Protein kinase domain-containing protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30008378 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 165.622 bits (418), Expect = 1.892e-43 Identity = 110/357 (30.81%), Postives = 174/357 (48.74%), Query Frame = 1
Query: 475 RYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
RY H++ Y D RTF + G+L + + S++ N E++ L V Q + +L ++ L +++R P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 278 RYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLV------------PSSRSLSTNGENMGLAV------------------------QYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHI 592
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 165.236 bits (417), Expect = 2.594e-43 Identity = 110/357 (30.81%), Postives = 174/357 (48.74%), Query Frame = 1
Query: 475 RYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
RY H++ Y D RTF + G+L + + S++ N E++ L V Q + +L ++ L +++R P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 274 RYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLV------------PSSRSLSTNGENMGLAV------------------------QYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHI 588
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 165.622 bits (418), Expect = 2.646e-43 Identity = 110/357 (30.81%), Postives = 174/357 (48.74%), Query Frame = 1
Query: 475 RYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
RY H++ Y D RTF + G+L + + S++ N E++ L V Q + +L ++ L +++R P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 305 RYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLV------------PSSRSLSTNGENMGLAV------------------------QYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHI 619
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 165.622 bits (418), Expect = 2.863e-43 Identity = 110/357 (30.81%), Postives = 174/357 (48.74%), Query Frame = 1
Query: 475 RYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
RY H++ Y D RTF + G+L + + S++ N E++ L V Q + +L ++ L +++R P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 309 RYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLV------------PSSRSLSTNGENMGLAV------------------------QYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHI 623
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 165.622 bits (418), Expect = 2.863e-43 Identity = 110/357 (30.81%), Postives = 174/357 (48.74%), Query Frame = 1
Query: 475 RYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
RY H++ Y D RTF + G+L + + S++ N E++ L V Q + +L ++ L +++R P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 309 RYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLV------------PSSRSLSTNGENMGLAV------------------------QYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHI 623
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: nsy-1 (Mitogen-activated protein kinase kinase kinase nsy-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21029]) HSP 1 Score: 147.132 bits (370), Expect = 8.766e-37 Identity = 86/235 (36.60%), Postives = 136/235 (57.87%), Query Frame = 1
Query: 820 DFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKF-----EQKFAKENCLYILMEYVPGGSLGSYIRSH-GRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLD-YERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQ--YDCAADIWSFGATVIEMFTGKPPYSEL-GYYAVIFRIGFEK 1494
+ N ++ ++ +G++G+VY ++++++ +KE+ + E+ +EI++ +L H IV++ K + I ME+VPGGSL S +RS G +NE + ++ILE ++YLH L I+HRDIKGDNVL++ Y K+ DF K L LN ++F GT +MAPE+I+ Q Y ADIWSFG T++EM TG+PP+ E+ A +FR+G K
Sbjct: 660 ELSNSNERVVLGKGTYGTVYAARDMDTQRQIVVKEIEV--KYDEEVQPLMEEISLHSTLC-HANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCKRL------AGLNPVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFK 885
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: nsy-1 (Mitogen-activated protein kinase kinase kinase nsy-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21029]) HSP 1 Score: 147.132 bits (370), Expect = 9.129e-37 Identity = 86/235 (36.60%), Postives = 136/235 (57.87%), Query Frame = 1
Query: 820 DFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKF-----EQKFAKENCLYILMEYVPGGSLGSYIRSH-GRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLD-YERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQ--YDCAADIWSFGATVIEMFTGKPPYSEL-GYYAVIFRIGFEK 1494
+ N ++ ++ +G++G+VY ++++++ +KE+ + E+ +EI++ +L H IV++ K + I ME+VPGGSL S +RS G +NE + ++ILE ++YLH L I+HRDIKGDNVL++ Y K+ DF K L LN ++F GT +MAPE+I+ Q Y ADIWSFG T++EM TG+PP+ E+ A +FR+G K
Sbjct: 646 ELSNSNERVVLGKGTYGTVYAARDMDTQRQIVVKEIEV--KYDEEVQPLMEEISLHSTLC-HANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCKRL------AGLNPVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFK 871
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: cst-2 (Caenorhabditis STE20-like kinase [Source:UniProtKB/TrEMBL;Acc:Q304D8]) HSP 1 Score: 139.428 bits (350), Expect = 8.454e-36 Identity = 83/230 (36.09%), Postives = 125/230 (54.35%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEF 1536
+ GS+GSV+K + S A+K++ D EI KEI+I+ +VK+ + K + L+I+MEY GS+ +R+ + L+E+EI ++ L+ +QYLH L IHRDIK N+LL+ + KL DF ++ L +K + +GT WMAPE+I YD ADIWS G T IEM G+PPYS++ IF I + ++ P+ + EF
Sbjct: 41 LGEGSYGSVHKAIHRESGHVLAIKKVP-VDTDLQEI---IKEISIMQQCKSK-YVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAK------RNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEF 259
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: cst-1 (Serine/threonine-protein kinase cst-1 Serine/threonine-protein kinase cst-1 37kDa subunit Serine/threonine-protein kinase cst-1 18kDa subunit [Source:UniProtKB/Swiss-Prot;Acc:Q9NB31]) HSP 1 Score: 139.813 bits (351), Expect = 1.808e-35 Identity = 83/230 (36.09%), Postives = 125/230 (54.35%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEF 1536
+ GS+GSV+K + S A+K++ D EI KEI+I+ +VK+ + K + L+I+MEY GS+ +R+ + L+E+EI ++ L+ +QYLH L IHRDIK N+LL+ + KL DF ++ L +K + +GT WMAPE+I YD ADIWS G T IEM G+PPYS++ IF I + ++ P+ + EF
Sbjct: 41 LGEGSYGSVHKAIHRESGHVLAIKKVP-VDTDLQEI---IKEISIMQQCKSK-YVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAK------RNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEF 259
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: cst-1 (Serine/threonine-protein kinase cst-1 Serine/threonine-protein kinase cst-1 37kDa subunit Serine/threonine-protein kinase cst-1 18kDa subunit [Source:UniProtKB/Swiss-Prot;Acc:Q9NB31]) HSP 1 Score: 139.813 bits (351), Expect = 2.064e-35 Identity = 83/230 (36.09%), Postives = 125/230 (54.35%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEF 1536
+ GS+GSV+K + S A+K++ D EI KEI+I+ +VK+ + K + L+I+MEY GS+ +R+ + L+E+EI ++ L+ +QYLH L IHRDIK N+LL+ + KL DF ++ L +K + +GT WMAPE+I YD ADIWS G T IEM G+PPYS++ IF I + ++ P+ + EF
Sbjct: 41 LGEGSYGSVHKAIHRESGHVLAIKKVP-VDTDLQEI---IKEISIMQQCKSK-YVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAK------RNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEF 259
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: GckIII (gene:FBgn0266465 transcript:FBtr0083399) HSP 1 Score: 147.902 bits (372), Expect = 1.443e-37 Identity = 86/215 (40.00%), Postives = 121/215 (56.28%), Query Frame = 1
Query: 838 KQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRI 1482
KQ+ I +GSFG V+K + +++ A+K + + + EID +EI +L D P + K+ F K L+I+MEY+ GGS +++ G E I +E+L+ + YLH +HRDIK NVLL + VKL DF ++ L + SK +FVGT WMAPE+I QYD ADIWS G T IE+ G+PP SEL V+F I
Sbjct: 15 KQERIGKGSFGEVFKGIDNRTQQVVAIKIIDL-EEAEDEIDDIQQEIMVLSQC-DSPYVTKYYGSFLKGTKLWIIMEYLGGGSALDLMKA-GSFEEMHIGIILREVLKGLDYLHSERKLHRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSK------RNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLI 220
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Ask1 (gene:FBgn0014006 transcript:FBtr0300256) HSP 1 Score: 147.517 bits (371), Expect = 6.874e-37 Identity = 88/233 (37.77%), Postives = 138/233 (59.23%), Query Frame = 1
Query: 820 DFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSH-GRL--NEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLD-YERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIING--KQYDCAADIWSFGATVIEMFTGKPPYSELG-YYAVIFRIGFEKK 1497
D++ ++ ++ +G++G+VY ++ A+KE+ +++ ++ ++EI + L H IV++ ++ I ME VPGGSL + + G L NE + S++ILE ++YLH I+HRDIKGDNVL++ Y VK+ DF SK L +N ++F GT +MAPE+I+ + Y AADIWSFG T +EM TGKPP+ ELG +A +F++GF KK
Sbjct: 581 DYDEQNRKMVLGKGTYGTVYAARDKQTQVRIAIKEV--PEKNSQDVQPLHEEIKLHSQL-RHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRL------ARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKK 804
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Ask1 (gene:FBgn0014006 transcript:FBtr0083819) HSP 1 Score: 147.517 bits (371), Expect = 7.200e-37 Identity = 88/233 (37.77%), Postives = 138/233 (59.23%), Query Frame = 1
Query: 820 DFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSH-GRL--NEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLD-YERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIING--KQYDCAADIWSFGATVIEMFTGKPPYSELG-YYAVIFRIGFEKK 1497
D++ ++ ++ +G++G+VY ++ A+KE+ +++ ++ ++EI + L H IV++ ++ I ME VPGGSL + + G L NE + S++ILE ++YLH I+HRDIKGDNVL++ Y VK+ DF SK L +N ++F GT +MAPE+I+ + Y AADIWSFG T +EM TGKPP+ ELG +A +F++GF KK
Sbjct: 414 DYDEQNRKMVLGKGTYGTVYAARDKQTQVRIAIKEV--PEKNSQDVQPLHEEIKLHSQL-RHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRL------ARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKK 637
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: hpo (gene:FBgn0261456 transcript:FBtr0331920) HSP 1 Score: 141.354 bits (355), Expect = 3.385e-35 Identity = 86/230 (37.39%), Postives = 118/230 (51.30%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEF 1536
+ GS+GSVYK V S A+K L + EI KEI+I+ D P +V++ + K+ L+I MEY GS+ +R + L E EI + L+ + YLH IHRDIK N+LL+ E + KL DF ++ L +K + +GT WMAPE+I YDC ADIWS G T +EM GKPPY E+ IF I + + P + EF
Sbjct: 48 LGEGSYGSVYKAVHKESSSIVAIK-LVPVESDLHEI---IKEISIMQQC-DSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAK------RNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEF 266
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: hpo (gene:FBgn0261456 transcript:FBtr0086500) HSP 1 Score: 141.354 bits (355), Expect = 3.385e-35 Identity = 86/230 (37.39%), Postives = 118/230 (51.30%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEF 1536
+ GS+GSVYK V S A+K L + EI KEI+I+ D P +V++ + K+ L+I MEY GS+ +R + L E EI + L+ + YLH IHRDIK N+LL+ E + KL DF ++ L +K + +GT WMAPE+I YDC ADIWS G T +EM GKPPY E+ IF I + + P + EF
Sbjct: 48 LGEGSYGSVYKAVHKESSSIVAIK-LVPVESDLHEI---IKEISIMQQC-DSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAK------RNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEF 266
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k22 (mitogen-activated protein kinase kinase kinase 22 [Source:ZFIN;Acc:ZDB-GENE-070928-11]) HSP 1 Score: 160.614 bits (405), Expect = 7.177e-42 Identity = 89/227 (39.21%), Postives = 134/227 (59.03%), Query Frame = 1
Query: 829 NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
N + L+ RG+FG VY C +++ +E A K++ F C + E++ EI +L +L H RIV++ + + L I +E++PGGS+ ++++G L EK R +++IL+ + YLH I+HRDIKG N+L D +VKL DF SK + ++GT KS GT WM+PE+ING+ Y ADIWS TV+EM T KPP++E A IF+I +
Sbjct: 359 NWRQGKLLGRGAFGVVYLCYDVDTGRELAAKQVPFDPECQETSKEVNALECEIQLLKNL-HHERIVQYYGCLRDPVQKKLSIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC----MSGTGIKSVTGTPYWMSPEVINGEGYGRKADIWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQ 580
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1]) HSP 1 Score: 158.688 bits (400), Expect = 3.206e-41 Identity = 90/233 (38.63%), Postives = 134/233 (57.51%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKIL--IHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
L+ +G+FG VY C +++ +E A K++ F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L I +S G +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNL-HHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTG-----VRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQ-PTNPQLPSHI 586
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1]) HSP 1 Score: 158.688 bits (400), Expect = 3.864e-41 Identity = 90/233 (38.63%), Postives = 134/233 (57.51%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKIL--IHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
L+ +G+FG VY C +++ +E A K++ F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L I +S G +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 367 LLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNL-HHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTG-----VRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQ-PTNPQLPSHI 592
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1]) HSP 1 Score: 157.918 bits (398), Expect = 6.007e-41 Identity = 90/233 (38.63%), Postives = 134/233 (57.51%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKIL--IHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
L+ +G+FG VY C +++ +E A K++ F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L I +S G +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 349 LLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNL-HHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTG-----VRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQ-PTNPQLPSHI 574
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96]) HSP 1 Score: 157.532 bits (397), Expect = 7.806e-41 Identity = 88/221 (39.82%), Postives = 131/221 (59.28%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
L+ +G+FG V+ C ++ +E A+K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++S+G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF S+ L L+GT KS GT WM+PE+I+G+ Y ADIWS G TV+EM T +PP++E A IF+I +
Sbjct: 367 LLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLF-HERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTIC----LSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPPWAEFEAMAAIFKIATQ 582
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742]) HSP 1 Score: 168.318 bits (425), Expect = 2.520e-44 Identity = 95/262 (36.26%), Postives = 146/262 (55.73%), Query Frame = 1
Query: 727 IQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKF--AKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
+Q N +L ++ L +++R + P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ E L I MEY+PGGS+ ++++G L E R +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I +
Sbjct: 329 VQYMENRGRLRNADSENTLTVQERNISSKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNL-HHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ 585
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742]) HSP 1 Score: 167.548 bits (423), Expect = 3.701e-44 Identity = 95/262 (36.26%), Postives = 146/262 (55.73%), Query Frame = 1
Query: 727 IQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKF--AKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
+Q N +L ++ L +++R + P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ E L I MEY+PGGS+ ++++G L E R +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I +
Sbjct: 311 VQYMENRGRLRNADSENTLTVQERNISSKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNL-HHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ 567
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570]) HSP 1 Score: 161.77 bits (408), Expect = 3.825e-42 Identity = 93/231 (40.26%), Postives = 138/231 (59.74%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSF---SEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKH 1521
L+ +G+FG VY C ++ +E A+K+++F S E++ EI +L +L H RIV++ + ++E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L L+GT KS GT WM+PE+I+G+ Y ADIWS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 372 LLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKEVNALECEIQLLKNLL-HERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTIC----LSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQ-PTNPQLPAH 596
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570]) HSP 1 Score: 161.384 bits (407), Expect = 4.939e-42 Identity = 93/231 (40.26%), Postives = 138/231 (59.74%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSF---SEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKH 1521
L+ +G+FG VY C ++ +E A+K+++F S E++ EI +L +L H RIV++ + ++E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L L+GT KS GT WM+PE+I+G+ Y ADIWS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 344 LLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKEVNALECEIQLLKNL-LHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTIC----LSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQ-PTNPQLPAH 568
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862]) HSP 1 Score: 155.606 bits (392), Expect = 5.769e-40 Identity = 89/228 (39.04%), Postives = 131/228 (57.46%), Query Frame = 1
Query: 826 ENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
EN L+ RG+FG VY C ++ +E A+K++ F + E++ EI +L L H RIV++ + E L I +EY+PGGS+ ++++G L E R +++IL+ + YLH I+HRDIKG N+L D +VKL DF SK + ++GT KS GT WM+PE+I+G+ Y AD+WS TV+EM T KPP+SE A IF+I +
Sbjct: 352 ENWRLGKLLGRGAFGEVYLCYDVDKGRELAVKQVPFDPDSQETSKEVNALECEIQLL-KLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTIC----MSGTGIKSVTGTPYWMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWSEYEAMAAIFKIATQ 574
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874]) HSP 1 Score: 162.925 bits (411), Expect = 1.094e-42 Identity = 109/357 (30.53%), Postives = 174/357 (48.74%), Query Frame = 1
Query: 475 RYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
RY H++ Y D RTF + G+L + + S++ N E++ + V Q + +L ++ L +++R P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 278 RYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVP------------SSRSLSTNGENMGVAV------------------------QYLDPRGRLRSADSENALTVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHI 592
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873]) HSP 1 Score: 160.999 bits (406), Expect = 6.413e-42 Identity = 89/221 (40.27%), Postives = 133/221 (60.18%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRFCDRS---FSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
L+ +G+FG VY C +++ +E A+K+++F S E++ EI +L +L H RIV++ + +E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D ++KL DF SK L L+GT KS GT WM+PE+I+G+ Y ADIWS TV+EM T KPP++E A IF+I +
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLL-HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTIC----LSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQ 576
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Stk4 (serine/threonine kinase 4 [Source:MGI Symbol;Acc:MGI:1929004]) HSP 1 Score: 154.066 bits (388), Expect = 3.041e-40 Identity = 96/259 (37.07%), Postives = 141/259 (54.44%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQXXXXXXXXXXXXXXXXXXXXXEHPFLKC 1623
+ GS+GSVYK + + + A+K++ S++ KEI+I+ D P +VK+ + K L+I+MEY GS+ IR + L E EI Q L+ ++YLH++ IHRDIK N+LL+ E H KL DF ++ L +K + + +GT WMAPE+I Y+C ADIWS G T IEM GKPPY+++ IF I + P+ + F F+ CL S +R +A LL+HPF+K
Sbjct: 36 LGEGSYGSVYKAIHKETGQIVAIKQVPVE----SDLQEIIKEISIMQQC-DSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRN------TVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVKQCLVKSPEQRATATQLLQHPFVKS 283
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Stk3 (serine/threonine kinase 3 [Source:MGI Symbol;Acc:MGI:1928487]) HSP 1 Score: 152.525 bits (384), Expect = 1.190e-39 Identity = 95/258 (36.82%), Postives = 142/258 (55.04%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQXXXXXXXXXXXXXXXXXXXXXEHPFLK 1620
+ GS+GSV+K + S + A+K++ S++ KEI+I+ D P +VK+ + K L+I+MEY GS+ IR + L E EI + L+ ++YLH++ IHRDIK N+LL+ E H KL DF ++ L +K + + +GT WMAPE+I Y+C ADIWS G T IEM GKPPY+++ IF I + P+ + +F F+ CL S +R +A LL+HPF+K
Sbjct: 31 LGEGSYGSVFKAIHKESGQVVAIKQVPVE----SDLQEIIKEISIMQQC-DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRN------TVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFIK 277
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Stk3 (serine/threonine kinase 3 [Source:MGI Symbol;Acc:MGI:1928487]) HSP 1 Score: 152.14 bits (383), Expect = 1.747e-39 Identity = 95/258 (36.82%), Postives = 142/258 (55.04%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQXXXXXXXXXXXXXXXXXXXXXEHPFLK 1620
+ GS+GSV+K + S + A+K++ S++ KEI+I+ D P +VK+ + K L+I+MEY GS+ IR + L E EI + L+ ++YLH++ IHRDIK N+LL+ E H KL DF ++ L +K + + +GT WMAPE+I Y+C ADIWS G T IEM GKPPY+++ IF I + P+ + +F F+ CL S +R +A LL+HPF+K
Sbjct: 33 LGEGSYGSVFKAIHKESGQVVAIKQVPVE----SDLQEIIKEISIMQQC-DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRN------TVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFIK 279
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q99759|M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2) HSP 1 Score: 165.622 bits (418), Expect = 9.085e-43 Identity = 110/357 (30.81%), Postives = 174/357 (48.74%), Query Frame = 1
Query: 475 RYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
RY H++ Y D RTF + G+L + + S++ N E++ L V Q + +L ++ L +++R P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 278 RYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLV------------PSSRSLSTNGENMGLAV------------------------QYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHI 592
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q61084|M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus OX=10090 GN=Map3k3 PE=1 SV=1) HSP 1 Score: 162.925 bits (411), Expect = 7.652e-42 Identity = 109/357 (30.53%), Postives = 174/357 (48.74%), Query Frame = 1
Query: 475 RYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
RY H++ Y D RTF + G+L + + S++ N E++ + V Q + +L ++ L +++R P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 278 RYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVP------------SSRSLSTNGENMGVAV------------------------QYLDPRGRLRSADSENALTVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHI 592
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9Y2U5|M3K2_HUMAN (Mitogen-activated protein kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP3K2 PE=1 SV=2) HSP 1 Score: 160.999 bits (406), Expect = 4.486e-41 Identity = 89/221 (40.27%), Postives = 133/221 (60.18%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
L+ +G+FG VY C +++ +E A+K+++F + E++ EI +L +L H RIV++ + +E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L L+GT KS GT WM+PE+I+G+ Y ADIWS TV+EM T KPP++E A IF+I +
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLL-HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTIC----LSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQ 576
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q61083|M3K2_MOUSE (Mitogen-activated protein kinase kinase kinase 2 OS=Mus musculus OX=10090 GN=Map3k2 PE=1 SV=2) HSP 1 Score: 156.762 bits (395), Expect = 1.133e-39 Identity = 88/221 (39.82%), Postives = 131/221 (59.28%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRFCDRS---FSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
L+ +G+FG VY C +++ +E A+K+++F S E++ EI +L +L H RIV++ + +E L I ME PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D ++KL DF SK L L+GT KS GT WM+PE+I+G+ Y ADIWS TV+EM T KPP++E A IF+I +
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLL-HERIVQYYGCLRDPQEKTLSIFMELSPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTIC----LSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQ 576
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7ZUQ3|STK3_DANRE (Serine/threonine-protein kinase 3 OS=Danio rerio OX=7955 GN=stk3 PE=2 SV=1) HSP 1 Score: 154.451 bits (389), Expect = 1.448e-39 Identity = 94/257 (36.58%), Postives = 142/257 (55.25%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQXXXXXXXXXXXXXXXXXXXXXEHPFL 1617
+ GS+GSV+K + S + A+K++ S++ KEI+I+ D P +VK+ + K L+I+MEY GS+ IR + L E EI + L+ ++YLH++ IHRDIK N+LL+ E H KL DF ++ L +K + + +GT WMAPE+I Y+C ADIWS G T IEM GKPPY+++ IF I + P+H+ +F F+ CL + +R +A LL+HPF+
Sbjct: 32 LGEGSYGSVFKAIHKESGQVVAIKQVPVE----SDLQEIIKEISIMQQC-DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATVLKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRN------TVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEHWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 277
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: T1G1N2 (Protein kinase domain-containing protein OS=Helobdella robusta OX=6412 GN=20214980 PE=4 SV=1) HSP 1 Score: 165.622 bits (418), Expect = 4.348e-43 Identity = 92/237 (38.82%), Postives = 137/237 (57.81%), Query Frame = 1
Query: 829 NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELR-FCDRS--FSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGS-----LNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVP 1515
N K ++ G FG VY C +++ E A+K++ +C E+ EI +L L + PRIV++ + + L I ME+VPGGS+ I+ +G L E R ++++LE +++LH L I+HRDIKG N+L D+E ++KL DF +K L +K + L G AK+ GT +M+PEII GK+Y DIWS G TV+EM TG PP+ E A IF+I + Y++P
Sbjct: 4 NWKKGKILGAGGFGQVYLCYDVDTGVELAVKQVNVYCQSEDISKEVRALQSEIKLLQDLSN-PRIVQYYGSQKEPHMLSIFMEFVPGGSVKDQIQDYGPLTESVTKRYTKQVLEGLEFLHSLMIVHRDIKGANILRDHEGNIKLTDFGAAKRLSSIVNKTADVSKNLTG-AKTMTGTPYYMSPEIIEGKRYGRKVDIWSLGCTVVEMLTGHPPWHEYEGVAAIFKIATQPHPSYKLP 238
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0C3BRW7 (Protein kinase domain-containing protein (Fragment) OS=Serendipita vermifera MAFF 305830 OX=933852 GN=M408DRAFT_59422 PE=3 SV=1) HSP 1 Score: 164.851 bits (416), Expect = 7.053e-43 Identity = 90/212 (42.45%), Postives = 124/212 (58.49%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSEL-GYYAVIFRI 1482
I RG FG+VY+ + LN+ + A+K + D S EI KE+ +L L HP IVK+E + L I++EYV GSLG IR+ G+LNE+ + +ILE + YLH H++H D+K N+L +VKL DF +S + +HA +L GT NWMAPE+I K A+DIWS G T IE+ TG PPY E+ +V+FRI
Sbjct: 4 IGRGQFGAVYRALNLNTGQMVAVKRIGLQDLSEDEISNLMKEVDVLKRL-SHPSIVKYEGMVRSTDTLSIVLEYVENGSLGQTIRAFGKLNERLVASYITKILEGLHYLHTSHVVHCDLKAANILTTKNGNVKLSDFGVS-LNLHAK---ALEEIKNDVAGTPNWMAPEVIELKGASTASDIWSLGCTAIELLTGHPPYHEIHNGLSVMFRI 210
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A7S4G7 (Predicted protein (Fragment) OS=Nematostella vectensis OX=45351 GN=v1g104385 PE=4 SV=1) HSP 1 Score: 163.696 bits (413), Expect = 1.334e-42 Identity = 90/224 (40.18%), Postives = 130/224 (58.04%), Query Frame = 1
Query: 829 NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKEL---RFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
N K L+ G+FG VY C L++ +E A+K++ + + +E+ EI + + + RIV++ + +YI MEY+PGGS+ +I+ HG LNE + S++ILE I YLH I+HRDIKG N+L D +VKL DF SK L SK +S GT WMAPE+ING+ Y AD+WS G TV+EM T KPP+++ A +F+I +
Sbjct: 3 NWRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEIEFMKAFRNE-RIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRSKTGF----RSVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIATQ 221
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: K1PKP1 (Mitogen-activated protein kinase kinase kinase 2 OS=Crassostrea gigas OX=29159 GN=CGI_10008499 PE=4 SV=1) HSP 1 Score: 162.54 bits (410), Expect = 1.565e-41 Identity = 89/229 (38.86%), Postives = 130/229 (56.77%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRFCD---RSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
L+ G+FG VY C ++ ++ A+K +R + E+ EI +L + +H RIV + + LYI MEY+PGGS+ I +G L E + ++++LE + YLH I+HRDIKG N+L D ++KL DF SK L S L+ S VGT WMAPE+ING+ Y ADIWS G T++EM T KPP++E A +++I EK+ + +P H
Sbjct: 69 LLGSGAFGEVYVCHDKDTGRDLAMKVVRLEQMNAETSKEVRALENEIHLLRNF-EHERIVSYFGCAQDKQSLYIFMEYLPGGSVKDEITKYGSLTENVSRKYTKQMLEGLAYLHKNVIVHRDIKGANILRDGNGNIKLGDFGASKRLQTIVSATGLH----SVVGTPYWMAPEVINGEGYGRKADIWSVGCTIVEMLTTKPPWAEFESMAALYKIAMEKRPHFTLPNHI 292
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A212D6K2 (Protein kinase domain-containing protein (Fragment) OS=Cervus elaphus hippelaphus OX=46360 GN=Celaphus_00001436 PE=4 SV=1) HSP 1 Score: 166.007 bits (419), Expect = 3.176e-41 Identity = 110/357 (30.81%), Postives = 174/357 (48.74%), Query Frame = 1
Query: 475 RYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFE-NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHF 1524
RY H++ Y D RTF + G+L + + S++ N E++ L V Q + +L ++ L +++R P N + L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I + ++P H
Sbjct: 151 RYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVP------------SSRSLSTNGENMGLAV------------------------QYLDPRGRLRSADSENALSVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHI 465
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:ZFIN;Acc:ZDB-GENE-081104-140]) HSP 1 Score: 157.147 bits (396), Expect = 1.637e-43 Identity = 89/237 (37.55%), Postives = 133/237 (56.12%), Query Frame = 1
Query: 838 KQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEI-----DLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKE 1533
K +++ RG++G+VY C + + A+K++ D S SE +E+ +L +L +HP IV F +N + I MEYVPGGS+ S + G L EK ++++LE + YLH +IHRD+KG+N++L VKL DF ++ L G + KS GT WMAPE+IN + +D+WS G TV EM TGKPP + +G A +F IG K ++ +P F +E
Sbjct: 18 KGEVLGRGAYGTVY-CGLTSQGQLIAVKQV-LLDVSTSETAEKEYSRLEREVDLLKNL-EHPNIVGFLGTALTDNVISIFMEYVPGGSISSVLNRFGPLPEKVFALYTRQVLEGVAYLHENRVIHRDLKGNNLMLMPTGVVKLIDFGCARRLNRLTHSGGNSDLLKSVHGTPYWMAPEVINETGHGKKSDVWSIGCTVFEMATGKPPLAHMGKMAALFYIGARKGLMPPLPDDFSEE 251
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3-like [Source:NCBI gene;Acc:103044968]) HSP 1 Score: 158.688 bits (400), Expect = 2.847e-41 Identity = 87/227 (38.33%), Postives = 135/227 (59.47%), Query Frame = 1
Query: 829 NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
N + L+ RG+FG VY C ++ +E A+K++ F C + E++ EI +L +L H RIV++ + ++ L I +E++PGGS+ ++++G L EK R +++IL+ + YLH I+HRDIKG N+L D +VKL DF SK + ++GT K+ GT WM+PE+ING+ Y AD+WS TV+EM T KPP++E A IF+I +
Sbjct: 353 NWRQGKLLGRGAFGEVYLCYDADTGRELAVKQVPFDPECHETSKEVNALECEIQLLKNL-RHERIVQYYGCLRDPEQRKLSIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVFYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC----MSGTGIKTVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQ 574
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3-like [Source:NCBI gene;Acc:103044968]) HSP 1 Score: 158.303 bits (399), Expect = 3.363e-41 Identity = 87/227 (38.33%), Postives = 135/227 (59.47%), Query Frame = 1
Query: 829 NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
N + L+ RG+FG VY C ++ +E A+K++ F C + E++ EI +L +L H RIV++ + ++ L I +E++PGGS+ ++++G L EK R +++IL+ + YLH I+HRDIKG N+L D +VKL DF SK + ++GT K+ GT WM+PE+ING+ Y AD+WS TV+EM T KPP++E A IF+I +
Sbjct: 356 NWRQGKLLGRGAFGEVYLCYDADTGRELAVKQVPFDPECHETSKEVNALECEIQLLKNL-RHERIVQYYGCLRDPEQRKLSIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVFYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC----MSGTGIKTVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQ 577
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596]) HSP 1 Score: 157.918 bits (398), Expect = 5.553e-41 Identity = 88/222 (39.64%), Postives = 130/222 (58.56%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKIL--IHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L I +S G +S GT WM+PE+I+G Y AD+WS G TV+EM T KPP++E A IF+I +
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKNL-HHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTG-----VRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ 576
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596]) HSP 1 Score: 157.918 bits (398), Expect = 5.553e-41 Identity = 88/222 (39.64%), Postives = 130/222 (58.56%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKIL--IHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L I +S G +S GT WM+PE+I+G Y AD+WS G TV+EM T KPP++E A IF+I +
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKNL-HHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTG-----VRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ 576
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96]) HSP 1 Score: 165.236 bits (417), Expect = 2.573e-44 Identity = 90/226 (39.82%), Postives = 135/226 (59.73%), Query Frame = 1
Query: 829 NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSF---SEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
N + L+ +G+FG VY C ++ +E A+K+++F S E++ EI +L +L H RIV++ + ++ L I MEY+PGGS+ +R++G L E + +++ILE + +LH I+HRDIKG N+L D +VKL DF SK L S+G+ +S GT WM+PE+ING+ Y ADIWS G TV+EM T KPP++E A IF+I +
Sbjct: 358 NWQRGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPGSVETSKEVNALECEIQLLKNL-QHERIVQYFGCLRDPQQKTLSIFMEYMPGGSIKDQLRAYGALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGT---AMRSVTGTPYWMSPEVINGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQ 579
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:ZFIN;Acc:ZDB-GENE-081104-140]) HSP 1 Score: 142.895 bits (359), Expect = 8.402e-39 Identity = 83/245 (33.88%), Postives = 127/245 (51.84%), Query Frame = 1
Query: 835 IKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCD----------RSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQ 1539
IK + + +G+FG+V+ + N K A+KEL D + SE+ E+ +L +L HP +V++ + N I ME+VPGG++ +R G L E ++ + YLH ++H D+KG N ++ VKL DF ++ + A S NG S GTA WMAPE+ING Y AD+WS G T+ EM G+PP++++ A + IG I+ +P+ F KE Q
Sbjct: 16 IKGNRLGKGAFGTVFLGLT-NQGKLIAVKELELRDAQSANGNQGGQKQSELQKLQDEVELLTTL-HHPNVVEYLGTEMEGNRFSIFMEFVPGGTVAETVRGFGPLGESVCRSYIAQMTRGLAYLHGHGVMHGDVKGSNAVITPAGVVKLIDFGCAQRVALALSC-HENGGLHSVHGTAYWMAPEVINGTGYARRADVWSLGCTLHEMAVGRPPFADMAPMAALLHIGIRNGIMPGLPQAFSKEAQ 257
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92]) HSP 1 Score: 133.265 bits (334), Expect = 3.918e-34 Identity = 90/236 (38.14%), Postives = 122/236 (51.69%), Query Frame = 1
Query: 784 CMEKRIFYNIFPDFENV-IKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGD--NVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRI 1482
C R N D E + KQ+ I +GSFG V+K + +++ A+K + + +EI +L S D P + + + K L+I+MEY+ GGS I+ G L E +I +EIL+ + YLH IHRDIKG NVLL + VKL DF ++ L K +FVGT WMAPE+I YD ADIWS G T IE+ G+PP SEL V+F I
Sbjct: 9 CPHPRPPQNSCADPEELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIE-DIQQEITVL-SQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALDLIKP-GPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIK------RNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLI 235
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66]) HSP 1 Score: 132.88 bits (333), Expect = 1.125e-32 Identity = 87/232 (37.50%), Postives = 121/232 (52.16%), Query Frame = 1
Query: 859 GSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGR-LNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEII-----NGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEF 1536
G+FG VYK S A K + +S E++ + EI IL +L DHP IV F EN L+I +E+ PGG++ + + R L E +I +++LEA+ YLH IIHRD+K N+LL +E VKL DF +S A + +L SF+GT WMAPE++ YD ADIWS G T+IE+ +PP EL V+ +I P + EF
Sbjct: 42 GAFGKVYKAQNKESGVLAAAKVIET--KSEEELEDYMVEIEIL-ALCDHPNIVGLLNAFYYENKLWIFIEFCPGGAVDAIMLELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVS-----AKNTRTLQ-RRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPNHELNPMRVMLKIAKNDPPSLSFPSKWSAEF 264
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897]) HSP 1 Score: 122.479 bits (306), Expect = 2.315e-30 Identity = 66/200 (33.00%), Postives = 109/200 (54.50%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCA-ADIWSFGATVIEMFTGKPPY 1446
I +G+F V + +E A+K + + S + ++E+ I+ L +HP IVK + E LY++MEY GG + Y+ +HGR+ EKE ++I+ A+QY H HI+HRD+K +N+LLD + ++K+ DF S +L +F G+ + APE+ GK+YD D+WS G + + +G P+
Sbjct: 74 IGKGNFAKVKLAKHTLTGQEVAVKIIDKTQLNTSSLQKLFREVRIMKVL-NHPNIVKLFEVIEMEKTLYLVMEYSSGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEF-------TLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 265
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631]) HSP 1 Score: 154.451 bits (389), Expect = 5.538e-40 Identity = 85/227 (37.44%), Postives = 130/227 (57.27%), Query Frame = 1
Query: 835 IKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRS------FSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQ-YDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEK 1494
+K ++I +GSFG+VY C+ + + + A+K++ S S ++ E++ L L DH IV++ K N + +EYV GGS+GS IR +GR +E I + ++L+ + YLH I+HRD+K DN+LLD + K+ DF +S+ SK + + + GT WMAPE+++ KQ Y DIWS G V+EMF GK P+S L A +F+IG K
Sbjct: 1176 MKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDL-DHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISR-----KSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSK 1396
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 141.739 bits (356), Expect = 8.112e-36 Identity = 86/215 (40.00%), Postives = 120/215 (55.81%), Query Frame = 1
Query: 841 QDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYI-RSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELG----YYAV 1470
+ +I RGS+G VYK + ++ + A+KE+ + + E++ EI++L +L +H IVK+ K LYIL+EY GSL I RS L+E E + L ++YLH +IHRDIK N+LL + VKL DF +S I+ N +A + GT NWMAPEI+ + +DIWS GATV+EM T PPY L YYAV
Sbjct: 28 KQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDE--ELNDIMAEISLLKNL-NHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIV---------NSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAV 230
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 138.272 bits (347), Expect = 1.002e-34 Identity = 77/204 (37.75%), Postives = 117/204 (57.35%), Query Frame = 1
Query: 838 KQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEII-NGKQYDCAADIWSFGATVIEMFTGKPPY 1446
+ ++I RG FG VYK + + + +A+K L D E++ +EI L SL I ++ + K+ L+I+ME+ GGSL S +R G+++EK I +E+L A++ +H ++IHRDIK NVL+ E +VKLCDF ++ + + + ++ GT WMAPE+I G YD DIWS G T E+ TG PPY
Sbjct: 25 RTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNL-DSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRP-GKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLR------RQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPY 220
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 132.109 bits (331), Expect = 8.496e-33 Identity = 73/208 (35.10%), Postives = 111/208 (53.37%), Query Frame = 1
Query: 823 FENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPY 1446
+ N++K I +G+ G VY ++ + A+K++ + E L EI ++ HP IV F + + L+++MEY+ GGSL + +H L E +I +E L +++LH ++HRDIK DN+LL E +KL DF A LN + VGT WMAPE+++ K+Y DIWS G +IEM G+PPY
Sbjct: 620 YANLVK---IGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKE--LIINEILVMKG-SKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVV-THCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGF------CAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPY 814
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: PKH2 (Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication [Source:SGD;Acc:S000005460]) HSP 1 Score: 131.724 bits (330), Expect = 1.397e-32 Identity = 75/219 (34.25%), Postives = 120/219 (54.79%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKEL--RFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKIL---IHAASKG--SLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRI 1482
+I G++ +V ++++K +A K L + R ++ E L L + P +V+ F E+ LY L+EY P G S ++ +G L+E + +I++AI YLH IIHRDIK +N+LLD E +KL DF +K+L ++ SK L+ +KSFVGTA +++PE++N D DIW+FG + +M GKPP+ Y ++
Sbjct: 184 VIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQ-KKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKV 401
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7]) HSP 1 Score: 164.081 bits (414), Expect = 1.682e-46 Identity = 90/224 (40.18%), Postives = 130/224 (58.04%), Query Frame = 1
Query: 829 NVIKQDLIDRGSFGSVYKCVQLNSRKEFALKEL---RFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
N K L+ G+FG VY C L++ +E A+K++ + + +E+ EI + + + RIV++ + +YI MEY+PGGS+ +I+ HG LNE + S++ILE I YLH I+HRDIKG N+L D +VKL DF SK L SK +S GT WMAPE+ING+ Y AD+WS G TV+EM T KPP+++ A +F+I +
Sbjct: 3 NWRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEIEFMKAFRNE-RIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRSKTGF----RSVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIATQ 221
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9]) HSP 1 Score: 142.895 bits (359), Expect = 3.212e-38 Identity = 81/231 (35.06%), Postives = 126/231 (54.55%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCS-QEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQ 1539
+ GS+GSV+K + S + A+K++ D EI KEI+++ D P +VK+ + K L+I+MEY GS+ ++ + +E I+C + L+ ++YLH IHRDIK N+LL+ E H KL DF ++ L +K + + +GT WMAPE+I YDC ADIWS G T +EM GKPPY+++ IF I + + P + ++F+
Sbjct: 30 LGEGSYGSVFKAMHKESGQVVAIKQVP-VDTDLQEI---IKEISMMQQC-DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDLMKIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRN------TVIGTPFWMAPEVIQEVGYDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPPPTFRDPGQWSEDFK 249
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO47821 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL88]) HSP 1 Score: 130.954 bits (328), Expect = 2.384e-34 Identity = 74/222 (33.33%), Postives = 125/222 (56.31%), Query Frame = 1
Query: 838 KQDLIDRGSFGSVYKCVQLNSRKEFALKELRF----CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKEN--CLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIG 1485
K +++ +G+FG+V+ + +N+ + A+K++ D + + + +E+ +L SL H IV++ ++ + I ME+VPGGS+ ++ G E R +++IL+ + YLH ++IHRDIKG N++L +KL DF +K + + S + +S GT WMAPE+I + +DIWS G TV EM TG+PP+S + + IF IG
Sbjct: 7 KGNVLGKGAFGTVFLGL-VNTGELIAVKQVELHPNNVDAAERQYEKLQEEVGLLKSL-KHKNIVQYIGTCMDDSQCTINIFMEFVPGGSIAQALKRFGAFVEPVFRRYTRQILDGVSYLHNNNVIHRDIKGGNIMLMPNGVIKLIDFGCAKKICMVGAHVSKSNILRSMRGTPYWMAPEVIRETGHGRKSDIWSIGCTVFEMATGQPPWSNVPPLSAIFAIG 226
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO33667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRJ0]) HSP 1 Score: 132.109 bits (331), Expect = 3.864e-33 Identity = 87/257 (33.85%), Postives = 131/257 (50.97%), Query Frame = 1
Query: 850 IDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQXXXXXXXXXXXXXXXXXXXXXEHPFLK 1620
I +G+ G+VY +++ + E A+K++ + E L EI ++ HP IV + + L+++MEY+ GGSL + + ++E +I +E L+A+++LH +IHRDIK DN+LL + VKL DF + +K S + VGT WMAPE++ KQY D+WS G IEM G+PPY ++ I P+ F+ FL L KR SA LL+HPFLK
Sbjct: 232 IGQGASGTVYTAIEVATGHEVAIKQMNLSQQPKKE--LIINEILVMRE-NKHPNIVNYVDSYLVGEELWVVMEYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALEFLHSNGVIHRDIKSDNILLGMDGQVKLTDFGFCATITPEQNKRS------TMVGTPYWMAPEVVTRKQYGPRVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELAHPEKLSPVFKDFLAQSLEMDVEKRSSARELLQHPFLK 478
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO36150 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJF2]) HSP 1 Score: 128.642 bits (322), Expect = 3.205e-31 Identity = 79/245 (32.24%), Postives = 128/245 (52.24%), Query Frame = 1
Query: 823 FENV--IKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEID----LFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYE-RHVKLCDF-SLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSE---LGYYAVIFRIGFEKKIVYEVPKHF 1524
ENV K +L+ G+F S Y + + A+K++ FC S SE D EIAIL L HP ++K I +E++ GGS+ + +G E +IR ++IL+ + YLH ++HRDIKG N+L+D + +++ DF + +++ G G +GT +MAPE++ G+ Y + D+WS G +IEM TGKPP++ + A+IF+I ++P+H
Sbjct: 572 LENVHWKKGELLGTGAFSSCYGARDVMTGSLMAVKQVSFCRNSKSEQDKVCQTIMDEIAILARL-KHPHLIKCLGATRHTGHFNIFLEWMAGGSISMLLSKYGPFEEAILIRYLRQILQGVSYLHENQVVHRDIKGANILVDSTGQDIRIADFGAAARLATQITGAGEFQG---QLLGTIAFMAPEVLRGESYGRSCDVWSVGCVLIEMATGKPPWNAHEHSNHLALIFKIACAIG-PPDIPEHL 811
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127]) HSP 1 Score: 161.77 bits (408), Expect = 1.752e-42 Identity = 95/272 (34.93%), Postives = 148/272 (54.41%), Query Frame = 1
Query: 712 IPVKNIQLFNNETQLELCE------NSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
+P + +N E+ L+ E +++ C P N + L+ RG+FG VY C ++ +E A K++ F C + E++ EI +L +L H RIV++ + + L I +E++PGGS+ ++++G L EK R +++IL+ + YLH I+HRDIKG N+L D +VKL DF SK + ++GT KS GT WM+PE+ING+ Y AD+WS TV+EM T KPP++E A IF+I +
Sbjct: 283 VPSSRTRSYNGESTLQFTELRSLGRSADKSCQRGTAKSPRAP--VNWRQGKLLGRGAFGEVYLCYDADTGRELAAKQVPFDPDCQETSKEVNALECEIQLLKNL-RHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC----MSGTGIKSVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQ 547
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127]) HSP 1 Score: 162.155 bits (409), Expect = 1.976e-42 Identity = 95/272 (34.93%), Postives = 148/272 (54.41%), Query Frame = 1
Query: 712 IPVKNIQLFNNETQLELCE------NSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
+P + +N E+ L+ E +++ C P N + L+ RG+FG VY C ++ +E A K++ F C + E++ EI +L +L H RIV++ + + L I +E++PGGS+ ++++G L EK R +++IL+ + YLH I+HRDIKG N+L D +VKL DF SK + ++GT KS GT WM+PE+ING+ Y AD+WS TV+EM T KPP++E A IF+I +
Sbjct: 313 VPSSRTRSYNGESTLQFTELRSLGRSADKSCQRGTAKSPRAP--VNWRQGKLLGRGAFGEVYLCYDADTGRELAAKQVPFDPDCQETSKEVNALECEIQLLKNL-RHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC----MSGTGIKSVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQ 577
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127]) HSP 1 Score: 162.155 bits (409), Expect = 1.976e-42 Identity = 95/272 (34.93%), Postives = 148/272 (54.41%), Query Frame = 1
Query: 712 IPVKNIQLFNNETQLELCE------NSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
+P + +N E+ L+ E +++ C P N + L+ RG+FG VY C ++ +E A K++ F C + E++ EI +L +L H RIV++ + + L I +E++PGGS+ ++++G L EK R +++IL+ + YLH I+HRDIKG N+L D +VKL DF SK + ++GT KS GT WM+PE+ING+ Y AD+WS TV+EM T KPP++E A IF+I +
Sbjct: 313 VPSSRTRSYNGESTLQFTELRSLGRSADKSCQRGTAKSPRAP--VNWRQGKLLGRGAFGEVYLCYDADTGRELAAKQVPFDPDCQETSKEVNALECEIQLLKNL-RHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC----MSGTGIKSVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQ 577
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297]) HSP 1 Score: 159.458 bits (402), Expect = 2.109e-41 Identity = 92/231 (39.83%), Postives = 135/231 (58.44%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKH 1521
L+ +G+FG VY C ++ +E A+K+++F + E+ EI +L +L H RIV++ + E L I ME++PGGS+ ++S+G L E R +++ILE + YLH I+HRDIKG N+L D +VKL DF S+ L L+GT KS GT WM+PE+I+G+ Y ADIWS G TV+EM T +PP++E A IF+I + E+P H
Sbjct: 394 LLGQGAFGRVYLCYDADTGRELAVKQVQFDPESPETSKEVSALECEIQLLKNLC-HERIVQYYGCLRDTMERTLSIFMEHMPGGSIKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTIC----LSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTQRPPWAEFEAMAAIFKIATQ-PTNPELPVH 618
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290]) HSP 1 Score: 157.147 bits (396), Expect = 8.343e-41 Identity = 87/221 (39.37%), Postives = 131/221 (59.28%), Query Frame = 1
Query: 847 LIDRGSFGSVYKCVQLNSRKEFALKELRF---CDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQ--KFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTA-KSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFE 1491
L+ +G+FG VY C +++ +E A K+++F + E+ EI +L +L H RIV++ + E L I MEY+PGGS+ ++++G L E + +++ILE + YLH I+HRDIKG N+L D +VKL DF SK L ++GT +S GT WM+PE+I+G+ Y AD+WS G TV+EM T KPP++E A IF+I +
Sbjct: 358 LLGQGAFGLVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNL-HHERIVQYYGCLRDHSEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC----MSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ 573
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000003368.1 (SMESG000003368.1) HSP 1 Score: 1010.36 bits (2611), Expect = 0.000e+0 Identity = 519/524 (99.05%), Postives = 521/524 (99.43%), Query Frame = 1
Query: 55 MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDDILIKDYQISPDDFVLVCIIENERKFSDKVSVDLTDSSCANHTNNDNRFHDMFSLITIIVESVTYSDTYIIKTNPNEIVFDALKRHLPSLRYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQXXXXXXXXXXXXXXXXXXXXXEHPFLKCE 1626
MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDDILIKDYQISPDDFVLVCIIENERKFSDKVSVDLTDSSCANHTNNDNRFHDMFSLITIIV+SVTYSDTYIIKT PNEIVFDALKRHLPSLRYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHF EITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKF+KENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILI AASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQSFLDSCLCSSSSKRLSADALLEHPFLKCE
Sbjct: 1 MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDDILIKDYQISPDDFVLVCIIENERKFSDKVSVDLTDSSCANHTNNDNRFHDMFSLITIIVKSVTYSDTYIIKTKPNEIVFDALKRHLPSLRYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFYEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFSKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIQAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQSFLDSCLCSSSSKRLSADALLEHPFLKCE 524
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000003368.1 (SMESG000003368.1) HSP 1 Score: 1006.13 bits (2600), Expect = 0.000e+0 Identity = 517/522 (99.04%), Postives = 519/522 (99.43%), Query Frame = 1
Query: 55 MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDDILIKDYQISPDDFVLVCIIENERKFSDKVSVDLTDSSCANHTNNDNRFHDMFSLITIIVESVTYSDTYIIKTNPNEIVFDALKRHLPSLRYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQXXXXXXXXXXXXXXXXXXXXXEHPFLK 1620
MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDDILIKDYQISPDDFVLVCIIENERKFSDKVSVDLTDSSCANHTNNDNRFHDMFSLITIIV+SVTYSDTYIIKT PNEIVFDALKRHLPSLRYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHF EITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKF+KENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILI AASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQSFLDSCLCSSSSKRLSADALLEHPFLK
Sbjct: 1 MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDDILIKDYQISPDDFVLVCIIENERKFSDKVSVDLTDSSCANHTNNDNRFHDMFSLITIIVKSVTYSDTYIIKTKPNEIVFDALKRHLPSLRYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFYEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFSKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIQAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQSFLDSCLCSSSSKRLSADALLEHPFLK 522
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000003368.1 (SMESG000003368.1) HSP 1 Score: 1005.36 bits (2598), Expect = 0.000e+0 Identity = 517/522 (99.04%), Postives = 519/522 (99.43%), Query Frame = 1
Query: 55 MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDDILIKDYQISPDDFVLVCIIENERKFSDKVSVDLTDSSCANHTNNDNRFHDMFSLITIIVESVTYSDTYIIKTNPNEIVFDALKRHLPSLRYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFCEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQXXXXXXXXXXXXXXXXXXXXXEHPFLK 1620
MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDDILIKDYQISPDDFVLVCIIENERKFSDKVSVDLTDSSCANHTNNDNRFHDMFSLITIIV+SVTYSDTYIIKT PNEIVFDALKRHLPSLRYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHF EITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKF+KENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILI AASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQSFLDSCLCSSSSKRLSADALLEHPFLK
Sbjct: 1 MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDDILIKDYQISPDDFVLVCIIENERKFSDKVSVDLTDSSCANHTNNDNRFHDMFSLITIIVKSVTYSDTYIIKTKPNEIVFDALKRHLPSLRYLCFTHNESYVDTTRTFSDCNLNDGDLILMENLLETKHEHFYEITLESINHNYESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSENLCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFCDRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFSKENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIQAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQSFLDSCLCSSSSKRLSADALLEHPFLK 522
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000009500.1 (SMESG000009500.1) HSP 1 Score: 190.274 bits (482), Expect = 7.422e-53 Identity = 113/305 (37.05%), Postives = 170/305 (55.74%), Query Frame = 1
Query: 637 ESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSEN--LCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFC-DRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAK-ENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQ 1539
E I++ ++ D +K +L +EI I +K+ Q ++ + E S + + I Y EN++ QD + G FG VY+C L + K A+KE++ ++ S++ KEI L H RI+++ F K E I MEY+ GSL SY+ +G L E+EI R S ++LE + YLH I+HRDIKG N+LLD + + KL DF LSK +S G +S VGT NW APE++N + Y ADIWSFGATV+EM G+ PY++ + F++ +KKI + PK ++ +
Sbjct: 257 EKITVSDCKKAVADRVK-RLPEEI-ILIKSNQCLKDDETISNYEYSPDSYFALRSGISYFRLSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEISSWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLE 559
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000009500.1 (SMESG000009500.1) HSP 1 Score: 189.889 bits (481), Expect = 1.397e-52 Identity = 113/305 (37.05%), Postives = 170/305 (55.74%), Query Frame = 1
Query: 637 ESISLFVTRQETIDYIKLKLSKEINIPVKNIQLFNNETQLELCENSEN--LCMEKRIFYNIFPDFENVIKQDLIDRGSFGSVYKCVQLNSRKEFALKELRFC-DRSFSEIDLFYKEIAILCSLGDHPRIVKFEQKFAK-ENCLYILMEYVPGGSLGSYIRSHGRLNEKEIIRCSQEILEAIQYLHYLHIIHRDIKGDNVLLDYERHVKLCDFSLSKILIHAASKGSLNGTAKSFVGTANWMAPEIINGKQYDCAADIWSFGATVIEMFTGKPPYSELGYYAVIFRIGFEKKIVYEVPKHFKKEFQ 1539
E I++ ++ D +K +L +EI I +K+ Q ++ + E S + + I Y EN++ QD + G FG VY+C L + K A+KE++ ++ S++ KEI L H RI+++ F K E I MEY+ GSL SY+ +G L E+EI R S ++LE + YLH I+HRDIKG N+LLD + + KL DF LSK +S G +S VGT NW APE++N + Y ADIWSFGATV+EM G+ PY++ + F++ +KKI + PK ++ +
Sbjct: 285 EKITVSDCKKAVADRVK-RLPEEI-ILIKSNQCLKDDETISNYEYSPDSYFALRSGISYFRLSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEISSWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLE 587 The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30008378 ID=SMED30008378|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1722bpback to top protein sequence of SMED30008378-orf-1 >SMED30008378-orf-1 ID=SMED30008378-orf-1|Name=SMED30008378-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=525bp MKIISFDNIIYKIDVDENDDSYKVKQKLSEKINTRPDNIGLVYKNRILFDback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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