Phosphodiesterase

Overview


Name	Phosphodiesterase
Smed ID	SMED30008218
Length (bp)	1727

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Phosphodiesterase (SMED30008218) t-SNE clustered cells

Violin plots show distribution of expression levels for Phosphodiesterase (SMED30008218) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Phosphodiesterase (SMED30008218) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Phosphodiesterase (SMED30008218) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30008218

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30008218	SMESG000009966.1	dd_Smed_v4_14191_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30008218	SMESG000009966.1	dd_Smed_v4_14191_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30008218	SMESG000009966.1	dd_Smed_v4_14191_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30008218	SMESG000009966.1	dd_Smed_v4_14191_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30008218	SMESG000009966.1	dd_Smed_v6_14191_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
reproductive organ	SMED30008218	SMESG000009966.1	Contig35462	newmark_ests	PMID:28434803 Rouhana et al., 2017
reproductive organ	SMED30008218	SMESG000009966.1	Contig35462	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 414.461 bits (1064), Expect = 2.407e-137
Identity = 208/439 (47.38%), Postives = 307/439 (69.93%), Query Frame = 2

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  + + L+ D+++WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q    MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIEALK-DVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

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Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  + + L+ D+++WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q    MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIEALK-DVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

[Close]

BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 415.231 bits (1066), Expect = 1.164e-136
Identity = 208/439 (47.38%), Postives = 307/439 (69.93%), Query Frame = 2

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  + + L+ D+++WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q    MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIEALK-DVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

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Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  + + L+ D+++WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q    MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIEALK-DVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

[Close]

BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 412.535 bits (1059), Expect = 6.493e-135
Identity = 206/432 (47.69%), Postives = 303/432 (70.14%), Query Frame = 2

Query:  191 FIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
             ++   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  + + L+ D+++WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q    MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   97 LVKTSFRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIEALK-DVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 513

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BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-1 (Probable 3',5'-cyclic phosphodiesterase pde-1 [Source:UniProtKB/Swiss-Prot;Acc:O18696])

HSP 1 Score: 380.178 bits (975), Expect = 1.080e-125
Identity = 191/416 (45.91%), Postives = 285/416 (68.51%), Query Frame = 2

Query:  209 RVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXXXXXXXXXXXXX--XXXVNTDAVPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNML 1450
            R+R ++  ++S  +  EDL +++ Y   +++    +E   I ++D     V  + VP E+REWL +TF+   +   R +KPKF++VANAIR GI  EK              +F+K  ++    IP +I++ ++ ++  WSF  F+L+++S GHAL+++G +LF RY F+ ++K+ L   +N+  ALE GYSK+ NPYHN+VH ADV Q+ HFM+    L N L D+++ A +F ALIHD+EHTG TNNFH+ + S   +LYND+ VLENHHVS+CFRLM++   N++ ++ +++Y+E R++VIE+VL TDMSTHF Q+K+MKSML+L E IDK  AL  I+H  DISHPAK W+LH RWT  +LEEFFRQGD E+ + +P+SPLCDR ++ + +SQ+GF +FIVEP+  + G +L
Sbjct:   21 RLRYILHQLNSGQLPLEDLKRNIEYAALVLETAYMDETRRICDEDDDLAEVTPETVPDEVREWLAATFTRQNAGKKR-DKPKFKSVANAIRTGIFFEK--------------LFRK-QQVVQCPIPPEIAELMK-EVCTWSFSPFQLNEVSEGHALKYVGFELFNRYGFMDRFKVPLTALENYLSALEVGYSKHNNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMSTHFMQIKTMKSMLSLPEGIDKNKALCLIVHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTVHVADSQIGFIDFIVEPTMVVCGELL 419

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BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-1 (Probable 3',5'-cyclic phosphodiesterase pde-1 [Source:UniProtKB/Swiss-Prot;Acc:O18696])

HSP 1 Score: 384.03 bits (985), Expect = 1.338e-125
Identity = 196/449 (43.65%), Postives = 298/449 (66.37%), Query Frame = 2

Query:  158 TSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXXXXXXXX--XXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGN----MLEFIIGMMKKDGI 1486
            +SRK+    +  +E   ++R ++  ++S  +  EDL +++ Y   +++    +E       +DD   V  + VP E+REWL +TF+   +   R +KPKF++VANAIR GI  EK              +F+K  ++    IP +I++ ++ ++  WSF  F+L+++S GHAL+++G +LF RY F+ ++K+ L   +N+  ALE GYSK+ NPYHN+VH ADV Q+ HFM+    L N L D+++ A +F ALIHD+EHTG TNNFH+ + S   +LYND+ VLENHHVS+CFRLM++   N++ ++ +++Y+E R++VIE+VL TDMSTHF Q+K+MKSML+L E IDK  AL  I+H  DISHPAK W+LH RWT  +LEEFFRQGD E+ + +P+SPLCDR ++ + +SQ+GF +FIVEP+  + G     M+E ++ +   D +
Sbjct:  135 SSRKKSYDNAPALESLEKLRYILHQLNSGQLPLEDLKRNIEYAALVLETAYMDETRRICDEDDDLAEVTPETVPDEVREWLAATFTRQNAGKKR-DKPKFKSVANAIRTGIFFEK--------------LFRK-QQVVQCPIPPEIAELMK-EVCTWSFSPFQLNEVSEGHALKYVGFELFNRYGFMDRFKVPLTALENYLSALEVGYSKHNNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMSTHFMQIKTMKSMLSLPEGIDKNKALCLIVHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTVHVADSQIGFIDFIVEPTMVVCGELLVKMVEPLVSLPPTDSL 566

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BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-4 (Probable 3',5'-cyclic phosphodiesterase pde-4 [Source:UniProtKB/Swiss-Prot;Acc:Q22000])

HSP 1 Score: 209.149 bits (531), Expect = 4.654e-60
Identity = 104/291 (35.74%), Postives = 180/291 (61.86%), Query Frame = 2

Query:  611 INEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSM-----------LALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNML 1450
            +++W  D+FK+D++S  H+L  +   L  + N    ++I+      +   LE  Y    N YHN +H ADVAQ++H ++ +  L    TD+++ AAIFA  +HD +H G TN + +N+N++L I+YND+ VLE HH++  F+L+Q  + + + N+ ++   +FR IVI+MVL TDMS H   +  +K+M           + L++  DK   L +++H AD+S+P K  +L+ +W  +++EE++RQGD+E +L +  SP+CDR ++ I +SQVGF ++IV P +    +++
Sbjct:  222 LDDWGPDVFKIDELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHYR--NNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYNDKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVTIEKSQVGFIDYIVHPLYETWADLV 510

[Close]

BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-4 (Probable 3',5'-cyclic phosphodiesterase pde-4 [Source:UniProtKB/Swiss-Prot;Acc:Q22000])

HSP 1 Score: 209.149 bits (531), Expect = 9.233e-60
Identity = 104/291 (35.74%), Postives = 180/291 (61.86%), Query Frame = 2

Query:  611 INEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSM-----------LALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNML 1450
            +++W  D+FK+D++S  H+L  +   L  + N    ++I+      +   LE  Y    N YHN +H ADVAQ++H ++ +  L    TD+++ AAIFA  +HD +H G TN + +N+N++L I+YND+ VLE HH++  F+L+Q  + + + N+ ++   +FR IVI+MVL TDMS H   +  +K+M           + L++  DK   L +++H AD+S+P K  +L+ +W  +++EE++RQGD+E +L +  SP+CDR ++ I +SQVGF ++IV P +    +++
Sbjct:  272 LDDWGPDVFKIDELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHYR--NNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYNDKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVTIEKSQVGFIDYIVHPLYETWADLV 560

[Close]

BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-4 (Probable 3',5'-cyclic phosphodiesterase pde-4 [Source:UniProtKB/Swiss-Prot;Acc:Q22000])

HSP 1 Score: 209.149 bits (531), Expect = 1.431e-59
Identity = 104/291 (35.74%), Postives = 180/291 (61.86%), Query Frame = 2

Query:  611 INEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSM-----------LALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNML 1450
            +++W  D+FK+D++S  H+L  +   L  + N    ++I+      +   LE  Y    N YHN +H ADVAQ++H ++ +  L    TD+++ AAIFA  +HD +H G TN + +N+N++L I+YND+ VLE HH++  F+L+Q  + + + N+ ++   +FR IVI+MVL TDMS H   +  +K+M           + L++  DK   L +++H AD+S+P K  +L+ +W  +++EE++RQGD+E +L +  SP+CDR ++ I +SQVGF ++IV P +    +++
Sbjct:  285 LDDWGPDVFKIDELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHYR--NNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYNDKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVTIEKSQVGFIDYIVHPLYETWADLV 573

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BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0334137)

HSP 1 Score: 388.267 bits (996), Expect = 7.070e-128
Identity = 183/374 (48.93%), Postives = 261/374 (69.79%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFS--TSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEE-NIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIG 1465
            V  DAVP E+REWL STF+   + SR    EKPKFR+VA+AIRAGI V++              ++++ +  A    P D+ + L+ ++++W+FD+F L + + G  ++++  +LF RY  IHK+KI     + F   +E+GY +Y NPYHN +H  DV QT+H+ +    L NWLTD++IFA++ AAL+HD+EHTGTTNNFHV + S+  +LYND+ VLENHH SA FRL+++   N++ ++ +E++RE R +VIEMVL TDM+ HF+QMK+M+ +L L+E  IDK   LS +LHC DISHPAK W +H+RWT  LLEEFFRQGD E +L +PFSPLCDR + ++ ESQ+ F +FIVEPS  ++ +MLE I+ 
Sbjct:  105 VQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDR--------------MYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILA 463

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BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0334135)

HSP 1 Score: 391.349 bits (1004), Expect = 3.607e-125
Identity = 191/424 (45.05%), Postives = 287/424 (67.69%), Query Frame = 2

Query:  209 RVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFS--TSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEE-NIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIG 1465
            R+R +++ +  + +  ED+ ++L Y   +++A+      ++   +D+   V  DAVP E+REWL STF+   + SR    EKPKFR+VA+AIRAGI V++              ++++ +  A    P D+ + L+ ++++W+FD+F L + + G  ++++  +LF RY  IHK+KI     + F   +E+GY +Y NPYHN +H  DV QT+H+ +    L NWLTD++IFA++ AAL+HD+EHTGTTNNFHV + S+  +LYND+ VLENHH SA FRL+++   N++ ++ +E++RE R +VIEMVL TDM+ HF+QMK+M+ +L L+E  IDK   LS +LHC DISHPAK W +H+RWT  LLEEFFRQGD E +L +PFSPLCDR + ++ ESQ+ F +FIVEPS  ++ +MLE I+ 
Sbjct:  402 RIRSLLRRMDHETVAYEDMQRNLHYAARVLEAVFIDESRRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDR--------------MYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILA 810

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BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0334136)

HSP 1 Score: 386.341 bits (991), Expect = 2.094e-124
Identity = 183/374 (48.93%), Postives = 261/374 (69.79%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFS--TSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEE-NIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIG 1465
            V  DAVP E+REWL STF+   + SR    EKPKFR+VA+AIRAGI V++              ++++ +  A    P D+ + L+ ++++W+FD+F L + + G  ++++  +LF RY  IHK+KI     + F   +E+GY +Y NPYHN +H  DV QT+H+ +    L NWLTD++IFA++ AAL+HD+EHTGTTNNFHV + S+  +LYND+ VLENHH SA FRL+++   N++ ++ +E++RE R +VIEMVL TDM+ HF+QMK+M+ +L L+E  IDK   LS +LHC DISHPAK W +H+RWT  LLEEFFRQGD E +L +PFSPLCDR + ++ ESQ+ F +FIVEPS  ++ +MLE I+ 
Sbjct:  334 VQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDR--------------MYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILA 692

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BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0334140)

HSP 1 Score: 386.341 bits (991), Expect = 2.094e-124
Identity = 183/374 (48.93%), Postives = 261/374 (69.79%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFS--TSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEE-NIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIG 1465
            V  DAVP E+REWL STF+   + SR    EKPKFR+VA+AIRAGI V++              ++++ +  A    P D+ + L+ ++++W+FD+F L + + G  ++++  +LF RY  IHK+KI     + F   +E+GY +Y NPYHN +H  DV QT+H+ +    L NWLTD++IFA++ AAL+HD+EHTGTTNNFHV + S+  +LYND+ VLENHH SA FRL+++   N++ ++ +E++RE R +VIEMVL TDM+ HF+QMK+M+ +L L+E  IDK   LS +LHC DISHPAK W +H+RWT  LLEEFFRQGD E +L +PFSPLCDR + ++ ESQ+ F +FIVEPS  ++ +MLE I+ 
Sbjct:  334 VQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDR--------------MYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILA 692

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BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0344148)

HSP 1 Score: 386.341 bits (991), Expect = 3.235e-124
Identity = 183/374 (48.93%), Postives = 261/374 (69.79%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFS--TSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEE-NIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIG 1465
            V  DAVP E+REWL STF+   + SR    EKPKFR+VA+AIRAGI V++              ++++ +  A    P D+ + L+ ++++W+FD+F L + + G  ++++  +LF RY  IHK+KI     + F   +E+GY +Y NPYHN +H  DV QT+H+ +    L NWLTD++IFA++ AAL+HD+EHTGTTNNFHV + S+  +LYND+ VLENHH SA FRL+++   N++ ++ +E++RE R +VIEMVL TDM+ HF+QMK+M+ +L L+E  IDK   LS +LHC DISHPAK W +H+RWT  LLEEFFRQGD E +L +PFSPLCDR + ++ ESQ+ F +FIVEPS  ++ +MLE I+ 
Sbjct:  355 VQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDR--------------MYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILA 713

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BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde1a (phosphodiesterase 1A, calmodulin-dependent [Source:ZFIN;Acc:ZDB-GENE-090831-2])

HSP 1 Score: 411.379 bits (1056), Expect = 1.398e-136
Identity = 204/444 (45.95%), Postives = 307/444 (69.14%), Query Frame = 2

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIK 1489
            R K + ++     R+R ++K +    +   DL K++ Y   +++A+      ++   ED+  ++  D+VP E+R+WL STF+     V R   EKP+FR++ +A++AGI VE+              ++++++ +A L  P  +   L+ D+++WSFD+FKL + S  HAL+F+  +L  RY+ I +++I +    +F +ALE GYSK+ NPYHNL+H ADV QT H+++    + +WLT+++I A +FAA IHDFEHTGTTNNFH+ T S++ ILYND+ VLENHHVSA +RLMQ+  MN++ N+ K+D+RE R++VIEMV++TDMS HF+Q+K+M++ L   E IDK  ALS +LH ADISHPAK W LHYRWT  L+EEFFRQGD+E++L +PFSPLCDRK+ MI +SQ+GF +FIVEP+F++L +  E II  + ++ +K
Sbjct:   29 RLKGMQKYKNTSQRLRCLVKQLDKGEVNVVDLRKNIEYAASVLEAVYIDETRRLLDTEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMAGLTYPPSVITALK-DVDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVSFVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSAAYRLMQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEGIDKAKALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLVDTTEKIISPLIEEAVK 457

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BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde1a (phosphodiesterase 1A, calmodulin-dependent [Source:ZFIN;Acc:ZDB-GENE-090831-2])

HSP 1 Score: 409.068 bits (1050), Expect = 5.079e-136
Identity = 202/431 (46.87%), Postives = 302/431 (70.07%), Query Frame = 2

Query:  209 RVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIK 1489
            R+R ++K +    +   DL K++ Y   +++A+      ++   ED+  ++  D+VP E+R+WL STF+     V R   EKP+FR++ +A++AGI VE+              ++++++ +A L  P  +   L+ D+++WSFD+FKL + S  HAL+F+  +L  RY+ I +++I +    +F +ALE GYSK+ NPYHNL+H ADV QT H+++    + +WLT+++I A +FAA IHDFEHTGTTNNFH+ T S++ ILYND+ VLENHHVSA +RLMQ+  MN++ N+ K+D+RE R++VIEMV++TDMS HF+Q+K+M++ L   E IDK  ALS +LH ADISHPAK W LHYRWT  L+EEFFRQGD+E++L +PFSPLCDRK+ MI +SQ+GF +FIVEP+F++L +  E II  + ++ +K
Sbjct:   18 RLRCLVKQLDKGEVNVVDLRKNIEYAASVLEAVYIDETRRLLDTEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMAGLTYPPSVITALK-DVDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVSFVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSAAYRLMQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEGIDKAKALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLVDTTEKIISPLIEEAVK 433

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BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: CABZ01067973.1 (phosphodiesterase 1C, calmodulin-dependent b [Source:NCBI gene;Acc:100536162])

HSP 1 Score: 402.519 bits (1033), Expect = 3.802e-133
Identity = 204/436 (46.79%), Postives = 303/436 (69.50%), Query Frame = 2

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQP-HMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFII 1462
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +D+VP E+R+WL STF+     + R   EKP+FR++ +A++AGI VE+              ++++++ +  L  P ++   L+ +++ WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSKY NPYHNL+H ADV QTVH+++    + +W+T+++IFA IFAA IHD+EHTGTTNNFH+ T SD  ILYND+ VLE+HHVSA +RL+Q    MN++ N+ K+D+REFR++V+EMVL TDMS HF+Q+K+MK+ L   E IDK  A+S +LH ADISHPAK WDLH+RWTT LLEEFF QGD+E++L +PFSPLCDRKS M+ +SQ+GF +FIV P+F +L +M E I+
Sbjct:   30 RLRGLRKYKKTSQRLRCLVKQLERGEASLVDLKKNLEYAATVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRTEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPNVIAVLK-NVDRWSFDVFALNESSGDHALKFIFYELLTRYDLISRFKIPVSALVSFVEALEVGYSKYKNPYHNLIHAADVTQTVHYLLLKTGMVHWMTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSDAAILYNDRSVLESHHVSASYRLLQDDDEMNILYNLSKDDWREFRALVVEMVLATDMSCHFQQVKAMKNYLQQPEGIDKPKAISLLLHAADISHPAKTWDLHHRWTTSLLEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVVPTFTVLTDMTEKIV 450

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BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde4ba (phosphodiesterase 4B, cAMP-specific a [Source:ZFIN;Acc:ZDB-GENE-030131-9570])

HSP 1 Score: 206.453 bits (524), Expect = 1.354e-59
Identity = 110/292 (37.67%), Postives = 176/292 (60.27%), Query Frame = 2

Query:  608 DINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSM-----------LALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNML 1450
            D+N W  +IF + + S    L  I   +F   + +  +KI    F  +   LED Y +    YHN +H ADVAQ+ H ++ T  L+   TD++I AAIFAA IHD +H G +N F +NTNS+L ++YND+ VLENHH++  F+L+Q+ + ++ +N+ K+     R +VI+MVL TDMS H   +  +K+M           L L+   D+   L  ++HCAD+S+P K  +L+ +WT +++EEFF QGD+E +  +  SP+CD+ +  + +SQVGF ++IV P +    +++
Sbjct:  110 DLNRWGLNIFTVSEYSNNRPLTCIMYAIFQERDLLKTFKIPTDTFVTYMMTLEDHYHQ-DVAYHNSLHAADVAQSTHILLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLTKKQRTSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFHQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV 400

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BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde4bb (phosphodiesterase 4B, cAMP-specific b [Source:ZFIN;Acc:ZDB-GENE-070912-454])

HSP 1 Score: 210.305 bits (534), Expect = 1.364e-59
Identity = 112/283 (39.58%), Postives = 174/283 (61.48%), Query Frame = 2

Query:  608 DINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSM-----------LALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEP 1423
            DIN+W  +IFK+ + S    L  I   +F   + +  +KI +  F  +   LED Y      YHN +H ADVAQ+ H ++ T  L+   TD++I AA+FAA IHD +H G +N F +NTNS+L ++YND+ VLENHH++  F+L+Q  + +L +N+ K++ +  R +VI MVL TDMS H   +  +K+M           L L+   D+   L  ++HCAD+S+P K  DL+ +WT ++++EFF QGD+E +  +  SP+CD+ +  + +SQVGF ++IV P
Sbjct:  341 DINKWGLNIFKVAEHSHHRPLACIMYAIFQERDLMKTFKIPVDTFVTYMMTLEDHY-HADVAYHNSLHAADVAQSTHILLSTPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQGENCDLFQNLSKKERQTLRKMVIHMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKPLDLYKQWTDRIMQEFFHQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHP 622

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BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: arhgef39 (Rho guanine nucleotide exchange factor 39 [Source:Xenbase;Acc:XB-GENE-6257690])

HSP 1 Score: 408.297 bits (1048), Expect = 2.863e-136
Identity = 197/381 (51.71%), Postives = 276/381 (72.44%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIK 1489
            ++TD+VP E+R+WL STF+       R   EKPKFR++ +A++AGI VE+              ++++S+ IA L  P+ +   ++ D++ W+F++F L++ SG HAL+F+  +LF RY+  +++KI +    +F +ALE GYSKY NPYHNLVH ADV QTVH++I    + +WLT+++I A IFAA IHDFEHTGTTNNFH+ T SD+ ILYND+ VLENHHVSA +R+MQ   MN+  N+ K+D+R+ R++VIEMVL+TDMS HF+Q+K+M+S L   E IDK  A+S ILH ADISHPAK WD+H RWT  L+EEFFRQGD+E+ L +PFSPLCDRKS M+ +SQ+GF +FIVEP+F +L +  E I+  + ++  K
Sbjct:   84 IHTDSVPLEVRDWLASTFTRKMGMRKRRPEEKPKFRSIVHAVQAGIFVER--------------MYRRSSNIAGLTYPSSVIASMK-DVDRWAFNVFTLNEASGEHALKFMVYELFTRYDLTNRFKIPVSNLVSFVEALEVGYSKYKNPYHNLVHAADVTQTVHYIILHTGIMHWLTELEILAMIFAAAIHDFEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRIMQDDEMNIFINLSKDDWRDLRTLVIEMVLSTDMSGHFQQLKTMRSTLQQPEGIDKAKAMSLILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEAALGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTLLTDSTEKIVFPLIEEAAK 449

[Close]

BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: arhgef39 (Rho guanine nucleotide exchange factor 39 [Source:Xenbase;Acc:XB-GENE-6257690])

HSP 1 Score: 408.297 bits (1048), Expect = 3.305e-136
Identity = 197/381 (51.71%), Postives = 276/381 (72.44%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIK 1489
            ++TD+VP E+R+WL STF+       R   EKPKFR++ +A++AGI VE+              ++++S+ IA L  P+ +   ++ D++ W+F++F L++ SG HAL+F+  +LF RY+  +++KI +    +F +ALE GYSKY NPYHNLVH ADV QTVH++I    + +WLT+++I A IFAA IHDFEHTGTTNNFH+ T SD+ ILYND+ VLENHHVSA +R+MQ   MN+  N+ K+D+R+ R++VIEMVL+TDMS HF+Q+K+M+S L   E IDK  A+S ILH ADISHPAK WD+H RWT  L+EEFFRQGD+E+ L +PFSPLCDRKS M+ +SQ+GF +FIVEP+F +L +  E I+  + ++  K
Sbjct:   84 IHTDSVPLEVRDWLASTFTRKMGMRKRRPEEKPKFRSIVHAVQAGIFVER--------------MYRRSSNIAGLTYPSSVIASMK-DVDRWAFNVFTLNEASGEHALKFMVYELFTRYDLTNRFKIPVSNLVSFVEALEVGYSKYKNPYHNLVHAADVTQTVHYIILHTGIMHWLTELEILAMIFAAAIHDFEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRIMQDDEMNIFINLSKDDWRDLRTLVIEMVLSTDMSGHFQQLKTMRSTLQQPEGIDKAKAMSLILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEAALGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTLLTDSTEKIVFPLIEEAAK 449

[Close]

BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:100495383])

HSP 1 Score: 404.445 bits (1038), Expect = 4.814e-135
Identity = 204/443 (46.05%), Postives = 295/443 (66.59%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKD-------GIKLEIAENISIAQNAPVKGSI--------HFPWEAKIVNNRSTWQKQIDQRKEELN 1627
            + +D+VP E+R+WL STF+     + +   EKP+FR++ +A++AGI VE+               + K++ +  L  P  +   L+ ++++WSFD+F L+D SG H L+FI  +L  RY+ I+++KI +    +F +ALE GY+K+ NPYHNL+H ADV QTVH+ ++   L +WLT+++IFA IFAA +HD+EHTGTTNNFH+ T SD  ILYND+ VLENHHVSA +RL+Q    MN++ N+ K+D+REFR++VIEMVL TDMS HF Q+K MK+ L   E IDK  ALS +LH ADISHPAK+WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDR S M+ +SQ+GF +FIVEP+F +L +M+E I+  + ++       G +    ++     +A +  SI           W   ++ NR  W+ Q   + ++L 
Sbjct:   84 IQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPRFRSIVHAVQAGIFVER---------------YGKTSNMVGLSYPPAVIAVLK-NVDKWSFDVFALNDASGDHGLKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYTKHKNPYHNLIHAADVTQTVHYFLFKSGLVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLLQDDEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQIKQMKNALQQPEGIDKPKALSLLLHTADISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNSTMVAQSQIGFIDFIVEPTFTVLTDMIEKIVVPLIEEASRSGLTGFRRSSVKSTGSEGSASLNCSILTVDFKSFKCTWYDVVLQNREKWKTQASVKSQDLQ 510

[Close]

BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:100495383])

HSP 1 Score: 403.29 bits (1035), Expect = 1.630e-134
Identity = 193/373 (51.74%), Postives = 273/373 (73.19%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFII 1462
            + +D+VP E+R+WL STF+     + +   EKP+FR++ +A++AGI VE+              ++++++ +  L  P  +   L+ ++++WSFD+F L+D SG H L+FI  +L  RY+ I+++KI +    +F +ALE GY+K+ NPYHNL+H ADV QTVH+ ++   L +WLT+++IFA IFAA +HD+EHTGTTNNFH+ T SD  ILYND+ VLENHHVSA +RL+Q    MN++ N+ K+D+REFR++VIEMVL TDMS HF Q+K MK+ L   E IDK  ALS +LH ADISHPAK+WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDR S M+ +SQ+GF +FIVEP+F +L +M+E I+
Sbjct:   84 IQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIAVLK-NVDKWSFDVFALNDASGDHGLKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYTKHKNPYHNLIHAADVTQTVHYFLFKSGLVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLLQDDEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQIKQMKNALQQPEGIDKPKALSLLLHTADISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNSTMVAQSQIGFIDFIVEPTFTVLTDMIEKIV 441

[Close]

BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:100495383])

HSP 1 Score: 402.905 bits (1034), Expect = 2.085e-134
Identity = 193/373 (51.74%), Postives = 273/373 (73.19%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFII 1462
            + +D+VP E+R+WL STF+     + +   EKP+FR++ +A++AGI VE+              ++++++ +  L  P  +   L+ ++++WSFD+F L+D SG H L+FI  +L  RY+ I+++KI +    +F +ALE GY+K+ NPYHNL+H ADV QTVH+ ++   L +WLT+++IFA IFAA +HD+EHTGTTNNFH+ T SD  ILYND+ VLENHHVSA +RL+Q    MN++ N+ K+D+REFR++VIEMVL TDMS HF Q+K MK+ L   E IDK  ALS +LH ADISHPAK+WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDR S M+ +SQ+GF +FIVEP+F +L +M+E I+
Sbjct:   84 IQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIAVLK-NVDKWSFDVFALNDASGDHGLKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYTKHKNPYHNLIHAADVTQTVHYFLFKSGLVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLLQDDEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQIKQMKNALQQPEGIDKPKALSLLLHTADISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNSTMVAQSQIGFIDFIVEPTFTVLTDMIEKIV 441

[Close]

BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde1c (phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:108413])

HSP 1 Score: 414.461 bits (1064), Expect = 1.561e-137
Identity = 208/439 (47.38%), Postives = 306/439 (69.70%), Query Frame = 2

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  +   L+ D++ WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q+   MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIDALK-DVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

[Close]

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  +   L+ D++ WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q+   MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIDALK-DVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

[Close]

BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde1c (phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:108413])

HSP 1 Score: 414.461 bits (1064), Expect = 2.860e-137
Identity = 208/439 (47.38%), Postives = 306/439 (69.70%), Query Frame = 2

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  +   L+ D++ WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q+   MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIDALK-DVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

[Close]

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  +   L+ D++ WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q+   MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIDALK-DVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

[Close]

BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde1c (phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:108413])

HSP 1 Score: 412.535 bits (1059), Expect = 4.392e-137
Identity = 206/433 (47.58%), Postives = 303/433 (69.98%), Query Frame = 2

Query:  188 QFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  +   L+ D++ WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q+   MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:    8 KYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIDALK-DVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 425

[Close]

BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q14123|PDE1C_HUMAN (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C OS=Homo sapiens OX=9606 GN=PDE1C PE=1 SV=1)

HSP 1 Score: 415.231 bits (1066), Expect = 5.589e-136
Identity = 208/439 (47.38%), Postives = 307/439 (69.93%), Query Frame = 2

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  + + L+ D+++WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q    MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIEALK-DVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

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BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q64338|PDE1C_MOUSE (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C OS=Mus musculus OX=10090 GN=Pde1c PE=1 SV=2)

HSP 1 Score: 414.461 bits (1064), Expect = 9.372e-136
Identity = 208/439 (47.38%), Postives = 306/439 (69.70%), Query Frame = 2

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  +   L+ D++ WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q+   MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   30 RLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIDALK-DVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 453

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BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q63421|PDE1C_RAT (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C OS=Rattus norvegicus OX=10116 GN=Pde1c PE=1 SV=1)

HSP 1 Score: 413.305 bits (1061), Expect = 1.612e-134
Identity = 206/432 (47.69%), Postives = 302/432 (69.91%), Query Frame = 2

Query:  191 FIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM 1471
             ++   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +DAVP E+R+WL STF+     + R   EKP+F+++ +A++AGI VE+              ++++++ +  L  P  +   L+ D++ WSFD+F L++ SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++Y   + NWLT+++IFA IF+A IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHH+SA +RL+Q+   MN++ N+ K+D+REFR++VIEMV+ TDMS HF+Q+K+MK+ L   E I+K  ALS +LH ADISHPAK WDLH+RWT  LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQVGF +FIVEP+F +L +M E I+  +
Sbjct:   97 LVKTSFRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPAVIDALK-DVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPL 513

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BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|P14100|PDE1A_BOVIN (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A OS=Bos taurus OX=9913 GN=PDE1A PE=1 SV=3)

HSP 1 Score: 395.201 bits (1014), Expect = 1.445e-130
Identity = 188/380 (49.47%), Postives = 276/380 (72.63%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLE-FIIGMMKKDG 1483
            + +D+VP E+R+WL STF+     + +   EKP+FR++ + ++AGI VE+              +++KS  +  L  P  +   L+ D+++WSFD+F L++ SG H+L+F+  +LF RY+ I+++KI +     F +ALE GYSKY NPYHNL+H ADV QTVH+++    + +WLT+++I A +FAA IHD+EHTGTTNNFH+ T SD+ ILYND+ VLENHHVSA +RLMQ+  MN++ N+ K+D+R+ R++VIEMVL+TDMS HF+Q+K++++ L   E +DK   +S ILH ADISHPAK W LH+RWT  L+EEFF QGD+E++L +PFSPLCDRKS M+ +SQ+GF +FIVEP+F++L +  E  II ++++D 
Sbjct:   84 IQSDSVPSEVRDWLASTFTRKMGMMKKKSEEKPRFRSIVHVVQAGIFVER--------------MYRKSYHMVGLAYPEAVIVTLK-DVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNVLINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGLDKAKTMSLILHAADISHPAKSWKLHHRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIIIPLIEEDS 448

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BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|P54750|PDE1A_HUMAN (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A OS=Homo sapiens OX=9606 GN=PDE1A PE=1 SV=2)

HSP 1 Score: 393.275 bits (1009), Expect = 1.093e-129
Identity = 192/396 (48.48%), Postives = 282/396 (71.21%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFS--TSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPV 1534
            + TD+VP E+R+WL STF+     ++    EKPKFR++ +A++AGI VE+              +++K+  +  L  P  +   L+ D+++WSFD+F L++ SG H+L+F+  +LF RY+ I+++KI +     F +ALE GYSKY NPYHNL+H ADV QTVH+++    + +WLT+++I A +FAA IHD+EHTGTTNNFH+ T SD+ ILYND+ VLENHHVSA +RLMQ+  MN++ N+ K+D+R+ R++VIEMVL+TDMS HF+Q+K++++ L   E ID+   +S ILH ADISHPAK W LHYRWT  L+EEFF QGD+E++L +PFSPLCDRKS M+ +SQ+GF +FIVEP+F++L +  E I+  + ++  K E +  ++ +    V
Sbjct:   84 IQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVER--------------MYRKTYHMVGLAYPAAVIVTLK-DVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIV 464

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BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A267DMF6 (Phosphodiesterase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013692g1 PE=3 SV=1)

HSP 1 Score: 470.315 bits (1209), Expect = 2.132e-157
Identity = 242/514 (47.08%), Postives = 358/514 (69.65%), Query Frame = 2

Query:  101 ITEMPSSKADDAILGSVRGTSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXXXXXXXXXXXXX--XXXVNTDAVPGEIREWLTSTFSTSASRVSR-IEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM----KKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQIDQRKEE 1621
            + + PS++  ++ LG+ R  S    +A      C +R++++ +L+  D I KE L+++L Y V++++A+  +E   +  +D     V+ + VP E+R+WL STF+ S + + +  EKP FR+VANAIRAGIMVE+              I+++ +  +++ +P ++   L++ ++EW FD+F+L+++S  HA++F+G +L  +Y+ I K+KIN    +NF    E+GYSK+GNPYHNLVHGADVAQT HF+++  +L NWLTD++IFA I AALIHD+EHTGTTNNFH+N NSDL +LYNDKGVLEN+HVSA F LM++   N++  + +E+Y+EFR++VI+MVLNTDMS HF+Q+K+MK +L++ E IDK  AL+ +LHCADISHP K WDLHYRWT  LLEEFFRQGD+E  L++P SPLCDR   M+ +SQVGF +FI+EPSFN+LG+MLE I+G +    +K G      ++ S +++     SI  PW   I  NR+TW+ + +  + E
Sbjct:   22 LQKAPSTQYAESELGTERMPSVGTPEA---SFACSVRLKKIARLVEEDTINKELLVQNLRYAVQVLEAVYEDETKRLCNEDDDLPEVSPNEVPSEVRDWLASTFTRSQTSLKQNKEKPHFRSVANAIRAGIMVER--------------IYRRLSSSSSISVPPNVLLLLKAGLDEWCFDVFELNEVSENHAMKFVGFELLHKYDLISKFKINSSVLENFLYKCEEGYSKWGNPYHNLVHGADVAQTCHFIMHDSKLVNWLTDLEIFATIIAALIHDYEHTGTTNNFHINMNSDLALLYNDKGVLENYHVSAIFTLMREDDYNILTGLTREEYKEFRALVIDMVLNTDMSLHFQQIKNMKQLLSMPEKIDKEKALALMLHCADISHPGKRWDLHYRWTLGLLEEFFRQGDRERALDLPCSPLCDRTVTMVAQSQVGFIDFIMEPSFNVLGDMLEKILGPLFEQQRKAGGSAGPDDDGSASESG--SPSIRRPWADVIKENRATWKARAEIEEAE 516

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BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A267DMU5 (Phosphodiesterase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013692g2 PE=3 SV=1)

HSP 1 Score: 473.396 bits (1217), Expect = 4.059e-157
Identity = 243/514 (47.28%), Postives = 359/514 (69.84%), Query Frame = 2

Query:  101 ITEMPSSKADDAILGSVRGTSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXXXXXXXXXXXXX--XXXVNTDAVPGEIREWLTSTFSTSASRVSR-IEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM----KKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQIDQRKEE 1621
            + + PS++  ++ LG+ R  S    +A      C +R++++ +L+  D I KE L+++L Y V++++A+  +E   +  +D     V+ + VP E+R+WL STF+ S + + +  EKP FR+VANAIRAGIMVE+              I+++ +  +++ +P ++   L++ ++EW FD+F+L+++S  HA++F+G +L  +Y+ I K+KIN    +NF    E+GYSK+GNPYHNLVHGADVAQT HF+++  +L NWLTD++IFA I AALIHD+EHTGTTNNFH+NTNSDL +LYNDKGVLEN+HVSA F LM++   N++  + +E+Y+EFR++VI+MVLNTDMS HF+Q+K+MK +L++ E IDK  AL+ +LHCADISHP K WDLHYRWT  LLEEFFRQGD+E  L++P SPLCDR   M+ +SQVGF +FI+EPSFN+LG+MLE I+G +    +K G      ++ S +++     SI  PW   I  NR+TW+ + +  + E
Sbjct:  125 LQKAPSTQYAESELGTERMPSVGTPEA---SFACSVRLKKIARLVEEDTINKELLVQNLRYAVQVLEAVYEDETKRLCNEDDDLPEVSPNEVPSEVRDWLASTFTRSQTSLKQNKEKPHFRSVANAIRAGIMVER--------------IYRRLSSSSSISVPPNVLLLLKAGLDEWCFDVFELNEVSENHAMKFVGFELLHKYDLISKFKINSSVLENFLYKCEEGYSKWGNPYHNLVHGADVAQTCHFIMHDSKLVNWLTDLEIFATIIAALIHDYEHTGTTNNFHINTNSDLALLYNDKGVLENYHVSAIFTLMREDDYNILTGLTREEYKEFRALVIDMVLNTDMSLHFQQIKNMKQLLSMPEKIDKEKALALMLHCADISHPGKRWDLHYRWTLGLLEEFFRQGDRERALDLPCSPLCDRTVTMVAQSQVGFIDFIMEPSFNVLGDMLEKILGPLFEQQRKAGGSAGPDDDGSASESG--SPSIRRPWADVIKENRATWKARAEIEEAE 619

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BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A1I8J257 (Phosphodiesterase OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 463.381 bits (1191), Expect = 7.843e-155
Identity = 236/476 (49.58%), Postives = 337/476 (70.80%), Query Frame = 2

Query:  200 CCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSR-IEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM----KKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQID 1606
            C IR+R++ KL+ SDGI K+ LIK+L Y  ++++++      ++   ED+   V +  VP E+R+WL STF+ S + + +  EKPKFR+VANAIRAGIMVE+ + S  I+                  +P ++   L++ +++W F+IF+L++ S  HAL+F+G +L  +Y+ I+K+KIN    +NF    E+GYS++ NPYHNLVHGADVAQT HF++ + +L NWLTD++IFA IFAA+IHD+EHTGTTNNFHVNT S+L +LYNDKGVLENHH SA FRLM+    N++  + +E+Y+EFR++VI+MVLNTDMS HF+Q+K+MK +L++ ENIDK  AL+ +LHCADISHP K +DLH RWT  LLEEFFRQGD+E  L++P SPLCDR + M+ +SQVGF +FI+EPSF +LG+MLE I+  +    ++ G +  + E    A+ A V   +H PW   +  NR+ W+++ D
Sbjct:   13 CSIRLRKIAKLVASDGISKDALIKNLTYAAQVLESVYLDETRRLCNEEDELPEVPSGEVPNEVRDWLASTFTRSQTSLKQHREKPKFRSVANAIRAGIMVERLSSSSNIN------------------VPQNVLVLLKAGLDDWCFNIFELNEASDNHALKFVGFELLHKYDLINKFKINTNVLENFLTKCEEGYSRFSNPYHNLVHGADVAQTCHFIMSSSKLVNWLTDLEIFATIFAAIIHDYEHTGTTNNFHVNTASELALLYNDKGVLENHHASAVFRLMKLDEFNIISGLSREEYKEFRALVIDMVLNTDMSLHFQQIKNMKQLLSMPENIDKEKALALMLHCADISHPGKRFDLHQRWTMSLLEEFFRQGDREKALDLPCSPLCDRSTTMVAQSQVGFIDFIMEPSFGVLGDMLEKILMPLFEQQRQHGTRNPVDE--GGAEGAFV---LHRPWNEHLKTNRALWKEKAD 465

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BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A267EML7 (Phosphodiesterase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011124g1 PE=3 SV=1)

HSP 1 Score: 463.766 bits (1192), Expect = 2.549e-151
Identity = 234/476 (49.16%), Postives = 339/476 (71.22%), Query Frame = 2

Query:  200 CCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXXXXXXXXXXXXXX--XXVNTDAVPGEIREWLTSTFSTSASRVSRI-EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM--KKDGIKLEIAENISIAQNAPVK---GSIHF----PWEAKIVNNRSTW 1591
            C +R++++ KL+ SD I KE LIK+L Y V++++++  +E   +  +D+    V  + VP E+R+WL STF+ S + + +  EKP+FR+VANAIRAGIMVE+              I+++ +  + + +P ++   L++ +++W FDIF+L++ S  HA++F+G +L  +Y+ I+K+KIN    +NF   LE+GYSK+ NPYHNLVHGADVAQT HF++ + +L NWLTD++IFA I AAL+HD+EHTGTTN+FHVNT SDL +LYNDKGVLEN+HVSA FRL+++   N++  + +E+Y+EFR++VI+MVLNTDMS HF+Q+K+MK +L++ ENIDK  AL+ +LHCADISHP K W+LH+RWT  LLEEFFRQGD+E  L++P SPLCDR S M+ +SQVGF +FI+EPSF +LG+MLE I+  +  ++  +    +E      + PV+   G   F    PW   I  NRS W
Sbjct:  258 CSVRLKKIAKLVESDEISKEMLIKNLNYAVKVLESVYVDETRRLCNEDDDLPEVPPNEVPNEVRDWLASTFTRSQTSLKQSREKPRFRSVANAIRAGIMVER--------------IYRRLSSSSNISVPPNVLILLKAGLDDWCFDIFELNEASDNHAMKFVGYELLHKYDLINKFKINTNVLENFLYKLEEGYSKWANPYHNLVHGADVAQTCHFIMSSSKLVNWLTDLEIFATIVAALVHDYEHTGTTNSFHVNTGSDLALLYNDKGVLENYHVSAVFRLLREEDYNILTGLSREEYKEFRALVIDMVLNTDMSLHFQQIKNMKQLLSMPENIDKEKALALMLHCADISHPGKRWNLHHRWTMSLLEEFFRQGDREKALDLPCSPLCDRSSTMVAQSQVGFIDFIMEPSFAVLGDMLEKILTPLFEQQKQLSKNPSEEAGARISRPVRKWHGDGGFCLPRPWNDIIKENRSQW 719

[Close]

BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A267EIK0 (Phosphodiesterase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011124g2 PE=3 SV=1)

HSP 1 Score: 463.381 bits (1191), Expect = 3.755e-151
Identity = 234/476 (49.16%), Postives = 338/476 (71.01%), Query Frame = 2

Query:  200 CCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXXXXXXXXXXXXXX--XXVNTDAVPGEIREWLTSTFSTSASRVSRI-EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM--KKDGIKLEIAENISIAQNAPVK---GSIHF----PWEAKIVNNRSTW 1591
            C +R++++ KL+ SD I KE LIK+L Y V++++++  +E   +  +D+    V  + VP E+R+WL STF+ S + + +  EKP+FR+VANAIRAGIMVE+              I+++ +  + + +P ++   L++ +++W FDIF+L++ S  HA++F+G +L  +Y+ I K+KIN    +NF   LE+GYSK+ NPYHNLVHGADVAQT HF++ + +L NWLTD++IFA I AAL+HD+EHTGTTN+FHVNT SDL +LYNDKGVLEN+HVSA FRL+++   N++  + +E+Y+EFR++VI+MVLNTDMS HF+Q+K+MK +L++ ENIDK  AL+ +LHCADISHP K W+LH+RWT  LLEEFFRQGD+E  L++P SPLCDR S M+ +SQVGF +FI+EPSF +LG+MLE I+  +  ++  +    +E      + PV+   G   F    PW   I  NRS W
Sbjct:  258 CSVRLKKIAKLVESDEISKEMLIKNLNYAVKVLESVYVDETRRLCNEDDDLPEVPPNEVPNEVRDWLASTFTRSQTSLKQSREKPRFRSVANAIRAGIMVER--------------IYRRLSSSSNISVPPNVLILLKAGLDDWCFDIFELNEASDNHAMKFVGYELLHKYDLITKFKINTNVLENFLYKLEEGYSKWANPYHNLVHGADVAQTCHFIMSSSKLVNWLTDLEIFATIVAALVHDYEHTGTTNSFHVNTGSDLALLYNDKGVLENYHVSAVFRLLREEDYNILTGLSREEYKEFRALVIDMVLNTDMSLHFQQIKNMKQLLSMPENIDKEKALALMLHCADISHPGKRWNLHHRWTMSLLEEFFRQGDREKALDLPCSPLCDRSSTMVAQSQVGFIDFIMEPSFAVLGDMLEKILTPLFEQQKQLSKNPSEEAGARISRPVRKWHGDGGFCLPRPWNDIIKENRSQW 719

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BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:103040750])

HSP 1 Score: 401.749 bits (1031), Expect = 7.673e-134
Identity = 212/484 (43.80%), Postives = 313/484 (64.67%), Query Frame = 2

Query:  200 CCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQP-HMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMM------------KKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQ 1600
            C   +R ++K +        DL K+L Y   +++++      ++   ED+  ++ +D+VP E+R+WL STF+     + R   EKP+FR++ +A++AGI VE+              ++++++ +  L  P  +   L+  ++ WSFD+F L++ SG HAL+FI  +L  RY+ I+++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++    + +WLT+++IFA IFAA +HD+EHTGTTNNFH+ T SD  ILYND+ V ENHHVSA +RL+Q    MN++ N+ K+D+RE R++V+EMVL TDMS HF+Q+K+MK+ L   E IDK  ALS +LH ADISHPAK WDLH+ WTT LLEEFFRQGD+ES L +PFSPLCDRKS M+ +SQ+GF +FIVEP+F +L +M E I+  +            ++  +K   +E  +   +   K S    W  ++  NR  W+ Q
Sbjct:   38 CSEMLRCLVKQLERGEASVVDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPSVITVLKH-VDTWSFDVFALNEASGDHALKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKSGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDAAILYNDRAVQENHHVSAAYRLLQDDDEMNILYNLSKDDWRELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEAIDKPKALSLLLHTADISHPAKRWDLHHHWTTSLLEEFFRQGDKESDLGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVLTDMTEKIVTPLIDEASSSGLAGFRRSSVKSTGSEGSTSLLSVDFK-SFKATWNDEVHQNREKWKAQ 505

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BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:103040750])

HSP 1 Score: 403.29 bits (1035), Expect = 1.912e-132
Identity = 205/436 (47.02%), Postives = 300/436 (68.81%), Query Frame = 2

Query:  170 RDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQP-HMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFII 1462
            R + L ++ +   R+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +D+VP E+R+WL STF+     + R   EKP+FR++ +A++AGI VE+              ++++++ +  L  P  +   L+  ++ WSFD+F L++ SG HAL+FI  +L  RY+ I+++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++    + +WLT+++IFA IFAA +HD+EHTGTTNNFH+ T SD  ILYND+ V ENHHVSA +RL+Q    MN++ N+ K+D+RE R++V+EMVL TDMS HF+Q+K+MK+ L   E IDK  ALS +LH ADISHPAK WDLH+ WTT LLEEFFRQGD+ES L +PFSPLCDRKS M+ +SQ+GF +FIVEP+F +L +M E I+
Sbjct:   40 RLRGLRKYKKTSQRLRCLVKQLERGEASVVDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPSVITVLKH-VDTWSFDVFALNEASGDHALKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKSGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDAAILYNDRAVQENHHVSAAYRLLQDDDEMNILYNLSKDDWRELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEAIDKPKALSLLLHTADISHPAKRWDLHHHWTTSLLEEFFRQGDKESDLGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVLTDMTEKIV 460

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BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: ENSAMXT00000048550.1 (pep primary_assembly:Astyanax_mexicanus-2.0:17:4377033:4466642:1 gene:ENSAMXG00000041175.1 transcript:ENSAMXT00000048550.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 399.438 bits (1025), Expect = 1.954e-132
Identity = 192/373 (51.47%), Postives = 272/373 (72.92%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQP-HMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFII 1462
            + +D+VP E+R+WL STF+     + R   EKP+FR++ +A++AGI VE+              ++++++ +  L  P  +   L+  +++WSFD+F L+D SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++    + +WLT+++IFA IFAA +HD+EHTGTTNNFH+ T SD  ILYND+ VLE+HHVSA +RL+Q    MN++ N+ K+D+REFR++V+EMVL TDMS HF+Q+K+MK+ L   E IDK  ALS +LH ADISHPAK+WDLH+RWT  LLEEFF QGD+E++L +PFSPLCDRKS M+ +SQ+GF +FIV P+F +L +M E I+
Sbjct:   55 IQSDSVPSEVRDWLASTFTRQMGLMLRKTEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPASVITVLKH-VDKWSFDVFALNDASGDHALKFIFYELLTRYDLISRFKIPISSLVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDTAILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDWREFRALVVEMVLATDMSCHFQQVKAMKNFLQQPEGIDKSKALSLLLHTADISHPAKNWDLHHRWTASLLEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVVPTFTVLTDMTEKIV 412

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BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:103040750])

HSP 1 Score: 404.06 bits (1037), Expect = 2.109e-132
Identity = 204/427 (47.78%), Postives = 296/427 (69.32%), Query Frame = 2

Query:  197 ECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXX--XXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQP-HMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFII 1462
            +  IR+R ++K +        DL K+L Y   +++++      ++   ED+  ++ +D+VP E+R+WL STF+     + R   EKP+FR++ +A++AGI VE+              ++++++ +  L  P  +   L+  ++ WSFD+F L++ SG HAL+FI  +L  RY+ I+++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++    + +WLT+++IFA IFAA +HD+EHTGTTNNFH+ T SD  ILYND+ V ENHHVSA +RL+Q    MN++ N+ K+D+RE R++V+EMVL TDMS HF+Q+K+MK+ L   E IDK  ALS +LH ADISHPAK WDLH+ WTT LLEEFFRQGD+ES L +PFSPLCDRKS M+ +SQ+GF +FIVEP+F +L +M E I+
Sbjct:   97 KTAIRLRCLVKQLERGEASVVDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPSVITVLKH-VDTWSFDVFALNEASGDHALKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKSGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDAAILYNDRAVQENHHVSAAYRLLQDDDEMNILYNLSKDDWRELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEAIDKPKALSLLLHTADISHPAKRWDLHHHWTTSLLEEFFRQGDKESDLGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVLTDMTEKIV 508

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BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: ENSAMXT00000040842.1 (pep primary_assembly:Astyanax_mexicanus-2.0:17:4377033:4466473:1 gene:ENSAMXG00000041175.1 transcript:ENSAMXT00000040842.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 399.438 bits (1025), Expect = 2.317e-132
Identity = 192/373 (51.47%), Postives = 272/373 (72.92%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQP-HMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFII 1462
            + +D+VP E+R+WL STF+     + R   EKP+FR++ +A++AGI VE+              ++++++ +  L  P  +   L+  +++WSFD+F L+D SG HAL+FI  +L  RY+ I ++KI +    +F +ALE GYSK+ NPYHNL+H ADV QTVH+++    + +WLT+++IFA IFAA +HD+EHTGTTNNFH+ T SD  ILYND+ VLE+HHVSA +RL+Q    MN++ N+ K+D+REFR++V+EMVL TDMS HF+Q+K+MK+ L   E IDK  ALS +LH ADISHPAK+WDLH+RWT  LLEEFF QGD+E++L +PFSPLCDRKS M+ +SQ+GF +FIV P+F +L +M E I+
Sbjct:   55 IQSDSVPSEVRDWLASTFTRQMGLMLRKTEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPASVITVLKH-VDKWSFDVFALNDASGDHALKFIFYELLTRYDLISRFKIPISSLVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDTAILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDWREFRALVVEMVLATDMSCHFQQVKAMKNFLQQPEGIDKSKALSLLLHTADISHPAKNWDLHHRWTASLLEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVVPTFTVLTDMTEKIV 412

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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: pde1a (phosphodiesterase 1A, calmodulin-dependent [Source:ZFIN;Acc:ZDB-GENE-090831-2])

HSP 1 Score: 397.897 bits (1021), Expect = 3.491e-133
Identity = 198/447 (44.30%), Postives = 293/447 (65.55%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRS-DINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKL---EIAENISIA-------QNAPVKGSIHFPWEAKIVNNRSTWQKQIDQRKEELNKLEA--EPT 1648
            ++++AVP E+R+WL STF+      +R   +KP+FR++ +A++AGI VE+              ++++++ +  L  P ++   L++   ++WSFD+F L++ SG HAL+F+  +L  RY  I +YKI +    +F +ALE GYSK+ NPYHNL H ADV QTVH+++    L +WL++++  A IFAA IHD EHTGTTNNFH+ T SD+ +LYND+ VLENHHVSA +RLMQ   MN+  N+ K+D+RE R++V+EMVL TDMS HF+Q+K+MKS L   E+IDK  A+S +LH  DISHP K+W LH RWT  L+EEFFRQGD+E++L +PFSPLCDR S M+ +SQ+GF +FIVEP+F++L +M E ++  + ++  +     +    S A       + A   GS+       ++  R+ WQ  +   KE   +  A  EP+
Sbjct:   75 ISSEAVPAEVRDWLASTFTRRMGVTARRPEDKPRFRSIVHAVQAGIFVER--------------MYRRTSNMVGLSYPPNVLVALKNWTCHKWSFDVFVLNEASGEHALKFVMHELLTRYELISRYKIPVAALVSFVEALEAGYSKHKNPYHNLAHAADVTQTVHYLLLQSGLMHWLSELETLAVIFAAAIHDLEHTGTTNNFHIQTRSDVALLYNDRAVLENHHVSAAYRLMQDDDMNIFINLSKDDWRELRALVVEMVLATDMSCHFQQIKTMKSALQQPESIDKSKAMSLLLHAGDISHPTKEWPLHQRWTEALMEEFFRQGDREAKLGLPFSPLCDRNSTMVAQSQIGFMDFIVEPTFSVLTDMAEKVVVPLAEEAARAGTPGVPRRGSAATVEWHRGKRAASDGSVTSICTVDLLQFRALWQNCLSSNKERWKEQAAASEPS 507

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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 387.497 bits (994), Expect = 2.562e-130
Identity = 193/432 (44.68%), Postives = 296/432 (68.52%), Query Frame = 2

Query:  209 RVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXX--XXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQ-PHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIK 1489
            R+R ++K +    +   DL K+L Y   +++A+      ++   ED+  ++ +D VP E+R+WL STF+     + +   EKP+FR++ +A++AGI VE+              ++++++ +  L  P  +   L+ ++++WSFD+F L + SG HAL+FI  +LF RY+ I ++KI +    +F +ALE GYSK+ NPYHN VH ADV QTVH+++      +WL +++I + IFAA IHD+EHTGTTNNFH+ T SD  ILYND+ VLENHHVSA +RLMQ+   MN++ N+ K+D+RE R++V+E VL TDMS HF Q+KS+K++L   E ++K  A+S +LH ADISHPAK+W+LH RWT  L+EEFFRQGD+E++L + FSPLCDR + M+P+SQ+GF ++IVEP+F +L ++ EF++  +  +  +
Sbjct:   18 RLRCLVKQLERGELPVLDLRKNLEYAASVLEAVYIDETRRLLDTEDELSDLRSDTVPSEVRDWLASTFTRQMGLMLKRSEEKPRFRSIVHAVQAGIFVER--------------MYRRTSSMVGLSYPPAVISVLK-EVDKWSFDVFALHEASGEHALKFIVYELFTRYDLIARFKIPVSSVVSFVEALEAGYSKHKNPYHNSVHAADVTQTVHYLMLKTGTIHWLNELEILSMIFAAAIHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLMQEDEEMNILINLSKDDWRELRALVVETVLATDMSCHFHQLKSIKNLLQQPEGVEKPKAMSLMLHTADISHPAKNWNLHRRWTMSLMEEFFRQGDKEAELGLSFSPLCDRNATMVPQSQIGFIDYIVEPTFTVLTDLSEFVVAPLIDEAAR 434

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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003038.1 (pep scaffold:Pmarinus_7.0:GL476485:41:13228:1 gene:ENSPMAG00000002763.1 transcript:ENSPMAT00000003038.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 219.164 bits (557), Expect = 1.263e-67
Identity = 100/192 (52.08%), Postives = 136/192 (70.83%), Query Frame = 2

Query:  917 HDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPH-MNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIK 1489
            HD EHTGTTNNFH+ T SD+ ILYND+ V+ENHHVS  +R+MQ     N++ N+   DYR F + +I  VL    +  +KQ+   K +      IDK  A+S I+H +DISHPAK+W LH RWT  LLEEFF+QGD+E +L +PFSPLCDRKS M+P+SQVGF +FIVEP+ ++L +M+E I+  + K+ ++
Sbjct:    5 HDLEHTGTTNNFHIQTRSDVAILYNDRSVMENHHVSTAYRIMQADEDANILINLSNRDYRIFLTQLINYVLMPIFNCAYKQLHFQKKIYKEPRVIDKPKAMSLIVHTSDISHPAKEWRLHRRWTESLLEEFFQQGDREEELGLPFSPLCDRKSTMVPQSQVGFIDFIVEPTLSVLTDMVEGIVAPLVKEAVR 196

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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: pde7a (phosphodiesterase 7A [Source:ZFIN;Acc:ZDB-GENE-031222-10])

HSP 1 Score: 158.303 bits (399), Expect = 7.887e-44
Identity = 93/275 (33.82%), Postives = 144/275 (52.36%), Query Frame = 2

Query:  620 WSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTH---FKQMKSM--KSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSF 1429
            WSFD+F  D ++ G++L  +   LF  +  I  +++++     F   +++ Y    NPYHN VH ADV Q +H  +   +L   LT   I   + AA  HD +H G    F + T+  L  LY++  VLENHH  +   ++++    L  ++  ++  +    +  ++L TD+S       Q KS   K  L LEE   +   L   L CADI +P + WD   RW+ ++ EEFF+QGD E +  +  SPLCDR +  +P  Q+GF  F+VEP F
Sbjct:    8 WSFDMFLFDRLTNGNSLVSLTCHLFNFHGLIQHFQLDMVKLRGFLVMVQEDYHNQ-NPYHNAVHAADVTQAMHCYLREPKLAVHLTRRDIMLGLLAASAHDVDHPGVNQPFLIKTHHHLASLYHNSSVLENHHWRSTVGMLRES--GLFAHLPMDERLQMERDLGSLILATDISRQNEFLSQFKSHLDKGDLCLEEAPHRHFILQIALKCADICNPCRVWDTSKRWSEKVCEEFFKQGDMERKWRLEISPLCDRYTQTVPNIQIGFMTFVVEPLF 279

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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007435.1 (pep scaffold:Pmarinus_7.0:GL486982:1709:8825:-1 gene:ENSPMAG00000006710.1 transcript:ENSPMAT00000007435.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 150.599 bits (379), Expect = 1.155e-42
Identity = 68/170 (40.00%), Postives = 111/170 (65.29%), Query Frame = 2

Query:  917 HDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSM-----------LALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQ 1393
            HD +H G +N F +NTNS+L ++YND+ VLENHH++  F+L+Q+ + ++ +N+ K+  +  R +VI+MVL TDMS H   +  +K+M           L L+   D+   L  ++HCAD+S+P K  D++ +WT +++EEFFRQGD+E +  +  SP+CD+ S  + +SQ
Sbjct:   23 HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQNLSKKQRQTLRKMVIDMVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLQNMVHCADLSNPTKPLDVYRQWTERIMEEFFRQGDRERERGMEISPMCDKHSASVEKSQ 192

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BLAST of Phosphodiesterase vs. Ensembl Yeast
Match: PDE2 (High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon [Source:SGD;Acc:S000005887])

HSP 1 Score: 52.373 bits (124), Expect = 1.239e-7
Identity = 65/260 (25.00%), Postives = 103/260 (39.62%), Query Frame = 2

Query:  758 ALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWT---------TQLLEEFFRQ--------GDQESQLEIPFSPLCDRKSIM---------------IPESQVGFSNFIVEPSFNILG 1441
             LE  Y +  N +HN  H  DV Q   + + TY L +    +Q      AA+ HD  H GT N    N  S++   + +  +LEN H    F+ +   H   + ++ K+ +      + E +L TDM+ H       +  L  E  + + + +S I+  ADIS+  +   +  RW            LLE F +         GD    ++ P   L   ++I+               IP  Q+ F N   E  FN L 
Sbjct:  253 TLESSYHQV-NKFHNFRHAIDVMQAT-WRLCTYLLKD--NPVQTLLLCMAAIGHDVGHPGTNNQLLCNCESEVAQNFKNVSILENFH-RELFQQLLSEHWPQLLSISKKKF----DFISEAILATDMALH----SQYEDRLMHENPMKQITLISLIIKAADISNVTRTLSISARWAYLITLEFNDCALLETFHKAHRPEQDCFGDSYKNVDSPKEDLESIQNILVNVTDPDDIIKDHPHIPNGQIFFINTFAEVFFNALS 499

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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO37301 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGA1])

HSP 1 Score: 315.079 bits (806), Expect = 4.495e-103
Identity = 151/367 (41.14%), Postives = 230/367 (62.67%), Query Frame = 2

Query:  362 DAVPGEIREWLTSTFST---SASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLE 1453
            D+V  E+REW+ +TF+    +A R S + +  FR V +A++A + V K              + K + E   + +P ++ K       EW+FD+F L +   GH LR+IG ++  R + +  +KI+    D F Q +E GY ++ NPYHN  H ADV  TVH+ +    ++ +L+D+++F  + +A+IHD EHTGTTN FH+N+ SDL +LYND+ VLENHHVS  FR++Q    N++  ++ E Y + RS++I+ VL TDMS+HF+Q++ MK  L     I+    +  +LH ADIS+P KDW +H +WTT+++EEFF QGD E +L +  SPLCDR + +IPESQ+GF +FIV P+  +   +LE
Sbjct:   11 DSVNEEVREWIATTFARGPGAARRKSMVRRHTFRGVVHAVKASLYVNK--------------MLKNATERYKMHVPENVQKAF-----EWTFDVFALSESCEGHPLRYIGYEVLHRRDMLRNFKIHAMTLDRFLQDVETGYKRHSNPYHNDCHAADVTHTVHYFLECMGVSKYLSDLEVFGLLLSAIIHDLEHTGTTNAFHINSRSDLALLYNDRSVLENHHVSCAFRILQDDEKNILSGLNLEQYADVRSLMIDTVLATDMSSHFEQLRLMKVALVAGSPIENREVVQLLLHVADISNPTKDWTIHRQWTTKIMEEFFTQGDMEIELGLDVSPLCDRSTTLIPESQIGFIDFIVSPALEVCSEVLE 358

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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO46133 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQM4])

HSP 1 Score: 203.756 bits (517), Expect = 1.235e-58
Identity = 103/296 (34.80%), Postives = 176/296 (59.46%), Query Frame = 2

Query:  608 DINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSM-------------LALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLE-IPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLE 1453
            ++N+W FD F L + + GH +  +   +    + +  +KI    F N+   +E+ Y K   P+HN +H ADV QT H ++     +N  TD++I +AI A+ +HD +H G  N+F V TNS++ ++YND+ VLENHH++  F+L+Q    ++ +N+ K++ +  R ++IEMVL TD + H   + S+K+M             L LE   D+   L +++HCAD+S+P K   ++ +W  +L+EEFFRQGD+E  ++ +  SP+ DR +  I +SQV F +F+ +P +   G +++
Sbjct:  208 NVNKWDFDAFALGEATNGHPMLAVSYTILQARDLLKIFKIKPTTFINYMTLVENHYLK-DVPFHNCIHAADVTQTAHVLLSAQAFDNVFTDLEILSAIIASAVHDVDHPGVNNHFLVATNSEMALMYNDESVLENHHLAVAFQLLQHEDCDIFENLSKQERQTARRMIIEMVLATDNAKHMSLLASLKTMVETKKVAGTGSGVLCLENYTDRMQVLKSLVHCADLSNPTKPLPIYRKWVDRLMEEFFRQGDKERDIDGMEISPMMDRHNASIEKSQVVFIDFVAQPLWETWGELVQ 502

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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO32142 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVX8])

HSP 1 Score: 164.466 bits (415), Expect = 5.054e-43
Identity = 99/301 (32.89%), Postives = 158/301 (52.49%), Query Frame = 2

Query:  572 KIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLM-QQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSM-------KSMLALEENIDKGSALST----------ILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFS-PLCDRKSIMIPESQVGFSNFIV 1417
            +IP ++S  +  D  +W FDI KL+  S    L F+GL +  R+    K  I+  Y  N+ Q +E  Y +  N YHN  H ADV       +   ++   L  +   A++ AA++HD +H G TN+F  N  S+L ILYND  VLE+HH +  F+L  +    N+  N+D E++R  R  +I+MV+ T+M+ HF+ +          +S    + N    +AL+T          ++ CADI++PA+   L   W  ++ EE+F Q D+E +  +P   P+ DR +  +P SQV F ++ V
Sbjct:  508 EIPAEVSNAM-VDEADWDFDILKLEKASNHRPLYFLGLKILNRFRVCEKLNISEDYVKNWLQLIEANYHR-KNAYHNSTHAADVLHATAVFLAKERVKAVLEPLDEVASLIAAIVHDVDHPGYTNSFLCNAGSELAILYNDIAVLESHHAALAFKLTARDDKSNIFSNLDVEEFRTVRQAIIDMVMATEMTRHFEHLSKFVNSINKRRSSSTPDSNTSTSTALNTPENRTLIKRMLIKCADIANPARPRYLCKEWAYRIAEEYFSQTDEEKRRGLPVVMPVFDRATCNVPRSQVWFIDYFV 806

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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO32179 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVS5])

HSP 1 Score: 140.969 bits (354), Expect = 3.504e-36
Identity = 77/264 (29.17%), Postives = 139/264 (52.65%), Query Frame = 2

Query:  689 LFLRYNFIHKYKINLQYFDNFFQALEDGYSKYG-NPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTH------FKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFI 1459
            +++    + ++KI      +F   L + Y  Y   P+HN  H   V Q ++ +I+  ++ N +T   +   + +AL HD +H G  N + +N  ++L + YND   LENHH +  F +M+Q   N+++NV  E +++ R  +I+ +L+TDM+ H      FK++  +KS    ++   K   +  ++  +D+S+ A+  D+   W   LL+EFF Q D E    +P +P  DR  +  P +Q+GF  F++ P F  LG +   +
Sbjct:  191 MYIDLGLLDEFKIERSKLQHF---LFEVYRHYNPTPFHNFRHAFCVTQMMYGLIWLTEIFNKITKQDLLIMLTSALCHDLDHPGYNNAYQINARTELALRYNDISPLENHHCAVAFDIMKQDKSNILQNVSAETFKKIREGMIKCILSTDMARHSDILNKFKEL--LKSGFKFDDEAHKSMLMQIMIKVSDVSNEARPMDVAEPWLDCLLQEFFIQSDVEKLEGLPVAPFMDRDKVTKPSAQIGFIKFVLVPLFEALGELFPIL 449

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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO43748 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXZ4])

HSP 1 Score: 122.865 bits (307), Expect = 1.158e-30
Identity = 65/182 (35.71%), Postives = 98/182 (53.85%), Query Frame = 2

Query:  917 HDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRL-MQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQM-----KSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGN 1444
            HD++H G TN F V T S   +LYND+ VLENHH +A F L M  P  N +  +   +++ FR + IE +L TD+  HF  +     K+ +  +  +   D+   L   +  +DIS P+K  D+H  WT +++EEF+ QGD E    +  SP  DR+   + + Q  F N +V P +N   N
Sbjct:  169 HDYDHPGRTNAFLVATLSHQALLYNDRSVLENHHAAAAFTLLMSDPKYNFLCELSPAEFKRFRFLAIEAILATDLKRHFDILSDFNAKTAEGGVNWDSEADRLLTLQFCIKMSDISGPSKRRDIHTLWTERIVEEFYEQGDDERARGMAVSPYMDRQQPHVAQLQDSFINHLVAPLYNSYAN 350

HSP 2 Score: 51.6026 bits (122), Expect = 4.208e-7
Identity = 30/82 (36.59%), Postives = 44/82 (53.66%), Query Frame = 2

Query:  599 LRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFM 844
            L   + +W+F IF  D    G+ L  +   +F    F   +KI  + F N+F ALE GY  +  PYHN +H +DV Q V+F+
Sbjct:   19 LMDKVTDWNFPIF--DACEHGNILVQVSYRIFQNAGFFEIFKIPERKFLNYFFALESGY--HSIPYHNSIHASDVLQGVYFL 96

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BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde1a (calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [Source:NCBI gene;Acc:101168903])

HSP 1 Score: 394.43 bits (1012), Expect = 7.429e-131
Identity = 188/381 (49.34%), Postives = 275/381 (72.18%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFS--TSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIK 1489
            +  ++VP E+R+WL  TFS  T  S+    EKP+FR++ +A++AGI VE+              ++++++ +A L  P      L+ ++++WSFD+F   D +G HAL+FI  DL  RY+ I++++I +Q    F +ALE GYSK+ NPYHNL+H ADV QT HF++    L +WL++++I A +FAA IHDFEHTGTTNNFH++T S++ ILYND+ VLENHHVSA ++LM +  MN++ N++K+D+RE RS+VIEMV++TDMS HF+Q+K+M++ L   ++IDK   LS +LH ADISHPAK W LHY WT  L+EEFFRQGD+E +L +PFSPLCDRK+ MI +SQ+GF +FIVEP+F++L +  + +IG + ++  K
Sbjct:   43 LQAESVPSEVRDWLACTFSRRTGLSKRRPEEKPRFRSIVHAVQAGIFVER--------------MYRRTSNMAGLTYPPTALNALK-EVDQWSFDVFTFHDATGEHALKFIVYDLLTRYDLINRFRIPVQALVQFVEALESGYSKHRNPYHNLIHAADVTQTAHFLMLHTGLMHWLSELEILAMVFAAAIHDFEHTGTTNNFHIHTRSEVAILYNDRSVLENHHVSAAYKLMAEEDMNILVNLNKDDWRELRSLVIEMVMSTDMSCHFQQIKTMRNSLTQTDSIDKVKVLSLMLHAADISHPAKAWPLHYHWTHSLMEEFFRQGDKEVELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLIDTTDKVIGPLIEEDRK 408

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BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: ENSORLT00000022279.2 (pep primary_assembly:ASM223467v1:20:1384867:1412384:1 gene:ENSORLG00000017798.2 transcript:ENSORLT00000022279.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 374.785 bits (961), Expect = 4.603e-125
Identity = 183/379 (48.28%), Postives = 270/379 (71.24%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRV--SRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQP-HMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKD 1480
            + TD+VP E+R+WLT TF+     V   R +K +FR++ +A++AGI VE+              +F++++ I +L    ++   L+  ++ WSFD+F L+++SG HAL+F+  +L  RYN I+ +KI +    +F  +LE GYS + NPYHNLVH ADV QT+H+++    + +WL++++IFA IFAA IHD+EHTGTTNNFH+ T SD  +LYND+ V ENHH+SA +RL+Q+    N+  N+ K+++R+ RS+V++MVL TDMS HF+Q+K MK+++   E+ DK  ALS +LH ADISHPAK W LH+RWTT LLEEFFRQGD+E++L +PFSPLCDRKS M+ +SQ+GF +FIVEP+F ++  M+E I   + ++
Sbjct:   47 IKTDSVPVEVRDWLTVTFTQQKGLVLTRREDKQRFRSIVHAVQAGIFVER--------------MFRRTSNITSLSYSQNVITALKH-VDMWSFDVFALNEVSGNHALKFVFHELLTRYNLINVFKIPVSALISFVDSLEVGYSSHKNPYHNLVHAADVTQTLHYLLIKTGILHWLSELEIFAVIFAAAIHDYEHTGTTNNFHIQTRSDTALLYNDRAVQENHHISAAYRLLQRDDEKNIFLNLSKDEWRDLRSLVVDMVLATDMSCHFQQIKGMKNLMMQREHPDKPKALSLLLHTADISHPAKQWGLHHRWTTFLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVVTEMIETITTALAQE 410

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BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: ENSORLT00000006203.2 (phosphodiesterase 1B [Source:NCBI gene;Acc:101159577])

HSP 1 Score: 362.073 bits (928), Expect = 1.525e-117
Identity = 186/426 (43.66%), Postives = 273/426 (64.08%), Query Frame = 2

Query:  353 VNTDAVPGEIREWLTSTFSTSASRVSRI--EKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLE-FIIGMMKKDGIKLEIAENISIAQNAPVKGS--IHFPWEAKIVNNRSTWQKQIDQRK 1615
            + +D VP E+ +WL STF+    +  R   EKPKFR++ +A++AGI VE+              +FK++   A    P  +   LR D++ W FD+F L+  S  HAL+ +  +L  RY    ++KI +     F   LE GY K+ NPYHN +H ADV QT+H ++    L +WLT++++  ++FAA IHDFEHTGTTNNFH++T SDL ++YND+ V E+HH+SA FRL+Q   +N+  ++ +E++ E RS+VI+MVL TDM+ H  Q+K+MKS L  +E IDK  ALS +LH ADISHP+K W LH RWT  L+EEFFRQGD+E+ L++PFSPLCDRK+ +I ESQ+GF +FIV P+F++L +M E  +I +++++    +     S       +G    H    A++V+ RSTW +  +  K
Sbjct:   68 LQSDGVPSEVTDWLASTFTQRIRQPPRRVDEKPKFRSIVHAVQAGIFVER--------------MFKRAYTAAMPDQPAAVVNCLR-DVDRWGFDVFALNSTSSDHALQALFFELITRYELNTRFKIPISCLTKFLSTLERGYCKHNNPYHNHIHAADVTQTLHCLLLRSGLVHWLTELEVLGSLFAAAIHDFEHTGTTNNFHIHTKSDLALIYNDRSVQESHHLSAAFRLLQDEQVNIFVHLTREEWMELRSLVIDMVLATDMTFHLVQVKAMKSCLQQQERIDKPKALSLLLHTADISHPSKPWALHSRWTKALMEEFFRQGDREAALDLPFSPLCDRKTTLIAESQIGFIDFIVYPTFSLLTDMAEKIVIPLVEENPGPPDPCNRHSNLWKESSRGLQWSHAHITAELVSFRSTWTRHTEDNK 478

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BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: ENSORLT00000031990.1 (cAMP-specific 3',5'-cyclic phosphodiesterase 4B [Source:NCBI gene;Acc:101156228])

HSP 1 Score: 208.764 bits (530), Expect = 1.058e-60
Identity = 111/293 (37.88%), Postives = 179/293 (61.09%), Query Frame = 2

Query:  608 DINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGN-PYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSM-----------LALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNML 1450
            D+++WSF++FK+ + S    L  I   +F     +  ++I +  F  +   LED Y  +GN  YHN +H ADV Q+ H ++ T  LN   TD++I AA+FAA IHD +H G +N F +NTNS+L ++YND+ VLENHH++  F+L+ Q + ++ +N+ K   +  R +VIEMVL TDMS H   +  +K+M           L L+   ++   L  ++HCAD+S+P K   L+ +WT +++EEFFRQGD+E +  +  S +CD+ +  + +SQVGF ++IV P +    +++
Sbjct:   94 DLDKWSFNVFKVAEYSNNRPLSCIMYAIFQERELLKTFRIPVDTFVTYVMTLEDHY--HGNVAYHNSLHAADVTQSTHVLLSTPALNAAFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLHQENCDIFQNLTKRQRQSLRKLVIEMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDHYTERIQLLKNMVHCADLSNPTKPLPLYRQWTERIMEEFFRQGDKERERGMEISAMCDKHTASVEKSQVGFIDYIVHPLWETWADLV 384

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BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: ENSORLT00000039959.1 (cAMP-specific 3',5'-cyclic phosphodiesterase 4B [Source:NCBI gene;Acc:101156228])

HSP 1 Score: 208.379 bits (529), Expect = 5.737e-59
Identity = 111/293 (37.88%), Postives = 179/293 (61.09%), Query Frame = 2

Query:  608 DINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGN-PYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSM-----------LALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNML 1450
            D+++WSF++FK+ + S    L  I   +F     +  ++I +  F  +   LED Y  +GN  YHN +H ADV Q+ H ++ T  LN   TD++I AA+FAA IHD +H G +N F +NTNS+L ++YND+ VLENHH++  F+L+ Q + ++ +N+ K   +  R +VIEMVL TDMS H   +  +K+M           L L+   ++   L  ++HCAD+S+P K   L+ +WT +++EEFFRQGD+E +  +  S +CD+ +  + +SQVGF ++IV P +    +++
Sbjct:  271 DLDKWSFNVFKVAEYSNNRPLSCIMYAIFQERELLKTFRIPVDTFVTYVMTLEDHY--HGNVAYHNSLHAADVTQSTHVLLSTPALNAAFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLHQENCDIFQNLTKRQRQSLRKLVIEMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDHYTERIQLLKNMVHCADLSNPTKPLPLYRQWTERIMEEFFRQGDKERERGMEISAMCDKHTASVEKSQVGFIDYIVHPLWETWADLV 561

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BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000009966.1 (SMESG000009966.1)

HSP 1 Score: 1008.82 bits (2607), Expect = 0.000e+0
Identity = 518/518 (100.00%), Postives = 518/518 (100.00%), Query Frame = 2

Query:  110 MPSSKADDAILGSVRGTSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXXXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQIDQRKEELNKLEAEPTEDEKK 1663
            MPSSKADDAILGSVRGTSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMDAIANEEQININEDDEINVNTDAVPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDIQIFAAIFAALIHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQIDQRKEELNKLEAEPTEDEKK
Sbjct:    1 MPSSKADDAILGSVRGTSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMDAIANEEQININEDDEINVNTDAVPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDIQIFAAIFAALIHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQIDQRKEELNKLEAEPTEDEKK 518

[Close]

BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000009966.1 (SMESG000009966.1)

HSP 1 Score: 970.689 bits (2508), Expect = 0.000e+0
Identity = 504/518 (97.30%), Postives = 504/518 (97.30%), Query Frame = 2

Query:  110 MPSSKADDAILGSVRGTSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXXXXXXXXXXXXXXXXVNTDAVPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQIDQRKEELNKLEAEPTEDEKK 1663
            MPSSKADDAILGSVRGTSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMDAIANEEQININEDDEINVNTDAVPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEK              IFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDIQIFAAIFAALIHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQIDQRKEELNKLEAEPTEDEKK
Sbjct:    1 MPSSKADDAILGSVRGTSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMDAIANEEQININEDDEINVNTDAVPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEK--------------IFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDIQIFAAIFAALIHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQIDQRKEELNKLEAEPTEDEKK 504

[Close]

BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000004031.1 (SMESG000004031.1)

HSP 1 Score: 422.165 bits (1084), Expect = 6.689e-142
Identity = 212/469 (45.20%), Postives = 322/469 (68.66%), Query Frame = 2

Query:  200 CCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMXXXXXXXXXXXXXXXXXXVNTDA---VPGEIREWLTSTFST-SASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQ 1594
            C +R+  +IKLI  + I KEDL+K++ Y + L+   A  E+     +++ +  T A   VP E+REWL++TF+  ++S   + EKPKFR+VANAIRAGI+VE+              I+++ +  A L IP ++   +++ ++ W+F++F++D+ S  H+L+++G +LF +YN + K+KI+    +NF Q LEDGY+K+ NPYH+  H ADVAQT H +I    L+ W+TD++I A +FAALIHD+EHTGTTN FHVN++SDL +LYND+GVLENHH+S+ FRL+++    + K + KE+Y+E R +VIE+VLNTDMS HF+Q+K+MK++LA+ EN++K  A S ++HCADISHP K W LH +WT  L+EEFFRQGD+E +L +  SPLCDR + ++ +SQ+GF +FIVEPSF +LG+ML+ ++ M + +   ++  E+ +  Q          PW   I  N+  W+
Sbjct:   97 CSVRLLCIIKLIQKNKISKEDLLKNINYAI-LVLESAYIEEAKRICNEDDDFPTQANGSVPDEVREWLSNTFTRRTSSTAGKDEKPKFRSVANAIRAGILVER--------------IYRRMSSSAGLPIPPNVMILMKAGLDSWNFNVFEVDEASENHSLKYLGYELFHKYNMMTKFKIDSVILENFLQKLEDGYAKFSNPYHSFTHAADVAQTCHIIISQSGLSRWMTDLEILAVLFAALIHDYEHTGTTNGFHVNSSSDLALLYNDRGVLENHHISSVFRLIREESYQIFKGLTKEEYKELRLLVIEIVLNTDMSLHFQQLKNMKTLLAVPENVEKIKAFSLLVHCADISHPTKQWHLHEKWTLLLVEEFFRQGDREKELGLSCSPLCDRNTTVVAQSQIGFIDFIVEPSFVLLGDMLDRMMQMAQNNKEPIQNDEDFTKVQR---------PWIQCINENKEAWK 541

[Close]

BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000044267.1 (SMESG000044267.1)

HSP 1 Score: 349.747 bits (896), Expect = 2.335e-114
Identity = 175/422 (41.47%), Postives = 273/422 (64.69%), Query Frame = 2

Query:  359 TDA-VPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPVKG--SIHFPWEAKIVNNRSTWQKQIDQRK 1615
            TD+ +P  ++EW++STF T   +VS   + + R++ NA+R G+  ++               F+K +   ++  P +   +L+  IN W+FDIF  ++++  H+L+ +G +L      I ++ I++   + F   LE+GYS + NPYHNL+H ADVA T   ++   +L NWL+D+++F+ + +ALIHDFEHTGT+NN+HVN NS+L ++YND+ VLENHH+SA FRLM+    N++++++  +YRE R++VIEMVL TDMS HF Q++ MK  + L E++ K + LS +LH ADISHP K W++H++WT  ++EEFFRQGD E +  +  SPLCDR S +IPESQ+GF NFIVEP F +LG+ ++  I ++  D    E   +   ++N+ V G   I  PW   + NN+  W + I Q++
Sbjct:   74 TDSELPENVQEWISSTF-TKRQKVSPPPRQRLRSLINAVRVGMYFDRA--------------FRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGD-IQKAISILCPD----ETLLSDDPSENSTVNGEKQIQTPWMDNLGNNKVKWAQLIKQKR 475

[Close]

BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000070067.1 (SMESG000070067.1)

HSP 1 Score: 348.591 bits (893), Expect = 3.882e-114
Identity = 172/429 (40.09%), Postives = 278/429 (64.80%), Query Frame = 2

Query:  368 VPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDXXXXXXXXXXXXHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNA-PVKGSIHF---PWEAKIVNNRSTWQKQIDQRKEELNKLEAE 1642
            +P  +++W+++TF++  ++  +  + + +++   ++AGI      Y  +I+ RVS+     S+      +P  +  +++  +N W FD+F  + +   H+L+ IG +L    N I ++ I+L   ++F   +E+GYS + NPYHNL+H ADVAQT   +I   +L +W+TDI++ A + AA+IHD+EHTGTTNN+HV T+SDL ++YND+ VLEN+HVS+ F L+QQ   N++ +++KE+Y++FR+IVIEMVL TDMS HF Q+++MK  + L EN+ K + LS +LH ADISHP K WDLH +WT  ++EEFF+QGD+E    +P SPLCDR + +IP+SQ+GF NFIVEP F  L +M + ++ +   D  K EI ++  + + + P    +     PW   I +N+  W + +++  EE  + + E
Sbjct:   71 LPENVQDWISNTFTSRTTQYKQ-HRTRLKSLVKLVQAGI------YFDRIYRRVSIS----SDNF----VPPSVMSYMKDKLNSWEFDMFHFNTLCRNHSLKAIGYELMHHTNMISRFLIDLTRLESFLSKMEEGYSLHNNPYHNLIHAADVAQTCFILISKSKLISWMTDIEVLAILIAAIIHDYEHTGTTNNYHVVTSSDLALIYNDRSVLENYHVSSAFTLLQQTQYNILNSLNKEEYKQFRTIVIEMVLATDMSIHFNQLQTMKDAIMLPENLQKINILSFVLHSADISHPTKSWDLHQQWTNLVVEEFFQQGDRERTEGLPCSPLCDRHTTLIPQSQIGFINFIVEPCFQTLSDMFDAVVILFPIDESKKEIVDDSILERPSNPTPSRVIISDRPWFVHIFDNKLNWTELVNKANEETKEKKPE 484

The following BLAST results are available for this feature:

BLAST of Phosphodiesterase vs. Ensembl Human
BLAST of Phosphodiesterase vs. Ensembl Celegans
BLAST of Phosphodiesterase vs. Ensembl Fly
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
BLAST of Phosphodiesterase vs. Ensembl Xenopus
BLAST of Phosphodiesterase vs. Ensembl Mouse
BLAST of Phosphodiesterase vs. UniProt/SwissProt
BLAST of Phosphodiesterase vs. TrEMBL
BLAST of Phosphodiesterase vs. Ensembl Cavefish
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
BLAST of Phosphodiesterase vs. Ensembl Yeast
BLAST of Phosphodiesterase vs. Ensembl Nematostella
BLAST of Phosphodiesterase vs. Ensembl Medaka
BLAST of Phosphodiesterase vs. Planmine SMEST

BLAST of Phosphodiesterase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PDE1C	2.407e-137	47.38	phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:...	[more]
PDE1C	2.407e-137	47.38	phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:...	[more]
PDE1C	1.164e-136	47.38	phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:...	[more]
PDE1C	1.164e-136	47.38	phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:...	[more]
PDE1C	6.493e-135	47.69	phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of Phosphodiesterase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pde-1	1.080e-125	45.91	Probable 3',5'-cyclic phosphodiesterase pde-1 [So...	[more]
pde-1	1.338e-125	43.65	Probable 3',5'-cyclic phosphodiesterase pde-1 [So...	[more]
pde-4	4.654e-60	35.74	Probable 3',5'-cyclic phosphodiesterase pde-4 [So...	[more]
pde-4	9.233e-60	35.74	Probable 3',5'-cyclic phosphodiesterase pde-4 [So...	[more]
pde-4	1.431e-59	35.74	Probable 3',5'-cyclic phosphodiesterase pde-4 [So...	[more]

BLAST of Phosphodiesterase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pde1c	7.070e-128	48.93	gene:FBgn0264815 transcript:FBtr0334137	[more]
Pde1c	3.607e-125	45.05	gene:FBgn0264815 transcript:FBtr0334135	[more]
Pde1c	2.094e-124	48.93	gene:FBgn0264815 transcript:FBtr0334136	[more]
Pde1c	2.094e-124	48.93	gene:FBgn0264815 transcript:FBtr0334140	[more]
Pde1c	3.235e-124	48.93	gene:FBgn0264815 transcript:FBtr0344148	[more]

BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pde1a	1.398e-136	45.95	phosphodiesterase 1A, calmodulin-dependent [Source...	[more]
pde1a	5.079e-136	46.87	phosphodiesterase 1A, calmodulin-dependent [Source...	[more]
CABZ01067973.1	3.802e-133	46.79	phosphodiesterase 1C, calmodulin-dependent b [Sour...	[more]
pde4ba	1.354e-59	37.67	phosphodiesterase 4B, cAMP-specific a [Source:ZFIN...	[more]
pde4bb	1.364e-59	39.58	phosphodiesterase 4B, cAMP-specific b [Source:ZFIN...	[more]

BLAST of Phosphodiesterase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
arhgef39	2.863e-136	51.71	Rho guanine nucleotide exchange factor 39 [Source:...	[more]
arhgef39	3.305e-136	51.71	Rho guanine nucleotide exchange factor 39 [Source:...	[more]
PDE1C	4.814e-135	46.05	phosphodiesterase 1C [Source:NCBI gene;Acc:1004953...	[more]
PDE1C	1.630e-134	51.74	phosphodiesterase 1C [Source:NCBI gene;Acc:1004953...	[more]
PDE1C	2.085e-134	51.74	phosphodiesterase 1C [Source:NCBI gene;Acc:1004953...	[more]

BLAST of Phosphodiesterase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pde1c	1.561e-137	47.38	phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10...	[more]
Pde1c	1.561e-137	47.38	phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10...	[more]
Pde1c	2.860e-137	47.38	phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10...	[more]
Pde1c	2.860e-137	47.38	phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10...	[more]
Pde1c	4.392e-137	47.58	phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10...	[more]

BLAST of Phosphodiesterase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q14123\|PDE1C_HUMAN	5.589e-136	47.38	Calcium/calmodulin-dependent 3',5'-cyclic nucleoti...	[more]
sp\|Q64338\|PDE1C_MOUSE	9.372e-136	47.38	Calcium/calmodulin-dependent 3',5'-cyclic nucleoti...	[more]
sp\|Q63421\|PDE1C_RAT	1.612e-134	47.69	Calcium/calmodulin-dependent 3',5'-cyclic nucleoti...	[more]
sp\|P14100\|PDE1A_BOVIN	1.445e-130	49.47	Calcium/calmodulin-dependent 3',5'-cyclic nucleoti...	[more]
sp\|P54750\|PDE1A_HUMAN	1.093e-129	48.48	Calcium/calmodulin-dependent 3',5'-cyclic nucleoti...	[more]

BLAST of Phosphodiesterase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267DMF6	2.132e-157	47.08	Phosphodiesterase OS=Macrostomum lignano OX=282301...	[more]
A0A267DMU5	4.059e-157	47.28	Phosphodiesterase OS=Macrostomum lignano OX=282301...	[more]
A0A1I8J257	7.843e-155	49.58	Phosphodiesterase OS=Macrostomum lignano OX=282301...	[more]
A0A267EML7	2.549e-151	49.16	Phosphodiesterase OS=Macrostomum lignano OX=282301...	[more]
A0A267EIK0	3.755e-151	49.16	Phosphodiesterase OS=Macrostomum lignano OX=282301...	[more]

BLAST of Phosphodiesterase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PDE1C	7.673e-134	43.80	phosphodiesterase 1C [Source:NCBI gene;Acc:1030407...	[more]
PDE1C	1.912e-132	47.02	phosphodiesterase 1C [Source:NCBI gene;Acc:1030407...	[more]
ENSAMXT00000048550.1	1.954e-132	51.47	pep primary_assembly:Astyanax_mexicanus-2.0:17:437...	[more]
PDE1C	2.109e-132	47.78	phosphodiesterase 1C [Source:NCBI gene;Acc:1030407...	[more]
ENSAMXT00000040842.1	2.317e-132	51.47	pep primary_assembly:Astyanax_mexicanus-2.0:17:437...	[more]

BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pde1a	3.491e-133	44.30	phosphodiesterase 1A, calmodulin-dependent [Source...	[more]
PDE1C	2.562e-130	44.68	phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:...	[more]
ENSPMAT00000003038.1	1.263e-67	52.08	pep scaffold:Pmarinus_7.0:GL476485:41:13228:1 gene...	[more]
pde7a	7.887e-44	33.82	phosphodiesterase 7A [Source:ZFIN;Acc:ZDB-GENE-031...	[more]
ENSPMAT00000007435.1	1.155e-42	40.00	pep scaffold:Pmarinus_7.0:GL486982:1709:8825:-1 ge...	[more]

BLAST of Phosphodiesterase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
PDE2	1.239e-7	25.00	High-affinity cyclic AMP phosphodiesterase; compon...	[more]

BLAST of Phosphodiesterase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO37301	4.495e-103	41.14	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO46133	1.235e-58	34.80	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32142	5.054e-43	32.89	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32179	3.504e-36	29.17	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43748	1.158e-30	35.71	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Phosphodiesterase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pde1a	7.429e-131	49.34	calcium/calmodulin-dependent 3',5'-cyclic nucleoti...	[more]
ENSORLT00000022279.2	4.603e-125	48.28	pep primary_assembly:ASM223467v1:20:1384867:141238...	[more]
ENSORLT00000006203.2	1.525e-117	43.66	phosphodiesterase 1B [Source:NCBI gene;Acc:1011595...	[more]
ENSORLT00000031990.1	1.058e-60	37.88	cAMP-specific 3',5'-cyclic phosphodiesterase 4B [S...	[more]
ENSORLT00000039959.1	5.737e-59	37.88	cAMP-specific 3',5'-cyclic phosphodiesterase 4B [S...	[more]

BLAST of Phosphodiesterase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000009966.1	0.000e+0	100.00	SMESG000009966.1	[more]
SMESG000009966.1	0.000e+0	97.30	SMESG000009966.1	[more]
SMESG000004031.1	6.689e-142	45.20	SMESG000004031.1	[more]
SMESG000044267.1	2.335e-114	41.47	SMESG000044267.1	[more]
SMESG000070067.1	3.882e-114	40.09	SMESG000070067.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30008218 ID=SMED30008218|Name=Phosphodiesterase|organism=Schmidtea mediterranea sexual|type=transcript|length=1727bp
TTTCATTAATTTGTGGATTTAATTAACTTTCTAATGGGTATGATTCTGAA
CATCAAAAATCGGATATGAACTGAATTAGAACAAAAAAAATACAAAATGT
ATTACTGAAATGCCATCCTCAAAAGCAGACGACGCGATTCTCGGATCGGT
ACGGGGAACTTCTAGGAAGCGAGATAAAGCTCTTTCTCAATTCATTGAAT
GTTGCATAAGAGTTCGACAAGTGATAAAGTTGATCCATTCCGACGGAATT
CGGAAGGAGGATTTGATTAAAAGTCTTGCGTATACCGTTGAGTTGATGGA
CGCGATTGCAAACGAAGAACAAATAAACATAAACGAAGATGATGAGATAA
ATGTGAATACGGACGCAGTTCCAGGAGAAATCCGTGAATGGTTGACATCA
ACGTTTTCCACAAGTGCTAGCCGAGTGTCACGGATTGAGAAACCAAAGTT
TCGTGCTGTTGCAAACGCAATCAGAGCTGGGATAATGGTGGAAAAAGGAA
ATTATTCGTACAAAATTCATTTACGAGTTTCATTAAAAATTTTCAAAAAA
TCAAACGAAATTGCCGCCTTAAAAATTCCAAATGATATTTCAAAATTCTT
AAGATCAGATATTAATGAATGGTCATTTGATATATTCAAACTCGACGATA
TGTCGGGGGGTCACGCTTTACGATTTATTGGCCTAGATCTATTTTTACGA
TACAATTTCATCCACAAATACAAGATCAATCTTCAATATTTTGACAATTT
CTTCCAAGCCTTAGAAGACGGCTACAGCAAATATGGAAACCCTTATCACA
ATCTCGTTCACGGAGCCGACGTAGCACAAACCGTTCACTTTATGATATAC
ACATATCAACTCAATAACTGGTTGACTGACATTCAAATATTTGCAGCCAT
CTTTGCAGCTTTGATCCATGACTTTGAACATACTGGGACGACAAATAATT
TCCATGTCAATACTAACTCAGATTTGACGATCCTCTACAATGACAAAGGA
GTTTTAGAAAATCATCACGTTTCAGCTTGCTTCCGTTTGATGCAACAGCC
TCACATGAATCTGATGAAGAATGTCGACAAAGAAGATTATAGGGAGTTTC
GGTCCATAGTTATTGAGATGGTACTAAACACAGACATGTCCACCCATTTC
AAGCAAATGAAAAGCATGAAGAGCATGTTAGCTCTGGAAGAAAACATTGA
TAAAGGAAGTGCTCTATCGACAATTTTGCATTGTGCCGATATCTCCCATC
CGGCCAAAGACTGGGATTTGCATTATCGTTGGACCACTCAATTACTTGAG
GAGTTTTTTCGACAGGGTGACCAAGAAAGCCAGTTGGAGATTCCCTTTTC
ACCTTTATGTGATAGAAAAAGTATCATGATACCTGAATCCCAAGTTGGTT
TTTCTAATTTTATCGTTGAGCCTAGTTTCAACATATTGGGCAATATGCTA
GAGTTCATCATAGGCATGATGAAAAAGGATGGAATTAAATTGGAAATAGC
CGAAAATATATCAATTGCTCAAAACGCTCCAGTGAAAGGCTCAATACATT
TTCCCTGGGAAGCAAAAATAGTCAACAACCGTTCAACATGGCAGAAACAG
ATTGATCAGAGGAAAGAGGAACTTAATAAATTAGAAGCTGAACCTACCGA
AGATGAGAAGAAATAATATTTTTGTTATGATTTTCATATAAATTATCTAT
GTTTTCAAAAGAAATAATGAATACATG

protein sequence of SMED30008218-orf-1

>SMED30008218-orf-1 ID=SMED30008218-orf-1|Name=SMED30008218-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=519bp
MPSSKADDAILGSVRGTSRKRDKALSQFIECCIRVRQVIKLIHSDGIRKE
DLIKSLAYTVELMDAIANEEQININEDDEINVNTDAVPGEIREWLTSTFS
TSASRVSRIEKPKFRAVANAIRAGIMVEKGNYSYKIHLRVSLKIFKKSNE
IAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNF
IHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQ
LNNWLTDIQIFAAIFAALIHDFEHTGTTNNFHVNTNSDLTILYNDKGVLE
NHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQM
KSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFF
RQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFI
IGMMKKDGIKLEIAENISIAQNAPVKGSIHFPWEAKIVNNRSTWQKQIDQ
RKEELNKLEAEPTEDEKK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0002089	reproductive organ

Vocabulary: **INTERPRO**
Term	Definition
IPR036971	PDEase_catalytic_dom_sf
IPR003607	HD/PDEase_dom
IPR013706	PDEase_N
IPR002073	PDEase_catalytic_dom
IPR023174	PDEase_CS
IPR023088	PDEase

Vocabulary: **molecular function**
Term	Definition
GO:0008081	phosphoric diester hydrolase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Vocabulary: **biological process**
Term	Definition
GO:0007165	signal transduction

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 491..511
None	No IPR available	PANTHER	PTHR11347:SF199	CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1	coord: 33..516
None	No IPR available	PANTHER	PTHR11347	CYCLIC NUCLEOTIDE PHOSPHODIESTERASE	coord: 33..516
None	No IPR available	SUPERFAMILY	SSF109604	HD-domain/PDEase-like	coord: 162..506
IPR023088	3'5'-cyclic nucleotide phosphodiesterase	PRINTS	PR00387	PDIESTERASE1	coord: 297..313 score: 45.41 coord: 270..285 score: 50.88 coord: 225..238 score: 50.86 coord: 256..269 score: 48.86 coord: 373..386 score: 46.0 coord: 390..406 score: 53.41
IPR003607	HD/PDEase domain	SMART	SM00471	hd_13	coord: 227..391 e-value: 2.0E-7 score: 40.7
IPR003607	HD/PDEase domain	CDD	cd00077	HDc	coord: 229..400 e-value: 7.6216E-12 score: 61.2013
IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily	GENE3D	G3DSA:1.10.1300.10		coord: 148..505 e-value: 2.2E-128 score: 430.4
IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	PFAM	PF00233	PDEase_I	coord: 229..452 e-value: 2.6E-78 score: 263.0
IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	PROSITE	PS51845	PDEASE_I_2	coord: 152..501 score: 112.232
IPR013706	3'5'-cyclic nucleotide phosphodiesterase N-terminal	PFAM	PF08499	PDEase_I_N	coord: 75..129 e-value: 7.1E-18 score: 64.2
IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site	PROSITE	PS00126	PDEASE_I_1	coord: 270..281