREIAR+ L L A+ F I HRP +L+LRIG+H+G AGVVG KMPRYCLFGDTVNT+SRMESNG LKIHIS +T E L F TF+ + RG V MKGKG+ LTYWL GE
Sbjct: 601 MVSING-------DRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCN-SHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131 HSP 2 Score: 189.504 bits (480), Expect = 2.931e-48 Identity = 145/515 (28.16%), Postives = 254/515 (49.32%), Query Frame = 2
Query: 176 KKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEP-VHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQ-YQGLTRIAGNH-ESLTNFMGKLLKFYKWLPRPHKNIGVFYIDD----KSYSDYFYSAKEMMERLKNYKTE--GYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKL-DLSEFVFIHIDLFTG---LNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYP-KEELNYVTTSFYESIMLYALALNDLYAKNDT-LDRITN------YMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
++L R + V + S +E +N N+ I+ K+ P+ +LA+ ++++ G +++ ++L ++ S++ I FF P V+A G L I+R + L + G A EF K + Y LTR+ G +L N + +L + W + Y ++ K S F + + ++ + G+ + +I LK ++ SR++I+C + R IML A E+ + D E+VFI+I+LF+ L +PW+D+ +D NE + A+ +ML V K P ++EY + + N+++ IA EKYN+++ E ++ TSF++ ++LYA ALN+ ++ T L R N MWNR+F G V IDA G+R+S +SL D++P +G F+ V + + + K I W ++ E P D P C +DG+LC + I + V+ + FF YR +AE+ +M+W + E +
Sbjct: 78 RRLGARRQLVFVALLPS-VESDNKNDCIM---PKVLPVLELAIRHVQRMG----FVGGSHFDIQLISRDTFCSSKYGPI--GFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAK---EFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNW-----TRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEY--TRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFE--ANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDV 570
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0083187) HSP 1 Score: 594.349 bits (1531), Expect = 0.000e+0 Identity = 305/539 (56.59%), Postives = 389/539 (72.17%), Query Frame = 2
Query: 1922 LVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGR-KFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHS-NYGCHGHLKSSNCVVDSRFVLKLTDFGLNILR----EIQKENSNEEPSHEYYKKMLWTSPEILRTQ-TLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCD-SKDPKEIVESVKS----SKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
+V+I+G + Q+FI +F+ + VA+K + + T+ ++L++K++KDL +DH+ +F G C++ +L+ EYCPKGSL+D+LENEQ LDWMFRLSL+ DIVRGM +LHS + HG+LKSSNCVVDSRFVLK+TDFGL+ LR +++ + N SH Y+ K+LWT+PE+LR + P GT KGDVY+F II EI R+G F + C K P+EI+E VK PFRP L+ +D+ II++ W EDP RPDF +K+ +R+ +K E+GNI+DNLL RME YANNLE LV +RTQ+Y EEKK+ E LLY +LP+SVA QLI Q V AE+++QVTIYFSDIVGFT++SA+STPMQV++ LN LYT FDSI+ENFDVYKVETIGDAYMVVSGLP NG HAREIAR+ L L A+ F I HRP +L+LRIG+H+G AGVVG KMPRYCLFGDTVNT+SRMESNG LKIHIS +T E L F TF+ + RG V MKGKG+ LTYWL GE
Sbjct: 601 MVSING-------DRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCN-SHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131 HSP 2 Score: 189.504 bits (480), Expect = 2.931e-48 Identity = 145/515 (28.16%), Postives = 254/515 (49.32%), Query Frame = 2
Query: 176 KKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEP-VHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQ-YQGLTRIAGNH-ESLTNFMGKLLKFYKWLPRPHKNIGVFYIDD----KSYSDYFYSAKEMMERLKNYKTE--GYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKL-DLSEFVFIHIDLFTG---LNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYP-KEELNYVTTSFYESIMLYALALNDLYAKNDT-LDRITN------YMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
++L R + V + S +E +N N+ I+ K+ P+ +LA+ ++++ G +++ ++L ++ S++ I FF P V+A G L I+R + L + G A EF K + Y LTR+ G +L N + +L + W + Y ++ K S F + + ++ + G+ + +I LK ++ SR++I+C + R IML A E+ + D E+VFI+I+LF+ L +PW+D+ +D NE + A+ +ML V K P ++EY + + N+++ IA EKYN+++ E ++ TSF++ ++LYA ALN+ ++ T L R N MWNR+F G V IDA G+R+S +SL D++P +G F+ V + + + K I W ++ E P D P C +DG+LC + I + V+ + FF YR +AE+ +M+W + E +
Sbjct: 78 RRLGARRQLVFVALLPS-VESDNKNDCIM---PKVLPVLELAIRHVQRMG----FVGGSHFDIQLISRDTFCSSKYGPI--GFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAK---EFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNW-----TRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEY--TRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFE--ANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDV 570
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304791) HSP 1 Score: 508.834 bits (1309), Expect = 4.212e-159 Identity = 264/536 (49.25%), Postives = 358/536 (66.79%), Query Frame = 2
Query: 1919 SLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYK--KMLWTSPEILRTQTLPFI-GTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV--PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
S V++S + + T +F L+KG + A+KK+ + + T+EM ++K ++D +D+IC FIG C +P + ++ EYC +GSL+D+LENE + LD MF S++ DI+RG+IYLH S HG L +SNC+VDSR+V+KLTDFGL ++ E+S+ + H K K+L+ +PE+LR + GT +GD YSF I+ E+ RRG F P + ++ V + P+RPSL ++ + + +++ W E P +RPDF I+ +R + KG NI DN+++ ME+YANNLE LV RT + EEKK+ + LL+ MLP+ VA QL K V E YEQV+IYFSDIVGFT++SA+ TP+QV++ LN LYT FDSII ++DVYKVETIGDAYMVVSGLP NG HA EIA M L LSA+ F I HRP +L LRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMES+G+PLKIH S ++L + +ERG + MKGKG Q TYWL GE++
Sbjct: 560 SQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRK-KSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQ-GIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLT---PMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRP-NIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1089
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304792) HSP 1 Score: 508.449 bits (1308), Expect = 4.243e-159 Identity = 264/536 (49.25%), Postives = 358/536 (66.79%), Query Frame = 2
Query: 1919 SLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYK--KMLWTSPEILRTQTLPFI-GTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV--PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
S V++S + + T +F L+KG + A+KK+ + + T+EM ++K ++D +D+IC FIG C +P + ++ EYC +GSL+D+LENE + LD MF S++ DI+RG+IYLH S HG L +SNC+VDSR+V+KLTDFGL ++ E+S+ + H K K+L+ +PE+LR + GT +GD YSF I+ E+ RRG F P + ++ V + P+RPSL ++ + + +++ W E P +RPDF I+ +R + KG NI DN+++ ME+YANNLE LV RT + EEKK+ + LL+ MLP+ VA QL K V E YEQV+IYFSDIVGFT++SA+ TP+QV++ LN LYT FDSII ++DVYKVETIGDAYMVVSGLP NG HA EIA M L LSA+ F I HRP +L LRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMES+G+PLKIH S ++L + +ERG + MKGKG Q TYWL GE++
Sbjct: 558 SQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRK-KSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQ-GIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLT---PMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRP-NIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1087
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4]) HSP 1 Score: 713.761 bits (1841), Expect = 0.000e+0 Identity = 404/895 (45.14%), Postives = 549/895 (61.34%), Query Frame = 2
Query: 854 IIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT-GLNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR-----ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
+ +C + R +++ + L E+VF +ID+F RP D + + AF+S+ I+ P N EY DL+ A+ +NF+ +N ++ FY+ +MLY ALN+ + +D+ +R ++ MWNRT+ G V+ID G+R +DF+L+D+ D +G+FQ V YNG+ + +++ G +I+W K P+D P C F + C+ + + + +I F YR+LK + EL A W I W+ + Q+S + + T GSK + + RGS +Y SL+T G N QVF KT FKGNIVA+K IN R+ E T+++L ++K ++D+ N+H+ RFIG C++P + +V EYCP+GSL+++LEN+ I LDWMF+ SLI DIV+GM +LH S HG+LKSSNCVVD+RFVLK+TD+GL+ +R S+ E +H YY + LW +PE+ R + P GT KGDVYSF II QE+ RRGVF ++ D PKEIV+ V + RPSL+ S +L +++++ W E+P++RP+F I +RK ++ S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H REIARM L L A+ F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S +T VL+ F F + RG+VEMKGKGK TYWL GE
Sbjct: 2 VFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAKEAFQSVKILTYLEPQNQEY--KDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNE--SLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPGGK--VPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDI-----------QMSHLEKALRST----------------------GSKLTLSL--------------------------RGS----NYGSLLTTDG-------NFQVFAKTGYFKGNIVAIKYINR-RRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRT----ESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEG-DLLSPKEIVDRVALGEWPYLRPSLNP-QAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNREHRS-NILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 812
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4]) HSP 1 Score: 697.582 bits (1799), Expect = 0.000e+0 Identity = 418/1043 (40.08%), Postives = 594/1043 (56.95%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMER-----LKNYKTEGYKADASSLKEIREK----------LKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT-GLNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR-----ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
AFIGP + + + + +++ G F + ++ Y +T H+ L + L + + W +S +S +M ER L+ TE ++ + +++ + E+ L + RV+ +C + R +++ + L E+VF +ID+F RP D + + AF+S+ I+ P N EY DL+ A+ +NF+ +N ++ FY+ +MLY ALN+ + +D+ +R ++ MWNRT+ G V+ID G+R +DF+L+D+ D +G+FQ V YNG+ + +++ G +I+W K P+D P C F + C+ + + + +I F YR+LK + EL A W I W+ + Q+S + + T GSK + + RGS +Y SL+T G N QVF KT FKGNIVA+K IN R+ E T+++L ++K ++D+ N+H+ RFIG C++P + +V EYCP+GSL+++LEN+ I LDWMF+ SLI DIV+GM +LH S HG+LKSSNCVVD+RFVLK+TD+GL+ +R S+ E +H YY + LW +PE+ R + P GT KGDVYSF II QE+ RRGVF ++ D PKEIV+ V + RPSL+ S +L +++++ W E+P++RP+F I +RK ++ +I+ + QYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H REIARM L L A+ F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S +T VL+ F F + RG+VEMKGKGK TYWL GE
Sbjct: 125 AFIGPGCDYTSSPVGLFTA-HWGLPMITAGAPAVAF-LQMEI-YTSITNTGPTHKKLGEYALHLYRHFGW---------------NQHSLLMFSDTKMGERACYFALEGLYTEMHEENITTMDLVFEENKGPVNYSELLHKIQGDGRVVFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAKEAFQSVKILTYLEPQNQEY--KDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNE--SLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPGGK--VPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDI-----------QMSHLEKALRST----------------------GSKLTLSL--------------------------RGS----NYGSLLTTDG-------NFQVFAKTGYFKGNIVAIKYINR-RRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRT----ESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEG-DLLSPKEIVDRVALGEWPYLRPSLNP-QAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNRSVPHYSIV------LSQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1060
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:dkey-37g12.1 (si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-145]) HSP 1 Score: 643.269 bits (1658), Expect = 0.000e+0 Identity = 402/1034 (38.88%), Postives = 561/1034 (54.26%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKE-----IREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYP---KEELNYVTTSFYESIMLYALALNDLYAKN----DTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLC----KKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYL-HSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
AFIGP+ A+++ +N +++S A QF DK Y LTR+ G L F ++ K + W ++IG+ Y +++ K E N Y+ SSL + L ++ ++R+I+I K R +++ A + L +FVF + + FD + D + + A++++ + L S+ + ++ I+R K +F Y E+++ + ++++ LYA ALN+ A+N D L +T MWNRT G V IDA G+R ++ + + + Q V Y G TY ++G I W PP D+P C F G LC +K + G+I G A I V+ YR+ K E M W I + + V +H S + K +S Q S E I D A R ++G TI V N+++T + E+L ++K+ +DL + ++C+FIG +E +++ EYCPKGSL+D+L+NE I LDW F+ SL+ DIV+GM YL HS HGHL SS+CVVDSRFVLK+TDFGLN +R + E S P + + +LW +PE+LR Q++P GT KGDVYSFAIIAQE++YRRG F + N P+EIVE V++ P RP +D + C +L ++ W E P RPDF I+ +++K S NILD+LLSRMEQYA NLE +V++RT E EEKKRAE LL MLP+SVA QLI ++V AE+Y+ VTIYFSDI GFT++SA TPMQV+ +LN LYT FD+II+ +VYKVETIGDAYMVVSGLP NG +HA+EIARM L + + F PH P QL +RIGVHSGP AGVVG KMPRYCLFGDTVNT+SRMES GLPLKIH+S ST +L +F+ F RG++ +KGKG T+WL GE+
Sbjct: 92 AFIGPSCSNVCAVTAKLAAF-WNIAVISPVCADQQF--LDKKAYPTLTRVFGPFTKLGAFFVEICKQFGW-----QHIGIIYDGKPTWAIPVEGIKYQAEH-NNITVAKYQDIHSSLSQGSTSNWSRVLNEMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFEPYKQKVLFGSFDWEQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAFSENV--ISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYAHALNETLAENGNPYDGL-AVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANYFG---TYKAVKGVQILWPGGLTSPPKDSPDCGFRGELCINLERKFLIALGIIAGLMAAGTLAICVL-----YRKYKLPEEASKMLWTI---NANDVIMMEHHSSTVPEKSH---------------------RSKPLQASLESIICSMQ------------DKPSAHRTAVYKG-----------TICSVSFVNLRSTHL-------------------------NSELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVRRLDTEQS---PGSDPWTALLWRAPELLR-QSIPANGTQKGDVYSFAIIAQEVVYRRGPFYIPN-SHFSPREIVERVRAGGCSPSRPYIDRAE-CVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKGKGWVRTFWLLGED 1027
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:dkey-37g12.1 (si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-145]) HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0 Identity = 394/1020 (38.63%), Postives = 551/1020 (54.02%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKE-----IREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYP---KEELNYVTTSFYESIMLYALALNDLYAKN----DTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLC----KKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYL-HSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMK 3463
AFIGP+ A+++ +N +++S A QF DK Y LTR+ G L F ++ K + W ++IG+ Y +++ K E N Y+ SSL + L ++ ++R+I+I K R +++ A + L +FVF + + FD + D + + A++++ + L S+ + ++ I+R K +F Y E+++ + ++++ LYA ALN+ A+N D L +T MWNRT G V IDA G+R ++ + + + Q V Y G TY ++G I W PP D+P C F G LC +K + G+I G A I V+ YR+ K E M W I + + V +H S + K +S Q S E I D A R ++G TI V N+++T + E+L ++K+ +DL + ++C+FIG +E +++ EYCPKGSL+D+L+NE I LDW F+ SL+ DIV+GM YL HS HGHL SS+CVVDSRFVLK+TDFGLN +R + E S P + + +LW +PE+LR Q++P GT KGDVYSFAIIAQE++YRRG F + N P+EIVE V++ P RP +D + C +L ++ W E P RPDF I+ +++K S NILD+LLSRMEQYA NLE +V++RT E EEKKRAE LL MLP+SVA QLI ++V AE+Y+ VTIYFSDI GFT++SA TPMQV+ +LN LYT FD+II+ +VYKVETIGDAYMVVSGLP NG +HA+EIARM L + + F PH P QL +RIGVHSGP AGVVG KMPRYCLFGDTVNT+SRMES GLPLKIH+S ST +L +F+ F RG++ +K
Sbjct: 92 AFIGPSCSNVCAVTAKLAAF-WNIAVISPVCADQQF--LDKKAYPTLTRVFGPFTKLGAFFVEICKQFGW-----QHIGIIYDGKPTWAIPVEGIKYQAEH-NNITVAKYQDIHSSLSQGSTSNWSRVLNEMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFEPYKQKVLFGSFDWEQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAFSENV--ISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYAHALNETLAENGNPYDGL-AVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANYFG---TYKAVKGVQILWPGGLTSPPKDSPDCGFRGELCINLERKFLIALGIIAGLMAAGTLAICVL-----YRKYKLPEEASKMLWTI---NANDVIMMEHHSSTVPEKSH---------------------RSKPLQASLESIICSMQ------------DKPSAHRTAVYKG-----------TICSVSFVNLRSTHL-------------------------NSELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVRRLDTEQS---PGSDPWTALLWRAPELLR-QSIPANGTQKGDVYSFAIIAQEVVYRRGPFYIPN-SHFSPREIVERVRAGGCSPSRPYIDRAE-CVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIK 1013
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr2 (natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZDB-GENE-141030-2]) HSP 1 Score: 601.668 bits (1550), Expect = 0.000e+0 Identity = 309/537 (57.54%), Postives = 383/537 (71.32%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
S SY SL+T G Q+F KT FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RFIG C++P + +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM YLH++Y G HG+LKSSNCVVDSRFVLK+TD+GL R + E SH Y K LWT+PE+L P GT KGDVYSF II QEI R G F V+ D PKEI++ V++ + FRP+ D C +L +++ W EDP RPDF IK + K +K + L LSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HAREIA M L L + F I HRPN QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMES G L+IH+S +T EVL F F + RG+VEMKGKGK TYWL GE
Sbjct: 525 SQRGSSYGSLITAHG-------KYQLFAKTGYFKGNLVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCENEDSHALYAKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVEGMD-LSPKEIIQKVRNGQKPYFRPTTDNSRHCE-ELTILMEGCWSEDPAERPDFSHIKVFIAKFNKQHQYSQYL---LSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFELQLRGDVEMKGKGKMRTYWLLGE 1044 HSP 2 Score: 140.198 bits (352), Expect = 4.708e-33 Identity = 126/475 (26.53%), Postives = 220/475 (46.32%), Query Frame = 2
Query: 314 EKLKKKGELQGFANYSLKLFFSESS-TVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYS-AKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGA-SKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYA----KNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
EK++K G L+G L +SS + SE++ + + +P AFIGP S+ ++ R + + + L++ G Y F+ + +++ + R + L +F+ L + W R DD+ + YF S + R +N + + ++ + + R++ ICG + +++ L E+K ++ ++D+F +G P PW Q S + N+ ++ F+S+ +V P + EY ++ +L K A + +N ++++ F++ +LYA AL++ A +ND ++ IT M NR G V ID + R +DFSL+ + + KSG + VG YNG+++ + I+W K PPLD P C F S CK+D I + +I I F YR+LK + EL M W I WE L K+ + SR
Sbjct: 64 EKIQKSGLLRGHTINLLNFSTEDSSGSCSENEAQIIAVDTKLYHKP-DAFIGPGCTYSVASVGRFA-SHWKLPLITAGGPAYGFDKWE--EFKTIVRTGPTTKKLGDFVNYLHGQFNWSSRALMIFHDLKQDDRPH--YFLSEGIYTVLREENITVLAFPYEDEQTYNYKDMITFIKDNGRIVYICGPLPTFFQIMKLFEDEVK-SPEDYAIFYLDVFAESLSGDVPMPW--QGSDIQWNDPIK-LFQSVFVVTYQEPDSPEY--TAFRKELHKRAIQDFNVQLEPSMMDFIAGCFHDGFVLYAKALSEALADGVSQNDGIN-ITARMQNRRLWGVTGLVSIDQKNARFTDFSLWAMTNLKSGQYAIVGHYNGTSKEILWSPTEKIQW--PKGCPPLDYPPCGF--SPCKEDHLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWEELQFESPNKYHKRAGSR 521
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 593.578 bits (1529), Expect = 0.000e+0 Identity = 308/533 (57.79%), Postives = 387/533 (72.61%), Query Frame = 2
Query: 1874 RNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
R K RGS SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RF+G C++P + +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S G HG+LKSSNCVVDSRFVLK+TD+GL R + + ++ Y K LWT+PE+LR P GT KGDVYSF II QEI R G F + D PKEIV+ V++ + FRP++D I S +L ++ + W E+P +RPDF IK + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H REIARM L L A+ F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG L+IHIS +T EVL F F + RG++EMK K
Sbjct: 87 RYHKTRGS----SYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 600
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 593.193 bits (1528), Expect = 0.000e+0 Identity = 304/526 (57.79%), Postives = 383/526 (72.81%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RF+G C++P + +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S G HG+LKSSNCVVDSRFVLK+TD+GL R + + ++ Y K LWT+PE+LR P GT KGDVYSF II QEI R G F + D PKEIV+ V++ + FRP++D I S +L ++ + W E+P +RPDF IK + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H REIARM L L A+ F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG L+IHIS +T EVL F F + RG++EMK K
Sbjct: 167 SLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 677
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 593.193 bits (1528), Expect = 0.000e+0 Identity = 304/526 (57.79%), Postives = 383/526 (72.81%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RF+G C++P + +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S G HG+LKSSNCVVDSRFVLK+TD+GL R + + ++ Y K LWT+PE+LR P GT KGDVYSF II QEI R G F + D PKEIV+ V++ + FRP++D I S +L ++ + W E+P +RPDF IK + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H REIARM L L A+ F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG L+IHIS +T EVL F F + RG++EMK K
Sbjct: 37 SLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 547
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 592.808 bits (1527), Expect = 0.000e+0 Identity = 304/526 (57.79%), Postives = 383/526 (72.81%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RF+G C++P + +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S G HG+LKSSNCVVDSRFVLK+TD+GL R + + ++ Y K LWT+PE+LR P GT KGDVYSF II QEI R G F + D PKEIV+ V++ + FRP++D I S +L ++ + W E+P +RPDF IK + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H REIARM L L A+ F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG L+IHIS +T EVL F F + RG++EMK K
Sbjct: 122 SLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 632
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 592.808 bits (1527), Expect = 0.000e+0 Identity = 304/526 (57.79%), Postives = 383/526 (72.81%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGK 3469
S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RF+G C++P + +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH S G HG+LKSSNCVVDSRFVLK+TD+GL R + + ++ Y K LWT+PE+LR P GT KGDVYSF II QEI R G F + D PKEIV+ V++ + FRP++D I S +L ++ + W E+P +RPDF IK + K +K + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H REIARM L L A+ F I HRPNTQL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG L+IHIS +T EVL F F + RG++EMK K
Sbjct: 195 SLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPYFRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNK-EGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 705
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr1 (natriuretic peptide receptor 1 [Source:MGI Symbol;Acc:MGI:97371]) HSP 1 Score: 621.313 bits (1601), Expect = 0.000e+0 Identity = 308/537 (57.36%), Postives = 392/537 (73.00%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSN-YGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
S +Y SL+T G QVF KTA +KGN+VA+K++N ++ E T+++L ++K ++D+ N+H+ RF+G C +P + ++ EYCP+GSL+D+LENE I LDWMFR SL DIV+GM++LH+ G HG+LKSSNCVVD RFVLK+TD+GL R+ + E H + K LWT+PE+LR + P G+ GDVYSF II QEI R GVF V+ D PKEI+E V + PFRPS+D + +L +++++ W EDP RP F I+ ++RK +K + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP NG+ HARE+ARM L L A+ F I HRP QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG L+IH+S T VL+ F F + RG+VEMKGKGK TYWL GE
Sbjct: 530 SGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQG-----HTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLS-PKEIIERVTRGEQPPFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNK-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050 HSP 2 Score: 166.392 bits (420), Expect = 3.388e-41 Identity = 134/500 (26.80%), Postives = 227/500 (45.40%), Query Frame = 2
Query: 275 KLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES---STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYID----DKS----YSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF-------TGLNPR-PWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGS--LCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
++GP +LAL R+ K + +L +++++ S + V + F+GP + S + R + + L++ G KD +Y TR +H L +F+ L + W H+ + V Y D D+ + +E + N++ E + D ++ L+ + RVI IC + R +ML A++ L ++VF H+D+F G PR PW + D + R AF++ I+ K P N EY L+ +A +K+NF+ N + SF++ ++LY A+ + A+ T+ + IT MWNR+F G +KID G+R +DFSL+D+DP++G F+ V +NG+++ + + W PP D PKC FD C +D ST + + V +I FF YR+++ + EL + W + WE L +H +S SR
Sbjct: 50 RVGPAVELALGRV---KARPDL--LPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTA-HWRVPLLTAGAPALGIGVKD--EYALTTRTGPSHVKLGDFVTALHRRLGW---EHQAL-VLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQ-EFVEGDPDHYTKL---LRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPW---ERDDGQDRRARQAFQAAKIITYKEPDNPEYLE--FLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSR 526
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 609.372 bits (1570), Expect = 0.000e+0 Identity = 312/551 (56.62%), Postives = 392/551 (71.14%), Query Frame = 2
Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
H+G+ S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RFIG C++P + +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++ HG LKSSNCVVDSRFVLK+TD+GL R S EP SH Y K LWT+PE+L LP G K DVYSFAII QEI R G F ++ D PKEIV+ V++ + FRPS+D + +L+ ++++ W +DP RPDF IK +R+ +K E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HA EIARM L L A+ F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S +T + L F + RG+VEMKGKGK TYWL GE
Sbjct: 508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLS-PKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQ 1040 HSP 2 Score: 151.754 bits (382), Expect = 1.150e-36 Identity = 113/431 (26.22%), Postives = 196/431 (45.48%), Query Frame = 2
Query: 458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLKNYK-TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
+GP + ++AR + + + L++ G F K++ Y+ L R + L F+ L + W R + Y+D ++ ++++ + + E L+ + ++ A + + + R++ ICG + I+L A L ++VF ++D+F T RPW D ++ ++ +++R AF+++L++ + P N EY N L ARE + +N + FY+ I+LYA LN+ + T + RI M R ++G V +D +R +DF L+ + D SG+FQ Y+G+ E G+ I W K PPLD P CAFD C K ST I T F++ + F +R+L + EL +M W I WE L ++ + SR
Sbjct: 96 LLGPGCVYPAASVARFA-SHWRLPLLTAGAVASGFAAKNE-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSR 514
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 608.601 bits (1568), Expect = 0.000e+0 Identity = 312/551 (56.62%), Postives = 392/551 (71.14%), Query Frame = 2
Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
H+G+ S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RFIG C++P + +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++ HG LKSSNCVVDSRFVLK+TD+GL R S EP SH Y K LWT+PE+L LP G K DVYSFAII QEI R G F ++ D PKEIV+ V++ + FRPS+D + +L+ ++++ W +DP RPDF IK +R+ +K E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HA EIARM L L A+ F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S +T + L F + RG+VEMKGKGK TYWL GE
Sbjct: 74 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQ 606
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 497.664 bits (1280), Expect = 6.183e-157 Identity = 259/474 (54.64%), Postives = 333/474 (70.25%), Query Frame = 2
Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSG 3274
H+G+ S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RFIG C++P + +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++ HG LKSSNCVVDSRFVLK+TD+GL R S EP SH Y K LWT+PE+L LP G K DVYSFAII QEI R G F ++ D PKEIV+ V++ + FRPS+D + +L+ ++++ W +DP RPDF IK +R+ +K E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HA EIARM L L A+ F I HRP+ QL LRIGVH+G
Sbjct: 508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLS-PKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 963 HSP 2 Score: 151.369 bits (381), Expect = 1.416e-36 Identity = 113/431 (26.22%), Postives = 196/431 (45.48%), Query Frame = 2
Query: 458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLKNYK-TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
+GP + ++AR + + + L++ G F K++ Y+ L R + L F+ L + W R + Y+D ++ ++++ + + E L+ + ++ A + + + R++ ICG + I+L A L ++VF ++D+F T RPW D ++ ++ +++R AF+++L++ + P N EY N L ARE + +N + FY+ I+LYA LN+ + T + RI M R ++G V +D +R +DF L+ + D SG+FQ Y+G+ E G+ I W K PPLD P CAFD C K ST I T F++ + F +R+L + EL +M W I WE L ++ + SR
Sbjct: 96 LLGPGCVYPAASVARFA-SHWRLPLLTAGAVASGFAAKNE-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSR 514
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2g (guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:106025]) HSP 1 Score: 446.817 bits (1148), Expect = 3.280e-137 Identity = 250/560 (44.64%), Postives = 361/560 (64.46%), Query Frame = 2
Query: 1886 HRG---SASNESYMSLVTIS---GVQLENIQNTQVFIK-TALFKGNIVALKKINTGRKFETTKEMLL-DIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENS-NEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKH-VPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPE 3532
HRG S N S S V S G ++ Q+ ++F L++GN VAL I + K + ++ + +L +++I F G+C EP + +V +YC KGSL+D++ N +DW+F+LS DIV G+++LH S HG+LK SNC+VDS LKL+ FGL + S N+E + + ++ WT+PE+LR + P GT +GDVYSFAI+ +++I+++ ++ ++ P+EI+ +K + VP RPSL E G ++ ++++ WDE P RP FP IK ++R+ + +ILD+++ ++E YAN+LE +V +RT+E + EK++ E LL +MLP V QLI +SV E +E VTI+FSDIVGFT L + S+P+QV++LLN LY+ FD I++ DVYKVETIGDAYMV SGLP NG HA EIA M L LS F I H P +L+LRIG+H+GPV AGVVG MPRYCLFGDTVN +SRMES+ LPL+IH+S ST L + + + +RG + +KGKG+Q T+WL G++ F V P+PE
Sbjct: 535 HRGTPVSRRNVSDTSTVKASADCGSLVKRHQDEELFFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATD--HSELYWTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQAHGPFEDLEAA-PEEIISRIKDPRAPVPLRPSLLEDKG-DGRIVALVRECWDESPELRPIFPSIKKTLREASP-RGHVSILDSMMGKLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWLKGKDGFPV-PLPE 1088 HSP 2 Score: 81.6481 bits (200), Expect = 4.793e-15 Identity = 114/500 (22.80%), Postives = 204/500 (40.80%), Query Frame = 2
Query: 323 KKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVF--YIDDKSYS--DYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGND-LRK-----IAREKYNFSYPKE-ELNYVTTSFYESIMLYALALNDLY-AKNDTLDR----ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEP------PLDTPKCAFDGSLCKKDG--------TSTGLIFGCTTAALFVIGVIGGFFAYR-RLKFQAELKAMNWIIPWESLDTVEKRK--HRQSQISRKDSTVNETL 1723
K E G N S + ++ S+ ++ + F + E + A GP + I ++ + +N L G KD + + ++ + + L++ W ++IGVF D S+ D + A E + T + ++SS ++E L+ +S ++RVII+ +S+ R I+ AAV++ LD EFVFI L L W + + D+V + S+ ++ + IG+D RK + R + S E +++ + +++++LYA + ++ A+ D D T T G PV +D++G R D+S++ L + F + Y + W N+ N P P C F LCK T T +I T L I G +R R K Q+ W I ++S+ + + K HR + +SR++ + T+
Sbjct: 75 KLNSEPVGLGNVSWEFTYTNSTCSAKES--LAVFIDQVQKEHISALFGPACPEAAEVIGLLA-SEWNIPLFDF--VGQMAALKDHFWCDTCVTLVPPKQEISAVLRESLRYLGW-----EHIGVFGGSSADSSWEQVDEMWGAVEDGLQFHFNITASMRYNSSSSDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLGLDTGEFVFI---LLQQLEDSFWKEVLTKDKVIR-FPKVYESVFLIA----PSAYGGGIGDDGFRKQVSQELRRPPFQSSITSEDQVSPYSAYLHDALLLYAQTVEEMRKAEKDFRDGRQLISTLRAGQVTLQGITGPVLLDSQGKRHVDYSVYALQESGNRSLFLPFLH-----YDSFQKVIRPWRNDSNTSWPHGSLPEYKPGCGFHNDLCKTKPPTVAGMTVTVTAVIPTVTFLVLASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSITLLPQHKLSHRGTPVSRRNVSDTSTV 551
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18910|ANPRA_RAT (Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus OX=10116 GN=Npr1 PE=1 SV=1) HSP 1 Score: 622.083 bits (1603), Expect = 0.000e+0 Identity = 309/537 (57.54%), Postives = 392/537 (73.00%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGC-HGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
S +Y SL+T G QVF KTA +KGN+VA+K++N ++ E T+++L ++K ++D+ N+H+ RF+G C +P + ++ EYCP+GSL+D+LENE I LDWMFR SL DIV+GM++LH+ C HG+LKSSNCVVD RFVLK+TD+GL R+ + E H + K LWT+PE+LR + P G+ GDVYSF II QEI R GVF V+ D PKEI+E V + PFRPS+D + +L +++++ W EDP RP F I+ ++RK +K + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP NG+ HARE+ARM L L A+ F I HRP QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S T VL+ F F + RG+VEMKGKGK TYWL GE
Sbjct: 530 SGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQG-----HTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLS-PKEIIERVTRGEQPPFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNK-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050 HSP 2 Score: 171.014 bits (432), Expect = 8.511e-42 Identity = 136/500 (27.20%), Postives = 229/500 (45.80%), Query Frame = 2
Query: 275 KLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES---STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYID----DKS----YSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF-------TGLNP-RPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGS--LCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
++GP +LALAR+ K + +L +++++ S + V + F+GP + S + R + + L++ G KD +Y TR +H L +F+ L + W H+ + V Y D D+ + +E + N++ E + D ++ L+ + RVI IC + R +ML A+ L ++VF H+D+F GL P +PW + D + S R AF++ I+ K P N EY L+ +A +K+NF+ N + SF++ ++LY A+ + A+ T+ + IT MWNR+F G +KID G+R +DFSL+D+DP++G F+ V YNG+++ + + W PP D PKC FD C +D ST + + + +I FF YR+++ + EL + W + WE L +H +S SR
Sbjct: 50 RVGPAVELALARV---KARPDL--LPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTA-HWRVPLLTAGAPALGIGVKD--EYALTTRTGPSHVKLGDFVTALHRRLGW---EHQAL-VLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQ-EFVEGDPDHYPKL---LRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPW---ERGDGQDRSARQAFQAAKIITYKEPDNPEYLE--FLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYW--PLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSR 526
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18293|ANPRA_MOUSE (Atrial natriuretic peptide receptor 1 OS=Mus musculus OX=10090 GN=Npr1 PE=1 SV=2) HSP 1 Score: 621.313 bits (1601), Expect = 0.000e+0 Identity = 308/537 (57.36%), Postives = 392/537 (73.00%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSN-YGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
S +Y SL+T G QVF KTA +KGN+VA+K++N ++ E T+++L ++K ++D+ N+H+ RF+G C +P + ++ EYCP+GSL+D+LENE I LDWMFR SL DIV+GM++LH+ G HG+LKSSNCVVD RFVLK+TD+GL R+ + E H + K LWT+PE+LR + P G+ GDVYSF II QEI R GVF V+ D PKEI+E V + PFRPS+D + +L +++++ W EDP RP F I+ ++RK +K + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP NG+ HARE+ARM L L A+ F I HRP QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG L+IH+S T VL+ F F + RG+VEMKGKGK TYWL GE
Sbjct: 530 SGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQG-----HTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLS-PKEIIERVTRGEQPPFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNK-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050 HSP 2 Score: 166.392 bits (420), Expect = 2.370e-40 Identity = 134/500 (26.80%), Postives = 227/500 (45.40%), Query Frame = 2
Query: 275 KLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES---STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYID----DKS----YSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF-------TGLNPR-PWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGS--LCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
++GP +LAL R+ K + +L +++++ S + V + F+GP + S + R + + L++ G KD +Y TR +H L +F+ L + W H+ + V Y D D+ + +E + N++ E + D ++ L+ + RVI IC + R +ML A++ L ++VF H+D+F G PR PW + D + R AF++ I+ K P N EY L+ +A +K+NF+ N + SF++ ++LY A+ + A+ T+ + IT MWNR+F G +KID G+R +DFSL+D+DP++G F+ V +NG+++ + + W PP D PKC FD C +D ST + + V +I FF YR+++ + EL + W + WE L +H +S SR
Sbjct: 50 RVGPAVELALGRV---KARPDL--LPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTA-HWRVPLLTAGAPALGIGVKD--EYALTTRTGPSHVKLGDFVTALHRRLGW---EHQAL-VLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQ-EFVEGDPDHYTKL---LRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPW---ERDDGQDRRARQAFQAAKIITYKEPDNPEYLE--FLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSR 526
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16066|ANPRA_HUMAN (Atrial natriuretic peptide receptor 1 OS=Homo sapiens OX=9606 GN=NPR1 PE=1 SV=1) HSP 1 Score: 619.772 bits (1597), Expect = 0.000e+0 Identity = 313/557 (56.19%), Postives = 397/557 (71.27%), Query Frame = 2
Query: 1850 DIDPMVAIRNGKHRGS-----ASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGC-HGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
D++P R+ + GS +Y SL+T G QVF KTA +KGN+VA+K++N ++ E T+++L ++K ++D+ N+H+ RF+G C +P + ++ EYCP+GSL+D+LENE I LDWMFR SL DIV+GM++LH+ C HG+LKSSNCVVD RFVLK+TD+GL R++ E H Y K LWT+PE+LR + P G+ GDVYSF II QEI R GVF V+ D PKEI+E V + PFRPSL + +L ++++ W EDP RP F I+ ++RK ++ + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP NGR HA E+ARM L L A+ F I HRP QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S T VL+ F F + RG+VEMKGKGK TYWL GE
Sbjct: 514 DVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEG-------QFQVFAKTAYYKGNLVAVKRVNR-KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQG-----HTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLD-LSPKEIIERVTRGEQPPFRPSL-ALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNR-ENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054 HSP 2 Score: 179.874 bits (455), Expect = 1.698e-44 Identity = 122/429 (28.44%), Postives = 208/429 (48.48%), Query Frame = 2
Query: 458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLK---NYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT-----GLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDG--SLCKKDGTSTGLIFGCTTAALFVIGV-IGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
F+GP + + + R + + L++ G F KD +Y TR ++ L +F+ L + W R + + D+ + F+ + + R++ N + + L L+ + RVI IC + R +ML A+E L ++VF H+D+F G P P + D + S R AF++ I+ K P N EY L+ +A E++NF+ +N + SF++ ++LY A+ + A T+ + IT MWNR+F G +KID+ G+R +DFSL+D+DP++G F+ V YNG+++ + G+ + W PP D PKC FD C +D ST + +L ++G+ I FF YR+++ + EL + W + WE ++ +H +S SR
Sbjct: 113 FLGPGCVYAAAPVGRFT-AHWRVPLLTAGAPALGFGVKD--EYALTTRAGPSYAKLGDFVAALHRRLGW-ERQALMLYAYRPGDEEHC--FFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLE--FLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNW--PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLAL-VGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSR 530
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|Q6VVW5|ANPRB_MOUSE (Atrial natriuretic peptide receptor 2 OS=Mus musculus OX=10090 GN=Npr2 PE=1 SV=2) HSP 1 Score: 609.372 bits (1570), Expect = 0.000e+0 Identity = 312/551 (56.62%), Postives = 392/551 (71.14%), Query Frame = 2
Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
H+G+ S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RFIG C++P + +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++ HG LKSSNCVVDSRFVLK+TD+GL R S EP SH Y K LWT+PE+L LP G K DVYSFAII QEI R G F ++ D PKEIV+ V++ + FRPS+D + +L+ ++++ W +DP RPDF IK +R+ +K E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HA EIARM L L A+ F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S +T + L F + RG+VEMKGKGK TYWL GE
Sbjct: 508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLS-PKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQ 1040 HSP 2 Score: 151.754 bits (382), Expect = 8.042e-36 Identity = 113/431 (26.22%), Postives = 196/431 (45.48%), Query Frame = 2
Query: 458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLKNYK-TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
+GP + ++AR + + + L++ G F K++ Y+ L R + L F+ L + W R + Y+D ++ ++++ + + E L+ + ++ A + + + R++ ICG + I+L A L ++VF ++D+F T RPW D ++ ++ +++R AF+++L++ + P N EY N L ARE + +N + FY+ I+LYA LN+ + T + RI M R ++G V +D +R +DF L+ + D SG+FQ Y+G+ E G+ I W K PPLD P CAFD C K ST I T F++ + F +R+L + EL +M W I WE L ++ + SR
Sbjct: 96 LLGPGCVYPAASVARFA-SHWRLPLLTAGAVASGFAAKNE-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSR 514
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16067|ANPRB_RAT (Atrial natriuretic peptide receptor 2 OS=Rattus norvegicus OX=10116 GN=Npr2 PE=1 SV=1) HSP 1 Score: 608.986 bits (1569), Expect = 0.000e+0 Identity = 312/550 (56.73%), Postives = 392/550 (71.27%), Query Frame = 2
Query: 1886 HRGSAS-------NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEP--SHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESG-NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
H+G+ S SY SL+T G Q+F T FKGN+VA+K +N ++ E T+++L ++K ++D+ +H+ RFIG C++P + +V EYCP+GSL+D+LEN+ INLDWMFR SLI D+V+GM +LH++ HG LKSSNCVVDSRFVLK+TD+GL R S EP SH Y K LWT+PE+L LP G K DVYSFAII QEI R G F ++ D PKEIV+ V++ + FRPS+D + +L+ ++++ W +DP RPDF IK +R+ +K E G +ILDNLL RMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HA EIARM L L A+ F I HRP+ QL LRIGVH+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S +T + L F + RG+VEMKGKGK TYWL GE
Sbjct: 508 HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHVNK-KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR------STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNK--EGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039 HSP 2 Score: 150.599 bits (379), Expect = 2.018e-35 Identity = 113/434 (26.04%), Postives = 200/434 (46.08%), Query Frame = 2
Query: 458 FIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYS-DYFYSAKEMMERLK----NYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--------TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFD--GSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
+GP + ++AR + + ++ L++ G F K++ Y+ L R + L F+ L + W R + Y+D ++ ++++ + + E L+ + + + Y + ++ + + R++ ICG + I+L A L ++VF ++D+F T RPW D ++ ++ +++R AF+++L++ + P N EY N L ARE + +N + FY+ I+LYA LN+ + T + RI M R ++G V +D +R +DF L+ + D +SG+FQ Y+G+ E G+ I W K PPLD P CAFD C K ST I T F++ + F +R+L + EL +M W I WE L ++ + SR
Sbjct: 96 LLGPGCVYPAASVARFA-SHWHLPLLTAGAVASGFAAKNE-HYRTLVRTGPSAPKLGEFVVTLHGHFNWTAR----AALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYTREPGGPEQ---ATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQA-QALREAFQTVLVITYREPPNPEY--QEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGA-EKQIWWTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSR 514
BLAST of Guanylate cyclase vs. TrEMBL
Match: G4V651 (Guanylate cyclase OS=Schistosoma mansoni OX=6183 GN=Smp_142620 PE=3 SV=1) HSP 1 Score: 964.526 bits (2492), Expect = 0.000e+0 Identity = 506/1053 (48.05%), Postives = 672/1053 (63.82%), Query Frame = 2
Query: 449 VHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTE------GYKADASSLKE---IREK-LKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNP--RPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDG-TSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRT--QTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKII 3547
V+ GP + +L AR S +N +V+ AG+ + DK++Y LTR+ + L G LK Y WLP I + + + M ++ + YK + +L + + ++ LK L +R+II+C + R IML A ++ + ++ F ++DL + RPW+ + SS E NE R A+R+++ V L P + EY + ++R A Y+FSY E+ +F++++ LYALALND AK T+ IT MWNRTF G V+IDA G+R +D+SL D++P +G+F+ V Y G+ ++ S + G++I+W N N+PPL TP C FDGS C G++ L + ++ G YRR KFQAEL+AMNWIIPW++L EK R R++S + SPN SD P+ I + +A+N +Q+F +TA + +IVALK + + E +K + +++KK+KDLN DHICR IG+C+E HQ +VYEYCPKGSL+D+LENEQI LDWMF+ SL+QDI RG++YLH +G HG+LKSSNC+VDSRFVLK+TDFGL +R S E S +++ +LWT+PE+L T+ ++KGDVYSFAI+ QEI+YR+GVF + N + +P IV+ VK+ + PFRP+LD ++GCS DL+++I QAWD+DP+ RPDF IK SMRK++K +S N+LDNLLSRMEQYANNLE LV QRT +YLEEKK+ EDLLYSMLP+SVA QL +NQ V+AES+E VTIYFSDIVGFTSLSA+STPMQV+ELLNRLYT FD IIENFD YKVETIGDAYMV SGLP NG HARE+ARM + FL AIF F IPHRP +LELRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNGLPLKIHIS T +VLK+F++FIM+ERG VEMKGKG+Q TYWLHGE+ +IVDP+P A+I+
Sbjct: 145 VNVIFGPLNDFTLANAARFSTAMYNVPIVA--PAGFAHQLSDKLEYGMLTRVLFTYSDLEWVFGNTLKHYGWLPDQQTPIAIVTTRNVRRREGVVGHTGMAGVFQHLILQKFLVKAAYKLLSVTLDDEFDVTDRFLKRLPDSARIIILCTDPEVVRDIMLEAHKLNMVNGDYAFFNMDLLSSQTKLKRPWYRETSSPEENERARQAYRALMTVTLLKPDSPEY--RTFTEEVRARALRDYDFSYRDSEVTPFIGTFHDAVKLYALALNDALAKGGTITNGTLITQEMWNRTFKGVTGVVRIDANGDRNADYSLLDMNPVTGDFEVVVNYFGNDKSLSTVLGRTIDWINTDNQPPLHTPPCGFDGSECHNSHFIHIGIVGAVVFILLMTMSLVLGIIFYRRAKFQAELRAMNWIIPWDALQVTEKHLRRY----RRESDIR---------------------------------------SPNQSSD--PLRKISSETCTAAAAN-------------------SQMFARTAFYMKSIVALKPLRRQTRMEPSKALSIEVKKVKDLNCDHICRLIGVCLEVPHQCIVYEYCPKGSLQDVLENEQIKLDWMFKFSLMQDICRGVMYLHQIFGPHGNLKSSNCLVDSRFVLKITDFGLPHIRGPPPLES-EVGSFIFHRNLLWTAPELLPDGDTTIYPRESIKGDVYSFAIVCQEIVYRKGVFYIQNFKNCEPDFIVKEVKAHRKPPFRPTLDSLEGCSEDLVQLICQAWDDDPSVRPDFQSIKLSMRKLNKAGDSNNVLDNLLSRMEQYANNLEELVEQRTAQYLEEKKKTEDLLYSMLPRSVAKQLFRNQPVTAESFEMVTIYFSDIVGFTSLSAESTPMQVVELLNRLYTLFDGIIENFDAYKVETIGDAYMVASGLPQRNGNKHAREVARMSIAFLKAIFEFQIPHRPEKRLELRIGIHSGPVCAGVVGQKMPRYCLFGDTVNTSSRMESNGLPLKIHISQQTFDVLKTFKSFIMTERGLVEMKGKGRQKTYWLHGEDCYIVDPIPPGAQIV 1128
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8JDN4 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 892.493 bits (2305), Expect = 0.000e+0 Identity = 484/1071 (45.19%), Postives = 669/1071 (62.46%), Query Frame = 2
Query: 464 GPNSIISLGTIARMSGTR-FNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK---------------------SYSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYA-------KNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTG-------LIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPN--SDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKIN-TGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRT-QTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKS--SKHVPFRPSLDE----IDGCS-SDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDP 3523
GP L +AR + + + +++ G A +DK +Y L R+ + + N + + + Y WLPR +N+ + Y+ D + + F + R+K Y + + +RE++ R++++C R IM+ A E+ E+VF +IDLF+ L RPW+ + S+E N + A+R+++ + L P ++EY + S + ++ A++ Y+F YP+EE+N +F+++++LYALA+ND A N +L IT+ M +RTF G V I+A G+R +D+SL D+D + NF V Y G+T+ Y L+ GK I+W ++ N PP D PKC FD S CKKD + L+ C + L IGVI YR+L+ ++EL AMNW I W L+ E+ R+ ++ + S + E + + + GN+Q E E L +PN D DP +A +GS S S+ TI+GV L I Q+F KTA +KGN+VALK+I ++ E ++L++IK++KDL +D+I RFIG C++ ++ LV EYCPKGSL+D+LEN+ +NLDWMF+ SL+ DI RGMIYLH ++G HG+LKSSNC+VDSRF LK+ DFGL+ LR ++ ++ + Y+ LWT+PE+LR T P GT +GDVYSF IIAQEIIYR+GVF + + D +P++I+E ++ PFRPSL + +DG L+ I++ W EDPN RP+F +K+ + + +K ESGNILDNLL RMEQY+NNLE LVA+RT +YLEEKK+AE+LLY MLPK VA L+K +SV+AE ++ VTIYFSDI GFT+LS++STPM+V+ LLN LYT FD IIE +D YKVETIGDAYMVVSGLP NG HAREIARM L FL IF F I H+P+ QL+LRIGVHSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIHIS T +L+ F+ +ERGEVEMKGKG Q TYWLHGEND IVDP
Sbjct: 37 GPFCTFCLAAVARYNRYYLYQKPIITSGAAA---NLEDKEEYYNLIRVGPMNFDIENMLLAIFQRYNWLPRQQQNLLIIYVPDDETQLHKQRDETRVTFSRLLRTTIENRFSHQHRYILRVKPYSATNKHFQSEVFRCMREEV-------RLVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFS--DKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSL--ITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVL--IGVI-----YRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTF------GNHQQEGE----EAQPLNPTPNEQQQQDEDPAIA-----PKGSDVVSSNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKELKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEPQDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1071
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8HCY1 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 884.404 bits (2284), Expect = 0.000e+0 Identity = 480/1083 (44.32%), Postives = 673/1083 (62.14%), Query Frame = 2
Query: 431 FILDEPVHAFIGPNSIISLGTIARMSGT-RFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSD---------------------YFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAK-------NDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDP---MVAIRNGKHRGSASNE-SYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKIN-TGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLD----EIDGCSSD-LIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKIIQ 3550
+L + + +GP +L +AR + + R +++ G G +DK +Y L R+ + + + + + + + W PR + I + D+ + +F K ++ RL+ Y+ + + + +R+++ R++++C R IM+ A E+ E+VF +IDLF+ L +PW + + E NE A+R+++ + L P + EY N S ++ IA+ KYNF+YP+EE+N +F+++++LYALA+ND + N +L IT M NRTF G V I+A G+R +D+SL D+D + NF V Y G+ + Y L+ GK I+W NE N PP D PKC FD S+CK+D + L + + YR+L+ ++EL AMNW IPW L+ +E+ R+ S + L D++ ++ + Q +++ + L NS N S +N +H G+A+ E S +S+ TI+GV L I TQ+F KTA +KG +VALK ++ ++ E T ++L+++K++KDL +D++ RFIG C++ ++ LV EYCPKGSL+D+LEN+ +NLDWMF+ SL+ DI RGMIYLH N+G HG+LKSSNC+VDSRF LK+ DFGL LR + E+ + Y+ LWT+PE+LR T P GT +GDVYSFAII QEIIYRRGVF + + D +P+EIVE VK + +RP+LD + D S+ LI ++ W EDP RP F IK+ + + +K ESGNILDNLL RMEQY+NNLE LVA+RT YLEEKK+AE+LLY MLPKSVA L++ +SV+AE ++ VTIYFSDI GFT+LS++STP++V+ LLN LYT FD IIE +D YKVETIGDAYMVVSGLP NG HAREI+RM L FL I+ F I H+P+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIHIS T E+L+ F+ + RGEVEMKGKGKQLTYWLHGE D IVDPV + + Q
Sbjct: 48 LLLQQKIDLMLGPYCSFALAAVARYNRMPHYRRPILTTG--GVASALRDKAEYFNLIRVGPSFDGVEKMLYLVFQRFNWKPRDVQTILFIELPDEDVKEKRTRDEIGVTQSRILCHGIEKHFVQEKYIVRRLQ-YEMHNAQFKSEIFRVMRDEI-------RLVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFS--QQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSL--ITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMER-----IAAGRRTSESGKDLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVKEISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPVVSNGSLNQ 1111
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8GAT2 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 877.47 bits (2266), Expect = 0.000e+0 Identity = 492/1150 (42.78%), Postives = 698/1150 (60.70%), Query Frame = 2
Query: 230 LEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTR-FNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEM---------MERLKNYKTEGYKADASSLKEIREKL-----KLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLY-------AKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR-------KDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMET------TLLLNSPNSDSDIDPMVAIRNGKHRG--SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKIN-TGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKE-NSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSL-DEIDGCSSD----LIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPES 3535
+ ++N ++M +E ++ P+ D+A+A + + +N +++L ++S +I +L E V +GP LG +AR + + R +++ G G +KV+Y L R+ +HE + + K+ K Y W PRP + + V D+ S S + +E++ Y A + K R L K+L + R++++C R IM+ A E+ E+VF +IDLF+ L RPW + E N A+RS++ + L P + EY N S ++++A KYNF+YP+EE+N +F+++++LYALA+ND +N +L +T M +R+F G V I+ G+R +D+SL D+D +G F V YNG+ + Y L++ + I+W NE+N PP D P C FD SLCKKD T L L I F YR+L+ ++EL MNW I WE L+ E+ R+ +++ K +T + ++K ++ Q N+ G+K + TL L ++ I G + + S S+ TI+GV L I Q+F KTA +KG +VALK++N ++ E T +L+++K++KDL +D++ RFIG C++P ++ LV EYCPKGSL+D+LEN+ +NLDWMF+LSL+ DI RGMIYLH ++G HG+LKSSNC+VDSRF LK+ DFGL LR + E E+ + Y+ LWT+PE+LR PF GT +GDVYSFAII QE+IYR+GVF + + D +P++IVE V++ ++ PFRP+L +E+ D L +++ W EDP RP F K+ + + +K ESGNILDNLL RMEQY+NNLE LVA+RT +Y EKK+AEDLLY MLPK+VA L++ ++V+AE ++ V+IYFSDI GFT+LS++STP+QV+ LLN LYT FD IIE + YKVETIGDAYMVVSGLP NG HA EI+RM L FL+ I+ F I H P QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIHIS +T E+L F+ + RGEVEMKGKGKQLTYWLHGE D IVDP P +
Sbjct: 1 MSRHNISHMSLE---RVLPVVDVAVASAQSVGL------LSNVTVRLLSNDSEC---DYSIAPVVGMLMLRE-VDLMLGPYCSFCLGAVARYNRYHLYQRPIITSG--GGASVLNNKVEYYNLIRVGPSHEQIEEMLLKIFKHYNWRPRPVQTVLVVGPPDEINSRQHQSESIISDALVMSVAIEKMLTQPNVSYIARRLTYKPGRPHLATQLFKVLEEV-RIVVLCADPDTVRDIMIRAEELGFINGEYVFFNIDLFSSEKLTVRPWRRVNDTAERNSKAFRAYRSLMTITLRKPNSPEYRNFS--RQVKELAYHKYNFTYPEEEVNSFVGAFHDAVLLYALAINDTLREHGSEGIRNGSL--VTEKMKSRSFEGITGTVSINKNGDRNADYSLLDMDKDTGEFAVVAHYNGNKKVYELVKDRQIDWNNEENLPPKDIPTCGFDYSLCKKDLTQMALYAVVVLLVLICFLTILIFVIYRKLRLESELHGMNWRIAWEELEPTERVAARRRSLAQPQPPPPQKQTTNKKKRARLNQKKQQQQQPHWFFANHHGTKRSNRGDPDEAAAETLPLRPSGGGANDSGGGDIGAGDSQSVVQMDSASMESVETIAGVPLSQIPTAQLFAKTAYYKGTLVALKQLNLRNKRIEVTNRLLMEVKRVKDLASDNVVRFIGACLDPPNECLVTEYCPKGSLQDILENDNLNLDWMFKLSLMADICRGMIYLHHSFGSHGNLKSSNCMVDSRFSLKIADFGLQSLRSNKLEYRDKEDGDYSTYRNKLWTAPELLRLPNPPFEGTKEGDVYSFAIICQEVIYRKGVFFLSDSDFIEPQDIVERVRTPQNPPFRPALVEEMSDLEPDRTAALTAMVELCWHEDPGARPTFNAAKSRISRFNKTAESGNILDNLLKRMEQYSNNLESLVAKRTDQYQVEKKKAEDLLYCMLPKAVATTLMRGEAVTAEWFDSVSIYFSDICGFTALSSESTPLQVVTLLNDLYTLFDRIIEQYSCYKVETIGDAYMVVSGLPERNGNRHAGEISRMALSFLNNIYSFEIRHMPGVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISATTHELLTDIGNFVTTVRGEVEMKGKGKQLTYWLHGEGDKIVDPPPAA 1130
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A267FJR9 (Guanylate cyclase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025214g3 PE=3 SV=1) HSP 1 Score: 872.848 bits (2254), Expect = 0.000e+0 Identity = 464/946 (49.05%), Postives = 626/946 (66.17%), Query Frame = 2
Query: 776 EGYKADASSLKEIREKL-KLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYA-------KNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTG-------LIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPN--SDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKIN-TGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRT-QTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKS--SKHVPFRPSLDE----IDGCS-SDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDP 3523
EG + D+S+ R L + +S+ V+++C R IM+ A E+ E+VF +IDLF+ L RPW+ + S+E N + A+R+++ + L P ++EY + S + ++ A++ Y+F YP+EE+N +F+++++LYALA+ND A N +L IT+ M +RTF G V I+A G+R +D+SL D+D + NF V Y G+T+ Y L+ GK I+W ++ N PP D PKC FD S CKKD + L+ C + L IGVI YR+L+ ++EL AMNW I W L+ E+ R+ ++ + S + E + + + GN+Q E E L +PN D DP +A +GS S S+ TI+GV L I Q+F KTA +KGN+VALK+I ++ E ++L++IK++KDL +D+I RFIG C++ ++ LV EYCPKGSL+D+LEN+ +NLDWMF+ SL+ DI RGMIYLH ++G HG+LKSSNC+VDSRF LK+ DFGL+ LR ++ ++ + Y+ LWT+PE+LR T P GT +GDVYSF IIAQEIIYR+GVF + + D +P++I+E ++ PFRPSL + +DG L+ I++ W EDPN RP+F +K+ + + +K ESGNILDNLL RMEQY+NNLE LVA+RT +YLEEKK+AE+LLY MLPK VA L+K +SV+AE ++ VTIYFSDI GFT+LS++STPM+V+ LLN LYT FD IIE +D YKVETIGDAYMVVSGLP NG HAREIARM L FL IF F I H+P+ QL+LRIGVHSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIHIS T +L+ F+ +ERGEVEMKGKG Q TYWLHGEND IVDP
Sbjct: 244 EGRQNDSSTSSLYRRILHERVSTKFSVVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFS--DKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSL--ITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVL--IGVI-----YRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTF------GNHQQEGE----EAQPLNPTPNEQQQQDEDPAIA-----PKGSDVVSSNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKELKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEPQDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1163
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 625.165 bits (1611), Expect = 0.000e+0 Identity = 317/540 (58.70%), Postives = 403/540 (74.63%), Query Frame = 2
Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
RGS +Y SL+T G N QVF KTA FKGNIVA+K +N ++ E T+++L ++K ++D+ NDH+ RFIG C++P + +V EYCP+GSL+D+LENE I LDWMF+ SLI DIV+GM +LH S HG+LKSSNCVVD+RFVLK+TD+GL+ R S+ E +H YY + LW +P++LR P GT KGD+YSF II QE+ RRGVF ++ DS PKEIV+ V + RP+++ S +L +++++ W E+P RP+F IK +RK ++ + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HAREIARM L L A+ F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ ++L+ F F + RG+VEMKGKGK TYWL GE+
Sbjct: 548 RGS----NYGSLLTADG-------NFQVFAKTAYFKGNIVAIKYVNR-KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT----ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNR-EVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGES 1068 HSP 2 Score: 142.51 bits (358), Expect = 6.725e-34 Identity = 108/414 (26.09%), Postives = 186/414 (44.93%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK-SYSDYFYSAKEMMERLKNYKTEG----YKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKND---TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
AFIGP + + + T + +++ G F + Y +T H+ L F + + + W ++ + + D K + +++ + + LK ++ D+ + E L+ + RV+ +C + R +M+ + L EFVFI+ID+F T +PW + DE+ + + + +L + P N EY + + DL+ A++ +NF+ +N ++ FY+ +MLY ALN+ A++ + IT MWNRT+ G V+ID G+R +DF+L+D+ D S FQ V YNG+ + + G + W P D P C F D C + + + VI F YR+LK + EL A W I WE +
Sbjct: 126 AFIGPGCDYTSSPVGLFT-THWGLPMITAGAPAVGFSDRSDA-YTSITNTGPTHKKLGEFALHICRHFGW----SQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVN-YSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVK-ILTYREPQNPEYKDFVM--DLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDM 527
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 625.165 bits (1611), Expect = 0.000e+0 Identity = 317/540 (58.70%), Postives = 403/540 (74.63%), Query Frame = 2
Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
RGS +Y SL+T G N QVF KTA FKGNIVA+K +N ++ E T+++L ++K ++D+ NDH+ RFIG C++P + +V EYCP+GSL+D+LENE I LDWMF+ SLI DIV+GM +LH S HG+LKSSNCVVD+RFVLK+TD+GL+ R S+ E +H YY + LW +P++LR P GT KGD+YSF II QE+ RRGVF ++ DS PKEIV+ V + RP+++ S +L +++++ W E+P RP+F IK +RK ++ + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HAREIARM L L A+ F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ ++L+ F F + RG+VEMKGKGK TYWL GE+
Sbjct: 548 RGS----NYGSLLTADG-------NFQVFAKTAYFKGNIVAIKYVNR-KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT----ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNR-EVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGES 1068 HSP 2 Score: 142.51 bits (358), Expect = 6.725e-34 Identity = 108/414 (26.09%), Postives = 186/414 (44.93%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK-SYSDYFYSAKEMMERLKNYKTEG----YKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKND---TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
AFIGP + + + T + +++ G F + Y +T H+ L F + + + W ++ + + D K + +++ + + LK ++ D+ + E L+ + RV+ +C + R +M+ + L EFVFI+ID+F T +PW + DE+ + + + +L + P N EY + + DL+ A++ +NF+ +N ++ FY+ +MLY ALN+ A++ + IT MWNRT+ G V+ID G+R +DF+L+D+ D S FQ V YNG+ + + G + W P D P C F D C + + + VI F YR+LK + EL A W I WE +
Sbjct: 126 AFIGPGCDYTSSPVGLFT-THWGLPMITAGAPAVGFSDRSDA-YTSITNTGPTHKKLGEFALHICRHFGW----SQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVN-YSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVK-ILTYREPQNPEYKDFVM--DLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDM 527
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 591.652 bits (1524), Expect = 0.000e+0 Identity = 305/549 (55.56%), Postives = 393/549 (71.58%), Query Frame = 2
Query: 1868 AIRNGKHRGSAS--NESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
A+R R + S +Y SL+T+ G N Q++ KT +KGNI A+K +N ++ E T+++L ++K ++D+ N+H+ RFIG C++ + ++ EYCP+GSL+DL+E E I LDWMFR SLI DIV+GM +LH S HG+LKSSNC+VDSRFVLK+TD+GL R+ S E +H YY + LWT+PE++R + GT KGDVYSF II QE+ +GVF +D+ PKEIVE V + RP L S +L +++++ W ED N RPDF IK + K ++G S NILDNLLSRMEQYANNLE LV +RTQ Y EEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT++SA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H EIARM L L A++ F I HRP+ QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S +T VL+ F F + RG++EMKGKG+ TYWL GE+
Sbjct: 515 ALRRACSRLTLSLRGSNYGSLLTLEG-------NVQIYAKTCYYKGNITAIKYVNK-KRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFRK----ESYLEDTHAYYARKLWTAPELMRDENRQPCGTQKGDVYSFGIILQELALLKGVFYLDS-PPFSPKEIVEHVAEGRWPYLRPLLC-TQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHKNNRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDIEMKGKGRMRTYWLLGES 1048 HSP 2 Score: 103.219 bits (256), Expect = 9.116e-22 Identity = 107/419 (25.54%), Postives = 182/419 (43.44%), Query Frame = 2
Query: 173 GKKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSES--------STVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSA-----KEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF-TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALN---DLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQ 1369
G+ P +A+++ N E ++GP + AL EK+ L Y ++L FS S +V+ + +F + +P AFIGP + +AR + T + +V+ G F Y +T H+ L F+ ++ + W HK V + D K+ Y A EM K + D L + + +S RV+ +C R +M+ + +L E+VF IDLF L RP D +E+ + AF+S+ I+ + P N EY + +++ A++++NFS +N + F++ ++LY+ ALN D +T MWNRTF+G V++D G+R DF+L+D+ D +SG ++
Sbjct: 17 GRTSVPPNITLAIILPKQNTEYPWA-------WPRVGPALNWAL---EKVNSDPTL--LPGYHMQLVFSSSENKEGLCSDSVAPLVAVDLKFAH----DP-WAFIGPGCDYASSPVARFT-THWEVPMVTAGAPALGFNM-----YSSITNTGPTHKKLGEFVVRMHHNFGW----HKYAMVMFHDKKNDDRPCYFAVEGPYTEMTADNITAKDMVFNEDDEPLS-YADLINGISQRGRVVYVCCKWDTFRKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPWARGDADDEAAKQAFKSVKIMTYREPQNPEY--KHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYE 405
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 576.244 bits (1484), Expect = 0.000e+0 Identity = 300/540 (55.56%), Postives = 384/540 (71.11%), Query Frame = 2
Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
RGS +Y SL+T G N QVF KTA FKGNIVA+K +N ++ E T+++L ++K ++D+ NDH+ RFIG C++P + +V EYCP+GSL ++ GM +LH S HG+LKSSNCVVD+RFVLK+TD+GL+ R S+ E +H YY + LW +P++LR P GT KGD+YSF II QE+ RRGVF ++ DS PKEIV+ V + RP+++ S +L +++++ W E+P RP+F IK +RK ++ + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HAREIARM L L A+ F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ ++L+ F F + RG+VEMKGKGK TYWL GE+
Sbjct: 528 RGS----NYGSLLTADG-------NFQVFAKTAYFKGNIVAIKYVNR-KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSL----------------------VLSGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT----ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNR-EVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGES 1026 HSP 2 Score: 142.124 bits (357), Expect = 8.557e-34 Identity = 108/414 (26.09%), Postives = 186/414 (44.93%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK-SYSDYFYSAKEMMERLKNYKTEG----YKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKND---TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
AFIGP + + + T + +++ G F + Y +T H+ L F + + + W ++ + + D K + +++ + + LK ++ D+ + E L+ + RV+ +C + R +M+ + L EFVFI+ID+F T +PW + DE+ + + + +L + P N EY + + DL+ A++ +NF+ +N ++ FY+ +MLY ALN+ A++ + IT MWNRT+ G V+ID G+R +DF+L+D+ D S FQ V YNG+ + + G + W P D P C F D C + + + VI F YR+LK + EL A W I WE +
Sbjct: 106 AFIGPGCDYTSSPVGLFT-THWGLPMITAGAPAVGFSDRSDA-YTSITNTGPTHKKLGEFALHICRHFGW----SQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVN-YSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVK-ILTYREPQNPEYKDFVM--DLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPGGFIPP--DMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDM 507
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 576.244 bits (1484), Expect = 0.000e+0 Identity = 300/540 (55.56%), Postives = 383/540 (70.93%), Query Frame = 2
Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
RGS +Y SL+T G N QVF KTA FKGNIVA+K +N ++ E T+++L ++K ++D+ NDH+ RFIG C++P + +V EYCP+GSL+D+LENE I LDWMF+ SLI DIV+GM +LH S HG+LKSSNCVVD+RFVLK+TD+GL+ R S+ E +H YY + LW +P++LR P GT KGD+YSF II QE+ RRGVF ++ DS PKEIV+ V + RP+++ S +L +++++ W E+P RP+F IK +RK ++ + S +ILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV ETIGDAYMVVSGLP NG+ HAREIARM L L A+ F I HRP+ QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ ++L+ F F + RG+VEMKGKGK TYWL GE+
Sbjct: 567 RGS----NYGSLLTADG-------NFQVFAKTAYFKGNIVAIKYVNR-KRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRT----ESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNR-EVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQV-----------------------ETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGES 1064 HSP 2 Score: 142.51 bits (358), Expect = 7.103e-34 Identity = 108/414 (26.09%), Postives = 186/414 (44.93%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDK-SYSDYFYSAKEMMERLKNYKTEG----YKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF----TGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKND---TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
AFIGP + + + T + +++ G F + Y +T H+ L F + + + W ++ + + D K + +++ + + LK ++ D+ + E L+ + RV+ +C + R +M+ + L EFVFI+ID+F T +PW + DE+ + + + +L + P N EY + + DL+ A++ +NF+ +N ++ FY+ +MLY ALN+ A++ + IT MWNRT+ G V+ID G+R +DF+L+D+ D S FQ V YNG+ + + G + W P D P C F D C + + + VI F YR+LK + EL A W I WE +
Sbjct: 145 AFIGPGCDYTSSPVGLFT-THWGLPMITAGAPAVGFSDRSDA-YTSITNTGPTHKKLGEFALHICRHFGW----SQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTVDLVFEEDSRPVN-YSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVK-ILTYREPQNPEYKDFVM--DLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPGGFIPP--DMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDM 546
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006352.1 (pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 gene:ENSPMAG00000005587.1 transcript:ENSPMAT00000006352.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 607.831 bits (1566), Expect = 0.000e+0 Identity = 318/544 (58.46%), Postives = 394/544 (72.43%), Query Frame = 2
Query: 1883 KHRGSASNESYMSLVTISGVQLENIQN-TQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLE-DLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCS-SDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
K R SA ++ +S+ S L Q Q+F KT ++GN+VA+K IN +K E T+E+L ++K ++D+ N+H+ RF+G C++P + +V EYCP+GSL+ D+LENE I LDW+FR SLI DIV+GM++LH S G HG LKSSNCVVDSRFVLK+TD+GL R S E H Y K LWT+PE+LR + P GT KGDVYS II QEI R G F V+ D PKEIV+ VK+ + FRPS DE C +L ++++ W EDP RPDF IK + K +K + S NILDNLLSRMEQYANNLE LV +RTQ YLEEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTSLSA+STPMQV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ +A+EIARM L L A+ F I HR +L+LRIG+H+GPVCAGVVG KMPR+CLFGDTVNT+SRMESNG LKIH+S +T EVL F F + RG+VEMKGKGK TYWL GE
Sbjct: 286 KARRSAGSKLTLSMRGSSCGSLLTTQGRNQMFAKTGYYRGNLVAIKPINK-KKIELTREVLFELKHMRDVLNEHLTRFVGACIDPPNICIVTEYCPRGSLQQDILENESITLDWVFRYSLINDIVKGMLFLHNSVIGSHGSLKSSNCVVDSRFVLKITDYGLASFRSC----SECEDMHSLYAKKLWTAPELLRLEHPPPQGTQKGDVYSLGIILQEIALRNGTFYVEGMD-LSPKEIVQKVKNGQRPYFRPSTDE--SCHIEELGLLMQRCWAEDPAERPDFSQIKMLIHKFNK-ENSTNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAETLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLNAKEIARMSLALLDAVKTFKIRHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWLLGE 820 HSP 2 Score: 148.673 bits (374), Expect = 1.106e-36 Identity = 99/348 (28.45%), Postives = 170/348 (48.85%), Query Frame = 2
Query: 851 VIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT--------GLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLD---RITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQG--------SKEKIEMETTLLL 1828
V+ C ++ R M+ A + ++VF ++D F+ + +PW K DE +E + A+++++I+ + P N EY + + L+K A+E++NF+ +N + SFY++IM+Y ALN + + IT +MWNRT+ G ID G+R +DFSL+DL D +G F V Y+G++ + G I+W P D P C F+ C G ST + + + +I + F YR+LK + EL +M W + WE++ K R+S S+ ++ + ++Q K+G Y+G +K+KIE+ +L
Sbjct: 6 VVYFCCSAAVFRQTMVQAHAEGMTAGDYVFFYVDPFSESLSESNVSESRKPW---KRGDEFDEQAKEAYKAVMIISYREPQNIEYKDFVV--KLKKRAKEQFNFTIEDTLMNLIAGSFYDAIMMYTAALNKTLSSGGGVHDGHAITKHMWNRTYRGVTGEFTIDRNGDRETDFSLWDLTDMNTGEFNVVLSYDGASSKLIEVPGLEIQWPG--GSIPKDVPLCGFENEACISGGFSTMEVLMIVFSLILLIVAVSSFLIYRKLKLEKELASMLWRLRWENIQVSSLEKARRSAGSKLTLSMRGSSCGSLLTTQGRNQMFAKTGYYRGNLVAIKPINKKKIELTREVLF 346
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943]) HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0 Identity = 287/511 (56.16%), Postives = 372/511 (72.80%), Query Frame = 2
Query: 1994 KGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKI---DKGKESG---NILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
+GN+V + IN +K E T++ML ++K ++D+ N+H+ RF+G C++ + ++ EYCP+GSL+D+LENE I+LDWMFR SL+ DIV+GM+YLHS+ G HG+LKSSNCVVDSRFVLK+TD+GL+ +R K +S S Y++K LWT+PE+LR + + GT KGDVYSFAII QEI R G F ++ + KEIV+ VK + RP++D G S +L ++++ W E+ RPDF IK ++K D G ES ILDNLLSRMEQYANNLE LV +RTQ YLEEK +AE LLY +LP SVA QL + ++V AE+++ VTIY SDIVGFT++SA STPMQV+ LN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG HA E+ARM L LSA+ F I HRP +L LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRME+ G +IH+S +T +L + F++ G+V++KGKG TYWL GEN
Sbjct: 1 QGNLVEIPFINR-KKIELTRQMLFELKHMRDVQNEHLTRFVGACIDVPNICIITEYCPRGSLQDILENESISLDWMFRYSLMHDIVKGMLYLHSSVIGSHGNLKSSNCVVDSRFVLKITDYGLSSVRAHSKADS----SANYFEKRLWTAPELLRLEEVAPRGTQKGDVYSFAIILQEIALRSGPFYLE-ANHLTAKEIVQRVKLGEWPYLRPTVDP-GGHSEELGHLMQRCWAEESTERPDFHQIKILLQKFSSQDDGPESPPAFTILDNLLSRMEQYANNLEELVEERTQAYLEEKGKAEALLYQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVHNGTRHAIEVARMALALLSAVRCFHIRHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLGEN 504
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008976.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008976.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 453.366 bits (1165), Expect = 1.161e-144 Identity = 297/798 (37.22%), Postives = 430/798 (53.88%), Query Frame = 2
Query: 1172 FYESIMLYALALNDLYAKND------TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLI----EGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTS---TGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMN---WIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPS-HEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYR--RGVFAVDNCDSKDPKEIVESVKSSKHV-PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
+++ +LYA+A+ +L + + R F G V ID G R D+++FDL K ++ + T+ I E + + W + + PP D P+C F G LC++ S L+ + +L VIG + F Y ++ ++ ++M+ W I +E + V L+N G+Y+ S +++ N N D+ G+ E + + + V L+ ++ T K N ALK +EML ++++ F G+CVE + +V +YC KGSL+D+L+ LDWMF+ S DIV GMI+LH S HG+LK S C++DSR +KLT FG+ R +K + + + ++ ++ WT+PE+LR + LP GT KGDV+SFAI+ +E+IY G + + +PK+I++ V+ V P RP L E C + +I+Q WDE + RPDF + +R + + NILDN++S++E+YAN+LE +V RT + EKK+ + LL S+LP V QL ++V E YE VTI+F DIVGFT++SA STP++VI LLN LY D II+ +DVYKVETIGDAYMV SGLP NG H EIA M L FLS+I F I H P QL+LRIG++SGPV AGVVG+ MPRYCLFGDTVN +SRMES G PL IH+S +T +LK + + ERG + +KGKG QLTYWL G+
Sbjct: 4 LHDAGILYAMAVRELLRQGGNPRDGRAVIRTIRGSNKIKFYGASGQVSIDVNGERFLDYAVFDLQKKQTATGEMRIASKRYFTFQTINFTPEYQKMGWPDGR--PPSDMPECGFTGELCQEAPISEPDLALVLVGSILSLIVIGTV-AFLTYLVVQSRSLQESMDTTWWKINFEDITLV-------------------PLVN---------------GSYRSSSKQVSG------NQSNVHHDV-----------HGTDRVEIPIGIYQGNQVALKFLERTH----PPDLKSNRFALK----------MREML----------HENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINNLGSFFIELYWTAPELLRMEDLPVNGTPKGDVFSFAILMREVIYHEDEGPYVGIHL---EPKDIIDQVRDGIAVPPLRPLLTE--RCEPRIQALIRQCWDESADRRPDFSSVSRMLR-LASPEGDMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 717
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008942.1 (pep scaffold:Pmarinus_7.0:GL476454:59555:94399:-1 gene:ENSPMAG00000008084.1 transcript:ENSPMAT00000008942.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 446.432 bits (1147), Expect = 4.558e-138 Identity = 245/526 (46.58%), Postives = 345/526 (65.59%), Query Frame = 2
Query: 1967 QVFIKTALFKGNIVALKKINTGRKFE-TTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSK-HVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKID-KGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPE 3532
++F +++GN VALK + R + +K +L +++ +++L ++++ F G+CVE + +V +YC KGSL+D+L+ LD MF+ S DIV GMI+LH S HG+LK S C++DSR +KLT FG+ R K+ + +++ ++ WTSPE+LR + P GT KGDV+SF ++ +E+IY D +PKEI++ V+ K P RP L E C + +I++ WDE P+ RPDF I +R +G S ILDN++S++E+YAN+LE +V RT + EKK+ + LL S+LP V QL ++V E +EQVTI+F DIVGFT++SA S+P++VI LLN LY D II+ +DVYKVETIGDAYMV SGLP NG H EI+ M L FLS+I F I H P QL++RIGV+SG V AGVVG+ MPRYCLFGDTVN +SRMES G PL+IH+S ST +LKS + + ERG +++KGKG QLTYWL+G+ F + P+P+
Sbjct: 543 KMFTPLGIYQGNQVALKFLQRTRPPDLKSKTLLKELQMLRELRHENLVVFFGVCVEMPNICIVTQYCRKGSLKDVLKTSDFELDLMFKTSFAYDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRH-GKKGKIMDVNNQDIAELFWTSPELLRMEIFPVNGTPKGDVFSFGVLMREMIYHEDEGPYVGVD-MEPKEIIDQVREGKCSPPLRPLLTE--RCEPRIQALIQRCWDESPDRRPDFHSIARMLRSASPEGHRS--ILDNMVSKLEKYANHLEEVVEDRTAQLESEKKKTDRLLSSLLPSVVVEQLKAGKTVQPEHFEQVTIFFCDIVGFTAMSAISSPLEVITLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEISIMSLHFLSSIINFRIRHLPKEQLKIRIGVNSGSVVAGVVGNTMPRYCLFGDTVNVASRMESTGYPLRIHVSESTASLLKSIGGYELVERGAIQLKGKGSQLTYWLNGKFGFHM-PLPD 1061 HSP 2 Score: 55.0694 bits (131), Expect = 1.142e-7 Identity = 59/259 (22.78%), Postives = 109/259 (42.08%), Query Frame = 2
Query: 773 TEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKY------NFSYPKEELNYVTTSFYESIMLYALALNDLYAKND------TLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPK--SGNFQQVGFYNGSTETYSLI-EGKSIEWGNEKNEPPLDTPKCAFDGSLCKK 1504
T K D S R+ L +S+ +R++I+ S+ R ++L A + L +F+F+ + F ++ +++ ++ A +++ + Y +S L+++ R N S KE Y +++ +LYA+A+ +L + R F G V ID G R D+++F+L K S F V ++ + S E + + W + PP D P C F G LC++
Sbjct: 190 TARIKYDTSDKVLHRQNLLDISTKARIVILICGSEEAREVLLEAQSLGLATGKFIFLVVQQFED----SFWKSVAAERLDTQTLQALEPVMLFTI---KAYGSSDYELFLQEVRRRLLGPPFYSNLSSDKEVSPY-AAYLHDAAILYAMAVRELLRHGGNPRDGRAIVRTIKGSTKVKFYGVSGQVNIDVNGERFLDYAVFNLQKKGNSSQFLPVMVFDTFQGSISFTPEYQKMVW--PEGGPPNDMPICGFLGELCQE 438
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008986.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:128493:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008986.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 430.639 bits (1106), Expect = 2.496e-137 Identity = 235/490 (47.96%), Postives = 314/490 (64.08%), Query Frame = 2
Query: 2054 EMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKE-----NSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVP-FRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
E+ + I +++++ ++++ F G+CVE + +V +YC KGSL+D+L+ LDWMF+ S DIV GMI+LH S HG+LK S C++DSR +KLT FG+ R +K N E+ K++ WT+PE+LR + LP GT KGDV+SFAI+ +E R A P +I++ V+ VP RP L E C + +I+Q WDE + RPDF + +R NILDN++S++E+YAN+LE +V RT + EKK+ + LL S+LP V QL ++V E YE VTI+F DIVGFT++SA STP++VI LLN LY D II+ +DVYKVETIGDAYMV SGLP NG H EIA M L FLS+I F I H P QL+LRIG++SGPV AGVVG+ MPRYCLFGDTVN +SRMES G PL IH+S +T +LK + + ERG + +KGKG QLTYWL G+
Sbjct: 142 EIPIGIYQMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINKQEDAWALSSKELYWTAPELLRMEDLPVNGTPKGDVFSFAILMRESTPREWPTATRANRVPFP-DIIDQVRDGIAVPPLRPLLTE--RCEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGLHMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 628
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086]) HSP 1 Score: 68.9366 bits (167), Expect = 3.806e-12 Identity = 46/167 (27.54%), Postives = 82/167 (49.10%), Query Frame = 2
Query: 2033 RKFETTKEMLLDIKKIKD------LNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAII 2515
R+ KE+ D + +++ L + HICR MC H Y+++EY G L D + + +L + I + YLH+N H LK N ++ S +K+ DFGL+ + + +K+ H + + + +PE+L+ Q P+ G + D++SF I+
Sbjct: 156 RQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYII-QHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQ------LHTFCGSLYFAAPELLKAQ--PYTGP-EVDIWSFGIV 312
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529]) HSP 1 Score: 67.0106 bits (162), Expect = 1.392e-11 Identity = 46/168 (27.38%), Postives = 85/168 (50.60%), Query Frame = 2
Query: 2033 RKFETTKEMLLDIKKIKD------LNNDHICRFIGMCVEPLHQYLVYEYCPKGSLED-LLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAII 2515
R+ + KE+ D + I++ L + HICR MC H Y+++EY G L D ++++ I + + + I +IYLH+N H LK N ++ +K+ DFGL+ + + +K+ H + + + +PE+L+ P+ G + DV+SF ++
Sbjct: 177 RQKKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFA--RGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQ------LHTFCGSLYFAAPELLKAN--PYTGP-EVDVWSFGVV 333
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 63.5438 bits (153), Expect = 1.107e-10 Identity = 45/178 (25.28%), Postives = 89/178 (50.00%), Query Frame = 2
Query: 2003 IVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLS-LIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLN-ILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEII 2530
IVA+K +N E + + +I + +L + I +I +E + ++V EYC GS DLL+ +N ++S +I ++ G+ YLH H +K++N +++ ++KL DFG++ +R K ++ + W +PE++ + + K D++S I E++
Sbjct: 43 IVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKRDT-------FVGTPYWMAPEVVCCEVDGY--NEKADIWSLGITTYELL 211
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354]) HSP 1 Score: 61.6178 bits (148), Expect = 5.521e-10 Identity = 41/161 (25.47%), Postives = 76/161 (47.20%), Query Frame = 2
Query: 2078 IKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVR----GMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVF 2548
+K+L++++I + G E + + EY P GS+ +L N F SLI + R G+ YLH H +K +N ++D + +K+TDFG++ +++ N + + W SPE+++ T K D++S + E+ + F
Sbjct: 508 LKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNY-----GPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGIS--KKLSPLNKKQNKRASLQGSVFWMSPEVVKQTAT----TAKADIWSTGCVVIEMFTGKHPF 657
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 58.151 bits (139), Expect = 7.129e-9 Identity = 39/124 (31.45%), Postives = 64/124 (51.61%), Query Frame = 2
Query: 1988 LFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGL 2359
+F VA I + + T K++L +I+ K +++ +I +FI + + Y++ E CP GSL +LL+ ++ + R Q I + Y+HS H LK N DS + LK+ DFGL
Sbjct: 106 IFAAKTVAKASIKSEK---TRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQ-ICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGL 225
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO34275 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SPS9]) HSP 1 Score: 532.717 bits (1371), Expect = 1.442e-177 Identity = 272/522 (52.11%), Postives = 369/522 (70.69%), Query Frame = 2
Query: 1952 NIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSN-YGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEI--DGCS-SDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEN 3505
NI Q+F ++K N+VA+K+IN R+ E T+E+ ++K ++ + ++++ F G CVEP + ++ +YCPKGSL+D+LENE I LD MF SL+ DIV+GM YLHS HG LKS NCVVD R+VLK+TD+GLN + Q + S EE + Y + LWT+PE+LR GT KGDVYSF II QE++ R G F + + +P +I+E V + PFRP L I +G + + ++ + K W+E+P++RPDF I+ ++RK+ GK+S NI+DN+++ +E+YANNLE LV +RT + +EK++ E+LL MLP SVA L+ + V+AE++++V+I+FSDIVGFTSLS++STP+QV++LLN LYT FD II N+DVYKVETIGDAYMVVSGLP NG HA EIA M L L I F I HRPN +L+LRIG+HSG AGVVG KMPRYCLFGDTVNT+SRMESNG LKIHIS ST +L + + +RG+V +KGKG +TYWL G +
Sbjct: 1 NINQRQIFTTVGIYKSNMVAIKRINK-RQIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPKGSLQDILENEDIKLDSMFVNSLLTDIVKGMAYLHSTEIRSHGRLKSPNCVVDGRWVLKITDYGLNKFKSNQ-DISEEEGEYAMYYRKLWTAPELLRAADPRPRGTQKGDVYSFGIIVQELLTRSGPFDLSYY-TNEPSDIIEKVTRVESPPFRPKLSTIVLEGPTVAGIVDLAKWCWEENPDHRPDFEEIRKTVRKLPMGKQS-NIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTENLLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVGSD 518
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO30985 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SZ80]) HSP 1 Score: 522.316 bits (1344), Expect = 5.129e-173 Identity = 260/500 (52.00%), Postives = 360/500 (72.00%), Query Frame = 2
Query: 2003 IVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKI-DKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAI-FRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWL 3493
+ AL K R + ++++LL++K+++D+ +D++ +FIG CV P + +V +YC +GSL+D+LEN+ + LD +F SL+ DIV+GM YLH S+ HG+LKSSNC+VDSR+VLK+TD+GL +LR K+++ E ++ +LW +PEILR + P GT KGDVYSF+II QE R G ++ + +PK I+E V+ S+ P+RP + + + +L ++KQ W EDP+ RPDF IK ++R+I DK NI DN+++ ME YA+NLE LVAQRT + ++EK++ + LL S+LP+ VA QL K ++V AES+ +VTIYFSDIVGFTSLSA+STPMQV+ LN LYT FD II+ +DVYKVETIGDAYMV SGLP NGR HA EIA+M L + A+ F++ H+P +L+LR+G H+GPV AGVVG+ M RYCLFGDTVNT+SRMESNG PL+IHIS T +VL TF++ RG+V +KGKG T+WL
Sbjct: 5 VAALPK----RTIDISRQLLLEMKQMRDIRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDLVFIASLLSDIVKGMEYLHNSDIRSHGNLKSSNCLVDSRWVLKITDYGLPLLRSRSKKSTIET----NWRDLLWVAPEILRIPSRPPKGTHKGDVYSFSIILQEFHTRDGPYS---ANYMEPKAIIEKVRKSEFPPYRPIVANLIDGAEELRDLMKQCWAEDPDLRPDFTEIKKTVRRIVDKSGMKKNIFDNMVNMMEIYADNLENLVAQRTDQLVDEKRKTDALLESILPRPVAEQLKKGKAVEAESFNEVTIYFSDIVGFTSLSAESTPMQVVTFLNDLYTIFDDIIQEYDVYKVETIGDAYMVASGLPIRNGRRHAGEIAKMALHLVDAVSHNFIVRHKPEYKLQLRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWL 493
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36203 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA1]) HSP 1 Score: 416.001 bits (1068), Expect = 5.753e-133 Identity = 217/470 (46.17%), Postives = 306/470 (65.11%), Query Frame = 2
Query: 1973 FIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQ--TLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLD-EIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGL 3370
F + + K +VALK + T++ML+++K+++D+ + ++ +IG+C P + +V +YC +GSL+++L N++I+LDW FR S DI GM +H S+ HG L+SS C++DSR+V K+ DFGLN+L+ Q+ + E H Y ++ W +PE+L+ + T + T GDVYSF II E++ R +A P E++E ++ + PFRP EI S + K++ Q W++DP RP F IK +R + GK S I+DN+L ME Y LE +V +RT++ +EK + ++LLY MLP+ +A L + + V AESY VTI+FSDIVGFT L+A STP+QV++LLN LYT FD+II+ DVYKVETIGDAYMVVSGLP NG HA EIA M L LS++ F H PN + LRIG+H+G AGVVG KMPRYCLFGDTVN +SRMES G+
Sbjct: 59 FCEHSFIKSYLVALKMLRKD-SLTLTRDMLIEMKQVRDVQHTNLLHYIGVCTTPPNICIVSQYCHRGSLQEILANDEISLDWFFRESFANDIAMGMHVIHTSSIHVHGDLRSSKCLIDSRWVCKVADFGLNLLKANQRPDP-EIGVHAQYSRLFWRAPELLQNEKSTNKPVPTQMGDVYSFGIILNELLTREEPYATTEFA---PIEVIERIRCHLNPPFRPETPFEIRNRS--VTKLMTQCWNDDPQARPTFSDIKRQLRLLKGGKSS--IVDNMLRLMENYTEQLETIVDERTRQLADEKAKTDELLYKMLPRYIAESLKRGEPVIAESYSSVTIFFSDIVGFTELAAASTPLQVVDLLNDLYTCFDTIIDKHDVYKVETIGDAYMVVSGLPVRNGHRHAGEIATMALNLLSSMGNFRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGDTVNYASRMESTGV 519
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36182 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA4]) HSP 1 Score: 409.453 bits (1051), Expect = 6.447e-131 Identity = 225/501 (44.91%), Postives = 312/501 (62.28%), Query Frame = 2
Query: 2069 IKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVK--------GDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEI--DGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRK--IDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPE 3532
+K ++DL++ ++ R++G+CVE + +V +C +G+L+DLL N+ I LDWMFR S DI GM +H S HG+LKSSNC++DSR+ K+TD+GL++LR Q E YK + WT+PE+L P K GDVYS+ I+ EII R ++ N D+ K+++E V+ + FRP + + ++++ + WD D RP F IK ++ + GK SG + SR Y NN LV R + K+ LL +L + +A +L K SVSAES++ VTI+FSDIVGFTS++A STP+QV++LLN+LYT FD +++ DVYKVETIGDAYMVVSGLP NG HA E+A M L LS + F IPH P+ +++LRIG+HSG AGVVG KMPRYCLFGDTVN +SRMES+GL L+IH+S EVL + + ERG V MKGKG +TY+L G++ F P+P+
Sbjct: 1 MKMVRDLHHANLNRYLGVCVESPNICMVSRFCNRGTLQDLLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPKDIGE--FAVYKNLFWTAPELL-----PLADGFKDRKNKTQAGDVYSYGIVLYEIITRDEPYST-NTDTLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKLKANGMGNGKISG-----MFSR---YYNNFSKLVISRMGVCMALKR----LL--VLSRPIADELKKGNSVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMKGKGTIVTYFLTGKDGFD-KPLPD 478
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36204 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA3]) HSP 1 Score: 409.068 bits (1050), Expect = 8.543e-131 Identity = 227/490 (46.33%), Postives = 305/490 (62.24%), Query Frame = 2
Query: 2078 IKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLE-----------LRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDF 3511
+ L++ +I +IG+C+ + +V E C +GSL D+L N+ I LDW F++S DI GM LH S HG+L SSNC+VD +V K+ D+GL R + EE K LW +PE +R + G+ GDVYSF +I EI+ R F + I+ + S++ P RP+L+ D C + K IKQ W E+P+ RP F IK SMRKI+ G+ S ++D++L +M+ Y+NNLE LV +RT++ EK + + LLY MLP+ VA QL +SV AE ++QVT++FSDIVGFT LS+ STP+QV+ LN LYT FD+II N+DVYKVETIGDAYMVVSGLP N HA EIA M L L I F I H P+T+L L + SGP AGVVG K PRY +FGDTVN +SRMESNG+P +IHIS + L + + M RGE+E+KGKGK +TY+L+G++ F
Sbjct: 2 VHKLSHVNINPYIGVCITAPNICIVSEACGRGSLADVLINDDIKLDWTFKMSFATDIAAGMEALHASEVSFHGNLTSSNCLVDRMWVCKIADYGLQ--RFSKHTYEPEEQLTGQTGKSLWMAPEHMRNAS--STGSQPGDVYSFGVILSEIVTRCEPFETLRATT----SILRRIMSTEFPPLRPTLNA-DDCDPTITKFIKQCWSEEPSARPTFRDIKKSMRKINGGR-SLRLVDSMLGKMDIYSNNLEVLVEERTRQLEAEKAKTDQLLYEMLPRPVADQLKSGKSVEAELFDQVTVFFSDIVGFTKLSSSSTPIQVVTFLNDLYTYFDNIIPNYDVYKVETIGDAYMVVSGLPEKNRDRHAGEIATMALHLLCDIRTFKIRHVPDTRLVSSYSLLLIITCLFYLIFSGPAVAGVVGIKKPRYDVFGDTVNVASRMESNGVPNRIHISAECRKALLNLGGYHMERRGEIELKGKGKVITYFLNGKDGF 481
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183]) HSP 1 Score: 615.535 bits (1586), Expect = 0.000e+0 Identity = 316/537 (58.85%), Postives = 394/537 (73.37%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
S SY SL+T G Q+F KT FKGN+VA+K +N ++ E T+++L+++K ++D+ +H+ RFIG C++P + +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH++Y GCHG+LKSSNCVVDSRFVLK+TD+GL R + + SH Y K LWT+PE+L P GT KGDVYSF II QEI R G F V++ D PKEIV+ V++ + FRP+ D S +L +++ W EDP RPDF IK M K++K + S +IL+NLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HAREIA M L L + F I HRPN QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S +T EVL F F + RG+VEMKGKGK TYWL GE
Sbjct: 475 SQRGSSYGSLITAQG-------KYQLFAKTGYFKGNLVAIKHVNK-KRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCENDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMD-LSPKEIVQKVRNGQRPYFRPTTDS-RFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNK-EGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGE 996 HSP 2 Score: 97.8265 bits (242), Expect = 3.770e-20 Identity = 77/277 (27.80%), Postives = 128/277 (46.21%), Query Frame = 2
Query: 923 LSEFVFIHI--DLFTGLNPRPWFDQKSSDE----VNESVRNAFR-----SMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
LSE +F+++ ++ ++ RP+ +++ E + E+ R+ F S+ ++ P N EY L A+ + + ++Y+ SFY+ +LYA+AL++ A+ + IT NR+F G V ID R D L+ + + ++G + V +YNGST+ + + I W PPLD P C F D C G++ + AL + G I F YR+LK + EL M W + WE L K+ + SR
Sbjct: 200 LSEGIFMNLKDEMNMTVSARPYTNEQDYKELVSFIKENGRSKFTHQYDTSVFVITYHPPDNPEY--KDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHW--PSCGPPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFG-ISSFLIYRKLKLEKELAGMLWRVQWEDLQFESPNKYHKRAGSR 471
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183]) HSP 1 Score: 615.15 bits (1585), Expect = 0.000e+0 Identity = 316/537 (58.85%), Postives = 394/537 (73.37%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNY-GCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGE 3502
S SY SL+T G Q+F KT FKGN+VA+K +N ++ E T+++L+++K ++D+ +H+ RFIG C++P + +V EYCP+GSL+D+LENE INLDWMFR SLI DIV+GM +LH++Y GCHG+LKSSNCVVDSRFVLK+TD+GL R + + SH Y K LWT+PE+L P GT KGDVYSF II QEI R G F V++ D PKEIV+ V++ + FRP+ D S +L +++ W EDP RPDF IK M K++K + S +IL+NLLSRMEQYANNLE LV +RTQ YLEEK++AE+LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFTS+SA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ HAREIA M L L + F I HRPN QL LRIG+H+GPVCAGVVG KMPRYCLFGDTVNT+SRMESNG LKIH+S +T EVL F F + RG+VEMKGKGK TYWL GE
Sbjct: 527 SQRGSSYGSLITAQG-------KYQLFAKTGYFKGNLVAIKHVNK-KRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRS----SCENDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMD-LSPKEIVQKVRNGQRPYFRPTTDS-RFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNK-EGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGE 1048 HSP 2 Score: 128.642 bits (322), Expect = 1.224e-29 Identity = 109/426 (25.59%), Postives = 188/426 (44.13%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADA-SSLKEIREKLKLLSSMSRVIIICGA-SKYTRLIMLAAVEIKLDLSEFVFIHIDLFTG--LNPRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISR 1696
F GP + L ++ R + + L++ G Y FE D +Y+ + RI + L F+ L + W R + +FY + +++ ++ + LK+ A ++ ++ +E + + R+I ICG + ++ L EI+ D + ++D+F + +PW + K D N F+S+ ++ P N EY L A+ + + ++Y+ SFY+ +LYA+AL++ A+ + IT NR+F G V ID R D L+ + + ++G + V +YNGST+ + + I W PPLD P C F D C G++ + AL + G I F YR+LK + EL M W + WE L K+ + SR
Sbjct: 113 VFFGPGCVYPLASVGRFV-SHWKLPLITAGGPAYGFEKLD--EYKTIVRIGPSTTKLGAFVNVLHTQFNWTSRA---VVIFYDLKQDDRPHYFLSEGIFMNLKDEMNMTVSARPYTNEQDYKELVSFIKENGRIIYICGPLETFLSIMKLFQSEIQ-DPESYAIFYLDVFAESLTHRKPWQNAKF-DWTNPI--QVFKSVFVITYHPPDNPEY--KDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHW--PSCGPPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFG-ISSFLIYRKLKLEKELAGMLWRVQWEDLQFESPNKYHKRAGSR 523
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819]) HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0 Identity = 309/539 (57.33%), Postives = 394/539 (73.10%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
S +Y SL+T+ G N Q++ KT +KGN+VA+K IN ++ E T+ +L ++K ++D++N+H+ RFIG CV+P + ++ EYCP+GSL+DL+E+E + LDWMFR SLI DIV+GM +LH S HG+LKSSNCVVDSRFVLK+TD+GL LR +S + +H YY + LWT+PE+LRT+ P GT KGDVYSF II QE+ +GVF +D + PKEI++ V RPSL S +L ++++ W E+P RPDF IK +RK +G S NILDNLLSRMEQYANNLE LV +RTQ Y EEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H RE+ARM L L A+ F I HRP+ QL LRIGVHSGPVCAGVVG KMPRYCLFGDTVNT+SRMES G LKIH+S +T +VL+ F TF + RGE+E+KGKG TYWL GE++
Sbjct: 529 SMKGSNYGSLMTMEG-------NLQIYTKTGYYKGNLVAIKYINK-KRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRT----SSCPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDT-HTLIPKEIIQGVIRGGVPLLRPSLC-FHSHSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDN 1052 HSP 2 Score: 154.451 bits (389), Expect = 1.469e-37 Identity = 125/444 (28.15%), Postives = 205/444 (46.17%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSD---YFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT----GLNP-RPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTL---------DRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPW-----ESLDTVEKRKHRQSQISRKDS 1705
AFIGP S +AR + T ++ +V+ G F ++ +T H+ L F K+ + + W H + + + D+K +D +++ + + + + + S +E ++++ RV+ +C + R +M+ + +DL +VF IDLF G P PWF D+ + + R AFRS+ ++ P N+EY L+K A + +NF+ N + FY+ +MLY+ ALN+ +K D +T MWNRTF G M V++D G+R DF+L+D+ D SG F+ V YN S + L +G + +W PPL+ P+C F D C + + +FVI + F YR+LK + EL A W + W +LD V +R + IS K S
Sbjct: 107 AFIGPGCDYSSSPVARFT-THWDVPMVTAGARADGFS-----KFAAVTNTGPTHKKLGEFSLKIQETFGW----HHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDYFVESNINHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWF---RGDQDDHAARLAFRSVKVLTYMEPQNAEY--HQFVETLKKDAEKMFNFTIKDSLYNLIAGGFYDGVMLYSRALNETLSKRKPGLRPVQRPKGDMVTQRMWNRTFQGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVVCVYNSSIKELVLQKGLNFQWPG--GSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQMSNLDKVLRRACSRLTISMKGS 533
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819]) HSP 1 Score: 609.372 bits (1570), Expect = 0.000e+0 Identity = 309/539 (57.33%), Postives = 394/539 (73.10%), Query Frame = 2
Query: 1895 SASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
S +Y SL+T+ G N Q++ KT +KGN+VA+K IN ++ E T+ +L ++K ++D++N+H+ RFIG CV+P + ++ EYCP+GSL+DL+E+E + LDWMFR SLI DIV+GM +LH S HG+LKSSNCVVDSRFVLK+TD+GL LR +S + +H YY + LWT+PE+LRT+ P GT KGDVYSF II QE+ +GVF +D + PKEI++ V RPSL S +L ++++ W E+P RPDF IK +RK +G S NILDNLLSRMEQYANNLE LV +RTQ Y EEK++AE LLY +LP SVA QL + ++V AE+++ VTIYFSDIVGFT+LSA+STP+QV+ LLN LYT FD+II+NFDVYKVETIGDAYMVVSGLP NG+ H RE+ARM L L A+ F I HRP+ QL LRIGVHSGPVCAGVVG KMPRYCLFGDTVNT+SRMES G LKIH+S +T +VL+ F TF + RGE+E+KGKG TYWL GE++
Sbjct: 470 SMKGSNYGSLMTMEG-------NLQIYTKTGYYKGNLVAIKYINK-KRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRT----SSCPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDT-HTLIPKEIIQGVIRGGVPLLRPSLC-FHSHSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDN 993 HSP 2 Score: 87.4261 bits (215), Expect = 6.329e-17 Identity = 107/433 (24.71%), Postives = 175/433 (40.42%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSD---YFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFT----GLNP-RPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPW-----ESLDTVEKRKHRQSQISRKDS 1705
AFIGP S +AR + T ++ +V+ G F ++ +T H+ L F K+ + + W H + + + D+K +D +++ + + + + + S +E ++++ RV+ +C + R +M+ + +DL +VF IDLF G P PWF D+ + + R AFR V+ P SI N YN S TT +S M + + +W G M V++D G+R DF+L+D+ D SG F E L +G + +W PPL+ P+C F D C + + +FVI + F YR+LK + EL A W + W +LD V +R + IS K S
Sbjct: 107 AFIGPGCDYSSSPVARFT-THWDVPMVTAGARADGFS-----KFAAVTNTGPTHKKLGEFSLKIQETFGW----HHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDYFVESNINHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWF---RGDQDDHAARLAFR----VRHP--------SIFNSF-----SVYNLS---------TTITPQSFM--------------QIKMCSEPVWCVVSAGVMGTVEMDKFGDREIDFALWDMTDINSGKF----------EVKHLPKGLNFQWPG--GSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQMSNLDKVLRRACSRLTISMKGS 474
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc2 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125799]) HSP 1 Score: 602.053 bits (1551), Expect = 0.000e+0 Identity = 306/541 (56.56%), Postives = 395/541 (73.01%), Query Frame = 2
Query: 1889 RGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLH-SNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGEND 3508
RGS +Y SL+T +G N QVF KT +KGNIVA+K N ++ E +++L ++K ++D+ N+H+ RFIG CV+P + ++ EYCP+GSL+D+LEN+ I L+WMF+ SLI DIV+GM++LH S HG LKSSNCVVD+RFVLK+TD+GL+ R+ S+ SH YY + LW +PE+LR + P GT KGDVYSF+II QE+ RRG F +D D PKEIV+ V RPS+D S +L +++++ W E+P RPDF I+ +RK +K + NILDNLLSRMEQYANNLE LV +RTQ Y EEK++AE LLY +LP SVA QL + ++V AE+++ V+IYFSDIVGFT+LSA+STPM+V+ LLN LYT FD++I+NFDVYKVETIGDAYMVVSGLP NG+ H REIARM L L + F I HRP QL+LRIG+HSGPVCAGVVG KMPRYCLFGDTVNTSSRMES+G LKIH+S +T +VL F +F + RG++++KGKGK TYWL GE+D
Sbjct: 539 RGS----NYGSLMTANG-------NLQVFAKTGYYKGNIVAIKYTNK-KRIELNRKVLFELKHMRDVQNEHLTRFIGACVDPPNICIITEYCPRGSLQDILENDSITLEWMFKFSLINDIVKGMVFLHNSVIFSHGKLKSSNCVVDNRFVLKITDYGLSTFRQESDVGSD---SHSYYAQKLWMAPELLRMENPPPQGTQKGDVYSFSIILQEVALRRGAFYLDG-DPLSPKEIVDRVILGDWPCLRPSIDP-QSHSPELGQLMQRCWAEEPTERPDFNHIRLLLRKHNKESRT-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVSIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMALALLDTVRTFRIRHRPEQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGESD 1061 HSP 2 Score: 145.591 bits (366), Expect = 8.649e-35 Identity = 113/414 (27.29%), Postives = 191/414 (46.14%), Query Frame = 2
Query: 455 AFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKE-MMERLKNYKTEGYKADASSLKE---IREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLF--TGLNPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALND---LYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDL-DPKSGNFQQVGFYNGSTETYSLIEGKSIEW-GNEKNEPPLDTPKCAF--DGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESL 1651
AFIGP + + + T ++ L++ G F D + Y +T H+ L F ++ + + W + + + + D+K Y A E + E LK+ + K + L + ++ RV+ +C + R +M+ + L ++VF++IDLF + N +PW D + ++AF+S+ I+ + P N EY DL+ A+ +N+S +N + FY+ +MLYA ALN+ + I+ MWNRTF+G + +D G+R +DF+L+DL D S +FQ V YN E + + G S+ W G + PLD PKC F D C + + T +F + + F R++K + EL A W I W+ +
Sbjct: 122 AFIGPGCSYTASPVGLFT-THWDVPLITAGAPA--IAFLDGI-YPTITNTGPTHKKLGRFALRICEHFGW----REYVTLMFSDNKEDDRPCYFAMEGLYEELKSINISLQDSVFEENKPPINYSQILADIQNIGRVMFVCCSPDVFRRLMIEFWKADLPHEQYVFLYIDLFAVSLSNKQPWARGDQDDTI---AKDAFQSVKILSYREPQNQEY--QQFVRDLKADAKTSFNYSVQDSLMNIIAGGFYDGLMLYAHALNETALVPGARPPGKLISGKMWNRTFHGVTGLLHLDVSGDRETDFALWDLVDTNSSSFQIVVVYNSFEEQVTPVPGTSVRWLGGAR---PLDVPKCGFKNDNPACLTKTITIHQMVSITLFFIFTMTLTIAIFICRKMKLEKELVAQLWRISWDDI 519
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000019264.1 (SMESG000019264.1) HSP 1 Score: 2360.1 bits (6115), Expect = 0.000e+0 Identity = 1167/1170 (99.74%), Postives = 1168/1170 (99.83%), Query Frame = 2
Query: 47 MCTRNHFGGWLIFILLIXXXXXXXXXXXXXITLLAGMGSYKCGKKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDQKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKIIQCE 3556
MCTRNHFGGWLIFILLISESNSSDNNDGNGITLLAGMGSYKCGKKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIE +KKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFD KSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGDKKLDKKDQKKKKSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKIIQCE
Sbjct: 1 MCTRNHFGGWLIFILLISESNSSDNNDGNGITLLAGMGSYKCGKKLSPREFRIAVLMTNSNLEKNNGNNMIVENSKKLGPITDLALARIENMKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKADASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPRPWFDPKSSDEVNESVRNAFRSMLIVKLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDRITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGDKKLDKKDQKKKKSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAKIIQCE 1170
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000056411.1 (SMESG000056411.1) HSP 1 Score: 989.949 bits (2558), Expect = 0.000e+0 Identity = 529/1094 (48.35%), Postives = 710/1094 (64.90%), Query Frame = 2
Query: 311 IEKLKKKGELQGFANYSLKLFFSESSTVSEHQNIMKRFFYFILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNH-ESLTNFM-GKLLKFYKWLPRPHKNIGVFYID--DKSYSDY-----FYSAKEMMERLKNYK----TEGYKADASSLKEIREKL-KLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLN--PRPWFDQKSSDEVNESVRNAFRSMLIVKL--PLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVP 3529
+EK++K + L+ +S + H+ + + F+ + P F GP + IAR+ +NR +++ G Y F ++ LTR+ H + T ++ +L YKW +K +F+ D + + Y Y K + +KN+ TE + D + I L + + + + + I+C R IML A + E++F++ID+F+ + RPW+ + +E NE + AFR+++ + L P +Y ++++ A+ +YNF+ E +N +SF+++++LYAL LND +K ++ + MWNR+F T V I +G+R +DFSL DL+ ++G F+ V Y G Y + K I+WG N+ PLDTP C +D S C K G + G I A I +IGG F +RR KFQAEL AMNWIIPW+ L+T EKR+ + S + N + + + + + E IE + + R ++ SN S SL TI G+ L+++ Q+F KTALFKGN+VALK IN K E T E+L++IKKIKD++NDHICRFIG+C++ H Y+VYEYCPKGSLED+L EQI LDWMF+ SL+QDI RGMIYLH+N+G HG+LKSSNC+VDSRFVLK+TDFGL L+ + +EEP+ YYK LWT+PE+L P GT+KGDVYSFA+I QEI+YR GVF++ + KEI E V++ PFRP+L DGC+ D++K+I+QAWDEDP +RPDF IK MRK++KG ++GNILDNLLSRMEQYANNLEGLVA+RT++YLEEK++AEDLLYSMLPK VAHQLIKNQ+V AESY+ VTI+FSDIVGFT+LSA+STPMQ+IELLNRLYTTFDSIIEN+DVYKVETIGDAYMV SGLP +NG H+REIARM + FL AI F+IPHRP+ +LELRIG+HSGPVC+GVVG KMPRYCLFGDTVNTSSRMESNGLPLKIHIS ST E+L +F TFI+SERG +++KGKG QLTYWLHGE+ IVDP+P
Sbjct: 73 LEKVRKMENINPIIKNIKILYPIDSDCLQTHKPLYESVINFVKEMPDVIF-GPICDYVIAPIARLMAF-WNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKW----NKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKY--KEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSN--IMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSKKKKHKLNKLRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGKIEITTELLIEIKKIKDMSNDHICRFIGVCLD--HPYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNM-YYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLP 1153
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1) HSP 1 Score: 984.941 bits (2545), Expect = 0.000e+0 Identity = 525/1069 (49.11%), Postives = 702/1069 (65.67%), Query Frame = 2
Query: 431 FILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLT--NFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYF---------YSAKEMMERLKNYKTEGYK--ADASSLKEIREKLKLLSSMSR---VIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPR--PWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKK--DGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKH--RQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNE-----SYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV-PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESA 3538
F+ P GP L IAR+ +N ++S G Y F + K +++ LTRI H L + K K YKW G++ +Y++ Y +E + + YK A+ + + L+ ++ V ++C I+L A ++ + E+VFI+I LF+ N PW+ S+ N + A+RS+L V K+P N ++ N S + ++++A +YN+ Y K+ +N ++FY+ ++LYA ALN A + I MWN TF G V ID+ G+R++DFS+ D+DPK+G F+ V + G+ ++ ++ S++WG+ N P P+C +D S+C K + G I LF+I G+F YR +K QAEL AMNWIIPWESL+T EK ++ + + + ++ + + + +S N +G++ EME LL+ S ++ N K+ G+ + S SL TI+G+ L+ IQN Q+F KTAL+KGN+VALK I + R+ + +++L+ +KK+KDLNNDHICRFIG C+E +QY+VY+YCPKGSLED+L EQI LDW+F+ SLIQDI RGM+YLH+N G G LKSSNC+VDSRFVLK+TDFGL LR K+ EE S+ Y+K +LWT+PE+LR P GT KGDVYSFAI+ QEI+YR+GVF++D+ D +EIVESVK+ PFRPSL I GC+ D + +IKQ+W+EDP RPDF IK MRK +K +SGNILDNLLSRMEQYANNLE +V +RT++YLEEKK+AEDLLYSMLPKSVAHQLIKNQ V+AESY+ VTI+FSDIVGFT+LSA+STPMQ+I+LLNRLYTTFDSIIEN+DVYKVETIGDAYMV SGLP +NG HAREIARM + FLSAIF FVIPHRP+ +L+LRIG+HSGPVC+GVVG KMPRYCLFGDTVNTSSRMESNGLP KIHIS STM++LK+F TF+M+ERG +E+KGKG TYWLHGEN+ IVDPVP+ A
Sbjct: 101 FVTQMP-DVLFGPICGYVLAPIARLLAF-WNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKW------THGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFS--DQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVK---------VHQSRSQNVKGTRN--EMENLHLLHEVEKPSS---KISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRG-SKQYLLEEDSNVYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPKDA 1144
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1) HSP 1 Score: 979.163 bits (2530), Expect = 0.000e+0 Identity = 524/1067 (49.11%), Postives = 694/1067 (65.04%), Query Frame = 2
Query: 431 FILDEPVHAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTRIAGNHESLT--NFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYF---------YSAKEMMERLKNYKTEGYK--ADASSLKEIREKLKLLSSMSR---VIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGLNPR--PWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKK--DGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKEKIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNE-----SYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQTLPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHV-PFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESA 3538
F+ P GP L IAR+ +N ++S G Y F + K +++ LTRI H L + K K YKW G++ +Y++ Y +E + + YK A+ + + L+ ++ V ++C I+L A ++ + E+VFI+I LF+ N PW+ S+ N + A+RS+L V K+P N ++ N S + ++++A +YN+ Y K+ +N ++FY+ ++LYA ALN A + I MWN TF G V ID+ G+R++DFS+ D+DPK+G F+ V + G+ ++ ++ S++WG+ N P P+C +D S+C K + G I LF+I G+F YR +K QAEL AMNWIIPWESL+T EK ++ L+N + + S+ + ME LL+ S ++ N K+ G+ + S SL TI+G+ L+ IQN Q+F KTAL+KGN+VALK I + R+ + +++L+ +KK+KDLNNDHICRFIG C+E +QY+VY+YCPKGSLED+L EQI LDW+F+ SLIQDI RGM+YLH+N G G LKSSNC+VDSRFVLK+TDFGL LR K+ EE S+ Y+K +LWT+PE+LR P GT KGDVYSFAI+ QEI+YR+GVF++D+ D +EIVESVK+ PFRPSL I GC+ D + +IKQ+W+EDP RPDF IK MRK +K +SGNILDNLLSRMEQYANNLE +V +RT++YLEEKK+AEDLLYSMLPKSVAHQLIKNQ V+AESY+ VTI+FSDIVGFT+LSA+STPMQ+I+LLNRLYTTFDSIIEN+DVYKVETIGDAYMV SGLP +NG HAREIARM + FLSAIF FVIPHRP+ +L+LRIG+HSGPVC+GVVG KMPRYCLFGDTVNTSSRMESNGLP KIHIS STM++LK+F TF+M+ERG +E+KGKG TYWLHGEN+ IVDPVP+ A
Sbjct: 101 FVTQMP-DVLFGPICGYVLAPIARLLAF-WNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKW------THGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFS--DQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRN---------------LVNHNCVKYQSKPIHNSKVKVHQSRSQ-NMENLHLLHEVEKPSS---KISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRG-SKQYLLEEDSNVYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPKDA 1137
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000068881.1 (SMESG000068881.1) HSP 1 Score: 949.888 bits (2454), Expect = 0.000e+0 Identity = 513/1049 (48.90%), Postives = 697/1049 (66.44%), Query Frame = 2
Query: 452 HAFIGPNSIISLGTIARMSGTRFNRSLVSLGEAGYQFEFKDKVQYQGLTR----IAGNHESLTNFMGKLLKFYKWLPRPHKNIGVFYIDDKSYSDYFYSAKEMMERLKNYKTEGYKA----DASSLKEIREKLKLLSSMSRVIIICGASKYTRLIMLAAVEIKLDLSEFVFIHIDLFTGL--NPRPWFDQKSSDEVNESVRNAFRSMLIV--KLPLNSEYWNSSIGNDLRKIAREKYNFSYPKEELNYVTTSFYESIMLYALALNDLYAKNDTLDR---ITNYMWNRTFNGFMTPVKIDAEGNRVSDFSLFDLDPKSGNFQQVGFYNGSTETYSLIEGKSIEWGNEKNEPPLDTPKCAFDGSLCKKDGTSTGLIFGCTTAALFVIGVIGGFFAYRRLKFQAELKAMNWIIPWESLDTVEKRKHRQSQISRKDSTVNETLINGXXXXXXXXXXXXXSGNYQGSKE---KIEMETTLLLNSPNSDSDIDPMVAIRNGKHRGSASNESYMSLVTISGVQLENIQNTQVFIKTALFKGNIVALKKINTGRKFETTKEMLLDIKKIKDLNNDHICRFIGMCVEPLHQYLVYEYCPKGSLEDLLENEQINLDWMFRLSLIQDIVRGMIYLHSNYGCHGHLKSSNCVVDSRFVLKLTDFGLNILREIQKENSNEEPSHEYYKKMLWTSPEILRTQT-LPFIGTVKGDVYSFAIIAQEIIYRRGVFAVDNCDSKDPKEIVESVKSSKHVPFRPSLDEIDGCSSDLIKIIKQAWDEDPNNRPDFPGIKNSMRKIDKGKESGNILDNLLSRMEQYANNLEGLVAQRTQEYLEEKKRAEDLLYSMLPKSVAHQLIKNQSVSAESYEQVTIYFSDIVGFTSLSADSTPMQVIELLNRLYTTFDSIIENFDVYKVETIGDAYMVVSGLPNVNGRNHAREIARMCLQFLSAIFRFVIPHRPNTQLELRIGVHSGPVCAGVVGHKMPRYCLFGDTVNTSSRMESNGLPLKIHISHSTMEVLKSFQTFIMSERGEVEMKGKGKQLTYWLHGENDFIVDPVPESAK 3541
+ + GP SL IAR+ + G +G + K + +Y LTR I +H L K+ + Y W + + Y ++++ ++ S + + +NYK + +K+ +A +L EI + S + V+++C + R I+L A ++ E+VFI+IDL T N +PW+ + +DEVN + A+RS+L V + P + EY N +++ EKY EE N F++S++LYALALND A N T + IT MWNRT G + ID G+R +D+S+ D+D +G F+ V Y G + Y +EG+ I+W N+KN PP P C ++ C G I T AA+ + +I GF+ Y+R+KFQAEL AMNW+IPW++++T EKR HR + V++TL N + + +Q SK K + E+ +L+ +P+ D+ +++ R ++ N S S + +G+Q +N+ + FI TAL+KGN+VALK+++ +K E + +L+++KK+K+LNN+HICRFIG+C++ +L+ EYCPKGSL+D+LENEQINLDWMF+ SL+QDI RGMIYLHSN G HG+LKSSNC+VDSRFVLK+ DFGL LR KE E + YY+ +LWT+PEILR T + + K DVYSF II QE++YR GVF + + + +PK+IVE V + +P+RP L E + CS L +II+Q+W ED + RPDF IK MR ++KG +SGNILDNLLSRMEQYANNLE LV QRT++YLEEK++ EDLLYSMLPKSVA QLI+N++V+AESYE V+IYFSDIVGFT+LSA+STPMQVIELLNRLYTTFDSIIE+FDVYKVETIGDAYMV SGLP NG H REIARM L FLSAIF F IPH+PN ++ELRIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNGLPLKIH+S +++VL++FQ FI+S+RG+V MKGKG Q TYWLHGE+ IVDP+PES +
Sbjct: 52 YVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHE-EYSTLTRVNSIIVTDH--LKVLFRKIFQMYNW-----SRVKLIY--EQTFLNFCRSVGTLFDS-ENYKNKTFKSVVLLNAETLLEID-----MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQN--FIKEVKNRTNEKYG---SVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKR-HRLTH------KVSDTLPNSELF----------TKRFQYSKRGLAKFDEESDVLIGNPSLAGDV-----VKSRPSRVNSINISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRG-TKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDINL-EPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPESCE 1055 The following BLAST results are available for this feature:
BLAST of Guanylate cyclase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Guanylate cyclase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30008651 ID=SMED30008651|Name=Guanylate cyclase|organism=Schmidtea mediterranea sexual|type=transcript|length=3660bpback to top protein sequence of SMED30008651-orf-1 >SMED30008651-orf-1 ID=SMED30008651-orf-1|Name=SMED30008651-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1171bp MCTRNHFGGWLIFILLISESNSSDNNDGNGITLLAGMGSYKCGKKLSPREback to top Aliases
The feature 'Guanylate cyclase' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
