FHA domain-containing protein

Overview
NameFHA domain-containing protein
Smed IDSMED30008121
Length (bp)1166
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of FHA domain-containing protein (SMED30008121) t-SNE clustered cells

Violin plots show distribution of expression levels for FHA domain-containing protein (SMED30008121) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of FHA domain-containing protein (SMED30008121) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for FHA domain-containing protein (SMED30008121) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30008121

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30008121SMESG000055731.1 SmedASXL_010266SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30008121SMESG000055731.1 SmedASXL_010266SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Human
Match: PPP1R8 (protein phosphatase 1 regulatory subunit 8 [Source:HGNC Symbol;Acc:HGNC:9296])

HSP 1 Score: 288.886 bits (738), Expect = 7.549e-95
Identity = 167/360 (46.39%), Postives = 214/360 (59.44%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGL-------GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASR------------SDLPPSRDD----PHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F  P WAGKPPPGLHLDV+K  KLI+KL+IDEK+ Y FGRN  LCDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQIPIDS + FGASTR Y +RE+P ++ + +       G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +EIINPED+DPS+GRFRN+VQ   +P K+++V     LG      + SR              LPP+  +    PH                       +    L +P PNLAP+VD +    +PS   ++ +     +    N    +EP+KKKYAKEAWPGKKP 
Sbjct:   14 FDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEGPGSLGLEE---SGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIH------------------GTALIGGLPMPYPNLAPDVDLTP--VVPSAVNMNPAP----NPAVYNPEAVNEPKKKKYAKEAWPGKKPT 346
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Human
Match: PPP1R8 (protein phosphatase 1 regulatory subunit 8 [Source:HGNC Symbol;Acc:HGNC:9296])

HSP 1 Score: 118.242 bits (295), Expect = 6.944e-31
Identity = 83/229 (36.24%), Postives = 117/229 (51.09%), Query Frame = 3 
Query:  444 GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASR------------SDLPPSRDD----PHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +EIINPED+DPS+GRFRN+VQ   +P K+++V     LG      + SR              LPP+  +    PH                       +    L +P PNLAP+VD +    +PS   ++ + +  +     N    +EP+KKKYAKEAWPGKKP 
Sbjct:    3 GEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEGPGSLGLEE---SGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIH------------------GTALIGGLPMPYPNLAPDVDLTPV--VPSAVNMNPAPNPAV----YNPEAVNEPKKKKYAKEAWPGKKPT 204
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Human
Match: PPP1R8 (protein phosphatase 1 regulatory subunit 8 [Source:HGNC Symbol;Acc:HGNC:9296])

HSP 1 Score: 118.627 bits (296), Expect = 7.168e-31
Identity = 83/229 (36.24%), Postives = 116/229 (50.66%), Query Frame = 3 
Query:  444 GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASR------------SDLPPSRDD----PHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +EIINPED+DPS+GRFRN+VQ   +P K+++V     LG      + SR              LPP+  +    PH                       +    L +P PNLAP+VD +    +PS   ++ +     +    N    +EP+KKKYAKEAWPGKKP 
Sbjct:    3 GEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEGPGSLGLEE---SGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIH------------------GTALIGGLPMPYPNLAPDVDLTPV--VPSAVNMNPAP----NPAVYNPEAVNEPKKKKYAKEAWPGKKPT 204
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Human
Match: SNIP1 (Smad nuclear interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:30587])

HSP 1 Score: 56.6102 bits (135), Expect = 2.934e-8
Identity = 34/124 (27.42%), Postives = 60/124 (48.39%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLH-----------RPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            +  P  A  P     L   K+ +++  + I  +  Y  GR+R++ D PIDH S S+ H    +    +           +P++IDL S +GTF+ + R+E  +  ++     + FG S+R YV+
Sbjct:  246 YSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVL 369
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Human
Match: SLC4A1AP (solute carrier family 4 member 1 adaptor protein [Source:HGNC Symbol;Acc:HGNC:13813])

HSP 1 Score: 54.299 bits (129), Expect = 2.880e-7
Identity = 34/124 (27.42%), Postives = 59/124 (47.58%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHK--------DLHRP--FLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIR 413
            ++ P W G       L+ +K G ++    +       FGR    CD  ++H S SR H A++ H+        D + P  +L DL S HGTF+   R+      ++ +   + FG STR+++++
Sbjct:  100 YQEPPWGGPATAPYSLETLKGGTILGTRSLKGTSYCLFGR-LSGCDVCLEHPSVSRYH-AVLQHRASGPDGECDSNGPGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVVRFGGSTRLFILQ 221
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Celegans
Match: B0511.7 (pep chromosome:WBcel235:I:10631665:10633150:-1 gene:WBGene00015233.1 transcript:B0511.7.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:B0511.7)

HSP 1 Score: 187.963 bits (476), Expect = 1.317e-56
Identity = 127/341 (37.24%), Postives = 174/341 (51.03%), Query Frame = 3 
Query:   66 NNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTGNLPDDEEELDNLTEFNTAQNRRNTSI-INMKDSKVKRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFI---PNKRQKVSTVAPLGTSSYLMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINP-AFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKP 1073
            + FK+P WA KPP G HLDV K   LIQKL+ID+K+ Y+FGRN +  DF ++H S SRVH  L++H  L R  LID+ S HGTF+G++RL   +   +   ++ H GASTR Y +R         L     +     +   +E+LD+ T +NTAQNRR   + I++++++ K+   +    V F ++EE+INPED+DPS+GRFRNLV    I   PNKR                        P R +P    +       SA   +   P A +AA  L L    L PE                   H  +  TA     DD   KK+YAKEAWPG+KP
Sbjct:    8 SKFKVPSWAAKPPNGAHLDVQKGDALIQKLLIDDKKAYYFGRNNKQVDFAVEHASCSRVHALLLYHGLLQRFALIDMDSSHGTFLGNVRLRPLEVVFMDPGTQFHLGASTRKYSVR---------LKTEHHVEDDPTVAASDEQLDHQTSYNTAQNRRIPQLPISVEEARRKK---RPRGNVAFLEEEEVINPEDVDPSVGRFRNLVTTAIISTNPNKRPG---------------------DPKRSEPPRKIVRPGRELMSAPLSSTFGPMALNAAPDLEL-YGKLLPE----------------PGHHQYVTSTATEDEADDH-HKKRYAKEAWPGRKP 297
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Celegans
Match: C32E8.5 (pep chromosome:WBcel235:I:3782118:3783232:1 gene:WBGene00016323.1 transcript:C32E8.5.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C32E8.5)

HSP 1 Score: 60.4622 bits (145), Expect = 4.850e-10
Identity = 40/142 (28.17%), Postives = 64/142 (45.07%), Query Frame = 3 
Query:   69 NFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHK---------DLHR--PFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDL 461
             +  P  A KP     L   K  + +Q L I  +  Y  GR+ ++ D P+DH S S+ H  L +              R  P++IDL S +GTF+   ++E  +  ++     + FG STR YV+ +     +  L   ED+
Sbjct:  152 KYNEPPEAKKPNARWRLYPFKGEESLQVLYIHRQSAYLIGRDHKIADIPVDHPSCSKQHAVLQFRSMPFTRDDGTKARRIMPYIIDLGSGNGTFLNEKKIEPQRYIELQEKDMLKFGFSTREYVVMKEREITEEELAEGEDV 293
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Celegans
Match: C32E8.5 (pep chromosome:WBcel235:I:3782118:3783294:1 gene:WBGene00016323.1 transcript:C32E8.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C32E8.5)

HSP 1 Score: 60.4622 bits (145), Expect = 4.850e-10
Identity = 40/142 (28.17%), Postives = 64/142 (45.07%), Query Frame = 3 
Query:   69 NFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHK---------DLHR--PFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDL 461
             +  P  A KP     L   K  + +Q L I  +  Y  GR+ ++ D P+DH S S+ H  L +              R  P++IDL S +GTF+   ++E  +  ++     + FG STR YV+ +     +  L   ED+
Sbjct:  152 KYNEPPEAKKPNARWRLYPFKGEESLQVLYIHRQSAYLIGRDHKIADIPVDHPSCSKQHAVLQFRSMPFTRDDGTKARRIMPYIIDLGSGNGTFLNEKKIEPQRYIELQEKDMLKFGFSTREYVVMKEREITEEELAEGEDV 293
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Celegans
Match: ZK632.2 (pep chromosome:WBcel235:III:9799107:9802333:1 gene:WBGene00014011.1 transcript:ZK632.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK632.2)

HSP 1 Score: 48.521 bits (114), Expect = 7.197e-6
Identity = 33/121 (27.27%), Postives = 57/121 (47.11%), Query Frame = 3 
Query:   69 NFKIPDWAGKPPPG--LHLDVMKDGKLIQKLMIDEKRCYFF---GRNRQLCDFPIDHQSGSRVHGALVWHKDLHRP-----FLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRM 401
            ++++P WA +P P      +++K+GKLI    +  ++   F   GR +  CD  ++H S SR H  L +  D          + +L S HG+ +   RL   +  +  +     FG STR+
Sbjct:   67 HYEVPPWACEPDPAHKFQFEILKEGKLIASYDLSNRKNSTFVVIGRIKPGCDLLMEHPSISRYHCILQYGNDKMSKTGKGWHIFELGSTHGSRMNKKRLPPKQYIRTRVGFIFQFGESTRI 187
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Fly
Match: NiPp1 (gene:FBgn0026402 transcript:FBtr0087058)

HSP 1 Score: 275.404 bits (703), Expect = 1.855e-89
Identity = 164/384 (42.71%), Postives = 224/384 (58.33%), Query Frame = 3 
Query:   60 LTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTGN-----LPDDEEELDNLTEFNTAQNRRNTSIINMKDSKVKRPSH-----KANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQK--VSTVAPLGTSSYLMTASRS------------------DLPPSRDDPHYXXXXXXXXXXXXXXXXA----INPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDE-----------PRKKKYAKEAWPGKKPV 1076
            + N++ IP WAGKPP GLHLDV+KD KL+QKLM+DEKRCY FGRN Q+ DF IDH S SRVH A V+HK L+  +L+DL S HGTFIG++RLE  KP Q+ I+S  HFGASTR Y++RERP    + +     LS T +     LP+ + ELDNLTE+NTA NRR  S++ + D    R  +     +    V F D+E +INPED+DP++GRFRNLVQ T +P KR +  V+ +     +S L +A+ +                  ++PP     H  +  +     +  H       I+P  S  +KLGL +PN APEV     EA+ + TL   +Q + +    + +  +D            P+KKKYAKEAWPG+KP+
Sbjct:    1 MANSYDIPSWAGKPPTGLHLDVLKDDKLVQKLMVDEKRCYLFGRNSQMNDFCIDHASCSRVHSAFVYHKHLNIAYLVDLGSTHGTFIGTLRLEAHKPTQLQINSTFHFGASTRNYILRERPSGHHSNIMEDLPLSETSDGALLGLPESQTELDNLTEYNTAHNRR-ISMLGIDDDTNMRKQNALKQGRRTRNVTFNDEEIVINPEDVDPNVGRFRNLVQTTVVPAKRARCDVNHMGIHSGNSSLSSANAAHVHQMFQQSLVDMKQQHREMPPPNAVLHSPTNSLYQGLPAEMHGKGDLEPISP-LSIGSKLGLLLPNPAPEVLPVYDEAVETSTL---AQKLAVANANVRRFGEDPHDSSGEGDSLCPQKKKYAKEAWPGRKPM 379
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Fly
Match: CG17168 (gene:FBgn0039943 transcript:FBtr0113730)

HSP 1 Score: 61.6178 bits (148), Expect = 4.640e-10
Identity = 38/124 (30.65%), Postives = 59/124 (47.58%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVW-----------HKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            +  P  A KP     L   K    +  L I  + C+  GR+R++ D  +DH S S+ H AL +           H    R +LIDL S +GTF+ + +++  K  ++     I FG S+R YV+
Sbjct:  268 YSEPPEARKPKRRWRLYPFKGETALPTLHIHRQSCFLVGRDRKVVDLAVDHPSCSKQHAALQYRLVPFEREDGSHGKRVRLYLIDLDSANGTFLNNKKIDARKYYELIEKDVIKFGFSSREYVL 391
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Match: ppp1r8a (protein phosphatase 1, regulatory subunit 8a [Source:ZFIN;Acc:ZDB-GENE-060503-681])

HSP 1 Score: 268.47 bits (685), Expect = 5.570e-87
Identity = 170/361 (47.09%), Postives = 211/361 (58.45%), Query Frame = 3 
Query:   45 AIAQNLTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERP---GSMQNGLGRA---EDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSY---------LMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            AIA   T  F  P WAGKPPPGLHLDV+K  KLI+KL+IDEK+ Y FGRN   CDF IDHQS SRVH ALV+H+ L R FLIDL+S HGTF+G IRLE  KPQQ+PIDS + FGASTR+Y +RE+P    S   G  +    E+L     LP++E EL+NLTEFNTA N+R +T  I   + +++RP  K  +  V F++ EEIINPED+DPS+GRFRN+VQ   +P K++K+   + LG             L      DLPP+  +            +            +    + LP PN APEVD S     P   L  +          LN     EPRKKKYAKEAWPGKKP 
Sbjct:    3 AIASTNTTGFDCPSWAGKPPPGLHLDVVKGDKLIEKLIIDEKKFYLFGRNPDHCDFTIDHQSCSRVHAALVYHRHLKRVFLIDLNSTHGTFLGRIRLEPHKPQQVPIDSTMSFGASTRVYTLREKPQTQSSSTTGDSKGVEDEELKGLLGLPEEETELENLTEFNTAHNKRISTLTIEEGNLEIQRPKRKRKSSRVSFSEDEEIINPEDVDPSVGRFRNMVQTAVVPIKKKKLEGHSTLGLDENVARRLQNFPLSGGLYGDLPPTSHE------------AGGQGGGGQGGGSAITGGMPLPFPNPAPEVDVSPTTVQPPAMLNPTPAPGPYSAEPLN-----EPRKKKYAKEAWPGKKPT 346
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Match: ppp1r8b (protein phosphatase 1, regulatory subunit 8b [Source:ZFIN;Acc:ZDB-GENE-040426-1271])

HSP 1 Score: 248.054 bits (632), Expect = 3.687e-79
Identity = 164/354 (46.33%), Postives = 208/354 (58.76%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRA-------EDLSFTGNLPDDEEELDNLTEFNTAQNRRNTSIINMKDSKV---KRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSY---------LMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F  P WAGKPP GLHLDV+K  KL++KL+IDEK+ Y FGRN  +CDF IDHQS SRVH ALV+H+ L R FLIDL+S HGTF+G IRLE  KPQQ+PIDS + FGASTR+Y IRE+P   Q G G         E+L     LP++E EL+NLTEFNTA N+R  S + +++  +   +    + +  V F + +EIINPED+DPS+GRFRN+V    +P K++K      LG             L      DLPP+  +                   A     +    + LPMPN AP+VD  T EALP   L+ +   +T    +   N   EPRKKKYAKEAWPGKKP 
Sbjct:   12 FDCPSWAGKPPAGLHLDVVKGDKLVEKLIIDEKKFYLFGRNPDICDFTIDHQSCSRVHAALVYHRHLKRLFLIDLNSTHGTFLGHIRLEPHKPQQVPIDSTMSFGASTRVYTIREKP-QAQPGAGVGDIKTGDDEELKGLLGLPEEETELENLTEFNTAHNKR-ISTLTIEEGNLDIQRPKRKRRSSRVSFNEDDEIINPEDVDPSVGRFRNMVSTAVVPIKKKKAGGSNALGIEETVARHMHTFPLQGGLYRDLPPAGHE---------------AQSTAGPGGATILGGMMLPMPNPAPDVD-PTHEALPPPPLMLNPTPMTGPYVSDVLN---EPRKKKYAKEAWPGKKPT 344
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Match: ppp1r8b (protein phosphatase 1, regulatory subunit 8b [Source:ZFIN;Acc:ZDB-GENE-040426-1271])

HSP 1 Score: 248.054 bits (632), Expect = 4.107e-79
Identity = 164/354 (46.33%), Postives = 208/354 (58.76%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRA-------EDLSFTGNLPDDEEELDNLTEFNTAQNRRNTSIINMKDSKV---KRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSY---------LMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F  P WAGKPP GLHLDV+K  KL++KL+IDEK+ Y FGRN  +CDF IDHQS SRVH ALV+H+ L R FLIDL+S HGTF+G IRLE  KPQQ+PIDS + FGASTR+Y IRE+P   Q G G         E+L     LP++E EL+NLTEFNTA N+R  S + +++  +   +    + +  V F + +EIINPED+DPS+GRFRN+V    +P K++K      LG             L      DLPP+  +                   A     +    + LPMPN AP+VD  T EALP   L+ +   +T    +   N   EPRKKKYAKEAWPGKKP 
Sbjct:   12 FDCPSWAGKPPAGLHLDVVKGDKLVEKLIIDEKKFYLFGRNPDICDFTIDHQSCSRVHAALVYHRHLKRLFLIDLNSTHGTFLGHIRLEPHKPQQVPIDSTMSFGASTRVYTIREKP-QAQPGAGVGDIKTGDDEELKGLLGLPEEETELENLTEFNTAHNKR-ISTLTIEEGNLDIQRPKRKRRSSRVSFNEDDEIINPEDVDPSVGRFRNMVSTAVVPIKKKKAGGSNALGIEETVTRHMHTFPLQGGLYRDLPPAGHE---------------AQSTAGPGGATILGGMMLPMPNPAPDVD-PTHEALPPPPLMLNPTPMTGPYVSDVLN---EPRKKKYAKEAWPGKKPT 344
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Match: snip1 (Smad nuclear interacting protein [Source:ZFIN;Acc:ZDB-GENE-041026-3])

HSP 1 Score: 53.1434 bits (126), Expect = 1.611e-7
Identity = 28/97 (28.87%), Postives = 48/97 (49.48%), Query Frame = 3 
Query:  153 LMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWH-----------KDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            + I  +  Y  GR R++ D PIDH S S+ H    +                +P++IDL S +GT++ + R+E  +  ++     + FG S+R YV+
Sbjct:  138 MYIHRQSAYLLGRLRKIADIPIDHPSCSKQHAVFQYRLVEFTRVDGTAGRRVKPYIIDLGSGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVL 234
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Match: snip1 (Smad nuclear interacting protein [Source:ZFIN;Acc:ZDB-GENE-041026-3])

HSP 1 Score: 52.7582 bits (125), Expect = 3.684e-7
Identity = 28/97 (28.87%), Postives = 48/97 (49.48%), Query Frame = 3 
Query:  153 LMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWH-----------KDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            + I  +  Y  GR R++ D PIDH S S+ H    +                +P++IDL S +GT++ + R+E  +  ++     + FG S+R YV+
Sbjct:  251 MYIHRQSAYLLGRLRKIADIPIDHPSCSKQHAVFQYRLVEFTRVDGTAGRRVKPYIIDLGSGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVL 347
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Match: ak6 (adenylate kinase 6 [Source:Xenbase;Acc:XB-GENE-972292])

HSP 1 Score: 292.352 bits (747), Expect = 2.543e-96
Identity = 166/353 (47.03%), Postives = 212/353 (60.06%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGL------GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLG--------TSSYLMTAS-RSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNS-TFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F+ P WAGKPP GLHLDV+K  KLI+KL+IDEK+ Y FGRN  +CDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQIPIDS I FGASTRMY +RE+P ++ + L      G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +E+INPED+DPS+GRFRN+VQ   +P K++K      L           ++  T      LPP+  +                  A        A   G+P PNLAPEVD + T   +  +T+  +    T +         +EP+KKKYAKEAWPGKKP 
Sbjct:   12 FECPSWAGKPPQGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDICDFTIDHQSCSRVHSALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTISFGASTRMYTLREKPQTLPSALKGDEKAGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNIDIQRPKRKRKNSRVTFSEDDEVINPEDVDPSVGRFRNMVQTAVVPVKKKKTEIPGSLSLEDSVGRRVQNFPFTGGLYGGLPPTHAE----------------GGAQTAGGHGTALMGGMPFPNLAPEVDLAPTTATVAPITVAPAPSSFTAEAV-------NEPKKKKYAKEAWPGKKPT 341
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Match: ak6 (adenylate kinase 6 [Source:Xenbase;Acc:XB-GENE-972292])

HSP 1 Score: 287.345 bits (734), Expect = 1.634e-94
Identity = 166/348 (47.70%), Postives = 211/348 (60.63%), Query Frame = 3 
Query:   87 WAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGL------GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLG--------TSSYLMTAS-RSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNS-TFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            WAGKPP GLHLDV+K  KLI+KL+IDEK+ Y FGRN  +CDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQIPIDS I FGASTRMY +RE+P ++ + L      G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +E+INPED+DPS+GRFRN+VQ   +P K++K      L           ++  T      LPP+  +                  A        A   G+P PNLAPEVD + T   +  +T+  +    T +  A+N     EP+KKKYAKEAWPGKKP 
Sbjct:    1 WAGKPPQGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDICDFTIDHQSCSRVHSALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTISFGASTRMYTLREKPQTLPSALKGDEKAGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNIDIQRPKRKRKNSRVTFSEDDEVINPEDVDPSVGRFRNMVQTAVVPVKKKKTEIPGSLSLEDSVGRRVQNFPFTGGLYGGLPPTHAE----------------GGAQTAGGHGTALMGGMPFPNLAPEVDLAPTTATVAPITVAPAPSSFTAE--AVN-----EPKKKKYAKEAWPGKKPT 325
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Match: ak6 (adenylate kinase 6 [Source:Xenbase;Acc:XB-GENE-972292])

HSP 1 Score: 283.108 bits (723), Expect = 8.462e-93
Identity = 165/348 (47.41%), Postives = 210/348 (60.34%), Query Frame = 3 
Query:   87 WAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGL------GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLG--------TSSYLMTAS-RSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNS-TFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
             AGKPP GLHLDV+K  KLI+KL+IDEK+ Y FGRN  +CDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQIPIDS I FGASTRMY +RE+P ++ + L      G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +E+INPED+DPS+GRFRN+VQ   +P K++K      L           ++  T      LPP+  +                  A        A   G+P PNLAPEVD + T   +  +T+  +    T +  A+N     EP+KKKYAKEAWPGKKP 
Sbjct:    1 MAGKPPQGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDICDFTIDHQSCSRVHSALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTISFGASTRMYTLREKPQTLPSALKGDEKAGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNIDIQRPKRKRKNSRVTFSEDDEVINPEDVDPSVGRFRNMVQTAVVPVKKKKTEIPGSLSLEDSVGRRVQNFPFTGGLYGGLPPTHAE----------------GGAQTAGGHGTALMGGMPFPNLAPEVDLAPTTATVAPITVAPAPSSFTAE--AVN-----EPKKKKYAKEAWPGKKPT 325
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Match: snip1 (Smad nuclear interacting protein 1 [Source:NCBI gene;Acc:394485])

HSP 1 Score: 59.6918 bits (143), Expect = 2.792e-9
Identity = 35/124 (28.23%), Postives = 58/124 (46.77%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWH-----------KDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            +  P  A  P     L   K+ + +  + I  +  Y  GR R++ D PIDH S S+ H  L +                RP++IDL S +GT++ + R+E  +  ++     + FG S+R YV+
Sbjct:  218 YSEPPEARTPKKRWRLYPFKNDEALPVMYIHRQSAYLLGRQRRIADIPIDHPSCSKQHAVLQYRMVQFTRANGTSGRRVRPYIIDLGSGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVV 341
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Match: alkbh7 (alkB homolog 7 [Source:Xenbase;Acc:XB-GENE-958693])

HSP 1 Score: 56.6102 bits (135), Expect = 3.754e-8
Identity = 42/166 (25.30%), Postives = 72/166 (43.37%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVW-HKDLHRP------FLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTGNLPDDEEELD-NLTEFNTAQNRRNT 545
            ++ P W+G P     L+++K G ++    +       FGR    C   ++H S SR H  L + H     P      ++ DL S HGTF+   R++     +I +   + FG STR+++++                   G   D EEE D  +T+   A+ +R +
Sbjct:   45 YREPPWSGLPEALYCLEILKGGSIVSTKNLGNVSWTVFGRLPS-CHVSLEHPSVSRYHAVLQYRHVQGSGPDEEPGFYVYDLGSTHGTFLNKQRIQAKTYCRIRVGHVLKFGGSTRLFILQ-------------------GPEEDQEEESDLTVTQIKEARRQRES 190
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Mouse
Match: Ppp1r8 (protein phosphatase 1, regulatory subunit 8 [Source:MGI Symbol;Acc:MGI:2140494])

HSP 1 Score: 290.812 bits (743), Expect = 1.112e-95
Identity = 167/360 (46.39%), Postives = 214/360 (59.44%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGL-------GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASR------------SDLPPSRDD----PHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F  P WAGKPPPGLHLDV+K  KLI+KL+IDEK+ Y FGRN  LCDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQIPIDS + FGASTR Y +RE+P ++ + +       G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +EIINPED+DPS+GRFRN+VQ   +P K++++     LG      + SR              LPP+  +    PH                       +    L +P PNLAP+VD +    +PS   ++     T +    N    +EP+KKKYAKEAWPGKKP 
Sbjct:   14 FDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRMEGSGSLGLEE---SGSRRMQNFAFSGGLYGGLPPTHSETGSQPHGIH------------------GTALIGGLPMPYPNLAPDVDLTP--VVPSAVAINP----TPNPAVYNPEAVNEPKKKKYAKEAWPGKKPT 346
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Mouse
Match: Ppp1r8 (protein phosphatase 1, regulatory subunit 8 [Source:MGI Symbol;Acc:MGI:2140494])

HSP 1 Score: 286.189 bits (731), Expect = 6.139e-94
Identity = 166/360 (46.11%), Postives = 213/360 (59.17%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGL-------GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASR------------SDLPPSRDD----PHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F  P WAGKPPPGLHLDV+K  KLI+KL+IDEK+ Y FGRN  LCDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQIPIDS + FGASTR Y +RE+P ++ + +       G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +EIINPED+DPS+GRFRN+VQ   +P K++   +    G+     + SR              LPP+  +    PH                       +    L +P PNLAP+VD +    +PS   ++     T +    N    +EP+KKKYAKEAWPGKKP 
Sbjct:   14 FDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKRMEGS----GSLGLEESGSRRMQNFAFSGGLYGGLPPTHSETGSQPHGIH------------------GTALIGGLPMPYPNLAPDVDLTP--VVPSAVAINP----TPNPAVYNPEAVNEPKKKKYAKEAWPGKKPT 345
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Mouse
Match: Slc4a1ap (solute carrier family 4 (anion exchanger), member 1, adaptor protein [Source:MGI Symbol;Acc:MGI:1196608])

HSP 1 Score: 58.5362 bits (140), Expect = 6.751e-9
Identity = 34/124 (27.42%), Postives = 60/124 (48.39%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHK--------DLHRP--FLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIR 413
            ++ P W         L+ +K G ++    + +  C FFGR    CD  ++H S SR H A++ H+        + H    +L DL S HGTF+   R+      ++ +   + FG STR+++++
Sbjct:  100 YREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRLAS-CDICLEHPSVSRYH-AVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFILQ 221
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Mouse
Match: Slc4a1ap (solute carrier family 4 (anion exchanger), member 1, adaptor protein [Source:MGI Symbol;Acc:MGI:1196608])

HSP 1 Score: 58.5362 bits (140), Expect = 7.669e-9
Identity = 34/124 (27.42%), Postives = 60/124 (48.39%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHK--------DLHRP--FLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIR 413
            ++ P W         L+ +K G ++    + +  C FFGR    CD  ++H S SR H A++ H+        + H    +L DL S HGTF+   R+      ++ +   + FG STR+++++
Sbjct:  100 YREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRLAS-CDICLEHPSVSRYH-AVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFILQ 221
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Mouse
Match: Slc4a1ap (solute carrier family 4 (anion exchanger), member 1, adaptor protein [Source:MGI Symbol;Acc:MGI:1196608])

HSP 1 Score: 58.5362 bits (140), Expect = 8.101e-9
Identity = 34/124 (27.42%), Postives = 60/124 (48.39%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHK--------DLHRP--FLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIR 413
            ++ P W         L+ +K G ++    + +  C FFGR    CD  ++H S SR H A++ H+        + H    +L DL S HGTF+   R+      ++ +   + FG STR+++++
Sbjct:  100 YREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRLAS-CDICLEHPSVSRYH-AVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFILQ 221
[Close]
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8R3G1|PP1R8_MOUSE (Nuclear inhibitor of protein phosphatase 1 OS=Mus musculus OX=10090 GN=Ppp1r8 PE=1 SV=1)

HSP 1 Score: 290.812 bits (743), Expect = 7.777e-95
Identity = 167/360 (46.39%), Postives = 214/360 (59.44%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGL-------GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASR------------SDLPPSRDD----PHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F  P WAGKPPPGLHLDV+K  KLI+KL+IDEK+ Y FGRN  LCDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQIPIDS + FGASTR Y +RE+P ++ + +       G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +EIINPED+DPS+GRFRN+VQ   +P K++++     LG      + SR              LPP+  +    PH                       +    L +P PNLAP+VD +    +PS   ++     T +    N    +EP+KKKYAKEAWPGKKP 
Sbjct:   14 FDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRMEGSGSLGLEE---SGSRRMQNFAFSGGLYGGLPPTHSETGSQPHGIH------------------GTALIGGLPMPYPNLAPDVDLTP--VVPSAVAINP----TPNPAVYNPEAVNEPKKKKYAKEAWPGKKPT 346
[Close]
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q12972|PP1R8_HUMAN (Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2)

HSP 1 Score: 288.886 bits (738), Expect = 3.625e-94
Identity = 167/360 (46.39%), Postives = 214/360 (59.44%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGL-------GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASR------------SDLPPSRDD----PHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F  P WAGKPPPGLHLDV+K  KLI+KL+IDEK+ Y FGRN  LCDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQIPIDS + FGASTR Y +RE+P ++ + +       G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +EIINPED+DPS+GRFRN+VQ   +P K+++V     LG      + SR              LPP+  +    PH                       +    L +P PNLAP+VD +    +PS   ++ +     +    N    +EP+KKKYAKEAWPGKKP 
Sbjct:   14 FDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEGPGSLGLEE---SGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIH------------------GTALIGGLPMPYPNLAPDVDLTP--VVPSAVNMNPAP----NPAVYNPEAVNEPKKKKYAKEAWPGKKPT 346
[Close]
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q28147|PP1R8_BOVIN (Nuclear inhibitor of protein phosphatase 1 OS=Bos taurus OX=9913 GN=PPP1R8 PE=1 SV=1)

HSP 1 Score: 288.115 bits (736), Expect = 8.173e-94
Identity = 167/362 (46.13%), Postives = 215/362 (59.39%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGL-------GRAEDLSFTGNLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRS--------------DLPPSRDD----PHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F  P WAGKPPPGLHLDV+K  KLI+KL+IDEK+ Y FGRN  LCDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQIPIDS + FGASTR Y +RE+P ++ + +       G  ++L     LP++E ELDNLTEFNTA N+R +T  I   +  ++RP  K  N  V F++ +EIINPED+DPS+GRFRN+VQ   +P K+++V      G  S ++  S S               LPP+  +    PH                       +    L +P PNLAP+VD +    +PS   ++ +     +    N    +EP+KKKYAKEAWPGKKP 
Sbjct:   14 FDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVE-----GPGSLVLEESGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIH------------------GTALIGGLPMPYPNLAPDVDLTP--VVPSAVNMNPAP----NPAVYNPEAVNEPKKKKYAKEAWPGKKPT 346
[Close]
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9FIK2|PP1R8_ARATH (Protein phosphatase 1 regulatory inhibitor subunit PPP1R8 homolog OS=Arabidopsis thaliana OX=3702 GN=At5g47790 PE=1 SV=1)

HSP 1 Score: 105.916 bits (263), Expect = 3.755e-24
Identity = 77/256 (30.08%), Postives = 128/256 (50.00%), Query Frame = 3 
Query:   66 NNFKIPDWAGKPPPGLH-LDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTGNLPDDEEELDNLTEFNTAQNRRNTS------IINMKDSKVKRPSHKA----NLYVHFTDQ-----EEIINPED-----IDPS---------IGRFRNLVQETFIPNKRQKVSTVAPLGT 743
            +N+  PDWA +P  G++ L+V+KDG+++ ++ +D +R + FGR  Q CDF +DHQS SR H A+V HK+    F+IDL S HGTF+ + RL    P ++ +   + F ASTR+Y++R+   ++ +      ++      P D  + + +  +NT  NR   S      ++  +  K    +  A     + V F DQ      EI+   D      +P          +G++ +LV+ T IP  + K       GT
Sbjct:   50 SNWHPPDWAIEPRAGVYSLEVVKDGQILDRIHLDRRR-HIFGRQHQTCDFVLDHQSVSRQHAAVVPHKN-GSIFVIDLGSAHGTFVANERLTKDTPVELEVGQSLRFAASTRIYLLRKNSEALFSRPPPPAEIKLP--PPPDASDEEAVVAYNTLLNRYGLSNGESGGMLGKRKEKTGSEAGVAKRMKKVRVSFRDQLGGELAEIVGMSDGADVETEPGPINVKEGSLVGKYESLVRVTLIPKGKVKEEKAFTGGT 301
[Close]
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8W4D8|DDL_ARATH (FHA domain-containing protein DDL OS=Arabidopsis thaliana OX=3702 GN=DDL PE=1 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 2.701e-11
Identity = 40/126 (31.75%), Postives = 65/126 (51.59%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGK-LIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLH------------RPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            F  P  A KP     L V KDG+ L + L +  + CY FGR R++ D P DH S S+ H A++ ++++             +P+++DL S + T+I    +E  +  ++     I FG S+R YV+
Sbjct:  183 FNEPPEARKPSERWRLYVFKDGEPLNEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQH-AVIQYREMEKEKPDGMMGKQVKPYIMDLGSTNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVL 307
[Close]
BLAST of FHA domain-containing protein vs. TrEMBL
Match: A0A0R3UPT3 (FHA domain-containing protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS9867 PE=4 SV=1)

HSP 1 Score: 361.688 bits (927), Expect = 1.020e-119
Identity = 203/381 (53.28%), Postives = 252/381 (66.14%), Query Frame = 3 
Query:   60 LTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNG--------LGRAEDLSFTGN-LPDDEEELDNLTEFNTAQNRRNTSIINMKDS-------KVKRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDN------STFEALPSVTLVHSSQHITLDQTALNKNQ----------DD----EPRKKKYAKEAWPGKKPVGFAVGP 1094
            L NNFKIP WA KPPPG+HLDVMKDGKLIQKLM+DEK CYFFGRNRQLCDF IDHQS SR+H ALVWHK+L+R FLIDL SVHGTFIG I+LE  +PQQ+PIDS+IHFGASTR+++IRERP  + N         +  A D S   N LP  E ELDNLT+FNTA NRR TS++    +       + +R S      VHF+D EE+INPED+DPS+GRFRNLVQETFIPNK       A +G ++  + ++    PP+  + + ++  +  ++ S       NP FS A KLGLPMPNLAP++D+      STF  LP+ T   S++ I     +  K++          DD     P+KKKYAKEAWPGK+P GF VGP
Sbjct:    9 LVNNFKIPSWAAKPPPGVHLDVMKDGKLIQKLMMDEKSCYFFGRNRQLCDFAIDHQSCSRIHAALVWHKNLNRAFLIDLGSVHGTFIGRIKLEPDRPQQVPIDSEIHFGASTRIFIIRERPNPLFNSSTAEADRVIKEAADASGNANKLPQSEVELDNLTQFNTAHNRRITSVVGEMQAPPPSAIQRGRRNSLNQRHSVHFSDIEEVINPEDVDPSVGRFRNLVQETFIPNKGTGRHEGADIGIAAPKVVSA----PPTPSNENAANQAVRQAAVS-------NPNFSLAVKLGLPMPNLAPDIDSAEPQDMSTFR-LPTTTTRLSAEDILGAPLSSVKDEITAGGKRPPADDVEKPGPKKKKYAKEAWPGKRP-GFLVGP 376
[Close]
BLAST of FHA domain-containing protein vs. TrEMBL
Match: W6UTD9 (Nuclear inhibitor of protein phosphatase OS=Echinococcus granulosus OX=6210 GN=EGR_08480 PE=4 SV=1)

HSP 1 Score: 358.221 bits (918), Expect = 7.545e-118
Identity = 202/386 (52.33%), Postives = 246/386 (63.73%), Query Frame = 3 
Query:   60 LTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNG--------LGRAEDLSFTGN-LPDDEEELDNLTEFNTAQNRRNTSIINMKDSKV------KRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDN------STFEALPSVTLVHSSQHITL-----------------DQTALNKNQDDE---PRKKKYAKEAWPGKKPVGFAVGP 1094
            L NNFKIP WA KPP G+HLDVMKDGKLIQKLM+D+K CYFFGRNRQLCDF IDHQS SR+H ALVWHK+L+R FLIDL SVHGTFIG I+LE  +PQQ+P+DS+IHFGASTR+Y+IRERP  + N         +  A D +   N LP  E ELDNLT+FNTA NRR  ++ +M+   V      +R S      VHF+D EE+INPED+DPSIGRFRNLVQETFIPNK + V        +   + A +  L P    P  S+    ++ S+    A  NP+F+ AAKLGLPMPNLAPE+D+      S    LP++     S    L                   TA +  ++ E   P+KKKYAKEAWPGK+P GF VGP
Sbjct:   37 LVNNFKIPSWAAKPPAGVHLDVMKDGKLIQKLMMDDKSCYFFGRNRQLCDFAIDHQSCSRIHAALVWHKNLNRAFLIDLGSVHGTFIGRIKLEPERPQQVPVDSEIHFGASTRVYIIRERPNPIINSSTAEADRLIKEAADATGNANKLPQSEVELDNLTQFNTAHNRR-IAVSDMQPPTVSAVQRGRRNSLNQRHSVHFSDIEEVINPEDVDPSIGRFRNLVQETFIPNKARLVPGADKHEGADIGIAAPKPSLTP----PTSSNTETATNQSTRSAAAVSNPSFTLAAKLGLPMPNLAPEIDSVEPQTASLLHRLPTMAATRLSAEDILGGPLPGPKEEGTTGAKRSATASSMGEEAESSAPKKKKYAKEAWPGKRP-GFLVGP 416
[Close]
BLAST of FHA domain-containing protein vs. TrEMBL
Match: A0A068Y859 (Nuclear inhibitor of protein phosphatase 1 OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000695700 PE=4 SV=1)

HSP 1 Score: 357.451 bits (916), Expect = 8.996e-118
Identity = 203/386 (52.59%), Postives = 246/386 (63.73%), Query Frame = 3 
Query:   60 LTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNG--------LGRAEDLSFTGN-LPDDEEELDNLTEFNTAQNRRNTSIINMKDSKV------KRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDN------STFEALPSVTLVHSSQHITL---------------DQTALNKNQDDE-----PRKKKYAKEAWPGKKPVGFAVGP 1094
            L NNFKIP WA KPP G+HLDVMKDGKLIQKLM+D+K CYFFGRNRQLCDF IDHQS SR+H ALVWHK+L+R FLIDL SVHGTFIG I+LE  +PQQ+PIDS+IHFGASTR+Y+IRERP  + N         +  A D +   N LP  E ELDNLT+FNTA NRR  ++ +M+   V      +R S      VHF+D EE+INPED+DPSIGRFRNLVQETFIPNK       A +G     + A +  L P    P  S+    ++ S+    A  NP+F+ AAKLGLPMPNLAPE+D+      S    LP++     S    L                ++A   +  +E     P+KKKYAKEAWPGK+P GF VGP
Sbjct:   24 LVNNFKIPSWAAKPPAGVHLDVMKDGKLIQKLMMDDKSCYFFGRNRQLCDFAIDHQSCSRIHAALVWHKNLNRAFLIDLGSVHGTFIGRIKLEPERPQQVPIDSEIHFGASTRVYIIRERPNPIINSSTAEADRLIKEAADATGNANKLPQSEVELDNLTQFNTAHNRR-IAVSDMQPPTVSAVQRGRRNSLNQRHSVHFSDIEEVINPEDVDPSIGRFRNLVQETFIPNKGADKHEGADIG-----IAAPKPSLTP----PTSSNTETATNQSTHSAAAVSNPSFTLAAKLGLPMPNLAPEIDSVEPQTASLLHRLPTMAAARLSAEDILGGPLPGPKEEGSTGAKRSAAASSMGEEAESSAPKKKKYAKEAWPGKRP-GFLVGP 398
[Close]
BLAST of FHA domain-containing protein vs. TrEMBL
Match: A0A504Z029 (Nuclear inhibitor of protein phosphatase OS=Fasciola gigantica OX=46835 GN=FGIG_05625 PE=4 SV=1)

HSP 1 Score: 357.066 bits (915), Expect = 1.247e-117
Identity = 202/407 (49.63%), Postives = 252/407 (61.92%), Query Frame = 3 
Query:   60 LTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNG-------------------LGRAEDLSFT---------GNLPDDEEELDNLTEFNTAQNRRNTSIINMK-------DSKVKRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQK-VSTVAPLGTSSYLMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEAL--PSVTLVHSSQH-----------------------ITLDQTALNKNQDDEPRKKKYAKEAWPGKKPVGFAVGPV 1097
            L NNFKIP WAGKPPPGLHLDVMKDGKLIQKL+IDEK CYFFGRN+QLCDF ++HQS SRVH  LVWHK L R FLIDL SVHGT+IG IRLEG +PQQ+PIDS++HFGASTR+Y+IRERP  + NG                   + R+ D S T          +LP  E ELDNLTEFNTA NRR   I+++          + KR  H     VHF+D +E+INPED+DPS+GRFRNLVQETFIPNKR K     A LG ++   T +R+   P+  +P        +++S     +   PA+S A KLGLP+PNLAP++D+ + E    P++ ++H+  H                       I   +T     + D P++KKYAKEAWPGK+P GF VGP 
Sbjct:   10 LVNNFKIPPWAGKPPPGLHLDVMKDGKLIQKLIIDEKSCYFFGRNKQLCDFAVEHQSCSRVHAVLVWHKFLSRAFLIDLGSVHGTYIGKIRLEGHRPQQVPIDSELHFGASTRIYIIRERPNPLYNGSNAGDGTGVGSDGLNSMGPVNRSLDDSGTDGASLGLLNSHLPQSEVELDNLTEFNTAHNRRIAGIVDVPANNSLGLGERRKRKLHS----VHFSDADEVINPEDVDPSVGRFRNLVQETFIPNKRAKGAHEGAFLGVAAPEATENRNQ--PT--NPRIVVNSTPTATSLLPSNSLFGPAYSVATKLGLPLPNLAPDIDSESTEPCLPPTLAMLHAHAHSRPGSLTAALPDGKQLGRLSANDILGTETESGLVEPDFPKRKKYAKEAWPGKRP-GFLVGPT 407
[Close]
BLAST of FHA domain-containing protein vs. TrEMBL
Match: A0A068WS37 (Nuclear inhibitor of protein phosphatase 1 OS=Echinococcus granulosus OX=6210 GN=EgrG_000695700 PE=4 SV=1)

HSP 1 Score: 357.066 bits (915), Expect = 1.360e-117
Identity = 204/387 (52.71%), Postives = 245/387 (63.31%), Query Frame = 3 
Query:   60 LTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNG--------LGRAEDLSFTGN-LPDDEEELDNLTEFNTAQNRRNTSIINMKDSKV------KRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRSDLP-PSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDN------STFEALPSVTLVHSSQHITL-----------------DQTALNKNQDDE---PRKKKYAKEAWPGKKPVGFAVGP 1094
            L NNFKIP WA KPP G+HLDVMKDGKLIQKLM+D+K CYFFGRNRQLCDF IDHQS SR+H ALVWHK+L+R FLIDL SVHGTFIG I+LE  +PQQ+P+DS+IHFGASTR+Y+IRERP  + N         +  A D +   N LP  E ELDNLT+FNTA NRR  ++ +M+   V      +R S      VHF+D EE+INPED+DPSIGRFRNLVQETFIPNK       A LG   +         P PS   P  S+    ++ S+    A  NP+F+ AAKLGLPMPNLAPE+D+      S    LP++     S    L                   TA +  ++ E   P+KKKYAKEAWPGK+P GF VGP
Sbjct:   24 LVNNFKIPSWAAKPPAGVHLDVMKDGKLIQKLMMDDKSCYFFGRNRQLCDFAIDHQSCSRIHAALVWHKNLNRAFLIDLGSVHGTFIGRIKLEPERPQQVPVDSEIHFGASTRVYIIRERPNPIINSSTAEADRLIKEAADATGNANKLPQSEVELDNLTQFNTAHNRR-IAVSDMQPPTVSAVQRGRRNSLNQRHSVHFSDIEEVINPEDVDPSIGRFRNLVQETFIPNK-------ARLGADKHEGADIGIAAPKPSLTPPTSSNTETATNQSTRSAAAVSNPSFTLAAKLGLPMPNLAPEIDSVEPQTASLLHRLPTMAATRLSAEDILGGPLPGPKEEGTTGAKRSATASSMGEEAESSAPKKKKYAKEAWPGKRP-GFLVGP 401
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Cavefish
Match: ppp1r8a (nuclear inhibitor of protein phosphatase 1-like [Source:NCBI gene;Acc:103022114])

HSP 1 Score: 288.115 bits (736), Expect = 8.721e-95
Identity = 171/355 (48.17%), Postives = 208/355 (58.59%), Query Frame = 3 
Query:   63 TNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPG---SMQNGLGRAEDLSFTG--NLPDDEEELDNLTEFNTAQNRRNTSIINMKDSKV---KRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLM---------TASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            T  F  P WAGKPPPGLHLDV+K  KLI+KL+IDEK+ Y FGRN   CDF IDHQS SRVH ALV+H+ L R FLIDL+S HGTF+G IRLE  KPQQ+PIDS + FGASTR+Y +RE+P    S   G G  ED    G   LP++E ELDNLTEFNTA N+R  S + +++  +   +    + +  V F++ EEIINPEDIDPS+GRFRN+VQ   +P K++K+   A LG     M         +    DLPP+  D             +    A      +    L LP PN APEVD S     P   L  +          LN     EPRKKKYAKEAWPGKKP 
Sbjct:    7 TAQFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKFYLFGRNPDHCDFTIDHQSCSRVHAALVYHRHLKRVFLIDLNSTHGTFLGRIRLEPHKPQQVPIDSTMSFGASTRVYTLREKPQTQPSAAAGDGGVEDEELKGLLGLPEEETELDNLTEFNTAHNKR-ISTLTIEEGNLDIQRPKRKRRSSRVSFSEDEEIINPEDIDPSVGRFRNMVQTAVVPLKKKKLEGHAALGLDDGAMRRMQNFPLSSGLYGDLPPTSHD-------------TGTPGAGGQGGSALLGGLPLPFPNPAPEVDLSPTTVPPPTMLNPTPAPGPYTAEPLN-----EPRKKKYAKEAWPGKKPT 342
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Cavefish
Match: ppp1r8a (nuclear inhibitor of protein phosphatase 1-like [Source:NCBI gene;Acc:103022114])

HSP 1 Score: 278.485 bits (711), Expect = 6.633e-91
Identity = 170/361 (47.09%), Postives = 208/361 (57.62%), Query Frame = 3 
Query:   57 NLTNNFKIPD----WAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPG---SMQNGLGRAEDLSFTG--NLPDDEEELDNLTEFNTAQNRRNTSIINMKDSKV---KRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLM---------TASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            NL     +P      AGKPPPGLHLDV+K  KLI+KL+IDEK+ Y FGRN   CDF IDHQS SRVH ALV+H+ L R FLIDL+S HGTF+G IRLE  KPQQ+PIDS + FGASTR+Y +RE+P    S   G G  ED    G   LP++E ELDNLTEFNTA N+R  S + +++  +   +    + +  V F++ EEIINPEDIDPS+GRFRN+VQ   +P K++K+   A LG     M         +    DLPP+  D             +    A      +    L LP PN APEVD S     P   L  +          LN     EPRKKKYAKEAWPGKKP 
Sbjct:   11 NLNGGLALPQDHGPVAGKPPPGLHLDVVKGDKLIEKLIIDEKKFYLFGRNPDHCDFTIDHQSCSRVHAALVYHRHLKRVFLIDLNSTHGTFLGRIRLEPHKPQQVPIDSTMSFGASTRVYTLREKPQTQPSAAAGDGGVEDEELKGLLGLPEEETELDNLTEFNTAHNKR-ISTLTIEEGNLDIQRPKRKRRSSRVSFSEDEEIINPEDIDPSVGRFRNMVQTAVVPLKKKKLEGHAALGLDDGAMRRMQNFPLSSGLYGDLPPTSHD-------------TGTPGAGGQGGSALLGGLPLPFPNPAPEVDLSPTTVPPPTMLNPTPAPGPYTAEPLN-----EPRKKKYAKEAWPGKKPT 352
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Cavefish
Match: ppp1r8b (protein phosphatase 1, regulatory subunit 8b [Source:ZFIN;Acc:ZDB-GENE-040426-1271])

HSP 1 Score: 242.276 bits (617), Expect = 4.877e-77
Identity = 137/267 (51.31%), Postives = 171/267 (64.04%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTGNLPDDEEELDN-------------LTEFNTAQNRRNTSIINMKDSK--VKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGT-------SSYLMTASRSDLPPSRDDPH 803
            F  P WAGKPPPGLHLDV+K  KL++KL+IDEK+ Y FGRN  LCDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQ+PIDS + FGASTR+Y IRE+P S  N +G       TG+   D+EEL               LTEFNTA N+R  S++ +++    + RP  K  +  V F + +EIINPEDIDPS+GRFRN++Q   +P K++K+ +   LG        S  L      DLPP+  D H
Sbjct:   12 FDCPSWAGKPPPGLHLDVVKGDKLVEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRLFLIDLNSTHGTFLGHIRLEPHKPQQVPIDSTMSFGASTRVYTIREKPQSQAN-VG-------TGDKAGDDEELKGLLGLPEEETELENLTEFNTAHNKR-ISVLTIEEGNLDIPRPKRKRKSSRVSFNEDDEIINPEDIDPSVGRFRNMIQTAVVPMKKKKMESGNVLGIEDSRHVQSFALRAGLYGDLPPTSHDAH 269
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Cavefish
Match: SNIP1 (Smad nuclear interacting protein 1 [Source:NCBI gene;Acc:103022573])

HSP 1 Score: 58.9214 bits (141), Expect = 3.051e-9
Identity = 32/97 (32.99%), Postives = 51/97 (52.58%), Query Frame = 3 
Query:  153 LMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGA----LVWHKDLH-------RPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            + I  +  Y  GR R++ D PIDH S S+ H      LV HK          +P++IDL S +GT++ + R+E  +  ++     + FG S+R YV+
Sbjct:  236 MYIHRQSAYLLGRQRKIADIPIDHPSCSKQHAVFQYRLVEHKRADGTTGRRVKPYIIDLGSGNGTYLNNQRIESQRYYELKEKDVLKFGFSSREYVL 332
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Cavefish
Match: slc4a1ap (solute carrier family 4 member 1 adaptor protein [Source:ZFIN;Acc:ZDB-GENE-080521-2])

HSP 1 Score: 55.0694 bits (131), Expect = 8.735e-8
Identity = 29/114 (25.44%), Postives = 62/114 (54.39%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIR 413
            +  P WAG        +++K+G ++  + + ++  +  GR   +CD  ++H S SR H A+V +++    ++ DL S HGTF+   ++      ++ +   + FG STR+++++
Sbjct:  169 YSEPPWAGVATVPYSFELLKNGAILDSIPLTQQSYFVVGR-LPVCDVSLEHPSISRYH-AVVQYREEAGFYVYDLGSTHGTFLNKNKIPPKTYIRLRVGHVLKFGGSTRLFILQ 280
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Sea Lamprey
Match: ppp1r8a (protein phosphatase 1, regulatory subunit 8a [Source:ZFIN;Acc:ZDB-GENE-060503-681])

HSP 1 Score: 142.124 bits (357), Expect = 7.638e-40
Identity = 106/284 (37.32%), Postives = 151/284 (53.17%), Query Frame = 3 
Query:  282 FLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTG--------NLPDDEEELDNLTEFNTAQNRR-NTSIINMKDSKVKRPS-HKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKL-GLPMPNLAPEVDNSTF---EALPSVTLVHSSQHITLDQTALNKNQDDEP-----RKKKYAKEAWPGKKPV 1076
            +L+ +++ HG+F+G IRLE  KPQQ+P+D+ + FGASTR Y +RERP ++  G     +              LP++E ELDNLT+FNTA N+R  T  I   +  + RP   + + +V F++ EE+INPEDIDPS+GRFRN++Q   +P KR++     P  TS    ++ R    P      YS +    S       +A+ P   A A + GLP+P   P  D   F   +  P++    ++        A       EP     RKKKYAKEAWPGKKP 
Sbjct:    2 YLVTVAA-HGSFLGQIRLEPHKPQQVPVDTTLTFGASTRTYTLRERPQTLPGGATGKGEEKNEEEEMKGGLLGLPEEETELDNLTDFNTAHNKRIATLTIEEGNLDLPRPKRRRRSFHVSFSEDEEVINPEDIDPSVGRFRNMIQTAVVPLKRKQDGPGTP--TSPGDSSSKRLHGFPFSSG-LYSGIPGGESGMPPTSPSALGPGAGATALIGGLPLPLPNPAPDVEVFPEQDPAPNLNSASAAAAAAAAAAATAAAAAPEPGPTLPRKKKYAKEAWPGKKPT 281
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Nematostella
Match: EDO47533 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RM34])

HSP 1 Score: 241.891 bits (616), Expect = 5.656e-77
Identity = 143/363 (39.39%), Postives = 194/363 (53.44%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERP----GSMQNGLGRAEDLSFTG---NLPDDEEELDNLTEFNTAQNRRNTSI------INMKDSKVKRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQET-FIPNKRQKVSTVAPLGTSSYLMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLP-MPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQD-------------DEPRKKKYAKEAWPGKKPV 1076
            +++P WAGKP  GLHLDVMK  KL++KL+ID K CY FGRN+ +CDF ++H S SRVH ALV+H+ L R FL+DL S HGT+IG+IR+E  KP Q+ +DS I FGASTR Y +RE+P    G +  G G     S TG    LP+ + ELD+LTEFNTA N+R  S+       ++      +   +A+  V F D EEIINPED+DPS+G+FRN+V  +  +P K+ + +      T +  +T    + P                             +S      LP      P    S   +LP + +  + + I+ DQ  +N                  E  KKKYAKEAWPGKKP 
Sbjct:   27 YQVPSWAGKPTQGLHLDVMKMDKLVEKLIIDGKPCYLFGRNKDVCDFMVEHSSCSRVHAALVFHRHLKRCFLVDLGSTHGTYIGTIRIERNKPTQVQVDSVIRFGASTRTYTLREKPTGSGGKVDKGDGDISQDSTTGGLLGLPESDTELDDLTEFNTAHNKRLASVGLEESTSSLSSLSSLKRKRRASHIVAFKDVEEIINPEDVDPSVGKFRNMVHTSVVVPTKKMRGAGPGGGPTMTENITKRLQNFP-----------------------------YSQGLYTNLPSATGEEPTSPTSPTASLPKLNITSAPEVISPDQQQINIEPQPSVVQPVAMPGVPAEAPKKKYAKEAWPGKKPT 360
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Nematostella
Match: EDO32995 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STE9])

HSP 1 Score: 60.4622 bits (145), Expect = 6.177e-10
Identity = 36/121 (29.75%), Postives = 62/121 (51.24%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPG--LHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWH-----KDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIR 413
            +K P W+G    G    L+++K+G +I  L +  K  Y FGR    CD  ++H S SR H  + +      K     +L DL S HGT +  + ++  K  ++ +   I FG S+R+++++
Sbjct:   55 YKEPTWSGLVDNGENYSLELLKNGCIISTLDLTSKPYYLFGRLPN-CDVVMEHPSVSRYHAIIQYKAGQTSKSDQGFYLYDLGSTHGTMVNKVPIDPKKYYRLRVGYVIKFGGSSRLFILQ 174
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Nematostella
Match: EDO38224 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDH1])

HSP 1 Score: 55.8398 bits (133), Expect = 1.706e-9
Identity = 35/137 (25.55%), Postives = 62/137 (45.26%), Query Frame = 3 
Query:   33 SRYEAIAQNLTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLH-----------RPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            + Y    + +   +  P  A KP     L   K  + +  + I  +  Y  GR R + D PIDH S S+ H  L +    +           +P+++DL S +GTF+ + ++E  +  ++     + FG S+R YV+
Sbjct:   25 TEYTNTYKGVVIKYNEPPEARKPNTRWRLYPFKGEESLPVMYIHRQSAYLLGRQRHIADIPIDHPSCSKQHAILQYRLVNYEKPDGSKGRRVKPYVLDLDSANGTFLNNQKVEPRRYYELKERDVLKFGFSSREYVL 161
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Medaka
Match: ppp1r8b (protein phosphatase 1 regulatory subunit 8 [Source:NCBI gene;Acc:111948964])

HSP 1 Score: 290.812 bits (743), Expect = 8.504e-96
Identity = 174/357 (48.74%), Postives = 214/357 (59.94%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERP---GSMQNG---LGRAEDLSFTGNLPDDEEELDNLTEFNTAQNRRNTSIINMKDS--KVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASR-----------SDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPM--PNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPV 1076
            F  P WAGKPP GLHLDVMK  KLI+KL+IDEK+ Y FGRN   CDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQ+PIDS + FGASTR Y+IRE+P   GS   G    G  E+L     LP++E ELDNLTEFNTA N+R  S++ +++   +++RP  K  N  V F++++ IINPEDIDPS+GRFRN+VQ   IP K+++      LG     +TA R            DLPP+  +                          AA + GLP+  PN APEVD +     P ++L  +          LN     EPRKKKYAKEAWPGKKP 
Sbjct:   13 FDCPSWAGKPPTGLHLDVMKGDKLIEKLIIDEKKFYLFGRNPDWCDFTIDHQSCSRVHAALVYHKHLKRLFLIDLNSTHGTFLGHIRLEAHKPQQVPIDSTLAFGASTRTYIIREKPQTQGSTSTGDNKTGDDEELKGLLGLPEEETELDNLTEFNTAHNKR-ISLLTIEEGNLEIQRPKRKRRNSRVTFSEEDSIINPEDIDPSVGRFRNMVQTAVIPIKKRRAEGQNTLGLDE--LTAKRMHGYSLGGGLYGDLPPTSHE-----------------NQPTGAPGGAAMQGGLPLPFPNPAPEVDLAPEAPHPPISLNPTPVTAPYLPETLN-----EPRKKKYAKEAWPGKKPT 344
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Medaka
Match: ppp1r8b (protein phosphatase 1 regulatory subunit 8 [Source:NCBI gene;Acc:111948964])

HSP 1 Score: 265.774 bits (678), Expect = 1.526e-85
Identity = 163/350 (46.57%), Postives = 205/350 (58.57%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERP---GSMQNG---LGRAEDLSFTGNLPDDEEELDNLTEFNTAQNRRNTSIINMKDS--KVKRPSHK-ANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASR-----------SDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPM--PNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEA 1055
            F  P WAGKPP GLHLDVMK  KLI+KL+IDEK+ Y FGRN   CDF IDHQS SRVH ALV+HK L R FLIDL+S HGTF+G IRLE  KPQQ+PIDS + FGASTR Y+IRE+P   GS   G    G  E+L     LP++E ELDNLTEFNTA N+R  S++ +++   +++RP  K  N  V F++++ IINPEDIDPS+GRFRN+VQ   IP K+++      LG     +TA R            DLPP+  +                          AA + GLP+  PN APEVD +     P ++L  +          LN     EPRKKK  ++ 
Sbjct:   13 FDCPSWAGKPPTGLHLDVMKGDKLIEKLIIDEKKFYLFGRNPDWCDFTIDHQSCSRVHAALVYHKHLKRLFLIDLNSTHGTFLGHIRLEAHKPQQVPIDSTLAFGASTRTYIIREKPQTQGSTSTGDNKTGDDEELKGLLGLPEEETELDNLTEFNTAHNKR-ISLLTIEEGNLEIQRPKRKRRNSRVTFSEEDSIINPEDIDPSVGRFRNMVQTAVIPIKKRRAEGQNTLGLDE--LTAKRMHGYSLGGGLYGDLPPTSHE-----------------NQPTGAPGGAAMQGGLPLPFPNPAPEVDLAPEAPHPPISLNPTPVTAPYLPETLN-----EPRKKKLPEDG 337
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Medaka
Match: SNIP1 (Smad nuclear interacting protein 1 [Source:NCBI gene;Acc:101173889])

HSP 1 Score: 57.3806 bits (137), Expect = 8.194e-9
Identity = 28/97 (28.87%), Postives = 50/97 (51.55%), Query Frame = 3 
Query:  153 LMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLH-----------RPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            + +  +  Y  GR R++ D PIDH S S+ H    +    +           RP++IDL+S +GT++ + R+E  +  ++     + FG S+R YV+
Sbjct:  235 MYVHRQSAYLLGRQRKIADIPIDHPSCSKQHAVFQYRLVQYTRADGTTGRRVRPYIIDLASGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVL 331
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Medaka
Match: SNIP1 (Smad nuclear interacting protein 1 [Source:NCBI gene;Acc:101173889])

HSP 1 Score: 57.3806 bits (137), Expect = 8.774e-9
Identity = 28/97 (28.87%), Postives = 50/97 (51.55%), Query Frame = 3 
Query:  153 LMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLH-----------RPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            + +  +  Y  GR R++ D PIDH S S+ H    +    +           RP++IDL+S +GT++ + R+E  +  ++     + FG S+R YV+
Sbjct:  235 MYVHRQSAYLLGRQRKIADIPIDHPSCSKQHAVFQYRLVQYTRADGTTGRRVRPYIIDLASGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVL 331
[Close]
BLAST of FHA domain-containing protein vs. Ensembl Medaka
Match: slc4a1ap (solute carrier family 4 member 1 adaptor protein [Source:NCBI gene;Acc:101169402])

HSP 1 Score: 49.6766 bits (117), Expect = 4.595e-6
Identity = 31/124 (25.00%), Postives = 58/124 (46.77%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLH-LDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDL--------HRPFLI-DLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIR 413
            +  P W G P    + L+++K+G ++  + +     +  GR   +CD  ++H S SR H  + +             R F I DL S HGT +   ++      ++ +   + FG STR++V++
Sbjct:  141 YTEPLWGGSPSDAQYALEILKNGAIVDTVPLSHSSFFVVGR-LPVCDVSLEHPSISRYHAVIQYRSQAGQEGCVGEERGFYIHDLGSTHGTVVNKNKIPPKTYIRLRVGHVLKFGGSTRLFVLQ 263
[Close]
BLAST of FHA domain-containing protein vs. Planmine SMEST
Match: SMESG000055731.1 (SMESG000055731.1)

HSP 1 Score: 706.057 bits (1821), Expect = 0.000e+0
Identity = 358/358 (100.00%), Postives = 358/358 (100.00%), Query Frame = 3 
Query:   24 MSKSRYEAIAQNLTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTGNLPDDEEELDNLTEFNTAQNRRNTSIINMKDSKVKRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRSDLPPSRDDPHYXXXXXXXXXXXXXXXXAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPVGFAVGPV 1097
            MSKSRYEAIAQNLTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTGNLPDDEEELDNLTEFNTAQNRRNTSIINMKDSKVKRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRSDLPPSRDDPHYSSLLMTSSSSSAHHMAAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPVGFAVGPV
Sbjct:    1 MSKSRYEAIAQNLTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTGNLPDDEEELDNLTEFNTAQNRRNTSIINMKDSKVKRPSHKANLYVHFTDQEEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRSDLPPSRDDPHYSSLLMTSSSSSAHHMAAINPAFSAAAKLGLPMPNLAPEVDNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKPVGFAVGPV 358
[Close]
BLAST of FHA domain-containing protein vs. Planmine SMEST
Match: SMESG000021239.1 (SMESG000021239.1)

HSP 1 Score: 64.6994 bits (156), Expect = 4.999e-12
Identity = 41/129 (31.78%), Postives = 65/129 (50.39%), Query Frame = 3 
Query:   45 AIAQNLTNNFKI----PDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLH---RPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            A   N+    KI    P  A  P     L   K  + +  + +  +  Y  G++R +C+ P+DH S S+ H A++  + L    RP+LIDL S +G+FI  I++E  K  ++     + FG STR YV+
Sbjct:   55 AEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQH-AVIQFRQLDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 182
[Close]
BLAST of FHA domain-containing protein vs. Planmine SMEST
Match: SMESG000074111.1 (SMESG000074111.1)

HSP 1 Score: 65.4698 bits (158), Expect = 2.420e-11
Identity = 39/120 (32.50%), Postives = 61/120 (50.83%), Query Frame = 3 
Query:   72 FKIPDWAGKPPPGLH-LDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVW------HKDLHRPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 410
            +K P W+G      + LDV+K+G +I+ + ++EK  Y  GR +  CD   DH S SR H  L +       K     +L+DL S HGT +   ++      ++     I FG STR+Y++
Sbjct:   15 YKEPKWSGICNDHEYGLDVLKNGVIIENIKLNEKPYYIVGRYK-TCDLIFDHPSLSRFHSVLQYCSSDNEEKKEKGWYLMDLDSTHGTIVNKKKIPSHTFIRVHTGHVIKFGGSTRLYIV 133
The following BLAST results are available for this feature:
BLAST of FHA domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PPP1R87.549e-9546.39protein phosphatase 1 regulatory subunit 8 [Source... [more]
PPP1R86.944e-3136.24protein phosphatase 1 regulatory subunit 8 [Source... [more]
PPP1R87.168e-3136.24protein phosphatase 1 regulatory subunit 8 [Source... [more]
SNIP12.934e-827.42Smad nuclear interacting protein 1 [Source:HGNC Sy... [more]
SLC4A1AP2.880e-727.42solute carrier family 4 member 1 adaptor protein [... [more]
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BLAST of FHA domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
B0511.71.317e-5637.24pep chromosome:WBcel235:I:10631665:10633150:-1 gen... [more]
C32E8.54.850e-1028.17pep chromosome:WBcel235:I:3782118:3783232:1 gene:W... [more]
C32E8.54.850e-1028.17pep chromosome:WBcel235:I:3782118:3783294:1 gene:W... [more]
ZK632.27.197e-627.27pep chromosome:WBcel235:III:9799107:9802333:1 gene... [more]
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BLAST of FHA domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
NiPp11.855e-8942.71gene:FBgn0026402 transcript:FBtr0087058[more]
CG171684.640e-1030.65gene:FBgn0039943 transcript:FBtr0113730[more]
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BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ppp1r8a5.570e-8747.09protein phosphatase 1, regulatory subunit 8a [Sour... [more]
ppp1r8b3.687e-7946.33protein phosphatase 1, regulatory subunit 8b [Sour... [more]
ppp1r8b4.107e-7946.33protein phosphatase 1, regulatory subunit 8b [Sour... [more]
snip11.611e-728.87Smad nuclear interacting protein [Source:ZFIN;Acc:... [more]
snip13.684e-728.87Smad nuclear interacting protein [Source:ZFIN;Acc:... [more]
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BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ak62.543e-9647.03adenylate kinase 6 [Source:Xenbase;Acc:XB-GENE-972... [more]
ak61.634e-9447.70adenylate kinase 6 [Source:Xenbase;Acc:XB-GENE-972... [more]
ak68.462e-9347.41adenylate kinase 6 [Source:Xenbase;Acc:XB-GENE-972... [more]
snip12.792e-928.23Smad nuclear interacting protein 1 [Source:NCBI ge... [more]
alkbh73.754e-825.30alkB homolog 7 [Source:Xenbase;Acc:XB-GENE-958693][more]
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BLAST of FHA domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ppp1r81.112e-9546.39protein phosphatase 1, regulatory subunit 8 [Sourc... [more]
Ppp1r86.139e-9446.11protein phosphatase 1, regulatory subunit 8 [Sourc... [more]
Slc4a1ap6.751e-927.42solute carrier family 4 (anion exchanger), member ... [more]
Slc4a1ap7.669e-927.42solute carrier family 4 (anion exchanger), member ... [more]
Slc4a1ap8.101e-927.42solute carrier family 4 (anion exchanger), member ... [more]
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BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8R3G1|PP1R8_MOUSE7.777e-9546.39Nuclear inhibitor of protein phosphatase 1 OS=Mus ... [more]
sp|Q12972|PP1R8_HUMAN3.625e-9446.39Nuclear inhibitor of protein phosphatase 1 OS=Homo... [more]
sp|Q28147|PP1R8_BOVIN8.173e-9446.13Nuclear inhibitor of protein phosphatase 1 OS=Bos ... [more]
sp|Q9FIK2|PP1R8_ARATH3.755e-2430.08Protein phosphatase 1 regulatory inhibitor subunit... [more]
sp|Q8W4D8|DDL_ARATH2.701e-1131.75FHA domain-containing protein DDL OS=Arabidopsis t... [more]
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BLAST of FHA domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0R3UPT31.020e-11953.28FHA domain-containing protein OS=Mesocestoides cor... [more]
W6UTD97.545e-11852.33Nuclear inhibitor of protein phosphatase OS=Echino... [more]
A0A068Y8598.996e-11852.59Nuclear inhibitor of protein phosphatase 1 OS=Echi... [more]
A0A504Z0291.247e-11749.63Nuclear inhibitor of protein phosphatase OS=Fascio... [more]
A0A068WS371.360e-11752.71Nuclear inhibitor of protein phosphatase 1 OS=Echi... [more]
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BLAST of FHA domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ppp1r8a8.721e-9548.17nuclear inhibitor of protein phosphatase 1-like [S... [more]
ppp1r8a6.633e-9147.09nuclear inhibitor of protein phosphatase 1-like [S... [more]
ppp1r8b4.877e-7751.31protein phosphatase 1, regulatory subunit 8b [Sour... [more]
SNIP13.051e-932.99Smad nuclear interacting protein 1 [Source:NCBI ge... [more]
slc4a1ap8.735e-825.44solute carrier family 4 member 1 adaptor protein [... [more]
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BLAST of FHA domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ppp1r8a7.638e-4037.32protein phosphatase 1, regulatory subunit 8a [Sour... [more]
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BLAST of FHA domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FHA domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO475335.656e-7739.39Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO329956.177e-1029.75Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO382241.706e-925.55Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of FHA domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ppp1r8b8.504e-9648.74protein phosphatase 1 regulatory subunit 8 [Source... [more]
ppp1r8b1.526e-8546.57protein phosphatase 1 regulatory subunit 8 [Source... [more]
SNIP18.194e-928.87Smad nuclear interacting protein 1 [Source:NCBI ge... [more]
SNIP18.774e-928.87Smad nuclear interacting protein 1 [Source:NCBI ge... [more]
slc4a1ap4.595e-625.00solute carrier family 4 member 1 adaptor protein [... [more]
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BLAST of FHA domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000055731.10.000e+0100.00SMESG000055731.1[more]
SMESG000021239.14.999e-1231.78SMESG000021239.1[more]
SMESG000074111.12.420e-1132.50SMESG000074111.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008121 ID=SMED30008121|Name=FHA domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1166bp
CTTAATTTTGAATTTTTAAAATAATGTCAAAATCCAGATATGAAGCAATT
GCACAGAATTTAACTAATAATTTTAAAATTCCAGATTGGGCAGGAAAACC
TCCACCAGGTTTGCATTTAGATGTTATGAAAGATGGTAAATTAATACAAA
AATTAATGATTGACGAAAAAAGGTGTTATTTTTTTGGACGCAATCGACAA
TTATGTGATTTTCCAATTGATCATCAATCCGGTTCACGGGTACATGGAGC
ATTAGTTTGGCATAAAGATTTGCACCGGCCATTTTTAATTGATCTTAGTA
GTGTTCATGGAACATTTATCGGCAGTATAAGATTAGAAGGCGGGAAACCT
CAGCAAATTCCCATCGATTCTAAAATACATTTCGGTGCCAGTACTAGAAT
GTATGTCATTAGAGAGCGGCCTGGCTCAATGCAGAATGGACTTGGACGGG
CTGAGGATTTGAGTTTTACTGGCAACCTGCCGGATGATGAAGAAGAGCTT
GACAATCTGACGGAGTTCAACACAGCCCAGAACCGCCGGAACACGTCAAT
AATCAACATGAAGGACAGCAAAGTGAAACGGCCGTCCCACAAGGCCAATC
TCTATGTACATTTCACCGACCAGGAGGAGATAATCAATCCCGAAGATATC
GATCCATCGATTGGTCGTTTCCGCAATCTCGTCCAGGAGACCTTTATACC
AAATAAGCGCCAGAAAGTGTCGACAGTCGCACCCTTGGGAACCAGCAGCT
ACCTGATGACGGCCTCGAGATCCGACCTGCCGCCCTCCAGGGATGATCCC
CATTACTCCAGCCTTCTAATGACGTCATCTTCATCATCAGCCCATCACAT
GGCTGCAATCAATCCGGCATTTTCCGCGGCTGCCAAGCTCGGCCTCCCAA
TGCCCAATCTGGCACCAGAGGTAGACAATTCCACCTTCGAGGCCCTGCCC
AGCGTCACCTTGGTGCACAGCTCGCAACACATCACTCTCGATCAGACTGC
GCTCAACAAGAATCAGGACGACGAACCGCGAAAAAAGAAATATGCCAAAG
AAGCCTGGCCCGGAAAGAAACCGGTCGGATTCGCTGTTGGTCCCGTCTGA
GAGAGAGCGCTTGTACATAATTTATTTGCAGTTCAATATAATTATTTTTT
ATCTTTTCAAAAAAAA
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protein sequence of SMED30008121-orf-1

>SMED30008121-orf-1 ID=SMED30008121-orf-1|Name=SMED30008121-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=359bp
MSKSRYEAIAQNLTNNFKIPDWAGKPPPGLHLDVMKDGKLIQKLMIDEKR
CYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLHRPFLIDLSSVHGTFIG
SIRLEGGKPQQIPIDSKIHFGASTRMYVIRERPGSMQNGLGRAEDLSFTG
NLPDDEEELDNLTEFNTAQNRRNTSIINMKDSKVKRPSHKANLYVHFTDQ
EEIINPEDIDPSIGRFRNLVQETFIPNKRQKVSTVAPLGTSSYLMTASRS
DLPPSRDDPHYSSLLMTSSSSSAHHMAAINPAFSAAAKLGLPMPNLAPEV
DNSTFEALPSVTLVHSSQHITLDQTALNKNQDDEPRKKKYAKEAWPGKKP
VGFAVGPV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0032515negative regulation of phosphoprotein phosphatase activity
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0006397mRNA processing
GO:0007275multicellular organism development
GO:0008283cell proliferation
GO:0008380RNA splicing
GO:0035308negative regulation of protein dephosphorylation
GO:0043086negative regulation of catalytic activity
GO:0050790regulation of catalytic activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR027310Profilin_CS
IPR000253FHA_dom
IPR008984SMAD_FHA_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0003779actin binding
GO:0005515protein binding
GO:0003677DNA binding
GO:0003723RNA binding
GO:0003729mRNA binding
GO:0004864protein phosphatase inhibitor activity
GO:0004865protein serine/threonine phosphatase inhibitor activity
GO:0019888protein phosphatase regulator activity
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005681spliceosomal complex
GO:0016607nuclear speck
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000253Forkhead-associated (FHA) domainSMARTSM00240FHA_2coord: 51..104
e-value: 6.4E-10
score: 49.0
IPR000253Forkhead-associated (FHA) domainPFAMPF00498FHAcoord: 52..121
e-value: 3.7E-11
score: 43.2
IPR000253Forkhead-associated (FHA) domainPROSITEPS50006FHA_DOMAINcoord: 52..104
score: 11.488
IPR000253Forkhead-associated (FHA) domainCDDcd00060FHAcoord: 30..122
e-value: 7.68598E-15
score: 67.7966
NoneNo IPR availableGENE3DG3DSA:2.60.200.20coord: 2..135
e-value: 1.1E-32
score: 114.6
NoneNo IPR availablePANTHERPTHR23308:SF28NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE 1coord: 11..350
NoneNo IPR availablePANTHERPTHR23308NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1coord: 11..350
IPR008984SMAD/FHA domain superfamilySUPERFAMILYSSF49879SMAD/FHA domaincoord: 13..131