Ferrochelatase

Overview
NameFerrochelatase
Smed IDSMED30008264
Length (bp)1382
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Ferrochelatase (SMED30008264) t-SNE clustered cells

Violin plots show distribution of expression levels for Ferrochelatase (SMED30008264) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Ferrochelatase (SMED30008264) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Ferrochelatase (SMED30008264) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30008264

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30008264h1SMcG0018036 SmedASXL_010390SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30008264h1SMcG0018036 SmedASXL_010390SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Ferrochelatase vs. Ensembl Human
Match: FECH (ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647])

HSP 1 Score: 400.979 bits (1029), Expect = 1.798e-136
Identity = 202/364 (55.49%), Postives = 256/364 (70.33%), Query Frame = 3 
Query:  102 RLYSTTNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            R  S   KPKTGILM+NMGGP+    VHDFLL LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW TH  LIQ FA HI +E+   P E +S+ +ILFSAHS+PMS+VNRGD YPQEV ATVQKVME L++  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA    + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  L CP C N  C  +K  F   Q
Sbjct:   65 RYESNIRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQ 428
[Close]
BLAST of Ferrochelatase vs. Ensembl Human
Match: FECH (ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647])

HSP 1 Score: 398.667 bits (1023), Expect = 1.125e-135
Identity = 200/357 (56.02%), Postives = 254/357 (71.15%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+    VHDFLL LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW TH  LIQ FA HI +E+   P E +S+ +ILFSAHS+PMS+VNRGD YPQEV ATVQKVME L++  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA    + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  L CP C N  C  +K  F   Q
Sbjct:   66 KPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQ 422
[Close]
BLAST of Ferrochelatase vs. Ensembl Human
Match: FECH (ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647])

HSP 1 Score: 385.571 bits (989), Expect = 1.090e-131
Identity = 193/350 (55.14%), Postives = 247/350 (70.57%), Query Frame = 3 
Query:  144 MMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            M+NMGGP+    VHDFLL LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW TH  LIQ FA HI +E+   P E +S+ +ILFSAHS+PMS+VNRGD YPQEV ATVQKVME L++  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA    + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  L CP C N  C  +K  F   Q
Sbjct:    1 MLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQ 350
[Close]
BLAST of Ferrochelatase vs. Ensembl Human
Match: FECH (ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647])

HSP 1 Score: 293.508 bits (750), Expect = 6.872e-96
Identity = 158/293 (53.92%), Postives = 195/293 (66.55%), Query Frame = 3 
Query:  120 NKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLA 992
             KPKTGILM+NMGGP+    VHDFLL LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW TH  LIQ                                 +VNRGD YPQEV ATVQKVME L++  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA
Sbjct:   65 RKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQ---------------------------------VVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLA 324
[Close]
BLAST of Ferrochelatase vs. Ensembl Human
Match: FECH (ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647])

HSP 1 Score: 167.162 bits (422), Expect = 1.478e-49
Identity = 79/129 (61.24%), Postives = 99/129 (76.74%), Query Frame = 3 
Query:  666 PEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLF 1052
            P E +S+ +ILFSAHS+PMS+VNRGD YPQEV ATVQKVME L++  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA    + +  R  ++N NPLF
Sbjct:    5 PLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLF 133
[Close]
BLAST of Ferrochelatase vs. Ensembl Fly
Match: FeCH (gene:FBgn0266268 transcript:FBtr0085849)

HSP 1 Score: 387.882 bits (995), Expect = 2.519e-132
Identity = 178/358 (49.72%), Postives = 243/358 (67.88%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVENR--SSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQS 1190
            KPKT ILM+NMGGP  TD+VHD+LL + +DRD+++LP Q     +IA  R  +++ +Y  IGGGSPI KWTE+QGQ M + LD+I PE+APHK Y+GFRY  P T +++ ++ KD  ER V FSQYPQ+ C+TSGSS N +      N   S I WS+IDRW THP LI+ FAQ I+ E+++  E  ++  +ILF+AHS+P+  VNRGD YP E+GA+V  VM+ L    PY L WQS+VGP  WL P+T D I G  K   K+ +LVPIAF ++H+ETL+E+DIEYC +LA    +    R A  ND+PLFI  L  +V++HL S +  + ++ +RCP C+N +C  SK  +R + S
Sbjct:   26 KPKTAILMLNMGGPTHTDQVHDYLLRIMTDRDMIQLPVQSRLGPWIAQRRTPEVQKKYKEIGGGSPILKWTELQGQLMCEQLDRISPETAPHKHYVGFRYVNPLTENTLAEIEKDKPERVVLFSQYPQYSCATSGSSFNSIFTHYRSNNLPSDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRNDVVILFTAHSLPLKAVNRGDAYPSEIGASVHMVMQELGQTNPYSLAWQSKVGPLPWLAPATDDAIKGYVKQGLKNFILVPIAFVNEHIETLHELDIEYCDELAKEVGVEEIRRAATPNDHPLFIDALTNVVADHLKSQQAVNPKFLMRCPMCSNPKCRESKSWYRQLCS 383
[Close]
BLAST of Ferrochelatase vs. Ensembl Fly
Match: FeCH (gene:FBgn0266268 transcript:FBtr0085850)

HSP 1 Score: 293.893 bits (751), Expect = 4.415e-97
Identity = 134/254 (52.76%), Postives = 177/254 (69.69%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVENR--SSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDII 878
            KPKT ILM+NMGGP  TD+VHD+LL + +DRD+++LP Q     +IA  R  +++ +Y  IGGGSPI KWTE+QGQ M + LD+I PE+APHK Y+GFRY  P T +++ ++ KD  ER V FSQYPQ+ C+TSGSS N +      N   S I WS+IDRW THP LI+ FAQ I+ E+++  E  ++  +ILF+AHS+P+  VNRGD YP E+GA+V  VM+ L    PY L WQS+VGP  WL P+T D I
Sbjct:   26 KPKTAILMLNMGGPTHTDQVHDYLLRIMTDRDMIQLPVQSRLGPWIAQRRTPEVQKKYKEIGGGSPILKWTELQGQLMCEQLDRISPETAPHKHYVGFRYVNPLTENTLAEIEKDKPERVVLFSQYPQYSCATSGSSFNSIFTHYRSNNLPSDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRNDVVILFTAHSLPLKAVNRGDAYPSEIGASVHMVMQELGQTNPYSLAWQSKVGPLPWLAPATDDAI 279
[Close]
BLAST of Ferrochelatase vs. Ensembl Fly
Match: FeCH (gene:FBgn0266268 transcript:FBtr0085851)

HSP 1 Score: 218.779 bits (556), Expect = 1.145e-68
Identity = 99/207 (47.83%), Postives = 138/207 (66.67%), Query Frame = 3 
Query:  570 SSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQS 1190
            S I WS+IDRW THP LI+ FAQ I+ E+++  E  ++  +ILF+AHS+P+  VNRGD YP E+GA+V  VM+ L    PY L WQS+VGP  WL P+T D I G  K   K+ +LVPIAF ++H+ETL+E+DIEYC +LA    +    R A  ND+PLFI  L  +V++HL S +  + ++ +RCP C+N +C  SK  +R + S
Sbjct:   19 SDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRNDVVILFTAHSLPLKAVNRGDAYPSEIGASVHMVMQELGQTNPYSLAWQSKVGPLPWLAPATDDAIKGYVKQGLKNFILVPIAFVNEHIETLHELDIEYCDELAKEVGVEEIRRAATPNDHPLFIDALTNVVADHLKSQQAVNPKFLMRCPMCSNPKCRESKSWYRQLCS 225
[Close]
BLAST of Ferrochelatase vs. Ensembl Zebrafish
Match: fech (ferrochelatase [Source:ZFIN;Acc:ZDB-GENE-000928-1])

HSP 1 Score: 437.958 bits (1125), Expect = 1.397e-151
Identity = 198/355 (55.77%), Postives = 259/355 (72.96%), Query Frame = 3 
Query:  117 TNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVE--NRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            + KPKTGILM+NMGGP+K + VHDFLL LF D DLM+LP Q     FIA  R   I+ QY+ IGGGSPI+ WT +QG+ MV++LD++CP++APHKFYIGFRY  P T ++IE M KDG+ERAVAF+QYPQ+ CST+GSS+N +        +R  + WS+IDRW THP LI+ FA+H++ E+ + P E +   +ILFSAHS+P+S+VNRGD YPQEVGATVQ+VM+ L    PY+LVWQS+VGP  WLGP T ++I GL +  K++++LVPIAFTSDH+ETL+E+DIEY   L     + +  R  ++N NPLF R LA+LV +HL S + CS Q  LRCP C N  C+ +K  F
Sbjct:   50 SRKPKTGILMLNMGGPEKLEDVHDFLLRLFMDTDLMQLPVQNKLGPFIAKRRTPKIQEQYSKIGGGSPIKAWTTMQGEGMVKLLDEMCPDTAPHKFYIGFRYVHPLTEEAIELMEKDGVERAVAFTQYPQYSCSTTGSSLNAIYRYYSNRADRPKMRWSVIDRWPTHPLLIECFAEHVRNELDKFPVEKRDDVVILFSAHSLPLSVVNRGDPYPQEVGATVQRVMDRLGHCNPYRLVWQSKVGPMAWLGPQTDEVIKGLCQRGKRNLLLVPIAFTSDHIETLHELDIEYSQVLGEEVGVENIRRAESLNGNPLFFRALADLVQSHLQSNESCSRQLTLRCPLCVNPTCAQTKAFF 404
[Close]
BLAST of Ferrochelatase vs. Ensembl Xenopus
Match: FECH (ferrochelatase [Source:NCBI gene;Acc:100496154])

HSP 1 Score: 436.417 bits (1121), Expect = 1.755e-151
Identity = 203/357 (56.86%), Postives = 258/357 (72.27%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVEN--RSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+  D VHDFLL LF D+DLM LP Q   A FIA  R   I+ QY+ IGGGSPIRKWTE QG  MV++LD++ P +APHK+Y+GFRY  P T  +IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +         +  + WS+IDRW THP LIQ FA HI++E++  P + +   +ILFSAHS+PMS+VNRGD YPQEVGATVQKVME L +  PY+LVWQS+VGP  WLGP T + I GL +  KK+I+LVPIAFTSDH+ETLYE+DIEY   LA+   + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  LRCP C N  C  +K  F   Q
Sbjct:    9 KPKTGILMLNMGGPETVDDVHDFLLRLFLDKDLMTLPAQSKLAPFIAKRRTPKIQKQYSKIGGGSPIRKWTEQQGDGMVKLLDELSPATAPHKYYVGFRYVNPLTEAAIEEMERDGVERAIAFTQYPQYSCSTTGSSLNAIYRYYNTKGAQPKMKWSVIDRWPTHPLLIQCFADHIQKELNMFPADKRGDVVILFSAHSLPMSVVNRGDPYPQEVGATVQKVMERLGYSNPYRLVWQSKVGPMPWLGPHTDESIKGLCQRGKKNILLVPIAFTSDHIETLYELDIEYAQVLANECGVENIRRSESLNGNPLFSKALADLVLSHMKSNEICSKQLTLRCPMCVNPVCGEAKSFFTKQQ 365
[Close]
BLAST of Ferrochelatase vs. Ensembl Xenopus
Match: FECH (ferrochelatase [Source:NCBI gene;Acc:100496154])

HSP 1 Score: 437.187 bits (1123), Expect = 3.071e-151
Identity = 203/357 (56.86%), Postives = 258/357 (72.27%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVEN--RSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+  D VHDFLL LF D+DLM LP Q   A FIA  R   I+ QY+ IGGGSPIRKWTE QG  MV++LD++ P +APHK+Y+GFRY  P T  +IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +         +  + WS+IDRW THP LIQ FA HI++E++  P + +   +ILFSAHS+PMS+VNRGD YPQEVGATVQKVME L +  PY+LVWQS+VGP  WLGP T + I GL +  KK+I+LVPIAFTSDH+ETLYE+DIEY   LA+   + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  LRCP C N  C  +K  F   Q
Sbjct:   44 KPKTGILMLNMGGPETVDDVHDFLLRLFLDKDLMTLPAQSKLAPFIAKRRTPKIQKQYSKIGGGSPIRKWTEQQGDGMVKLLDELSPATAPHKYYVGFRYVNPLTEAAIEEMERDGVERAIAFTQYPQYSCSTTGSSLNAIYRYYNTKGAQPKMKWSVIDRWPTHPLLIQCFADHIQKELNMFPADKRGDVVILFSAHSLPMSVVNRGDPYPQEVGATVQKVMERLGYSNPYRLVWQSKVGPMPWLGPHTDESIKGLCQRGKKNILLVPIAFTSDHIETLYELDIEYAQVLANECGVENIRRSESLNGNPLFSKALADLVLSHMKSNEICSKQLTLRCPMCVNPVCGEAKSFFTKQQ 400
[Close]
BLAST of Ferrochelatase vs. Ensembl Xenopus
Match: FECH (ferrochelatase [Source:NCBI gene;Acc:100496154])

HSP 1 Score: 437.187 bits (1123), Expect = 4.821e-151
Identity = 203/357 (56.86%), Postives = 258/357 (72.27%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVEN--RSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+  D VHDFLL LF D+DLM LP Q   A FIA  R   I+ QY+ IGGGSPIRKWTE QG  MV++LD++ P +APHK+Y+GFRY  P T  +IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +         +  + WS+IDRW THP LIQ FA HI++E++  P + +   +ILFSAHS+PMS+VNRGD YPQEVGATVQKVME L +  PY+LVWQS+VGP  WLGP T + I GL +  KK+I+LVPIAFTSDH+ETLYE+DIEY   LA+   + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  LRCP C N  C  +K  F   Q
Sbjct:   60 KPKTGILMLNMGGPETVDDVHDFLLRLFLDKDLMTLPAQSKLAPFIAKRRTPKIQKQYSKIGGGSPIRKWTEQQGDGMVKLLDELSPATAPHKYYVGFRYVNPLTEAAIEEMERDGVERAIAFTQYPQYSCSTTGSSLNAIYRYYNTKGAQPKMKWSVIDRWPTHPLLIQCFADHIQKELNMFPADKRGDVVILFSAHSLPMSVVNRGDPYPQEVGATVQKVMERLGYSNPYRLVWQSKVGPMPWLGPHTDESIKGLCQRGKKNILLVPIAFTSDHIETLYELDIEYAQVLANECGVENIRRSESLNGNPLFSKALADLVLSHMKSNEICSKQLTLRCPMCVNPVCGEAKSFFTKQQ 416
[Close]
BLAST of Ferrochelatase vs. Ensembl Xenopus
Match: FECH (ferrochelatase [Source:NCBI gene;Acc:100496154])

HSP 1 Score: 434.491 bits (1116), Expect = 3.119e-150
Identity = 203/357 (56.86%), Postives = 258/357 (72.27%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVEN--RSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+  D VHDFLL LF D+DLM LP Q   A FIA  R   I+ QY+ IGGGSPIRKWTE QG  MV++LD++ P +APHK+Y+GFRY  P T  +IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +         +  + WS+IDRW THP LIQ FA HI++E++  P + +   +ILFSAHS+PMS+VNRGD YPQEVGATVQKVME L +  PY+LVWQS+VGP  WLGP T + I GL +  KK+I+LVPIAFTSDH+ETLYE+DIEY   LA+   + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  LRCP C N  C  +K  F   Q
Sbjct:   42 KPKTGILMLNMGGPETVDDVHDFLLRLFLDKDLMTLPAQSKLAPFIAKRRTPKIQKQYSKIGGGSPIRKWTEQQGDGMVKLLDELSPATAPHKYYVGFRYVNPLTEAAIEEMERDGVERAIAFTQYPQYSCSTTGSSLNAIYRYYNTKGAQPKMKWSVIDRWPTHPLLIQCFADHIQKELNMFPADKRGDVVILFSAHSLPMSVVNRGDPYPQEVGATVQKVMERLGYSNPYRLVWQSKVGPMPWLGPHTDESIKGLCQRGKKNILLVPIAFTSDHIETLYELDIEYAQVLANECGVENIRRSESLNGNPLFSKALADLVLSHMKSNEICSKQLTLRCPMCVNPVCGEAKSFFTKQQ 398
[Close]
BLAST of Ferrochelatase vs. Ensembl Xenopus
Match: FECH (ferrochelatase [Source:NCBI gene;Acc:100496154])

HSP 1 Score: 383.645 bits (984), Expect = 1.764e-130
Identity = 187/357 (52.38%), Postives = 234/357 (65.55%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVEN--RSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+  D VHDFLL LF D+DLM LP Q   A FIA  R   I+ QY+ IGGGSPIRKWTE QG  MV++LD++ P +APHK+Y+GFRY  P T  +IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +         +  + WS+IDRW THP LIQ                                 +VNRGD YPQEVGATVQKVME L +  PY+LVWQS+VGP  WLGP T + I GL +  KK+I+LVPIAFTSDH+ETLYE+DIEY   LA+   + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  LRCP C N  C  +K  F   Q
Sbjct:   60 KPKTGILMLNMGGPETVDDVHDFLLRLFLDKDLMTLPAQSKLAPFIAKRRTPKIQKQYSKIGGGSPIRKWTEQQGDGMVKLLDELSPATAPHKYYVGFRYVNPLTEAAIEEMERDGVERAIAFTQYPQYSCSTTGSSLNAIYRYYNTKGAQPKMKWSVIDRWPTHPLLIQ---------------------------------VVNRGDPYPQEVGATVQKVMERLGYSNPYRLVWQSKVGPMPWLGPHTDESIKGLCQRGKKNILLVPIAFTSDHIETLYELDIEYAQVLANECGVENIRRSESLNGNPLFSKALADLVLSHMKSNEICSKQLTLRCPMCVNPVCGEAKSFFTKQQ 383
[Close]
BLAST of Ferrochelatase vs. Ensembl Mouse
Match: Fech (ferrochelatase [Source:MGI Symbol;Acc:MGI:95513])

HSP 1 Score: 431.409 bits (1108), Expect = 1.050e-148
Identity = 202/357 (56.58%), Postives = 255/357 (71.43%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+   +V DFL  LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW THP LIQ FA HI +E++  PEE +S+ +ILFSAHS+PMS+VNRGD YPQEVGATV KVME L +  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA      +  R  ++N NPLF + LA+LV +H+ S K+CSTQ  L CP C N  C  +K  F   Q
Sbjct:   65 KPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVILFSAHSLPMSVVNRGDPYPQEVGATVHKVMEKLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHIQSNKLCSTQLSLNCPLCVNPVCRKTKSFFTSQQ 421
[Close]
BLAST of Ferrochelatase vs. Ensembl Mouse
Match: Fech (ferrochelatase [Source:MGI Symbol;Acc:MGI:95513])

HSP 1 Score: 431.024 bits (1107), Expect = 1.077e-148
Identity = 202/357 (56.58%), Postives = 255/357 (71.43%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+   +V DFL  LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW THP LIQ FA HI +E++  PEE +S+ +ILFSAHS+PMS+VNRGD YPQEVGATV KVME L +  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA      +  R  ++N NPLF + LA+LV +H+ S K+CSTQ  L CP C N  C  +K  F   Q
Sbjct:   60 KPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVILFSAHSLPMSVVNRGDPYPQEVGATVHKVMEKLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHIQSNKLCSTQLSLNCPLCVNPVCRKTKSFFTSQQ 416
[Close]
BLAST of Ferrochelatase vs. Ensembl Mouse
Match: Fech (ferrochelatase [Source:MGI Symbol;Acc:MGI:95513])

HSP 1 Score: 411.379 bits (1056), Expect = 5.185e-142
Identity = 193/347 (55.62%), Postives = 245/347 (70.61%), Query Frame = 3 
Query:  153 MGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            MGGP+   +V DFL  LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW THP LIQ FA HI +E++  PEE +S+ +ILFSAHS+PMS+VNRGD YPQEVGATV KVME L +  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA      +  R  ++N NPLF + LA+LV +H+ S K+CSTQ  L CP C N  C  +K  F   Q
Sbjct:    1 MGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVILFSAHSLPMSVVNRGDPYPQEVGATVHKVMEKLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHIQSNKLCSTQLSLNCPLCVNPVCRKTKSFFTSQQ 347
[Close]
BLAST of Ferrochelatase vs. Ensembl Mouse
Match: Fech (ferrochelatase [Source:MGI Symbol;Acc:MGI:95513])

HSP 1 Score: 389.808 bits (1000), Expect = 7.458e-133
Identity = 182/312 (58.33%), Postives = 229/312 (73.40%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVE--NRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLF 1052
            KPKTGILM+NMGGP+   +V DFL  LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +     E   + ++ WS IDRW THP LIQ FA HI +E++  PEE +S+ +ILFSAHS+PMS+VNRGD YPQEVGATV KVME L +  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA      +  R  ++N NPLF
Sbjct:   65 KPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVILFSAHSLPMSVVNRGDPYPQEVGATVHKVMEKLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLF 376
[Close]
BLAST of Ferrochelatase vs. Ensembl Mouse
Match: Fech (ferrochelatase [Source:MGI Symbol;Acc:MGI:95513])

HSP 1 Score: 311.612 bits (797), Expect = 1.130e-102
Identity = 148/258 (57.36%), Postives = 187/258 (72.48%), Query Frame = 3 
Query:  120 NKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGL 887
             KPKTGILM+NMGGP+   +V DFL  LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW THP LIQ FA HI +E++  PEE +S+ +ILFSAHS+PMS+VNRGD YPQEVGATV KVME L +  PY+LVWQS+  P   L  ST+ I+  L
Sbjct:   64 RKPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVILFSAHSLPMSVVNRGDPYPQEVGATVHKVMEKLGYPNPYRLVWQSKHLPVTTLRRSTNWILNTL 321
[Close]
BLAST of Ferrochelatase vs. UniProt/SwissProt
Match: sp|O57478|HEMH_XENLA (Ferrochelatase, mitochondrial OS=Xenopus laevis OX=8355 GN=fech PE=1 SV=1)

HSP 1 Score: 438.343 bits (1126), Expect = 7.386e-151
Identity = 203/359 (56.55%), Postives = 259/359 (72.14%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVE--NRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQSE 1193
            KPKTGILM+NMGGP+  D VH FLL LF D+DLM LP Q   A FIA  R   I+ QY+ IGGGSPI+KWTE QG+ MV++LD++ P +APHK+YIGFRY  P T  +IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +         +  + WS+IDRW THP LIQ FA HI++E++  P + + + +ILFSAHS+PMS+VNRGD YPQEVGATVQKVME L F  PY+LVWQS+VGP  WLGP T + I GL +  KK+I+LVPIAFTSDH+ETLYE+DIEY   LA    + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  LRCP C N  C  +K  F   Q +
Sbjct:   53 KPKTGILMLNMGGPETLDDVHGFLLRLFLDKDLMTLPAQSKLAPFIAKRRTPKIQEQYSKIGGGSPIKKWTEQQGEGMVKLLDELSPATAPHKYYIGFRYVRPLTEAAIEEMERDGVERAIAFTQYPQYSCSTTGSSLNAIYRYYNAKGTQPKMKWSVIDRWPTHPLLIQCFADHIQKELNMFPADKRGEVVILFSAHSLPMSVVNRGDPYPQEVGATVQKVMERLGFSNPYRLVWQSKVGPMAWLGPQTDESIKGLCQRGKKNILLVPIAFTSDHIETLYELDIEYAQVLAKECGVENIRRSESLNGNPLFSKALADLVLSHMKSSEICSKQLSLRCPMCVNPVCGEAKSFFTKQQQQ 411
[Close]
BLAST of Ferrochelatase vs. UniProt/SwissProt
Match: sp|P22600|HEMH_BOVIN (Ferrochelatase, mitochondrial OS=Bos taurus OX=9913 GN=FECH PE=1 SV=3)

HSP 1 Score: 426.787 bits (1096), Expect = 3.332e-146
Identity = 199/358 (55.59%), Postives = 254/358 (70.95%), Query Frame = 3 
Query:  120 NKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
             KP+TGILM+NMGGP+  ++V DFL  LF D+DLM LP Q     FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERAVAF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW THP LIQ FA HI +E+   P E + + +ILFSAHS+PMS+VNRGD YPQEVGATVQ+VM+ L +  PY+LVWQS+VGP  WLGP T + I GL K  +K+I+LVPIAFTSDH+ETLYE+DIEY   LAS   + +  R  ++N NPLF + LA+LV +HL S + CSTQ  L CP C N  C  +K  F   Q
Sbjct:   58 RKPRTGILMLNMGGPETVEEVQDFLQRLFLDQDLMTLPVQDKLGPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPHTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAVAFTQYPQYSCSTTGSSLNAIYRYYNEVGRKPTMKWSTIDRWPTHPLLIQCFADHILKELDHFPPEKRREVVILFSAHSLPMSVVNRGDPYPQEVGATVQRVMDKLGYSNPYRLVWQSKVGPMPWLGPQTDEAIKGLCKRGRKNILLVPIAFTSDHIETLYELDIEYSQVLASECGLENIRRAESLNGNPLFSKALADLVHSHLQSKERCSTQLTLSCPLCVNPTCRETKSFFTSQQ 415
[Close]
BLAST of Ferrochelatase vs. UniProt/SwissProt
Match: sp|P22315|HEMH_MOUSE (Ferrochelatase, mitochondrial OS=Mus musculus OX=10090 GN=Fech PE=1 SV=2)

HSP 1 Score: 422.55 bits (1085), Expect = 1.652e-144
Identity = 201/357 (56.30%), Postives = 253/357 (70.87%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+   +V DFL  LF DRDLM LP Q   A FIA  R   I  Q   IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW THP LIQ FA HI +E++  PEE +S+ +ILFSAHS+PMS+VNRGD YPQEVGATV KVME L +  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA      +  R  ++N NPLF + LA+LV +H+ S K+CSTQ  L CP C N  C  +K  F   Q
Sbjct:   65 KPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKI--QERRIGGGSPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVILFSAHSLPMSVVNRGDPYPQEVGATVHKVMEKLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHIQSNKLCSTQLSLNCPLCVNPVCRKTKSFFTSQQ 419
[Close]
BLAST of Ferrochelatase vs. UniProt/SwissProt
Match: sp|O42479|HEMH_CHICK (Ferrochelatase, mitochondrial OS=Gallus gallus OX=9031 GN=FECH PE=1 SV=1)

HSP 1 Score: 406.371 bits (1043), Expect = 2.218e-138
Identity = 201/359 (55.99%), Postives = 258/359 (71.87%), Query Frame = 3 
Query:  117 TNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAEL--IVENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            T KPKTGILM+NMGGP++ D VHDFLL LF DRDLM LP Q   A FIA  R   I+ QY+ IGGGSPI+KWT +QG+ MV++LD + P++APHK+YIGFRY  P T ++IE+M  DGIERA+AF+QYPQ+ CST+GSS+N +         +  + WS+IDRW THP LIQ FA HI++E+   P + +   +ILFSAHS+PMS+VNRGD YPQEVGATVQ+VME L+   PY+LVWQS+VGP  WL P T + I GL +  KK+++LVPIAFTSDH+ETLYE+DIEY   LA+   + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  L CP C N  C  +K  F   Q
Sbjct:   43 TRKPKTGILMLNMGGPERLDDVHDFLLRLFLDRDLMTLPAQNKLAPFIAKRRTPRIQEQYSRIGGGSPIKKWTAVQGEGMVKLLDSMSPQTAPHKYYIGFRYVHPLTEEAIEEMEDDGIERAIAFTQYPQYSCSTTGSSLNAIYRYYNKKGKKPKMKWSIIDRWPTHPLLIQCFADHIQKELDLFPPDKRKDVVILFSAHSLPMSVVNRGDPYPQEVGATVQRVMEKLNHSNPYRLVWQSKVGPMPWLVPQTDETIKGLCQRGKKNMLLVPIAFTSDHIETLYELDIEYAQVLANECGVENIRRAESLNGNPLFSKALADLVCSHIQSNEICSKQLTLCCPLCVNPVCRETKAFFTNQQ 401
[Close]
BLAST of Ferrochelatase vs. UniProt/SwissProt
Match: sp|Q3YA36|HEMH_PANTR (Ferrochelatase, mitochondrial OS=Pan troglodytes OX=9598 GN=FECH PE=2 SV=1)

HSP 1 Score: 399.053 bits (1024), Expect = 2.971e-135
Identity = 200/357 (56.02%), Postives = 254/357 (71.15%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQ 1187
            KPKTGILM+NMGGP+    VHDFLL LF DRDLM LP Q   A FIA  R   I+ QY  IGGGSPI+ WT  QG+ MV++LD++ P +APHK+YIGFRY  P T ++IE+M +DG+ERA+AF+QYPQ+ CST+GSS+N +      V  + ++ WS IDRW TH  LIQ FA HI +E+   P E +S+ +ILFSAHS+PMS+VNRGD YPQEV ATVQKVME L++  PY+LVWQS+VGP  WLGP T + I GL +  +K+I+LVPIAFTSDH+ETLYE+DIEY   LA    + +  R  ++N NPLF + LA+LV +H+ S ++CS Q  L CP C N  C  +K  F   Q
Sbjct:   66 KPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQ 422
[Close]
BLAST of Ferrochelatase vs. TrEMBL
Match: A7S629 (Ferrochelatase OS=Nematostella vectensis OX=45351 GN=v1g186132 PE=3 SV=1)

HSP 1 Score: 454.907 bits (1169), Expect = 5.579e-155
Identity = 207/352 (58.81%), Postives = 264/352 (75.00%), Query Frame = 3 
Query:  126 PKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVENR--SSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            PKTGIL++N+GGP+K + VH FLL LFSD+DL+ LP QK  A +IA  R   I+ QY  IGGGSPI+ WTE QGQ MV++LD++ PE+APHKFY+GFRYA P T D+IEQM +DGIERA+AF+QYPQ+ CST+GSSIN + +   + +  SS+ WS IDRW THP LI+AFA ++K E+S+ PEE Q   +ILFSAHS+PM +V+RGD YPQEV ATVQ+VME LDF   Y+LVWQS+VGP  WLGP T D I GL K  KK+++LVPIAFTSDH+ETL+E+DIEY  +LA    + +  R  ++NDNP+FI+ +A++V  HL SG+ CS Q  LRCP C N  C  +K  F
Sbjct:   51 PKTGILLLNLGGPEKQEDVHGFLLRLFSDKDLIPLPAQKQLAAWIAKRRTPKIKEQYQKIGGGSPIKMWTEKQGQGMVELLDQLSPETAPHKFYVGFRYATPLTEDAIEQMERDGIERAIAFTQYPQYSCSTTGSSINAIYKYYKQRQGNSSLKWSAIDRWPTHPGLIKAFADNVKVELSKFPEEVQKDVVILFSAHSLPMKVVDRGDPYPQEVAATVQRVMEALDFSHSYRLVWQSKVGPLPWLGPQTEDAIKGLAKNNKKNLLLVPIAFTSDHIETLHELDIEYAQELAHEVGVENIRRAESLNDNPIFIQAMADIVHKHLQSGETCSRQLPLRCPMCVNATCGPAKEFF 402
[Close]
BLAST of Ferrochelatase vs. TrEMBL
Match: A0A1S3MFP0 (Ferrochelatase OS=Salmo salar OX=8030 GN=fech PE=3 SV=1)

HSP 1 Score: 448.358 bits (1152), Expect = 3.013e-152
Identity = 204/353 (57.79%), Postives = 258/353 (73.09%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVE--NRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            KPKTGILMMNMGGP+K D VHDFLL LFSD DLMKLP Q     FIA  R   I+ QY+ IGGGSPI+ WT +QG+ MV++LD++CPE+APHKFYIGFRY  P T ++IE+M KDG+ERAVAF+QYPQ+ CST+GSS+N +        +R  + WS+IDRW THP L++ F+QH+  E+ + P E +   +ILFSAHS+P+S+VNRGD YPQEVGATVQ+VME L    PY+LVWQS+VGP  WLGP T D+I GL +  KK+++LVPIAFTSDH+ETL+E+DIEY   L     + +  R  ++N NP+F + LA+LV  HL S + CS Q  LRCP CTN  C  +K  F
Sbjct:   57 KPKTGILMMNMGGPEKLDDVHDFLLRLFSDTDLMKLPVQNRLGPFIAKRRTPKIQEQYSRIGGGSPIKAWTTMQGEGMVKLLDEMCPETAPHKFYIGFRYVHPLTEEAIEEMEKDGVERAVAFTQYPQYSCSTTGSSLNAIYRYYSSRADRPKMRWSVIDRWPTHPLLVECFSQHVLNELQKFPPEKRDDVVILFSAHSLPLSVVNRGDPYPQEVGATVQRVMERLQHCNPYRLVWQSRVGPMPWLGPQTDDVIKGLCERGKKNLLLVPIAFTSDHIETLHELDIEYSQVLGEECGVENIRRAESLNGNPIFFQALADLVQTHLKSNESCSRQLTLRCPLCTNPTCGETKAFF 409
[Close]
BLAST of Ferrochelatase vs. TrEMBL
Match: A0A5A9PD10 (Ferrochelatase OS=Triplophysa tibetana OX=1572043 GN=E1301_Tti022930 PE=3 SV=1)

HSP 1 Score: 447.588 bits (1150), Expect = 4.886e-152
Identity = 205/355 (57.75%), Postives = 258/355 (72.68%), Query Frame = 3 
Query:  117 TNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVE--NRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            + KPKTGILM+NMGGP+K   VHDFLL LF D DLMKLP Q     FIA  R   I+ QY+ IGGGSPI+ WT +QG+ MV++LD++CPESAPHKFYIGFRY +P T D+IEQM KDG+ERAVAF+QYPQ+ CST+GSS+N +        +R  + WS+IDRW THP LI+ FA H++ E+ + P E +   +ILFSAHS+PM++VNRGD YPQEVGATVQ+VM+ L    PY+LVWQS+VGP  WLGP T D+I GL +  KK+++LVPIAFTSDH+ETL+E+DIEY   L     + +  R  ++N NPLF R LA+LV +HL S + CS Q  LRCP C N  C  +K  F
Sbjct:   50 SRKPKTGILMLNMGGPEKLQDVHDFLLRLFMDTDLMKLPVQNTLGPFIAKRRTPKIQEQYSKIGGGSPIKAWTTMQGEGMVKLLDEMCPESAPHKFYIGFRYVQPLTEDAIEQMEKDGVERAVAFTQYPQYSCSTTGSSLNAIYRYYTNRGDRPKMRWSVIDRWPTHPLLIECFADHVRNELEKFPPEKRDDVVILFSAHSLPMAVVNRGDPYPQEVGATVQRVMDRLGHCNPYRLVWQSRVGPMAWLGPQTDDVIKGLCQRGKKNLLLVPIAFTSDHIETLHELDIEYSQILGEECGVENIRRAESLNGNPLFFRALADLVQSHLKSNEPCSRQLTLRCPLCVNPTCGQTKAFF 404
[Close]
BLAST of Ferrochelatase vs. TrEMBL
Match: A0A3P8YFL1 (Ferrochelatase OS=Esox lucius OX=8010 PE=3 SV=1)

HSP 1 Score: 446.817 bits (1148), Expect = 9.851e-152
Identity = 204/353 (57.79%), Postives = 259/353 (73.37%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVE--NRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            KPKTGILMMNMGGP+K D VHDFLL LFSD DLMKLP Q     FIA  R   I+ QY+ IGGGSPI+ WT +QG+ MV++LD++CPE+APHKFYIGFRY  P T ++IE+M KDG+ERAVAF+QYPQ+ CST+GSS+N +        +R  + WS+IDRW THP L++ FAQH+ +E+ + P E +   +ILFSAHS+P+S+VNRGD YPQEVGATVQ+VME L    PY+LVWQS+VGP  WLGP T D+I GL +  K++++LVPIAFTSDH+ETL+E+DIEY   L     + +  R  ++N NP+F + LA+LV  HL S + CS Q  LRCP CTN  C  +K  F
Sbjct:   55 KPKTGILMMNMGGPEKLDDVHDFLLRLFSDTDLMKLPVQNRLGPFIAKRRTPKIQEQYSRIGGGSPIKAWTTMQGEGMVKLLDEMCPETAPHKFYIGFRYVHPLTEEAIEEMEKDGVERAVAFTQYPQYSCSTTGSSLNAIYRYYKGRGDRPKMRWSVIDRWPTHPLLVECFAQHVLKELQKFPPEKRDDVVILFSAHSLPLSVVNRGDPYPQEVGATVQRVMEKLQHCNPYRLVWQSRVGPMPWLGPQTDDVIKGLCERGKRNLLLVPIAFTSDHIETLHELDIEYSQVLGEECGVENIRRAESLNGNPMFFQALADLVHTHLKSDEPCSRQLTLRCPLCTNPTCGATKAFF 407
[Close]
BLAST of Ferrochelatase vs. TrEMBL
Match: A0A3Q3AEN3 (Ferrochelatase OS=Kryptolebias marmoratus OX=37003 PE=3 SV=1)

HSP 1 Score: 446.047 bits (1146), Expect = 1.448e-151
Identity = 204/353 (57.79%), Postives = 260/353 (73.65%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIV--ENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            KPKTGILM+NMGGP+K   VHDFLL LF D DLMKLP Q     FIA  R   I+ QY+ IGGGSPIR+WT +QG+ MV++LD++ PE+APHKFYIGFRY  P T D+IE+M KDG+ERAVAF+QYPQ+ CST+GSS+N +       E R  + WS+IDRW THP L++ FA+H+++E+   PEE +   +ILFSAHS+PM++VNRGD YPQEVGATVQ+VME L    P++LVWQS+VGP  WLGP T ++I GL +  KK+I+LVPIAFTSDH+ETL+E+DIEY   L     + +  R  ++N NPLF++ LA+LV +HL S + CS Q  LRCP CTN  C  +K  F
Sbjct:   44 KPKTGILMLNMGGPEKLQDVHDFLLRLFMDTDLMKLPVQNKLGPFIAKRRTPKIQEQYSKIGGGSPIRRWTSMQGEGMVKLLDEMNPETAPHKFYIGFRYVNPLTEDAIEEMEKDGVERAVAFTQYPQYSCSTTGSSLNAIYRYYSSREARPKMRWSVIDRWPTHPLLVECFAEHVRKELREFPEEKRDDVVILFSAHSLPMAVVNRGDPYPQEVGATVQRVMERLGHCNPFRLVWQSRVGPMPWLGPQTDEVIKGLCERGKKNILLVPIAFTSDHIETLHELDIEYAQVLGEECGVENIRRAESLNGNPLFMKALADLVQSHLKSNEPCSRQLTLRCPLCTNPTCGETKAFF 396
[Close]
BLAST of Ferrochelatase vs. Ensembl Cavefish
Match: fech (ferrochelatase [Source:NCBI gene;Acc:103045973])

HSP 1 Score: 435.647 bits (1119), Expect = 1.002e-150
Identity = 200/355 (56.34%), Postives = 257/355 (72.39%), Query Frame = 3 
Query:  117 TNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIV--ENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            + KPKTGILM+NMGGP+K + VHDFLL LF D DLM++P Q     FIA  R   I+ QY+ IGGGSPI+ WT +QG+ MV++LD++ PE+APHKFYIGFRY  P T ++IE M KDG+ERAVAF+QYPQ+ CST+GSS+N +       + R  + WS+IDRW THP LI+ FA+H++ E+ + P E +   +ILFSAHS+PMS+VNRGD YPQEVGATVQ+VME L    PY+LVWQS+VGP  WLGP T ++I GL +  KK+++LVPIAFTSDH+ETL+E+DIEY   L     + +  R  ++N NPLF + LA+LV  HLSS + CS Q  LRCP C N  C  +K  F
Sbjct:   50 SRKPKTGILMLNMGGPEKLEDVHDFLLRLFMDTDLMQIPVQNKLGPFIAKRRTPKIQEQYSKIGGGSPIKAWTTMQGEGMVKLLDEMSPETAPHKFYIGFRYVHPLTEEAIEVMEKDGVERAVAFTQYPQYSCSTTGSSLNAIYRYYSSRDTRPKMRWSVIDRWPTHPLLIECFAEHVRIELEKFPPEKRDDVVILFSAHSLPMSVVNRGDPYPQEVGATVQRVMERLGHCNPYRLVWQSKVGPMAWLGPQTDEVIKGLCQRGKKNLLLVPIAFTSDHIETLHELDIEYSQILGEECGVENIRRAESLNGNPLFFKALADLVKTHLSSNEPCSRQLTLRCPLCVNPTCGQAKAFF 404
[Close]
BLAST of Ferrochelatase vs. Ensembl Cavefish
Match: fech (ferrochelatase [Source:NCBI gene;Acc:103045973])

HSP 1 Score: 395.586 bits (1015), Expect = 1.931e-135
Identity = 181/317 (57.10%), Postives = 235/317 (74.13%), Query Frame = 3 
Query:  117 TNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIV--ENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRG 1061
            + KPKTGILM+NMGGP+K + VHDFLL LF D DLM++P Q     FIA  R   I+ QY+ IGGGSPI+ WT +QG+ MV++LD++ PE+APHKFYIGFRY  P T ++IE M KDG+ERAVAF+QYPQ+ CST+GSS+N +       + R  + WS+IDRW THP LI+ FA+H++ E+ + P E +   +ILFSAHS+PMS+VNRGD YPQEVGATVQ+VME L    PY+LVWQS+VGP  WLGP T ++I GL +  KK+++LVPIAFTSDH+ETL+E+DIEY   L     + +  R  ++N NPLF +G
Sbjct:   50 SRKPKTGILMLNMGGPEKLEDVHDFLLRLFMDTDLMQIPVQNKLGPFIAKRRTPKIQEQYSKIGGGSPIKAWTTMQGEGMVKLLDEMSPETAPHKFYIGFRYVHPLTEEAIEVMEKDGVERAVAFTQYPQYSCSTTGSSLNAIYRYYSSRDTRPKMRWSVIDRWPTHPLLIECFAEHVRIELEKFPPEKRDDVVILFSAHSLPMSVVNRGDPYPQEVGATVQRVMERLGHCNPYRLVWQSKVGPMAWLGPQTDEVIKGLCQRGKKNLLLVPIAFTSDHIETLHELDIEYSQILGEECGVENIRRAESLNGNPLFFKG 366
[Close]
BLAST of Ferrochelatase vs. Ensembl Sea Lamprey
Match: fech (ferrochelatase [Source:ZFIN;Acc:ZDB-GENE-000928-1])

HSP 1 Score: 186.808 bits (473), Expect = 2.277e-57
Identity = 85/141 (60.28%), Postives = 106/141 (75.18%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPES------APHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSG 527
            KP+TGIL++NMGGP+ TD VHDFL  LF D+DL+ LP Q   A +IA  R   I+ QY+ IGGGSPI+ WT  QG+ MV++LD +CP S      APHKFYIGFRY +P T D+IE+M +DGI+RAVAF+QYPQF CST+G
Sbjct:   47 KPRTGILLLNMGGPETTDDVHDFLKRLFLDKDLIPLPAQSKLAPWIAKRRTPKIQEQYSRIGGGSPIKLWTSRQGEGMVRLLDHMCPGSACLTSAAPHKFYIGFRYVQPLTEDTIEEMERDGIQRAVAFTQYPQFSCSTTG 187
[Close]
BLAST of Ferrochelatase vs. Ensembl Yeast
Match: HEM15 (Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid [Source:SGD;Acc:S000005702])

HSP 1 Score: 355.14 bits (910), Expect = 3.192e-120
Identity = 169/346 (48.84%), Postives = 240/346 (69.36%), Query Frame = 3 
Query:   99 YRLYSTTNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLP--FQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELI--VENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKL 1124
            + + +   +  TGI++MNMGGP K ++ +DFL  LF+D DL+ +   +QK  A++IA +R   IE QY  IGGGSPIRKW+E Q   + +ILDK CPE+APHK Y+ FRYA+P T ++ +QM KDG+++AVAFSQYP F  ST+GSSIN+L   I  +++  SI+WS+IDRW T+  LI+AF+++I +++   P+  + + ++LFSAHS+PM +VN GD YP EV ATV  +M+ L FK PY+LVWQSQVGPK WLG  T++I   LG  +   ++ +PIAFTSDH+ETL+E+D+   G+     K     RC ++N N  FI G+A+LV +HL S ++ S Q  L
Sbjct:   28 FNMQNAQKRSPTGIVLMNMGGPSKVEETYDFLYQLFADNDLIPISAKYQKTIAKYIAKFRTPKIEKQYREIGGGSPIRKWSEYQATEVCKILDKTCPETAPHKPYVAFRYAKPLTAETYKQMLKDGVKKAVAFSQYPHFSYSTTGSSINELWRQIKALDSERSISWSVIDRWPTNEGLIKAFSENITKKLQEFPQPVRDKVVLLFSAHSLPMDVVNTGDAYPAEVAATVYNIMQKLKFKNPYRLVWQSQVGPKPWLGAQTAEIAEFLGP-KVDGLMFIPIAFTSDHIETLHEIDLGVIGESEYKDKFK---RCESLNGNQTFIEGMADLVKSHLQSNQLYSNQLPL 369
[Close]
BLAST of Ferrochelatase vs. Ensembl Nematostella
Match: EDO40867 (Ferrochelatase [Source:UniProtKB/TrEMBL;Acc:A7S629])

HSP 1 Score: 454.907 bits (1169), Expect = 7.715e-159
Identity = 207/352 (58.81%), Postives = 264/352 (75.00%), Query Frame = 3 
Query:  126 PKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVENR--SSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            PKTGIL++N+GGP+K + VH FLL LFSD+DL+ LP QK  A +IA  R   I+ QY  IGGGSPI+ WTE QGQ MV++LD++ PE+APHKFY+GFRYA P T D+IEQM +DGIERA+AF+QYPQ+ CST+GSSIN + +   + +  SS+ WS IDRW THP LI+AFA ++K E+S+ PEE Q   +ILFSAHS+PM +V+RGD YPQEV ATVQ+VME LDF   Y+LVWQS+VGP  WLGP T D I GL K  KK+++LVPIAFTSDH+ETL+E+DIEY  +LA    + +  R  ++NDNP+FI+ +A++V  HL SG+ CS Q  LRCP C N  C  +K  F
Sbjct:   51 PKTGILLLNLGGPEKQEDVHGFLLRLFSDKDLIPLPAQKQLAAWIAKRRTPKIKEQYQKIGGGSPIKMWTEKQGQGMVELLDQLSPETAPHKFYVGFRYATPLTEDAIEQMERDGIERAIAFTQYPQYSCSTTGSSINAIYKYYKQRQGNSSLKWSAIDRWPTHPGLIKAFADNVKVELSKFPEEVQKDVVILFSAHSLPMKVVDRGDPYPQEVAATVQRVMEALDFSHSYRLVWQSKVGPLPWLGPQTEDAIKGLAKNNKKNLLLVPIAFTSDHIETLHELDIEYAQELAHEVGVENIRRAESLNDNPIFIQAMADIVHKHLQSGETCSRQLPLRCPMCVNATCGPAKEFF 402
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BLAST of Ferrochelatase vs. Ensembl Nematostella
Match: EDO27506 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T926])

HSP 1 Score: 257.299 bits (656), Expect = 1.458e-83
Identity = 138/291 (47.42%), Postives = 178/291 (61.17%), Query Frame = 3 
Query:  129 KTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAV-AFSQYPQFCCSTSGSSINQLAELIVENRSSIAWSLIDRWATHPPLIQAFAQHIKQE--ISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLA 992
            KTGIL++N+GGP+K + VH FLL LFSD+DL+ LP QK  A +IA  R   I+ QY  IGGGSPI+ WTE QGQ MV++LD++ PE+APHKFY+GFRYA P T D+IEQM +  +   V   +Q+PQ+                       +WS+             +  H+K+   +SR+                      +RGD YPQEV ATVQ+VME LDF   Y+LVWQS+VGP  WLGP T D I GL K  KK+++LVPIAFTSDH+ETL+E+DIEY  +LA
Sbjct:    2 KTGILLLNLGGPEKQEDVHGFLLRLFSDKDLIPLPAQKQLAAWIAKRRTPKIKEQYQKIGGGSPIKMWTEKQGQGMVELLDQLSPETAPHKFYVGFRYATPLTEDAIEQMERYTLVLEVWRNAQFPQW-----------------------SWSM------------DYLLHLKKAGFLSRL----------------------DRGDPYPQEVAATVQRVMEALDFSHSYRLVWQSKVGPLPWLGPQTEDAIKGLAKNNKKNLLLVPIAFTSDHIETLHELDIEYAQELA 235
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BLAST of Ferrochelatase vs. Ensembl Medaka
Match: fech (ferrochelatase [Source:NCBI gene;Acc:101161911])

HSP 1 Score: 441.039 bits (1133), Expect = 6.507e-153
Identity = 199/353 (56.37%), Postives = 260/353 (73.65%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVE--NRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            KPKTGILM+NMGGP+K + VHDFLL LF D DLMKLP Q     FIA  R   I+ QY+ IGGGSPI++WT +QG+ MV++LD++ P++APHKFYIGFRY  P T ++IE+M KDG+ERAVAF+QYPQ+ CST+GSS+N +         R ++ WS+IDRW THP L++ FA+H+  E+ + PE+ +   +ILFSAHS+PM++VNRGD YPQEVGATVQ+VME L    PY+LVWQS+VGP  WLGP T ++I GL +  KK+++LVPIAFTSDH+ETL+E+DIEY   L     + +  R  ++N NPLF++ LA+LV +HL S + CS Q  LRCP CTN  C  +K  F
Sbjct:   47 KPKTGILMLNMGGPEKLEDVHDFLLRLFLDTDLMKLPVQSKLGPFIAKRRTPKIQEQYSKIGGGSPIKRWTSMQGEGMVKLLDEMSPDTAPHKFYIGFRYVNPLTEEAIEEMEKDGVERAVAFTQYPQYSCSTTGSSLNAIYRYYSNKGGRPNMRWSVIDRWPTHPLLVECFAEHVLNELQKFPEDKRDDVVILFSAHSLPMAVVNRGDPYPQEVGATVQRVMERLGHCNPYRLVWQSRVGPMAWLGPQTDEVIKGLCERGKKNLLLVPIAFTSDHIETLHELDIEYAQVLGEECGVENIRRAESLNGNPLFMKALADLVQSHLKSNEPCSRQLTLRCPLCTNPTCGETKAFF 399
[Close]
BLAST of Ferrochelatase vs. Ensembl Medaka
Match: fech (ferrochelatase [Source:NCBI gene;Acc:101161911])

HSP 1 Score: 437.187 bits (1123), Expect = 1.725e-151
Identity = 199/353 (56.37%), Postives = 260/353 (73.65%), Query Frame = 3 
Query:  123 KPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVE--NRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVF 1175
            KPKTGILM+NMGGP+K + VHDFLL LF D DLMKLP Q     FIA  R   I+ QY+ IGGGSPI++WT +QG+ MV++LD++ P++APHKFYIGFRY  P T ++IE+M KDG+ERAVAF+QYPQ+ CST+GSS+N +         R ++ WS+IDRW THP L++ FA+H+  E+ + PE+ +   +ILFSAHS+PM++VNRGD YPQEVGATVQ+VME L    PY+LVWQS+VGP  WLGP T ++I GL +  KK+++LVPIAFTSDH+ETL+E+DIEY   L     + +  R  ++N NPLF++ LA+LV +HL S + CS Q  LRCP CTN  C  +K  F
Sbjct:   45 KPKTGILMLNMGGPEKLEDVHDFLLRLFLDTDLMKLPVQSKLGPFIAKRRTPKIQEQYSKIGGGSPIKRWTSMQGEGMVKLLDEMSPDTAPHKFYIGFRYVNPLTEEAIEEMEKDGVERAVAFTQYPQYSCSTTGSSLNAIYRYYSNKGGRPNMRWSVIDRWPTHPLLVECFAEHVLNELQKFPEDKRDDVVILFSAHSLPMAVVNRGDPYPQEVGATVQRVMERLGHCNPYRLVWQSRVGPMAWLGPQTDEVIKGLCERGKKNLLLVPIAFTSDHIETLHELDIEYAQVLGEECGVENIRRAESLNGNPLFMKALADLVQSHLKSNEPCSRQLTLRCPLCTNPTCGETKAFF 397
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BLAST of Ferrochelatase vs. Planmine SMEST
Match: SMESG000039135.1 (SMESG000039135.1)

HSP 1 Score: 830.091 bits (2143), Expect = 0.000e+0
Identity = 394/394 (100.00%), Postives = 394/394 (100.00%), Query Frame = 3 
Query:   69 MKSIFNTLCRYRLYSTTNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQSEVTKWTSETFPKQIKEAATA 1250
            MKSIFNTLCRYRLYSTTNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQSEVTKWTSETFPKQIKEAATA
Sbjct:    1 MKSIFNTLCRYRLYSTTNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRDLMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQILDKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCSTSGSSINQLAELIVENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIPEEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQLVWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMDIEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQYKLRCPKCTNERCSNSKGVFRMMQSEVTKWTSETFPKQIKEAATA 394
The following BLAST results are available for this feature:
BLAST of Ferrochelatase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FECH1.798e-13655.49ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647][more]
FECH1.125e-13556.02ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647][more]
FECH1.090e-13155.14ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647][more]
FECH6.872e-9653.92ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647][more]
FECH1.478e-4961.24ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647][more]
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BLAST of Ferrochelatase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ferrochelatase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
FeCH2.519e-13249.72gene:FBgn0266268 transcript:FBtr0085849[more]
FeCH4.415e-9752.76gene:FBgn0266268 transcript:FBtr0085850[more]
FeCH1.145e-6847.83gene:FBgn0266268 transcript:FBtr0085851[more]
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BLAST of Ferrochelatase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
fech1.397e-15155.77ferrochelatase [Source:ZFIN;Acc:ZDB-GENE-000928-1][more]
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BLAST of Ferrochelatase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FECH1.755e-15156.86ferrochelatase [Source:NCBI gene;Acc:100496154][more]
FECH3.071e-15156.86ferrochelatase [Source:NCBI gene;Acc:100496154][more]
FECH4.821e-15156.86ferrochelatase [Source:NCBI gene;Acc:100496154][more]
FECH3.119e-15056.86ferrochelatase [Source:NCBI gene;Acc:100496154][more]
FECH1.764e-13052.38ferrochelatase [Source:NCBI gene;Acc:100496154][more]
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BLAST of Ferrochelatase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Fech1.050e-14856.58ferrochelatase [Source:MGI Symbol;Acc:MGI:95513][more]
Fech1.077e-14856.58ferrochelatase [Source:MGI Symbol;Acc:MGI:95513][more]
Fech5.185e-14255.62ferrochelatase [Source:MGI Symbol;Acc:MGI:95513][more]
Fech7.458e-13358.33ferrochelatase [Source:MGI Symbol;Acc:MGI:95513][more]
Fech1.130e-10257.36ferrochelatase [Source:MGI Symbol;Acc:MGI:95513][more]
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BLAST of Ferrochelatase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O57478|HEMH_XENLA7.386e-15156.55Ferrochelatase, mitochondrial OS=Xenopus laevis OX... [more]
sp|P22600|HEMH_BOVIN3.332e-14655.59Ferrochelatase, mitochondrial OS=Bos taurus OX=991... [more]
sp|P22315|HEMH_MOUSE1.652e-14456.30Ferrochelatase, mitochondrial OS=Mus musculus OX=1... [more]
sp|O42479|HEMH_CHICK2.218e-13855.99Ferrochelatase, mitochondrial OS=Gallus gallus OX=... [more]
sp|Q3YA36|HEMH_PANTR2.971e-13556.02Ferrochelatase, mitochondrial OS=Pan troglodytes O... [more]
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BLAST of Ferrochelatase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A7S6295.579e-15558.81Ferrochelatase OS=Nematostella vectensis OX=45351 ... [more]
A0A1S3MFP03.013e-15257.79Ferrochelatase OS=Salmo salar OX=8030 GN=fech PE=3... [more]
A0A5A9PD104.886e-15257.75Ferrochelatase OS=Triplophysa tibetana OX=1572043 ... [more]
A0A3P8YFL19.851e-15257.79Ferrochelatase OS=Esox lucius OX=8010 PE=3 SV=1[more]
A0A3Q3AEN31.448e-15157.79Ferrochelatase OS=Kryptolebias marmoratus OX=37003... [more]
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BLAST of Ferrochelatase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
fech1.002e-15056.34ferrochelatase [Source:NCBI gene;Acc:103045973][more]
fech1.931e-13557.10ferrochelatase [Source:NCBI gene;Acc:103045973][more]
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BLAST of Ferrochelatase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
fech2.277e-5760.28ferrochelatase [Source:ZFIN;Acc:ZDB-GENE-000928-1][more]
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BLAST of Ferrochelatase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
HEM153.192e-12048.84Ferrochelatase; a mitochondrial inner membrane pro... [more]
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BLAST of Ferrochelatase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO408677.715e-15958.81Ferrochelatase [Source:UniProtKB/TrEMBL;Acc:A7S62... [more]
EDO275061.458e-8347.42Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Ferrochelatase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
fech6.507e-15356.37ferrochelatase [Source:NCBI gene;Acc:101161911][more]
fech1.725e-15156.37ferrochelatase [Source:NCBI gene;Acc:101161911][more]
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BLAST of Ferrochelatase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000039135.10.000e+0100.00SMESG000039135.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008264 ID=SMED30008264|Name=Ferrochelatase|organism=Schmidtea mediterranea sexual|type=transcript|length=1382bp
AGATCATAAGTTTCATAAATTCGATTTAAAAAAATTTAACATTGAAATTT
ATTAAATTTGTTTTGGAGATGAAAAGTATTTTTAATACATTATGTAGGTA
TAGGTTATATTCAACAACAAATAAACCGAAAACTGGTATTTTAATGATGA
ATATGGGAGGACCTGACAAAACAGACAAAGTTCATGACTTTCTTCTAAAT
CTATTTTCAGATAGAGATCTAATGAAATTACCATTTCAAAAACATTCTGC
ACAATTTATTGCCAATTATAGGAAAAAAGATATCGAACATCAATATAACA
CAATCGGAGGGGGTTCTCCAATTAGAAAGTGGACGGAAATACAGGGTCAA
TCAATGGTTCAGATATTAGACAAAATTTGCCCAGAATCTGCTCCTCATAA
ATTTTATATTGGATTTCGATATGCTGAACCGTTTACTGGTGATTCTATTG
AACAAATGCACAAAGATGGAATAGAGCGAGCTGTGGCTTTTAGTCAATAT
CCACAGTTTTGTTGCTCAACCAGTGGAAGCAGCATCAATCAATTAGCTGA
ACTGATTGTGGAAAATAGATCATCAATCGCATGGTCACTGATCGATCGAT
GGGCCACTCATCCTCCGCTTATCCAGGCGTTTGCACAGCATATTAAGCAG
GAAATCAGCAGAATTCCAGAAGAATACCAGTCGCAAACGATTATTTTATT
CAGTGCTCACTCCATTCCAATGTCTATTGTTAACCGAGGAGATACTTATC
CACAGGAGGTTGGTGCAACAGTGCAAAAAGTTATGGAAATATTGGATTTT
AAATGGCCCTATCAACTAGTTTGGCAATCTCAAGTTGGTCCCAAGAAATG
GTTAGGTCCTTCAACCAGTGATATAATAATGGGATTAGGTAAATTGGAAA
AGAAAAGCATTGTGCTTGTTCCGATTGCATTTACTTCTGATCATGTTGAA
ACTCTTTATGAAATGGATATTGAATACTGTGGTCAATTGGCATCAAATTC
TAAAATTCCACACGCGTACCGATGTGCAGCAATGAATGATAATCCATTGT
TTATTCGGGGATTGGCTGAATTAGTGAGTAATCATTTGAGTTCTGGGAAA
GTTTGTAGTACGCAATATAAATTGCGATGCCCCAAATGTACTAATGAAAG
ATGTAGCAATAGTAAAGGTGTTTTCAGAATGATGCAATCTGAGGTCACTA
AATGGACATCGGAAACATTTCCCAAACAAATCAAAGAAGCTGCAACCGCT
TAATTGAGCTCAGAATTCATTTTTGAAATTTTAGTTGTTTTAAATTTCTC
TATATTTTTATTGGTCAAAAAATATTAAAGCTCATTTTGATTTATTTTGA
ATATATATATTTAATTCTTATTTCCAAAAAAA
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protein sequence of SMED30008264-orf-1

>SMED30008264-orf-1 ID=SMED30008264-orf-1|Name=SMED30008264-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=395bp
MKSIFNTLCRYRLYSTTNKPKTGILMMNMGGPDKTDKVHDFLLNLFSDRD
LMKLPFQKHSAQFIANYRKKDIEHQYNTIGGGSPIRKWTEIQGQSMVQIL
DKICPESAPHKFYIGFRYAEPFTGDSIEQMHKDGIERAVAFSQYPQFCCS
TSGSSINQLAELIVENRSSIAWSLIDRWATHPPLIQAFAQHIKQEISRIP
EEYQSQTIILFSAHSIPMSIVNRGDTYPQEVGATVQKVMEILDFKWPYQL
VWQSQVGPKKWLGPSTSDIIMGLGKLEKKSIVLVPIAFTSDHVETLYEMD
IEYCGQLASNSKIPHAYRCAAMNDNPLFIRGLAELVSNHLSSGKVCSTQY
KLRCPKCTNERCSNSKGVFRMMQSEVTKWTSETFPKQIKEAATA*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR033644Ferrochelatase_C
IPR033659Ferrochelatase_N
IPR001015Ferrochelatase
IPR019772Ferrochelatase_AS
Vocabulary: molecular function
TermDefinition
GO:0004325ferrochelatase activity
GO:0016829lyase activity
Vocabulary: biological process
TermDefinition
GO:0006783heme biosynthetic process
GO:0006779porphyrin-containing compound biosynthetic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001015FerrochelatasePFAMPF00762Ferrochelatasecoord: 21..340
e-value: 8.5E-103
score: 343.7
IPR001015FerrochelataseTIGRFAMTIGR00109TIGR00109coord: 18..340
e-value: 1.4E-103
score: 344.7
IPR001015FerrochelatasePANTHERPTHR11108FERROCHELATASEcoord: 15..373
NoneNo IPR availableGENE3DG3DSA:3.40.50.1400coord: 179..321
e-value: 4.4E-133
score: 445.5
NoneNo IPR availableGENE3DG3DSA:3.40.50.1400coord: 21..341
e-value: 4.4E-133
score: 445.5
NoneNo IPR availablePANTHERPTHR11108:SF1FERROCHELATASE, MITOCHONDRIALcoord: 15..373
NoneNo IPR availableSUPERFAMILYSSF53800Chelatasecoord: 19..370
IPR019772Ferrochelatase, active sitePROSITEPS00534FERROCHELATASEcoord: 209..227
IPR033644Ferrochelatase, C-terminalCDDcd00419Ferrochelatase_Ccoord: 186..323
e-value: 7.17862E-49
score: 160.003
IPR033659Ferrochelatase, N-terminalCDDcd03411Ferrochelatase_Ncoord: 22..181
e-value: 4.0604E-59
score: 187.392