HATPase_c domain-containing protein

Overview


Name	HATPase_c domain-containing protein
Smed ID	SMED30008204
Length (bp)	529

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of HATPase_c domain-containing protein (SMED30008204) t-SNE clustered cells

Violin plots show distribution of expression levels for HATPase_c domain-containing protein (SMED30008204) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of HATPase_c domain-containing protein (SMED30008204) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for HATPase_c domain-containing protein (SMED30008204) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30008204

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 31

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Lifecycle
head region	SMED30008204	h1SMcG0006787	SmedASXL_061618	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
Smed sexual biotype	SMED30008204	h1SMcG0006787	Contig31297	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006787	Contig31297	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006787	Contig32555	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006787	Contig32555	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30008204	h1SMcG0006787	dd_Smed_v4_1693_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30008204	h1SMcG0006787	dd_Smed_v4_1693_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30008204	h1SMcG0006787	dd_Smed_v4_1693_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006787	Contig563	GPL15192	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30008204	h1SMcG0006787	dd_Smed_v4_3684_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30008204	h1SMcG0006787	dd_Smed_v4_3684_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30008204	h1SMcG0006787	dd_Smed_v4_2265_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30008204	h1SMcG0006787	dd_Smed_v4_2265_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30008204	h1SMcG0006787	dd_Smed_v4_2265_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30008204	h1SMcG0006787	dd_Smed_v4_2265_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30008204	h1SMcG0006787	dd_Smed_v4_2265_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0019490	Contig563	GPL15192	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006787	Contig38791	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006787	Contig38791	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006787	Contig39149	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006787	Contig39149	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006788	Contig39149	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008204	h1SMcG0006788	Contig39149	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
head region	SMED30008204	h1SMcG0006787	dd_Smed_v6_1693_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
pharynx musculature	SMED30008204	h1SMcG0006787	dd_Smed_v6_2265_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
musculature system	SMED30008204	h1SMcG0006787	dd_Smed_v6_2265_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
pharynx musculature	SMED30008204	h1SMcG0006787	dd_Smed_v6_1693_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
musculature system	SMED30008204	h1SMcG0006787	dd_Smed_v6_1693_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
reproductive organ	SMED30008204	h1SMcG0006787	Contig15693	newmark_ests	PMID:28434803 Rouhana et al., 2017
reproductive organ	SMED30008204	h1SMcG0006787	Contig15693	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
testis primordium	SMED30008204	h1SMcG0006787	Contig5941_SE3	GPL10652	PMID:20844018 Wang et al., 2010	juvenile stage

Note: Hover over icons to view figure legend

Homology

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BLAST of HATPase_c domain-containing protein vs. Ensembl Human
Match: HSP90B1 (heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028])

HSP 1 Score: 129.798 bits (325), Expect = 1.179e-34
Identity = 59/129 (45.74%), Postives = 83/129 (64.34%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK  EIN +H LIR +       +D      LA  L++TA LRSGY++ +  ++  ++  +++ S+ I
Sbjct:  621 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNI 749

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BLAST of HATPase_c domain-containing protein vs. Ensembl Human
Match: HSP90B1 (heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028])

HSP 1 Score: 92.0485 bits (227), Expect = 1.365e-23
Identity = 41/98 (41.84%), Postives = 61/98 (62.24%), Query Frame = 1

Query:   94 YGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            YGWSGNMERIMKAQAYQ  +++   Y  +QKK  EIN +H LIR +       +D      LA  L++TA LRSGY++ +  ++  ++  +++ S+ I
Sbjct:    3 YGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNI 100

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BLAST of HATPase_c domain-containing protein vs. Ensembl Human
Match: HSP90AA1 (heat shock protein 90 alpha family class A member 1 [Source:HGNC Symbol;Acc:HGNC:5253])

HSP 1 Score: 93.9745 bits (232), Expect = 4.354e-22
Identity = 48/123 (39.02%), Postives = 75/123 (60.98%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L+  +EKV +S RL TSPC ++ STYGW+ NMERIMKAQA + +  +     +  KK LEIN  HS+I  L+      ++    + L   LY+TALL SG+ +++  + + +++ +IK  + I
Sbjct:  701 LEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGI 820

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BLAST of HATPase_c domain-containing protein vs. Ensembl Human
Match: HSP90AA1 (heat shock protein 90 alpha family class A member 1 [Source:HGNC Symbol;Acc:HGNC:5253])

HSP 1 Score: 93.2041 bits (230), Expect = 5.946e-22
Identity = 48/123 (39.02%), Postives = 75/123 (60.98%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L+  +EKV +S RL TSPC ++ STYGW+ NMERIMKAQA + +  +     +  KK LEIN  HS+I  L+      ++    + L   LY+TALL SG+ +++  + + +++ +IK  + I
Sbjct:  579 LEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGI 698

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BLAST of HATPase_c domain-containing protein vs. Ensembl Human
Match: HSP90AB1 (heat shock protein 90 alpha family class B member 1 [Source:HGNC Symbol;Acc:HGNC:5258])

HSP 1 Score: 90.5077 bits (223), Expect = 6.730e-21
Identity = 46/119 (38.66%), Postives = 73/119 (61.34%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV IS RL +SPC ++ STYGW+ NMERIMKAQA + +  +   Y +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +++  + S +++ +IK  + I
Sbjct:  575 VEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTM--GYMM-AKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGI 690

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BLAST of HATPase_c domain-containing protein vs. Ensembl Celegans
Match: enpl-1 (Endoplasmin homolog [Source:UniProtKB/Swiss-Prot;Acc:Q22235])

HSP 1 Score: 122.094 bits (305), Expect = 2.254e-32
Identity = 55/129 (42.64%), Postives = 83/129 (64.34%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            WLK T LKD IEK  +S+RL  SP  L+AS+YGWSGNMERIMK+QAY K+++  Q +   QKK  EIN +H +I+ L    +  ++       AK L++TA LRSG+ + +   F+ ++  +++ S+ +
Sbjct:  526 WLKETALKDLIEKAVVSQRLVKSPSALVASSYGWSGNMERIMKSQAYAKAKDPTQDFYATQKKTFEINPRHPVIKELLKRVTASEEDTTAASTAKLLFETATLRSGFSLQDQVGFADRIEAVLRQSLDV 654

[Close]

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            WLK T LKD IEK  +S+RL  SP  L+AS+YGWSGNMERIMK+QAY K+++  Q +   QKK  EIN +H +I+ L    +  ++       AK L++TA LRSG+ + +   F+ ++  +++ S+ +
Sbjct:  526 WLKETALKDLIEKAVVSQRLVKSPSALVASSYGWSGNMERIMKSQAYAKAKDPTQDFYATQKKTFEINPRHPVIKELLKRVTASEEDTTAASTAKLLFETATLRSGFSLQDQVGFADRIEAVLRQSLDV 654

[Close]

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            WLK T LKD IEK  +S+RL  SP  L+AS+YGWSGNMERIMK+QAY K+++  Q +   QKK  EIN +H +I+ L    +  ++       AK L++TA LRSG+ + +   F+ ++  +++ S+ +
Sbjct:  526 WLKETALKDLIEKAVVSQRLVKSPSALVASSYGWSGNMERIMKSQAYAKAKDPTQDFYATQKKTFEINPRHPVIKELLKRVTASEEDTTAASTAKLLFETATLRSGFSLQDQVGFADRIEAVLRQSLDV 654

[Close]

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            WLK T LKD IEK  +S+RL  SP  L+AS+YGWSGNMERIMK+QAY K+++  Q +   QKK  EIN +H +I+ L    +  ++       AK L++TA LRSG+ + +   F+ ++  +++ S+ +
Sbjct:  526 WLKETALKDLIEKAVVSQRLVKSPSALVASSYGWSGNMERIMKSQAYAKAKDPTQDFYATQKKTFEINPRHPVIKELLKRVTASEEDTTAASTAKLLFETATLRSGFSLQDQVGFADRIEAVLRQSLDV 654

[Close]

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            WLK T LKD IEK  +S+RL  SP  L+AS+YGWSGNMERIMK+QAY K+++  Q +   QKK  EIN +H +I+ L    +  ++       AK L++TA LRSG+ + +   F+ ++  +++ S+ +
Sbjct:  526 WLKETALKDLIEKAVVSQRLVKSPSALVASSYGWSGNMERIMKSQAYAKAKDPTQDFYATQKKTFEINPRHPVIKELLKRVTASEEDTTAASTAKLLFETATLRSGFSLQDQVGFADRIEAVLRQSLDV 654

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BLAST of HATPase_c domain-containing protein vs. Ensembl Fly
Match: Gp93 (gene:FBgn0039562 transcript:FBtr0085254)

HSP 1 Score: 119.013 bits (297), Expect = 3.193e-31
Identity = 50/129 (38.76%), Postives = 83/129 (64.34%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            WL    LKD I K ++SERL+ SPC L+A  +GW+GNMER+  + A+QKS++  +TY +NQKK LEIN +H L+R L       +  +  + +A  ++ TA LRSGY++   + F+  + ++++ ++ +
Sbjct:  618 WLNDVALKDQISKAQVSERLSNSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEADDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGV 746

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BLAST of HATPase_c domain-containing protein vs. Ensembl Fly
Match: Hsp83 (gene:FBgn0001233 transcript:FBtr0332873)

HSP 1 Score: 86.2705 bits (212), Expect = 9.278e-20
Identity = 43/123 (34.96%), Postives = 71/123 (57.72%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L + +EKV +S RL  SPC ++ S +GWS NMERIMKAQA + +      Y   +K+ LEIN  H ++  L+      ++    + L   L++T+LL SG+ +D+    + +++ +IK  + I
Sbjct:  564 LDNKVEKVVVSNRLVDSPCCIVTSQFGWSANMERIMKAQALRDT--ATMGYMAGKKQ-LEINPDHPIVETLRQKADADKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGI 683

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Fly
Match: Hsp83 (gene:FBgn0001233 transcript:FBtr0073040)

HSP 1 Score: 86.2705 bits (212), Expect = 9.278e-20
Identity = 43/123 (34.96%), Postives = 71/123 (57.72%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L + +EKV +S RL  SPC ++ S +GWS NMERIMKAQA + +      Y   +K+ LEIN  H ++  L+      ++    + L   L++T+LL SG+ +D+    + +++ +IK  + I
Sbjct:  564 LDNKVEKVVVSNRLVDSPCCIVTSQFGWSANMERIMKAQALRDT--ATMGYMAGKKQ-LEINPDHPIVETLRQKADADKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGI 683

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Zebrafish
Match: hsp90b1 (heat shock protein 90, beta (grp94), member 1 [Source:ZFIN;Acc:ZDB-GENE-031002-1])

HSP 1 Score: 125.946 bits (315), Expect = 1.862e-33
Identity = 58/131 (44.27%), Postives = 85/131 (64.89%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LK+ IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK LEIN +H LI+ +    +   +      LA  L++TA LRSGY + +  ++ +++  +++ SM + L
Sbjct:  621 WMKDKALKEQIEKAVLSQRLTNSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTLEINPKHPLIKEMLRRVNEDAEDKTAADLAVVLFETATLRSGYQLQDTKAYGERIERMLRLSMNVDL 751

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Zebrafish
Match: hsp90b1 (heat shock protein 90, beta (grp94), member 1 [Source:ZFIN;Acc:ZDB-GENE-031002-1])

HSP 1 Score: 125.561 bits (314), Expect = 2.120e-33
Identity = 58/131 (44.27%), Postives = 85/131 (64.89%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LK+ IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK LEIN +H LI+ +    +   +      LA  L++TA LRSGY + +  ++ +++  +++ SM + L
Sbjct:  622 WMKDKALKEQIEKAVLSQRLTNSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTLEINPKHPLIKEMLRRVNEDAEDKTAADLAVVLFETATLRSGYQLQDTKAYGERIERMLRLSMNVDL 752

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Zebrafish
Match: hsp90aa1.2 (heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-031001-3])

HSP 1 Score: 92.4337 bits (228), Expect = 7.722e-22
Identity = 45/119 (37.82%), Postives = 72/119 (60.50%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +     +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +D+  + S +++ +IK  + I
Sbjct:  585 VEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHPIVETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLDDPQTHSNRIYRMIKLGLGI 700

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Zebrafish
Match: hsp90ab1 (heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-031001-3])

HSP 1 Score: 91.2781 bits (225), Expect = 2.224e-21
Identity = 46/119 (38.66%), Postives = 73/119 (61.34%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +   Y +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +D+  + S +++ +IK  + I
Sbjct:  574 VEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTM--GYMM-AKKHLEINPDHPIMETLRQKAEADKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGI 689

[Close]

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +   Y +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +D+  + S +++ +IK  + I
Sbjct:  574 VEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTM--GYMM-AKKHLEINPDHPIMETLRQKAEADKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGI 689

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Xenopus
Match: hsp90b1 (heat shock protein 90kDa beta (Grp94), member 1 [Source:NCBI gene;Acc:734089])

HSP 1 Score: 129.798 bits (325), Expect = 1.100e-34
Identity = 61/131 (46.56%), Postives = 83/131 (63.36%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y   QKK  EIN +H LI+ +       +D      LA  L++TA LRSGY + +  S+  ++  +++ S+KI L
Sbjct:  620 WMKEKALKDQIEKAVVSQRLTQSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYSGQKKTFEINPRHPLIKEMLQRVKENEDDKTVADLAVVLFETATLRSGYHLPDTKSYGDRIERMLRLSLKIDL 750

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Xenopus
Match: hsp90b1 (heat shock protein 90kDa beta (Grp94), member 1 [Source:NCBI gene;Acc:734089])

HSP 1 Score: 129.413 bits (324), Expect = 1.418e-34
Identity = 61/131 (46.56%), Postives = 83/131 (63.36%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y   QKK  EIN +H LI+ +       +D      LA  L++TA LRSGY + +  S+  ++  +++ S+KI L
Sbjct:  593 WMKEKALKDQIEKAVVSQRLTQSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYSGQKKTFEINPRHPLIKEMLQRVKENEDDKTVADLAVVLFETATLRSGYHLPDTKSYGDRIERMLRLSLKIDL 723

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Xenopus
Match: hsp90b1 (heat shock protein 90kDa beta (Grp94), member 1 [Source:NCBI gene;Acc:734089])

HSP 1 Score: 129.413 bits (324), Expect = 1.510e-34
Identity = 61/131 (46.56%), Postives = 83/131 (63.36%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y   QKK  EIN +H LI+ +       +D      LA  L++TA LRSGY + +  S+  ++  +++ S+KI L
Sbjct:  613 WMKEKALKDQIEKAVVSQRLTQSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYSGQKKTFEINPRHPLIKEMLQRVKENEDDKTVADLAVVLFETATLRSGYHLPDTKSYGDRIERMLRLSLKIDL 743

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Xenopus
Match: hsp90b1 (heat shock protein 90kDa beta (Grp94), member 1 [Source:NCBI gene;Acc:734089])

HSP 1 Score: 129.413 bits (324), Expect = 1.575e-34
Identity = 61/131 (46.56%), Postives = 83/131 (63.36%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y   QKK  EIN +H LI+ +       +D      LA  L++TA LRSGY + +  S+  ++  +++ S+KI L
Sbjct:  591 WMKEKALKDQIEKAVVSQRLTQSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYSGQKKTFEINPRHPLIKEMLQRVKENEDDKTVADLAVVLFETATLRSGYHLPDTKSYGDRIERMLRLSLKIDL 721

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Xenopus
Match: hsp90b1 (heat shock protein 90kDa beta (Grp94), member 1 [Source:NCBI gene;Acc:734089])

HSP 1 Score: 125.176 bits (313), Expect = 4.227e-33
Identity = 61/131 (46.56%), Postives = 83/131 (63.36%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y   QKK  EIN +H LI+ +       +D      LA  L++TA LRSGY + +  S+  ++  +++ S+KI L
Sbjct:  611 WMKEKALKDQIEKAVVSQRLTQSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYSGQKKTFEINPRHPLIKEMLQ--RENEDDKTVADLAVVLFETATLRSGYHLPDTKSYGDRIERMLRLSLKIDL 739

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Mouse
Match: Hsp90b1 (heat shock protein 90, beta (Grp94), member 1 [Source:MGI Symbol;Acc:MGI:98817])

HSP 1 Score: 130.183 bits (326), Expect = 6.535e-35
Identity = 59/129 (45.74%), Postives = 83/129 (64.34%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK  EIN +H LIR +       +D      LA  L++TA LRSGY++ +  ++  ++  +++ S+ I
Sbjct:  621 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNI 749

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Mouse
Match: Hsp90b1 (heat shock protein 90, beta (Grp94), member 1 [Source:MGI Symbol;Acc:MGI:98817])

HSP 1 Score: 104.76 bits (260), Expect = 1.060e-26
Identity = 46/77 (59.74%), Postives = 56/77 (72.73%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHL 231
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK  EIN +H LIR +
Sbjct:  297 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDM 373

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Mouse
Match: Hsp90aa1 (heat shock protein 90, alpha (cytosolic), class A member 1 [Source:MGI Symbol;Acc:MGI:96250])

HSP 1 Score: 93.5893 bits (231), Expect = 3.967e-22
Identity = 48/123 (39.02%), Postives = 75/123 (60.98%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L+  +EKV +S RL TSPC ++ STYGW+ NMERIMKAQA + +  +     +  KK LEIN  HS+I  L+      ++    + L   LY+TALL SG+ +++  + + +++ +IK  + I
Sbjct:  580 LEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGI 699

[Close]

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L+  +EKV +S RL TSPC ++ STYGW+ NMERIMKAQA + +  +     +  KK LEIN  HS+I  L+      ++    + L   LY+TALL SG+ +++  + + +++ +IK  + I
Sbjct:  580 LEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGI 699

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Mouse
Match: Hsp90ab1 (heat shock protein 90 alpha (cytosolic), class B member 1 [Source:MGI Symbol;Acc:MGI:96247])

HSP 1 Score: 90.5077 bits (223), Expect = 4.446e-21
Identity = 46/119 (38.66%), Postives = 73/119 (61.34%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV IS RL +SPC ++ STYGW+ NMERIMKAQA + +  +   Y +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +++  + S +++ +IK  + I
Sbjct:  575 VEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTM--GYMM-AKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGI 690

[Close]

BLAST of HATPase_c domain-containing protein vs. UniProt/SwissProt
Match: sp|P08712|ENPL_MESAU (Endoplasmin (Fragment) OS=Mesocricetus auratus OX=10036 GN=HSP90B1 PE=1 SV=1)

HSP 1 Score: 130.183 bits (326), Expect = 2.876e-35
Identity = 59/129 (45.74%), Postives = 84/129 (65.12%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK  EIN +H LIR +       +D      LA  L++TA LRSGY++ +  +++ ++  +++ S+ I
Sbjct:  218 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYADRIERMLRLSLNI 346

[Close]

BLAST of HATPase_c domain-containing protein vs. UniProt/SwissProt
Match: sp|Q95M18|ENPL_BOVIN (Endoplasmin OS=Bos taurus OX=9913 GN=HSP90B1 PE=2 SV=1)

HSP 1 Score: 130.183 bits (326), Expect = 4.446e-34
Identity = 59/129 (45.74%), Postives = 83/129 (64.34%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK  EIN +H LIR +       +D      LA  L++TA LRSGY++ +  ++  ++  +++ S+ I
Sbjct:  621 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKEDEDDKTVSDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNI 749

[Close]

BLAST of HATPase_c domain-containing protein vs. UniProt/SwissProt
Match: sp|P08113|ENPL_MOUSE (Endoplasmin OS=Mus musculus OX=10090 GN=Hsp90b1 PE=1 SV=2)

HSP 1 Score: 130.183 bits (326), Expect = 4.571e-34
Identity = 59/129 (45.74%), Postives = 83/129 (64.34%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK  EIN +H LIR +       +D      LA  L++TA LRSGY++ +  ++  ++  +++ S+ I
Sbjct:  621 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNI 749

[Close]

BLAST of HATPase_c domain-containing protein vs. UniProt/SwissProt
Match: sp|Q29092|ENPL_PIG (Endoplasmin OS=Sus scrofa OX=9823 GN=HSP90B1 PE=2 SV=3)

HSP 1 Score: 129.798 bits (325), Expect = 5.294e-34
Identity = 59/129 (45.74%), Postives = 83/129 (64.34%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK  EIN +H LIR +       +D      LA  L++TA LRSGY++ +  ++  ++  +++ S+ I
Sbjct:  621 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKEDEDDKTVSDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNI 749

[Close]

BLAST of HATPase_c domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5R6F7|ENPL_PONAB (Endoplasmin OS=Pongo abelii OX=9601 GN=HSP90B1 PE=2 SV=1)

HSP 1 Score: 129.798 bits (325), Expect = 5.611e-34
Identity = 59/129 (45.74%), Postives = 83/129 (64.34%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK  EIN +H LIR +       +D      LA  L++TA LRSGY++ +  ++  ++  +++ S+ I
Sbjct:  621 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNI 749

[Close]

BLAST of HATPase_c domain-containing protein vs. TrEMBL
Match: A0A2R4NBU5 (Heat shock protein 902 OS=Dugesia japonica OX=6161 GN=hsp902 PE=2 SV=1)

HSP 1 Score: 230.335 bits (586), Expect = 6.122e-68
Identity = 128/176 (72.73%), Postives = 147/176 (83.52%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPLXXXXXXXXXXXXXTPRQTGTEKLNNENIAPKFDEENKSDKSSAKD 528
            WLK+  LKDY+EKVEISERLT+SPCVLIA+TYGWSGNMERIMKAQAYQKS+EVMQ YQVNQKKILEIN +H LIR LKYS +  Q++NETR LAK LYDTALLRSGYI++NVASFSKQV  II+TSMKIP D++IIDDEEI+EDT ++  TEK  +EN         K+DK SAKD
Sbjct:  633 WLKTDVLKDYVEKVEISERLTSSPCVLIATTYGWSGNMERIMKAQAYQKSDEVMQNYQVNQKKILEINPRHPLIRQLKYSLNKNQNINETRALAKLLYDTALLRSGYILNNVASFSKQVDTIIRTSMKIPHDENIIDDEEIMEDTFKEPVTEKSEDEN--------KKNDKFSAKD 800

[Close]

BLAST of HATPase_c domain-containing protein vs. TrEMBL
Match: R7U2A8 (HATPase_c domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_159587 PE=3 SV=1)

HSP 1 Score: 152.14 bits (383), Expect = 1.934e-39
Identity = 67/131 (51.15%), Postives = 94/131 (71.76%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LKD IEK  ISERLT SPC L+AS+YGWSGNMERIMKAQAYQK+++   T+  NQKK LE+N +H L++ LK      +D   T+ LA+ L++TA LRSGY + + A+F+ ++  +++ S+ +PL
Sbjct:  618 WMKEDALKDKIEKAVISERLTESPCALVASSYGWSGNMERIMKAQAYQKADDTSSTFYANQKKTLEVNVRHPLVKELKERMETDKDDQTTKDLAEVLFETATLRSGYTLQDTAAFAGRIERMLRLSVDVPL 748

[Close]

BLAST of HATPase_c domain-containing protein vs. TrEMBL
Match: A0A2T7NSL7 (HATPase_c domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_14649 PE=3 SV=1)

HSP 1 Score: 144.821 bits (364), Expect = 8.781e-37
Identity = 65/131 (49.62%), Postives = 92/131 (70.23%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            WLK + LK+ IEK  ISERL+TSPC L+AS YGWSGNMERIM+AQAY K ++  Q +  NQKK LE+N +H LI+ LK      +D    + LA  +++TA LRSGY++ + A F+++V  +++ S+ +PL
Sbjct:  613 WLKDSALKEKIEKATISERLSTSPCALVASQYGWSGNMERIMRAQAYAKQQDPSQQFYSNQKKTLEVNPRHPLIKELKARVEVNKDDETAKDLAVVMFETATLRSGYLLPDTAGFAERVERMLRLSLDVPL 743

[Close]

BLAST of HATPase_c domain-containing protein vs. TrEMBL
Match: A0A0N4UU82 (Uncharacterized protein OS=Enterobius vermicularis OX=51028 GN=EVEC_LOCUS647 PE=4 SV=1)

HSP 1 Score: 136.732 bits (343), Expect = 1.572e-36
Identity = 61/131 (46.56%), Postives = 91/131 (69.47%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            WLK   LKD IEK  +S+RLT SP  L+AS+YGWSGNMERIMK+QAY KS++  Q +  NQKK  EIN +H +I+ L    ++ Q+  +    AK L++TA LRSG+ + +   F++++ ++I+ +M++PL
Sbjct:   91 WLKDKALKDQIEKAVVSQRLTKSPSALVASSYGWSGNMERIMKSQAYSKSQDPTQEFYANQKKTFEINPRHPVIKELLRRVTDDQEDPKALTTAKLLFETATLRSGFALKDQLGFAERIEQVIRQTMEVPL 221

[Close]

BLAST of HATPase_c domain-containing protein vs. TrEMBL
Match: T1EM75 (HATPase_c domain-containing protein OS=Helobdella robusta OX=6412 GN=20197675 PE=3 SV=1)

HSP 1 Score: 143.28 bits (360), Expect = 3.279e-36
Identity = 68/131 (51.91%), Postives = 90/131 (68.70%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LKD IEK  ISERLTTSPC L+AS++GWSGNMERIMK+QAYQK+ +    Y  NQKK LEIN  H LI+ LK      ++   T  LA  L++TA LRSGY + + A F++++  +++ SM +PL
Sbjct:  598 WMKDDALKDKIEKAVISERLTTSPCALVASSFGWSGNMERIMKSQAYQKTNDPNNQYYANQKKTLEINPYHPLIKVLKNRLDTDKENPTTADLAVVLFETATLRSGYSVGDTAQFAERIERMLRLSMNVPL 728

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Cavefish
Match: hsp90b1 (heat shock protein 90, beta (grp94), member 1 [Source:ZFIN;Acc:ZDB-GENE-031002-1])

HSP 1 Score: 128.642 bits (322), Expect = 1.666e-34
Identity = 63/132 (47.73%), Postives = 88/132 (66.67%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRH-LKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            W+K   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++   Y  +QKK LEIN +H LI+  LK    N +D   +  LA  L++TA LRSGY + +  ++ +++  +++ SM + L
Sbjct:  616 WMKDNALKDKIEKAVLSQRLTNSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTLEINPKHPLIKEMLKRVQDNAEDQTAS-DLAVVLFETATLRSGYQLADTKAYGERIERMLRLSMNVDL 746

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Cavefish
Match: hsp90aa1.2 (Astyanax mexicanus heat shock protein HSP 90-alpha 1-like (LOC103024454), mRNA. [Source:RefSeq mRNA;Acc:NM_001291257])

HSP 1 Score: 93.2041 bits (230), Expect = 3.812e-22
Identity = 47/123 (38.21%), Postives = 74/123 (60.16%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L+  +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +     +  KK LEIN  H +I  L+      ++    + L   L++TALL SG+ +D+  + S +++ +IK  + I
Sbjct:  578 LEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHPIIETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLDDPQTHSNRIYRMIKLGLGI 697

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Cavefish
Match: hsp90aa1.2 (Astyanax mexicanus heat shock protein HSP 90-alpha 1-like (LOC103024454), mRNA. [Source:RefSeq mRNA;Acc:NM_001291257])

HSP 1 Score: 93.2041 bits (230), Expect = 3.923e-22
Identity = 47/123 (38.21%), Postives = 74/123 (60.16%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L+  +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +     +  KK LEIN  H +I  L+      ++    + L   L++TALL SG+ +D+  + S +++ +IK  + I
Sbjct:  577 LEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHPIIETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLDDPQTHSNRIYRMIKLGLGI 696

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Cavefish
Match: hsp90ab1 (heat shock protein 90 alpha family class B member 1 [Source:NCBI gene;Acc:103047517])

HSP 1 Score: 91.2781 bits (225), Expect = 1.762e-21
Identity = 46/119 (38.66%), Postives = 73/119 (61.34%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +   Y +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +D+  + S +++ +IK  + I
Sbjct:  575 VEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTM--GYMM-AKKHLEINPDHPIMETLRQKAEADKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGI 690

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Cavefish
Match: hsp90aa1.2 (Astyanax mexicanus heat shock protein HSP 90-alpha 1-like (LOC103024454), mRNA. [Source:RefSeq mRNA;Acc:NM_001291257])

HSP 1 Score: 87.8113 bits (216), Expect = 2.690e-20
Identity = 43/119 (36.13%), Postives = 71/119 (59.66%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            IEKV +S RL  SPC ++ STYGW+ NMERIMK+QA + +  +     +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +++  + + +++ +IK  + I
Sbjct:  574 IEKVTVSNRLVASPCCIVTSTYGWTANMERIMKSQALRDNSTMG---YMTAKKHLEINPLHPIVETLREKAEADKNDKAVKDLVILLFETALLSSGFTLEDPQTHANRIYRMIKLGLGI 689

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Sea Lamprey
Match: hsp90b1 (heat shock protein 90, beta (grp94), member 1 [Source:ZFIN;Acc:ZDB-GENE-031002-1])

HSP 1 Score: 119.013 bits (297), Expect = 7.709e-32
Identity = 55/121 (45.45%), Postives = 78/121 (64.46%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            IEK  +S+RL  SPC L+AS YGWSGNMERIMKAQAYQ  ++    +  +QKK  EIN +H LI+ L       ++    + LA  L++TA LRSGY++ +  SFS ++  +++ S+ I L
Sbjct:  601 IEKATVSQRLLGSPCALVASQYGWSGNMERIMKAQAYQTGKDAASNFYGSQKKTFEINPRHPLIKELLTRVQASEEDATAKDLALVLFETATLRSGYLLQDTRSFSDRIERMLRVSLNIDL 721

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003399.1 (pep scaffold:Pmarinus_7.0:GL479675:6143:15195:1 gene:ENSPMAG00000002912.1 transcript:ENSPMAT00000003399.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 93.2041 bits (230), Expect = 7.309e-23
Identity = 46/119 (38.66%), Postives = 72/119 (60.50%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL  SPC ++ STYGW+ NMERIMKAQA + S  +     +  KK LEIN +H ++  L+      ++    + L   L++TALL SG+ +D+  + S +++ +IK  + I
Sbjct:  553 VEKVTVSNRLVASPCCIVTSTYGWTANMERIMKAQALRDSSTMG---YMAAKKHLEINPEHPIVETLRQKAEADKNDKSVKDLIILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGI 668

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Yeast
Match: HSP82 (Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication [Source:SGD;Acc:S000006161])

HSP 1 Score: 83.9593 bits (206), Expect = 7.135e-20
Identity = 46/124 (37.10%), Postives = 72/124 (58.06%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRK-LAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L D +EKV +S +L  +P  +    +GWS NMERIMKAQA +   +   +  ++ KK  EI+ +  +I+ LK     G   ++T K L K LY+TALL SG+ +D   SF+ +++ +I   + I
Sbjct:  558 LGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALR---DSSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTKLLYETALLTSGFSLDEPTSFASRINRLISLGLNI 678

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Yeast
Match: HSC82 (Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication [Source:SGD;Acc:S000004798])

HSP 1 Score: 78.9518 bits (193), Expect = 4.632e-18
Identity = 43/124 (34.68%), Postives = 71/124 (57.26%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRK-LAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L D +EKV +S +L  +P  +    +GWS NMERIMKAQA +   +   +  ++ KK  EI+ +  +I+ LK     G   ++T K L   L++TALL SG+ ++   SF+ +++ +I   + I
Sbjct:  554 LGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALR---DSSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTNLLFETALLTSGFSLEEPTSFASRINRLISLGLNI 674

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Nematostella
Match: EDO45344 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RT97])

HSP 1 Score: 134.42 bits (337), Expect = 5.863e-37
Identity = 61/131 (46.56%), Postives = 86/131 (65.65%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            WLK   LKD IEK  ISERL  SPC L+AS+YGWSGNMERIM++QAY KS +    Y   QKK LE+N +H L++ L       +D    + L++ L++TA LRSGY++ + A F+ ++  +++ SM + L
Sbjct:  638 WLKEDALKDQIEKATISERLHDSPCALVASSYGWSGNMERIMRSQAYAKSSDPSNEYYATQKKTLEVNPRHPLVKQLLKRVEENKDDQTAKDLSRILFETATLRSGYLVKDSADFAGRIERMLRLSMGVDL 768

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Nematostella
Match: HSP90 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJ66])

HSP 1 Score: 71.2478 bits (173), Expect = 5.513e-15
Identity = 42/119 (35.29%), Postives = 70/119 (58.82%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            IEKV +S RL +SPC ++ S +GW+ NMERIMKAQA + +  +     +  KK LEIN  H+++  L+      ++    + L   LY+T+LL SG+ +++    S +++ +I   + I
Sbjct:  577 IEKVVVSSRLVSSPCCIVTSQFGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHAIMDSLRKKVEADKNDKSLKDLVMLLYETSLLTSGFTLEDPQVHSGRIYRMIGLGLGI 692

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Medaka
Match: hsp90b1 (heat shock protein 90 beta family member 1 [Source:NCBI gene;Acc:101166123])

HSP 1 Score: 133.265 bits (334), Expect = 4.274e-36
Identity = 61/131 (46.56%), Postives = 87/131 (66.41%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPL 393
            WLK   LKD IEK  +S+RLT SPC L+AS YGWSGNMERIMKAQAYQ  +++  +Y  +QKK LEIN +H LI+ +    ++  +      LA  L++TA LRSGY + +  ++  ++  +++ SM +PL
Sbjct:  625 WLKDKALKDKIEKAVLSQRLTDSPCALVASQYGWSGNMERIMKAQAYQTGKDISTSYYASQKKTLEINPKHPLIKQMLGRVNDDAEDQTASDLAVVLFETATLRSGYQLADTKAYGDRIERMLRLSMNVPL 755

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Medaka
Match: hsp90ab1 (heat shock protein 90 alpha family class B member 1 [Source:NCBI gene;Acc:100125466])

HSP 1 Score: 91.6633 bits (226), Expect = 1.179e-21
Identity = 46/119 (38.66%), Postives = 73/119 (61.34%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +   Y +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +D+  + S +++ +IK  + I
Sbjct:  572 VEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTM--GYMM-AKKHLEINPDHPIMETLRQKAETDKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGI 687

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Medaka
Match: hsp90ab1 (heat shock protein 90 alpha family class B member 1 [Source:NCBI gene;Acc:100125466])

HSP 1 Score: 91.6633 bits (226), Expect = 1.220e-21
Identity = 46/119 (38.66%), Postives = 73/119 (61.34%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +   Y +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +D+  + S +++ +IK  + I
Sbjct:  556 VEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTM--GYMM-AKKHLEINPDHPIMETLRQKAETDKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGI 671

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Medaka
Match: hsp90aa1.2 (heat shock protein HSP 90-alpha [Source:NCBI gene;Acc:101169506])

HSP 1 Score: 88.9669 bits (219), Expect = 9.726e-21
Identity = 44/123 (35.77%), Postives = 74/123 (60.16%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L+  +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +     +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +++  + + +++ +IK  + I
Sbjct:  571 LEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHPIMETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLEDPQTHANRIYRMIKLGLGI 690

[Close]

BLAST of HATPase_c domain-containing protein vs. Ensembl Medaka
Match: hsp90aa1.2 (heat shock protein HSP 90-alpha [Source:NCBI gene;Acc:101169506])

HSP 1 Score: 88.9669 bits (219), Expect = 1.011e-20
Identity = 44/123 (35.77%), Postives = 74/123 (60.16%), Query Frame = 1

Query:   19 LKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            L+  +EKV +S RL +SPC ++ STYGW+ NMERIMKAQA + +  +     +  KK LEIN  H ++  L+      ++    + L   L++TALL SG+ +++  + + +++ +IK  + I
Sbjct:  571 LEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMG---YMAAKKHLEINPDHPIMETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLEDPQTHANRIYRMIKLGLGI 690

[Close]

BLAST of HATPase_c domain-containing protein vs. Planmine SMEST
Match: SMESG000054819.1 (SMESG000054819.1)

HSP 1 Score: 334.339 bits (856), Expect = 4.368e-111
Identity = 176/176 (100.00%), Postives = 176/176 (100.00%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPLXXXXXXXXXXXXXTPRQTGTEKLNNENIAPKFDEENKSDKSSAKD 528
            WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPLDDSIIDDEEIIEDTPRQTGTEKLNNENIAPKFDEENKSDKSSAKD
Sbjct:  626 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIPLDDSIIDDEEIIEDTPRQTGTEKLNNENIAPKFDEENKSDKSSAKD 801

[Close]

BLAST of HATPase_c domain-containing protein vs. Planmine SMEST
Match: SMESG000041107.1 (SMESG000041107.1)

HSP 1 Score: 142.124 bits (357), Expect = 2.345e-39
Identity = 66/130 (50.77%), Postives = 90/130 (69.23%), Query Frame = 1

Query:    1 WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKIP 390
            WLK + L + IEK EISERL+TSPC ++ASTYGW+GNMERIMKAQAYQ +      YQ +QKKILEIN +H LI+ LK          + + +A  LY+TA+LRSGY +     F+ ++ +I+++S+ IP
Sbjct:  622 WLKDSVLNEQIEKAEISERLSTSPCAVVASTYGWTGNMERIMKAQAYQSASNSYNEYQSSQKKILEINPKHPLIKELKRQVEKNPTDEKAKDIALTLYETAILRSGYSLPASGGFADRIEKILRSSLNIP 751

[Close]

BLAST of HATPase_c domain-containing protein vs. Planmine SMEST
Match: SMESG000024822.1 (SMESG000024822.1)

HSP 1 Score: 93.5893 bits (231), Expect = 2.320e-22
Identity = 46/119 (38.66%), Postives = 72/119 (60.50%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL +SPC ++ S +GWS NMERIMKAQA + S  +     +  KK LEIN  HS+++ LK      ++    + L   LY+T+LL SG+ +++    + ++H +IK  + I
Sbjct:  566 VEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMG---YMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGI 681

[Close]

BLAST of HATPase_c domain-containing protein vs. Planmine SMEST
Match: SMESG000071533.1 (SMESG000071533.1)

HSP 1 Score: 92.4337 bits (228), Expect = 5.525e-22
Identity = 45/119 (37.82%), Postives = 71/119 (59.66%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL +SPC ++ S +GWS NMERIMKAQA + S  +     +  KK LEIN  HS+++ LK      ++    + L   L++T+LL SG+ +++      ++H +IK  + I
Sbjct:  567 VEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMG---YMAAKKHLEINPDHSIMKSLKLRVDADKNDKSVKDLVMLLFETSLLSSGFSLEDPQVHGNRIHRMIKLGLGI 682

[Close]

BLAST of HATPase_c domain-containing protein vs. Planmine SMEST
Match: SMESG000071531.1 (SMESG000071531.1)

HSP 1 Score: 92.0485 bits (227), Expect = 6.052e-22
Identity = 45/119 (37.82%), Postives = 71/119 (59.66%), Query Frame = 1

Query:   31 IEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSMKI 387
            +EKV +S RL +SPC ++ S +GWS NMERIMKAQA + S  +     +  KK LEIN  HS+++ LK      ++    + L   L++T+LL SG+ +++      ++H +IK  + I
Sbjct:  548 VEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMG---YMAAKKHLEINPDHSIMKSLKLRVDADKNDKSVKDLVMLLFETSLLSSGFSLEDPQVHGNRIHRMIKLGLGI 663

The following BLAST results are available for this feature:

BLAST of HATPase_c domain-containing protein vs. Ensembl Human
BLAST of HATPase_c domain-containing protein vs. Ensembl Celegans
BLAST of HATPase_c domain-containing protein vs. Ensembl Fly
BLAST of HATPase_c domain-containing protein vs. Ensembl Zebrafish
BLAST of HATPase_c domain-containing protein vs. Ensembl Xenopus
BLAST of HATPase_c domain-containing protein vs. Ensembl Mouse
BLAST of HATPase_c domain-containing protein vs. UniProt/SwissProt
BLAST of HATPase_c domain-containing protein vs. TrEMBL
BLAST of HATPase_c domain-containing protein vs. Ensembl Cavefish
BLAST of HATPase_c domain-containing protein vs. Ensembl Sea Lamprey
BLAST of HATPase_c domain-containing protein vs. Ensembl Yeast
BLAST of HATPase_c domain-containing protein vs. Ensembl Nematostella
BLAST of HATPase_c domain-containing protein vs. Ensembl Medaka
BLAST of HATPase_c domain-containing protein vs. Planmine SMEST

BLAST of HATPase_c domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HSP90B1	1.179e-34	45.74	heat shock protein 90 beta family member 1 [Source...	[more]
HSP90B1	1.365e-23	41.84	heat shock protein 90 beta family member 1 [Source...	[more]
HSP90AA1	4.354e-22	39.02	heat shock protein 90 alpha family class A member ...	[more]
HSP90AA1	5.946e-22	39.02	heat shock protein 90 alpha family class A member ...	[more]
HSP90AB1	6.730e-21	38.66	heat shock protein 90 alpha family class B member ...	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
enpl-1	2.254e-32	42.64	Endoplasmin homolog [Source:UniProtKB/Swiss-Prot;...	[more]
enpl-1	2.254e-32	42.64	Endoplasmin homolog [Source:UniProtKB/Swiss-Prot;...	[more]
enpl-1	2.254e-32	42.64	Endoplasmin homolog [Source:UniProtKB/Swiss-Prot;...	[more]
enpl-1	2.254e-32	42.64	Endoplasmin homolog [Source:UniProtKB/Swiss-Prot;...	[more]
enpl-1	2.254e-32	42.64	Endoplasmin homolog [Source:UniProtKB/Swiss-Prot;...	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Gp93	3.193e-31	38.76	gene:FBgn0039562 transcript:FBtr0085254	[more]
Hsp83	9.278e-20	34.96	gene:FBgn0001233 transcript:FBtr0332873	[more]
Hsp83	9.278e-20	34.96	gene:FBgn0001233 transcript:FBtr0073040	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hsp90b1	1.862e-33	44.27	heat shock protein 90, beta (grp94), member 1 [Sou...	[more]
hsp90b1	2.120e-33	44.27	heat shock protein 90, beta (grp94), member 1 [Sou...	[more]
hsp90aa1.2	7.722e-22	37.82	heat shock protein 90, alpha (cytosolic), class A ...	[more]
hsp90ab1	2.224e-21	38.66	heat shock protein 90, alpha (cytosolic), class A ...	[more]
hsp90ab1	2.224e-21	38.66	heat shock protein 90, alpha (cytosolic), class A ...	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hsp90b1	1.100e-34	46.56	heat shock protein 90kDa beta (Grp94), member 1 [S...	[more]
hsp90b1	1.418e-34	46.56	heat shock protein 90kDa beta (Grp94), member 1 [S...	[more]
hsp90b1	1.510e-34	46.56	heat shock protein 90kDa beta (Grp94), member 1 [S...	[more]
hsp90b1	1.575e-34	46.56	heat shock protein 90kDa beta (Grp94), member 1 [S...	[more]
hsp90b1	4.227e-33	46.56	heat shock protein 90kDa beta (Grp94), member 1 [S...	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hsp90b1	6.535e-35	45.74	heat shock protein 90, beta (Grp94), member 1 [Sou...	[more]
Hsp90b1	1.060e-26	59.74	heat shock protein 90, beta (Grp94), member 1 [Sou...	[more]
Hsp90aa1	3.967e-22	39.02	heat shock protein 90, alpha (cytosolic), class A ...	[more]
Hsp90aa1	3.967e-22	39.02	heat shock protein 90, alpha (cytosolic), class A ...	[more]
Hsp90ab1	4.446e-21	38.66	heat shock protein 90 alpha (cytosolic), class B m...	[more]

BLAST of HATPase_c domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P08712\|ENPL_MESAU	2.876e-35	45.74	Endoplasmin (Fragment) OS=Mesocricetus auratus OX=...	[more]
sp\|Q95M18\|ENPL_BOVIN	4.446e-34	45.74	Endoplasmin OS=Bos taurus OX=9913 GN=HSP90B1 PE=2 ...	[more]
sp\|P08113\|ENPL_MOUSE	4.571e-34	45.74	Endoplasmin OS=Mus musculus OX=10090 GN=Hsp90b1 PE...	[more]
sp\|Q29092\|ENPL_PIG	5.294e-34	45.74	Endoplasmin OS=Sus scrofa OX=9823 GN=HSP90B1 PE=2 ...	[more]
sp\|Q5R6F7\|ENPL_PONAB	5.611e-34	45.74	Endoplasmin OS=Pongo abelii OX=9601 GN=HSP90B1 PE=...	[more]

BLAST of HATPase_c domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A2R4NBU5	6.122e-68	72.73	Heat shock protein 902 OS=Dugesia japonica OX=6161...	[more]
R7U2A8	1.934e-39	51.15	HATPase_c domain-containing protein OS=Capitella t...	[more]
A0A2T7NSL7	8.781e-37	49.62	HATPase_c domain-containing protein OS=Pomacea can...	[more]
A0A0N4UU82	1.572e-36	46.56	Uncharacterized protein OS=Enterobius vermicularis...	[more]
T1EM75	3.279e-36	51.91	HATPase_c domain-containing protein OS=Helobdella ...	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hsp90b1	1.666e-34	47.73	heat shock protein 90, beta (grp94), member 1 [Sou...	[more]
hsp90aa1.2	3.812e-22	38.21	Astyanax mexicanus heat shock protein HSP 90-alpha...	[more]
hsp90aa1.2	3.923e-22	38.21	Astyanax mexicanus heat shock protein HSP 90-alpha...	[more]
hsp90ab1	1.762e-21	38.66	heat shock protein 90 alpha family class B member ...	[more]
hsp90aa1.2	2.690e-20	36.13	Astyanax mexicanus heat shock protein HSP 90-alpha...	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
hsp90b1	7.709e-32	45.45	heat shock protein 90, beta (grp94), member 1 [Sou...	[more]
ENSPMAT00000003399.1	7.309e-23	38.66	pep scaffold:Pmarinus_7.0:GL479675:6143:15195:1 ge...	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
HSP82	7.135e-20	37.10	Hsp90 chaperone; redundant in function with Hsc82p...	[more]
HSC82	4.632e-18	34.68	Cytoplasmic chaperone of the Hsp90 family; plays a...	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO45344	5.863e-37	46.56	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
HSP90	5.513e-15	35.29	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of HATPase_c domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hsp90b1	4.274e-36	46.56	heat shock protein 90 beta family member 1 [Source...	[more]
hsp90ab1	1.179e-21	38.66	heat shock protein 90 alpha family class B member ...	[more]
hsp90ab1	1.220e-21	38.66	heat shock protein 90 alpha family class B member ...	[more]
hsp90aa1.2	9.726e-21	35.77	heat shock protein HSP 90-alpha [Source:NCBI gene;...	[more]
hsp90aa1.2	1.011e-20	35.77	heat shock protein HSP 90-alpha [Source:NCBI gene;...	[more]

BLAST of HATPase_c domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000054819.1	4.368e-111	100.00	SMESG000054819.1	[more]
SMESG000041107.1	2.345e-39	50.77	SMESG000041107.1	[more]
SMESG000024822.1	2.320e-22	38.66	SMESG000024822.1	[more]
SMESG000071533.1	5.525e-22	37.82	SMESG000071533.1	[more]
SMESG000071531.1	6.052e-22	37.82	SMESG000071531.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30008204 ID=SMED30008204|Name=HATPase_c domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=529bp
TGGTTGAAAAGTACCGAACTGAAGGACTATATAGAAAAAGTGGAAATATC
CGAAAGACTCACCACCAGTCCTTGCGTATTGATTGCGTCAACATATGGCT
GGTCCGGTAACATGGAGAGAATCATGAAAGCTCAAGCTTATCAGAAATCC
GAGGAAGTCATGCAAACCTATCAAGTAAACCAAAAGAAAATTTTAGAAAT
CAACACACAACATTCTTTGATAAGACATTTGAAATACTCGTTTTCCAACG
GGCAAGACATGAATGAAACAAGAAAATTGGCGAAATTCCTATACGACACA
GCTTTGTTGCGATCAGGGTATATAATGGACAATGTCGCAAGCTTTTCTAA
ACAAGTCCATGAAATCATTAAAACCTCAATGAAAATCCCGCTTGATGATT
CCATAATTGATGACGAAGAGATTATTGAAGATACCCCTCGACAAACGGGA
ACAGAAAAGTTGAATAATGAAAATATTGCACCGAAATTTGATGAAGAAAA
CAAATCTGATAAATCTTCTGCCAAGGATG

protein sequence of SMED30008204-orf-1

>SMED30008204-orf-1 ID=SMED30008204-orf-1|Name=SMED30008204-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=176bp
WLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKS
EEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDT
ALLRSGYIMDNVASFSKQVHEIIKTSMKIPLDDSIIDDEEIIEDTPRQTG
TEKLNNENIAPKFDEENKSDKSSAKD

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002089	reproductive organ
PLANA:0003304	testis primordium

Vocabulary: **INTERPRO**
Term	Definition
IPR037196	HSP90_C
IPR001404	Hsp90_fam

Vocabulary: **biological process**
Term	Definition
GO:0006950	response to stress
GO:0006457	protein folding

Vocabulary: **molecular function**
Term	Definition
GO:0051082	unfolded protein binding
GO:0005524	ATP binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001404	Heat shock protein Hsp90 family	PFAM	PF00183	HSP90	coord: 1..148 e-value: 1.9E-41 score: 142.6
IPR001404	Heat shock protein Hsp90 family	PANTHER	PTHR11528	HEAT SHOCK PROTEIN 90 FAMILY MEMBER	coord: 1..172
IPR037196	HSP90, C-terminal domain	GENE3D	G3DSA:1.20.120.790		coord: 1..128 e-value: 2.1E-42 score: 146.4
IPR037196	HSP90, C-terminal domain	SUPERFAMILY	SSF110942	HSP90 C-terminal domain	coord: 6..123
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 158..176
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 141..176
None	No IPR available	PANTHER	PTHR11528:SF96	ENDOPLASMIN	coord: 1..172