Connector enhancer of kinase suppressor of ras 2

Overview
NameConnector enhancer of kinase suppressor of ras 2
Smed IDSMED30008165
Length (bp)3133
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Connector enhancer of kinase suppressor of ras 2 (SMED30008165) t-SNE clustered cells

Violin plots show distribution of expression levels for Connector enhancer of kinase suppressor of ras 2 (SMED30008165) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Connector enhancer of kinase suppressor of ras 2 (SMED30008165) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Connector enhancer of kinase suppressor of ras 2 (SMED30008165) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30008165

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30008165SMESG000044449.1 SMESG000044448.1 dd_Smed_v4_4457_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30008165SMESG000044449.1 SMESG000044448.1 dd_Smed_v4_4457_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30008165SMESG000044449.1 SMESG000044448.1 dd_Smed_v4_4457_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30008165SMESG000044449.1 SMESG000044448.1 dd_Smed_v4_4457_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30008165SMESG000044449.1 SMESG000044448.1 dd_Smed_v4_4457_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
anterior sideSMED30008165SMESG000044449.1 SMESG000044448.1 dd_Smed_v4_4457_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30008165SMESG000044449.1 SMESG000044448.1 dd_Smed_v4_4457_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Human
Match: CNKSR3 (CNKSR family member 3 [Source:HGNC Symbol;Acc:HGNC:23034])

HSP 1 Score: 110.923 bits (276), Expect = 1.638e-24
Identity = 79/327 (24.16%), Postives = 156/327 (47.71%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ--YIVSDKGDQKFADVK---GISN-MIRYRTQSFIDSCRDSLYLTPCI--IDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            +  WS  +V  W RG+  CL +Y+  F++   +G  L  +S  DL+ +G  +IGH  ++L++V +L    + +  + ++N++ ++  ++ +L NY+                R SP YD      N+ +  P +           ++SV++L  +    L+WL++  F  +++    K  ++     L    Q    V++  D+    VK   GI +  IR  T   +  C        C+  +    I   E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N Q ++GW  +++++++R +P  + L L+K+P
Sbjct:    4 VTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYIS-------------SRRKSPAYDG-----NTSRKAPNEF----------LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCA-------CLEEVHLPNIKPGEGL--GMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRP 293
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Human
Match: AL357075.4 (CNK3/IPCEF1 fusion protein [Source:UniProtKB/Swiss-Prot;Acc:G9CGD6])

HSP 1 Score: 111.694 bits (278), Expect = 2.861e-24
Identity = 77/325 (23.69%), Postives = 154/325 (47.38%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ--YIVSDKGDQKFADVK---GISN-MIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            +  WS  +V  W RG+  CL +Y+  F++   +G  L  +S  DL+ +G  +IGH  ++L++V +L    + +  + ++N++ ++  ++ +L NY+                R SP YD      N+ +  P +           ++SV++L  +    L+WL++  F  +++    K  ++     L    Q    V++  D+    VK   GI +  IR  T   +  C        C+ +    +       G+ +K+ +  LH+I     NSPA    K+  GDE++++N Q ++GW  +++++++R +P  + L L+K+P
Sbjct:    4 VTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYIS-------------SRRKSPAYDG-----NTSRKAPNEF----------LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCA-------CLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRP 293
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Human
Match: CNKSR2 (connector enhancer of kinase suppressor of Ras 2 [Source:HGNC Symbol;Acc:HGNC:19701])

HSP 1 Score: 95.1301 bits (235), Expect = 4.269e-19
Identity = 83/385 (21.56%), Postives = 173/385 (44.94%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNM-----------PQNAGNSGQLRGGVLTRPSKRINQA 1117
            + +  ++ WS  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD       S++L P             ++SV+ L  +    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I       I    D L      ++ +Q   I  +E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P  +   + S     +NM           P++  +S       ++ P+KR + A
Sbjct:    3 LIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITG-------------RRRSGHYDGR----TSRKL-PNDF----------LTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHI-------ISLSSDPLVSQSAHLEVIQLANIKPSEGL--GMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM---LTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSA 347
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Human
Match: CNKSR2 (connector enhancer of kinase suppressor of Ras 2 [Source:HGNC Symbol;Acc:HGNC:19701])

HSP 1 Score: 94.3597 bits (233), Expect = 4.588e-19
Identity = 82/375 (21.87%), Postives = 170/375 (45.33%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNMPQNAGNSGQLRGGVLTRPSKRINQAGLLG 1129
            + +  ++ WS  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD       S++L P             ++SV+ L  +    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I   +   + S   S +L   +I    I  +E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P  +   + S     +NM          +   L   SK+ N+  + G
Sbjct:    3 LIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITG-------------RRRSGHYDGR----TSRKL-PNDF----------LTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVS--QSAHLE--VIQLANIKPSEGL--GMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM---LTSAPALLKNMRWKPLALQTFQQSSLQHKSKKKNKGPIAG 340
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Human
Match: CNKSR2 (connector enhancer of kinase suppressor of Ras 2 [Source:HGNC Symbol;Acc:HGNC:19701])

HSP 1 Score: 94.7449 bits (234), Expect = 5.118e-19
Identity = 83/385 (21.56%), Postives = 173/385 (44.94%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNM-----------PQNAGNSGQLRGGVLTRPSKRINQA 1117
            + +  ++ WS  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD       S++L P             ++SV+ L  +    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I       I    D L      ++ +Q   I  +E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P  +   + S     +NM           P++  +S       ++ P+KR + A
Sbjct:    3 LIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITG-------------RRRSGHYDGR----TSRKL-PNDF----------LTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHI-------ISLSSDPLVSQSAHLEVIQLANIKPSEGL--GMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM---LTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSA 347
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Celegans
Match: cnk-1 (Connector enhancer of kinase suppressor of ras [Source:UniProtKB/Swiss-Prot;Acc:G5EEW9])

HSP 1 Score: 94.7449 bits (234), Expect = 1.788e-19
Identity = 79/331 (23.87%), Postives = 152/331 (45.92%), Query Frame = 2 
Query:   26 FLYNINNWSGDEVESWIRGISPCLSEYLPFDKPSC-DGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNK------PNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHK-TENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRS-HPRKLSLRLRKKP 991
            F   +  W G E+  WI G+   ++ YL   + +   G+ L  L    LK +G   +G    +  +V +L+   H+  +E LQ +  +V  +   +   +   +R+ E                             +  EI +I   + ++VL+L       + WL++      P FI+V   V   +  L  L+ +N   + +  + G Q    +  +S  + Y  Q  +D C D L L  C I++  + + ++NI +G+N+++ +  +H+I  I   SPA +  K++ GDEIL IN + ++GW   SV++++ +    +LSL ++++P
Sbjct:   49 FARCVEQWKGKEIARWIEGLGDQMNPYLGMIRDNIKSGKQLEALDDDSLKKIGISALGARKTIFQAVSLLLYFCHESEHENLQRLAQQVKTSCLYVERTMTSAMRMREKA--------------------------IRRSEIVNILNSVSNAVLQLAEHTKRFVFWLDRTPFDEEPEFINVRNSVSSFMWNL--LRNVNVQPKALF-ETGSQ----IVRMSKELAYECQKIVD-CDDPLILYACFIESALLRRRSDNINWGLNIQSSYRGVHVISEIKEGSPADACTKIDAGDEILMINGRTVVGWDLTSVVQQVGALDVLELSLIVKRRP 345
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Fly
Match: cnk (gene:FBgn0286070 transcript:FBtr0086962)

HSP 1 Score: 77.411 bits (189), Expect = 5.547e-14
Identity = 35/101 (34.65%), Postives = 62/101 (61.39%), Query Frame = 2 
Query:  698 IDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHV 1000
            I    D + L P  ++ V + K E+   G N+++ +  +H +  I  NSPA++ GK+E+GDEI++IN Q ++GW H++V+E +R     + L ++K+P H 
Sbjct:  190 IQDISDPMVLQPASLNLVTLKKRES-ELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHT 289

HSP 2 Score: 57.3806 bits (137), Expect = 9.312e-8
Identity = 31/93 (33.33%), Postives = 52/93 (55.91%), Query Frame = 2 
Query:   35 NINNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSL 310
            NI  W+ D+V  WI+G+   +  YL  F K    GR L N+   +L+++G  +IGH  I+L++V  L +  + + N+ LQ +   V+  A +L
Sbjct:    5 NIAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVENLRNFHYHLKNDNLQFMALHVATAAKNL 97
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Fly
Match: cnk (gene:FBgn0286070 transcript:FBtr0340214)

HSP 1 Score: 77.411 bits (189), Expect = 5.547e-14
Identity = 35/101 (34.65%), Postives = 62/101 (61.39%), Query Frame = 2 
Query:  698 IDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHV 1000
            I    D + L P  ++ V + K E+   G N+++ +  +H +  I  NSPA++ GK+E+GDEI++IN Q ++GW H++V+E +R     + L ++K+P H 
Sbjct:  190 IQDISDPMVLQPASLNLVTLKKRES-ELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHT 289

HSP 2 Score: 57.3806 bits (137), Expect = 9.312e-8
Identity = 31/93 (33.33%), Postives = 52/93 (55.91%), Query Frame = 2 
Query:   35 NINNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSL 310
            NI  W+ D+V  WI+G+   +  YL  F K    GR L N+   +L+++G  +IGH  I+L++V  L +  + + N+ LQ +   V+  A +L
Sbjct:    5 NIAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVENLRNFHYHLKNDNLQFMALHVATAAKNL 97
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Zebrafish
Match: si:ch211-26b3.4 (si:ch211-26b3.4 [Source:ZFIN;Acc:ZDB-GENE-081104-60])

HSP 1 Score: 99.7525 bits (247), Expect = 1.009e-20
Identity = 76/330 (23.03%), Postives = 157/330 (47.58%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQY--IVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIV----FGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  I+ WS  +V  W++G+  CL +Y+  F++    G  L +++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++    R      H+   R+S    N+                        ++SV+ L  +    L+WL++  F+SVSE   +K  ++     L    Q    V +  ++     K +S +  +     I    DSL      ++ V +    N++     G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P
Sbjct:    3 LVMEPISKWSPKQVLDWMKGLDDCLLQYMRTFEREQITGEQLLHITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLRTLSHKLNASAKNLQNFITGRRRGG----HY-DGRVSRRLPND-----------------------FLTSVVDLIGAAKNLLAWLDRSPFVSVSEYSVLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLSGICEH----IISLSSDSLVSQSAHLEVVHL---TNVMPSEGLGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNHQTVVGWQLKNLVNCLREDPSGVILTLKKRP 297
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Zebrafish
Match: cnksr2a (connector enhancer of kinase suppressor of Ras 2a [Source:ZFIN;Acc:ZDB-GENE-060228-5])

HSP 1 Score: 96.6709 bits (239), Expect = 5.495e-20
Identity = 72/332 (21.69%), Postives = 151/332 (45.48%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  ++ WS  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD                   + +    ++SV+ L  +    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I       I    D L      ++ VQ   I  TE +  G+ +K+ +  LH+I      SPA    K+  GDE++++N+Q ++GW  ++++  +R  P  ++L L+K+P
Sbjct:   16 LVMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKVGGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITG-------------RRRSGHYDGRT---------------TRKLPNDFLTSVVDLIAAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHI-------ISLSSDPLVSQSAHLEVVQLANIKPTEGL--GMYIKSTYDGLHVITGTTEGSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVSSLRGDPAGVTLTLKKRP 310
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Zebrafish
Match: cnksr2a (connector enhancer of kinase suppressor of Ras 2a [Source:ZFIN;Acc:ZDB-GENE-060228-5])

HSP 1 Score: 95.9005 bits (237), Expect = 1.574e-19
Identity = 72/332 (21.69%), Postives = 151/332 (45.48%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  ++ WS  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD                   + +    ++SV+ L  +    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I       I    D L      ++ VQ   I  TE +  G+ +K+ +  LH+I      SPA    K+  GDE++++N+Q ++GW  ++++  +R  P  ++L L+K+P
Sbjct:    3 LVMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKVGGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITG-------------RRRSGHYDGRT---------------TRKLPNDFLTSVVDLIAAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHI-------ISLSSDPLVSQSAHLEVVQLANIKPTEGL--GMYIKSTYDGLHVITGTTEGSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVSSLRGDPAGVTLTLKKRP 297
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Zebrafish
Match: cnksr2b (connector enhancer of kinase suppressor of Ras 2b [Source:ZFIN;Acc:ZDB-GENE-030131-8048])

HSP 1 Score: 93.2041 bits (230), Expect = 1.097e-18
Identity = 70/332 (21.08%), Postives = 151/332 (45.48%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  ++ WS  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R    YD                   + +    ++SV+ L  +    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I       I    D +      ++ VQ   I  TE +  G+ +K+ +  LH+I      S A    K+  GDE++++N+Q ++GW  ++++  +RS+P  ++L L+K+P
Sbjct:    3 LVMEPVSRWSTSQVVDWMKGLDDCLQQYIKNFEQEKVGGEQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLTHKLNASAKNLQNFITG-------------RRRGGHYDGR---------------ATRKLPNDFLTSVVDLIAAAKSLLAWLDRSPFAAVADYSMTRNNVIQLCLELTTIVQQDGTVYETENKILHVCKTLSGVCDHI-------IALSSDPMVSQAAHLEVVQLDNIRSTEGL--GMYIKSTYDGLHVITGTTEGSLADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNSLRSNPAGVTLTLKKRP 297
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Zebrafish
Match: cnksr3 (cnksr family member 3 [Source:ZFIN;Acc:ZDB-GENE-080204-43])

HSP 1 Score: 89.3521 bits (220), Expect = 8.386e-18
Identity = 69/328 (21.04%), Postives = 144/328 (43.90%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIV---------FGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            I  W+  +V  WIRG+   L +Y+  F++    G  L  +S  +L+ +   ++GH  ++L++V +L      +  + L+ ++ ++   + +L N                + R +P YD       S    P           + +++V++L  +    L+WL++     VS+    K  ++     L    Q         K   V  +   I   +Q     C  ++ +T   + T Q+   E +           G+ +K+ +  LH+I     NSPA    ++  GDE++++N Q ++GW  ++++E++R  P+ ++L ++K+P
Sbjct:    4 ITKWTAAQVVDWIRGLDDSLQQYISNFEREKISGERLLKISHQELEELSVTRVGHQELILEAVDLLCALNCGVETDNLKTLVGQMRAASNNLQNCAS-------------ERRKNPSYDG-----GSPNKPPN----------VFLTAVVELIGAAKSMLAWLDRSPLTGVSDFTTTKNKIIQLCLELTTTVQ---------KDCTVFEMEEKILEVSQVLTGICDSTMRMTSDPLKT-QVTCLEEVPISNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRTQRIHAGDEVIQVNKQTVVGWQLKNLVEKLREDPQNVTLMVKKRP 293
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Xenopus
Match: adamts10 (ADAM metallopeptidase with thrombospondin type 1 motif 10 [Source:Xenbase;Acc:XB-GENE-961723])

HSP 1 Score: 101.679 bits (252), Expect = 3.331e-21
Identity = 80/333 (24.02%), Postives = 158/333 (47.45%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIV----FGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  I+ WS  +V  W++G+  CL +Y+  F++   +G  L +++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD       S++L P             ++SV+ L  +    L+WL++  F+SV+E   +K  ++     L    Q     Y   +K       + GI + I       I    DSL      ++ V +    NI+     G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P
Sbjct:    3 LVMEPISKWSPKQVVDWMKGLDDCLQQYIKNFEREKINGEQLLHITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLRTLSHKLNASAKNLQNFITG-------------RRRSGHYDGR----ASRRL-PNDF----------LTSVVDLIGAAKNLLAWLDRSPFVSVTEYSLLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLSGICDHI-------ISLSSDSLVSQSAHLEVVHL---TNIMPSEGLGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPNGVILTLKKRP 297
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Xenopus
Match: mul1a (mitochondrial E3 ubiquitin protein ligase 1a [Source:Xenbase;Acc:XB-GENE-5839754])

HSP 1 Score: 94.7449 bits (234), Expect = 4.415e-19
Identity = 82/385 (21.30%), Postives = 174/385 (45.19%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNM-----------PQNAGNSGQLRGGVLTRPSKRINQA 1117
            + +  ++ W+  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD +    +S++L P             ++SV+ L  S    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I       I    D L      ++ +Q   I  +E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P  +   + S     +NM           P++  +        ++ P+KR + A
Sbjct:    3 LIMEPVSKWTPSQVVDWMKGLDDCLQQYIKNFEREKIAGDQLLRITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNSSAKNLQNFITG-------------RRRSGHYDGK----SSRKL-PNDF----------LTSVVDLIGSAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQECTVYETENKILHVCKTLSGVCDHI-------ISLSSDPLVSQSAHLEVIQLSNIKPSEGL--GMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM---LTSAPALLKNMRWKPLALQPLIPRSPTSGAATPSSTISTPTKRDSSA 347
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Xenopus
Match: mul1a (mitochondrial E3 ubiquitin protein ligase 1a [Source:Xenbase;Acc:XB-GENE-5839754])

HSP 1 Score: 94.3597 bits (233), Expect = 6.111e-19
Identity = 82/385 (21.30%), Postives = 174/385 (45.19%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNM-----------PQNAGNSGQLRGGVLTRPSKRINQA 1117
            + +  ++ W+  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD +    +S++L P             ++SV+ L  S    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I       I    D L      ++ +Q   I  +E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P  +   + S     +NM           P++  +        ++ P+KR + A
Sbjct:    3 LIMEPVSKWTPSQVVDWMKGLDDCLQQYIKNFEREKIAGDQLLRITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNSSAKNLQNFITG-------------RRRSGHYDGK----SSRKL-PNDF----------LTSVVDLIGSAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQECTVYETENKILHVCKTLSGVCDHI-------ISLSSDPLVSQSAHLEVIQLSNIKPSEGL--GMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM---LTSAPALLKNMRWKPLALQPLIPRSPTSGAATPSSTISTPTKRDSSA 347
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Xenopus
Match: mul1a (mitochondrial E3 ubiquitin protein ligase 1a [Source:Xenbase;Acc:XB-GENE-5839754])

HSP 1 Score: 93.5893 bits (231), Expect = 8.030e-19
Identity = 75/334 (22.46%), Postives = 160/334 (47.90%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSE-------LVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  ++ W+  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD +    +S++L P             ++SV+ L  S    L+WL++  F +V++       ++ + L L   +++    T Y   +K       + G+ + I       I    D L      ++ +Q   I  +E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P
Sbjct:    3 LIMEPVSKWTPSQVVDWMKGLDDCLQQYIKNFEREKIAGDQLLRITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNSSAKNLQNFITG-------------RRRSGHYDGK----SSRKL-PNDF----------LTSVVDLIGSAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQ--ECTVYETENKILHVCKTLSGVCDHI-------ISLSSDPLVSQSAHLEVIQLSNIKPSEGL--GMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRP 297
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Xenopus
Match: mul1a (mitochondrial E3 ubiquitin protein ligase 1a [Source:Xenbase;Acc:XB-GENE-5839754])

HSP 1 Score: 86.6557 bits (213), Expect = 1.342e-16
Identity = 76/348 (21.84%), Postives = 158/348 (45.40%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMK---LGLLDDLKRLNRYTQYIVSDKGD-----------QKFADVKGISNMIRYRTQSFIDSC-------RDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  ++ W+  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD +    +S++L P             ++SV+ L  S    L+WL++       ++ ++K   +G   D       T Y V+               Q+   V    N I +  ++    C        D L      ++ +Q   I  +E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P
Sbjct:    3 LIMEPVSKWTPSQVVDWMKGLDDCLQQYIKNFEREKIAGDQLLRITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNSSAKNLQNFI-------------TGRRRSGHYDGK----SSRKL-PNDF----------LTSVVDLIGSAKSLLAWLDRYCHADQDDIDNLKKRWIGHKLDKSPFAAVTDYSVTRNNVIQLCLELTTIVQQECTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLSNIKPSEGL--GMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRP 320
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Mouse
Match: Cnksr3 (Cnksr family member 3 [Source:MGI Symbol;Acc:MGI:2674130])

HSP 1 Score: 112.849 bits (281), Expect = 2.540e-25
Identity = 77/327 (23.55%), Postives = 158/327 (48.32%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ--YIVSDKGDQKFADVKGISNMIRYRTQSFID------SCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            +  WS  +V  W RG+  CL  Y+  F++   DG  L  +S  DL+ +G  +IGH  ++L++V +L    + +  +T++N++ ++  ++ +L NY+                R SP YD      N+ +  P +           ++SV++L  +    L+WL++  F  +++L   K  ++     L    Q   ++++  D+    VK ++ +     +S  D      +C + ++L         +   E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N Q ++GW  ++++ ++R +P  + L L+K+P
Sbjct:    4 VTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDTMKNLVLKLRASSHNLQNYIS-------------SRRKSPAYDG-----NTSRKPPNEF----------LTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLCLDLTTAVQKDCLIAEMEDKVLNVVKVLNGICDKTMRSTTDPVMSQCACLEEVHLP-------NVRPGEGL--GMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVRKLRENPTGVVLLLKKRP 293
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Mouse
Match: Cnksr2 (connector enhancer of kinase suppressor of Ras 2 [Source:MGI Symbol;Acc:MGI:2661175])

HSP 1 Score: 94.7449 bits (234), Expect = 3.509e-19
Identity = 83/385 (21.56%), Postives = 173/385 (44.94%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNM-----------PQNAGNSGQLRGGVLTRPSKRINQA 1117
            + +  ++ WS  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD       S++L P             ++SV+ L  +    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I       I    D L      ++ +Q   I  +E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P  +   + S     +NM           P++  +S       ++ P+KR + A
Sbjct:    3 LIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITG-------------RRRSGHYDGR----TSRKL-PNDF----------LTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHI-------ISLSSDPLVSQSAHLEVIQLANIKPSEGL--GMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM---LTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSA 347
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Mouse
Match: Cnksr2 (connector enhancer of kinase suppressor of Ras 2 [Source:MGI Symbol;Acc:MGI:2661175])

HSP 1 Score: 94.3597 bits (233), Expect = 4.734e-19
Identity = 83/385 (21.56%), Postives = 173/385 (44.94%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNM-----------PQNAGNSGQLRGGVLTRPSKRINQA 1117
            + +  ++ WS  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD       S++L P             ++SV+ L  +    L+WL++  F +V++    +  ++     L    Q     Y   +K       + G+ + I       I    D L      ++ +Q   I  +E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P  +   + S     +NM           P++  +S       ++ P+KR + A
Sbjct:    3 LIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFI-------------TGRRRSGHYDGR----TSRKL-PNDF----------LTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHI-------ISLSSDPLVSQSAHLEVIQLANIKPSEGL--GMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM---LTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSA 347
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Mouse
Match: Cnksr1 (connector enhancer of kinase suppressor of Ras 1 [Source:MGI Symbol;Acc:MGI:2670958])

HSP 1 Score: 78.9518 bits (193), Expect = 1.997e-14
Identity = 79/378 (20.90%), Postives = 156/378 (41.27%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYLPFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSEL-VDMKLGLLDDLKRLNRYTQYIVSDKGD-QKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPM---HVNESINSGGRRNRNMPQNAGNSGQLRGGVLTRPSKRINQAGLLGSVSTPATPV 1156
            +  W+  +V +W+RG+   L +Y PF+     G++L  L    L+++    +GH  ++LD V  L      +  E LQ++       A  L+                             Q F S  L  G L         ++ + ++L       LSWLN   F  +++     ++G+L          Q +  D  + +K  ++  I + +     + +    + L     ++++VQ+        G+ + T    LH +  + +   A +  ++  GDEI+++N Q+++GW H++++ E+   P K+SL L+K P+       S++S    ++++P N              PS R+   GLL   +   +P 
Sbjct:    4 VEAWTPGKVAAWLRGLDDALQDY-PFEDWQLPGKYLLQLCPQSLEALTVWPLGHQELILDGVEQLRALGSNLQTENLQSL-------AQGLLERT--------------------------QAFQS--LVQGSLGNCAETPADVLKAAVELVREAHALLSWLNGYLFSHLNDFSACQEIGVL-----CGELGQVLQEDCPEAEKERNILRICSHVAGICHNILSCSPEELLEQKAVLESVQVDDPS----GLEIHTTSNCLHFVSRVGVQ--AATSSQILPGDEIVQVNEQVVVGWSHKNMLRELLREPAKVSLVLKKIPVPETPSQTSLDSPHLLSQSLPLNP-------------PSPRVPSEGLLADGTPGPSPA 321
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. UniProt/SwissProt
Match: sp|Q8BMA3|CNKR3_MOUSE (Connector enhancer of kinase suppressor of ras 3 OS=Mus musculus OX=10090 GN=Cnksr3 PE=1 SV=1)

HSP 1 Score: 112.849 bits (281), Expect = 1.777e-24
Identity = 77/327 (23.55%), Postives = 158/327 (48.32%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ--YIVSDKGDQKFADVKGISNMIRYRTQSFID------SCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            +  WS  +V  W RG+  CL  Y+  F++   DG  L  +S  DL+ +G  +IGH  ++L++V +L    + +  +T++N++ ++  ++ +L NY+                R SP YD      N+ +  P +           ++SV++L  +    L+WL++  F  +++L   K  ++     L    Q   ++++  D+    VK ++ +     +S  D      +C + ++L         +   E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N Q ++GW  ++++ ++R +P  + L L+K+P
Sbjct:    4 VTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDTMKNLVLKLRASSHNLQNYIS-------------SRRKSPAYDG-----NTSRKPPNEF----------LTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLCLDLTTAVQKDCLIAEMEDKVLNVVKVLNGICDKTMRSTTDPVMSQCACLEEVHLP-------NVRPGEGL--GMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVRKLRENPTGVVLLLKKRP 293
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. UniProt/SwissProt
Match: sp|Q5SGD7|CNKR3_RAT (Connector enhancer of kinase suppressor of ras 3 OS=Rattus norvegicus OX=10116 GN=Cnksr3 PE=1 SV=1)

HSP 1 Score: 112.079 bits (279), Expect = 3.286e-24
Identity = 79/327 (24.16%), Postives = 159/327 (48.62%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ--YIVSDKGDQKFADVK---GISNMIRYRTQSFIDS---CRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            +  WS  +V  W RG+  CL  Y+  F++   DG  L  +S  DL+ +G  +IGH  ++L++V +L    + +  + ++N++ ++  ++ +L NY+                R SP YD      N+ +  P +           ++SV++L  +    L+WL++  F  +++L   K  ++     L    Q   +V++  D+    VK   GI + + + T   + S   C + ++L         +   E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N Q ++GW  +++++++R +P  + L L+K+P
Sbjct:    4 VTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYIS-------------SRRKSPAYDG-----NTSRKPPNEF----------LTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLCLDLTTAVQKDCLVAEMEDKVLNVVKVLNGICDKMMHSTTDPVMSQCACLEEVHLP-------NVRPGEGL--GMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVKKLRENPTGVVLLLKKRP 293
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. UniProt/SwissProt
Match: sp|Q6P9H4|CNKR3_HUMAN (Connector enhancer of kinase suppressor of ras 3 OS=Homo sapiens OX=9606 GN=CNKSR3 PE=1 SV=1)

HSP 1 Score: 110.923 bits (276), Expect = 7.867e-24
Identity = 79/327 (24.16%), Postives = 156/327 (47.71%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ--YIVSDKGDQKFADVK---GISN-MIRYRTQSFIDSCRDSLYLTPCI--IDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            +  WS  +V  W RG+  CL +Y+  F++   +G  L  +S  DL+ +G  +IGH  ++L++V +L    + +  + ++N++ ++  ++ +L NY+                R SP YD      N+ +  P +           ++SV++L  +    L+WL++  F  +++    K  ++     L    Q    V++  D+    VK   GI +  IR  T   +  C        C+  +    I   E +  G+ +K+ +  LH+I     NSPA    K+  GDE++++N Q ++GW  +++++++R +P  + L L+K+P
Sbjct:    4 VTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYIS-------------SRRKSPAYDG-----NTSRKAPNEF----------LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCA-------CLEEVHLPNIKPGEGL--GMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRP 293
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. UniProt/SwissProt
Match: sp|G9CGD6|CNIPF_HUMAN (CNK3/IPCEF1 fusion protein OS=Homo sapiens OX=9606 GN=CNK3/IPCEF1 PE=1 SV=1)

HSP 1 Score: 111.694 bits (278), Expect = 1.374e-23
Identity = 77/325 (23.69%), Postives = 154/325 (47.38%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ--YIVSDKGDQKFADVK---GISN-MIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            +  WS  +V  W RG+  CL +Y+  F++   +G  L  +S  DL+ +G  +IGH  ++L++V +L    + +  + ++N++ ++  ++ +L NY+                R SP YD      N+ +  P +           ++SV++L  +    L+WL++  F  +++    K  ++     L    Q    V++  D+    VK   GI +  IR  T   +  C        C+ +    +       G+ +K+ +  LH+I     NSPA    K+  GDE++++N Q ++GW  +++++++R +P  + L L+K+P
Sbjct:    4 VTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYIS-------------SRRKSPAYDG-----NTSRKAPNEF----------LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCA-------CLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRP 293
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. UniProt/SwissProt
Match: sp|G5EEW9|CNKR_CAEEL (Connector enhancer of kinase suppressor of ras OS=Caenorhabditis elegans OX=6239 GN=cnk-1 PE=2 SV=1)

HSP 1 Score: 94.7449 bits (234), Expect = 2.275e-18
Identity = 79/331 (23.87%), Postives = 152/331 (45.92%), Query Frame = 2 
Query:   26 FLYNINNWSGDEVESWIRGISPCLSEYLPFDKPSC-DGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNK------PNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHK-TENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRS-HPRKLSLRLRKKP 991
            F   +  W G E+  WI G+   ++ YL   + +   G+ L  L    LK +G   +G    +  +V +L+   H+  +E LQ +  +V  +   +   +   +R+ E                             +  EI +I   + ++VL+L       + WL++      P FI+V   V   +  L  L+ +N   + +  + G Q    +  +S  + Y  Q  +D C D L L  C I++  + + ++NI +G+N+++ +  +H+I  I   SPA +  K++ GDEIL IN + ++GW   SV++++ +    +LSL ++++P
Sbjct:   49 FARCVEQWKGKEIARWIEGLGDQMNPYLGMIRDNIKSGKQLEALDDDSLKKIGISALGARKTIFQAVSLLLYFCHESEHENLQRLAQQVKTSCLYVERTMTSAMRMREKA--------------------------IRRSEIVNILNSVSNAVLQLAEHTKRFVFWLDRTPFDEEPEFINVRNSVSSFMWNL--LRNVNVQPKALF-ETGSQ----IVRMSKELAYECQKIVD-CDDPLILYACFIESALLRRRSDNINWGLNIQSSYRGVHVISEIKEGSPADACTKIDAGDEILMINGRTVVGWDLTSVVQQVGALDVLELSLIVKRRP 345
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. TrEMBL
Match: A0A5K4F122 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 220.32 bits (560), Expect = 2.868e-55
Identity = 127/371 (34.23%), Postives = 206/371 (55.53%), Query Frame = 2 
Query:   44 NWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESIN--SGGRRNR---NMPQNAGNSGQLRGG-VLTR-PSKRINQAGLLGS 1132
            +W+  +V SW+ G+   +  YL  F   +  G+WL++L+   L   G QKIGH +I+L+ V+ L  +    +NETLQ+V+ RVS + T +I  ++  + + +      Q+  SP              YPG L +IQ     I+S +L L ++I  + SWL +P F  + E+V  +  L+++    NR +Q  +S + ++ F ++      +R R +  + +C DS+ LTPC I+ VQI K ++  FG N ++   N+H+I S+   SPA+S GK+ +GDE++E+N QI+IGW H  V + +R   + +SLRLRK+P H N+ I     GRR+R   N    AG+  Q RG  + TR P +R+   G L +
Sbjct:   12 SWTTTQVISWLSGLDDAIEPYLSAFSAKNISGKWLSSLTADVLDKYGVQKIGHQMIILEKVKQLQYQFSSFDNETLQSVLLRVSRSCTCIITAINSLMAITKR-----QDADSP--------------YPGILSDIQGAASYILSCILNLMSTIANAASWLERPPFSLLPEMVVFRQFLVENAIITNRLSQQAISAQCNEHFKEIIDYIEPMRIRVEDVLQNCGDSILLTPCGIEMVQIRKLDSADFGFNFRSTINNIHVIVSVQDESPAFSTGKVTKGDEVIEVNEQIVIGWLHYRVADLMRHSSQHISLRLRKRPSHSNDFIGFPGAGRRHRLIVNQIPPAGSLSQTRGAYIFTRNPKRRLPLTGPLSA 363
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. TrEMBL
Match: A0A4Z2DA01 (Connector enhancer of kinase suppressor of ras 2 OS=Schistosoma japonicum OX=6182 GN=EWB00_003068 PE=4 SV=1)

HSP 1 Score: 217.624 bits (553), Expect = 1.855e-54
Identity = 124/371 (33.42%), Postives = 204/371 (54.99%), Query Frame = 2 
Query:   44 NWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESIN--SGGRRNR---NMPQNAGNSGQLRGG-VLTR-PSKRINQAGLLGS 1132
            +W+  +V SW+ G+   L  YLP F   +  G+WL+ L+   L   G QK+GH +I+++ V+ L  +    +NETLQ+V+ RVS   T ++  ++  + + +      Q+  SP              YPG L +IQ     I+  +L L ++I  + SWL +P F  + ++   +  L+++    NR +Q  +S + +Q F ++      +R R +  + +C DS+ LTPC I+TVQI K ++  FG N ++   N+H+I S+   SPA+S GK+ +GDE++E+N QI+IGW H  V + +R   + +SLRLRK+P H N+ I     GRR+R   N    AG+  Q+RG  +  R P +R+   G L +
Sbjct:   12 SWTTAQVISWLSGLDDALEPYLPTFIAKNISGKWLSCLTADVLGKYGVQKVGHQMIIMEKVKQLQYQFSSFDNETLQSVLLRVSRACTCIVTAINSLMAITKR-----QDADSP--------------YPGILSDIQEAVTYILGCILNLMSTIGSAASWLERPPFSLLPDMTVFRQFLVENAIITNRLSQQAISTQCNQHFREIIDYIEPMRSRVEDVLQNCSDSIILTPCGIETVQIRKLDSADFGFNFRSTINNIHVIVSVQNESPAFSTGKVSKGDEVIEVNEQIVIGWLHYRVADLMRHSSQHISLRLRKRPCHSNDFIGFPGAGRRHRLVVNQIPPAGSLSQIRGAYIFARNPKRRLPLTGPLSA 363

HSP 2 Score: 62.3882 bits (150), Expect = 6.284e-6
Identity = 33/118 (27.97%), Postives = 59/118 (50.00%), Query Frame = 2 
Query: 1775 LFMAKKSSGSKETEFNRQFDSNVVGQG-CDGFIYMKRLHHLRNSYVKTWCSFQNKILSVFENKNGKHFED-INIEICHVTPLIKSGNNSFYFEVRHEWSTYHFGTKDAKEYNKWINTL 2122
            +F  K   GSK+    R+     +GQG C G++++K+ + L + YVK WC ++N     + N   +  E  I +    +TP +   +  F F V ++W  + F +    + +KW+N L
Sbjct:  597 VFFLKHGLGSKKP--TRRISCKDLGQGDCQGWLWLKKTNALTSKYVKRWCVYKNSTFYYYRNPEDESAEGLILLHGFTITPAVSVKSGKFAFSVFNDWVRFVFASDSELDRSKWMNKL 712
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. TrEMBL
Match: A0A1S8X041 (PH domain protein OS=Opisthorchis viverrini OX=6198 GN=X801_04041 PE=4 SV=1)

HSP 1 Score: 201.445 bits (511), Expect = 2.503e-49
Identity = 107/346 (30.92%), Postives = 192/346 (55.49%), Query Frame = 2 
Query:   44 NWSGDEVESWIR--------GISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNE--SINSGGRRNRNMPQ 1048
            NWS D+V SW+R        G+   + +Y+  F     +G+WL  ++  +L  +G  K+GH +I+LD +R L  +    +NETLQ V++RV     S++  V+ +  + E  +         F D +     +  +YPG LD++Q     I++ VL L  ++  +  WL++P F ++ +++ ++  L++    +N   Q  ++++    F +V+     +  R  + I  C DS+ LTPC ++ VQ+ K +   FG N+++   N+H I  +   SPA+  GK+  GDE++E+N+Q++IGW H+ V + +R +P+++SLRLRK+PMH  +      GGRR+R + Q
Sbjct:   13 NWSTDQVISWLRAKLTLLPIGLDGFVEDYVNNFKAKGVNGKWLNCVTPGELIRLGITKVGHQMIILDRIRQLQAQYCAFDNETLQMVLFRVCRACVSIVAAVNAHTSIVERQD---------FRDPD-----ADAVYPGILDDLQDAVTYILNCVLTLMTAVWNAAFWLDRPPFHTLPDMISLRKFLIERALLVNNAAQLAIANQLPTHFKEVQTHVESVGDRVDAVIQGCNDSIMLTPCGMELVQLRKADAAEFGFNLESTQTNVHWIAFVQQESPAFCSGKVTRGDEVVEVNDQVVIGWQHRRVADLMRLYPKRISLRLRKRPMHATDFSGFPGGGRRHRVVAQ 344
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. TrEMBL
Match: A0A074ZMX3 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_07713 PE=4 SV=1)

HSP 1 Score: 192.2 bits (487), Expect = 2.528e-46
Identity = 97/314 (30.89%), Postives = 176/314 (56.05%), Query Frame = 2 
Query:  113 FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNE--SINSGGRRNRNMPQ 1048
            F     +G+WL  ++  +L  +G  K+GH +I+LD +R L  +    +NETLQ V++RV     S++  V+ +  + E  +         F D +     +  +YPG LD++Q     I++ VL L  ++  +  WL++P F ++ +++ ++  L++    +N   Q  ++++    F +V+     +  R  + I  C DS+ LTPC ++ VQ+ K +   FG N+++   N+H I  +   SPA+  GK+  GDE++E+N+Q++IGW H+ V + +R +P+++SLRLRK+PMH  +      GGRR+R + Q
Sbjct:   25 FKAKGVNGKWLNCVTPGELIRLGITKVGHQMIILDRIRQLQAQYCAFDNETLQMVLFRVCRACVSIVAAVNAHTSIVERQD---------FRDPD-----ADAVYPGILDDLQDAVTYILNCVLTLMTAVWNAAFWLDRPPFHTLPDMISLRKFLIERALLVNNAAQLAIANQLPTHFKEVQTHVESVGDRVDAVIQGCNDSIMLTPCGMELVQLRKADAAEFGFNLESTQTNVHWIAFVQQESPAFCSGKVTRGDEVVEVNDQVVIGWQHRRVADLMRLYPKRISLRLRKRPMHATDFSGFPGGGRRHRVVAQ 324
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. TrEMBL
Match: A0A419Q186 (LINE-1 retrotransposable element ORF2 protein OS=Clonorchis sinensis OX=79923 GN=Pol PE=4 SV=1)

HSP 1 Score: 181.03 bits (458), Expect = 2.649e-42
Identity = 96/314 (30.57%), Postives = 176/314 (56.05%), Query Frame = 2 
Query:  113 FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNE--SINSGGRRNRNMPQ 1048
            F     +G+WL  ++  +L  +G  K+GH +I+LD +R L  +    ++ETLQ V++RV     S++  V+ +  + E      Q+   P         ++  +YPG LD++Q     I++ VL L  ++  +  WL++P F ++ +++ ++  L++    +N   Q  ++++    F +V+     +  R  + I  C DS+ LTPC ++ VQ+ K +   FG N+++   N+H I  +   SPA+  GK+  GDE++E+N+Q++IGW H+ V + +R +P+++SLRLRK+PMH  +      GGRR+R + Q
Sbjct: 1062 FRAKGVNGKWLNCVTPGELIRLGITKVGHQMIILDRIRQLQTQYCAFDSETLQVVLFRVCRACVSIVAAVNAHTSIVER-----QDFRDP---------DADAVYPGILDDLQDAVTYILNCVLTLMTAVWNAAFWLDRPPFHTLPDMIALRKFLIERALLVNNAAQLAIANQLPTHFKEVQTHVESVGDRVDAVIQGCNDSIMLTPCGMELVQLRKADAAEFGFNLESTQTNVHWIAFVQQESPAFCSGKVTRGDEVVEVNDQVVIGWQHRRVADLMRLYPKRISLRLRKRPMHATDFSGFPGGGRRHRVVAQ 1361
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Cavefish
Match: si:ch211-26b3.4 (connector enhancer of kinase suppressor of ras 2-like [Source:NCBI gene;Acc:103026362])

HSP 1 Score: 99.3673 bits (246), Expect = 1.172e-20
Identity = 75/327 (22.94%), Postives = 156/327 (47.71%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQY--IVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKT-ENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  I+ WS  +V  W++G+  CL +Y+  F++    G  L +++  +L+ +G  +IGH  ++L++V +L    + +  E L+++ ++++ +A +L N++    R      H+   R+S    N+                        ++SV+ L  +    L+WL++  F+SV+E   +K  ++     L    Q    V +  ++     K +S +  +     I    DSL      ++ V +     N   G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P
Sbjct:    3 LVMEPISKWSPRQVLEWMKGLDDCLLQYVRTFERERISGEQLLHITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLRSLSHKLNASAKNLQNFITGRRRGG----HY-DGRVSRRLPND-----------------------FLTSVVDLIGAAKNLLAWLDRSPFVSVTEYSVLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLSGICEH----IISLSSDSLVSQSAHLEVVHLTNVMPNEGLGMYIKSTYDGLHVITGTTENSPADLCKKIHAGDEVIQVNHQTVVGWQLKNLVNSLREDPSGVILTLKKRP 297
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Cavefish
Match: si:ch211-26b3.4 (connector enhancer of kinase suppressor of ras 2-like [Source:NCBI gene;Acc:103026362])

HSP 1 Score: 99.3673 bits (246), Expect = 1.216e-20
Identity = 75/330 (22.73%), Postives = 157/330 (47.58%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYL-PFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQY--IVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKT-ENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHV 1000
            + +  I+ WS  +V  W++G+  CL +Y+  F++    G  L +++  +L+ +G  +IGH  ++L++V +L    + +  E L+++ ++++ +A +L N++    R      H+   R+S    N+                        ++SV+ L  +    L+WL++  F+SV+E   +K  ++     L    Q    V +  ++     K +S +  +     I    DSL      ++ V +     N   G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P + 
Sbjct:    3 LVMEPISKWSPRQVLEWMKGLDDCLLQYVRTFERERISGEQLLHITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLRSLSHKLNASAKNLQNFITGRRRGG----HY-DGRVSRRLPND-----------------------FLTSVVDLIGAAKNLLAWLDRSPFVSVTEYSVLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLSGICEH----IISLSSDSLVSQSAHLEVVHLTNVMPNEGLGMYIKSTYDGLHVITGTTENSPADLCKKIHAGDEVIQVNHQTVVGWQLKNLVNSLREDPSGVILTLKKRPQNA 300
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Cavefish
Match: ENSAMXT00000050121.1 (pep primary_assembly:Astyanax_mexicanus-2.0:24:20833127:20883243:1 gene:ENSAMXG00000029522.1 transcript:ENSAMXT00000050121.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 84.3445 bits (207), Expect = 1.125e-16
Identity = 76/322 (23.60%), Postives = 151/322 (46.89%), Query Frame = 2 
Query:   80 GISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADV----------KGI-SNMIRY---RTQ---SFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            G+  CL +Y+  F++    G  L +++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++             L  R    YD       S++L P             ++SV+ L  +    L+WL++  F+SV+E   +K    +++ +L      IV  K    F+ V          +G+ SN +     R Q     +  C  +  L+P        H+    + G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P
Sbjct:    8 GLDDCLQQYIKNFEREKITGEQLLHITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLRTLSHKLNASAKNLQNFI-------------LGRRRGGHYDGRA----SRRL-PNDF----------LTSVVDLIGAAKNLLAWLDRSPFVSVTEYSLLK----NNIVQLCLELTTIVQQKVCPSFSLVLYTLRSSLFCRGVLSNSMELDETRLQYISCILCLCNPTFLLSPS-------HQCTRHLQGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPNGVILTLKKRP 290
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Cavefish
Match: cnksr1 (connector enhancer of kinase suppressor of Ras 1 [Source:NCBI gene;Acc:103024930])

HSP 1 Score: 81.2629 bits (199), Expect = 3.624e-15
Identity = 83/365 (22.74%), Postives = 153/365 (41.92%), Query Frame = 2 
Query:   38 INNWSGDEVESWIRGISPCLSEYLPFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKR--LNRYTQY--------IVSDKGDQKFADVKGISNM--IRYRTQSFIDSCRDSLYLTP--CIIDTVQIHKTENI------VFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHV--NESINSGGRRNRNMPQNAGNSG 1066
            +++WS   V  W RG+   L +Y  F++    G  L  LS + L+ +G  KIGH  ++L++V  L    +    ETL++V  ++   A SL   V    R+N              YD +  T    QL P      Q +++++                           +L+    GL   L+R   N +T Y        + ++ G     DV        I   ++  +  C + L   P   +  + Q+H  + +        GI + +   + H I      SPA    K+  GDE++++N+QI++GW  ++++ +++ +P  ++L L++ P+ +   E   S  R N++  Q +  SG
Sbjct:    4 VSSWSCARVSKWFRGLDASLQQYT-FEEWKLSGADLLQLSSNRLEKLGVHKIGHQELILEAVEKLCSLTYGACGETLRSVTEKLRAVAHSLQMGVQGRWRVNT-------------YDGQSNT----QLSP------QVLQVVV---------------------------DLITASKGLFYMLERYQCNEFTGYSSNKNIITLCTELGTIVHKDVTVFEKEKDIIATSRQLVAICDEILTSVPEAVLAHSAQLHNVDLVPISPGEQLGIEITSTASSHHFISGTAAESPAEFSEKILAGDEVIQVNDQIVVGWSRKNLVAKLQENPNGVTLLLKRVPVSLRRKEKTESLTRSNKDKHQESVVSG 317
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Cavefish
Match: cnksr2a (connector enhancer of kinase suppressor of Ras 2a [Source:ZFIN;Acc:ZDB-GENE-060228-5])

HSP 1 Score: 76.6406 bits (187), Expect = 8.780e-14
Identity = 63/301 (20.93%), Postives = 133/301 (44.19%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIII 913
            + +  ++ WS  +V  W++G+  CL +Y+  F++    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++                R S  YD                   + +    ++SV+ L  +    L+WL++  F +V++    +  ++     L    Q +         + VK +S +  +     I    D L      ++ VQ   I  TE +  G+ +K+ +  LH+I      SPA    K+  GDE++++N+Q + 
Sbjct:    3 LVMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKVGGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFI-------------TGRRRSGHYDGRT---------------TRKLPNDFLTSVVDLIAAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQV-------SHSVVKTLSGVCDH----IISLSSDPLVSQSAHLEVVQLANIKPTEGL--GMYIKSTYDGLHVITGTTEGSPADRCKKIHAGDEVIQVNHQTVT 262
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Medaka
Match: si:ch211-26b3.4 (connector enhancer of kinase suppressor of ras 2 [Source:NCBI gene;Acc:101174439])

HSP 1 Score: 105.531 bits (262), Expect = 1.388e-22
Identity = 77/325 (23.69%), Postives = 154/325 (47.38%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHK-TENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  I+ W+  +V  W++G+  CL +Y+  F++    G  L +++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++             L  R    YD       S++L P             ++SV+ L  +    L+WL++  F SV+E   +K  ++     L    Q ++S         + GI + I       I    DSL      ++ V +     N   G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P
Sbjct:    3 LVMEPISKWTPKQVLDWMKGLDDCLQQYIKSFEREQMGGEQLLHITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLRTLSHKLNASAKNLQNFI-------------LGRRRGGHYDGR----ASRRL-PNDF----------LTSVVDLIGAAKNLLAWLDRSPFASVTEYSLLKNNIVQLCLELTTIVQQVLSHTYTSNCKTLAGICDHI-------ISLSSDSLVSQSAHLEVVHLTSIMPNEGLGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPCGVILTLKKRP 292
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Medaka
Match: si:ch211-26b3.4 (connector enhancer of kinase suppressor of ras 2 [Source:NCBI gene;Acc:101174439])

HSP 1 Score: 99.3673 bits (246), Expect = 1.003e-20
Identity = 78/330 (23.64%), Postives = 154/330 (46.67%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHK-TENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  I+ W+  +V  W++G+  CL +Y+  F++    G  L +++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++             L  R    YD       S++L P             ++SV+ L  +    L+WL++  F SV+E   +K  ++     L    Q     Y   +K       + GI + I       I    DSL      ++ V +     N   G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P
Sbjct:    3 LVMEPISKWTPKQVLDWMKGLDDCLQQYIKSFEREQMGGEQLLHITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLRTLSHKLNASAKNLQNFI-------------LGRRRGGHYDGR----ASRRL-PNDF----------LTSVVDLIGAAKNLLAWLDRSPFASVTEYSLLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLAGICDHI-------ISLSSDSLVSQSAHLEVVHLTSIMPNEGLGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPCGVILTLKKRP 297
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Medaka
Match: si:ch211-26b3.4 (connector enhancer of kinase suppressor of ras 2 [Source:NCBI gene;Acc:101174439])

HSP 1 Score: 99.3673 bits (246), Expect = 1.075e-20
Identity = 78/330 (23.64%), Postives = 154/330 (46.67%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ-----YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHK-TENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKP 991
            + +  I+ W+  +V  W++G+  CL +Y+  F++    G  L +++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + ++++ +A +L N++             L  R    YD       S++L P             ++SV+ L  +    L+WL++  F SV+E   +K  ++     L    Q     Y   +K       + GI + I       I    DSL      ++ V +     N   G+ +K+ +  LH+I     NSPA    K+  GDE++++N+Q ++GW  ++++  +R  P  + L L+K+P
Sbjct:    3 LVMEPISKWTPKQVLDWMKGLDDCLQQYIKSFEREQMGGEQLLHITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLRTLSHKLNASAKNLQNFI-------------LGRRRGGHYDGR----ASRRL-PNDF----------LTSVVDLIGAAKNLLAWLDRSPFASVTEYSLLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLAGICDHI-------ISLSSDSLVSQSAHLEVVHLTSIMPNEGLGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPCGVILTLKKRP 297
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Medaka
Match: ENSORLT00000034012.1 (connector enhancer of kinase suppressor of ras 3 [Source:NCBI gene;Acc:101165528])

HSP 1 Score: 87.8113 bits (216), Expect = 1.784e-17
Identity = 83/381 (21.78%), Postives = 161/381 (42.26%), Query Frame = 2 
Query:   29 LYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ--YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRN-RNMP---QNAGNSGQLRGGVLTRPSKRINQAGLLGSVSTPAT 1150
            + +++ WS  +V  W+ G+   L +YLP F +   DG  L  +S  +L  +G  ++GH  ++L++V +L      +  + L+ ++  +     +LI+ V              Q R +P Y ++    NS Q                +++V++L  +    L+WL++    S  +   +K  ++     L    Q    V D  ++     + ++++     Q   D  +  + L   ++ T  I   E +  GI +K+ +   H+I     NSPA    ++  GDE+++IN Q ++GW  + +++  R+    L L L+K+P   +        RN R  P   Q +  +       L  P+    +      VS  AT
Sbjct:    1 MESVSAWSPQQVLDWMTGLDDSLQQYLPSFQQQQVDGEKLLRMSHQELLCLGVDRVGHQELVLEAVDLLCSLSCGVELDNLKTLVGTMRTAHQNLISAVS-------------QRRRNPAYQHK----NSHQ-----------PSSPFLTAVMQLIGAAKKLLAWLDRSPLTSPKDFTSIKSRIIQLCLELTSTVQKDCTVYDMEEKILEVSQALNSVCEKTVQVTSDPSKGEVSLLEEVLIT-DIKPGEGL--GIYIKSTYDGHHVITGTTENSPADQTQRIHAGDEVIQINRQTVVGWQLKHLVKTFRTDSSSLVLVLKKRPPGTSSRFAPAPLRNLRWRPLLVQTSQGAAGFHSCALPEPTDPPGKTDREAEVSAAAT 350
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Medaka
Match: cnksr2b (connector enhancer of kinase suppressor of ras 2 [Source:NCBI gene;Acc:101167472])

HSP 1 Score: 88.5817 bits (218), Expect = 2.395e-17
Identity = 84/390 (21.54%), Postives = 170/390 (43.59%), Query Frame = 2 
Query:   23 IFLYNINNWSGDEVESWIRGISPCLSEYLP-FDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFI---SVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRD--SLYLTPCI-----IDTVQ---IHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNM-----------PQNAGNSGQLRGGVLTRPSKRINQA 1117
            + +  ++ WS  +V  W++G+  CL +Y+  F+K    G  L  ++  +L+ +G  +IGH  ++L++V +L    + +  E L+ + +++S +A +L N++                R S  YD                     +    ++SV+ L  +    L+WL++ +F      + + D  +   + ++     T  +  D        V    N I    ++  + C    SL   P +     ++ VQ   I  TE +  G+ +K+ +  LH+I      S A    K+  GDE++++N+Q ++GW  ++++  +R  P  ++L L+K+P     ++ S     +NM           PQ+  +S       L+ PS+R + A
Sbjct:    3 LIMEPVSKWSPSQVVDWMKGLDDCLQQYIKTFEKEKVGGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLSASAKNLQNFITG-------------RRRSGHYDGR---------------TTHKLPNDFLTSVVDLIAAAKSLLAWLDRCSFFFRSPFAAVADYSVTRNNVIQLCLELTTIVQQD------CSVYETENKILNVCKTLSEVCDQIISLSSDPMVSQSAHLEVVQLANIKSTEGL--GMYIKSTYDGLHVITGTTEGSLADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNLLRGDPAGVTLTLKKRP---QSTLTSTPALLKNMRWKPLALQPIFPQSPSSSVATPTSTLSTPSRRSSCA 353
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Planmine SMEST
Match: SMESG000044449.1 (SMESG000044449.1)

HSP 1 Score: 1079.7 bits (2791), Expect = 0.000e+0
Identity = 527/527 (100.00%), Postives = 527/527 (100.00%), Query Frame = 2 
Query:   14 MSEIFLYNINNWSGDEVESWIRGISPCLSEYLPFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNMPQNAGNSGQLRGGVLTRPSKRINQAGLLGSVSTPATPVLLSKNVHINAGNSELLKQANHDIVNEMLRKLTLEHHNLDINKNEELGSESEYSAADASPYVIRHKIKPVKETKLQDYDNIGNPFHKPIADTFTVLSEEDDAKSDFGSGEIYPRRSLTNENDSMDELLGPKSEKRQTDETFTSAVSP 1594
            MSEIFLYNINNWSGDEVESWIRGISPCLSEYLPFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNMPQNAGNSGQLRGGVLTRPSKRINQAGLLGSVSTPATPVLLSKNVHINAGNSELLKQANHDIVNEMLRKLTLEHHNLDINKNEELGSESEYSAADASPYVIRHKIKPVKETKLQDYDNIGNPFHKPIADTFTVLSEEDDAKSDFGSGEIYPRRSLTNENDSMDELLGPKSEKRQTDETFTSAVSP
Sbjct:    1 MSEIFLYNINNWSGDEVESWIRGISPCLSEYLPFDKPSCDGRWLTNLSLSDLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLINYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKMIIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQYIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHKTENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIIIGWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNMPQNAGNSGQLRGGVLTRPSKRINQAGLLGSVSTPATPVLLSKNVHINAGNSELLKQANHDIVNEMLRKLTLEHHNLDINKNEELGSESEYSAADASPYVIRHKIKPVKETKLQDYDNIGNPFHKPIADTFTVLSEEDDAKSDFGSGEIYPRRSLTNENDSMDELLGPKSEKRQTDETFTSAVSP 527
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Planmine SMEST
Match: SMESG000044448.1 (SMESG000044448.1)

HSP 1 Score: 471.855 bits (1213), Expect = 1.768e-159
Identity = 229/243 (94.24%), Postives = 233/243 (95.88%), Query Frame = 2 
Query: 1781 MAKKSSGSKETEFNRQFDSNVVGQGCDGFIYMKRLHHLRNSYVKTWCSFQNKILSVFENKNGKHFEDINIEICHVTPLIKSGNNSFYFEVRHEWSTYHFGTKDAKEYNKWINTLQSESLKSKPESDILHRNALFKSYSREESISQFESTSSVFISDSNLSKPLENGDIYDEVTSPGVGNFSRNSPKGSIHSDNVFDNEKRGENDDGRNDKSKQNSESLVMDKFKFMADLERQIRASFVLYISI 2509
            MAKKSSGSKETEFNRQFDSNVVGQGCDG IYMKRLHHLRNSYVKTWCSFQNKILSVFENKNGKHFEDINIEICHVTPLIKSGNNSFYFEVRHEWSTYHFGTKDA EYNKWINTLQSESLKSKPES+ILHRNALFKSYSREESISQFESTSSVFISDSNLSKPLENGDIYDEVTSP +GNFSRNSPKGSIHSDNVFDNEKRGEND+GRNDKSKQNSESLVMDKFKFMADLERQIR   +    I
Sbjct:    1 MAKKSSGSKETEFNRQFDSNVVGQGCDGLIYMKRLHHLRNSYVKTWCSFQNKILSVFENKNGKHFEDINIEICHVTPLIKSGNNSFYFEVRHEWSTYHFGTKDANEYNKWINTLQSESLKSKPESNILHRNALFKSYSREESISQFESTSSVFISDSNLSKPLENGDIYDEVTSPEMGNFSRNSPKGSIHSDNVFDNEKRGENDNGRNDKSKQNSESLVMDKFKFMADLERQIRDKTLFVTQI 243
[Close]
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Planmine SMEST
Match: SMESG000044448.1 (SMESG000044448.1)

HSP 1 Score: 434.106 bits (1115), Expect = 1.367e-145
Identity = 211/217 (97.24%), Postives = 214/217 (98.62%), Query Frame = 2 
Query: 1781 MAKKSSGSKETEFNRQFDSNVVGQGCDGFIYMKRLHHLRNSYVKTWCSFQNKILSVFENKNGKHFEDINIEICHVTPLIKSGNNSFYFEVRHEWSTYHFGTKDAKEYNKWINTLQSESLKSKPESDILHRNALFKSYSREESISQFESTSSVFISDSNLSKPLENGDIYDEVTSPGVGNFSRNSPKGSIHSDNVFDNEKRGENDDGRNDKSKQNSES 2431
            MAKKSSGSKETEFNRQFDSNVVGQGCDG IYMKRLHHLRNSYVKTWCSFQNKILSVFENKNGKHFEDINIEICHVTPLIKSGNNSFYFEVRHEWSTYHFGTKDA EYNKWINTLQSESLKSKPES+ILHRNALFKSYSREESISQFESTSSVFISDSNLSKPLENGDIYDEVTSP +GNFSRNSPKGSIHSDNVFDNEKRGEND+GRNDKSKQNSES
Sbjct:    1 MAKKSSGSKETEFNRQFDSNVVGQGCDGLIYMKRLHHLRNSYVKTWCSFQNKILSVFENKNGKHFEDINIEICHVTPLIKSGNNSFYFEVRHEWSTYHFGTKDANEYNKWINTLQSESLKSKPESNILHRNALFKSYSREESISQFESTSSVFISDSNLSKPLENGDIYDEVTSPEMGNFSRNSPKGSIHSDNVFDNEKRGENDNGRNDKSKQNSES 217
The following BLAST results are available for this feature:
BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CNKSR31.638e-2424.16CNKSR family member 3 [Source:HGNC Symbol;Acc:HGNC... [more]
AL357075.42.861e-2423.69CNK3/IPCEF1 fusion protein [Source:UniProtKB/Swis... [more]
CNKSR24.269e-1921.56connector enhancer of kinase suppressor of Ras 2 [... [more]
CNKSR24.588e-1921.87connector enhancer of kinase suppressor of Ras 2 [... [more]
CNKSR25.118e-1921.56connector enhancer of kinase suppressor of Ras 2 [... [more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cnk-11.788e-1923.87Connector enhancer of kinase suppressor of ras [S... [more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cnk5.547e-1434.65gene:FBgn0286070 transcript:FBtr0086962[more]
cnk5.547e-1434.65gene:FBgn0286070 transcript:FBtr0340214[more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:ch211-26b3.41.009e-2023.03si:ch211-26b3.4 [Source:ZFIN;Acc:ZDB-GENE-081104-6... [more]
cnksr2a5.495e-2021.69connector enhancer of kinase suppressor of Ras 2a ... [more]
cnksr2a1.574e-1921.69connector enhancer of kinase suppressor of Ras 2a ... [more]
cnksr2b1.097e-1821.08connector enhancer of kinase suppressor of Ras 2b ... [more]
cnksr38.386e-1821.04cnksr family member 3 [Source:ZFIN;Acc:ZDB-GENE-08... [more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
adamts103.331e-2124.02ADAM metallopeptidase with thrombospondin type 1 m... [more]
mul1a4.415e-1921.30mitochondrial E3 ubiquitin protein ligase 1a [Sour... [more]
mul1a6.111e-1921.30mitochondrial E3 ubiquitin protein ligase 1a [Sour... [more]
mul1a8.030e-1922.46mitochondrial E3 ubiquitin protein ligase 1a [Sour... [more]
mul1a1.342e-1621.84mitochondrial E3 ubiquitin protein ligase 1a [Sour... [more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Cnksr32.540e-2523.55Cnksr family member 3 [Source:MGI Symbol;Acc:MGI:2... [more]
Cnksr23.509e-1921.56connector enhancer of kinase suppressor of Ras 2 [... [more]
Cnksr24.734e-1921.56connector enhancer of kinase suppressor of Ras 2 [... [more]
Cnksr11.997e-1420.90connector enhancer of kinase suppressor of Ras 1 [... [more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8BMA3|CNKR3_MOUSE1.777e-2423.55Connector enhancer of kinase suppressor of ras 3 O... [more]
sp|Q5SGD7|CNKR3_RAT3.286e-2424.16Connector enhancer of kinase suppressor of ras 3 O... [more]
sp|Q6P9H4|CNKR3_HUMAN7.867e-2424.16Connector enhancer of kinase suppressor of ras 3 O... [more]
sp|G9CGD6|CNIPF_HUMAN1.374e-2323.69CNK3/IPCEF1 fusion protein OS=Homo sapiens OX=9606... [more]
sp|G5EEW9|CNKR_CAEEL2.275e-1823.87Connector enhancer of kinase suppressor of ras OS=... [more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K4F1222.868e-5534.23Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A4Z2DA011.855e-5433.42Connector enhancer of kinase suppressor of ras 2 O... [more]
A0A1S8X0412.503e-4930.92PH domain protein OS=Opisthorchis viverrini OX=619... [more]
A0A074ZMX32.528e-4630.89Uncharacterized protein OS=Opisthorchis viverrini ... [more]
A0A419Q1862.649e-4230.57LINE-1 retrotransposable element ORF2 protein OS=C... [more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:ch211-26b3.41.172e-2022.94connector enhancer of kinase suppressor of ras 2-l... [more]
si:ch211-26b3.41.216e-2022.73connector enhancer of kinase suppressor of ras 2-l... [more]
ENSAMXT00000050121.11.125e-1623.60pep primary_assembly:Astyanax_mexicanus-2.0:24:208... [more]
cnksr13.624e-1522.74connector enhancer of kinase suppressor of Ras 1 [... [more]
cnksr2a8.780e-1420.93connector enhancer of kinase suppressor of Ras 2a ... [more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:ch211-26b3.41.388e-2223.69connector enhancer of kinase suppressor of ras 2 [... [more]
si:ch211-26b3.41.003e-2023.64connector enhancer of kinase suppressor of ras 2 [... [more]
si:ch211-26b3.41.075e-2023.64connector enhancer of kinase suppressor of ras 2 [... [more]
ENSORLT00000034012.11.784e-1721.78connector enhancer of kinase suppressor of ras 3 [... [more]
cnksr2b2.395e-1721.54connector enhancer of kinase suppressor of ras 2 [... [more]
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BLAST of Connector enhancer of kinase suppressor of ras 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000044449.10.000e+0100.00SMESG000044449.1[more]
SMESG000044448.11.768e-15994.24SMESG000044448.1[more]
SMESG000044448.11.367e-14597.24SMESG000044448.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008165 ID=SMED30008165|Name=Connector enhancer of kinase suppressor of ras 2|organism=Schmidtea mediterranea sexual|type=transcript|length=3133bp
TCTGTAAATTTAAATGTCTGAAATATTTTTGTATAATATTAATAATTGGA
GCGGTGACGAAGTAGAATCATGGATTAGAGGTATAAGTCCTTGTCTTAGC
GAATATTTACCATTTGATAAACCATCATGTGATGGAAGATGGCTGACTAA
TTTGTCTTTAAGTGATTTGAAAAGCGTTGGATTTCAAAAGATTGGACATG
CTATAATTCTTTTAGATTCAGTCCGAATATTGATTGATGAATTACATCAA
ATGAATAATGAAACCTTGCAAAACGTAATTTATCGGGTATCATGTAACGC
TACATCTCTAATCAATTACGTTGATAAATATTTGAGACTTAATGAGTCAT
TGGAACATTTTCTACAAAATCGACTATCTCCATTTTATGATAATGAGGAT
CAAACTTTCAATAGTAAACAATTATATCCTGGTCAACTAGATGAAATACA
ATCAATCAAAATGATAATTATTTCTTCCGTTTTAAAACTTACTAATTCAA
TTCTAGTTTCGTTATCATGGCTTAACAAGCCAAATTTTATTTCTGTCTCT
GAATTGGTTGATATGAAGCTTGGGCTATTGGATGATCTCAAGAGACTCAA
TAGATATACTCAGTACATAGTCAGTGATAAAGGCGATCAGAAATTTGCAG
ACGTGAAAGGAATATCTAACATGATTCGCTACAGAACGCAATCATTTATC
GATTCTTGTAGAGATTCCCTATATTTAACACCGTGCATAATTGACACGGT
TCAGATTCATAAAACAGAAAATATAGTATTCGGTATCAACGTGAAAACTA
TATTTGGAAATTTGCATATTATTGAATCGATAGATATAAATTCTCCAGCT
TACAGTATTGGCAAACTTGAAGAAGGTGATGAAATTTTAGAAATCAACAA
TCAAATTATTATTGGTTGGTGTCATCAAAGTGTCATTGAAGAAATAAGAT
CCCATCCCCGTAAATTGTCCTTGAGACTGAGAAAGAAACCGATGCATGTT
AATGAGTCAATTAATTCTGGAGGGCGGCGAAATAGAAATATGCCACAAAA
TGCCGGAAATTCAGGCCAATTGAGAGGAGGAGTTCTGACAAGACCATCGA
AACGAATCAATCAAGCTGGGTTATTGGGAAGTGTCAGTACGCCAGCTACC
CCGGTTTTATTATCGAAAAATGTGCATATTAATGCTGGTAATAGTGAGTT
ACTAAAGCAGGCTAATCATGATATAGTAAATGAAATGCTCCGAAAACTTA
CCTTAGAACATCATAATTTAGATATTAATAAAAACGAGGAACTCGGCAGC
GAAAGTGAATATTCAGCGGCAGATGCATCACCTTATGTAATCAGGCATAA
AATCAAACCAGTAAAAGAAACTAAACTTCAAGATTACGACAATATTGGGA
ATCCCTTTCACAAACCTATAGCCGACACGTTTACTGTACTCTCTGAAGAA
GATGATGCCAAATCTGATTTTGGCAGCGGAGAAATTTATCCACGAAGATC
GCTGACAAATGAAAACGATTCCATGGATGAATTGCTTGGGCCAAAGTCAG
AAAAACGACAAACTGACGAAACATTCACTTCGGCTGTTAGTCCTTAACAA
GAAACACTTTTATGACTTTTTCTGTTCTCTTATGGTAGACCACTATGTGC
TGTGATCAATTATGAATCTGATCTGATAAGGTCATTGTATGTGTATGTGT
GTGATTGTATTTATGAACTTATCGACTTGATCATTTTCACAATCTACCAT
TGATACTGATTTATTTTGTTCTGTTTATTTATGGCGAAGAAAAGTTCTGG
ATCCAAGGAAACCGAATTCAACCGACAATTTGATTCCAATGTTGTTGGTC
AAGGCTGTGATGGTTTTATCTACATGAAGCGACTTCATCACTTGAGAAAT
TCCTATGTGAAGACCTGGTGTTCATTCCAAAATAAGATTCTCAGTGTTTT
TGAAAATAAAAATGGAAAGCACTTTGAAGATATCAACATTGAAATATGTC
ATGTAACTCCGTTAATAAAGTCAGGAAACAATAGCTTTTATTTTGAAGTT
CGGCATGAATGGTCGACCTATCATTTCGGAACGAAAGATGCCAAGGAATA
CAACAAATGGATTAATACCTTGCAAAGCGAATCATTAAAGAGCAAACCTG
AGAGTGATATCTTACACAGGAATGCTCTTTTCAAATCTTACAGTCGAGAA
GAAAGCATTTCTCAGTTTGAAAGTACAAGTTCCGTATTTATATCAGATTC
AAATTTATCAAAGCCTCTTGAAAATGGAGACATTTATGACGAGGTGACAT
CCCCCGGGGTTGGAAACTTTTCCCGTAATTCTCCTAAAGGCAGTATACAT
TCCGATAACGTTTTTGACAACGAGAAAAGAGGCGAGAATGACGACGGAAG
GAATGATAAATCAAAACAAAACTCTGAATCGTTAGTTATGGATAAATTTA
AATTTATGGCAGATTTAGAAAGACAAATTCGAGCAAGTTTTGTGTTGTAC
ATTTCAATTAAATGCGCCTGGCTCTTTAGTTGCGAGATTTGCTACACCAA
GTGCTTATATGTATATGTCATTCTTGTACTCTTTTACTCGGGGCCCGGCA
CAGGCAGGACTATAAATGGACAAACCCCAGAGCTCAGGATAGCTCTAGGA
AATTAAAATTAATATTTCTAGTGATTACTTTTAAAATATGAAAGAAACTA
TTTTCTTAATTATAAATTAGGTTTTTAGATTTTCATATTTGTGTTCATTT
TTTCCGCTGTTTCTAAACCTATCAAACGCTTCCATTCTCGGCCACTGAAA
CGGTTAAATTTAAATTCAATGTAAAATTAAAATTTAATATTTAAGTTGAA
ATAAAATAATAAAAGTAAATGCACACAGTTTATTCTCAATGTGATGTAGA
GGGAAAGATTTCTTATTGCAAGGGCCCCGAGAAGCTCCTGCTAGCTTCTA
GATATAAATGATATATGCCTGATTGTTTATATTTTGACTAAAATTCTGTC
TTTATTAATACAATAAATAAACAAATAACGCATGTTGCAAACCGATTCAT
GCGAATATAAAGTTGAGACAAGTTGAGAGATTCTATAATAATATTAAATT
GCATTTATATATGTTAATATTCAGAAAATTCGG
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protein sequence of SMED30008165-orf-1

>SMED30008165-orf-1 ID=SMED30008165-orf-1|Name=SMED30008165-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=528bp
MSEIFLYNINNWSGDEVESWIRGISPCLSEYLPFDKPSCDGRWLTNLSLS
DLKSVGFQKIGHAIILLDSVRILIDELHQMNNETLQNVIYRVSCNATSLI
NYVDKYLRLNESLEHFLQNRLSPFYDNEDQTFNSKQLYPGQLDEIQSIKM
IIISSVLKLTNSILVSLSWLNKPNFISVSELVDMKLGLLDDLKRLNRYTQ
YIVSDKGDQKFADVKGISNMIRYRTQSFIDSCRDSLYLTPCIIDTVQIHK
TENIVFGINVKTIFGNLHIIESIDINSPAYSIGKLEEGDEILEINNQIII
GWCHQSVIEEIRSHPRKLSLRLRKKPMHVNESINSGGRRNRNMPQNAGNS
GQLRGGVLTRPSKRINQAGLLGSVSTPATPVLLSKNVHINAGNSELLKQA
NHDIVNEMLRKLTLEHHNLDINKNEELGSESEYSAADASPYVIRHKIKPV
KETKLQDYDNIGNPFHKPIADTFTVLSEEDDAKSDFGSGEIYPRRSLTNE
NDSMDELLGPKSEKRQTDETFTSAVSP*
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protein sequence of SMED30008165-orf-2

>SMED30008165-orf-2 ID=SMED30008165-orf-2|Name=SMED30008165-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=292bp
MAKKSSGSKETEFNRQFDSNVVGQGCDGFIYMKRLHHLRNSYVKTWCSFQ
NKILSVFENKNGKHFEDINIEICHVTPLIKSGNNSFYFEVRHEWSTYHFG
TKDAKEYNKWINTLQSESLKSKPESDILHRNALFKSYSREESISQFESTS
SVFISDSNLSKPLENGDIYDEVTSPGVGNFSRNSPKGSIHSDNVFDNEKR
GENDDGRNDKSKQNSESLVMDKFKFMADLERQIRASFVLYISIKCAWLFS
CEICYTKCLYVYVILVLFYSGPGTGRTINGQTPELRIALGN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000034epidermis
PLANA:0000101muscle cell
PLANA:0000140anterior region of the whole animal
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR036034PDZ_sf
IPR041489PDZ_6
IPR001849PH_domain
IPR011993PH-like_dom_sf
IPR001478PDZ
IPR013761SAM/pointed_sf
IPR001660SAM
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0016301kinase activity
Vocabulary: biological process
TermDefinition
GO:0016310phosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001478PDZ domainSMARTSM00228pdz_newcoord: 254..326
e-value: 2.7E-10
score: 50.2
IPR001478PDZ domainPROSITEPS50106PDZcoord: 245..326
score: 14.114
IPR013761Sterile alpha motif/pointed domain superfamilyGENE3DG3DSA:1.10.150.50coord: 2..88
e-value: 7.4E-11
score: 44.0
IPR013761Sterile alpha motif/pointed domain superfamilySUPERFAMILYSSF47769SAM/Pointed domaincoord: 8..78
IPR036034PDZ superfamilyGENE3DG3DSA:2.30.42.10coord: 239..335
e-value: 5.0E-13
score: 50.9
IPR036034PDZ superfamilySUPERFAMILYSSF50156PDZ domain-likecoord: 221..325
IPR041489PDZ domain 6PFAMPF17820PDZ_6coord: 270..323
e-value: 1.3E-8
score: 34.6
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 480..527
NoneNo IPR availablePANTHERPTHR12844:SF42CONNECTOR ENHANCER OF KSR PROTEIN CNKcoord: 7..331
NoneNo IPR availablePANTHERPTHR12844CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAScoord: 7..331
NoneNo IPR availableCDDcd00992PDZ_signalingcoord: 245..323
e-value: 3.73145E-13
score: 62.9694
IPR001660Sterile alpha motif domainPROSITEPS50105SAM_DOMAINcoord: 12..76
score: 12.943