Protein kinase domain-containing protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30008473 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: PHKG1 (phosphorylase kinase catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:8930]) HSP 1 Score: 372.474 bits (955), Expect = 1.059e-125 Identity = 195/381 (51.18%), Postives = 249/381 (65.35%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVD-SPNI---LRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY YEPKEI+G G SS VRRC+ + T EYAVK+IDV G SP LR +EV+ILR V+G P II+L D YE+ + FL+F+L +GELFD+L +VTLSEK TR IM + E + +H NIVHRDLKPENILLDDN+NIK+TDFG + + + E L+E+ GTP YLAPE + N++ P YG+ VD+W+ GVIMYTLL G PPFWHRKQ LMLR IM Y F SPEWDD S KDL+ + L+V P R + EAL H FFQ L+ ++ + FS PR KFK VIA +++ +R + R+ +T + +PY R LR+LID AF IY HWVKKG++QNRAA+F+ TPK
Sbjct: 13 AQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQ---QYLVEEV--RHFS----------PRGKFK--VIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: PHKG2 (phosphorylase kinase catalytic subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:8931]) HSP 1 Score: 370.548 bits (950), Expect = 9.191e-125 Identity = 192/395 (48.61%), Postives = 256/395 (64.81%), Query Frame = 2
Query: 107 MTLS-GDDDTSKKYC--EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTP 1270
MTL G +D + + FY KY+PK++IG G SS VRRC+ R T E+AVKI++V + SP L R RE ILR VAG P+II L D YES +MFL+F+L KGELFD+L +V LSEK TR IM + EAV+F+H+ NIVHRDLKPENILLDDN+ I+++DFG + + E+L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVI++TLL G PPFWHR+Q LMLR IME +Y F SPEWDD S KDLI ++L V+P R+ + +AL H FF+ E ++ + PR++F+ V + +++ R R+ +T + +PY R++R LID AF +Y HWVKKGE+QNRAA+FQ P
Sbjct: 1 MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWN---------------LTPRQRFR--VAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRP 378
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: PHKG1 (phosphorylase kinase catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:8930]) HSP 1 Score: 366.696 bits (940), Expect = 1.826e-123 Identity = 195/384 (50.78%), Postives = 249/384 (64.84%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVD-SPNI---LRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFEL---CPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY YEPKEI+G G SS VRRC+ + T EYAVK+IDV G SP LR +EV+ILR V+G P II+L D YE+ + FL+F+L +GELFD+L +VTLSEK TR IM + E + +H NIVHRDLKPENILLDDN+NIK+TDFG + + + E L+E+ GTP YLAPE + N++ P YG+ VD+W+ GVIMYTLL G PPFWHRKQ LMLR IM Y F SPEWDD S KDL+ + L+V P R + EAL H FFQ L+ ++ + FS PR KFK VIA +++ +R + R+ +T + +PY R LR+LID AF IY HWVKKG++QNRAA+F+ TPK
Sbjct: 13 AQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLFHRMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQ---QYLVEEV--RHFS----------PRGKFK--VIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPK 379
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: PHKG2 (phosphorylase kinase catalytic subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:8931]) HSP 1 Score: 364.77 bits (935), Expect = 1.759e-122 Identity = 192/399 (48.12%), Postives = 256/399 (64.16%), Query Frame = 2
Query: 107 MTLS-GDDDTSKKYC--EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDV----WACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTP 1270
MTL G +D + + FY KY+PK++IG G SS VRRC+ R T E+AVKI++V + SP L R RE ILR VAG P+II L D YES +MFL+F+L KGELFD+L +V LSEK TR IM + EAV+F+H+ NIVHRDLKPENILLDDN+ I+++DFG + + E+L+E+ GTPGYLAPE L ++ P YG+ VD+ WACGVI++TLL G PPFWHR+Q LMLR IME +Y F SPEWDD S KDLI ++L V+P R+ + +AL H FF+ E ++ + PR++F+ V + +++ R R+ +T + +PY R++R LID AF +Y HWVKKGE+QNRAA+FQ P
Sbjct: 1 MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLLFPSWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWN---------------LTPRQRFR--VAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRP 382
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: PHKG1 (phosphorylase kinase catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:8930]) HSP 1 Score: 355.91 bits (912), Expect = 6.904e-119 Identity = 197/413 (47.70%), Postives = 250/413 (60.53%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVD-SPNI---LRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFEL------------------CPK--------------GELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY YEPKEI+G G SS VRRC+ + T EYAVK+IDV G SP LR +EV+ILR V+G P II+L D YE+ + FL+F+L PK GELFD+L +VTLSEK TR IM + E + +H NIVHRDLKPENILLDDN+NIK+TDFG + + + E L+E+ GTP YLAPE + N++ P YG+ VD+W+ GVIMYTLL G PPFWHRKQ LMLR IM Y F SPEWDD S KDL+ + L+V P R + EAL H FFQ L+ ++ + FS PR KFK VIA +++ +R + R+ +T + +PY R LR+LID AF IY HWVKKG++QNRAA+F+ TPK
Sbjct: 13 AQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLWEDTDTMEMEQKWCLGWDSPKSTNFRAQGRARMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQ---QYLVEEV--RHFS----------PRGKFK--VIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPK 408
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: Y50D7A.3 (pep chromosome:WBcel235:III:254535:264636:1 gene:WBGene00021753.1 transcript:Y50D7A.3a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y50D7A.3) HSP 1 Score: 304.679 bits (779), Expect = 1.898e-98 Identity = 163/409 (39.85%), Postives = 250/409 (61.12%), Query Frame = 2
Query: 86 ILLVNSDMTLSGDDDTSKKYC----EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPN---ILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFF------QTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+L+V++D D D S+ Y + F + YE KE++G G +STVRRC+++ + +AVKI+D+++ S N L E EVEILR ++G P II++HDFY++ ++F +FE+ P+GELFD LN+ VT+SEKR R +M Q+F+ V ++H+++IVHRDLK ENIL D I I+DFG A + ++L+++ GTPGYLAPE + + DN Y VD WA GVIMYTLL GC PF+HRKQ +MLR I + K+ F + +W +I+ K+LI ++L V+ +RI S E L HE+ Q + V + ++ L QTS R++FK+ +I + RL K + +I ++ P+ +R++R ++ F +Y HWV +G +R +F P+
Sbjct: 3 MLIVDTDHE---DSDESQHYRHEEDQGFNAAYESKEVLGRGLASTVRRCIEKGSGQHFAVKIVDISTEKQSENEAKRLLEETISEVEILRQLSGHPSIIKIHDFYQTPSFLFAVFEMAPRGELFDVLNSTVTVSEKRARRLMKQLFDGVEYMHARDIVHRDLKLENILCIDEERIVISDFGFATRIPRGKKLRDLCGTPGYLAPETIRCQWYDNAEGYSLEVDEWALGVIMYTLLAGCAPFYHRKQLMMLRLIQQGKFEFRNEQWANITAEAKNLITQLLQVDATKRISSKECLAHEWMIPIAQQQAPQMVPVVEVELVK-DQTS-----ERARKRFKTAIIWVRFFQRLAKYKYL-KTVIDRDVLRKRPFRDRDIRHEAESSMFSVYGHWVNRGFYYSRDMLFANKPR 401
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-43 (Calcium/calmodulin-dependent protein kinase type II [Source:UniProtKB/Swiss-Prot;Acc:O62305]) HSP 1 Score: 223.787 bits (569), Expect = 8.827e-69 Identity = 123/318 (38.68%), Postives = 176/318 (55.35%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFKSVVIAYQLISR 1093
F Y+ KE +G GA S VRRC+ + T +E+A KII+ + + + + E RE I R + P I+ LHD + E + +L+F+L GELF+ + AR SE + QI E++ + HS IVHRDLKPEN+LL +K+ DFGLA++ ++ E GTPGYL+PE L + PY +PVD+WACGVI+Y LLVG PPFW QH + QI Y + SPEWD ++ K LI +L VNP +RI + +AL + +E V + + V + N RRK K ++ + +R
Sbjct: 8 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLE--REARICRKLQ-HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL------KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERV------ASAIHRQDTVDCLKKFNARRKLKGAILTTMIATR 309
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-43 (Calcium/calmodulin-dependent protein kinase type II [Source:UniProtKB/Swiss-Prot;Acc:O62305]) HSP 1 Score: 223.787 bits (569), Expect = 8.827e-69 Identity = 123/318 (38.68%), Postives = 176/318 (55.35%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFKSVVIAYQLISR 1093
F Y+ KE +G GA S VRRC+ + T +E+A KII+ + + + + E RE I R + P I+ LHD + E + +L+F+L GELF+ + AR SE + QI E++ + HS IVHRDLKPEN+LL +K+ DFGLA++ ++ E GTPGYL+PE L + PY +PVD+WACGVI+Y LLVG PPFW QH + QI Y + SPEWD ++ K LI +L VNP +RI + +AL + +E V + + V + N RRK K ++ + +R
Sbjct: 8 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLE--REARICRKLQ-HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL------KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERV------ASAIHRQDTVDCLKKFNARRKLKGAILTTMIATR 309
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-43 (Calcium/calmodulin-dependent protein kinase type II [Source:UniProtKB/Swiss-Prot;Acc:O62305]) HSP 1 Score: 223.787 bits (569), Expect = 8.827e-69 Identity = 123/318 (38.68%), Postives = 176/318 (55.35%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFKSVVIAYQLISR 1093
F Y+ KE +G GA S VRRC+ + T +E+A KII+ + + + + E RE I R + P I+ LHD + E + +L+F+L GELF+ + AR SE + QI E++ + HS IVHRDLKPEN+LL +K+ DFGLA++ ++ E GTPGYL+PE L + PY +PVD+WACGVI+Y LLVG PPFW QH + QI Y + SPEWD ++ K LI +L VNP +RI + +AL + +E V + + V + N RRK K ++ + +R
Sbjct: 8 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLE--REARICRKLQ-HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL------KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERV------ASAIHRQDTVDCLKKFNARRKLKGAILTTMIATR 309
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: unc-43 (Calcium/calmodulin-dependent protein kinase type II [Source:UniProtKB/Swiss-Prot;Acc:O62305]) HSP 1 Score: 228.409 bits (581), Expect = 1.664e-68 Identity = 124/319 (38.87%), Postives = 180/319 (56.43%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFKSVVIAYQLISRL 1096
F Y+ KE +G GA S VRRC+ + T +E+A KII+ + + + + E RE I R + P I+ LHD + E + +L+F+L GELF+ + AR SE + QI E++ + HS IVHRDLKPEN+LL +K+ DFGLA++ ++ E GTPGYL+PE L + PY +PVD+WACGVI+Y LLVG PPFW QH + QI Y + SPEWD ++ K LI +L VNP +RI + +AL + +E V + + V + N RRK K+ + A ++++R+
Sbjct: 8 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLE--REARICRKLQ-HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL------KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERV------ASAIHRQDTVDCLKKFNARRKLKAAISAVKMVTRM 310
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0090002) HSP 1 Score: 402.519 bits (1033), Expect = 2.007e-137 Identity = 209/404 (51.73%), Postives = 273/404 (67.57%), Query Frame = 2
Query: 122 DDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN----SGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQT--------SIVSTV--------INPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
D D +K FY+KYEPKEI+G G SSTVRRC++++T E+A KIID+ SG +P + +E+ ILR V G PYII+L D +ES+ ++FL+FELCPKGELFD+L + VTLSEK+TR IM QIFE V +IH+K+IVHRDLKPENILLD+N N+KITDFG A + E+L + GTPGYLAPE L + P Y Q VD+WACGVIM+TLLVGCPPFWHRKQ +MLR IME KYSF SPEW DIS+ PKDLI+K L+V+P+QRI E L H FF N +L++ N+ ++ S ++ + N R+KF+ ++ + I R+R++ + E +PY + LRK+ID AF +Y HWVKKGE QNRAA+F+ TP+
Sbjct: 12 DKDAAKG----FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF----NQMLFEQNIDGLKRSLSTKSRRMSRITEIALLRKQSRFNARKKFQFAILVIRAIIRIRRLRFTAEPL-HVEEAIRDPYRVKVLRKVIDGCAFRVYGHWVKKGEGQNRAALFENTPR 406
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0343648) HSP 1 Score: 402.519 bits (1033), Expect = 2.007e-137 Identity = 209/404 (51.73%), Postives = 273/404 (67.57%), Query Frame = 2
Query: 122 DDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN----SGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQT--------SIVSTV--------INPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
D D +K FY+KYEPKEI+G G SSTVRRC++++T E+A KIID+ SG +P + +E+ ILR V G PYII+L D +ES+ ++FL+FELCPKGELFD+L + VTLSEK+TR IM QIFE V +IH+K+IVHRDLKPENILLD+N N+KITDFG A + E+L + GTPGYLAPE L + P Y Q VD+WACGVIM+TLLVGCPPFWHRKQ +MLR IME KYSF SPEW DIS+ PKDLI+K L+V+P+QRI E L H FF N +L++ N+ ++ S ++ + N R+KF+ ++ + I R+R++ + E +PY + LRK+ID AF +Y HWVKKGE QNRAA+F+ TP+
Sbjct: 12 DKDAAKG----FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF----NQMLFEQNIDGLKRSLSTKSRRMSRITEIALLRKQSRFNARKKFQFAILVIRAIIRIRRLRFTAEPL-HVEEAIRDPYRVKVLRKVIDGCAFRVYGHWVKKGEGQNRAALFENTPR 406
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0343587) HSP 1 Score: 398.667 bits (1023), Expect = 2.771e-136 Identity = 206/390 (52.82%), Postives = 264/390 (67.69%), Query Frame = 2
Query: 122 DDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN----SGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRD 1279
D D +K FY+KYEPKEI+G G SSTVRRC++++T E+A KIID+ SG +P + +E+ ILR V G PYII+L D +ES+ ++FL+FELCPKGELFD+L + VTLSEK+TR IM QIFE V +IH+K+IVHRDLKPENILLD+N N+KITDFG A + E+L + GTPGYLAPE L + P Y Q VD+WACGVIM+TLLVGCPPFWHRKQ +MLR IME KYSF SPEW DIS+ PKDLI+K L+V+P+QRI E L H F F+Q + N R+KF+ ++ + I R+R++ + E +PY + LRK+ID AF +Y HWVKKGE QNRAA+F+ TP+ +
Sbjct: 12 DKDAAKG----FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPF----------------FNQMLRKQSRFNARKKFQFAILVIRAIIRIRRLRFTAEPL-HVEEAIRDPYRVKVLRKVIDGCAFRVYGHWVKKGEGQNRAALFENTPRTE 380
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0301501) HSP 1 Score: 359.377 bits (921), Expect = 1.385e-118 Identity = 175/294 (59.52%), Postives = 216/294 (73.47%), Query Frame = 2
Query: 122 DDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN----SGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYD 991
D D +K FY+KYEPKEI+G G SSTVRRC++++T E+A KIID+ SG +P + +E+ ILR V G PYII+L D +ES+ ++FL+FELCPKGELFD+L + VTLSEK+TR IM QIFE V +IH+K+IVHRDLKPENILLD+N N+KITDFG A + E+L + GTPGYLAPE L + P Y Q VD+WACGVIM+TLLVGCPPFWHRKQ +MLR IME KYSF SPEW DIS+ PKDLI+K L+V+P+QRI E L H FF + VL+ D
Sbjct: 12 DKDAAKG----FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF--NQMVLMGD 299 HSP 2 Score: 60.4622 bits (145), Expect = 1.821e-9 Identity = 26/47 (55.32%), Postives = 34/47 (72.34%), Query Frame = 2
Query: 1139 EMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRD 1279
E +PY + LRK+ID AF +Y HWVKKGE QNRAA+F+ TP+ +
Sbjct: 503 EAIRDPYRVKVLRKVIDGCAFRVYGHWVKKGEGQNRAALFENTPRTE 549
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0301500) HSP 1 Score: 359.377 bits (921), Expect = 1.385e-118 Identity = 175/294 (59.52%), Postives = 216/294 (73.47%), Query Frame = 2
Query: 122 DDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN----SGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYD 991
D D +K FY+KYEPKEI+G G SSTVRRC++++T E+A KIID+ SG +P + +E+ ILR V G PYII+L D +ES+ ++FL+FELCPKGELFD+L + VTLSEK+TR IM QIFE V +IH+K+IVHRDLKPENILLD+N N+KITDFG A + E+L + GTPGYLAPE L + P Y Q VD+WACGVIM+TLLVGCPPFWHRKQ +MLR IME KYSF SPEW DIS+ PKDLI+K L+V+P+QRI E L H FF + VL+ D
Sbjct: 12 DKDAAKG----FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF--NQMVLMGD 299 HSP 2 Score: 60.4622 bits (145), Expect = 1.821e-9 Identity = 26/47 (55.32%), Postives = 34/47 (72.34%), Query Frame = 2
Query: 1139 EMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRD 1279
E +PY + LRK+ID AF +Y HWVKKGE QNRAA+F+ TP+ +
Sbjct: 503 EAIRDPYRVKVLRKVIDGCAFRVYGHWVKKGEGQNRAALFENTPRTE 549
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: phkg2 (phosphorylase kinase, gamma 2 (testis) [Source:ZFIN;Acc:ZDB-GENE-040426-825]) HSP 1 Score: 367.851 bits (943), Expect = 3.880e-124 Identity = 188/401 (46.88%), Postives = 260/401 (64.84%), Query Frame = 2
Query: 119 GDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFF--QTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQN 1306
GD+ + FY KY+PKE+IG G SS VRRC+ + T E+AVKII++ + + L ++ +E+ +L LV G P II L D YES ++FL+F+L +GELFD+L +VTLSEK TR +M + EAV ++H+ NIVHRDLKPENILLDD ++K++DFG +V+ E+L+E+ GTPGYLAPE L ++ YG+ VD+WACGVI++TLL G PPFWHRKQ LMLR IME +Y F SPEWDD S KDLI ++L+V P R+ + +AL H FF +E+V L+ +PR+ FK++++ R++ + R +T + +PY R +RKLID AF IY HWVKKGE+QNRAA+FQ T K +G ++L+N
Sbjct: 8 GDELPDWVGAKEFYQKYDPKEVIGRGVSSVVRRCVHKHTGQEFAVKIIEITAEKMTEQQLEEVKSSTLKEIHVLNLVKGHPSIITLIDSYESTAFIFLVFDLMRRGELFDYLTEKVTLSEKETRSMMRALLEAVQYLHALNIVHRDLKPENILLDDQGHLKLSDFGFSVQLGPDEKLRELCGTPGYLAPEILKCSMDETHEGYGKEVDLWACGVILFTLLAGSPPFWHRKQLLMLRMIMEGRYQFSSPEWDDRSDTVKDLISRLLVVEPTLRLTAEQALAHPFFCQYQKEDVRLF-----------------SPRKTFKALILTVLACIRMQCRYYRAR-PLTKELLSRDPYSIRGVRKLIDGCAFRIYGHWVKKGEQQNRAALFQNTAKIILLGLEDLEN 390
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: phkg1a (phosphorylase kinase, gamma 1a (muscle) [Source:ZFIN;Acc:ZDB-GENE-061103-385]) HSP 1 Score: 366.311 bits (939), Expect = 1.837e-123 Identity = 190/384 (49.48%), Postives = 251/384 (65.36%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNI-----LRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY KY+PKEI+G G SS VRRC+ ++T EYAVK+ID+ D N +R +E++IL+ V GQ II+L D +E++ + FL+F+L KGELFD+L +VTLSEK TR IM + E V F+HS+NIVHRDLKPENILLDDN+NIK+TDFG AV+ ++L E+ GTPGYLAPE + + + YG VD+W+ GVIM+TLL G PPFWHRKQ LMLR I+ Y F SPEWDD S KDLI K+L+VNP +R +++AL H FFQ +V+ V +P RKFK VI +++ +R R +T +K++PY + +RKLID AF IY HWVKKG+ QNRAA+F+ +PK
Sbjct: 13 AQDFYQKYDPKEILGRGVSSVVRRCIHKRTTQEYAVKVIDITPS-DKMNTEEIEEIRNATIKEIDILKKVCGQENIIQLKDCFETKAFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRSLLEVVQFLHSQNIVHRDLKPENILLDDNMNIKLTDFGFAVQIAPGQKLNEVCGTPGYLAPEIIECSMDPHHQGYGAAVDLWSAGVIMFTLLAGSPPFWHRKQMLMLRMILAGNYQFTSPEWDDRSDTVKDLISKMLVVNPEKRFTATDALNHPFFQQY-----------------VVAEVRHFSPYRKFK--VICMTVLATMRIYCNYRRAKPVTKEVIKSDPYAVKPIRKLIDACAFKIYGHWVKKGQTQNRAALFENSPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: phkg1a (phosphorylase kinase, gamma 1a (muscle) [Source:ZFIN;Acc:ZDB-GENE-061103-385]) HSP 1 Score: 366.311 bits (939), Expect = 1.837e-123 Identity = 190/384 (49.48%), Postives = 251/384 (65.36%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNI-----LRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY KY+PKEI+G G SS VRRC+ ++T EYAVK+ID+ D N +R +E++IL+ V GQ II+L D +E++ + FL+F+L KGELFD+L +VTLSEK TR IM + E V F+HS+NIVHRDLKPENILLDDN+NIK+TDFG AV+ ++L E+ GTPGYLAPE + + + YG VD+W+ GVIM+TLL G PPFWHRKQ LMLR I+ Y F SPEWDD S KDLI K+L+VNP +R +++AL H FFQ +V+ V +P RKFK VI +++ +R R +T +K++PY + +RKLID AF IY HWVKKG+ QNRAA+F+ +PK
Sbjct: 13 AQDFYQKYDPKEILGRGVSSVVRRCIHKRTTQEYAVKVIDITPS-DKMNTEEIEEIRNATIKEIDILKKVCGQENIIQLKDCFETKAFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRSLLEVVQFLHSQNIVHRDLKPENILLDDNMNIKLTDFGFAVQIAPGQKLNEVCGTPGYLAPEIIECSMDPHHQGYGAAVDLWSAGVIMFTLLAGSPPFWHRKQMLMLRMILAGNYQFTSPEWDDRSDTVKDLISKMLVVNPEKRFTATDALNHPFFQQY-----------------VVAEVRHFSPYRKFK--VICMTVLATMRIYCNYRRAKPVTKEVIKSDPYAVKPIRKLIDACAFKIYGHWVKKGQTQNRAALFENSPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: phkg1a (phosphorylase kinase, gamma 1a (muscle) [Source:ZFIN;Acc:ZDB-GENE-061103-385]) HSP 1 Score: 366.311 bits (939), Expect = 1.837e-123 Identity = 190/384 (49.48%), Postives = 251/384 (65.36%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNI-----LRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY KY+PKEI+G G SS VRRC+ ++T EYAVK+ID+ D N +R +E++IL+ V GQ II+L D +E++ + FL+F+L KGELFD+L +VTLSEK TR IM + E V F+HS+NIVHRDLKPENILLDDN+NIK+TDFG AV+ ++L E+ GTPGYLAPE + + + YG VD+W+ GVIM+TLL G PPFWHRKQ LMLR I+ Y F SPEWDD S KDLI K+L+VNP +R +++AL H FFQ +V+ V +P RKFK VI +++ +R R +T +K++PY + +RKLID AF IY HWVKKG+ QNRAA+F+ +PK
Sbjct: 13 AQDFYQKYDPKEILGRGVSSVVRRCIHKRTTQEYAVKVIDITPS-DKMNTEEIEEIRNATIKEIDILKKVCGQENIIQLKDCFETKAFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRSLLEVVQFLHSQNIVHRDLKPENILLDDNMNIKLTDFGFAVQIAPGQKLNEVCGTPGYLAPEIIECSMDPHHQGYGAAVDLWSAGVIMFTLLAGSPPFWHRKQMLMLRMILAGNYQFTSPEWDDRSDTVKDLISKMLVVNPEKRFTATDALNHPFFQQY-----------------VVAEVRHFSPYRKFK--VICMTVLATMRIYCNYRRAKPVTKEVIKSDPYAVKPIRKLIDACAFKIYGHWVKKGQTQNRAALFENSPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: phkg1b (phosphorylase kinase, gamma 1b (muscle) [Source:ZFIN;Acc:ZDB-GENE-050522-52]) HSP 1 Score: 358.607 bits (919), Expect = 2.223e-120 Identity = 183/385 (47.53%), Postives = 254/385 (65.97%), Query Frame = 2
Query: 149 EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN-SGVDSPNILR---AECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFK----SVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY KY+PKEI+G G SS VRRC+D++T EYAVKIID+ S +P ++ +E++ILR V+GQ II+L D +ES+ + FL+F+L +GELFD+L +VTLSEK TR I+ + E V ++H+ NIVHRDLKPENILLDD++NIK+TDFG +++ + + L E+ GTPGYLAPE + + YG VD+W+ GVI+YTLL G PPFWHRKQ LMLR I+ +Y F+SPEWDD S KDLI ++L+V+P R ++EAL H FF Q +V+ V +P RKFK +V+ A ++ R+ +T ++++PY ++LRK+ID AF IY HWVKKG+ QNRAA+F+ +PK
Sbjct: 14 QEFYDKYDPKEILGRGVSSVVRRCVDKRTGQEYAVKIIDITPSDKMTPQEIQEIQQATVKEIDILRKVSGQKNIIQLKDCFESKAFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIIRALLEVVEYLHAHNIVHRDLKPENILLDDDVNIKLTDFGFSIQIEPGQRLNEVCGTPGYLAPEIIECSMDPKHSGYGTAVDLWSTGVILYTLLAGSPPFWHRKQMLMLRLILAGQYQFNSPEWDDRSDTVKDLISRLLVVDPESRYTATEALNHPFF-----------------QQYVVAEVRHFSPYRKFKVICRTVLAAMRIYCNYRRAK-----PVTKEVIQSDPYAIKHLRKMIDACAFKIYGHWVKKGQTQNRAALFENSPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: phkg1 (phosphorylase kinase, gamma 1 (muscle) [Source:NCBI gene;Acc:448255]) HSP 1 Score: 374.015 bits (959), Expect = 2.418e-126 Identity = 192/379 (50.66%), Postives = 255/379 (67.28%), Query Frame = 2
Query: 149 EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSG-VDSPNI--LRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY KYEPKEI+G G SS VRRC+ + ++ ++AVKIID+ + S I LR +E++IL+ V+G P +I+L D YES + FL+F+L +GELFD+L +VTLSEK TR IM + E V+ +H+ NIVHRDLKPENILLDD++NIK+TDFG + + E+LKEI GTPGYLAPE L ++N YG+ VD+W+CGVIMYTLL G PPFWHRKQ LMLR IM +Y F SPEWDD S KDLI ++L+VNP +R+ + EAL H FFQ YD+ + +P RKFK V+ +++ +R H ++ +T + +PY + +RKLID AF IY HWVKKGE+QNRAA+F+ T K
Sbjct: 14 QEFYEKYEPKEILGRGVSSVVRRCIFKPSREDFAVKIIDITGDHLSSEQIAELRDSTVKEIDILKKVSGFPNVIQLKDSYESHTFFFLVFDLMRRGELFDYLTEKVTLSEKETRKIMRSLLEVVSKLHAYNIVHRDLKPENILLDDDMNIKLTDFGFSCQIQEGEKLKEICGTPGYLAPEILHCSMDENHSGYGKQVDMWSCGVIMYTLLAGSPPFWHRKQMLMLRMIMSGEYHFGSPEWDDRSDTVKDLIARLLVVNPERRLTADEALIHPFFQQ------YDVEEVRY---------FSPFRKFK--VVCLTVLASVRIYHYYRKVKPVTKEIIVRDPYAIKPIRKLIDGCAFRIYGHWVKKGEQQNRAALFENTAK 375
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: phkg1 (phosphorylase kinase, gamma 1 (muscle) [Source:NCBI gene;Acc:448255]) HSP 1 Score: 374.785 bits (961), Expect = 2.674e-126 Identity = 195/392 (49.74%), Postives = 259/392 (66.07%), Query Frame = 2
Query: 149 EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSG-VDSPNI--LRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQ 1312
+ FY KYEPKEI+G G SS VRRC+ + ++ ++AVKIID+ + S I LR +E++IL+ V+G P +I+L D YES + FL+F+L +GELFD+L +VTLSEK TR IM + E V+ +H+ NIVHRDLKPENILLDD++NIK+TDFG + + E+LKEI GTPGYLAPE L ++N YG+ VD+W+CGVIMYTLL G PPFWHRKQ LMLR IM +Y F SPEWDD S KDLI ++L+VNP +R+ + EAL H FFQ YD+ + +P RKFK V+ +++ +R H ++ +T + +PY + +RKLID AF IY HWVKKGE+QNRAA+F+ T + HD L D
Sbjct: 14 QEFYEKYEPKEILGRGVSSVVRRCIFKPSREDFAVKIIDITGDHLSSEQIAELRDSTVKEIDILKKVSGFPNVIQLKDSYESHTFFFLVFDLMRRGELFDYLTEKVTLSEKETRKIMRSLLEVVSKLHAYNIVHRDLKPENILLDDDMNIKLTDFGFSCQIQEGEKLKEICGTPGYLAPEILHCSMDENHSGYGKQVDMWSCGVIMYTLLAGSPPFWHRKQMLMLRMIMSGEYHFGSPEWDDRSDTVKDLIARLLVVNPERRLTADEALIHPFFQQ------YDVEEVRY---------FSPFRKFK--VVCLTVLASVRIYHYYRKVKPVTKEIIVRDPYAIKPIRKLIDGCAFRIYGHWVKKGEQQNRAALFENT---QHVAHDPLVGDH 385
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: xpo5 (exportin 5 [Source:Xenbase;Acc:XB-GENE-5947328]) HSP 1 Score: 369.392 bits (947), Expect = 1.869e-124 Identity = 193/392 (49.23%), Postives = 248/392 (63.27%), Query Frame = 2
Query: 107 MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
M + D+ + FY KY+PKEIIG G SSTVRRC+ R+T +YAVKII+V SP L R +E+EIL V+ P II L D YES ++FL+F+L +GELFD+L +VTLSEK TR IM + EAVT++HS NIVHRDLKPENIL+DD LNIK++DFG + E+L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVIM+TLL G PPFWHRKQ LMLR IM+ ++ F SPEWDD S KDLI ++L V P +R+ + +AL H FFQ+ + T + P +F+ A R+ R + T M++ PY + +R+LID AF IY HWVKKGE QNRAA+FQ PK
Sbjct: 1 MVFARDELPDWAGAKEFYQKYDPKEIIGRGVSSTVRRCIHRETGRQYAVKIIEVTPERLSPEQLKEVRLSTAKEMEILHHVSNHPSIISLIDSYESSTFIFLVFDLMKRGELFDYLTEKVTLSEKETRCIMRSLLEAVTYLHSNNIVHRDLKPENILMDDCLNIKLSDFGFSCILKPTEKLRELCGTPGYLAPEILKCSMDETHPGYGREVDLWACGVIMFTLLAGSPPFWHRKQMLMLRMIMDGRFQFGSPEWDDRSSTVKDLICRLLEVCPEKRLTAEQALQHPFFQSHQRD---------------QDTPVKPSYRFRIAAWAALACVRILVRWRRARPVTTQLLMRD-PYGIKGVRRLIDACAFRIYGHWVKKGERQNRAALFQNQPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: xpo5 (exportin 5 [Source:Xenbase;Acc:XB-GENE-5947328]) HSP 1 Score: 368.622 bits (945), Expect = 4.090e-124 Identity = 191/378 (50.53%), Postives = 244/378 (64.55%), Query Frame = 2
Query: 149 EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY KY+PKEIIG G SSTVRRC+ R+T +YAVKII+V SP L R +E+EIL V+ P II L D YES ++FL+F+L +GELFD+L +VTLSEK TR IM + EAVT++HS NIVHRDLKPENIL+DD LNIK++DFG + E+L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVIM+TLL G PPFWHRKQ LMLR IM+ ++ F SPEWDD S KDLI ++L V P +R+ + +AL H FFQ+ + T + P +F+ A R+ R + T M++ PY + +R+LID AF IY HWVKKGE QNRAA+FQ PK
Sbjct: 18 KEFYQKYDPKEIIGRGVSSTVRRCIHRETGRQYAVKIIEVTPERLSPEQLKEVRLSTAKEMEILHHVSNHPSIISLIDSYESSTFIFLVFDLMKRGELFDYLTEKVTLSEKETRCIMRSLLEAVTYLHSNNIVHRDLKPENILMDDCLNIKLSDFGFSCILKPTEKLRELCGTPGYLAPEILKCSMDETHPGYGREVDLWACGVIMFTLLAGSPPFWHRKQMLMLRMIMDGRFQFGSPEWDDRSSTVKDLICRLLEVCPEKRLTAEQALQHPFFQSHQRD---------------QDTPVKPSYRFRIAAWAALACVRILVRWRRARPVTTQLLMRD-PYGIKGVRRLIDACAFRIYGHWVKKGERQNRAALFQNQPK 379
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: xpo5 (exportin 5 [Source:Xenbase;Acc:XB-GENE-5947328]) HSP 1 Score: 368.237 bits (944), Expect = 6.330e-124 Identity = 191/378 (50.53%), Postives = 244/378 (64.55%), Query Frame = 2
Query: 149 EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY KY+PKEIIG G SSTVRRC+ R+T +YAVKII+V SP L R +E+EIL V+ P II L D YES ++FL+F+L +GELFD+L +VTLSEK TR IM + EAVT++HS NIVHRDLKPENIL+DD LNIK++DFG + E+L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVIM+TLL G PPFWHRKQ LMLR IM+ ++ F SPEWDD S KDLI ++L V P +R+ + +AL H FFQ+ + T + P +F+ A R+ R + T M++ PY + +R+LID AF IY HWVKKGE QNRAA+FQ PK
Sbjct: 18 KEFYQKYDPKEIIGRGVSSTVRRCIHRETGRQYAVKIIEVTPERLSPEQLKEVRLSTAKEMEILHHVSNHPSIISLIDSYESSTFIFLVFDLMKRGELFDYLTEKVTLSEKETRCIMRSLLEAVTYLHSNNIVHRDLKPENILMDDCLNIKLSDFGFSCILKPTEKLRELCGTPGYLAPEILKCSMDETHPGYGREVDLWACGVIMFTLLAGSPPFWHRKQMLMLRMIMDGRFQFGSPEWDDRSSTVKDLICRLLEVCPEKRLTAEQALQHPFFQSHQR---------------DQDTPVKPSYRFRIAAWAALACVRILVRWRRARPVTTQLLMRD-PYGIKGVRRLIDACAFRIYGHWVKKGERQNRAALFQNQPK 379
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Phkg2 (phosphorylase kinase, gamma 2 (testis) [Source:MGI Symbol;Acc:MGI:1916211]) HSP 1 Score: 373.629 bits (958), Expect = 3.630e-126 Identity = 188/381 (49.34%), Postives = 252/381 (66.14%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNS---GVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKR 1276
+ FY KY+PK+IIG G SS VRRC+ R T E+AVKI++V++ ++ +R RE+ ILR VAG P+II L D YES +MFL+F+L KGELFD+L +V LSEK TR IM + EAV+F+H+ NIVHRDLKPENILLDDN+ I+++DFG + + E+L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVI++TLL G PPFWHR+Q LMLR IME +Y F SPEWDD S KDLI K+L V+P R+ + +AL H FF+ E ++ + PR++F+ V + +++ R RL +T + +PY R +R+LID AF +Y HWVKKGE+QNRAA+FQ P R
Sbjct: 17 AKEFYQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDRSNTVKDLISKLLQVDPEARLTAEQALQHPFFERCEGSQPWN---------------LTPRQRFR--VAVWTILAAGRVALSSHRLRPLTKNALLRDPYALRPVRRLIDNCAFRLYGHWVKKGEQQNRAALFQHQPPR 380
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Phkg2 (phosphorylase kinase, gamma 2 (testis) [Source:MGI Symbol;Acc:MGI:1916211]) HSP 1 Score: 373.629 bits (958), Expect = 3.630e-126 Identity = 188/381 (49.34%), Postives = 252/381 (66.14%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNS---GVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKR 1276
+ FY KY+PK+IIG G SS VRRC+ R T E+AVKI++V++ ++ +R RE+ ILR VAG P+II L D YES +MFL+F+L KGELFD+L +V LSEK TR IM + EAV+F+H+ NIVHRDLKPENILLDDN+ I+++DFG + + E+L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVI++TLL G PPFWHR+Q LMLR IME +Y F SPEWDD S KDLI K+L V+P R+ + +AL H FF+ E ++ + PR++F+ V + +++ R RL +T + +PY R +R+LID AF +Y HWVKKGE+QNRAA+FQ P R
Sbjct: 17 AKEFYQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDRSNTVKDLISKLLQVDPEARLTAEQALQHPFFERCEGSQPWN---------------LTPRQRFR--VAVWTILAAGRVALSSHRLRPLTKNALLRDPYALRPVRRLIDNCAFRLYGHWVKKGEQQNRAALFQHQPPR 380
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Phkg1 (phosphorylase kinase gamma 1 [Source:MGI Symbol;Acc:MGI:97579]) HSP 1 Score: 366.311 bits (939), Expect = 1.792e-123 Identity = 190/384 (49.48%), Postives = 248/384 (64.58%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSG----VDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFK----SVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY YEPKEI+G G SS VRRC+ + T EYAVKIID+ G + LR +EV+IL+ V+G P II+L D YE+ + FL+F+L +GELFD+L +VTL+EK TR IM + E + +H NIVHRDLKPENILLDDN+NIK+TDFG + + E+L+E+ GTP YLAPE + +D P YG+ VD+W+ GVIMYTLL G PPFWHRKQ LMLR IM+ KY F SPEWDD S KDL+ + L+V P R + EAL H FF QE V+ ++ FS PR KFK +V+ + ++ + R++ R ++ +PY R LR+LID AF IY HWVKKG++QNRAA+F+ TPK
Sbjct: 13 AQTFYENYEPKEILGRGVSSVVRRCIHKPTCQEYAVKIIDITGGGSFSSEEVQELREATLKEVDILQKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLTEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCSMDDGHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYSDTVKDLVSRFLVVQPQDRCSAEEALAHPFF--QEYVVE---EVRHFS----------PRGKFKVICLTVLASVKIYYQYRRVKPVTREIVI-----RDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Camk2d (calcium/calmodulin-dependent protein kinase II, delta [Source:MGI Symbol;Acc:MGI:1341265]) HSP 1 Score: 229.95 bits (585), Expect = 8.873e-71 Identity = 133/327 (40.67%), Postives = 176/327 (53.82%), Query Frame = 2
Query: 131 TSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN--SGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILL---DDNLNIKITDFGLAVKTDNLEELK-EIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISR 1093
S C F +Y+ E +G GA S VRRCM T EYA KII+ S D + RE I RL+ P I+ LHD E + +L+F+L GELF+ + AR SE + QI E+V H IVHRDLKPEN+LL +K+ DFGLA++ ++ GTPGYL+PE L + PYG+PVD+WACGVI+Y LLVG PPFW QH + +QI Y F SPEWD ++ KDLI K+L +NP +RI +SEAL H + + V ++ +T N RRK K ++ L +R
Sbjct: 2 ASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKL-----EREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL------RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTV----ASMMHRQETVDCLKKFNARRKLKGAILTTMLATR 312
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Camk2d (calcium/calmodulin-dependent protein kinase II, delta [Source:MGI Symbol;Acc:MGI:1341265]) HSP 1 Score: 229.95 bits (585), Expect = 2.024e-69 Identity = 134/329 (40.73%), Postives = 176/329 (53.50%), Query Frame = 2
Query: 131 TSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECH----REVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILL---DDNLNIKITDFGLAVKTDNLEELK-EIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISR 1093
S C F +Y+ E +G GA S VRRCM T EYA KII+ L A H RE I RL+ P I+ LHD E + +L+F+L GELF+ + AR SE + QI E+V H IVHRDLKPEN+LL +K+ DFGLA++ ++ GTPGYL+PE L + PYG+PVD+WACGVI+Y LLVG PPFW QH + +QI Y F SPEWD ++ KDLI K+L +NP +RI +SEAL H + + V ++ +T N RRK K ++ L +R
Sbjct: 2 ASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK-------LSARDHQKLEREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL------RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTV----ASMMHRQETVDCLKKFNARRKLKGAILTTMLATR 312
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P00518|PHKG1_RABIT (Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform OS=Oryctolagus cuniculus OX=9986 GN=PHKG1 PE=1 SV=2) HSP 1 Score: 375.17 bits (962), Expect = 4.090e-126 Identity = 199/400 (49.75%), Postives = 250/400 (62.50%), Query Frame = 2
Query: 95 VNSDMTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSG----VDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ D L G T FY YEPKEI+G G SS VRRC+ + T EYAVKIIDV G + LR +EV+ILR V+G P II+L D YE+ + FL+F+L KGELFD+L +VTLSEK TR IM + E + +H NIVHRDLKPENILLDD++NIK+TDFG + + D E+L+E+ GTP YLAPE + NDN P YG+ VD+W+ GVIMYTLL G PPFWHRKQ LMLR IM Y F SPEWDD S KDL+ + L+V P +R + EAL H FFQ +V V +PR KFK VI +++ +R + R+ +T + +PY R LR+LID AF IY HWVKKG++QNRAA+F+ TPK
Sbjct: 1 MTRDAALPGSHST-----HGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQY-----------------VVEEVRHFSPRGKFK--VICLTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPK 376
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9DB30|PHKG2_MOUSE (Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Mus musculus OX=10090 GN=Phkg2 PE=2 SV=2) HSP 1 Score: 373.629 bits (958), Expect = 2.539e-125 Identity = 188/381 (49.34%), Postives = 252/381 (66.14%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNS---GVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKR 1276
+ FY KY+PK+IIG G SS VRRC+ R T E+AVKI++V++ ++ +R RE+ ILR VAG P+II L D YES +MFL+F+L KGELFD+L +V LSEK TR IM + EAV+F+H+ NIVHRDLKPENILLDDN+ I+++DFG + + E+L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVI++TLL G PPFWHR+Q LMLR IME +Y F SPEWDD S KDLI K+L V+P R+ + +AL H FF+ E ++ + PR++F+ V + +++ R RL +T + +PY R +R+LID AF +Y HWVKKGE+QNRAA+FQ P R
Sbjct: 17 AKEFYQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDRSNTVKDLISKLLQVDPEARLTAEQALQHPFFERCEGSQPWN---------------LTPRQRFR--VAVWTILAAGRVALSSHRLRPLTKNALLRDPYALRPVRRLIDNCAFRLYGHWVKKGEQQNRAALFQHQPPR 380
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P31325|PHKG2_RAT (Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Rattus norvegicus OX=10116 GN=Phkg2 PE=1 SV=1) HSP 1 Score: 373.244 bits (957), Expect = 4.563e-125 Identity = 198/419 (47.26%), Postives = 268/419 (63.96%), Query Frame = 2
Query: 107 MTLS-GDDDTSKKYC--EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNS---GVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRD-KIGHDNLQNDQEYLREIKVS 1339
MTL G +D + + FY KY+PK+IIG G SS VRRC+ R T E+AVKI++V++ ++ +R RE+ ILR VAG P+II L D YES +MFL+F+L KGELFD+L +V LSEK TR IM + EAV F+H NIVHRDLKPENILLDDN+ I+++DFG + + E+L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVI++TLL G PPFWHR+Q LMLR IME +Y F SPEWDD S KDLI K+L V+PN R+ + +AL H FF+ + ++ + PR++F+ V + +++ R RL +T + +PY R +R+LID AF +Y HWVKKGE+QNRAA+FQ P R I +L+ D + E +V+
Sbjct: 1 MTLDVGPEDELPDWAAAKEFYQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVNFLHVNNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSNTVKDLIAKLLQVDPNARLTAEQALQHPFFERCKGSQPWN---------------LTPRQRFR--VAVWTILAAGRVALSSHRLRPLTKNALLRDPYALRPVRRLIDNCAFRLYGHWVKKGEQQNRAALFQHQPPRPFPIIATDLEGDSSAITEDEVT 402
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q16816|PHKG1_HUMAN (Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform OS=Homo sapiens OX=9606 GN=PHKG1 PE=2 SV=3) HSP 1 Score: 372.474 bits (955), Expect = 5.086e-125 Identity = 195/381 (51.18%), Postives = 249/381 (65.35%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVD-SPNI---LRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY YEPKEI+G G SS VRRC+ + T EYAVK+IDV G SP LR +EV+ILR V+G P II+L D YE+ + FL+F+L +GELFD+L +VTLSEK TR IM + E + +H NIVHRDLKPENILLDDN+NIK+TDFG + + + E L+E+ GTP YLAPE + N++ P YG+ VD+W+ GVIMYTLL G PPFWHRKQ LMLR IM Y F SPEWDD S KDL+ + L+V P R + EAL H FFQ L+ ++ + FS PR KFK VIA +++ +R + R+ +T + +PY R LR+LID AF IY HWVKKG++QNRAA+F+ TPK
Sbjct: 13 AQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQ---QYLVEEV--RHFS----------PRGKFK--VIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPK 376
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q2KJ16|PHKG2_BOVIN (Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Bos taurus OX=9913 GN=PHKG2 PE=2 SV=1) HSP 1 Score: 371.703 bits (953), Expect = 1.573e-124 Identity = 186/376 (49.47%), Postives = 250/376 (66.49%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQ 1261
+ FY KY+PK++IG G SS VRRC+ R T E+AVKI++V + SP L R RE ILR VAG P+II L D YES +MFL+F+L KGELFD+L +V LSEK TR IM + EAV+F+H+ NIVHRDLKPENILLDDN+ I+++DFG + + E+L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVI++TLL G PPFWHR+Q LMLR IME +Y F SPEWDD S KDLI ++L V+P +R+ + +AL H FF+ E ++ + PR++F+ V + +++ R R+ +T + + +PY R +R+LID AF +Y HWVKKGE+QNRAA+FQ
Sbjct: 17 AKEFYQKYDPKDVIGRGVSSVVRRCVHRATGQEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHNNNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSDTVKDLISRLLQVDPVERLTAEQALQHPFFERCEGSQAWN---------------LTPRQRFR--VAVWTVLAAGRVALSAHRIRPLTKSALLRDPYALRPVRRLIDNCAFRLYGHWVKKGEQQNRAALFQ 375
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A4E0RBB4 (Phosphorylase kinase gamma subunit OS=Fasciola hepatica OX=6192 GN=D915_004689 PE=3 SV=1) HSP 1 Score: 491.5 bits (1264), Expect = 7.889e-169 Identity = 234/387 (60.47%), Postives = 302/387 (78.04%), Query Frame = 2
Query: 128 DTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHL-CGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKI 1285
DTS + FYSKYE K+I+G+GASSTVRRC++++++ E+AVKI+D+NSGVD+P+I+R+EC REV ILR VAG P IIELHD +E + Y+FL+FE+C GELFD+L +VT+SEKRTR M Q+F+AV+FIHSK+IVHRDLKPENILLDD+LNIK+TDFGLAV D+ +EL+E RGTPGYLAPE L VGY ++QP YGQPVD+WACGVIMYTLLVGCPPFW+RK+HLMLRQIME +YSF SPEWDDIS+ KDLI+++L+V+ + RI +++AL HEFF TQ+ L + S + RRK + +IA + I LR + G L I ++ +PY NR LRK+ID +++D+YS WVKKGEEQNRAA+F+ P+RD I
Sbjct: 14 DTS--LAKSFYSKYEVKDILGSGASSTVRRCIEKQSQREFAVKILDLNSGVDAPDIIRSECMREVSILRRVAGHPNIIELHDVFEGDAYIFLVFEVCTGGELFDYLTHKVTVSEKRTRAFMRQLFDAVSFIHSKHIVHRDLKPENILLDDDLNIKLTDFGLAVFADDEDELRETRGTPGYLAPEVLKVGYYEDQPAYGQPVDIWACGVIMYTLLVGCPPFWNRKEHLMLRQIMEGRYSFPSPEWDDISETTKDLIRRLLVVDSSARITAADALKHEFF-TQQQALPF-------------SRAFDARRKLRVALIAVRFIFCLRSLRTRSGYLQI--DQLAVDPYANRKLRKIIDALSYDVYSQWVKKGEEQNRAALFENAPRRDLI 382
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A4S2MF65 (Protein kinase domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_001389 PE=3 SV=1) HSP 1 Score: 484.952 bits (1247), Expect = 2.946e-166 Identity = 234/400 (58.50%), Postives = 299/400 (74.75%), Query Frame = 2
Query: 128 DTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIG--HDNLQNDQEYL 1321
DTS FY+KYE +I+G+GASSTVRRC+++KTK E+AVKIID+NSGVD P+++R+EC REV ILR VAG P II LHD +E + Y+FL+FE+C GELFD+L +VT+SEKRTR+ M Q+F+AV FIH + IVHRDLKPENILLD NIK+TDFGLAV T++ EEL+E RGTPGYLAPE L VGY ++QPPYGQPVD+WACGVIMYTLL GCPPFW+RK+HLMLRQIME +YSF SPEWDDIS+ KDLI+++L+V+ N RIKS EAL H+FF QT V + + R KF+ ++A + I RLR + G + ++ +PY NR LRK+IDT+++D+YS WVKKGE+QNRAA+F+ P+RD I + + D E+L
Sbjct: 12 DTS--LARSFYAKYEVLDILGSGASSTVRRCVEKKTKEEFAVKIIDLNSGVDLPDVIRSECMREVSILRRVAGHPNIIGLHDVFEGDAYIFLVFEVCRGGELFDYLTHKVTVSEKRTRIFMRQLFDAVDFIHKRRIVHRDLKPENILLDSRENIKLTDFGLAVFTEDKEELRETRGTPGYLAPEVLMVGYYEDQPPYGQPVDMWACGVIMYTLLAGCPPFWNRKEHLMLRQIMEGRYSFPSPEWDDISETAKDLIRRLLVVDTNNRIKSEEALRHDFF---------------VQQTLAVPSGFDARHKFRVGIMAVRFIQRLRDLRTRGGYL-HIKQLAVDPYANRKLRKIIDTLSYDVYSQWVKKGEDQNRAAMFENVPRRDLIEPVSKDEEEDDEFL 393
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0X3PEF4 (Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform OS=Schistocephalus solidus OX=70667 GN=PHKG1 PE=3 SV=1) HSP 1 Score: 482.256 bits (1240), Expect = 3.566e-165 Identity = 224/377 (59.42%), Postives = 289/377 (76.66%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKI 1285
FY+KY P+EI+GTGASSTVRRC+ ++TK E+AVKI+D+NSGVD+ +LRAEC REV IL+ +AG P II+L D + E Y+FL+FELC GELFD+L VTLSEKRTR+IM Q+ +AV+FIHSK IVHRDLKPENILLD ++NIK+ DFGLAV +EL+E RGTPGYLAPE L GY DNQPPYGQPVD+WACGVIMYTLLVG PPFW+RK++LMLRQIM+ YSF SPEWD+IS++ KDLI+K+L+V RIK EAL HEFF S ++ ST+ N +R+F++ +A + I LR++ CG + Y ++ ++PY N+ LRKLIDT+A+D+YSHW+K+G+EQNRAA+F+ P R+ +
Sbjct: 20 FYAKYIPQEILGTGASSTVRRCICKETKEEFAVKILDLNSGVDTSAVLRAECMREVSILKAIAGHPNIIKLQDVFVGEAYVFLVFELCKSGELFDYLTKMVTLSEKRTRMIMRQMLDAVSFIHSKGIVHRDLKPENILLDQDMNIKLADFGLAVFITEKDELQETRGTPGYLAPEVLRCGYYDNQPPYGQPVDIWACGVIMYTLLVGVPPFWNRKEYLMLRQIMQGNYSFPSPEWDEISESAKDLIRKMLVVESTSRIKPREALSHEFF--------------SQGISTPASTLFNAKRRFRAAYVAVRFIHLLRELKACGTSLSIY-KLTSDPYANKRLRKLIDTLAYDVYSHWIKRGDEQNRAALFENQPHRELV 381
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A074ZBD6 (Protein kinase domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_09098 PE=3 SV=1) HSP 1 Score: 481.485 bits (1238), Expect = 6.276e-165 Identity = 229/386 (59.33%), Postives = 293/386 (75.91%), Query Frame = 2
Query: 128 DTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKI 1285
DTS + FY+KYE +I+G+GASSTVRRC+++KTK E+AVKIID+NSGVD P+++R+EC REV ILR V+G P II LHD +E + Y+FL+FE+C GELFD+L +VT+SEKRTR+ M Q+F+AV FIH + IVHRDLKPENILLD NIK+TDFGLAV TD+ EEL+E RGTPGYLAPE L VGY ++QPPYGQPVD+WACGVIMYTLL GCPPFW+RK+HLMLRQIME +YSF SPEWDDIS+ KDLI+++L+V+ N RIKS EAL H+FF QT V + + R KF+ ++A + I LR + G + ++ +PY NR LRK+IDT+++D+YS WVKKGE+QNRAA+F+ P+RD +
Sbjct: 14 DTS--LAQSFYAKYEVLDILGSGASSTVRRCVEKKTKEEFAVKIIDLNSGVDLPDVIRSECMREVSILRRVSGHPNIIGLHDVFEGDAYIFLVFEVCRGGELFDYLTHKVTVSEKRTRIFMRQLFDAVDFIHKRRIVHRDLKPENILLDSRENIKLTDFGLAVFTDDKEELRETRGTPGYLAPEVLMVGYYEDQPPYGQPVDMWACGVIMYTLLAGCPPFWNRKEHLMLRQIMEGRYSFPSPEWDDISETAKDLIRRLLVVDTNNRIKSEEALRHDFF---------------VQQTLAVPSGFDARHKFRVGILAVRFIHCLRDLRTRGGYL-HIKQLAVDPYANRKLRKIIDTLSYDVYSQWVKKGEDQNRAAMFENVPRRDLV 381
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A3R7D6H9 (Phosphorylase b kinase gamma catalytic chain OS=Clonorchis sinensis OX=79923 GN=PHKG1 PE=3 SV=1) HSP 1 Score: 480.715 bits (1236), Expect = 1.407e-164 Identity = 233/400 (58.25%), Postives = 299/400 (74.75%), Query Frame = 2
Query: 128 DTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIG--HDNLQNDQEYL 1321
DTS + FY+KYE +I+G+GASSTVRRC+++KTK E+AVKIID+NSGVD P+++R+EC REV ILR VAG P II LHD +E + Y+FL+FE+C GELFD+L +VT+SEKRTR+ M Q+F+AV FIH + IVHRDLKPENILLD NIK+TDFGLAV T++ EEL+E RGTPGYLAPE L VGY ++QPPYGQPVD+WACGVIMYTLL GCPPFW+RK+HLMLRQIME +YSF SPEWDDIS+ KDLI+++L+V+ N RIKS EAL H+FF QT V + + R KF+ ++A + I LR + G + ++ +PY NR LRK+IDT+++D+YS WVKKGE+QNRAA+F+ P+RD I + + D E+L
Sbjct: 14 DTS--LAQSFYAKYEVLDILGSGASSTVRRCVEKKTKEEFAVKIIDLNSGVDLPDVIRSECMREVSILRRVAGHPNIIGLHDVFEGDAYIFLVFEVCRGGELFDYLTHKVTVSEKRTRIFMRQLFDAVDFIHKRRIVHRDLKPENILLDSRENIKLTDFGLAVFTEDNEELRETRGTPGYLAPEVLMVGYYEDQPPYGQPVDMWACGVIMYTLLAGCPPFWNRKEHLMLRQIMEGRYSFPSPEWDDISETAKDLIRRLLVVDTNNRIKSEEALKHDFF---------------VQQTLTVPSGFDARHKFRVGIMAVRFIHCLRDLRTRGGYL-HIKQLAVDPYANRKLRKIIDTLSYDVYSQWVKKGEDQNRAAMFENVPRRDLIEPVSKDEEEDDEFL 395
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: phkg1b (phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [Source:NCBI gene;Acc:103023937]) HSP 1 Score: 374.4 bits (960), Expect = 1.077e-126 Identity = 195/380 (51.32%), Postives = 256/380 (67.37%), Query Frame = 2
Query: 149 EHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN-SGVDSPNILRA---ECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY+KYEPKEI+G G SS VRRC++++T EYAVKIID+ S +P ++ +E++ILR V+GQ II+L D +ES+ + FLIF+L KGELFD+L +VTLSEK TR IM + + V F+HS NIVHRDLKPENILLDD++NIK+TDFG +V+ + ++L E+ GTPGYLAPE + + N P YG VD+W+ GVIMYTLL G PPFWHRKQ LMLR I+ KY F SPEWDD S KDLI ++L+V+P R ++EAL H FFQ E ++ FS P RKFK VI +++ +R R +T ++++PY + LRK+ID AF IY HWVKKG+ QNRAA+F+ TPK
Sbjct: 14 QEFYNKYEPKEILGRGVSSVVRRCVEKRTNQEYAVKIIDITPSDKMTPEEIKEIQEATVKEIDILRKVSGQKNIIQLKDCFESKAFFFLIFDLMKKGELFDYLTEKVTLSEKETRKIMHALLDVVQFLHSHNIVHRDLKPENILLDDDMNIKLTDFGFSVQIERGQKLNEVCGTPGYLAPEIIECSMDPNHPGYGPAVDLWSSGVIMYTLLAGSPPFWHRKQMLMLRIILAGKYDFSSPEWDDRSDTVKDLISRLLVVDPQSRYTATEALNHPFFQQYEVT-----EVRHFS----------PYRKFK--VICLTVLASMRIYCNYRRAKPVTKEVIRSDPYAIKPLRKMIDACAFKIYGHWVKKGQTQNRAALFENTPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: phkg1a (phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [Source:NCBI gene;Acc:103046290]) HSP 1 Score: 362.844 bits (930), Expect = 4.361e-122 Identity = 187/383 (48.83%), Postives = 251/383 (65.54%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN-SGVDSP---NILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTV--INPRRKFKSVVIAYQLISRLRKMHLCGRLM-ITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY KY+PK+I+G G SS VRRC++++T EYAVKIID+ S +P +R +E+ IL+ V G II+L D YE++ + FL+F+L +GELFD+L +VTLSEK R IM + E V ++HS+NIVHRDLKPENILLDDN+NIK+TDFG +V+ ++L E+ GTPGYLAPE + + + P YG VD+W+ GVIMYTLL G PPFWHRKQ LMLR I+ Y F SPEWDD S KDLI ++L+VN QR +++AL H FFQ +V+ V +P +KFK VI+ +++ +R R +T +K++PY + +RKLID AF IY HWVKKG+ QNRAA+F+ TPK
Sbjct: 13 AQEFYDKYDPKDILGRGVSSVVRRCINKRTTQEYAVKIIDITPSDKMTPAEIEEIRVATLKEINILKKVCGHENIIQLKDCYETKAFFFLVFDLMKRGELFDYLTEKVTLSEKEARKIMRALLEVVQYLHSQNIVHRDLKPENILLDDNMNIKLTDFGFSVQIAPGQKLNEVCGTPGYLAPEIIECSMDPHHPGYGTAVDIWSAGVIMYTLLAGSPPFWHRKQMLMLRMILAGNYQFTSPEWDDRSDTVKDLISRMLVVNAEQRYTATDALNHPFFQQY-----------------VVAEVRHFSPYKKFK--VISLTVLASMRIYCNYRRAKPVTKEVIKSDPYAVKPIRKLIDACAFKIYGHWVKKGQTQNRAALFENTPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: phkg2 (phosphorylase kinase catalytic subunit gamma 2 [Source:NCBI gene;Acc:103041098]) HSP 1 Score: 359.762 bits (922), Expect = 4.393e-121 Identity = 185/401 (46.13%), Postives = 259/401 (64.59%), Query Frame = 2
Query: 119 GDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNS---GVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQ--TQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQN 1306
GD+ + F+ KYEPKE+IG G SS VRRC+++ T E AVK+I++ + V +++ +E+ +L ++ G P II L D YES ++FL+F+L +GELFD+L +VTLSEK TR +M + EAV ++HS NIVHRDLKPENILLDD +IK++DFG +V+ ++L+E+ GTPGYLAPE L ++ YG+ VD+WACGVI++TLL G PPFWHRKQ LMLR IME +Y F SPEWDD S KDLI ++L+V+P R+ + +AL H FF+ +E V L+ +PR+ F+ +++ R+ + R +T + +PY R +RKLID AF IY HWVKKGE+QNRAA+FQ T K +G ++L+N
Sbjct: 7 GDELPDWVGAKEFHQKYEPKEVIGRGVSSVVRRCVNKHTGEELAVKVIEITAEKMTVQQLEEVKSSTLKEIHVLNVLKGHPSIITLVDSYESATFIFLVFDLMRRGELFDYLTEKVTLSEKETRYMMRALLEAVQYLHSLNIVHRDLKPENILLDDQGHIKLSDFGFSVQLRPGQKLRELCGTPGYLAPEILKCSMDETHEGYGKEVDLWACGVILFTLLAGSPPFWHRKQLLMLRMIMEGRYQFSSPEWDDRSDTVKDLISRLLVVDPPLRLTAEQALAHPFFRQYQKEEVRLF-----------------SPRKTFRVLILTVLGCIRMYCRYNRAR-PLTRELLARDPYSLRAVRKLIDGCAFRIYGHWVKKGEQQNRAALFQNTTKILLVGLEDLEN 389
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: phkg2 (phosphorylase kinase catalytic subunit gamma 2 [Source:NCBI gene;Acc:103041098]) HSP 1 Score: 359.762 bits (922), Expect = 4.393e-121 Identity = 185/401 (46.13%), Postives = 259/401 (64.59%), Query Frame = 2
Query: 119 GDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNS---GVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQ--TQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQN 1306
GD+ + F+ KYEPKE+IG G SS VRRC+++ T E AVK+I++ + V +++ +E+ +L ++ G P II L D YES ++FL+F+L +GELFD+L +VTLSEK TR +M + EAV ++HS NIVHRDLKPENILLDD +IK++DFG +V+ ++L+E+ GTPGYLAPE L ++ YG+ VD+WACGVI++TLL G PPFWHRKQ LMLR IME +Y F SPEWDD S KDLI ++L+V+P R+ + +AL H FF+ +E V L+ +PR+ F+ +++ R+ + R +T + +PY R +RKLID AF IY HWVKKGE+QNRAA+FQ T K +G ++L+N
Sbjct: 7 GDELPDWVGAKEFHQKYEPKEVIGRGVSSVVRRCVNKHTGEELAVKVIEITAEKMTVQQLEEVKSSTLKEIHVLNVLKGHPSIITLVDSYESATFIFLVFDLMRRGELFDYLTEKVTLSEKETRYMMRALLEAVQYLHSLNIVHRDLKPENILLDDQGHIKLSDFGFSVQLRPGQKLRELCGTPGYLAPEILKCSMDETHEGYGKEVDLWACGVILFTLLAGSPPFWHRKQLLMLRMIMEGRYQFSSPEWDDRSDTVKDLISRLLVVDPPLRLTAEQALAHPFFRQYQKEEVRLF-----------------SPRKTFRVLILTVLGCIRMYCRYNRAR-PLTRELLARDPYSLRAVRKLIDGCAFRIYGHWVKKGEQQNRAALFQNTTKILLVGLEDLEN 389
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: camk2g2 (calcium/calmodulin dependent protein kinase II gamma [Source:NCBI gene;Acc:103044561]) HSP 1 Score: 229.18 bits (583), Expect = 4.448e-69 Identity = 129/321 (40.19%), Postives = 180/321 (56.07%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECH----REVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEELK-EIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISR 1093
F +Y+ E +G GA S VRRC+ + T EYA KII+ L A H RE I RL+ P I+ LHD E + +L+F+L GELF+ + AR SE ++QI E+V+ IH +IVHRDLKPEN+LL + +K+ DFGLA++ ++ GTPGYL+PE L + PYG+PVD+WACGVI+Y LLVG PPFW QH + +QI Y F SPEWD ++ K+LI ++L +NP +RI + +AL H + + V ++ +T N RRK K ++ L+SR
Sbjct: 10 FTDEYQLYEELGKGAFSVVRRCVKKSTGQEYAAKIINTKK-------LSARDHQKLEREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCINQILESVSHIHQHDIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL------RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTV----ASMMHRQETVECLRKFNARRKLKGAILTTMLVSR 312
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: phkg1b (phosphorylase kinase, gamma 1b (muscle) [Source:ZFIN;Acc:ZDB-GENE-050522-52]) HSP 1 Score: 379.407 bits (973), Expect = 2.848e-129 Identity = 193/398 (48.49%), Postives = 263/398 (66.08%), Query Frame = 2
Query: 95 VNSDMTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILR---AECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDI-NLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMK-NEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ D+ + D T + F KYEPKE++G+G SS VRRC+ ++T ++AVKIID+ S L + +EV+IL+ V+G P+II L D YES + FL+F+L +GELFD+L +V LSEK TR IM IFE V F+H+KNIVHRDLKPENILLDDN+NI+++DFG +++ E L+E+ GTPGYL+PE L +++ P YG+ VD+WACGVIMYTLL G PPFWHRKQ MLR IM+ KY F +PEW+D S KDLI ++L+V P +R + +AL H FFQ YD+ ++ FS P RKFK++++ +++ +R + R+ TE+ +PY R +R+LID AF IY HWVKKGE QNRAA+F+ TPK
Sbjct: 1 MTRDLAIPEGDHTEPVAAQDFNDKYEPKEVLGSGVSSVVRRCVHKRTGQDFAVKIIDITPDRLSEEELEDIYSSTVKEVDILKAVSGHPHIITLIDAYESSTFFFLVFDLMKRGELFDYLTEKVALSEKDTRSIMRSIFEVVHFLHAKNIVHRDLKPENILLDDNMNIRLSDFGFSMQLRPGERLRELCGTPGYLSPELLKCSMDESHPGYGKEVDLWACGVIMYTLLAGSPPFWHRKQMTMLRLIMDGKYDFSTPEWEDRSDTVKDLISRLLVVEPEKRFTAEQALAHPFFQQ------YDVEEVRHFS----------PYRKFKTIMLT--VLASVRMYYHYRRVRPVTTEIVLRDPYALRAVRRLIDGAAFRIYGHWVKKGERQNRAALFENTPK 380
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008748.1 (pep scaffold:Pmarinus_7.0:GL476577:591:63029:-1 gene:ENSPMAG00000007907.1 transcript:ENSPMAT00000008748.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 218.779 bits (556), Expect = 2.419e-67 Identity = 125/322 (38.82%), Postives = 174/322 (54.04%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN--SGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEELK-EIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISR 1093
C F +Y+ E +G GA S VRRC+ T E+A KII+ S D + RE I RL+ I+ LH+ E + +L+F+L GELF+ + AR SE + QI E+V H IVHRDLKPEN+LL + +K+ DFGLA++ ++ GTPGYL+PE L + PYG+PVD+WACGVI+Y LLVG PPFW QH + +QI Y F SPEWD ++ K+LI ++L +NP +RI ++EAL H + + V + +T N RRK K ++ L +R
Sbjct: 7 CTRFTDEYQLYEELGKGAFSVVRRCVKVSTGQEFAAKIINTKKLSARDHQKL-----EREARICRLLK-HSNIVRLHESIAEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVHHCHQHGIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL------RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTAEAKNLINQMLTINPAKRITAAEALKHPWICQRSTV----ASCMHRQETVECLRKFNARRKLKGAILTTMLATR 312
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: camk2a (calcium/calmodulin-dependent protein kinase II alpha [Source:ZFIN;Acc:ZDB-GENE-051113-72]) HSP 1 Score: 174.866 bits (442), Expect = 6.868e-51 Identity = 95/227 (41.85%), Postives = 126/227 (55.51%), Query Frame = 2
Query: 425 GELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEELK-EIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISR 1093
GELF+ + AR SE + QI EAV H IVHRDLKPEN+LL +K+ DFGLA++ ++ GTPGYL+PE L + PYG+PVD+WACGVI+Y LLVG PPFW QH + +QI Y F SPEWD ++ K LI ++L +NP +RI +SEAL H + + V + +T N RRK K ++ L +R
Sbjct: 4 GELFEDIVAREYYSEADASTGIQQILEAVLHCHQLGIVHRDLKPENLLLASKTKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL------RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKSLINQMLTINPAKRITASEALTHPWIFQRSTV----ASCMHRQETVECLKKFNARRKLKGAILTTMLATR 220
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: rps6ka5 (ribosomal protein S6 kinase, polypeptide 5 [Source:ZFIN;Acc:ZDB-GENE-130530-693]) HSP 1 Score: 165.236 bits (417), Expect = 4.676e-46 Identity = 101/286 (35.31%), Postives = 152/286 (53.15%), Query Frame = 2
Query: 155 FYSKYE---PKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLA-VKTDNLEELKEIRGTPGYLAPEALA-VGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHL-------MLRQIMECKYSFHSPEWDDISQAPKDLIK-KILIVNPNQRIKSSEALFHEFFQ 964
F+ YE + +G G+ S RRC +KT E+AVKI+ + A RE+ L+L P I+ + D Y ++ +L+ EL GEL + + R SE IM ++ A +F+H +VHRDLKPEN+L D+ IK+ DFG A +K + LK T Y APE L GY+++ DVW+ GVI+YT+L G PF Q + ++R+I E +SF W ++SQA KDLI+ ++L V+P++R+K S ++E+ Q
Sbjct: 104 FFQHYEMDMKEPPLGEGSFSICRRCKHKKTGQEHAVKIVSKR--------MEANTQREIAALKLCHAHPNIVNIIDVYHDTLHTYLVMELLKGGELLERIKKRSHFSETEASRIMRKLVSATSFMHDTGVVHRDLKPENLLFADDTEGAAIKVIDFGFARLKPQDNAPLKTPCFTLQYAAPELLQHAGYDES-------CDVWSLGVILYTMLSGQVPFQSHGQPMTCSSATDIMRKIKEGDFSFEGEAWQNVSQAAKDLIQGRLLTVDPSKRVKMSGLRYNEWLQ 374
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001278.1 (pep scaffold:Pmarinus_7.0:GL476529:253165:339525:-1 gene:ENSPMAG00000001147.1 transcript:ENSPMAT00000001278.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 154.451 bits (389), Expect = 9.152e-44 Identity = 98/296 (33.11%), Postives = 156/296 (52.70%), Query Frame = 2
Query: 191 TGASSTVRRCMDRKTKIEYAVKIID-VNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDN----LNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPN-QRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFK 1060
+G + V++C ++K+ +E+A K I S ++ + REV ILR + P II LH+ YE++ + LI EL GELFD L + +LSE + QI + V+++H + I H DLKPENI+L +N ++KI DFGLA + E + I GTP ++ PE + N P G D+W+ GV+ Y LL G PF + L I +Y F + S K+ I+++L+ +PN +R+ EA+ H + + ++ L L + ++ S N RRK++
Sbjct: 3 SGQFAVVKKCCEKKSGLEFAAKFIKKRRSRSSRRGVVPEDIKREVSILRELR-HPNIISLHEVYENDTDVTLILELVSGGELFDFLAHKESLSEDEATEFLKQILDGVSYLHCRRIAHFDLKPENIMLLENRAPKAHVKIIDFGLAQSIVDGVEFRHIFGTPEFVVPEIV------NYEPLGVQADMWSIGVMTYILLSGASPFLGDTKEETLSNISAVEYKFDEEYFKQTSALAKNFIQRLLLKSPNRERMNVEEAIHHPWIKPKDKHQLLHRKLSFINLENLKS--FNARRKWR 289
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: GIN4 (Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication [Source:SGD;Acc:S000002915]) HSP 1 Score: 160.999 bits (406), Expect = 6.262e-43 Identity = 99/274 (36.13%), Postives = 146/274 (53.28%), Query Frame = 2
Query: 179 EIIGTGASSTVRRCMDRKTKIEYAVKII--------DVNS----GVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQ 964
E +G G++ V+ + T E AVK+I +V+ G +P+ L RE+ I++L+ P ++ L+D +E+ ++L+ E KGELF+ L R L E QI V++ H+ IVHRDLKPEN+LLD NIKI DFG+A + L+ G+P Y APE ++ P G DVW+CGVI++ LL G PF ++ + K F P D+IS+ +DLI+KIL V+P +RIK+ + L H Q
Sbjct: 23 ETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREIIIMKLL-NHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVS-----GIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTVDPERRIKTRDILKHPLLQ 290
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: DUN1 (Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role [Source:SGD;Acc:S000002259]) HSP 1 Score: 155.606 bits (392), Expect = 2.131e-42 Identity = 100/305 (32.79%), Postives = 155/305 (50.82%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFY-----ESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILL-----------------DDNLNI--KITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLR-QIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFF---QTQENVLL 985
F+ KY + +G G + V+ ++KT + AVKI D + E IL V P I+ L D + +S++ +L+ E GELF+ + + L + ++ + Q+ + ++H +NI+HRD+KPENILL +D ++I KI DFGLA T ++ + GTP Y+APE L + Y VD+W+ GVI+Y L G PPF + L+ QI++ KY+F+SP WD I + LI +L++NP++R EAL H +F Q Q +V L
Sbjct: 196 FFDKYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKK--NKQFREETNILMRVQ-HPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLT------KKGYTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPWFNDIQQQSSVSL 491
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CMK2 (Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005376]) HSP 1 Score: 152.14 bits (383), Expect = 1.247e-41 Identity = 102/320 (31.87%), Postives = 164/320 (51.25%), Query Frame = 2
Query: 185 IGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDD---NLNIKITDFGLAVKTDNLEEL-KEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKY--SFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQL---ISRLRKMHLCG 1117
+G G+ VR+ T + A+KI+ + + N+ + E+ IL+ ++ P I+ D++ES+ +++ +L GELFD + +R +E I+ QI AV ++HSKN+VHRDLKPEN+L D N + I DFG+A + E+L + G+ GY+APE L Q +G+P D+W+ GVI YTLL G PF + + +Y +FH P WD+IS K I K L +NP R ++E L + ++ +++ + V + R+K + + +L I RLR M+ G
Sbjct: 53 LGAGSFGVVRQARKLSTNEDVAIKIL-LKKALQGNNVQLQMLYEELSILQKLS-HPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLT------QDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPWITSKR--------VETSNILPDVKKGFSLRKKLRDAIEIVKLNNRIKRLRNMYSLG 356
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CMK1 (Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication [Source:SGD;Acc:S000001910]) HSP 1 Score: 148.673 bits (374), Expect = 2.980e-40 Identity = 101/325 (31.08%), Postives = 171/325 (52.62%), Query Frame = 2
Query: 164 KYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEE-LKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKY--SFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQL---ISRLRKMHL 1111
KY + +G G VR+ + +T + AVKI+ + + + + E++IL+ + P I+ D++ES+ ++I +L GELFD + + +E+ I+ +I AV ++HS+NIVHRDLKPEN+L D + + + DFG+A + + EE L + G+ GY+APE L Q +G+P D+W+ GVI YTLL G F + L + +Y FH P WD +S K I K L ++P++R ++E L E+ + L++ + + ++ R+KF++ V +L I +LR ++L
Sbjct: 36 KYVFGKTLGAGTFGVVRQAKNTETGEDVAVKIL-IKKALKGNKVQLEALYDELDILQRLH-HPNIVAFKDWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVL------TQDGHGKPCDIWSIGVITYTLLCGYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAELL--------EDPWIICTELKTHNLLPGLKEGLDARQKFRNSVERVRLNMKIQKLRDLYL 344
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KCC4 (Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication [Source:SGD;Acc:S000000529]) HSP 1 Score: 152.14 bits (383), Expect = 5.132e-40 Identity = 95/273 (34.80%), Postives = 146/273 (53.48%), Query Frame = 2
Query: 179 EIIGTGASSTVRRCMDRKTKIEYAVKIIDV----NSG--VDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENV 979
E +G G++ V+ +T AVK+I N+G + ++L RE+ I++L++ P ++ L+D +E+ ++LI E KGELF+ L L E+ QI +++ H+ IVHRDLKPEN+LLD NIKI DFG+A + + L+ G+P Y APE ++ P G DVW+CGVI++ LL G PF ++ + K F P +IS+ +DLI KIL+V+P QRIK + L H + + +
Sbjct: 25 ETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLS-HPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVS-----GLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLLKKYQTI 291
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO44594 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RV77]) HSP 1 Score: 358.607 bits (919), Expect = 4.073e-121 Identity = 190/393 (48.35%), Postives = 250/393 (63.61%), Query Frame = 2
Query: 95 VNSDMTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQE--NVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVK--KGEEQNRAAVFQ 1261
+N D L G + T F KYEPKE++G G SS VR+C D+ T +AVKIID S +I+ A EV IL + G II L D +ES + FL+FE+ PKGELFD+L +VTLSEK+TR IM IFEAV ++H N+VHRDLKPENILLD+ +N+KI+DFG AV+ E L+E+ GTPGYLAPE L + P Y + VD+WACGVI+YTLL G PPFWHR+Q +MLR IM KY+F SPEW+D+S K+LIKK+L+V+P +RI +S+AL H + Q+ + V + QS + R KFK V+A + R+ + L +++ + PY N+ +RKLID AF IY HWVK K E QNRAA+F+
Sbjct: 4 LNFDDGLLGSEATGG-----FIDKYEPKELLGCGVSSIVRKCYDKLTGKAFAVKIIDKLSDQGGSDII-ATTRDEVNILLSLQGHKNIIRLEDVFESTAFFFLVFEIAPKGELFDYLTEKVTLSEKQTRRIMLSIFEAVDYMHYHNVVHRDLKPENILLDEEINVKISDFGFAVELKEGETLRELCGTPGYLAPEVLQCSMFPDAPGYTKEVDMWACGVILYTLLCGFPPFWHRRQVVMLRNIMNGKYNFSSPEWEDVSNDAKNLIKKLLVVHPKERITASDALKHPWLQSTKVRTVSFFLFYFQSQKNDRFCA-----RWKFKGAVLAVIAVQEFRRFIISKILPVSFDIVTEHPYGNKPIRKLIDGCAFRIYGHWVKRNKDENQNRAALFE 385
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO30537 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0H5]) HSP 1 Score: 226.098 bits (575), Expect = 1.369e-68 Identity = 131/326 (40.18%), Postives = 188/326 (57.67%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILL---DDNLNIKITDFGLAVKTDNLEELK--EIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCG 1117
F+ YE KE +G GA S VRRC+ ++++IEYA KII+ + S ++ + + RE I RL+ P I+ LH E Y +L+F+L GELF+ + AR SE + QI E+V H+ N+VHRDLKPEN+LL + N +K+ DFGLA++ + +E+ GTPGYL+PE L + PYG+PVD+WACGVI+Y LLVG PPFW QH + QI Y + SPEWD ++ KDLI +L V+ ++RI + EAL H + +E V ++ Q +T N RRK K ++ L + ++ G
Sbjct: 9 FHDTYELKEELGKGAFSIVRRCIHKESRIEYAAKIINTRK-LSSRDLQKLD--REARICRLLK-HPNIVRLHASIAEEGYHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIIESVQHCHTNNVVHRDLKPENLLLASKEKNAAVKLADFGLAIEVE-IEKTGWYGFAGTPGYLSPEVL------KKEPYGKPVDLWACGVILYILLVGYPPFWDEDQHKLYAQIKTGNYDYPSPEWDTVTDEAKDLINMMLTVDQSKRIGAGEALKHPWIVNRERV-ASKVHRQ---ETLDGLKKFNARRKLKGAILTTILATSNFNTNIAG 319
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49898 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RF52]) HSP 1 Score: 221.476 bits (563), Expect = 7.735e-67 Identity = 133/320 (41.56%), Postives = 182/320 (56.88%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECH---REVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILL---DDNLNIKITDFGLAVKTDNLEELK--EIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLIS 1090
F KYE KE +G GA STVR+C R+TKIEYAVKI+D + N+ + + H RE I R + P ++ LH S+ + FL+F+L GELF+ + AR SE + Q+ +V H IVHRDLKPEN+LL + +K+ DFGLA++ D E L GTPGYL+PE L + PYG+PVD+WACGVI+Y LLVG PPFW +Q + QI Y + SPEWD ++ KDLI K+L V+ +RI ++EAL H + +E + ++ Q QT N RRK + + A L +
Sbjct: 13 FNEKYELKEELGKGAFSTVRKCCHRETKIEYAVKILD------TKNMTQRDVHKVEREARICRHLR-HPNVVRLHANIMSDGFYFLVFDLVTGGELFEDIVAREYYSEADASHCIQQVLLSVQHCHENGIVHRDLKPENLLLASRERGAMVKLADFGLAIEVDG-ERLGWYGFAGTPGYLSPEVL------KKDPYGKPVDLWACGVILYILLVGYPPFWDEEQQKLYSQIKAGTYDYPSPEWDTVTADAKDLIDKMLTVDAPKRITAAEALKHPWIVNRERI-ASKVHRQ---QTLDGLKRFNARRKLRGAIHATILAT 314
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO33022 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STC5]) HSP 1 Score: 202.216 bits (513), Expect = 1.721e-61 Identity = 120/321 (37.38%), Postives = 180/321 (56.07%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN------IKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLR 1099
F YE + IG GA V +C++ +T+ +AVK ID + + + + E +I L+ P I+ L D + + M L+ E P G+LFD + R SEK + Q+ +A+ ++ K I+HRDLKPEN+LL + + IK+TDFG+A ++LK G+P YLAPE + + VD+WACGVI+Y LLVG PPFW+ + +L I++ Y+F SP WD +S+ KDLI+K+L+V+P RI + EAL HE+ +++ +N QS T + T N RRK + VV+ LI+R R
Sbjct: 3 FEDVYEITDFIGKGAFGQVSKCVNLQTREVFAVKEIDFSGSEED----KKKAQNEAKICGLL-DHPSIVHLEDVFFTPRRMLLVLEYLPGGDLFDGVVTRTQFSEKDACACVRQVLKALRYLTRKGIIHRDLKPENLLLSERPSDHRPPIIKLTDFGIA------KQLKG-NGSPLYLAPETIL------EEGLTYAVDIWACGVILYLLLVGYPPFWNEQTEFLLLSILQSNYTFPSPYWDTVSEPAKDLIRKMLVVDPRDRITAVEALKHEWVSGSDDIPGLRLNRQS---TLVRLTAFNARRKLRGVVLG--LIARKR 300
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO41242 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4Z6]) HSP 1 Score: 180.259 bits (456), Expect = 1.552e-53 Identity = 99/274 (36.13%), Postives = 154/274 (56.20%), Query Frame = 2
Query: 167 YEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILL---DDNLNIKITDFGLAVKTDNLEELKE--IRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQE 973
Y+ E+IG G+ + V RC++RKT +E+A K + + D I +E+ + + + + I+ L+ + LI E G LFD + + SEK+ RL+ Q+ A+ ++HS+ IVHRD+KP+N+LL +N+ IK+ DFGLA N ++ G P +LAPE + + P G+ VD+WACGVI Y LLVG PPFW +L I+ +Y+ SP WD++S +DL+ K+++V+P RI + EAL H + E
Sbjct: 5 YDMLELIGEGSFAKVFRCIERKTGLEFAAKELRLTDVEDKEKI-----EQEIAVWKDLRHE-NIVSLYSSIREGETVCLIMEYVAGGSLFDEVIQQTYYSEKQARLVTRQLLNALEYLHSRRIVHRDIKPDNLLLKRTGNNVTIKLADFGLAQALPNDTDVISCGASGAPMFLAPETVL------EEPIGRAVDIWACGVIFYLLLVGYPPFWSNSDEQLLLSILRGQYTMPSPFWDNVSNDARDLVHKLIVVDPEARISAKEALSHPALKENE 266
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: phkg2 (phosphorylase kinase catalytic subunit gamma 2 [Source:NCBI gene;Acc:101165598]) HSP 1 Score: 365.54 bits (937), Expect = 2.657e-123 Identity = 190/405 (46.91%), Postives = 261/405 (64.44%), Query Frame = 2
Query: 119 GDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQ--TQENVLLYDINLQSFSQTSIVSTVINPRRKFK----SVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQN 1306
GD+ + FY KY+PKE+IG G SS VRRC+ R T E AVKII++ + + L ++ +E+ +L +V G P II L D YES ++FL+F+L +GELFD+L +VTLSEK TR IM + EAV ++HS NIVHRDLKPENILLDD+ +IK++DFG +V+ + + L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVI++TLL G PPFWHRKQ LMLR IME +Y F SPEWDD S KDLI ++L+V+ R+ + +AL H FF+ +E+V L+ +PR+ F+ SV+ ++ SR R++ +T + +PY R +RKLID AF IY HWVKKGE+QNRAA+FQ T K +G ++ +
Sbjct: 8 GDELPDWVGAKEFYQKYDPKEVIGRGVSSVVRRCVHRHTGQELAVKIIEITAEKMTAQQLEEVKSSTLKEIHLLNMVKGHPSIITLIDSYESTTFIFLVFDLMRRGELFDYLTEKVTLSEKETRSIMRALLEAVQYLHSLNIVHRDLKPENILLDDHGHIKLSDFGFSVQLEPGKNLRELCGTPGYLAPEILKCSMDEMHPGYGKEVDLWACGVILFTLLAGSPPFWHRKQMLMLRLIMEGRYQFSSPEWDDRSDTVKDLISRLLVVDSAARLTAEQALAHPFFRQYQKEDVRLF-----------------SPRKTFRVLIVSVLACIRMYSRYRRVR-----PLTREVLARDPYSIRGVRKLIDGCAFRIYGHWVKKGEQQNRAALFQNTAKIMLLGLEDFET 390
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: phkg1a (phosphorylase kinase catalytic subunit gamma 1 [Source:NCBI gene;Acc:101167060]) HSP 1 Score: 362.459 bits (929), Expect = 6.067e-122 Identity = 188/381 (49.34%), Postives = 250/381 (65.62%), Query Frame = 2
Query: 146 CEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVN-SGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDIN-LQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPK 1273
+ FY KYEPKEI+G G SS VRRC+D++T EYAVKIID+ S SP + R +E+ IL+ V GQ II+L D YES+ + FL+F+L KGELFD+L +VTLSEK TR IM + E V F+H++NIVHRDLKPENILLDDN+NIK+TDFG AV+ + + L+E+ GTP YLAPE + + + Y VD+W+ GVIMYTLL G PPFWHRKQ LMLR I+ Y F SPEW+D S KDLI ++L+V+P++R +++AL H FF Y +N ++ FS P R+FK + I R+ + + +T ++++PY + +RKLID AF IY HWVKKG+ QNRAA+F+ PK
Sbjct: 13 AKEFYDKYEPKEILGRGVSSVVRRCLDKRTSQEYAVKIIDITPSDKMSPQQIEEIREATVKEIYILKKVCGQENIIQLKDSYESKSFYFLVFDLMRKGELFDYLTEKVTLSEKETRKIMRALLEVVQFLHAQNIVHRDLKPENILLDDNMNIKLTDFGFAVQIEPGQTLREVYGTPVYLAPEIIECSMDASHAGYWTAVDIWSSGVIMYTLLAGSPPFWHRKQMLMLRMILAGNYDFSSPEWEDRSDTVKDLISRMLVVDPSRRFTAADALNHPFFSQ------YVVNEVRQFS----------PYRRFKVICITVLATMRIYCNYRRAK-PVTKEVIQSDPYAVKPIRKLIDACAFKIYGHWVKKGQTQNRAALFENAPK 376
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: phkg2 (phosphorylase kinase catalytic subunit gamma 2 [Source:NCBI gene;Acc:101165598]) HSP 1 Score: 343.969 bits (881), Expect = 4.276e-115 Identity = 179/380 (47.11%), Postives = 246/380 (64.74%), Query Frame = 2
Query: 194 GASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNIL---RAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQ--TQENVLLYDINLQSFSQTSIVSTVINPRRKFK----SVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQN 1306
G SS VRRC+ R T E AVKII++ + + L ++ +E+ +L +V G P II L D YES ++FL+F+L +GELFD+L +VTLSEK TR IM + EAV ++HS NIVHRDLKPENILLDD+ +IK++DFG +V+ + + L+E+ GTPGYLAPE L ++ P YG+ VD+WACGVI++TLL G PPFWHRKQ LMLR IME +Y F SPEWDD S KDLI ++L+V+ R+ + +AL H FF+ +E+V L+ +PR+ F+ SV+ ++ SR R++ +T + +PY R +RKLID AF IY HWVKKGE+QNRAA+FQ T K +G ++ +
Sbjct: 16 GVSSVVRRCVHRHTGQELAVKIIEITAEKMTAQQLEEVKSSTLKEIHLLNMVKGHPSIITLIDSYESTTFIFLVFDLMRRGELFDYLTEKVTLSEKETRSIMRALLEAVQYLHSLNIVHRDLKPENILLDDHGHIKLSDFGFSVQLEPGKNLRELCGTPGYLAPEILKCSMDEMHPGYGKEVDLWACGVILFTLLAGSPPFWHRKQMLMLRLIMEGRYQFSSPEWDDRSDTVKDLISRLLVVDSAARLTAEQALAHPFFRQYQKEDVRLF-----------------SPRKTFRVLIVSVLACIRMYSRYRRVR-----PLTREVLARDPYSIRGVRKLIDGCAFRIYGHWVKKGEQQNRAALFQNTAKIMLLGLEDFET 373
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: camk2g2 (calcium/calmodulin-dependent protein kinase type II subunit gamma [Source:NCBI gene;Acc:101159287]) HSP 1 Score: 229.95 bits (585), Expect = 2.137e-69 Identity = 129/321 (40.19%), Postives = 180/321 (56.07%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECH----REVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEELK-EIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISR 1093
F +Y+ E +G GA S VRRC+ + T EYA KII+ L A H RE I RL+ P I+ LHD E + +L+F+L GELF+ + AR SE +SQI E+++ IH +IVHRDLKPEN+LL + +K+ DFGLA++ ++ GTPGYL+PE L + PYG+PVD+WACGVI+Y LLVG PPFW QH + +QI Y F SPEWD ++ K+LI ++L +NP +RI + +AL H + + V ++ +T N RRK K ++ L+SR
Sbjct: 10 FTDEYQLYEELGKGAFSVVRRCVKKSTSQEYAAKIINTKK-------LSARDHQKLEREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCISQILESISHIHQHDIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL------RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTV----ASMMHRQETVECLRKFNARRKLKGAILTTMLVSR 312
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: camk2g2 (calcium/calmodulin-dependent protein kinase type II subunit gamma [Source:NCBI gene;Acc:101159287]) HSP 1 Score: 229.95 bits (585), Expect = 2.961e-69 Identity = 129/321 (40.19%), Postives = 180/321 (56.07%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECH----REVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLN---IKITDFGLAVKTDNLEELK-EIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISR 1093
F +Y+ E +G GA S VRRC+ + T EYA KII+ L A H RE I RL+ P I+ LHD E + +L+F+L GELF+ + AR SE +SQI E+++ IH +IVHRDLKPEN+LL + +K+ DFGLA++ ++ GTPGYL+PE L + PYG+PVD+WACGVI+Y LLVG PPFW QH + +QI Y F SPEWD ++ K+LI ++L +NP +RI + +AL H + + V ++ +T N RRK K ++ L+SR
Sbjct: 10 FTDEYQLYEELGKGAFSVVRRCVKKSTSQEYAAKIINTKK-------LSARDHQKLEREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCISQILESISHIHQHDIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL------RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTV----ASMMHRQETVECLRKFNARRKLKGAILTTMLVSR 312
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000038340.1 (SMESG000038340.1) HSP 1 Score: 818.92 bits (2114), Expect = 0.000e+0 Identity = 396/412 (96.12%), Postives = 396/412 (96.12%), Query Frame = 2
Query: 107 MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQEYLREIKVSC 1342
MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQ SIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQEYLREIKVSC
Sbjct: 1 MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQ----------------SIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQEYLREIKVSC 396
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000038340.1 (SMESG000038340.1) HSP 1 Score: 786.563 bits (2030), Expect = 0.000e+0 Identity = 382/412 (92.72%), Postives = 382/412 (92.72%), Query Frame = 2
Query: 107 MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQEYLREIKVSC 1342
MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQ SVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQEYLREIKVSC
Sbjct: 1 MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQ------------------------------SVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQEYLREIKVSC 382
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000038340.1 (SMESG000038340.1) HSP 1 Score: 681.019 bits (1756), Expect = 0.000e+0 Identity = 341/412 (82.77%), Postives = 343/412 (83.25%), Query Frame = 2
Query: 107 MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISRLRKMHLCGRLMITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQEYLREIKVSC 1342
MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDL I +I+ RK L RL MITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQEYLREIKVSC
Sbjct: 1 MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDDNLNIKITDFGLAVKTDNLEELKEIRGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDL-----------------------------------------SVVIAYQLISRLRKM-------HLCGRL---------MITYTEMKNEPYLNRNLRKLIDTIAFDIYSHWVKKGEEQNRAAVFQTTPKRDKIGHDNLQNDQEYLREIKVSC 355
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000008997.1 (SMESG000008997.1) HSP 1 Score: 234.572 bits (597), Expect = 7.200e-71 Identity = 130/318 (40.88%), Postives = 185/318 (58.18%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDD---NLNIKITDFGLAVKTDNLEELKEI--RGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISR 1093
F YE KE +G GA S V+RC+ + + +E+A KII+ + S ++ + E RE I RL+ P I+ LHD + + + +L+F+L GELF+ + AR SE M QI E+V + H NI+HRDLKPEN+LL N +K+ DFGLAV+ EE + GTPGYL+PE L + PYG+PVDVWACGVI+Y LLVG PPFW Q+ + QI + + SPEWD ++ K+LI ++L VNP +RI ++EAL H + +E++ ++ QT N RRK K ++ L +R
Sbjct: 8 FSDLYEMKEELGRGAFSIVKRCVQKASNLEFAAKIINTKR-LSSRDMQKLE--REARICRLLK-HPNIVRLHDSIQDDGFHYLVFDLVTGGELFEDIVAREFYSEADASNCMQQILESVNYCHQNNIIHRDLKPENLLLSSKSKNARVKLADFGLAVEMKENEEASWLGFAGTPGYLSPEVL------RKDPYGKPVDVWACGVILYILLVGYPPFWDEDQNRLYAQIKSGLFDYPSPEWDTVTAEAKNLINQMLTVNPTKRITAAEALKHPWIYQREHI----ASMVHRQQTVDCLKKFNARRKLKGAILTTMLATR 311
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000008997.1 (SMESG000008997.1) HSP 1 Score: 234.187 bits (596), Expect = 7.592e-71 Identity = 130/318 (40.88%), Postives = 185/318 (58.18%), Query Frame = 2
Query: 155 FYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKIIDVNSGVDSPNILRAECHREVEILRLVAGQPYIIELHDFYESEVYMFLIFELCPKGELFDHLNARVTLSEKRTRLIMSQIFEAVTFIHSKNIVHRDLKPENILLDD---NLNIKITDFGLAVKTDNLEELKEI--RGTPGYLAPEALAVGYNDNQPPYGQPVDVWACGVIMYTLLVGCPPFWHRKQHLMLRQIMECKYSFHSPEWDDISQAPKDLIKKILIVNPNQRIKSSEALFHEFFQTQENVLLYDINLQSFSQTSIVSTVINPRRKFKSVVIAYQLISR 1093
F YE KE +G GA S V+RC+ + + +E+A KII+ + S ++ + E RE I RL+ P I+ LHD + + + +L+F+L GELF+ + AR SE M QI E+V + H NI+HRDLKPEN+LL N +K+ DFGLAV+ EE + GTPGYL+PE L + PYG+PVDVWACGVI+Y LLVG PPFW Q+ + QI + + SPEWD ++ K+LI ++L VNP +RI ++EAL H + +E++ ++ QT N RRK K ++ L +R
Sbjct: 8 FSDLYEMKEELGRGAFSIVKRCVQKASNLEFAAKIINTKR-LSSRDMQKLE--REARICRLLK-HPNIVRLHDSIQDDGFHYLVFDLVTGGELFEDIVAREFYSEADASNCMQQILESVNYCHQNNIIHRDLKPENLLLSSKSKNARVKLADFGLAVEMKENEEASWLGFAGTPGYLSPEVL------RKDPYGKPVDVWACGVILYILLVGYPPFWDEDQNRLYAQIKSGLFDYPSPEWDTVTAEAKNLINQMLTVNPTKRITAAEALKHPWIYQREHI----ASMVHRQQTVDCLKKFNARRKLKGAILTTMLATR 311 The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30008473 ID=SMED30008473|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1423bpback to top protein sequence of SMED30008473-orf-1 >SMED30008473-orf-1 ID=SMED30008473-orf-1|Name=SMED30008473-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=413bp MTLSGDDDTSKKYCEHFYSKYEPKEIIGTGASSTVRRCMDRKTKIEYAVKback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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