Non-specific serine/threonine protein kinase

Overview
NameNon-specific serine/threonine protein kinase
Smed IDSMED30008195
Length (bp)1731
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Non-specific serine/threonine protein kinase (SMED30008195) t-SNE clustered cells

Violin plots show distribution of expression levels for Non-specific serine/threonine protein kinase (SMED30008195) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Non-specific serine/threonine protein kinase (SMED30008195) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Non-specific serine/threonine protein kinase (SMED30008195) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30008195

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30008195h1SMcG0001660 dd_Smed_v4_10848_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30008195h1SMcG0001660 dd_Smed_v4_10848_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30008195h1SMcG0001660 dd_Smed_v4_10848_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
photoreceptor neuronSMED30008195h1SMcG0001660 SMED30008195smed_20140614PMID:22884275
Lapan et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
epidermisSMED30008195h1SMcG0001660 dd_Smed_v4_10848_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: PAK4 (p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059])

HSP 1 Score: 369.777 bits (948), Expect = 1.276e-121
Identity = 213/507 (42.01%), Postives = 297/507 (58.58%), Query Frame = 3 
Query:   51 DISKPEKFRHVWHVEFKNGH--FKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIV-GSYRLPSGQSS----NRQSITIVNSNSLHKTSSNNNRETKKSNQLIDKXXXXXXXXXXX-XXYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRTPSQHRVLRKSN-LSIHSDSALLRSKSVIELSDQNSSSGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEK 1544
            +IS P  F H  H  F      F GLP QW +L++E      P+VD + ITS +    K IV GS     G  +      +++++  SNSL + S       ++ N + ++    +       + +D +   N  +   ++        I  +SS   R P++ R       L  H+    L   +    +          S ++   + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C ++L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLGIMVIEMVD EPPYF E PL+AMK IRD  P   ++  ++ P L+ FLD LL++D  +R  A++LL+HPF     P   SI+ L+ +
Sbjct:   10 EISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKGEPHDVA--PNGPSAGGLA--------IPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA-----TVRSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA-SIVPLMRQ 497
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: PAK4 (p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059])

HSP 1 Score: 350.517 bits (898), Expect = 5.151e-115
Identity = 169/306 (55.23%), Postives = 221/306 (72.22%), Query Frame = 3 
Query:  627 SLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEK 1544
            S ++   + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C ++L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLGIMVIEMVD EPPYF E PL+AMK IRD  P   ++  ++ P L+ FLD LL++D  +R  A++LL+HPF     P   SI+ L+ +
Sbjct:  138 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA-----TVRSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA-SIVPLMRQ 434
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: PAK4 (p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059])

HSP 1 Score: 350.517 bits (898), Expect = 5.151e-115
Identity = 169/306 (55.23%), Postives = 221/306 (72.22%), Query Frame = 3 
Query:  627 SLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEK 1544
            S ++   + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C ++L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLGIMVIEMVD EPPYF E PL+AMK IRD  P   ++  ++ P L+ FLD LL++D  +R  A++LL+HPF     P   SI+ L+ +
Sbjct:  138 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA-----TVRSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA-SIVPLMRQ 434
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: PAK4 (p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059])

HSP 1 Score: 353.984 bits (907), Expect = 2.494e-114
Identity = 168/299 (56.19%), Postives = 218/299 (72.91%), Query Frame = 3 
Query:  648 QYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEK 1544
            + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C ++L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLGIMVIEMVD EPPYF E PL+AMK IRD  P   ++  ++ P L+ FLD LL++D  +R  A++LL+HPF     P   SI+ L+ +
Sbjct:  298 RVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA-----TVRSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA-SIVPLMRQ 587
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Match: PAK4 (p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059])

HSP 1 Score: 353.984 bits (907), Expect = 2.494e-114
Identity = 168/299 (56.19%), Postives = 218/299 (72.91%), Query Frame = 3 
Query:  648 QYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEK 1544
            + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C ++L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLGIMVIEMVD EPPYF E PL+AMK IRD  P   ++  ++ P L+ FLD LL++D  +R  A++LL+HPF     P   SI+ L+ +
Sbjct:  298 RVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA-----TVRSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA-SIVPLMRQ 587
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: pak-2 (Serine/threonine-protein kinase pak-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EFU0])

HSP 1 Score: 331.643 bits (849), Expect = 4.078e-107
Identity = 201/500 (40.20%), Postives = 285/500 (57.00%), Query Frame = 3 
Query:   54 ISKPEKFRHVWHVEF--KNGHFKGLPPQWINLV-KEKPGSR-DPVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNRQSITIVNSNSLHKTSSNNNRETKKSNQLIDKXXXXXXXXXXXXXYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLE 1541
            IS P  F H  H  F  ++G + GLP QW  L+   +  SR  P+VD S IT  +    K ++   R PS + ++     + NS       SN+ R +  ++ +++ ++       T      S      N  + +   +  ++   +++  +  P Q++ +        + +  L+ KS        S+        K     +DEEFR A+K +V+  DPR  L + K+IG+GSTGVV         +S K    + VA+K+MNL  QQRRELLFNEV  +R Y H NIV  F S+LV DELWVVME+++GG+LTDIVT  R+   +I TI + +L ALD+LH   VIHRDIKSD+ILL R G +KL+DFGFC Q+S +VPRR SLVGTPYW A EVI+R+PY+T  DIWS GIM+IEMV+ EPP+F ++P +AMK+IRD        + ++  EL   L   ++KD  +R  A DLLRHPFF   Q S+    +LL+
Sbjct:   16 ISTPSNFEHRIHAGFDARSGTYTGLPKQWQALLGPPRSISRPKPMVDPSCITPVDVAELKTVI---RGPSSRYNSPLPFGMTNSPMPSVARSNSLRISATASPVVNVSSARHSFRPTLPPV--SQRGYPFNDPSYAPLPLRNQKPPMSTTFGVEKPHQYQQIITIVAPSRTTTPQLQPKS-------PSTPQAMRQQPKCTEGVSDEEFRNALKFVVDGTDPRSDLTDYKQIGEGSTGVV----EAAYKISTK----QIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFFAKAQHSSSIAPLLLQ 495
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: pak-2 (Serine/threonine-protein kinase pak-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EFU0])

HSP 1 Score: 331.643 bits (849), Expect = 4.813e-107
Identity = 206/508 (40.55%), Postives = 284/508 (55.91%), Query Frame = 3 
Query:   54 ISKPEKFRHVWHVEF--KNGHFKGLPPQWINLV-KEKPGSR-DPVVDKSKITSSEAVPFKQIV----GSYR----LPSGQSSNRQSITIVNSNSLHKTSSNNNRETKKSNQLIDKXXXXXXXXXXXXXYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLE 1541
            IS P  F H  H  F  ++G + GLP QW  L+   +  SR  P+VD S IT  +    K ++     S+R    LP G + N    ++  SNSL  +++ +      S +   +     +S       D S+       Q   M          +++  +  P Q++ +        + +  L+ KS        S+        K     +DEEFR A+K +V+  DPR  L + K+IG+GSTGVV         +S K    + VA+K+MNL  QQRRELLFNEV  +R Y H NIV  F S+LV DELWVVME+++GG+LTDIVT  R+   +I TI + +L ALD+LH   VIHRDIKSD+ILL R G +KL+DFGFC Q+S +VPRR SLVGTPYW A EVI+R+PY+T  DIWS GIM+IEMV+ EPP+F ++P +AMK+IRD        + ++  EL   L   ++KD  +R  A DLLRHPFF   Q S+    +LL+
Sbjct:   16 ISTPSNFEHRIHAGFDARSGTYTGLPKQWQALLGPPRSISRPKPMVDPSCITPVDVAELKTVIRGPSSSFRYNSPLPFGMT-NSPMPSVARSNSLRISATASPVVNVSSARHSFRPTLPPVSQRGYPFNDPSYAPLPLRNQKPPM----------STTFGVEKPHQYQQIITIVAPSRTTTPQLQPKS-------PSTPQAMRQQPKCTEGVSDEEFRNALKFVVDGTDPRSDLTDYKQIGEGSTGVV----EAAYKISTK----QIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFFAKAQHSSSIAPLLLQ 497
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: pak-1 (Serine/threonine-protein kinase pak-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17850])

HSP 1 Score: 270.396 bits (690), Expect = 1.803e-83
Identity = 136/293 (46.42%), Postives = 185/293 (63.14%), Query Frame = 3 
Query:  633 KKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQP 1511
            +K+  + TD E    ++ IV+  +P R  +++ KIG G++G V+    T   +S + +    VAIK+MNL +Q ++EL+ NE+L MR   H NIV    SYLV DELWVVMEYL GG+LTD+VT  ++E   I  +C+ +L AL++LH   VIHRDIKSD ILL   G +KL+DFGFCAQ+S +  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM IEMV+ EPPY  E PL A+  I           D M    + F+DS L      R  AS LL HPF +  +P
Sbjct:  218 QKAKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVY----TAIEISTEAE----VAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLRCAKP 502
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: pak-1 (Serine/threonine-protein kinase pak-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17850])

HSP 1 Score: 270.396 bits (690), Expect = 5.670e-83
Identity = 136/293 (46.42%), Postives = 185/293 (63.14%), Query Frame = 3 
Query:  633 KKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQP 1511
            +K+  + TD E    ++ IV+  +P R  +++ KIG G++G V+    T   +S + +    VAIK+MNL +Q ++EL+ NE+L MR   H NIV    SYLV DELWVVMEYL GG+LTD+VT  ++E   I  +C+ +L AL++LH   VIHRDIKSD ILL   G +KL+DFGFCAQ+S +  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM IEMV+ EPPY  E PL A+  I           D M    + F+DS L      R  AS LL HPF +  +P
Sbjct:  264 QKAKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVY----TAIEISTEAE----VAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLRCAKP 548
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Match: pak-1 (Serine/threonine-protein kinase pak-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17850])

HSP 1 Score: 270.011 bits (689), Expect = 7.863e-83
Identity = 136/293 (46.42%), Postives = 185/293 (63.14%), Query Frame = 3 
Query:  633 KKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQP 1511
            +K+  + TD E    ++ IV+  +P R  +++ KIG G++G V+    T   +S + +    VAIK+MNL +Q ++EL+ NE+L MR   H NIV    SYLV DELWVVMEYL GG+LTD+VT  ++E   I  +C+ +L AL++LH   VIHRDIKSD ILL   G +KL+DFGFCAQ+S +  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM IEMV+ EPPY  E PL A+  I           D M    + F+DS L      R  AS LL HPF +  +P
Sbjct:  267 QKAKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVY----TAIEISTEAE----VAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLRCAKP 551
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: mbt (gene:FBgn0025743 transcript:FBtr0074285)

HSP 1 Score: 360.533 bits (924), Expect = 1.215e-116
Identity = 166/300 (55.33%), Postives = 220/300 (73.33%), Query Frame = 3 
Query:  636 KSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILML 1535
            K D + T E+FR A++ +V+  DPR  L    KIG+GSTG V ++ +            R VA+KKM+L  QQRRELLFNEV+ MR+Y H NIVET+ S+LV DELWVVMEYL+GG LTDIVT  R++ ++I T+CK  L AL YLH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S ++P+R SLVGTPYWM+PEVISR PY   +DIWSLGIMVIEMVD EPP+F E PL+AM++IRD+ P + ++  ++ P LQ+FLD +L++D  +R  A++LL HPF +   P +  + ++
Sbjct:  341 KQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDK--------STGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLM 632
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334539)

HSP 1 Score: 289.271 bits (739), Expect = 1.298e-88
Identity = 138/288 (47.92%), Postives = 191/288 (66.32%), Query Frame = 3 
Query:  648 QYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQP 1511
            + +DEE  E ++ IV+  DP R   +++KIGQG++G V+ +     I S+ G     VAIK+MNL  Q ++EL+ NE+L MR   H N+V    SYLV +ELWVVMEYL GG+LTD+VT   ++  +I  +C+ +L AL++LH + VIHRDIKSD ILL   G +KL+DFGFCAQIS +  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM IEMV+ EPPY  E PL+A+  I        +  D++    Q FLD  L  +  RR  A DLL+HPF ++ +P
Sbjct:  407 KMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTA-----IESSTG---MEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARP 686
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081714)

HSP 1 Score: 289.271 bits (739), Expect = 1.298e-88
Identity = 138/288 (47.92%), Postives = 191/288 (66.32%), Query Frame = 3 
Query:  648 QYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQP 1511
            + +DEE  E ++ IV+  DP R   +++KIGQG++G V+ +     I S+ G     VAIK+MNL  Q ++EL+ NE+L MR   H N+V    SYLV +ELWVVMEYL GG+LTD+VT   ++  +I  +C+ +L AL++LH + VIHRDIKSD ILL   G +KL+DFGFCAQIS +  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM IEMV+ EPPY  E PL+A+  I        +  D++    Q FLD  L  +  RR  A DLL+HPF ++ +P
Sbjct:  407 KMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTA-----IESSTG---MEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARP 686
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081716)

HSP 1 Score: 289.271 bits (739), Expect = 1.298e-88
Identity = 138/288 (47.92%), Postives = 191/288 (66.32%), Query Frame = 3 
Query:  648 QYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQP 1511
            + +DEE  E ++ IV+  DP R   +++KIGQG++G V+ +     I S+ G     VAIK+MNL  Q ++EL+ NE+L MR   H N+V    SYLV +ELWVVMEYL GG+LTD+VT   ++  +I  +C+ +L AL++LH + VIHRDIKSD ILL   G +KL+DFGFCAQIS +  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM IEMV+ EPPY  E PL+A+  I        +  D++    Q FLD  L  +  RR  A DLL+HPF ++ +P
Sbjct:  407 KMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTA-----IESSTG---MEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARP 686
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081715)

HSP 1 Score: 289.271 bits (739), Expect = 1.298e-88
Identity = 138/288 (47.92%), Postives = 191/288 (66.32%), Query Frame = 3 
Query:  648 QYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQP 1511
            + +DEE  E ++ IV+  DP R   +++KIGQG++G V+ +     I S+ G     VAIK+MNL  Q ++EL+ NE+L MR   H N+V    SYLV +ELWVVMEYL GG+LTD+VT   ++  +I  +C+ +L AL++LH + VIHRDIKSD ILL   G +KL+DFGFCAQIS +  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM IEMV+ EPPY  E PL+A+  I        +  D++    Q FLD  L  +  RR  A DLL+HPF ++ +P
Sbjct:  407 KMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTA-----IESSTG---MEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARP 686
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: pak6b (p21 protein (Cdc42/Rac)-activated kinase 6b [Source:ZFIN;Acc:ZDB-GENE-041014-121])

HSP 1 Score: 357.451 bits (916), Expect = 8.440e-116
Identity = 172/319 (53.92%), Postives = 230/319 (72.10%), Query Frame = 3 
Query:  600 QNSSSGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPF-FQITQPSTRSILMLLEKYNK 1553
            Q  S  + P L  ++   T  +FR A++ +V+P DPR YL+   KIG+GSTGVV         ++ +    R VA+K M+L  QQRRELLFNEV+ MR+Y H N+VE + S LV +ELWV+MEYL GG LT+IV+  RL  ++I T+C+S+L AL YLH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQIS DVP+R SLVGTPYWMAPEV+S+ PY T +DIWSLGIMV+EMVD EPPYF E P+ AMK++RD  P ++R+  ++ P L+ FLDS+L ++ ++R  ASDLL+HPF  Q + P  R ++ L+E+  +
Sbjct:  296 QAPSGASSPGL--TEPSVTHTQFRAALQMVVDPGDPRSYLENFIKIGEGSTGVV--------CIAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYRHQNVVEMYKSALVGEELWVIMEYLQGGALTNIVSETRLTEEQIATVCESVLQALCYLHSQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRRSLVGTPYWMAPEVVSKTPYGTEVDIWSLGIMVVEMVDGEPPYFSETPISAMKRLRDEPPPTARNASKISPVLRDFLDSMLTREPQQRSSASDLLQHPFLLQCSSP--RCLIPLVEQTRR 602
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: pak6b (p21 protein (Cdc42/Rac)-activated kinase 6b [Source:ZFIN;Acc:ZDB-GENE-041014-121])

HSP 1 Score: 357.451 bits (916), Expect = 8.440e-116
Identity = 172/319 (53.92%), Postives = 230/319 (72.10%), Query Frame = 3 
Query:  600 QNSSSGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPF-FQITQPSTRSILMLLEKYNK 1553
            Q  S  + P L  ++   T  +FR A++ +V+P DPR YL+   KIG+GSTGVV         ++ +    R VA+K M+L  QQRRELLFNEV+ MR+Y H N+VE + S LV +ELWV+MEYL GG LT+IV+  RL  ++I T+C+S+L AL YLH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQIS DVP+R SLVGTPYWMAPEV+S+ PY T +DIWSLGIMV+EMVD EPPYF E P+ AMK++RD  P ++R+  ++ P L+ FLDS+L ++ ++R  ASDLL+HPF  Q + P  R ++ L+E+  +
Sbjct:  296 QAPSGASSPGL--TEPSVTHTQFRAALQMVVDPGDPRSYLENFIKIGEGSTGVV--------CIAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYRHQNVVEMYKSALVGEELWVIMEYLQGGALTNIVSETRLTEEQIATVCESVLQALCYLHSQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRRSLVGTPYWMAPEVVSKTPYGTEVDIWSLGIMVVEMVDGEPPYFSETPISAMKRLRDEPPPTARNASKISPVLRDFLDSMLTREPQQRSSASDLLQHPFLLQCSSP--RCLIPLVEQTRR 602
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: pak6a (p21 protein (Cdc42/Rac)-activated kinase 6a [Source:ZFIN;Acc:ZDB-GENE-130410-1])

HSP 1 Score: 348.977 bits (894), Expect = 1.887e-111
Identity = 166/302 (54.97%), Postives = 219/302 (72.52%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKYL 1559
            T E+F+ A++ +V+  DPR YL+   KIG+GSTGVV         ++ +    R VA+K M+L  QQRRELLFNEV+ MR+Y H N+VE F S LV++ELWV+MEYL GG LT+IV+  RL  ++I T+C+++L AL YLH  GVIHRDIKSD+ILLS  G+IKLSDFGFCAQIS D+P+R SLVGTPYWMAPEVIS+ PY T +D+WSLGIMV+EMVD EPPYF E P+ AMK++RD    + R+  ++ P L+ FLD +L +D   R  A+DLL HPF  +   S + ++ L+E+Y K +
Sbjct:  398 THEQFKAALQMVVDKGDPRSYLENFVKIGEGSTGVV--------CIAREKHSGRVVAVKMMDLRRQQRRELLFNEVVIMRDYQHRNVVEMFKSALVEEELWVIMEYLQGGALTNIVSETRLSEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLSLDGRIKLSDFGFCAQISKDIPKRKSLVGTPYWMAPEVISKSPYGTEVDVWSLGIMVVEMVDGEPPYFSETPVAAMKRLRDELAPTVRNVHQVSPMLKDFLDRMLTRDPLERASATDLLEHPFL-LQASSPQCLVPLVEQYRKRM 690

HSP 2 Score: 52.373 bits (124), Expect = 1.221e-6
Identity = 38/112 (33.93%), Postives = 57/112 (50.89%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVK--EKPGSRDPVVDKSKITSSEAVPFKQIV-----GSYRLPSGQSSNRQSITIVNSNSLHKTSSNNNRETKKSNQL 353
            + +IS P+ F H  H  F  K G F GLP QW +L++   +P    P+VD S+IT  E  P K IV     G     S   S+   +++ +SNSL K+S +  +  +   +L
Sbjct:    9 RPEISAPKNFEHRVHTSFDAKRGVFVGLPTQWQSLIENLRRP---KPMVDPSRITPVELKPKKTIVRGSMIGHGDYISAMLSDMSRLSVTSSNSLRKSSPSARKRAQSLGRL 117
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: pak6a (p21 protein (Cdc42/Rac)-activated kinase 6a [Source:ZFIN;Acc:ZDB-GENE-130410-1])

HSP 1 Score: 342.428 bits (877), Expect = 3.799e-110
Identity = 179/392 (45.66%), Postives = 248/392 (63.27%), Query Frame = 3 
Query:  414 HLKNNQNKQTISME-RVLQKRITGNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLK--KSDGQYTDEEFR-------EAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKYL 1559
            H +N+  +   S + +V+   +  + ++  R P+    +R S L    DS      S       +      P+ +  +     T E+F+        A++ +V+  DPR YL+   KIG+GSTGVV         ++ +    R VA+K M+L  QQRRELLFNEV+ MR+Y H N+VE F S LV++ELWV+MEYL GG LT+IV+  RL  ++I T+C+++L AL YLH  GVIHRDIKSD+ILLS  G+IKLSDFGFCAQIS D+P+R SLVGTPYWMAPEVIS+ PY T +D+WSLGIMV+EMVD EPPYF E P+ AMK++RD    + R+  ++ P L+ FLD +L +D   R  A+DLL HPF  +   S + ++ L+E+Y K +
Sbjct:  208 HPQNSPGRPFSSYDLKVIHYTLGLSPNISYRPPAPDPFMRHSGLYPRQDSPSQPRPSPTGSLAHSPPGTCSPAFRAPQQPSPLTHEQFKVDHCQIQAALQMVVDKGDPRSYLENFVKIGEGSTGVV--------CIAREKHSGRVVAVKMMDLRRQQRRELLFNEVVIMRDYQHRNVVEMFKSALVEEELWVIMEYLQGGALTNIVSETRLSEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLSLDGRIKLSDFGFCAQISKDIPKRKSLVGTPYWMAPEVISKSPYGTEVDVWSLGIMVVEMVDGEPPYFSETPVAAMKRLRDELAPTVRNVHQVSPMLKDFLDRMLTRDPLERASATDLLEHPFL-LQASSPQCLVPLVEQYRKRM 590

HSP 2 Score: 52.373 bits (124), Expect = 1.342e-6
Identity = 38/112 (33.93%), Postives = 57/112 (50.89%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVK--EKPGSRDPVVDKSKITSSEAVPFKQIV-----GSYRLPSGQSSNRQSITIVNSNSLHKTSSNNNRETKKSNQL 353
            + +IS P+ F H  H  F  K G F GLP QW +L++   +P    P+VD S+IT  E  P K IV     G     S   S+   +++ +SNSL K+S +  +  +   +L
Sbjct:    9 RPEISAPKNFEHRVHTSFDAKRGVFVGLPTQWQSLIENLRRP---KPMVDPSRITPVELKPKKTIVRGSMIGHGDYISAMLSDMSRLSVTSSNSLRKSSPSARKRAQSLGRL 117
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69])

HSP 1 Score: 344.739 bits (883), Expect = 4.201e-110
Identity = 167/298 (56.04%), Postives = 216/298 (72.48%), Query Frame = 3 
Query:  660 EEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNK 1553
            E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V   G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +V RR SLVGTPYWMAPE+ISR PY   +DIWS GIMVIEMVD EPPYF E PL+AMK IRD  P   ++  ++ P L+ FLD +L++D  +R  A +LL+HPF  +T+    S ++ L + N+
Sbjct:  375 EQFRAALQMVVDPGDPRTYLDHYIKIGEGSTGIVCIA-----TVKTTG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQISTVCLSVLKALSVLHSQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVQRRKSLVGTPYWMAPELISRLPYGPEVDIWSFGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNLHKVSPLLKGFLDRMLVRDPAQRATAQELLKHPF--LTKAGPPSCIVPLMRQNR 662
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: bri3bp (BRI3 binding protein [Source:Xenbase;Acc:XB-GENE-943691])

HSP 1 Score: 354.369 bits (908), Expect = 3.117e-113
Identity = 166/301 (55.15%), Postives = 222/301 (73.75%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            + E+FR A++ +V+P DPR YL +  KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEM+D EPPYF E PL+AM++IRD  P   +   ++   L+ FLD +L+++  +R  A +LLRHPF +++ P +  I+ L+ +Y  +
Sbjct:  411 SHEQFRAALQLVVSPGDPREYLDDFIKIGEGSTGIV--------CIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRVKDVHQVSSVLRGFLDLMLVREPSQRATAQELLRHPFLKLSGPPS-CIIPLMRQYRHH 702

HSP 2 Score: 52.7582 bits (125), Expect = 1.646e-6
Identity = 37/102 (36.27%), Postives = 48/102 (47.06%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLP-----SGQSSNRQSITIVNSNSLHKTSSNNNR 329
            K DIS P  F H  H  F  K   F GLP QW +L+ +      P+VD S IT  +  P K IV   + P     +G   +  +I++  SNSL K S    R
Sbjct:    8 KLDISGPSNFEHRVHTGFDHKEQKFIGLPQQWQSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGSKPPQDAYINGLLEDFDNISVTRSNSLRKESPPTPR 109
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: bri3bp (BRI3 binding protein [Source:Xenbase;Acc:XB-GENE-943691])

HSP 1 Score: 353.984 bits (907), Expect = 3.258e-113
Identity = 166/301 (55.15%), Postives = 222/301 (73.75%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            + E+FR A++ +V+P DPR YL +  KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEM+D EPPYF E PL+AM++IRD  P   +   ++   L+ FLD +L+++  +R  A +LLRHPF +++ P +  I+ L+ +Y  +
Sbjct:  409 SHEQFRAALQLVVSPGDPREYLDDFIKIGEGSTGIV--------CIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRVKDVHQVSSVLRGFLDLMLVREPSQRATAQELLRHPFLKLSGPPS-CIIPLMRQYRHH 700

HSP 2 Score: 52.373 bits (124), Expect = 2.166e-6
Identity = 36/100 (36.00%), Postives = 47/100 (47.00%), Query Frame = 3 
Query:   51 DISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLP-----SGQSSNRQSITIVNSNSLHKTSSNNNR 329
            DIS P  F H  H  F  K   F GLP QW +L+ +      P+VD S IT  +  P K IV   + P     +G   +  +I++  SNSL K S    R
Sbjct:   22 DISGPSNFEHRVHTGFDHKEQKFIGLPQQWQSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGSKPPQDAYINGLLEDFDNISVTRSNSLRKESPPTPR 121
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: bri3bp (BRI3 binding protein [Source:Xenbase;Acc:XB-GENE-943691])

HSP 1 Score: 354.755 bits (909), Expect = 3.551e-113
Identity = 166/301 (55.15%), Postives = 222/301 (73.75%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            + E+FR A++ +V+P DPR YL +  KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEM+D EPPYF E PL+AM++IRD  P   +   ++   L+ FLD +L+++  +R  A +LLRHPF +++ P +  I+ L+ +Y  +
Sbjct:  426 SHEQFRAALQLVVSPGDPREYLDDFIKIGEGSTGIV--------CIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRVKDVHQVSSVLRGFLDLMLVREPSQRATAQELLRHPFLKLSGPPS-CIIPLMRQYRHH 717

HSP 2 Score: 52.373 bits (124), Expect = 1.732e-6
Identity = 37/102 (36.27%), Postives = 48/102 (47.06%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLP-----SGQSSNRQSITIVNSNSLHKTSSNNNR 329
            K DIS P  F H  H  F  K   F GLP QW +L+ +      P+VD S IT  +  P K IV   + P     +G   +  +I++  SNSL K S    R
Sbjct:    8 KLDISGPSNFEHRVHTGFDHKEQKFIGLPQQWQSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGSKPPQDAYINGLLEDFDNISVTRSNSLRKESPPTPR 109
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: bri3bp (BRI3 binding protein [Source:Xenbase;Acc:XB-GENE-943691])

HSP 1 Score: 354.755 bits (909), Expect = 4.241e-113
Identity = 166/301 (55.15%), Postives = 222/301 (73.75%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            + E+FR A++ +V+P DPR YL +  KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEM+D EPPYF E PL+AM++IRD  P   +   ++   L+ FLD +L+++  +R  A +LLRHPF +++ P +  I+ L+ +Y  +
Sbjct:  438 SHEQFRAALQLVVSPGDPREYLDDFIKIGEGSTGIV--------CIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRVKDVHQVSSVLRGFLDLMLVREPSQRATAQELLRHPFLKLSGPPS-CIIPLMRQYRHH 729

HSP 2 Score: 51.9878 bits (123), Expect = 2.612e-6
Identity = 36/100 (36.00%), Postives = 47/100 (47.00%), Query Frame = 3 
Query:   51 DISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLP-----SGQSSNRQSITIVNSNSLHKTSSNNNR 329
            DIS P  F H  H  F  K   F GLP QW +L+ +      P+VD S IT  +  P K IV   + P     +G   +  +I++  SNSL K S    R
Sbjct:   22 DISGPSNFEHRVHTGFDHKEQKFIGLPQQWQSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGSKPPQDAYINGLLEDFDNISVTRSNSLRKESPPTPR 121
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Match: pou5f3.2 (POU class 5 homeobox 3, gene 2 [Source:Xenbase;Acc:XB-GENE-919841])

HSP 1 Score: 349.747 bits (896), Expect = 6.533e-113
Identity = 168/309 (54.37%), Postives = 223/309 (72.17%), Query Frame = 3 
Query:  627 SLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNK 1553
            S ++   + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      + + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWV+ME+L+GG LTDIVT  R+  ++I T+C S+L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ++ +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLGIMVIEMVD EPPYF E PL+AMK IRD  P   ++  ++ P L+ FLD LL++D  +R  A++LL+HPF     P   S ++ L + N+
Sbjct:  283 SPQREPQRVSHEQFRAALQMVVDPGDPRTYLDNFIKIGEGSTGIVCIA-----TIKSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVIMEFLEGGALTDIVTHTRMNEEQIATVCVSVLKALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVNKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNAQKVSPLLKGFLDRLLVRDPSQRASANELLKHPFLGKAGPP--SCIVPLMRQNR 581
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Pak4 (p21 (RAC1) activated kinase 4 [Source:MGI Symbol;Acc:MGI:1917834])

HSP 1 Score: 353.214 bits (905), Expect = 3.165e-114
Identity = 168/307 (54.72%), Postives = 221/307 (71.99%), Query Frame = 3 
Query:  627 SLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            S ++   + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C ++L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLG+MVIEMVD EPPYF E PL+AMK IRD  P   ++  +  P L+ FLD LL++D  +R  A++LL+HPF     P   SI+ L+ ++
Sbjct:  293 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA-----TVRSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPA-SIVPLMRQH 590
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Pak4 (p21 (RAC1) activated kinase 4 [Source:MGI Symbol;Acc:MGI:1917834])

HSP 1 Score: 353.214 bits (905), Expect = 3.165e-114
Identity = 168/307 (54.72%), Postives = 221/307 (71.99%), Query Frame = 3 
Query:  627 SLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            S ++   + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C ++L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLG+MVIEMVD EPPYF E PL+AMK IRD  P   ++  +  P L+ FLD LL++D  +R  A++LL+HPF     P   SI+ L+ ++
Sbjct:  293 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA-----TVRSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPA-SIVPLMRQH 590
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Pak7 (p21 (RAC1) activated kinase 7 [Source:MGI Symbol;Acc:MGI:1920334])

HSP 1 Score: 352.058 bits (902), Expect = 2.916e-112
Identity = 165/299 (55.18%), Postives = 218/299 (72.91%), Query Frame = 3 
Query:  660 EEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            E+FR A++ +V+P DPR YL    KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEM+D EPPYF E PL+AM++IRD  P   +   ++   L+ FLD +L+++  +R  A +LL HPF ++  P +  I+ L+ +Y  +
Sbjct:  430 EQFRAALQLVVSPGDPREYLDNFIKIGEGSTGIV--------CIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPS-CIVPLMRQYRHH 719
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Pak7 (p21 (RAC1) activated kinase 7 [Source:MGI Symbol;Acc:MGI:1920334])

HSP 1 Score: 352.058 bits (902), Expect = 2.916e-112
Identity = 165/299 (55.18%), Postives = 218/299 (72.91%), Query Frame = 3 
Query:  660 EEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            E+FR A++ +V+P DPR YL    KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEM+D EPPYF E PL+AM++IRD  P   +   ++   L+ FLD +L+++  +R  A +LL HPF ++  P +  I+ L+ +Y  +
Sbjct:  430 EQFRAALQLVVSPGDPREYLDNFIKIGEGSTGIV--------CIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPS-CIVPLMRQYRHH 719
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Match: Pak6 (p21 (RAC1) activated kinase 6 [Source:MGI Symbol;Acc:MGI:2679420])

HSP 1 Score: 341.273 bits (874), Expect = 1.195e-108
Identity = 158/284 (55.63%), Postives = 210/284 (73.94%), Query Frame = 3 
Query:  645 GQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFF 1496
            G  T E+F+ A++ +V+  DPR  L    KIG+GSTG+V L+              R VA+K M+L  QQRRELLFNEV+ MR+Y H+N+VE + SYLV +ELWV+ME+L GG LTDI++++RL  ++I T+C+++L AL YLH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQIS DVP+R SLVGTPYWMAPEVISR  Y T +DIWSLGIMVIEMVD EPPYF + P++AMK++RD +P   ++  ++ P L+ FLD +L+++ + R  A +LL HPF 
Sbjct:  384 GIVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREK--------HSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFL 659

HSP 2 Score: 61.2326 bits (147), Expect = 2.383e-9
Identity = 39/114 (34.21%), Postives = 60/114 (52.63%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVK--EKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLP-----SGQSSNRQSITIVNSNSLHKTSSNNNRETKKSNQLID 359
            + +IS P+ F+H  H  F  K G F GLPPQW N++    +P    PVVD S+IT  +  P K +V    +P     SG  ++ Q +++++SN+L   S  + R  +    L D
Sbjct:    9 RPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRP---KPVVDPSRITRVQLQPMKTVVRGSSVPTEGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGD 119
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q9VXE5|PAKM_DROME (Serine/threonine-protein kinase PAK mbt OS=Drosophila melanogaster OX=7227 GN=mbt PE=1 SV=2)

HSP 1 Score: 360.533 bits (924), Expect = 1.217e-115
Identity = 166/300 (55.33%), Postives = 220/300 (73.33%), Query Frame = 3 
Query:  636 KSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILML 1535
            K D + T E+FR A++ +V+  DPR  L    KIG+GSTG V ++ +            R VA+KKM+L  QQRRELLFNEV+ MR+Y H NIVET+ S+LV DELWVVMEYL+GG LTDIVT  R++ ++I T+CK  L AL YLH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S ++P+R SLVGTPYWM+PEVISR PY   +DIWSLGIMVIEMVD EPP+F E PL+AM++IRD+ P + ++  ++ P LQ+FLD +L++D  +R  A++LL HPF +   P +  + ++
Sbjct:  341 KQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDK--------STGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLM 632
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|O96013|PAK4_HUMAN (Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1)

HSP 1 Score: 353.984 bits (907), Expect = 1.198e-113
Identity = 168/299 (56.19%), Postives = 218/299 (72.91%), Query Frame = 3 
Query:  648 QYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEK 1544
            + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C ++L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLGIMVIEMVD EPPYF E PL+AMK IRD  P   ++  ++ P L+ FLD LL++D  +R  A++LL+HPF     P   SI+ L+ +
Sbjct:  298 RVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA-----TVRSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA-SIVPLMRQ 587
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q8BTW9|PAK4_MOUSE (Serine/threonine-protein kinase PAK 4 OS=Mus musculus OX=10090 GN=Pak4 PE=1 SV=1)

HSP 1 Score: 353.214 bits (905), Expect = 2.214e-113
Identity = 168/307 (54.72%), Postives = 221/307 (71.99%), Query Frame = 3 
Query:  627 SLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            S ++   + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V + G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C ++L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +VPRR SLVGTPYWMAPE+ISR PY   +DIWSLG+MVIEMVD EPPYF E PL+AMK IRD  P   ++  +  P L+ FLD LL++D  +R  A++LL+HPF     P   SI+ L+ ++
Sbjct:  293 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA-----TVRSSG---KLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPA-SIVPLMRQH 590
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|D4A280|PAK5_RAT (Serine/threonine-protein kinase PAK 5 OS=Rattus norvegicus OX=10116 GN=Pak5 PE=1 SV=1)

HSP 1 Score: 353.214 bits (905), Expect = 7.466e-112
Identity = 179/363 (49.31%), Postives = 243/363 (66.94%), Query Frame = 3 
Query:  480 GNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLKKSDGQ----YTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            G SS   + P  H+     + S+ + S  + + S +     +SS+   PS   S  Q     + E+FR A++ +V+P DPR YL    KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEM+D EPPYF E PL+AM++IRD  P   +   ++   L+ FLD +L+++  +R  A +LL HPF ++  P +  I+ L+ +Y  +
Sbjct:  365 GYSSSSHQYPGYHKASLYHHPSLQTSSQYISTASYLSSLSISSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLDNFIKIGEGSTGIV--------CIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPS-CIVPLMRQYRHH 718
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Match: sp|Q8C015|PAK5_MOUSE (Serine/threonine-protein kinase PAK 5 OS=Mus musculus OX=10090 GN=Pak5 PE=1 SV=1)

HSP 1 Score: 352.058 bits (902), Expect = 2.040e-111
Identity = 165/299 (55.18%), Postives = 218/299 (72.91%), Query Frame = 3 
Query:  660 EEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            E+FR A++ +V+P DPR YL    KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEM+D EPPYF E PL+AM++IRD  P   +   ++   L+ FLD +L+++  +R  A +LL HPF ++  P +  I+ L+ +Y  +
Sbjct:  430 EQFRAALQLVVSPGDPREYLDNFIKIGEGSTGIV--------CIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPS-CIVPLMRQYRHH 719
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A4W5JGB1 (Non-specific serine/threonine protein kinase OS=Hucho hucho OX=62062 PE=4 SV=1)

HSP 1 Score: 374.4 bits (960), Expect = 3.235e-120
Identity = 213/508 (41.93%), Postives = 290/508 (57.09%), Query Frame = 3 
Query:   63 PEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNR-----QSITIVNSNSLHKTSSNNNRETKKSNQLIDKXXXXXXXXXXXXXYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLK---KSDGQ---YTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            P  F H  H  F  +   F GLP QW +L+ +      P+VD S IT  +  P K IV   R P   S N       SI++  SNSL K S     +          ++ +    +  +    SH  +  +    +  R       G             V R         +  L   +  + S      G +P       SD Q    + E+FR A++ +VNP DPR YL+   KIG+GSTG+V         ++++    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEM+D EPPYF E PL+AM++IRD  P   +   ++   ++AFLD +L+++  +R  A +LL+HPF +++ P +  I+ L+  Y
Sbjct:   14 PSNFEHRVHTGFDEREQKFTGLPQQWQSLLADTANRPKPMVDPSYITPIQLAPMKTIVRGNRPPKDTSINGLLEEFDSISVTRSNSLRKESPTGPHQAGSGAPKPPSHHPSHPHPNAPEENGFSHYYSRYSCDLDTSSRDFSVEPYGKDDKGFALDGDWAVGRHYRFP--KQNGHLTHGAYSQPSSPYIPPGAYPPPSWGSSSDAQPSRVSHEQFRAALQLVVNPGDPREYLESFIKIGEGSTGIV--------CIASEKHSGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCVSVLRALSYLHTQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRLKESHKVSSVMRAFLDLMLVREPSQRATAQELLQHPFLKLSGPPS-CIVPLMRHY 510
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BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A0L8GFF9 (Non-specific serine/threonine protein kinase OS=Octopus bimaculoides OX=37653 GN=OCBIM_22034255mg PE=4 SV=1)

HSP 1 Score: 373.629 bits (958), Expect = 1.806e-119
Identity = 223/531 (42.00%), Postives = 312/531 (58.76%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRD-PVVDKSKITSSEAVPFKQIV--GSYRLPSGQSSNRQSITIVNSNSLHKTSSNNNRETKKSNQLIDKXXXXXXXXXXXXXYDSSHLKN------------NQNKQTISMERVLQKRITGNSSVQIRTPS---QHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSG-----------NFPS--------LKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQIT-QPST 1517
            K +IS P  F H  H  F  + G + GLP QW  ++   PG R  P+VD + IT ++   +K IV   S    +G +++ +SIT+  SNSL K S  + R  +        +       + +    S+HL +            +++ +T+  E V QK    + +    + S    HR   + +       ++    +  E    N  +G           NFP+        + K  G+   ++FR  ++ +V+P DPR  L    KIG+GSTG+V        I +N+    R VA+KKM+L  QQRRELLFNEV+ MR+Y H NIV+ + SYLV DELWVVMEYL+GG LTDIVT  +++  +I T+C++ L +L YLH HGVIHRDIKSD+ILL+R GK+KLSDFGFCAQ+S ++P+R SLVGTPYWMAPEVISR PY   +DIWSLGIMVIEMVD EPP+F E PL+AM++IRD+ P   R+  ++ P LQAF++ +L++D   R  A +LL+HPF Q+  QPS 
Sbjct:    8 KPEISNPLNFEHRVHTGFDQEQGRYIGLPSQWQGIIG--PGERRRPIVDPAHITPTDMGNYKTIVRGNSSSSINGYAADNKSITVARSNSLRKESPPSLRHKRYVPDSYYASVPEDEPVNYNNRPHSTHLNHSYMRDHMNGPYQDRDFKTLPHEPVHQKNYIDSQNRPRYSDSGHPDHRFNDERSREGPPPYSVGPGHNREEYRPPNPMNGTLMVPVLPKHNNFPAPLSNVNRVIPKHHGRMDYDKFRATLQTVVSPGDPRDELDYFIKIGEGSTGIVC-------IATNRSTGYR-VAVKKMDLGKQQRRELLFNEVVIMRDYHHANIVDMYESYLVGDELWVVMEYLEGGALTDIVTHNKMDEVQIATVCRACLLSLAYLHSHGVIHRDIKSDSILLARDGKVKLSDFGFCAQVSPELPKRKSLVGTPYWMAPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMPPPRIRNDTKVSPRLQAFIEKMLVRDPSARATAFELLQHPFIQLAEQPSC 528
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A5N4AP08 (Uncharacterized protein OS=Photinus pyralis OX=7054 GN=PPYR_06940 PE=4 SV=1)

HSP 1 Score: 372.859 bits (956), Expect = 5.448e-119
Identity = 229/565 (40.53%), Postives = 309/565 (54.69%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKE----KPGSRD-PVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNR-----------------QSITIVNSNSLHKTSSNNNRETKKSNQLIDKXXXXXXXXXXXXXYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRT--------------PSQHRVLRKSNLSIHSDSALLRSKSVIELS-----DQNSSSGNF----------PSLKKSDGQY-----TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSE--NTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFF-QITQPSTRSILMLLEKYNKY 1556
            K  IS P  F H  H  F  + G + GLP QW ++V      K  +R  P+VD S+IT +E +  K IV   R    +  NR                 ++  +  SNSL ++SS         N  +  +                 +   Q ++    ER L      NS +   T              P+        N   H+ S     ++V +L      DQN +  N           PS+  +  Q+     T E+FR A++ +V+P+DPR  L++  KIG+GSTG V ++   NTG          R VA+KKM+L  QQRRELLFNEV+ MR+Y H NIVE F SYLV DELWVVME+L+GG LTDIVT  R++ ++I T+CK  L AL YLH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S ++P+R SLVGTPYWM+PEVISR PY   +DIWSLGIMVIEMVD EPP+F E PL+AM++IR++ P   ++  ++ P LQ FL+ +L++D  +R  ASDLL HPF  Q   P+    LM   ++  Y
Sbjct:    8 KPQISPPTNFEHRVHTGFDKREGRYVGLPLQWASIVGNNQILKSTNRPLPLVDPSEITPTEILDLKTIV---RGEHSKVENRILPQQTKPPVSNGIILPKTSNVARSNSL-RSSSPPRLRRDHHNANVPPSVPEEQILQYPSLRREPCVSKPQVREESPAERSLSNHEGSNSHLNGNTQEPYVGYRDHPQVSPANSVAAPPPNYVPHTQSTSSSHQNVAQLGFPTRPDQNQNIKNGTQVLPHPTIPPSVSTASKQHHEQRLTHEQFRAALQMVVSPKDPRESLEQFMKIGEGSTGTVCIARDRNTG----------RQVAVKKMDLRKQQRRELLFNEVVIMRDYHHANIVEMFDSYLVNDELWVVMEFLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAPDGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIREMPPPKFKNSHKVSPRLQGFLERMLVRDPTQRATASDLLHHPFLRQAGPPALLVPLMRGARHTNY 558
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: A0A1Y1K9C5 (Non-specific serine/threonine protein kinase OS=Photinus pyralis OX=7054 PE=4 SV=1)

HSP 1 Score: 371.703 bits (953), Expect = 1.799e-118
Identity = 228/565 (40.35%), Postives = 310/565 (54.87%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKE----KPGSRD-PVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNR-----------------QSITIVNSNSLHKTSSNNNRETKKSNQLIDKXXXXXXXXXXXXXYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRT--------------PSQHRVLRKSNLSIHSDSALLRSKSVIELS-----DQNSSSGNF----------PSLKKSDGQY-----TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSE--NTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFF-QITQPSTRSILMLLEKYNKY 1556
            K  IS P  F H  H  F  + G + GLP QW ++V      K  +R  P+VD S+IT +E +  K IV   R    +  NR                 ++  +  SNSL ++SS         N  +  +                 +   Q ++    ER L  +   NS +   T              P+        N   H+ S     ++V +L      DQN +  N           PS+  +  Q+     T E+FR A++ +V+P+DPR  L++  KIG+GSTG V ++   NTG          R VA+KKM+L  QQRRELLFNEV+ MR+Y H NIVE F SYLV DELWVVME+L+GG LTDIVT  R++ ++I T+CK  L AL YLH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S ++P+R SLVGTPYWM+PEVISR PY   +DIWSLGIMVIEMVD EPP+F E PL+AM++IR++ P   ++  ++ P LQ FL+ +L++D  +R  AS+LL HPF  Q   P+    LM   ++  Y
Sbjct:    8 KPQISPPTNFEHRVHTGFDKREGRYVGLPLQWASIVGNNQILKSTNRPLPLVDPSEITPTEILDLKTIV---RGEHSKVENRILPQQTKPPVSNGIILPKTSNVARSNSL-RSSSPPRLRRDHHNANVPPSVPEEQILQYPSLRREPCVSKPQVREESPAERSLSNQEGSNSHLNGNTQEPYVGYRDHPQVSPANSVAAPPPNYVPHTQSTSSSHQNVAQLGFPTRPDQNQNIKNGTQVLPHPTIPPSVSTASKQHHEQRLTHEQFRAALQMVVSPKDPRESLEQFMKIGEGSTGTVCIARDRNTG----------RQVAVKKMDLRKQQRRELLFNEVVIMRDYHHANIVEMFDSYLVNDELWVVMEFLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAPDGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIREMPPPKFKNSHKVSPRLQGFLERMLVRDPTQRATASELLHHPFLRQAGPPALLVPLMRGARHTNY 558
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Match: H2Y4H8 (Non-specific serine/threonine protein kinase OS=Ciona savignyi OX=51511 PE=4 SV=1)

HSP 1 Score: 369.007 bits (946), Expect = 1.876e-118
Identity = 221/507 (43.59%), Postives = 289/507 (57.00%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEFKN--GHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNRQSITIVNSNSLHKTS---------------SNNNRETKKSNQLIDKXXXXXXXXXXXXXYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLKKSDGQ-YTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQP 1511
            K DIS P  F H  H  F    G F GLP QW +++ E      P VD   IT    VP            G  SN  +I++  SNSL K S               ++  R T   N  I  +  +  +  +  +  + H  N++N +T         RI  N  +    P+   VL      I    A+    SV   + Q +   N       D Q  T++EFR A++ +V P DPR  L+   KIG+GSTGVV ++   G           +VA+KKMN+  QQRRELLFNEV+ MR+Y H NIV+ + S+LV DELWVVMEY++GG LTD+VTR RL   +I T+C S+LNAL YLH  GVIHRDIKSD+ILL++   +KLSDFGFCAQISSDVP+R SLVGTPYWMAPEV+SR PY   +DIWSLGIM++EMVD EPPYF E PL AM++IRD+ P   +H  ++ P   + L  +L++D   R  AS+LL+HPF + + P
Sbjct:    5 KPDISGPSNFEHRVHTGFNEDEGKFIGLPIQWQSIIPEVKNRPKPFVDARHIT---PVP------------GVLSNLSAISVTRSNSLRKESPPESQKDTDPVNIMFNSQMRSTDIPNPYIPGSKPHPHTTISPTSKHNDHHSNDRNYETTLDLEHKCCRINLNLQLNSIHPTITMVL-----IIEWKEAIGPGVSVAPPAAQKALGTNH------DSQTITNDEFRAALQMVVCPGDPRESLENFVKIGEGSTGVVCIATQRGT--------GHHVAVKKMNVRRQQRRELLFNEVVIMRDYHHENIVDMYSSFLVGDELWVVMEYMEGGALTDLVTRHRLNEPQIATVCVSVLNALAYLHSQGVIHRDIKSDSILLTKDLTVKLSDFGFCAQISSDVPKRKSLVGTPYWMAPEVVSRSPYGPEVDIWSLGIMIMEMVDKEPPYFDEAPLHAMRRIRDMPPPKLKHPHKVNPPPHSHL--ILVRDPSTRSTASELLQHPFLRKSSP 475
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: pak7 (p21 (RAC1) activated kinase 5 [Source:NCBI gene;Acc:103023523])

HSP 1 Score: 356.295 bits (913), Expect = 1.473e-113
Identity = 168/298 (56.38%), Postives = 220/298 (73.83%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            + E+FR A++ +VNP DPR YL    KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEMVD EPPYF E PL+AM++IRD  P   +   ++   L+AFLD +L+++  +R  A +LL+HPF +++ P +  I+ L+  Y
Sbjct:  468 SHEQFRAALQLVVNPGDPREYLDNFLKIGEGSTGIV--------CIATEKHSGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHTQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNLPPRLKESHKVSSVLRAFLDLMLVREPSQRATAQELLQHPFLKLSGPPS-CIVPLMRHY 756
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: pak7 (p21 (RAC1) activated kinase 5 [Source:NCBI gene;Acc:103023523])

HSP 1 Score: 355.525 bits (911), Expect = 5.342e-113
Identity = 168/298 (56.38%), Postives = 220/298 (73.83%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            + E+FR A++ +VNP DPR YL    KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEMVD EPPYF E PL+AM++IRD  P   +   ++   L+AFLD +L+++  +R  A +LL+HPF +++ P +  I+ L+  Y
Sbjct:  493 SHEQFRAALQLVVNPGDPREYLDNFLKIGEGSTGIV--------CIATEKHSGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHTQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNLPPRLKESHKVSSVLRAFLDLMLVREPSQRATAQELLQHPFLKLSGPPS-CIVPLMRHY 781
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: pak7 (p21 (RAC1) activated kinase 5 [Source:NCBI gene;Acc:103023523])

HSP 1 Score: 355.14 bits (910), Expect = 6.838e-113
Identity = 168/298 (56.38%), Postives = 220/298 (73.83%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            + E+FR A++ +VNP DPR YL    KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEMVD EPPYF E PL+AM++IRD  P   +   ++   L+AFLD +L+++  +R  A +LL+HPF +++ P +  I+ L+  Y
Sbjct:  494 SHEQFRAALQLVVNPGDPREYLDNFLKIGEGSTGIV--------CIATEKHSGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHTQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNLPPRLKESHKVSSVLRAFLDLMLVREPSQRATAQELLQHPFLKLSGPPS-CIVPLMRHY 782

HSP 2 Score: 55.0694 bits (131), Expect = 1.749e-7
Identity = 38/107 (35.51%), Postives = 48/107 (44.86%), Query Frame = 3 
Query:   51 DISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNR-----QSITIVNSNSLHKTSSNNNRETKKSNQ 350
            +IS P  F H  H  F  +   F GLP QW +L+ +      P+VD S IT  +  P K IV   R P   S N       SI++  SNSL K S     +   S Q
Sbjct:   60 EISAPSNFEHRVHTGFDPREQKFTGLPQQWQSLLADTANRPKPMVDPSYITPIQLAPMKTIVRGNRPPKDASINGLLEEFDSISVTRSNSLRKESPPGAHQAGSSKQ 166
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: pak7 (p21 (RAC1) activated kinase 5 [Source:NCBI gene;Acc:103023523])

HSP 1 Score: 355.525 bits (911), Expect = 7.740e-113
Identity = 168/298 (56.38%), Postives = 220/298 (73.83%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            + E+FR A++ +VNP DPR YL    KIG+GSTG+V         ++ +    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEMVD EPPYF E PL+AM++IRD  P   +   ++   L+AFLD +L+++  +R  A +LL+HPF +++ P +  I+ L+  Y
Sbjct:  509 SHEQFRAALQLVVNPGDPREYLDNFLKIGEGSTGIV--------CIATEKHSGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHTQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNLPPRLKESHKVSSVLRAFLDLMLVREPSQRATAQELLQHPFLKLSGPPS-CIVPLMRHY 797
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Match: pak6b (serine/threonine-protein kinase PAK 6-like [Source:NCBI gene;Acc:103030407])

HSP 1 Score: 349.362 bits (895), Expect = 6.643e-112
Identity = 164/302 (54.30%), Postives = 220/302 (72.85%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKYL 1559
            T  +F+ A++ +V+  DPR YL+   KIG+GSTGVV         ++ +    + VA+K M+L  QQRRELLFNEV+ MR+Y H N+VE + S LV++ELWV+MEYL GG LT+IV+  RL  ++I T+C+++L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQIS D+P+R SLVGTPYWMAPEVIS+ PY T +D+WSLGIMV+EMVD EPPYF + P+ AMK++RD    S R+  ++ P L+ FLDS+L +D  +R  ASDLL+HPF  +   + R ++ L+E Y K +
Sbjct:  375 THAQFKAALQMVVDKGDPRMYLENFVKIGEGSTGVV--------CIAREKHSGKQVAVKMMDLRKQQRRELLFNEVVIMRDYRHKNVVEMYKSALVEEELWVIMEYLQGGALTNIVSETRLTEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRIKLSDFGFCAQISKDIPKRKSLVGTPYWMAPEVISKTPYGTEVDVWSLGIMVVEMVDGEPPYFSDTPVAAMKRLRDEPAPSVRNSSKISPVLKDFLDSMLTRDPLQRSSASDLLKHPFL-LQSGAPRCLVPLVEHYRKRM 667
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69])

HSP 1 Score: 350.517 bits (898), Expect = 8.061e-113
Identity = 168/298 (56.38%), Postives = 215/298 (72.15%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            + E+FR A++++V+P DP  YL+   KIG+GSTGVV L+ +            R VA+KKM+L  QQRRELLFNEV+ MR Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +V RR SLVGTPYWMAPEVISR PY   +D+WSLGIMVIEMVD EPPYF E PL+AM++IRD  P   ++  +  P L+ FLD +L++D   R  A +LL+HPF Q   P    I+ L+ ++
Sbjct:  398 SHEQFRAALQQVVDPGDPSEYLENFIKIGEGSTGVVCLAVDRRS--------GRQVAVKKMHLRKQQRRELLFNEVVIMREYHHENVVDMYNSYLVADELWVVMEFLEGGALTDIVTHTRMNEEQIATVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRIKLSDFGFCAQVSKEVTRRKSLVGTPYWMAPEVISRLPYGPEVDVWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNVPPKMKNIQKASPLLRGFLDQMLVRDPALRATALELLQHPFLQNAGPPA-CIVPLMRQH 686

HSP 2 Score: 56.9954 bits (136), Expect = 9.223e-9
Identity = 37/101 (36.63%), Postives = 50/101 (49.50%), Query Frame = 3 
Query:   51 DISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLPSGQS------SNRQSITIVNSNSLHKTSSNNNR 329
            +IS P  F H +H +F  +   F GLPPQW +L+ +      PVVD S IT  +  P K IV     P  +S      S  ++I++  SNSL K S    R
Sbjct:   10 EISAPSNFEHRFHTDFDKEERKFTGLPPQWQSLLADTANRPKPVVDPSYITPIQLAPMKPIVRGSSKPRAESAINGLLSEFRNISVSRSNSLRKESPPYAR 110
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69])

HSP 1 Score: 187.963 bits (476), Expect = 4.296e-53
Identity = 89/164 (54.27%), Postives = 119/164 (72.56%), Query Frame = 3 
Query:  660 EEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSEN--TGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIK 1145
            E+FR A++++V+P DP ++L    KIG+GSTGVV L+E+  TG          + VA+K+M+L  QQRRELLFNEV+ MR Y H N+V  + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C S+L AL YLH  GVIHRDIKSD+ILL+  G+++
Sbjct:  358 EQFRAALQQVVDPGDPSQFLGSFIKIGEGSTGVVCLAEDKRTG----------KQVAVKRMHLRKQQRRELLFNEVVIMREYHHENVVNMYNSYLVDDELWVVMEFLEGGALTDIVTHTRMNEEQISAVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRVR 511

HSP 2 Score: 52.7582 bits (125), Expect = 1.412e-7
Identity = 31/68 (45.59%), Postives = 36/68 (52.94%), Query Frame = 3 
Query:   54 ISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIV-GSYRLP 248
            IS P  F H  H  F    G F GLPPQW +L+ +      PVVD S IT  +  P K IV GS +LP
Sbjct:   12 ISAPCNFEHRVHTGFDLAEGRFTGLPPQWQSLLADTANRPKPVVDASYITPVDLAPMKIIVRGSKKLP 79
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69])

HSP 1 Score: 187.193 bits (474), Expect = 9.902e-53
Identity = 89/164 (54.27%), Postives = 119/164 (72.56%), Query Frame = 3 
Query:  660 EEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSEN--TGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIK 1145
            E+FR A++++V+P DP ++L    KIG+GSTGVV L+E+  TG          + VA+K+M+L  QQRRELLFNEV+ MR Y H N+V  + SYLV DELWVVME+L+GG LTDIVT  R+  ++I  +C S+L AL YLH  GVIHRDIKSD+ILL+  G+++
Sbjct:  378 EQFRAALQQVVDPGDPSQFLGSFIKIGEGSTGVVCLAEDKRTG----------KQVAVKRMHLRKQQRRELLFNEVVIMREYHHENVVNMYNSYLVDDELWVVMEFLEGGALTDIVTHTRMNEEQISAVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRVR 531

HSP 2 Score: 52.7582 bits (125), Expect = 1.690e-7
Identity = 31/71 (43.66%), Postives = 37/71 (52.11%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIV-GSYRLP 248
            +  IS P  F H  H  F    G F GLPPQW +L+ +      PVVD S IT  +  P K IV GS +LP
Sbjct:    9 RPQISAPCNFEHRVHTGFDLAEGRFTGLPPQWQSLLADTANRPKPVVDASYITPVDLAPMKIIVRGSKKLP 79
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92])

HSP 1 Score: 184.111 bits (466), Expect = 2.101e-52
Identity = 108/292 (36.99%), Postives = 156/292 (53.42%), Query Frame = 3 
Query:  702 DPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNR---YVAIKKMNLFNQQRRELLFN-EVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDA--ILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKI-RDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            DP     + ++IG+GS G VF           KG  NR    VAIK ++L   +        E+  +       +   FGSYL   +LW++MEYL GG+  D++    LE  +I TI + IL  LDYLH    IHRDIK  A  +LLS +G +KL+DFG   Q++    +R + VGTP+WMAPEVI +  Y+   DIWSLGI  IE+   EPP     P+  +  I ++  P    +Y +     + F+DS L KD + RP A +LL+H F Q +   T  +  L+++Y ++
Sbjct:   21 DPEELFTKQERIGKGSFGEVF-----------KGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALDLIKPGPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPTLEGNYSKA---FKEFVDSCLNKDPQFRPTAKELLKHKFIQRSAKKTSYLTELIDRYKRW 298
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865])

HSP 1 Score: 174.866 bits (442), Expect = 8.317e-47
Identity = 104/290 (35.86%), Postives = 156/290 (53.79%), Query Frame = 3 
Query:  708 RRYLKE----IKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIR-LEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVIS---RQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKI--RDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRS-ILMLLEK 1544
            RR L+E     +++G G+ G V  + N        G+    VAIK + L       ++  E++ M+   H NIV  +GSYL  D+LW+ ME+  GG+L DI      L  ++I  + +  L  L YLH  G +HRDIK   ILL+  G +KL+DFG  AQI++ + +R S +GTPYWMAPEV +   +  YN   D+W++GI  IE+ + +PP F   P+ A+  +      P   R   +  P    F+   L K+ ++RP A  +L H + Q  QP +R+  L LLE+
Sbjct:    7 RRTLQEDFELAERLGSGTYGDVHKARNV-----QTGEL---VAIKIIKLEPGDDFSVIQQEIVMMKECKHTNIVAYYGSYLRHDKLWICMEHCGGGSLQDIYHVTGPLTERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKMLTHSYVQ--QPLSRAQALELLER 286
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 257.684 bits (657), Expect = 4.613e-76
Identity = 124/273 (45.42%), Postives = 173/273 (63.37%), Query Frame = 3 
Query:  678 IKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFF 1496
            + EI +  DP      + KIGQG++G V+ +   G  VS        VAIK+MNL  Q ++EL+ NE+L M+   H NIV    SY++K +LWV+MEY++GG+LTD+VT   L   +I  +C+  L+ L++LH  GV+HRDIKSD ILLS +G IKL+DFGFCAQI+    +R ++VGTPYWMAPEV+SR+ Y   +DIWSLGIM+IEM++ EPPY  E PL A+  I        +  + +   L+ FLD  L  +   R  A++LL   + 
Sbjct:  607 LNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVS--------VAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYI 871
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242])

HSP 1 Score: 229.565 bits (584), Expect = 2.287e-66
Identity = 119/301 (39.53%), Postives = 177/301 (58.80%), Query Frame = 3 
Query:  663 EFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTG--------GIVSNKGD---FNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYL-VKDELWVVMEYLDGGTLTDIV--------TRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQIT 1505
            E    +K++    DP +  K I+K GQG++G V+L+E T          +++N  D       VAIK+M L  Q R+EL+ NE+L M++  H NIV    +YL   D+LWVVME+++GG+LTDI+        +   L   +I  I +     L +LH   +IHRDIKSD +LL  + ++K++DFGFCA+++    +R ++VGTPYWMAPEV+ ++ Y+  ID+WSLGIM IEM++ EPPY  E PL+A+  I        +H + +  E++ FL   L  D R R    +LL H FF + 
Sbjct:  528 EIMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFNMA 828
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473])

HSP 1 Score: 215.312 bits (547), Expect = 2.995e-62
Identity = 153/527 (29.03%), Postives = 261/527 (49.53%), Query Frame = 3 
Query:   54 ISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVG------------SYRLPSGQSSNRQSITIVNSNSLHKTSSNNNRETKKSNQL-IDKXXXXXXXXXXXXXYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRTPSQHRVLRKSNLSIHSDSALLR----SKSVIELSDQNSSSG----NFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDF---------NRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDE-LWVVMEYLDGGTLTDIVTRIR----------LEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQIT 1505
            +S P  F H  HV F  K G+F G+P  W  L++    + D     SK        ++   G            S  L   +S  R  I    +NS+ ++ S   R+ K  + L + ++        +  +Y  +++++N+ ++   +   + K  T +S  +     + +V++ S+L  H +++  R    + S     + +S +     +   LK +D      E    +K +    +PR Y + ++K GQG++G V+LS+       N   F            VAIK++ L  Q +++L+ NE+L M +    NIV    +Y++ DE LWV+MEY++GG LTDI+  +           L   ++  I K     L +LH   +IHRDIKSD ILL+ +G +K++DFGFC +++    +R ++VGTPYWMAPE+++++ Y+  +D+WSLGIM+IEM++ EPPY  E PL+A+  I +      RH + +  + + FLD+ L  +   R     LL   F  + 
Sbjct:  123 VSSPTNFTHKVHVGFDPKVGNFVGVPDSWAKLLQTSEITYDDWNRNSKAVIKALQFYEDYNGLDTMQFNDHLNTSLDLKPLKSPTRYIIN-KRTNSIKRSVSRTLRKGKTDSILPVYQSELKPFPRPSDDDYKFTNIEDNKVREEGRVH--VSKESTADSQTKQLGKKEQKVIQ-SHLRRHDNNSTFRPHRLAPSAPATKNHDSKTKWHKEDLLELKNNDDS---NEIIMKMKTVAIDVNPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSMA 642
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 160.999 bits (406), Expect = 3.504e-42
Identity = 101/287 (35.19%), Postives = 151/287 (52.61%), Query Frame = 3 
Query:  717 LKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQ------RRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQP-YNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSP--MSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILM-LLEKY 1547
             K  + IG+G  GVV+   N            R  AIK +NL +        +RE+ F  + +++  S  NI   +GSYL    LW++ME+  GG+L  ++   +++ + I  I + +L AL  +H   VIHRDIK+  +L++ +G +KL DFG  AQ++    RR ++ GTPYWMAPEVI     Y+T +DIWSLGI   E+    PPY     L AM+ I    P  +  R Y      L+ F+   L +D + R  A DLL+  F +  + +  SIL  L+ +Y
Sbjct:   23 FKRTEVIGRGKFGVVYKGYNV--------KTGRVYAIKVLNLDSDSDEVEDVQREIQF--LASLKQIS--NITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYST---SLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKELISRY 294
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124])

HSP 1 Score: 130.954 bits (328), Expect = 5.946e-34
Identity = 75/263 (28.52%), Postives = 141/263 (53.61%), Query Frame = 3 
Query:  726 IKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKS-ILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRR-----PKASDLLRHPFF 1496
            ++ +G GS G V L  +      + G +     +KK  +   ++ E   +E   ++   H  ++  +G++     +++VM+Y++GG L  ++ + +  P  +     + ++ AL+YLH H +I+RD+K + ILL R G IK++DFGF  ++ +      +L GTP ++APEVI+ +PYN S+D WSLG+++ EM+    P++   P++  +KI     +   ++    P++   L  L+  D  RR       + D+  HP+F
Sbjct:   73 MRTLGTGSFGRVHLVRSV-----HNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVT---WTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGKVVYPPYFH---PDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWF 324
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO45846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL1])

HSP 1 Score: 344.739 bits (883), Expect = 1.584e-115
Identity = 167/289 (57.79%), Postives = 212/289 (73.36%), Query Frame = 3 
Query:  639 SDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSEN--TGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQ 1499
            SD   T E+FR  ++ +V        L    KIG+GSTG+V L+ +  TG          R VA+KKM+L  QQRRELLFNEV+ MR+Y H NIVE +GS+LV DELWVVME+L+GGTLTDIVT   L  +++  +C+++L AL +LH  GVIHRDIKSD+ILL+  G +KLSDFGFCAQ++ D+PRR SLVGTPYWMAPEVISR+PY T +DIWSLGIMV+EMVD EPPYF E PL+AM+K+RDL P +SR+  ++ P LQ+FLD+ LI+D   R  A +LL HPF +
Sbjct:    3 SDTPVTHEQFRRHLEVVVQSTRQPENLGNFMKIGEGSTGIVCLATDKRTG----------RQVAVKKMDLKKQQRRELLFNEVVIMRDYPHPNIVEMYGSHLVGDELWVVMEFLEGGTLTDIVTHTNLSEEQVACVCRAVLKALTFLHSQGVIHRDIKSDSILLTSNGTVKLSDFGFCAQVTEDMPRRKSLVGTPYWMAPEVISRKPYGTEVDIWSLGIMVLEMVDGEPPYFNEPPLQAMRKLRDLEPPTSRNPIQISPRLQSFLDNALIRDPLYRATAFELLNHPFIR 281
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO33667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRJ0])

HSP 1 Score: 277.33 bits (708), Expect = 1.006e-86
Identity = 140/335 (41.79%), Postives = 202/335 (60.30%), Query Frame = 3 
Query:  534 SNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLL 1538
            S+ S++ D+      S  E +    S G   +  K   + +DEE    ++ IV+  DP++   + +KIGQG++G V+ +                VAIK+MNL  Q ++EL+ NE+L MR   H NIV    SYLV +ELWVVMEYL GG+LTD+VT   ++  +I  +C+  L AL++LH +GVIHRDIKSD ILL   G++KL+DFGFCA I+ +  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM IEMV+ EPPY  E PL A+  I         H +++ P  + FL   L  D  +R  A +LL+HPF +  +P    + ++L
Sbjct:  165 SSNSVNDDAQPPAIPSRPEHTKSKPSHGQVQARDKRKKKMSDEEILARLRTIVSIGDPKKKYTKFEKIGQGASGTVYTAIEVAT--------GHEVAIKQMNLSQQPKKELIINEILVMRENKHPNIVNYVDSYLVGEELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNGVIHRDIKSDNILLGMDGQVKLTDFGFCATITPEQNKRSTMVGTPYWMAPEVVTRKQYGPRVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELAHPEKLSPVFKDFLAQSLEMDVEKRSSARELLQHPFLKQAKPLASLVPLIL 491
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO49047 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHW1])

HSP 1 Score: 172.94 bits (437), Expect = 2.211e-49
Identity = 102/292 (34.93%), Postives = 162/292 (55.48%), Query Frame = 3 
Query:  702 DPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDI--VTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQ---PYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKI--RDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILM-LLEKYNK 1553
            +P +    I+K+G G+ G VF +      V   GD     A+K + +      EL+  E+  M+   H NI+   G+Y+ +D+LW+ MEY  GG++ D+  VT    E Q I  +    L  L YLH   ++HRDIK   ILL+  G++KL+DFG  A+I+  + +R S +GTPYWMAPE+ + +    Y+   DIW++GI  IEM + +PP F   P+ A+  I  +   P + +  D+   E+  F+   LIK+ ++RP A  +L HPF    +  T+++L  LL++Y +
Sbjct:   13 NPDKVFDLIEKVGGGTYGDVFKAR-----VIATGDL---AAVKVVKVEPGDDFELIQQEIAMMQQCRHNNIINYIGAYMRRDKLWIGMEYCGGGSIQDVYCVTGPCSETQ-ISFVTVETLKGLAYLHEKSLMHRDIKGANILLTTNGEVKLADFGISARITETMKKRKSFIGTPYWMAPEMAAVERTGGYDLKCDIWAVGITAIEMAELQPPMFDLHPMRALYIIGKKSFIPPTLKEKDKWSNEMHHFIKVALIKNPKKRPSADKMLTHPF--CCRHLTKAVLQDLLDRYRR 293
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9])

HSP 1 Score: 173.326 bits (438), Expect = 2.470e-49
Identity = 102/311 (32.80%), Postives = 164/311 (52.73%), Query Frame = 3 
Query:  705 PRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIR---LEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQ------ITQPSTRSILMLLEKYNKYLDNTGY*FIFIFPKTCAH 1610
            P      ++K+G+GS G VF + +         +  + VAIK++ +    +   +  E+  M+      +V+ +GSY    +LW+VMEY   G+++D++ +IR   L  +EI  + K  L  L+YLH    IHRDIK+  ILL+ +G  KL+DFG   Q++  + +R +++GTP+WMAPEVI    Y+   DIWSLGI  +EM + +PPY    P+ A+  I    P + R   +   + + F+   L+K+   R  A++LL+H F Q      I     +  L ++E+ N   D   Y  I I  K+  H
Sbjct:   20 PEEVFDVLEKLGEGSYGSVFKAMHK--------ESGQVVAIKQVPVDTDLQE--IIKEISMMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDLM-KIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEVGYDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSFIQGAKQISILSSMIQEALTIMEEENARDDEIAY-LIQIICKSSIH 318
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4])

HSP 1 Score: 174.481 bits (441), Expect = 4.932e-49
Identity = 101/294 (34.35%), Postives = 158/294 (53.74%), Query Frame = 3 
Query:  702 DPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFN-EVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPEL--------QAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKY 1556
            DP +   ++++IG+GS G VF        + N+   N  VAIK ++L   +        E+  +     + + +  GSYL   +LW++MEYL GG+  D++    +E   I TI + +L  LDYLH    +HRDIK+  +L+S  G +KL+DFG   Q++  + +R + VGTP+WMAPEVI +  Y++  DIWSLGI  IE+   EPP     P+    ++  L P ++      PPEL        + F+   L KD   RP A +LL+H F + T      ++ L+E++ K+
Sbjct:    6 DPEKLFSKLERIGKGSFGEVFKG------IDNRT--NEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSLYVTKYHGSYLKGTKLWIIMEYLGGGSALDLMKAGNIEEFYIATILREVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQLTDTLNKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPNSDLHPM----RVLFLIPKNN------PPELTGNFSKAFKEFVSLCLNKDPNDRPTAKELLKHRFIK-TAKKNAYLVELIERHKKW 280
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: pak4 (p21 (RAC1) activated kinase 4 [Source:NCBI gene;Acc:101162543])

HSP 1 Score: 348.591 bits (893), Expect = 7.421e-113
Identity = 169/298 (56.71%), Postives = 218/298 (73.15%), Query Frame = 3 
Query:  660 EEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNK 1553
            E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V   G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +V RR SLVGTPYWMAPE+ISR PY   +DIWSLGIMVIEMVD EPPYF E PL+AMK IRD SP   ++  ++ P L+ FLD +L+++  +R  AS+LL+HPF   + P   S ++ L + N+
Sbjct:  279 EQFRAALQMVVDPGDPRTYLDHYIKIGEGSTGIVCIA-----TVKTTG---KLVAVKKMDLKKQQRRELLFNEVVIMRDYHHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCVSVLKALSVLHSQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVQRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNSPPKLKNLHKVSPLLKGFLDRMLVREPAQRATASELLKHPFLAKSGPP--SCIVPLMRQNR 566
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: pak7 (p21 (RAC1) activated kinase 5 [Source:NCBI gene;Acc:101159788])

HSP 1 Score: 353.984 bits (907), Expect = 7.719e-113
Identity = 167/298 (56.04%), Postives = 221/298 (74.16%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            + E+FR A++ +VNP DPR YL    KIG+GSTG+V         ++++    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEMVD EPPYF E PL+AM++IRD  P   +   ++   L++FLD +L+++  +R  A +LL+HPF +++ P +  I+ L+  Y
Sbjct:  451 SHEQFRAALQLVVNPGDPREYLDNFIKIGEGSTGIV--------CIASEKHSGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHTQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNLPPRLKESHKVSSVLRSFLDMMLVREPSQRATAQELLQHPFLKMSGPPS-CIVPLMRHY 739

HSP 2 Score: 50.8322 bits (120), Expect = 3.641e-6
Identity = 35/95 (36.84%), Postives = 45/95 (47.37%), Query Frame = 3 
Query:   51 DISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNR-----QSITIVNSNSLHKTS 314
            +IS P  F H  H  F  +   F GLP QW +L+ +      P+VD S IT  +  P K IV   R P   S N       +I++  SNSL K S
Sbjct:   10 EISAPSNFEHRVHTGFDPREQKFTGLPQQWQSLLADTANRPKPMVDPSYITPIQLAPMKTIVRGNRPPKDASINGLLEEFDNISVTRSNSLRKES 104
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: pak7 (p21 (RAC1) activated kinase 5 [Source:NCBI gene;Acc:101159788])

HSP 1 Score: 353.984 bits (907), Expect = 9.956e-113
Identity = 167/298 (56.04%), Postives = 221/298 (74.16%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKY 1547
            + E+FR A++ +VNP DPR YL    KIG+GSTG+V         ++++    + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+V+ + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL YLH  GVIHRDIKSD+ILL+  G+IKLSDFGFCAQ+S +VP+R SLVGTPYWMAPEVISR PY T +DIWSLGIMVIEMVD EPPYF E PL+AM++IRD  P   +   ++   L++FLD +L+++  +R  A +LL+HPF +++ P +  I+ L+  Y
Sbjct:  466 SHEQFRAALQLVVNPGDPREYLDNFIKIGEGSTGIV--------CIASEKHSGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHTQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNLPPRLKESHKVSSVLRSFLDMMLVREPSQRATAQELLQHPFLKMSGPPS-CIVPLMRHY 754
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: pak4 (p21 (RAC1) activated kinase 4 [Source:NCBI gene;Acc:101162543])

HSP 1 Score: 348.977 bits (894), Expect = 1.198e-111
Identity = 170/309 (55.02%), Postives = 223/309 (72.17%), Query Frame = 3 
Query:  627 SLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNK 1553
            S ++   + + E+FR A++ +V+P DPR YL    KIG+GSTG+V ++      V   G   + VA+KKM+L  QQRRELLFNEV+ MR+Y H N+VE + SYLV DELWVVME+L+GG LTDIVT  R+  ++I T+C S+L AL  LH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQ+S +V RR SLVGTPYWMAPE+ISR PY   +DIWSLGIMVIEMVD EPPYF E PL+AMK IRD SP   ++  ++ P L+ FLD +L+++  +R  AS+LL+HPF   + P   S ++ L + N+
Sbjct:  351 SPQREPQRISHEQFRAALQMVVDPGDPRTYLDHYIKIGEGSTGIVCIA-----TVKTTG---KLVAVKKMDLKKQQRRELLFNEVVIMRDYHHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCVSVLKALSVLHSQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVQRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNSPPKLKNLHKVSPLLKGFLDRMLVREPAQRATASELLKHPFLAKSGPP--SCIVPLMRQNR 649
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Match: pak6a (p21 (RAC1) activated kinase 6 [Source:NCBI gene;Acc:101175447])

HSP 1 Score: 348.591 bits (893), Expect = 2.456e-111
Identity = 163/302 (53.97%), Postives = 219/302 (72.52%), Query Frame = 3 
Query:  654 TDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKYL 1559
            T E+F+ A++ +V+  DPR YL+   KIG+GSTGVV         ++ +    R VA+K M+L  QQRRELLFNEV+ MR+Y H N+VE F S LV++ELWV+MEYL GG LT+IV+  RL  ++I T+C+++L AL YLH  GVIHRDIKSD+ILL+  G++KLSDFGFCAQIS D+P+R SLVGTPYWMAPEVIS+ PY T +D+WS+GIMV+EMVD EPPYF E P+ AMK++RD    + R+  ++ P L+ FLD +L +D   R  A+DLL HPF  +   S + ++ L+E+Y K +
Sbjct:  400 THEQFKAALQMVVDKGDPRTYLENFVKIGEGSTGVV--------CIATEKHTGRQVAVKMMDLRRQQRRELLFNEVVIMRDYQHKNVVEMFKSALVEEELWVIMEYLQGGALTNIVSETRLSEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDIPKRKSLVGTPYWMAPEVISKSPYGTEVDVWSMGIMVVEMVDGEPPYFSETPVAAMKRLRDEQAPTVRNISQVSPVLKHFLDRMLTRDPLERASATDLLEHPFL-LQSGSPQCLVPLVEQYRKRM 692

HSP 2 Score: 50.447 bits (119), Expect = 4.976e-6
Identity = 36/112 (32.14%), Postives = 57/112 (50.89%), Query Frame = 3 
Query:   45 KKDISKPEKFRHVWHVEF--KNGHFKGLPPQWINLVK--EKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLPSGQS-----SNRQSITIVNSNSLHKTSSNNNRETKKSNQL 353
            + +IS P+ F H  H  F  K G F GLP QW +L++   +P    P+VD S+IT  E  P K IV    +  G       ++   +++ +SNSL K+S +  +  +   +L
Sbjct:    9 RPEISAPKNFEHRVHTSFDAKRGCFVGLPTQWQSLIENLRRP---KPMVDPSRITEVELRPKKTIVRGSMIGHGDYIAAMINDMSRLSVTSSNSLRKSSPSARKRAQSLGRL 117
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000022413.1 (SMESG000022413.1)

HSP 1 Score: 1030.78 bits (2664), Expect = 0.000e+0
Identity = 514/515 (99.81%), Postives = 514/515 (99.81%), Query Frame = 3 
Query:   30 MSALNKKDISKPEKFRHVWHVEFKNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNRQSITIVNSNSLHKTSSNNNRETKKSNQLIDKXXXXXXXXXXXXXYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKYLDNTGY 1574
            MSALNKKDISKPEKFRHVWHVEFKNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNRQSITIVNSNSLHKTSSNNNRETKKS QLIDKNNNNSLSNSTSQNYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKYLDNTGY
Sbjct:    1 MSALNKKDISKPEKFRHVWHVEFKNGHFKGLPPQWINLVKEKPGSRDPVVDKSKITSSEAVPFKQIVGSYRLPSGQSSNRQSITIVNSNSLHKTSSNNNRETKKSTQLIDKNNNNSLSNSTSQNYDSSHLKNNQNKQTISMERVLQKRITGNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLEKYNKYLDNTGY 515
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000036933.1 (SMESG000036933.1)

HSP 1 Score: 278.87 bits (712), Expect = 1.645e-85
Identity = 136/312 (43.59%), Postives = 197/312 (63.14%), Query Frame = 3 
Query:  612 SGNFPSLKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLVKD--ELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSILMLLE 1541
            S + P  +    + +D+E  + +K +V+  DP       +K+GQG++GVV+ S N            + +AIK+M L +Q +++L+ NE+L MR + H NIV    S+LV D  ELWVVMEYLDGG+LTD+VT   ++  +I T+C+  L AL++LH   VIHRDIKSD ILL   G++KL+DFGFCAQ+S+D+ +R ++VGTPYWMAPEV++++ Y   +D+WSLGIM +EM+D EPPY  E P++A+  I        +    M  E + FLD  L  D  +R  ASDLL HPF Q    S   ++ L++
Sbjct:  325 SNSAPRTRSKPVKVSDKEVIDRLKLVVSAGDPLEKYVLDEKVGQGASGVVYSSTNKS--------TGKPLAIKQMTLASQPKKDLIVNEILVMRAHRHPNIVNYLDSFLVDDNKELWVVMEYLDGGSLTDVVTEAFMQENQIATVCRETLQALEFLHSKHVIHRDIKSDNILLGLDGQVKLTDFGFCAQLSNDLTKRTTMVGTPYWMAPEVVTKKQYGPKVDVWSLGIMALEMLDGEPPYLNENPIKALYLIATNGKPDVKEAQNMSTEFKDFLDCCLEVDVEKRWSASDLLNHPFIQKKSESVNCLVELIK 628
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000008326.1 (SMESG000008326.1)

HSP 1 Score: 266.544 bits (680), Expect = 9.276e-81
Identity = 131/286 (45.80%), Postives = 181/286 (63.29%), Query Frame = 3 
Query:  657 DEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLV------KDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFF 1496
            +EE  E +++IV+  DP R  K+ +KIGQG++GVV+      GI ++ G   + VAIK+M L  Q ++EL+ NE+  M+   H N+V    SYLV       DELWVVMEYLDGG+LT++VT   ++   I  +C+  L ALD+LH + VIHRDIKSD ILL   G +KL+DFGFCAQ++++  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM +EM+D EPPY  E PL A+  I        +    +      FLD  L     +R  AS+LL HPF 
Sbjct:  330 EEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVY-----NGIETSTG---KKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFI 607
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000008326.1 (SMESG000008326.1)

HSP 1 Score: 266.159 bits (679), Expect = 9.685e-81
Identity = 131/286 (45.80%), Postives = 181/286 (63.29%), Query Frame = 3 
Query:  657 DEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLV------KDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFF 1496
            +EE  E +++IV+  DP R  K+ +KIGQG++GVV+      GI ++ G   + VAIK+M L  Q ++EL+ NE+  M+   H N+V    SYLV       DELWVVMEYLDGG+LT++VT   ++   I  +C+  L ALD+LH + VIHRDIKSD ILL   G +KL+DFGFCAQ++++  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM +EM+D EPPY  E PL A+  I        +    +      FLD  L     +R  AS+LL HPF 
Sbjct:  324 EEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVY-----NGIETSTG---KKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFI 601
[Close]
BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Match: SMESG000008326.1 (SMESG000008326.1)

HSP 1 Score: 265.774 bits (678), Expect = 1.205e-80
Identity = 131/286 (45.80%), Postives = 181/286 (63.29%), Query Frame = 3 
Query:  657 DEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENTGGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFGSYLV------KDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHFHGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMAPEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPMSSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFF 1496
            +EE  E +++IV+  DP R  K+ +KIGQG++GVV+      GI ++ G   + VAIK+M L  Q ++EL+ NE+  M+   H N+V    SYLV       DELWVVMEYLDGG+LT++VT   ++   I  +C+  L ALD+LH + VIHRDIKSD ILL   G +KL+DFGFCAQ++++  +R ++VGTPYWMAPEV++R+ Y   +D+WSLGIM +EM+D EPPY  E PL A+  I        +    +      FLD  L     +R  AS+LL HPF 
Sbjct:  323 EEEICEKLRKIVSLGDPNRKYKKHEKIGQGASGVVY-----NGIETSTG---KKVAIKQMQLKQQPKKELIINEICVMKANRHPNVVNYLDSYLVGGTGTVADELWVVMEYLDGGSLTEVVTETFMDEGHIAAVCRECLQALDFLHTNNVIHRDIKSDNILLGLDGSVKLTDFGFCAQLNNEQTKRSTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMALEMIDGEPPYLNENPLRALYLIATNGKPEIKEKSRLSVVFLDFLDKCLEVQVEKRISASELLTHPFI 600
The following BLAST results are available for this feature:
BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PAK41.276e-12142.01p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;... [more]
PAK45.151e-11555.23p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;... [more]
PAK45.151e-11555.23p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;... [more]
PAK42.494e-11456.19p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;... [more]
PAK42.494e-11456.19p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak-24.078e-10740.20Serine/threonine-protein kinase pak-2 [Source:Uni... [more]
pak-24.813e-10740.55Serine/threonine-protein kinase pak-2 [Source:Uni... [more]
pak-11.803e-8346.42Serine/threonine-protein kinase pak-1 [Source:Uni... [more]
pak-15.670e-8346.42Serine/threonine-protein kinase pak-1 [Source:Uni... [more]
pak-17.863e-8346.42Serine/threonine-protein kinase pak-1 [Source:Uni... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mbt1.215e-11655.33gene:FBgn0025743 transcript:FBtr0074285[more]
Pak1.298e-8847.92gene:FBgn0267698 transcript:FBtr0334539[more]
Pak1.298e-8847.92gene:FBgn0267698 transcript:FBtr0081714[more]
Pak1.298e-8847.92gene:FBgn0267698 transcript:FBtr0081716[more]
Pak1.298e-8847.92gene:FBgn0267698 transcript:FBtr0081715[more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak6b8.440e-11653.92p21 protein (Cdc42/Rac)-activated kinase 6b [Sourc... [more]
pak6b8.440e-11653.92p21 protein (Cdc42/Rac)-activated kinase 6b [Sourc... [more]
pak6a1.887e-11154.97p21 protein (Cdc42/Rac)-activated kinase 6a [Sourc... [more]
pak6a3.799e-11045.66p21 protein (Cdc42/Rac)-activated kinase 6a [Sourc... [more]
pak44.201e-11056.04p21 protein (Cdc42/Rac)-activated kinase 4 [Source... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
bri3bp3.117e-11355.15BRI3 binding protein [Source:Xenbase;Acc:XB-GENE-9... [more]
bri3bp3.258e-11355.15BRI3 binding protein [Source:Xenbase;Acc:XB-GENE-9... [more]
bri3bp3.551e-11355.15BRI3 binding protein [Source:Xenbase;Acc:XB-GENE-9... [more]
bri3bp4.241e-11355.15BRI3 binding protein [Source:Xenbase;Acc:XB-GENE-9... [more]
pou5f3.26.533e-11354.37POU class 5 homeobox 3, gene 2 [Source:Xenbase;Acc... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pak43.165e-11454.72p21 (RAC1) activated kinase 4 [Source:MGI Symbol;A... [more]
Pak43.165e-11454.72p21 (RAC1) activated kinase 4 [Source:MGI Symbol;A... [more]
Pak72.916e-11255.18p21 (RAC1) activated kinase 7 [Source:MGI Symbol;A... [more]
Pak72.916e-11255.18p21 (RAC1) activated kinase 7 [Source:MGI Symbol;A... [more]
Pak61.195e-10855.63p21 (RAC1) activated kinase 6 [Source:MGI Symbol;A... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9VXE5|PAKM_DROME1.217e-11555.33Serine/threonine-protein kinase PAK mbt OS=Drosoph... [more]
sp|O96013|PAK4_HUMAN1.198e-11356.19Serine/threonine-protein kinase PAK 4 OS=Homo sapi... [more]
sp|Q8BTW9|PAK4_MOUSE2.214e-11354.72Serine/threonine-protein kinase PAK 4 OS=Mus muscu... [more]
sp|D4A280|PAK5_RAT7.466e-11249.31Serine/threonine-protein kinase PAK 5 OS=Rattus no... [more]
sp|Q8C015|PAK5_MOUSE2.040e-11155.18Serine/threonine-protein kinase PAK 5 OS=Mus muscu... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4W5JGB13.235e-12041.93Non-specific serine/threonine protein kinase OS=Hu... [more]
A0A0L8GFF91.806e-11942.00Non-specific serine/threonine protein kinase OS=Oc... [more]
A0A5N4AP085.448e-11940.53Uncharacterized protein OS=Photinus pyralis OX=705... [more]
A0A1Y1K9C51.799e-11840.35Non-specific serine/threonine protein kinase OS=Ph... [more]
H2Y4H81.876e-11843.59Non-specific serine/threonine protein kinase OS=Ci... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak71.473e-11356.38p21 (RAC1) activated kinase 5 [Source:NCBI gene;Ac... [more]
pak75.342e-11356.38p21 (RAC1) activated kinase 5 [Source:NCBI gene;Ac... [more]
pak76.838e-11356.38p21 (RAC1) activated kinase 5 [Source:NCBI gene;Ac... [more]
pak77.740e-11356.38p21 (RAC1) activated kinase 5 [Source:NCBI gene;Ac... [more]
pak6b6.643e-11254.30serine/threonine-protein kinase PAK 6-like [Source... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak48.061e-11356.38p21 protein (Cdc42/Rac)-activated kinase 4 [Source... [more]
pak44.296e-5354.27p21 protein (Cdc42/Rac)-activated kinase 4 [Source... [more]
pak49.902e-5354.27p21 protein (Cdc42/Rac)-activated kinase 4 [Source... [more]
stk25a2.101e-5236.99serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-G... [more]
MAP4K38.317e-4735.86mitogen-activated protein kinase kinase kinase kin... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
STE204.613e-7645.42Cdc42p-activated signal transducing kinase; involv... [more]
CLA42.287e-6639.53Cdc42p-activated signal transducing kinase; member... [more]
SKM12.995e-6229.03Member of the PAK family of serine/threonine prote... [more]
KIC13.504e-4235.19Protein kinase of the PAK/Ste20 family, required f... [more]
TPK25.946e-3428.52cAMP-dependent protein kinase catalytic subunit; p... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO458461.584e-11557.79Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO336671.006e-8641.79Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO490472.211e-4934.93Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO428452.470e-4932.80Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO319344.932e-4934.35Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak47.421e-11356.71p21 (RAC1) activated kinase 4 [Source:NCBI gene;Ac... [more]
pak77.719e-11356.04p21 (RAC1) activated kinase 5 [Source:NCBI gene;Ac... [more]
pak79.956e-11356.04p21 (RAC1) activated kinase 5 [Source:NCBI gene;Ac... [more]
pak41.198e-11155.02p21 (RAC1) activated kinase 4 [Source:NCBI gene;Ac... [more]
pak6a2.456e-11153.97p21 (RAC1) activated kinase 6 [Source:NCBI gene;Ac... [more]
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BLAST of Non-specific serine/threonine protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000022413.10.000e+099.81SMESG000022413.1[more]
SMESG000036933.11.645e-8543.59SMESG000036933.1[more]
SMESG000008326.19.276e-8145.80SMESG000008326.1[more]
SMESG000008326.19.685e-8145.80SMESG000008326.1[more]
SMESG000008326.11.205e-8045.80SMESG000008326.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008195 ID=SMED30008195|Name=Non-specific serine/threonine protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1731bp
AATCTATATAAATCTTATATGGGTTTTAGATGAGTGCATTAAATAAAAAA
GACATTTCTAAGCCTGAAAAATTTAGACATGTTTGGCATGTGGAATTTAA
AAATGGTCATTTCAAAGGACTGCCTCCTCAATGGATTAATTTAGTGAAAG
AAAAACCTGGATCAAGGGATCCAGTTGTTGATAAATCTAAAATCACATCA
TCGGAAGCAGTTCCATTTAAGCAAATAGTTGGATCATATCGTTTACCAAG
TGGTCAATCTAGCAATCGTCAGTCAATCACAATTGTAAATTCCAATTCAT
TACACAAAACTAGCTCAAATAATAATAGAGAAACCAAAAAATCAAATCAA
CTCATTGATAAAAACAATAACAATTCTTTATCAAATTCCACCTCTCAAAA
TTATGATTCTTCGCACCTCAAAAATAACCAAAATAAACAGACTATTTCAA
TGGAACGAGTTTTACAAAAAAGAATCACAGGTAATTCTAGCGTTCAAATT
AGGACTCCCAGTCAACATAGAGTTTTGCGAAAATCTAATCTATCGATTCA
CTCAGATTCAGCTTTGTTGAGATCTAAAAGCGTGATAGAATTGTCAGACC
AAAACTCATCTTCAGGTAATTTCCCCAGTCTCAAAAAATCCGATGGCCAA
TATACTGATGAAGAGTTCCGTGAAGCTATAAAAGAAATTGTTAACCCTCA
AGATCCGCGTCGATATTTGAAAGAAATAAAGAAGATCGGTCAAGGAAGTA
CTGGTGTTGTATTTTTATCGGAAAATACTGGCGGAATAGTCTCAAATAAA
GGAGATTTTAATAGATATGTCGCAATAAAAAAAATGAATTTATTCAATCA
ACAGAGACGAGAACTCTTGTTTAATGAAGTTCTGACCATGAGAAATTACT
CACATGTAAACATTGTTGAAACGTTTGGTAGTTACCTGGTGAAGGATGAA
TTGTGGGTTGTGATGGAGTACTTGGACGGTGGAACATTGACTGATATAGT
TACTCGAATAAGACTGGAGCCGCAAGAAATATGCACGATTTGCAAATCAA
TCTTGAATGCCTTGGATTATTTACATTTTCATGGAGTGATTCACAGGGAT
ATTAAATCAGATGCTATTCTTTTATCTAGGAAAGGAAAAATTAAATTGTC
AGATTTTGGATTTTGTGCCCAAATCAGTTCTGATGTTCCTAGGCGGTGTA
GTTTAGTTGGAACTCCTTATTGGATGGCCCCTGAAGTAATCTCACGTCAA
CCATATAATACATCGATTGATATCTGGTCGTTGGGAATTATGGTCATTGA
AATGGTTGATAGTGAACCACCGTACTTTAGAGAAAGACCTCTTGAAGCAA
TGAAGAAGATTCGCGATTTGTCACCAATGTCTTCTAGGCATTACGATGAA
ATGCCCCCAGAATTGCAGGCTTTCCTTGATTCATTGCTGATCAAGGATGA
CAGGCGACGACCAAAGGCGTCTGATTTATTACGTCACCCATTTTTTCAAA
TCACGCAGCCTTCCACCCGGTCTATTCTTATGTTATTGGAAAAGTACAAT
AAGTATTTAGATAATACAGGCTACTGATTTATTTTTATTTTTCCAAAAAC
ATGTGCACATATCACTACATTGATATTTGTATTAAAAAATTCTTTATTCG
TAGTTTGGTTGATCTCTGATATCCTATTTTTGGCTTTAATTTCGACAGAA
AAGTTATTTTGTTAAATAGACAATATTCTGC
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protein sequence of SMED30008195-orf-1

>SMED30008195-orf-1 ID=SMED30008195-orf-1|Name=SMED30008195-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=516bp
MSALNKKDISKPEKFRHVWHVEFKNGHFKGLPPQWINLVKEKPGSRDPVV
DKSKITSSEAVPFKQIVGSYRLPSGQSSNRQSITIVNSNSLHKTSSNNNR
ETKKSNQLIDKNNNNSLSNSTSQNYDSSHLKNNQNKQTISMERVLQKRIT
GNSSVQIRTPSQHRVLRKSNLSIHSDSALLRSKSVIELSDQNSSSGNFPS
LKKSDGQYTDEEFREAIKEIVNPQDPRRYLKEIKKIGQGSTGVVFLSENT
GGIVSNKGDFNRYVAIKKMNLFNQQRRELLFNEVLTMRNYSHVNIVETFG
SYLVKDELWVVMEYLDGGTLTDIVTRIRLEPQEICTICKSILNALDYLHF
HGVIHRDIKSDAILLSRKGKIKLSDFGFCAQISSDVPRRCSLVGTPYWMA
PEVISRQPYNTSIDIWSLGIMVIEMVDSEPPYFRERPLEAMKKIRDLSPM
SSRHYDEMPPELQAFLDSLLIKDDRRRPKASDLLRHPFFQITQPSTRSIL
MLLEKYNKYLDNTGY*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0004674protein serine/threonine kinase activity
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0016301kinase activity
GO:0016740transferase activity
Vocabulary: biological process
TermDefinition
GO:0006915apoptotic process
GO:0007010cytoskeleton organization
GO:0006468protein phosphorylation
GO:0006464cellular protein modification process
GO:0016310phosphorylation
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000017photoreceptor neuron
PLANA:0000034epidermis
Vocabulary: INTERPRO
TermDefinition
IPR036936CRIB_dom_sf
IPR035066PAK6
IPR000719Prot_kinase_dom
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
IPR000095CRIB_dom
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000095CRIB domainSMARTSM00285PBD_5coord: 9..42
e-value: 3.7E-4
score: 29.8
IPR000095CRIB domainPFAMPF00786PBDcoord: 8..43
e-value: 3.2E-6
score: 27.4
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 231..489
e-value: 5.3E-62
score: 209.6
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 230..489
score: 47.58
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 315..508
e-value: 8.9E-63
score: 213.2
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 178..314
e-value: 2.2E-34
score: 121.0
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 88..138
NoneNo IPR availablePANTHERPTHR45832FAMILY NOT NAMEDcoord: 206..509
coord: 7..194
IPR036936CRIB domain superfamilyGENE3DG3DSA:3.90.810.10coord: 4..42
e-value: 4.8E-9
score: 37.7
IPR035066Serine/threonine-protein kinase PAK 6PANTHERPTHR45832:SF3NON-SPECIFIC SERINE/THREONINE PROTEIN KINASEcoord: 206..509
coord: 7..194
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 236..268
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 226..494