Selenoprotein M
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30008140 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Selenoprotein M vs. Ensembl Human
Match: SELENOM (selenoprotein M [Source:HGNC Symbol;Acc:HGNC:30397]) HSP 1 Score: 76.6406 bits (187), Expect = 2.274e-16 Identity = 37/96 (38.54%), Postives = 56/96 (58.33%), Query Frame = 2 Query: 209 IFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGP 496 + +A V +CGG +LN L EVK+F+ D+P +HN+ PGADP L LL + + L +MTREE L+ GF+ K+ + +VP ++ P Sbjct: 37 LTRARVETCGGUQLNRLKEVKAFVTQDIPFYHNLVMKHLPGADPELVLLGRRYEELERIPLSEMTREEINALVQELGFYRKAAPDAQVPPEYVWAP 132
BLAST of Selenoprotein M vs. Ensembl Human
Match: SELENOM (selenoprotein M [Source:HGNC Symbol;Acc:HGNC:30397]) HSP 1 Score: 76.6406 bits (187), Expect = 2.274e-16 Identity = 37/96 (38.54%), Postives = 56/96 (58.33%), Query Frame = 2 Query: 209 IFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGP 496 + +A V +CGG +LN L EVK+F+ D+P +HN+ PGADP L LL + + L +MTREE L+ GF+ K+ + +VP ++ P Sbjct: 37 LTRARVETCGGUQLNRLKEVKAFVTQDIPFYHNLVMKHLPGADPELVLLGRRYEELERIPLSEMTREEINALVQELGFYRKAAPDAQVPPEYVWAP 132
BLAST of Selenoprotein M vs. Ensembl Human
Match: SELENOM (selenoprotein M [Source:HGNC Symbol;Acc:HGNC:30397]) HSP 1 Score: 73.9442 bits (180), Expect = 2.236e-15 Identity = 37/96 (38.54%), Postives = 56/96 (58.33%), Query Frame = 2 Query: 209 IFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGP 496 + +A V +CGG +LN L EVK+F+ D+P +HN+ PGADP L LL + + L +MTREE L+ GF+ K+ + +VP ++ P Sbjct: 37 LTRARVETCGG-QLNRLKEVKAFVTQDIPFYHNLVMKHLPGADPELVLLGRRYEELERIPLSEMTREEINALVQELGFYRKAAPDAQVPPEYVWAP 131
BLAST of Selenoprotein M vs. Ensembl Zebrafish
Match: selenom (selenoprotein M [Source:NCBI gene;Acc:352913]) HSP 1 Score: 85.5001 bits (210), Expect = 1.017e-19 Identity = 43/99 (43.43%), Postives = 59/99 (59.60%), Query Frame = 2 Query: 209 IFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGPYGD 505 + +A V +CGG +LN + EVK+F+ D+PL+HN+ PGADP L LLN + + L +MTR E LL GF+ K ED+VP +FR P D Sbjct: 27 LARARVETCGGUQLNRMREVKAFVTQDIPLYHNLVMKHIPGADPELVLLNHYYEELDRIPLSEMTRAEINKLLAELGFYKKDHPEDQVPEEFRFSPAKD 125
BLAST of Selenoprotein M vs. Ensembl Mouse
Match: Selenom (selenoprotein M [Source:MGI Symbol;Acc:MGI:2149786]) HSP 1 Score: 77.411 bits (189), Expect = 7.359e-17 Identity = 38/98 (38.78%), Postives = 58/98 (59.18%), Query Frame = 2 Query: 203 KKIFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGP 496 + + + V +CGG +LN L EVK+F+ D+ L+HN+ PGADP L LL+ N + + + L MTR+E L+ GF+ KS E +VP ++ P Sbjct: 35 RGLARGRVETCGGUQLNRLKEVKAFVTEDIQLYHNLVMKHLPGADPELVLLSRNYQELERIPLSQMTRDEINALVQELGFYRKSAPEAQVPPEYLWAP 132
BLAST of Selenoprotein M vs. UniProt/SwissProt
Match: sp|G4WAW9|SELM_ERISI (Selenoprotein M OS=Eriocheir sinensis OX=95602 GN=Selenom PE=2 SV=1) HSP 1 Score: 97.8265 bits (242), Expect = 9.979e-24 Identity = 45/100 (45.00%), Postives = 67/100 (67.00%), Query Frame = 2 Query: 200 DKKIFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGPY 499 DK + KA V SC G +LN P K FI+ D+PLFHN +F GA P L LLN ++ + +F+L ++REE L+I +GF+ KS K+++VP ++++GPY Sbjct: 24 DKGVAKARVESCSGUQLNRYPGAKQFIQEDLPLFHNTKFQHIGGAAPELLLLNKQDQELERFDLKKLSREEINELMIKKGFYKKSSKDEQVPEEYQEGPY 123
BLAST of Selenoprotein M vs. UniProt/SwissProt
Match: sp|Q802G7|SELM_DANRE (Selenoprotein M OS=Danio rerio OX=7955 GN=Selenom PE=2 SV=2) HSP 1 Score: 85.8853 bits (211), Expect = 5.896e-19 Identity = 43/99 (43.43%), Postives = 59/99 (59.60%), Query Frame = 2 Query: 209 IFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGPYGD 505 + +A V +CGG +LN + EVK+F+ D+PL+HN+ PGADP L LLN + + L +MTR E LL GF+ K ED+VP +FR P D Sbjct: 27 LARARVETCGGUQLNRMREVKAFVTQDIPLYHNLVMKHIPGADPELVLLNHYYEELDRIPLSEMTRAEINKLLAELGFYKKGHPEDQVPEEFRFSPAKD 125
BLAST of Selenoprotein M vs. UniProt/SwissProt
Match: sp|Q6GP98|SELM_XENLA (Selenoprotein M OS=Xenopus laevis OX=8355 GN=selenom PE=2 SV=2) HSP 1 Score: 82.4185 bits (202), Expect = 6.774e-18 Identity = 41/98 (41.84%), Postives = 58/98 (59.18%), Query Frame = 2 Query: 203 KKIFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGP 496 ++I + V SCGG +LN L EVK F+ D+PL+HN++ PGADP L L+ S + + L DM R+E LL GF+ KS + VP +F+ P Sbjct: 28 ERINRGKVESCGGUQLNRLKEVKGFVTEDLPLYHNLEMKHIPGADPELVLITSRYEELERIPLSDMKRDEINQLLKDLGFYRKSSPDAPVPAEFKMAP 125
BLAST of Selenoprotein M vs. UniProt/SwissProt
Match: sp|Q8VHC3|SELM_MOUSE (Selenoprotein M OS=Mus musculus OX=10090 GN=Selenom PE=1 SV=3) HSP 1 Score: 77.411 bits (189), Expect = 5.148e-16 Identity = 38/98 (38.78%), Postives = 58/98 (59.18%), Query Frame = 2 Query: 203 KKIFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGP 496 + + + V +CGG +LN L EVK+F+ D+ L+HN+ PGADP L LL+ N + + + L MTR+E L+ GF+ KS E +VP ++ P Sbjct: 35 RGLARGRVETCGGUQLNRLKEVKAFVTEDIQLYHNLVMKHLPGADPELVLLSRNYQELERIPLSQMTRDEINALVQELGFYRKSAPEAQVPPEYLWAP 132
BLAST of Selenoprotein M vs. UniProt/SwissProt
Match: sp|Q8WWX9|SELM_HUMAN (Selenoprotein M OS=Homo sapiens OX=9606 GN=SELENOM PE=1 SV=3) HSP 1 Score: 76.6406 bits (187), Expect = 1.092e-15 Identity = 37/96 (38.54%), Postives = 56/96 (58.33%), Query Frame = 2 Query: 209 IFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGP 496 + +A V +CGG +LN L EVK+F+ D+P +HN+ PGADP L LL + + L +MTREE L+ GF+ K+ + +VP ++ P Sbjct: 37 LTRARVETCGGUQLNRLKEVKAFVTQDIPFYHNLVMKHLPGADPELVLLGRRYEELERIPLSEMTREEINALVQELGFYRKAAPDAQVPPEYVWAP 132
BLAST of Selenoprotein M vs. TrEMBL
Match: A0A1S3H6N6 (selenoprotein M-like OS=Lingula unguis OX=7574 GN=LOC106152566 PE=4 SV=1) HSP 1 Score: 107.842 bits (268), Expect = 5.954e-25 Identity = 60/129 (46.51%), Postives = 76/129 (58.91%), Query Frame = 2 Query: 113 FLFVLVVCSVKAEDDDEDFDEYLPAIASDDKKIFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGPY 499 LF+LVV + DED + DK++ A V SC G RLN LPEVK FI D+PLFHNV+F + GA P L LLN V + +L REEC LLI GF+ KS K+++VP +F +GPY Sbjct: 7 LLFILVVAIFAETEKDEDVE---------DKEVASARVESCAGURLNRLPEVKKFIFEDIPLFHNVEFKKVGGAPPDLLLLNKAGEVVKRIDLSKYNREECNQLLIDLGFYKKSDKDEDVPEEFLEGPY 126
BLAST of Selenoprotein M vs. TrEMBL
Match: K9M8M2 (Selenoprotein M OS=Penaeus monodon OX=6687 PE=2 SV=1) HSP 1 Score: 100.523 bits (249), Expect = 3.926e-22 Identity = 48/97 (49.48%), Postives = 66/97 (68.04%), Query Frame = 2 Query: 209 IFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGPY 499 I KA V SCGG RLN LPEVK FI D+PLFHN +F + GA P L LLN ++ V + L ++REEC L++ +GF+ K+ ++EVP ++ +GPY Sbjct: 29 IAKARVESCGGURLNRLPEVKKFIHEDIPLFHNAKFKQIGGAPPELVLLNRFDQVVERLPLDKLSREECNKLMLKKGFYKKNSPDEEVPEEYLNGPY 125
BLAST of Selenoprotein M vs. TrEMBL
Match: T1G3I0 (Sep15_SelM domain-containing protein OS=Helobdella robusta OX=6412 GN=20215628 PE=4 SV=1) HSP 1 Score: 95.5153 bits (236), Expect = 8.005e-21 Identity = 46/90 (51.11%), Postives = 59/90 (65.56%), Query Frame = 2 Query: 245 RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGPYGDEVK 514 RLN PEVK FI D+PLFHNV+F PGA P LY LN+ + V +L + RE C LLI +GFF ++ D VP +F+DGPYG+ V+ Sbjct: 1 RLNRYPEVKRFIFDDIPLFHNVEFKSVPGASPNLYFLNAQDEKVETVDLTQLDREGCNQLLIRKGFFKRNNPGDGVPPQFKDGPYGEHVE 90
BLAST of Selenoprotein M vs. TrEMBL
Match: A5J2A1 (Selenoprotein M OS=Penaeus vannamei OX=6689 GN=SelM PE=2 SV=2) HSP 1 Score: 94.3597 bits (233), Expect = 7.867e-20 Identity = 51/102 (50.00%), Postives = 69/102 (67.65%), Query Frame = 2 Query: 200 DKKIFKASVVSCGG*RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGPYGD 505 + I KA V SCGG RLN LPEVK FI D+PLFHN +F + GA P L LLN ++ V + L ++REEC L++ +GF+ KS E+EVP ++R+GPY + Sbjct: 26 ETAIAKARVESCGGURLNRLPEVKKFIHEDIPLFHNAKFKQIGGAPPELVLLNRFDQVVERLPLDKLSREECNKLMLKKGFYKKSSPEEEVPEEYRNGPYTE 127
BLAST of Selenoprotein M vs. TrEMBL
Match: R7UQI1 (Sep15_SelM domain-containing protein (Fragment) OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_146389 PE=4 SV=1) HSP 1 Score: 91.2781 bits (225), Expect = 2.803e-19 Identity = 44/86 (51.16%), Postives = 58/86 (67.44%), Query Frame = 2 Query: 245 RLNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGPYG 502 RLN LPEVK+FIR DV FHNV++ PGA+P L+LLN+ V KF+L + R+EC+ LL GF+ K +EVP +F+ GPY Sbjct: 1 RLNRLPEVKAFIREDVKFFHNVEYKAIPGANPDLFLLNAAGEKVQKFDLSKLNRKECEALLTDLGFYKKISSNEEVPEEFQKGPYA 86
BLAST of Selenoprotein M vs. Ensembl Cavefish
Match: selenom (selenoprotein M [Source:NCBI gene;Acc:352913]) HSP 1 Score: 76.2554 bits (186), Expect = 1.724e-16 Identity = 38/81 (46.91%), Postives = 49/81 (60.49%), Query Frame = 2 Query: 263 EVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFRDGPYGD 505 EVK+F+ D+PL+HN+ PGADP L LLN + + L DMTR E LL GF+ K++ EDEVP +FR P D Sbjct: 33 EVKAFVTQDIPLYHNLVMKHIPGADPELVLLNHYYEELDRIPLSDMTRTEINKLLAELGFYKKAQPEDEVPEEFRFSPAKD 113
BLAST of Selenoprotein M vs. Ensembl Medaka
Match: selenom (selenoprotein M-like [Source:NCBI gene;Acc:101173635]) HSP 1 Score: 73.9442 bits (180), Expect = 1.022e-15 Identity = 40/92 (43.48%), Postives = 54/92 (58.70%), Query Frame = 2 Query: 248 LNALPEVKSFIRFDVPLFHNVQFNESPGADPVLYLLNSNNRFVTKFNLIDMTREECKNLLIHRGFFMKSKKEDEVPVKFR-----DGPYGDE 508 L+ L VK+F+ D+PL+HN+ PGADP L LL+ + + L MTR E LL+ GF+ K K+EDEVP +FR D P+ DE Sbjct: 37 LHPLIMVKAFVTQDIPLYHNLVMKHIPGADPELVLLSHYYDELDRIALSHMTRTEINELLVKLGFYKKEKQEDEVPEEFRFSPAKDSPFKDE 128 The following BLAST results are available for this feature:
BLAST of Selenoprotein M vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 3
BLAST of Selenoprotein M vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Selenoprotein M vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Selenoprotein M vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of Selenoprotein M vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Selenoprotein M vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 1
BLAST of Selenoprotein M vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Selenoprotein M vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Selenoprotein M vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of Selenoprotein M vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Selenoprotein M vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Selenoprotein M vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Selenoprotein M vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of Selenoprotein M vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 0
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30008140 ID=SMED30008140|Name=Selenoprotein M|organism=Schmidtea mediterranea sexual|type=transcript|length=1043bpback to top Annotated Terms
The following terms have been associated with this transcript:
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