TPR repeat-containing protein DDB_G0287407 isoform X2

Overview
NameTPR repeat-containing protein DDB_G0287407 isoform X2
Smed IDSMED30008115
Length (bp)6122
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TPR repeat-containing protein DDB_G0287407 isoform X2 (SMED30008115) t-SNE clustered cells

Violin plots show distribution of expression levels for TPR repeat-containing protein DDB_G0287407 isoform X2 (SMED30008115) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TPR repeat-containing protein DDB_G0287407 isoform X2 (SMED30008115) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TPR repeat-containing protein DDB_G0287407 isoform X2 (SMED30008115) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30008115

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30008115h1SMcG0014821 SmedASXL_018490SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
protonephridiaSMED30008115h1SMcG0014821 dd_Smed_v4_12326_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30008115h1SMcG0014821 dd_Smed_v4_12326_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30008115h1SMcG0014821 dd_Smed_v4_12326_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30008115h1SMcG0014821 dd_Smed_v4_12326_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30008115h1SMcG0014821 dd_Smed_v6_12326_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Zebrafish
Match: ttc41 (tetratricopeptide repeat domain 41 [Source:ZFIN;Acc:ZDB-GENE-110914-190])

HSP 1 Score: 86.6557 bits (213), Expect = 2.417e-16
Identity = 110/438 (25.11%), Postives = 190/438 (43.38%), Query Frame = 2
Query:  320 VSINLDSIKQNGSISICLLGENFER-LPKLYEDIGYDYPEFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFR--------VSGGPISDDDDGNEN-----EIESKQPSSENDRMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDF--YRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQS-KTKNTDVICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSLETEMLSLSQKFLGAMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFK-RTDIAIIEVLP 1579
            + I+LD + ++ S  ICLLG ++ + LP    DI       +   L IAA SGYPW+   +     S+ E+       +   +   FYF+               +DDDG+E      ++ SKQ   E  R+ +LK+ +I   LP++F+ +  E  +  RKD    +E    KIS             KD   + +  ++   + S   S   +L  W +      P     E LN F  +    +          N   L +   +  +  +LV++G RG GKS++    LQ+   +N D+  I ++C  S +S+D++ +L     ++R    +N +  D++     T       + + A   A N+   +L+I             S +++KS  W+P V+P   ++IIT+T +D  L    F  RTD+ I++  P
Sbjct:   27 LKISLDLVDRS-SFFICLLGHSYGQCLP----DIESCSSSEVVRKLNIAASSGYPWVLE-DEYRTCSLTELEITKAAFIDNHRLCFFYFKDYTPQDTEDDDDDDDNDDDGSEEMSIFLDMLSKQSQRERQRLRDLKRRIINHCLPVRFFRNQYELGEMIRKD----WEEVISKIS-------------KDSKHLISGWQDSFDLHSH-KSYSRALCNWFV------PSVPATETLNAFDKFLHPVTHNAKYETHAKNPGALFNSDLNDSEKSVLVISGERGCGKSTLAAWCLQTFSEQNPDLPVIRHFCGTSTSSTDVRSLLRLCTAQLRK--AHNGDSPDWDESLENTSEFEYLHRAVQAFTAALNLRPCILLIDGIDLLTET-LGLSKQEVKSLQWLPAVLPPFCKMIITTTFTD--LTHKSFSCRTDVQILKCPP 429          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Xenopus
Match: ccnol.13 (Putative ortholog of g2/mitotic-specific cyclin B3, 13 of 14 [Source:Xenbase;Acc:XB-GENE-940407])

HSP 1 Score: 100.138 bits (248), Expect = 2.980e-20
Identity = 118/502 (23.51%), Postives = 213/502 (42.43%), Query Frame = 2
Query:  140 PFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCFDLIYP-NPKPMDILSNPLKDFVSINLDSIKQNGSISICLLGENF-ERLPKLYEDIGY------DYPEF--LENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIESKQPS--SEND----RMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFER-FPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKL---SVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQS-KTKNTDVICIPYYCEASYASSDLQKMLNSLIKRIRLDCGY-NLEQDDYETYSLETEMLS---LSQKFLGAMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIE 1570
            P++ S+  DF  E N +   IF  +  + + +   S    DL +P   +P  +    + + ++++LD I+++    IC+LG  + E +P+ +           D+     +E  L +AA+SGY W+    N +  S+ E+   +     ++ +  FYFR            NE E ++   +  SEND    ++  LK  ++ +G P++F+ +  E      KD  DI ER +P                 K+     +      K F+E       L K  +    SN   ++  +L+DF     ++K    S+    ++   L + +       ILVL G RG GKS+I   W  S +T N D+  I Y+  +S  SS++   +   I    L C Y  ++ +D       T+M +   L + FL  + L   +     I      +         +Q K   W+P  +P+  +II+T++ +  S   +K  R+D+ + E
Sbjct:   17 PYVCSTIKDFQEERNYLSKNIFEQLNDFCYARG-TSFKAVDLRWPLEGQPYHVKPFNVAEQLTLSLDYIERSSPFFICILGHTYGEFIPEAHSHCPINSVSISDFSALPNVEQKLVVAANSGYSWLLEGGNRE-CSITELEIHHAAFSRDVGFQYFYFRDHVCIEEQLHKANEEEKKTILSTFESENDYERTKIWELKIRIVDKGFPVRFFKTKEELGNLVLKDWCDIIERLYP------------LSATPKNIGHEHSLQHAYNKAFAE------CLCKDFVPTEQSN---KLLTVLDDFVFGAQAEKQSTHSLGSESIDCDVLHNTAARSGAASILVLYGDRGCGKSTIAAKWFNSFRTNNPDITVISYFVGSSGRSSNIMSFMRYCI--TVLQCEYFGVQAEDLMNNENSTDMWAFPLLLEVFLSCITLKPCVLLLDGIDGLSGIN-----GIPAEQAKGFLWLPVNLPDYCKIILTTSPTHLSFKCLKV-RSDVVLAE 487          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Mouse
Match: Ttc41 (tetratricopeptide repeat domain 41 [Source:MGI Symbol;Acc:MGI:2387653])

HSP 1 Score: 70.4774 bits (171), Expect = 1.605e-11
Identity = 119/515 (23.11%), Postives = 209/515 (40.58%), Query Frame = 2
Query:  137 FPFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCFDLIYPNPKPM-DILSNPLKDF-------VSINLDSIKQNGSISICLLGENFERLPKLYEDIGYDYPEFL-------------ENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPI---SDDDDGNENEIESKQPSSENDRME--NLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSV--TIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQS-KTKNTDVICIPYYCEASYASSDLQKMLNSLIKRI-------RLDCGYNLEQDDYETYSLETEMLSLSQKFLGAMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEV 1573
             P+I S+  DF  E + +   IFP +      +  +     DL +   K      SN  + +       + ++LD + +     I LLG+        Y D   DY  FL             E +L IAA +GYPW+    N    S+ E          + ++  FYFR S   +   +++++  E ++ S    +E  +M+   LK  +I +GLP++FY    E      KD   + E+          M       + + L    F EN K++F             T  E+N     R  E+L  F  KD    L    TI      ++  I++      IL+L+G RG GKS+++ NW+ + ++K+  V+ IPY+  ++  S D+  +++  +  +       RL+  +  E  +   +SL  E+   +      +L+   I   + I              S ++ K   W+P  +P + +  I S+ S S   +    R D+ I+E+
Sbjct:   25 LPYICST-LDFQEERDFLAKSIFPRLNDICSSRGTY-FKAVDLRWSAVKAHKSFTSNQFRQYSCLQSQHLKLSLDYVNRCFPFFIGLLGQT-------YGDFLPDYTPFLLSQVKDFESLSKGEQNLYIAAKNGYPWVLKTPN---CSLTEFEIIQAVFRKKSQFQFFYFRTSNSLLRTFNEEEEEEEEKLSSAYLLNEQGKMKVGKLKAKIIGKGLPVRFYRDLEELGDMVWKDWSAVVEKL---YPFTTIMGNIDYKHSFENLYHEEFVENCKQVFV------------TSKESN-----RTFEILERFAIKDLDLDLDTDSTIAGSGLDSILRINSLPTCKSILLLSGERGCGKSTLIANWVSNFQSKHPGVLMIPYFVGSTCESCDIMSVIHYFVMELQHRANGPRLEMDFLNEDSNVLVFSLLVEVFIAAISLKPCILVLDGIEELIGIY-----------GISGQKAKDFSWLPRSLPPHCK-FILSSVSSSLSCKSLCARPDVKIVEL 495          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Mouse
Match: Ttc41 (tetratricopeptide repeat domain 41 [Source:MGI Symbol;Acc:MGI:2387653])

HSP 1 Score: 70.4774 bits (171), Expect = 2.579e-11
Identity = 122/521 (23.42%), Postives = 212/521 (40.69%), Query Frame = 2
Query:  137 FPFIISSGDDFTYELNAIKNEIFP------SVKSYYFPKKHFSVNCFDLIYPNPKPM-DILSNPLKDF-------VSINLDSIKQNGSISICLLGENFERLPKLYEDIGYDYPEFL-------------ENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPI---SDDDDGNENEIESKQPSSENDRME--NLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSV--TIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQS-KTKNTDVICIPYYCEASYASSDLQKMLNSLIKRI-------RLDCGYNLEQDDYETYSLETEMLSLSQKFLGAMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEV 1573
             P+I S+  DF  E + +   IFP      S +  YF          DL +   K      SN  + +       + ++LD + +     I LLG+        Y D   DY  FL             E +L IAA +GYPW+    N    S+ E          + ++  FYFR S   +   +++++  E ++ S    +E  +M+   LK  +I +GLP++FY    E      KD   + E+          M       + + L    F EN K++F             T  E+N     R  E+L  F  KD    L    TI      ++  I++      IL+L+G RG GKS+++ NW+ + ++K+  V+ IPY+  ++  S D+  +++  +  +       RL+  +  E  +   +SL  E+   +      +L+   I   + I              S ++ K   W+P  +P + + I++S +S  S  +    R D+ I+E+
Sbjct:   25 LPYICST-LDFQEERDFLAKSIFPRLNDICSSRGTYF-------KAVDLRWSAVKAHKSFTSNQFRQYSCLQSQHLKLSLDYVNRCFPFFIGLLGQT-------YGDFLPDYTPFLLSQVKDFESLSKGEQNLYIAAKNGYPWVLKTPN---CSLTEFEIIQAVFRKKSQFQFFYFRTSNSLLRTFNEEEEEEEEKLSSAYLLNEQGKMKVGKLKAKIIGKGLPVRFYRDLEELGDMVWKDWSAVVEKL---YPFTTIMGNIDYKHSFENLYHEEFVENCKQVFV------------TSKESN-----RTFEILERFAIKDLDLDLDTDSTIAGSGLDSILRINSLPTCKSILLLSGERGCGKSTLIANWVSNFQSKHPGVLMIPYFVGSTCESCDIMSVIHYFVMELQHRANGPRLEMDFLNEDSNVLVFSLLVEVFIAAISLKPCILVLDGIEELIGIY-----------GISGQKAKDFSWLPRSLPPHCKFILSSVSSSLS-CKSLCARPDVKIVEL 495          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Mouse
Match: Ttc41 (tetratricopeptide repeat domain 41 [Source:MGI Symbol;Acc:MGI:2387653])

HSP 1 Score: 67.0106 bits (162), Expect = 1.081e-10
Identity = 98/403 (24.32%), Postives = 170/403 (42.18%), Query Frame = 2
Query:  140 PFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCFDLIYPNPKPM-DILSNPLKDF-------VSINLDSIKQNGSISICLLGENFERLPKLYEDIGYDYPEFL-------------ENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPI---SDDDDGNENEIESKQPSSENDRME--NLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFER-FPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSV--TIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQS-KTKNTDVICIPYYCEASYASSDLQKMLNSLIKRIR 1258
            P+I S+  DF  E + +   IFP +      +  +     DL +   K      SN  + +       + ++LD + +     I LLG+        Y D   DY  FL             E +L IAA +GYPW+    N    S+ E          + ++  FYFR S   +   +++++  E ++ S    +E  +M+   LK  +I +GLP++FY    E      KD   + E+ +P        M       + + L    F EN K++F             T  E+N     R  E+L  F  KD    L    TI      ++  I++      IL+L+G RG GKS+++ NW+ + ++K+  V+ IPY+  ++  S D+  +++  +  ++
Sbjct:   26 PYICST-LDFQEERDFLAKSIFPRLNDICSSRGTY-FKAVDLRWSAVKAHKSFTSNQFRQYSCLQSQHLKLSLDYVNRCFPFFIGLLGQT-------YGDFLPDYTPFLLSQVKDFESLSKGEQNLYIAAKNGYPWVLKTPN---CSLTEFEIIQAVFRKKSQFQFFYFRTSNSLLRTFNEEEEEEEEKLSSAYLLNEQGKMKVGKLKAKIIGKGLPVRFYRDLEELGDMVWKDWSAVVEKLYP----FTTIMGNIDYKHSFENLYHEEFVENCKQVFV------------TSKESN-----RTFEILERFAIKDLDLDLDTDSTIAGSGLDSILRINSLPTCKSILLLSGERGCGKSTLIANWVSNFQSKHPGVLMIPYFVGSTCESCDIMSVIHYFVMELQ 395          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Mouse
Match: Ttc41 (tetratricopeptide repeat domain 41 [Source:MGI Symbol;Acc:MGI:2387653])

HSP 1 Score: 67.0106 bits (162), Expect = 1.081e-10
Identity = 98/403 (24.32%), Postives = 170/403 (42.18%), Query Frame = 2
Query:  140 PFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCFDLIYPNPKPM-DILSNPLKDF-------VSINLDSIKQNGSISICLLGENFERLPKLYEDIGYDYPEFL-------------ENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPI---SDDDDGNENEIESKQPSSENDRME--NLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFER-FPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSV--TIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQS-KTKNTDVICIPYYCEASYASSDLQKMLNSLIKRIR 1258
            P+I S+  DF  E + +   IFP +      +  +     DL +   K      SN  + +       + ++LD + +     I LLG+        Y D   DY  FL             E +L IAA +GYPW+    N    S+ E          + ++  FYFR S   +   +++++  E ++ S    +E  +M+   LK  +I +GLP++FY    E      KD   + E+ +P        M       + + L    F EN K++F             T  E+N     R  E+L  F  KD    L    TI      ++  I++      IL+L+G RG GKS+++ NW+ + ++K+  V+ IPY+  ++  S D+  +++  +  ++
Sbjct:   26 PYICST-LDFQEERDFLAKSIFPRLNDICSSRGTY-FKAVDLRWSAVKAHKSFTSNQFRQYSCLQSQHLKLSLDYVNRCFPFFIGLLGQT-------YGDFLPDYTPFLLSQVKDFESLSKGEQNLYIAAKNGYPWVLKTPN---CSLTEFEIIQAVFRKKSQFQFFYFRTSNSLLRTFNEEEEEEEEKLSSAYLLNEQGKMKVGKLKAKIIGKGLPVRFYRDLEELGDMVWKDWSAVVEKLYP----FTTIMGNIDYKHSFENLYHEEFVENCKQVFV------------TSKESN-----RTFEILERFAIKDLDLDLDTDSTIAGSGLDSILRINSLPTCKSILLLSGERGCGKSTLIANWVSNFQSKHPGVLMIPYFVGSTCESCDIMSVIHYFVMELQ 395          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. UniProt/SwissProt
Match: sp|Q6P3V7|TTC41_RAT (Tetratricopeptide repeat protein 41 OS=Rattus norvegicus OX=10116 GN=Ttc41 PE=2 SV=2)

HSP 1 Score: 77.7962 bits (190), Expect = 1.030e-12
Identity = 97/411 (23.60%), Postives = 158/411 (38.44%), Query Frame = 2
Query:  140 PFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCFDLIYPNPKPMDILSNPL--------KDFVSINLDSIKQNGSISICLLGENFERLPKLYEDIGYDYPEFL-------------ENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIESKQPSSENDR-----MENLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQS-KTKNTDVICIPYYCEASYASSDLQKMLNSLIKRIRLDC-GYNLEQD 1288
            P+I S+  DF  E + +   IFP +  +   +  +     DL +   K     +N             + + LD + +     ICLLG+        Y D   DY  FL             E +L +AA +GYPW+    N    S+ E          + ++  FYFR S   +    +  E E E      + DR     +  LK  +I +GLP++FY    E      KD   + E           M       + + L    F EN K++F                   S    R  E+L  F  KD       T+      ++  I++      IL+L G RG GKS+++ NW+   K+++  V+ +PY+  ++  S D+  +++  I  ++    G  LE D
Sbjct:   26 PYICST-IDFQDERDFLAKTIFPQLNDFCSSRGTY-FKAVDLRWSALKAHKSFTNNQFRQYSCLHSQHLKLCLDYVNRCFPFFICLLGQT-------YGDFLPDYTPFLLSKVKDLESLSKGEQNLYVAAKNGYPWVLKTPN---CSLTEFEIIQAAFRKKSQFQFFYFRTSNSLLRTFSEEEEEEEEKLSSGYQVDRQGKVKVGKLKAKIIGKGLPVRFYRDLDELGDMVLKDWSAVVEEL---YPVTMIMENIDYKHSFENLYHEEFVENCKQVF-----------------VISKESNRTFEMLERFAIKDLELNSDSTVAGAGLDSILRINSLPTCKSILLLCGERGCGKSTLIANWVDDFKSRHPGVLMVPYFVGSTCESCDIMSVMHYFIMELQHRANGPQLEMD 404          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. UniProt/SwissProt
Match: sp|Q6P2S7|TTC41_HUMAN (Putative tetratricopeptide repeat protein 41 OS=Homo sapiens OX=9606 GN=TTC41P PE=5 SV=3)

HSP 1 Score: 77.0258 bits (188), Expect = 1.757e-12
Identity = 103/423 (24.35%), Postives = 169/423 (39.95%), Query Frame = 2
Query:  140 PFIISSGDDFTYELNAIKNEIFPSVK------SYYFPKKHFSVNCFDLIYPNPKPMDIL---SNPLKDFVSINLDSIKQNGSISICLLGENFERLPKLYEDIGYDYPEFLEN------------SLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIESKQPSS------ENDRMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKK---IFSEFNSLYTSLTKWTLNET-----NSNPEARIDELLNDFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQS-KTKNTDVICIPYY----CEASYASSDLQKMLNSLIKRIRLDCGYNLEQD 1288
            P+I S+ +DF  E + + N IFP +         YF  K   ++   L  P   P  +    S      + + LD +       IC+LG+        Y D   DY  F+ +            +L +AA +GYPW+     N   S+ E        L+E ++  FYFR     +   DD  + E   + PSS      E  R+  LK  +I +GLP++FY    E  +   KD   + E+          +       + +R     F E  K+   I  E +  +  L K+ L +      N   ++ +D +   F              R+N       + +Y+   IL+L+   G GKS+++ NW+   K K+  ++ IP++    CE+SY  S +   +  L  R   + G  LE D
Sbjct:   25 PYICSTLNDFQEERDFLANNIFPQLNELCNSWGTYF--KAVDLSWSALKAPKSLPTHLFRQYSCLRSQRLKLCLDYVNSCFPFFICMLGQT-------YGDFLPDYSHFMTSKVTRLSSLSKVENLYVAAKNGYPWVLE---NPSCSLTEFEIIQAAFLNESQFQYFYFRTGTTLLKALDDEKKGE---RLPSSSSTNEEETLRIGKLKAKIISKGLPVRFYSDLHELGELVFKDWSVVIEKLH---PATLMIENIDYKHSFERFYHEEFTEKCKQMCVISKESDRTFEILEKFALKDVELDFNNVAADSSLDSVPRFF--------------RINP------TPTYKS--ILLLSREHGCGKSTLIANWVNYFKKKHPSMLLIPHFVGSTCESSYIMSVIHYFITELQYR---NYGTQLETD 404          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. UniProt/SwissProt
Match: sp|Q692V3|TTC41_MOUSE (Tetratricopeptide repeat protein 41 OS=Mus musculus OX=10090 GN=Ttc41 PE=1 SV=1)

HSP 1 Score: 68.5514 bits (166), Expect = 6.556e-10
Identity = 121/521 (23.22%), Postives = 212/521 (40.69%), Query Frame = 2
Query:  137 FPFIISSGDDFTYELNAIKNEIFP------SVKSYYFPKKHFSVNCFDLIYPNPKPM-DILSNPLKDF-------VSINLDSIKQNGSISICLLGENFERLPKLYEDIGYDYPEFL-------------ENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPI---SDDDDGNENEIESKQPSSENDRME--NLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSV--TIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQS-KTKNTDVICIPYYCEASYASSDLQKMLNSLIKRI-------RLDCGYNLEQDDYETYSLETEMLSLSQKFLGAMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEV 1573
             P+I S+  DF  E + +   IFP      S +  YF          DL +   K      SN  + +       + ++LD + +     I LLG+        Y D   DY  FL             + +L IAA +GYPW+    N    S+ E          + ++  FYFR S   +   +++++  E ++ S    +E  +M+   LK  +I +GLP++FY    E      KD   + E+          M       + + L    F EN K++F             T  E+N     R  E+L  F  KD    L    TI      ++  I++      IL+L+G RG GKS+++ NW+ + ++K+  V+ IPY+  ++  S D+  +++  +  +       RL+  +  E  +   +SL  E+   +      +L+   I   + I              S ++ K   W+P  +P + + I++S +S  S  +    R D+ I+E+
Sbjct:   25 LPYICST-LDFQEERDFLAKSIFPRLNDICSSRGTYF-------KAVDLRWSAVKAHKSFTSNQFRQYSCLQSQHLKLSLDYVNRCFPFFIGLLGQT-------YGDFLPDYTPFLLSQVKDFESLSKGKKNLYIAAKNGYPWVLKTPN---CSLTEFEIIQAVFRKKSQFQFFYFRTSNSLLRTFNEEEEEEEEKLSSAYLLNEQGKMKVGKLKAKIIGKGLPVRFYRDLEELGDMVWKDWSAVVEKL---YPFTTIMGNIDYKHSFENLYHEEFVENCKQVFV------------TSKESN-----RTFEILERFAIKDLDLDLDTDSTIAGSGLDSILRINSLPTCKSILLLSGERGCGKSTLIANWVSNFQSKHPGVLMIPYFVGSTCESCDIMSVIHYFVMELQHRANGPRLEMDFLNEDSNVLVFSLLVEVFIAAISLKPCILVLDGIEELIGIY-----------GISGQKAKDFSWLPRSLPPHCKFILSSVSSSLS-CKSLCARPDVKIVEL 495          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. TrEMBL
Match: A0A1I8JC28 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 104.375 bits (259), Expect = 1.876e-35
Identity = 136/554 (24.55%), Postives = 238/554 (42.96%), Query Frame = 2
Query:  434 EFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIES--KQPSSEND----RMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMD-IFERFPDKI-----SXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARI-DELLNDFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQSKTKNTDV----------------------ICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSLETEMLSLSQKFLG---AMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEVLPGSIDEQNELIKSGIDGLKTWISKHGQVYPSNFPQPIYSWPLIAN-PLIQKILARVYHTLGTTV-KWKSFIEKASECQTLVELVRRVLKFHIYHINW---ELTVKSDKLKKNYIVNKEEEMEERSIQGWVPDCLS 1966
            E+L+ SL+ AA++GY W+ N +    SS+ ++ +     L   K+   Y R +    S      E E E   KQ   E+D    ++E LKQ LIR+GLPIKF+ +  E  +    D  + +  R+ D +     S  D M  DQ+I  + RLQ    N +  +  ++ +            E +    A +  + L+ F R+D S+ ++ T    + +  S    S    +I +L G RG GKS++L +WL++  +   V                      + IPYY  A+ AS D    +  + +R+      N     +E   L  +     Q+ +G   A L    I   +  +    D +G +C     ++K   W+P  +P   RI+ ++ +SD + A +  +R+D+ I                +G + +  + +  GQ    +F +     PL  + PL Q +LA  YH +G T  K  +F+    +  ++ +L   +L+       W    L  KSD+ +K+ +  KEE   +   + WV + L+
Sbjct:  863 EWLKASLKKAAENGYTWLLN-DAYTNSSVNDLQTTLAVFLKACKHCFIYVRSAAHQDSLYRHLGEAERERLLKQFKVESDYAAMKVEELKQRLIRKGLPIKFFTTPDELEQVILADFEEHLGVRYIDSVDLPGMSLFDAMERDQRIEQELRLQGLQINSDFSRCIADIDRFVAD------GEEDDRANASVAHDPLDAFVRRDHSEIMAKT----HLQQHSGARQSATSPRIFLLAGERGCGKSTLLSHWLRNYAETQAVARADAASDGGPAGEAAWLRQQPLVIPYYVGANRASCDAMNFMELVKQRVH----RNFNVRSHEPPFLMLDPAFTYQEVVGSFEAALSMGKILLVIDGLDCFGDSVGCRC----DEVKRLAWLPARLPPGCRIVASTLSSDLTCASLS-RRSDVQIYRF--------GATADTGAEMMANFSADFGQTPGDDFWEAFVESPLAPSCPLAQALLALEYHIVGCTADKRAAFVNAVGDLVSIRQLFLHLLRRWSSEYGWVKLTLMEKSDQTQKS-LFEKEESQIKHEWEDWVSESLA 1387          

HSP 2 Score: 78.1814 bits (191), Expect = 1.876e-35
Identity = 49/145 (33.79%), Postives = 72/145 (49.66%), Query Frame = 1
Query: 1966 LLVLSRNGLPLDIILSCLDKLGYVKDFEVVESDVWSLFHLTREIILKFHNEKFKLTHSICKEIVEHAFLAIASCSSVEARTRECQEYMYIDKRCKFHLLLAYHFWNQRNANLENISECVYHLDRGSDYESMETVLFLPRTLLGLF 2400
            L+ LSR GL L  ILS L +LGY    +V   D W  F  +    L+  + ++K  H    EIVEH F +  + ++VE R +  +       R KFH LL +HF  + +      +E +YH DR S +E +  +L  P   L +F
Sbjct: 1388 LIALSRRGLCLQGILSLLGRLGYSSQAQVALFD-WHRFFNSAAGTLQLVDGRYKFIHMHFAEIVEHIFFSCVAPAAVETRCKPSRLPTASGLRYKFHSLLGHHFLEEGDH-----AEAIYHFDRASQFEKLMEILSDPYVFLDVF 1526          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. TrEMBL
Match: A0A267FI96 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013431g1 PE=4 SV=1)

HSP 1 Score: 104.76 bits (260), Expect = 5.938e-35
Identity = 136/554 (24.55%), Postives = 238/554 (42.96%), Query Frame = 2
Query:  434 EFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIES--KQPSSEND----RMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMD-IFERFPDKI-----SXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARI-DELLNDFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQSKTKNTDV----------------------ICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSLETEMLSLSQKFLG---AMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEVLPGSIDEQNELIKSGIDGLKTWISKHGQVYPSNFPQPIYSWPLIAN-PLIQKILARVYHTLGTTV-KWKSFIEKASECQTLVELVRRVLKFHIYHINW---ELTVKSDKLKKNYIVNKEEEMEERSIQGWVPDCLS 1966
            E+L+ SL+ AA++GY W+ N +    SS+ ++ +     L   K+   Y R +    S      E E E   KQ   E+D    ++E LKQ LIR+GLPIKF+ +  E  +    D  + +  R+ D +     S  D M  DQ+I  + RLQ    N +  +  ++ +            E +    A +  + L+ F R+D S+ ++ T    + +  S    S    +I +L G RG GKS++L +WL++  +   V                      + IPYY  A+ AS D    +  + +R+      N     +E   L  +     Q+ +G   A L    I   +  +    D +G +C     ++K   W+P  +P   RI+ ++ +SD + A +  +R+D+ I                +G + +  + +  GQ    +F +     PL  + PL Q +LA  YH +G T  K  +F+    +  ++ +L   +L+       W    L  KSD+ +K+ +  KEE   +   + WV + L+
Sbjct:  158 EWLKASLKKAAENGYTWLLN-DAYTNSSVNDLQTTLAVFLKACKHCFIYVRSAAHQDSLYRHLGEAERERLLKQFKVESDYAAMKVEELKQRLIRKGLPIKFFTTPDELEQVILADFEEHLGVRYIDSVDLPGMSLFDAMERDQRIEQELRLQGLQINSDFSRCIADIDRFVAD------GEEDDRANASVAHDPLDAFVRRDHSEIMAKT----HLQQHSGARQSATSPRIFLLAGERGCGKSTLLSHWLRNYAETQAVARADAASDGGPAGEAAWLRQQPLVIPYYVGANRASCDAMNFMELVKQRVH----RNFNVRSHEPPFLMLDPAFTYQEVVGSFEAALSMGKILLVIDGLDCFGDSVGCRC----DEVKRLAWLPARLPPGCRIVASTLSSDLTCASLS-RRSDVQIYRF--------GATADTGAEMMANFSADFGQTPGDDFWEAFVESPLAPSCPLAQALLALEYHIVGCTADKRAAFVNAVGDLVSIRQLFLHLLRRWSSEYGWVKLTLMEKSDQTQKS-LFEKEESQIKHEWEDWVSESLA 682          

HSP 2 Score: 75.8702 bits (185), Expect = 5.938e-35
Identity = 49/146 (33.56%), Postives = 72/146 (49.32%), Query Frame = 1
Query: 1966 LLVLSRNGLPLDIILSCLDKLGYVKDFEVVESDVWSLFHLTREIILKFHNEKFKLTHSICKEIVEHAFLAIASCSSVEARTRECQEYMYIDKRCKFHLLLAYHFWNQRNANLENISECVYHLDRGSDYESMETVLFLPRTLLGLFN 2403
            L+ LSR GL L  ILS L +LGY    +V   D W  F  +    L+  + ++K  H    EIVEH F +  + ++VE R +  +       R KFH LL +HF  + +      +E +YH DR S +E +  +L  P   L +F 
Sbjct:  683 LIALSRRGLCLQGILSLLGRLGYSSQAQVALFD-WHRFFNSAAGTLQLVDGRYKFIHMHFAEIVEHIFFSCVAPAAVETRCKPSRLPTASGLRYKFHSLLGHHFLEEGDH-----AEAIYHFDRASQFEKLMEILSDPYVFLDVFG 822          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. TrEMBL
Match: A0A1I8JG25 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 104.375 bits (259), Expect = 7.139e-35
Identity = 135/553 (24.41%), Postives = 238/553 (43.04%), Query Frame = 2
Query:  434 EFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIES--KQPSSEND----RMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMD-IFERFPDKI-----SXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQSKTKNTDV----------------------ICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSLETEMLSLSQKFLG---AMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEVLPGSIDEQNELIKSGIDGLKTWISKHGQVYPSNFPQPIYSWPLIAN-PLIQKILARVYHTLGTTV-KWKSFIEKASECQTLVELVRRVLKFHIYHINW---ELTVKSDKLKKNYIVNKEEEMEERSIQGWVPDCLS 1966
            E+L+ SL+ AA++GY W+ N +    SS+ ++ +     L   K+   Y R +    S      E E E   KQ   E+D    ++E LKQ LIR+GLPIKF+ +  E  +    D  + +  R+ D +     S  D M  DQ+I  + RLQ    N +  +  ++ +            E +    +   + L+ F R+D S+ ++ T    + +  S    S +  +I +L G RG GKS++L +WL++  +   V                      + IPYY  A+ AS D    +  + +R+      N     +E   L  +     Q+ +G   A L    I   +  +    D +G +C     ++K   W+P  +P   RI+ ++ +SD + A +  +R+D+ I                +G + +  + +  GQ    +F +     PL  + PL Q +LA  YH +G T  K  +F+    +  ++ +L   +L+       W    L  KSD+ +K+ +  KEE   +   + WV + L+
Sbjct:  161 EWLKASLKKAAENGYTWLLN-DAYTNSSVNDLQTTLAVFLKACKHCFIYVRSAAHQDSLYRHLGEAERERLLKQFKVESDYAAMKVEELKQRLIRKGLPIKFFTTPDELEQVILADFEEHLGVRYIDSVDLPGMSLFDAMERDQRIEQELRLQGLQINSDFSRCIADIDRFVAD-----GEEDDRANMSVAHDPLDAFVRRDHSEIMAKT----HLQQHSGARQSAKSPRIFLLAGERGCGKSTLLSHWLRNYAETQAVARADAASDGGPAGEAAWLRRQPLVIPYYVGANRASCDAMNFMELVKQRVH----RNFNVRSHEPPFLMLDPAFTYQEVVGSFEAALSMGKILLVIDGLDCFGDSVGCRC----DEVKRLAWLPARLPPGCRIVASTLSSDLTCASLS-RRSDVQIYRF--------GATADTGAEMMANFSADFGQTPGDDFWEAFVESPLAPSCPLAQALLALEYHIVGCTADKRAAFVNAVGDLVSIRQLFLHLLRRWSSEYGWVKLTLMEKSDQTQKS-LFEKEESQIKHEWEDWVSESLA 685          

HSP 2 Score: 76.2554 bits (186), Expect = 7.139e-35
Identity = 49/146 (33.56%), Postives = 72/146 (49.32%), Query Frame = 1
Query: 1966 LLVLSRNGLPLDIILSCLDKLGYVKDFEVVESDVWSLFHLTREIILKFHNEKFKLTHSICKEIVEHAFLAIASCSSVEARTRECQEYMYIDKRCKFHLLLAYHFWNQRNANLENISECVYHLDRGSDYESMETVLFLPRTLLGLFN 2403
            L+ LSR GL L  ILS L +LGY    +V   D W  F  +    L+  + ++K  H    EIVEH F +  + ++VE R +  +       R KFH LL +HF  + +      +E +YH DR S +E +  +L  P   L +F 
Sbjct:  686 LIALSRRGLCLQGILSLLGRLGYSSQAQVALFD-WHRFFNSAAGTLQLVDGRYKFIHMHFAEIVEHIFFSCVAPAAVETRCKPSRLPTASGLRYKFHSLLGHHFLEEGDH-----AEAIYHFDRASQFEKLMEILSDPYVFLDVFG 825          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. TrEMBL
Match: A0A1I8HRS8 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 1.062e-34
Identity = 135/553 (24.41%), Postives = 239/553 (43.22%), Query Frame = 2
Query:  434 EFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIES--KQPSSEND----RMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMD-IFERFPDKI-----SXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQSKTKNTDV----------------------ICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSLETEMLSLSQKFLG---AMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEVLPGSIDEQNELIKSGIDGLKTWISKHGQVYPSNFPQPIYSWPLIAN-PLIQKILARVYHTLGTTV-KWKSFIEKASECQTLVELVRRVLKFHIYHINW---ELTVKSDKLKKNYIVNKEEEMEERSIQGWVPDCLS 1966
            E+L+ SL+ AA++GY W+ N +    SS+ ++ +     L   K+   Y R +    S      E E E   KQ   E+D    ++E LKQ LIR+GLPIKF+ +  E  +    D  + +  R+ D +     S  D M  DQ+I  + RLQ    N +  +  ++ +            E +    +   + L+ F R+D S+ ++ T   L + + +  S +    +I +L G RG GKS++L +WL++  +   V                      + IPYY  A+ AS D    +  + +R+      N     +E   L  +     Q+ +G   A L    I   +  +    D +G +C     ++K   W+P  +P   RI+ ++ +SD + A +  +R+D+ I                +G + +  + +  GQ    +F +     PL  + PL Q +LA  YH +G T  K  +F+    +  ++ +L   +L+       W    L  KSD+ +K+ +  KEE   +   + WV + L+
Sbjct:  161 EWLKASLKKAAENGYTWLLN-DAYTNSSVNDLQTTLAVFLKACKHCFVYVRSAAHQDSLYRHLGEAERERLLKQFKVESDYAAMKVEELKQRLIRKGLPIKFFTTPDELEQVILADFEEHLGVRYIDSVDLPGMSLFDAMERDQRIEQELRLQGLQINSDFSRCIADIDRFVAD-----GEEDDRANMSVAHDPLDAFVRRDHSEIMAKT--HLQQHSGARQSAT--SPRIFLLAGERGCGKSTLLSHWLRNYAETQAVARADAASDGGPAGEAAWLRRQPLVIPYYVGANRASCDAMNFMELVKQRVH----RNFNVRSHEPPFLMLDPAFTYQEVVGSFEAALSMGKILLVIDGLDCFGDSVGCRC----DEVKRLAWLPARLPPGCRIVASTLSSDLTCASLS-RRSDVQIYRF--------GATADTGAEMMANFSADFGQTPGDDFWEAFVESPLAPSCPLAQALLALEYHIVGCTADKRAAFVNAVGDLVSIRQLFLHLLRRWSSEYGWVKLTLMEKSDQTQKS-LFEKEESQIKHEWEDWVSESLA 685          

HSP 2 Score: 76.2554 bits (186), Expect = 1.062e-34
Identity = 49/146 (33.56%), Postives = 72/146 (49.32%), Query Frame = 1
Query: 1966 LLVLSRNGLPLDIILSCLDKLGYVKDFEVVESDVWSLFHLTREIILKFHNEKFKLTHSICKEIVEHAFLAIASCSSVEARTRECQEYMYIDKRCKFHLLLAYHFWNQRNANLENISECVYHLDRGSDYESMETVLFLPRTLLGLFN 2403
            L+ LSR GL L  ILS L +LGY    +V   D W  F  +    L+  + ++K  H    EIVEH F +  + ++VE R +  +       R KFH LL +HF  + +      +E +YH DR S +E +  +L  P   L +F 
Sbjct:  686 LIALSRRGLCLQGILSLLGRLGYSSQAQVALFD-WHRFFNSAAGTLQLVDGRYKFIHMHFAEIVEHIFFSCVAPAAVETRCKPSRLPTASGLRYKFHSLLGHHFLEEGDH-----AEAIYHFDRASQFEKLMEILSDPYVFLDVFG 825          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. TrEMBL
Match: A0A1I8JAW9 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 1.153e-34
Identity = 136/553 (24.59%), Postives = 240/553 (43.40%), Query Frame = 2
Query:  434 EFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIES--KQPSSEND----RMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMD-IFERFPDKI-----SXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQSKTKNTDV----------------------ICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSLETEMLSLSQKFLG---AMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEVLPGSIDEQNELIKSGIDGLKTWISKHGQVYPSNFPQPIYSWPLIAN-PLIQKILARVYHTLGTTV-KWKSFIEKASECQTLVELVRRVLKFHIYHINW---ELTVKSDKLKKNYIVNKEEEMEERSIQGWVPDCLS 1966
            E+L+ SL+ AA++GY W+ N +    SS+ ++ +     L   K+   Y R +    S      E E E   KQ   E+D    ++E LKQ LIR+GLPIKF+ +  E  +    D  + +  R+ D +     S  D M  DQ+I  + RLQ    N +  +  ++ +       +    +  +N     D  L+ F R+D S+ ++ T   L + + +  S +    +I +L G RG GKS++L +WL++  +   V                      + IPYY  A+ AS D    +  + +R+      N     +E   L  +     Q+ +G   A L    I   +  +    D +G +C     ++K   W+P  +P   RI+ ++ +SD + A +  +R+D+ I                +G + +  + +  GQ    +F +     PL  + PL Q +LA  YH +G T  K  +F+    +  ++ +L   +L+       W    L  KSD+ +K+ +  KEE   +   + WV + L+
Sbjct:  161 EWLKASLKKAAENGYTWLLN-DAYTNSSVNDLQTTLAVFLKACKHCFIYVRSAAHQDSLYRHLGEAERERLLKQFKVESDYAAMKVEELKQRLIRKGLPIKFFTTPDELEQVILADFEEHLGVRYIDSVDLPGMSLFDAMERDQRIEQELRLQGLQINSDFSRCIADIDRFVADGEE----DDRANMSVAHDP-LDAFVRRDHSEIMAKT--HLQQHSGARQSAT--SPRIFLLAGERGCGKSTLLSHWLRNYAETQAVARADAASDGGPAGEAAWLRRQPLVIPYYVGANRASCDAMNFMELVKQRVH----RNFNVRSHEPPFLMLDPAFTYQEVVGSFEAALSMGKILLVIDGLDCFGDSVGCRC----DEVKRLAWLPARLPPGCRIVASTLSSDLTCASLS-RRSDVQIYRF--------GATADTGAEMMANFSADFGQTPGDDFWEAFVESPLAPSCPLAQALLALEYHIVGCTADKRAAFVNAVGDLVSIRQLFLHLLRRWSSEYGWVKLTLMEKSDQTQKS-LFEKEESQIKHEWEDWVSESLA 685          

HSP 2 Score: 76.2554 bits (186), Expect = 1.153e-34
Identity = 49/146 (33.56%), Postives = 72/146 (49.32%), Query Frame = 1
Query: 1966 LLVLSRNGLPLDIILSCLDKLGYVKDFEVVESDVWSLFHLTREIILKFHNEKFKLTHSICKEIVEHAFLAIASCSSVEARTRECQEYMYIDKRCKFHLLLAYHFWNQRNANLENISECVYHLDRGSDYESMETVLFLPRTLLGLFN 2403
            L+ LSR GL L  ILS L +LGY    +V   D W  F  +    L+  + ++K  H    EIVEH F +  + ++VE R +  +       R KFH LL +HF  + +      +E +YH DR S +E +  +L  P   L +F 
Sbjct:  686 LIALSRRGLCLQGILSLLGRLGYSSQAQVALFD-WHRFFNSAAGTLQLVDGRYKFIHMHFAEIVEHIFFSCVAPAAVETRCKPSRLPTASGLRYKFHSLLGHHFLEEGDH-----AEAIYHFDRASQFEKLMEILSDPYVFLDVFG 825          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Nematostella
Match: EDO45428 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RT98])

HSP 1 Score: 79.337 bits (194), Expect = 1.488e-14
Identity = 115/514 (22.37%), Postives = 202/514 (39.30%), Query Frame = 2
Query:  140 PFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCFDLIYPNPKPMDILSNPLKDFVSINLDSIKQNGSISICLLGENFE-RLPKLYEDIGYDYPEFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGG---PISDDDDGNENEIESKQPSSEND----RMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNP--EARIDELLNDFYRKDF---------SDKLSV------TIRRLNERTLSHI-------STSYQDN--KILVLTGSRGSGKSSILINWL-QSKTKNTDVICIPYYCEASYASSDLQKMLNSLIKRIRLD-CGYNLEQDDYETYSLETEMLSLSQKFLGAMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEV 1573
            PF+  +  DF  E + + + +FP +      ++  S    DL + + +      + L+    + LD++++     ICLLG+ +    P   E       E+L  + ++A   GY W+   +    SS+ E+         +  Y  FYFR        I   D   E EI       E++    ++  LKQ +I   LP++ + +  E       D   +                                          N+LY+ +  +  + TN+ P  +  + E +++ YR+ F         SD LSV       + R     LSH+       S    D+   IL L G RGSGKS+++  WL Q  T   +V+ +P++     +S+D+   +    + +R    G +L  +D    +  T+   +++ F  A+ L  ++         G  H          Q K   W+P+ IPE  R+IIT+  SD +   +K +R D   IE+
Sbjct:   23 PFVCGTFRDFHAERDFLNDHVFPKLHR-LCQERGTSFLPVDLRWDSKQGQSASDHILR----VCLDNVERCAPYFICLLGDRYGVHRPSESEPPDVATEEWLTKNYELATSHGYEWLKE-DEYRCSSLTELEVVQASFRKKYDYGYFYFRDPEHLKEKIDSADSEEEKEILLSNHKIESEYSAKKLRELKQQVIDTELPVRHFRTLEELGDLVLADWTSV-----------------------------------------INTLYSPIEPFVFSNTNTEPFRQWSLHETVSESYRRTFIRTPRTREISDVLSVHAEVEQGVTRKTSVALSHVMLSTFMTSVPGGDSLPPILTLLGERGSGKSALVSYWLKQFTTARPEVVLVPHHVGCDSSSADVTNFMRRCTRELRTQYLGSDL--NDIIDNNDITDFRRVTEAFHAAIELGPSVIVLDGASEFGKSHD-----LPAYQAKELTWLPKEIPEFCRLIITTIKSDITYRALK-QRKDSYFIEL 481          
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Planmine SMEST
Match: SMESG000012448.1 (SMESG000012448.1)

HSP 1 Score: 1238.4 bits (3203), Expect = 0.000e+0
Identity = 633/644 (98.29%), Postives = 638/644 (99.07%), Query Frame = 1
Query: 1966 LLVLSRNGLPLDIILSCLDKLGYVKDFEVVESDVWSLFHLTREIILKFHNEKFKLTHSICKEIVEHAFLAIASCSSVEARTRECQEYMYIDKRCKFHLLLAYHFWNQRNANLENISECVYHLDRGSDYESMETVLFLPRTLLGLFNLDASQLTNWHGQLTNTHYFQYYKNILSSKGCDFVNHILNLLNTXXXXXXXXXXXXXXXGPDGNDQKLVKLQYQKSVPYQSDFTKRFKIHVDRDEERESWLTLDQAQRNHFMLFLGRICELMDQMALARKIFNYLEDTLDDKVLLCSILWFDISLDSSLQTIFRNEDYILLVXXXXXXXXXXXXXXXWFDGSTENDTIKYIRSMCLILKCSIGAKTINEIYSPSEYHELRILSESFNSVILNCLVKEMNFNSMGETKDVKITQQKILMLSNIIILLETWTGPAHSHMARLFVKLSRLFEHGNSQLRFKAEACCRRALWIWKYMNKNKTNDYNSEENECREILFQFLIKDPCKSSIIEAKNQIYLTFDSRMKYLGCYHPLTVNLVPSIKLVNNLSDRSRYLLKPDSKILLSNSSKRSIPGSSSFTRNQSNLRVNRSVIDTIGKSRSAESNKVNDHRISESYGSSLQFINRYSKSADGFSEDIDWNEIAHSSSTSLMSRFS 3897
            LLVLSRNGLPLDIILSCLDKLGYVKDFEVVESDVWSLFHLTREIILKFHNEKFK THSICKEIVEHAFLAIASCSSVEARTRECQEYMYIDKRCKFHLLLAYHFWNQRNANLENISECVYHLDRGSDYESMET+LFLPRTLLGLFNLDASQLTNWHGQLTNTHYFQYYKNILSSKGCDFVNHILNLLNTFY LEFDAAEAELEDG DGNDQKLVKLQYQKS+PYQSDFTKRFKIHVDRDEE+E+WLTL+QAQRNHFMLFLGRICEL DQMALARKIFNYLEDTLDDKVLLCSILWFDISLDSSLQTIFRNEDYILLVLNKLDDLTADLLKDDWFDGSTENDTIKYIRSMCLILKCSIGAKTINEIYSPSEYHELRILSESFNSVILNCLVKEMNFNSMGETKDVKITQQKILMLSNIIILLETWTGPAHSHMARLFVKLSRLFEHGNSQLRFKAEACCRRALWIWKYMNKNKTNDYNSEENECREILFQFLIKDPCKSSIIEAKNQIYLTFDSRMKYLGCYHPLTVNLVPSIKLVNNLSDRSRYLLKPDSKILLSNSSKRSI GSSSFTRNQSNLRVNRSVIDTIGKSRSA SNKVNDHRISESYGSSLQFINRYSKSADGFSEDIDWNEIAHSSSTSLMSRFS
Sbjct:  620 LLVLSRNGLPLDIILSCLDKLGYVKDFEVVESDVWSLFHLTREIILKFHNEKFKFTHSICKEIVEHAFLAIASCSSVEARTRECQEYMYIDKRCKFHLLLAYHFWNQRNANLENISECVYHLDRGSDYESMETILFLPRTLLGLFNLDASQLTNWHGQLTNTHYFQYYKNILSSKGCDFVNHILNLLNTFYDLEFDAAEAELEDGLDGNDQKLVKLQYQKSIPYQSDFTKRFKIHVDRDEEKETWLTLEQAQRNHFMLFLGRICELTDQMALARKIFNYLEDTLDDKVLLCSILWFDISLDSSLQTIFRNEDYILLVLNKLDDLTADLLKDDWFDGSTENDTIKYIRSMCLILKCSIGAKTINEIYSPSEYHELRILSESFNSVILNCLVKEMNFNSMGETKDVKITQQKILMLSNIIILLETWTGPAHSHMARLFVKLSRLFEHGNSQLRFKAEACCRRALWIWKYMNKNKTNDYNSEENECREILFQFLIKDPCKSSIIEAKNQIYLTFDSRMKYLGCYHPLTVNLVPSIKLVNNLSDRSRYLLKPDSKILLSNSSKRSITGSSSFTRNQSNLRVNRSVIDTIGKSRSAGSNKVNDHRISESYGSSLQFINRYSKSADGFSEDIDWNEIAHSSSTSLMSRFS 1263          

HSP 2 Score: 1195.26 bits (3091), Expect = 0.000e+0
Identity = 615/619 (99.35%), Postives = 618/619 (99.84%), Query Frame = 2
Query:  110 MFHNIDYNNFPFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCFDLIYPNPKPMDILSNPLKDFVSINLDSIKQNGSISICLLGENFERLPKLYEDIGYDYPEFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIESKQPSSENDRMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISXXXXXXXXXXXXAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQSKTKNTDVICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSLETEMLSLSQKFLGAMLLAKNXXXXXXXXXXXXXXXXXKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEVLPGSIDEQNELIKSGIDGLKTWISKHGQVYPSNFPQPIYSWPLIANPLIQKILARVYHTLGTTVKWKSFIEKASECQTLVELVRRVLKFHIYHINWELTVKSDKLKKNYIVNKEEEMEERSIQGWVPDCLS 1966
            MFHNIDYNNFPFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCFDLIYPNPKPMDILSNPLKDFVSINLDSIKQNGSISICLLGENFERLPKLY+DIGYD+PEFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIESKQ SSENDRMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISDQDDMFIDQQIFAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELL+DFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQSKTKNTDVICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSLETEMLSLSQKFLGAMLLAKNIGHRLLIIIDGIDHLGDKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEVLPGSIDEQNELIKSGIDGLKTWISKHGQVYPSNFPQPIYSWPLIANPLIQKILARVYHTLGTTVKWKSFIEKASECQTLVELVRRVLKFHIYHINWELTVKSDKLKKNYIVNKEEEMEERSIQGWVPDCLS
Sbjct:    1 MFHNIDYNNFPFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCFDLIYPNPKPMDILSNPLKDFVSINLDSIKQNGSISICLLGENFERLPKLYKDIGYDFPEFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSEIKYPLFYFRVSGGPISDDDDGNENEIESKQASSENDRMENLKQILIRQGLPIKFYGSASEFNKAFRKDLMDIFERFPDKISDQDDMFIDQQIFAKDRLQMFTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLSDFYRKDFSDKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQSKTKNTDVICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSLETEMLSLSQKFLGAMLLAKNIGHRLLIIIDGIDHLGDKCAFSTKQIKSTDWIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEVLPGSIDEQNELIKSGIDGLKTWISKHGQVYPSNFPQPIYSWPLIANPLIQKILARVYHTLGTTVKWKSFIEKASECQTLVELVRRVLKFHIYHINWELTVKSDKLKKNYIVNKEEEMEERSIQGWVPDCLS 619          

HSP 3 Score: 258.84 bits (660), Expect = 3.037e-69
Identity = 125/127 (98.43%), Postives = 127/127 (100.00%), Query Frame = 2
Query: 5645 VSRIQSAALNNHSSISVNLPSTPVRSQSVIVGNDVPSHIYFGPNSSLRSLCSPNAEDHNRASGSRNGKQVRFINLTKSGKGKFIQTEMAKMIQQKVQEMKLFGDTININQRRSVSTNFSRPYSNTTD 6025
            VSRIQSAALNNHSSISVNLPSTPVRSQSVIVGNDVPSHIYFGPNSSLRSLCSP+AE+HNRASGSRNGKQVRFINLTKSGKGKFIQTEMAKMIQQKVQEMKLFGDTININQRRSVSTNFSRPYSNTTD
Sbjct: 1264 VSRIQSAALNNHSSISVNLPSTPVRSQSVIVGNDVPSHIYFGPNSSLRSLCSPSAENHNRASGSRNGKQVRFINLTKSGKGKFIQTEMAKMIQQKVQEMKLFGDTININQRRSVSTNFSRPYSNTTD 1390          
The following BLAST results are available for this feature:
BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ttc412.417e-1625.11tetratricopeptide repeat domain 41 [Source:ZFIN;Ac... [more]
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ccnol.132.980e-2023.51Putative ortholog of g2/mitotic-specific cyclin B3... [more]
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Ttc411.605e-1123.11tetratricopeptide repeat domain 41 [Source:MGI Sym... [more]
Ttc412.579e-1123.42tetratricopeptide repeat domain 41 [Source:MGI Sym... [more]
Ttc411.081e-1024.32tetratricopeptide repeat domain 41 [Source:MGI Sym... [more]
Ttc411.081e-1024.32tetratricopeptide repeat domain 41 [Source:MGI Sym... [more]
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q6P3V7|TTC41_RAT1.030e-1223.60Tetratricopeptide repeat protein 41 OS=Rattus norv... [more]
sp|Q6P2S7|TTC41_HUMAN1.757e-1224.35Putative tetratricopeptide repeat protein 41 OS=Ho... [more]
sp|Q692V3|TTC41_MOUSE6.556e-1023.22Tetratricopeptide repeat protein 41 OS=Mus musculu... [more]
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8JC281.876e-3524.55Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267FI965.938e-3524.55Uncharacterized protein (Fragment) OS=Macrostomum ... [more]
A0A1I8JG257.139e-3524.41Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8HRS81.062e-3424.41Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8JAW91.153e-3424.59Uncharacterized protein OS=Macrostomum lignano OX=... [more]
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO454281.488e-1422.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TPR repeat-containing protein DDB_G0287407 isoform X2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000012448.13.037e-6998.29SMESG000012448.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008115 ID=SMED30008115|Name=TPR repeat-containing protein DDB_G0287407 isoform X2|organism=Schmidtea mediterranea sexual|type=transcript|length=6122bp
GCCGTGTCTTAGTAAATGATTAAATTTAATTCATGTGATAAATTTGATTA
AAGTTTCTAATAAAAAAATCTCATATATTTTATATAAATTTTGTTACGTC
ACTACACTCATGTTTCATAATATTGATTATAATAACTTTCCATTTATTAT
TTCATCTGGTGACGATTTTACATACGAATTAAACGCAATAAAGAATGAAA
TTTTTCCGAGTGTTAAATCGTATTACTTTCCGAAAAAACATTTTTCCGTA
AATTGTTTTGATCTAATTTATCCGAATCCAAAGCCAATGGATATCCTGTC
AAATCCGTTAAAAGATTTTGTGTCAATTAATTTGGATTCAATTAAGCAAA
ATGGTTCGATTAGCATTTGCTTGCTAGGTGAAAATTTTGAGCGTCTACCA
AAATTATATGAAGATATTGGATATGATTACCCAGAATTTCTGGAGAATTC
CCTGCAAATTGCAGCCGATTCAGGATACCCGTGGATTTATAATATGAATA
ATAACGACCGTTCTAGCATGCTGGAAGTTTTGAGTTTTTATAATGGCTTG
TTGTCAGAAATAAAATACCCATTATTTTATTTTCGGGTTTCGGGAGGTCC
CATTTCTGATGACGATGATGGTAATGAAAATGAAATTGAAAGTAAACAAC
CCAGTAGTGAAAATGACAGAATGGAAAACTTAAAACAAATTTTAATCAGA
CAAGGATTGCCAATAAAATTTTACGGATCTGCCTCGGAATTCAACAAAGC
TTTCAGAAAAGATCTTATGGATATATTTGAAAGATTTCCAGATAAAATAT
CTGATCAAGATGACATGTTCATAGACCAGCAAATTTTTGCAAAAGATCGC
CTACAAATGTTTACTTTTAACGAAAATATTAAGAAAATATTCTCCGAGTT
CAATTCACTTTACACTAGTTTAACAAAATGGACACTAAATGAAACTAATT
CTAATCCTGAAGCCAGGATAGACGAGTTACTTAACGACTTTTATCGAAAA
GATTTCAGTGATAAATTGTCAGTCACAATTAGACGTTTAAATGAAAGGAC
ATTATCTCACATTTCCACCAGTTATCAAGATAATAAAATCTTAGTACTAA
CCGGATCACGCGGATCAGGAAAATCGAGTATTCTCATTAATTGGCTTCAA
TCTAAAACCAAAAACACAGACGTCATTTGTATTCCTTACTACTGTGAAGC
CTCGTATGCGAGTTCCGATTTGCAAAAAATGCTAAATAGTCTAATTAAGC
GAATCAGACTGGATTGCGGGTACAATTTAGAACAAGATGATTATGAAACA
TATTCTTTGGAGACAGAAATGTTATCTTTGAGTCAAAAATTTCTGGGTGC
AATGCTTCTTGCTAAAAATATTGGGCACCGGTTATTGATCATTATAGATG
GCATAGATCACCTTGGAGACAAATGTGCATTTTCCACAAAGCAGATAAAA
TCGACGGATTGGATTCCGGAAGTGATACCGGAAAATGTGAGAATAATAAT
CACATCTACTGCATCGGATTCGTCTCTTGCTCAAATAAAATTCAAGCGTA
CAGATATAGCCATAATAGAAGTATTACCAGGCTCCATAGACGAGCAAAAC
GAGCTCATAAAATCTGGAATTGACGGCTTGAAAACATGGATTTCTAAACA
TGGTCAGGTGTATCCGTCAAATTTCCCCCAGCCAATATACAGTTGGCCTT
TAATCGCAAATCCGCTGATACAGAAAATATTGGCTCGAGTTTATCACACT
CTCGGAACAACAGTAAAATGGAAGTCATTTATCGAAAAGGCCTCAGAATG
CCAAACTCTGGTTGAATTGGTTAGGCGGGTGTTGAAATTCCATATTTACC
ATATAAACTGGGAACTGACAGTAAAATCTGACAAGTTGAAGAAAAACTAT
ATAGTCAACAAGGAAGAAGAAATGGAAGAAAGATCAATTCAAGGCTGGGT
TCCTGATTGCCTGAGTTGTTGGTACTTTCCAGAAACGGACTTCCTCTTGA
TATAATTTTGTCTTGTCTCGATAAATTGGGTTATGTCAAGGATTTCGAAG
TTGTTGAATCAGATGTTTGGAGCCTTTTTCACTTGACTAGGGAAATTATT
TTAAAGTTTCATAATGAAAAGTTTAAATTAACCCATTCGATTTGCAAGGA
AATCGTCGAGCATGCTTTTTTGGCTATAGCAAGTTGTAGTTCCGTGGAAG
CCAGGACTCGCGAGTGCCAGGAATACATGTATATTGACAAAAGGTGTAAG
TTTCATTTACTTTTGGCCTATCATTTCTGGAATCAAAGAAACGCAAACTT
AGAAAACATTTCAGAATGTGTTTATCATTTGGACCGAGGTTCTGATTATG
AGTCGATGGAAACAGTTTTATTTCTTCCTCGCACCCTCCTAGGACTTTTT
AATCTGGACGCTTCTCAGCTGACAAATTGGCACGGACAACTTACTAATAC
TCATTATTTCCAATATTACAAAAACATATTATCATCAAAAGGATGTGATT
TCGTAAATCACATTCTGAATCTTTTGAATACATTTTACTATCTAGAATTC
GACGCAGCTGAGGCTGAATTGGAGGATGGACCTGATGGAAATGATCAGAA
ATTAGTTAAGCTTCAATATCAAAAATCTGTTCCTTATCAATCGGATTTTA
CCAAAAGATTCAAAATCCATGTTGATCGTGACGAAGAAAGGGAATCCTGG
CTGACGTTGGATCAAGCACAGAGAAATCATTTCATGTTATTCCTTGGCAG
AATCTGTGAATTAATGGACCAAATGGCTTTAGCTCGTAAAATTTTCAATT
ATTTAGAAGATACTTTGGACGATAAGGTGTTGCTGTGCAGCATTCTTTGG
TTTGATATATCATTGGATAGTTCACTTCAAACAATATTCCGGAATGAAGA
CTATATTCTATTGGTTCTAAATAAATTGGATGACTTGACAGCGGATTTAC
TGAAAGATGATTGGTTTGACGGTTCGACTGAAAATGATACGATCAAGTAT
ATACGATCCATGTGTTTGATACTGAAATGCTCAATCGGTGCCAAAACAAT
AAATGAAATCTACTCCCCTTCGGAATATCATGAATTGAGGATTCTGAGCG
AATCATTTAATTCTGTGATTTTGAATTGCCTAGTTAAGGAGATGAATTTC
AATTCTATGGGAGAAACTAAAGATGTGAAAATAACACAACAGAAAATATT
AATGTTGTCAAACATTATCATATTATTGGAAACATGGACTGGGCCTGCGC
ATTCTCACATGGCAAGATTATTCGTTAAATTATCCAGATTATTCGAGCAC
GGAAACAGTCAATTGAGATTTAAAGCAGAAGCATGCTGTAGAAGAGCTTT
GTGGATATGGAAATATATGAATAAAAATAAGACCAATGATTACAATAGTG
AGGAAAACGAATGTCGTGAAATTCTTTTCCAATTTCTTATAAAAGACCCC
TGCAAATCCTCGATAATTGAGGCTAAGAATCAAATCTATTTAACTTTTGA
CAGTCGTATGAAATATCTCGGATGCTATCATCCATTGACGGTTAATCTTG
TTCCCTCAATTAAATTAGTGAATAATTTGTCAGATCGGTCTAGATACTTA
TTAAAACCTGATAGCAAAATCCTATTGTCCAATTCATCTAAAAGGTCTAT
TCCCGGCTCATCGTCTTTCACAAGAAACCAATCAAACCTCAGGGTTAATA
GATCAGTGATTGATACTATTGGCAAAAGTCGAAGTGCTGAATCAAATAAG
GTCAATGATCACAGAATCAGTGAATCCTATGGCTCTAGTTTGCAATTTAT
AAATCGATATTCTAAGAGTGCAGATGGATTTAGTGAAGATATTGATTGGA
ATGAGATTGCCCACAGTAGCTCTACGTCGTTGATGAGTCGGTTTTCAGGT
ACAATAAGTTTGTTTTAAATGAAAGCATTATCATTCATCGCTACATAATT
GGTTAGTGTATATTCCAATTAATAAGTTTCAGCAGGATCGTTTCTCTGCG
TGGACTATGTTGGTTATGTGGACTGTCAAATTGCAGGAAAATAAAAACAT
TGTTGAGCTGAGATTCACATGTGTGAACTCGAGTGGCGAGGCAACTGGCA
AATTCCAGGTGGGCCGTTCTAAAAAAAGTCAGATGAAAGGCCGCTGAATT
CAAAGAAACATATAAAATTATAAAATGTTTTTTAAAATAATTATTGTCAA
TTATCTAATATTTATTTACTCTACTTTCCAACATTTAATAATAACAAGCT
TATTTCACTATTTTGTGCGCTGTTAATCTTTTGTTATCCTAAAAACGCCG
CTTTAAAATCGCCTTTCAGGGTCGGTCAAATCGGCCAGTCTGCTACCAAT
TCAGTAAATTACAGAAATATTAATTTAGCTCTTAAAATATGAAAGCCATG
AAGAATTCGTTGAATTGACTGAGGCTTTATAGAACCGATTCTAACTTTTC
TCAGTCAGTGTCTCATTTTGGAAACAAGTCGATATTTTTAATATTTGAAA
GTGTATTCAAAGTTCATCTTCAAACGCGCATTTTTATAATTTTTAATTTC
AAATAAATTTTTCCTAATCTTTGACCTTTACACTCTTTAATAAGTCACAC
GTTTACGATTTTGACACCTTAAATATTATGATGAAAAACAAATTTTTCTG
GTAGATAGCACCAGGAACGAGAAAAACTCACGTGTAATATGGCGTGCAAC
ATTTATTTTGCAATTTACTCTATACTAGTATTTTGTAATGACAATGATTT
AGTAATGATTTGGCTAATAGATTTCATAAAATTTTATTCTTTATAGTTGA
TAAAATGACTGAAGAACAAATTAGATAAACTTTGCTTCTAGAGCTATCCA
AAACCTTTTTATTATTTCAATTTTTTCATTGTTTTTTATATTTTCTAATG
AAATGATAATTACTATGATTTATGATTTTTAAAATATATTCTGAAAATAT
AAACATTTTTAAGATTTTGAAGTAAATGGTAATAGTAAAAAGGAAGAGGT
ACAATAATTACCATAAACATGGACTGTGTTAATTGTGTAAATGAAAGTTA
GGGATGTGTTTGAATTATGCTTCTACTTGCATCACAAATGATGATGAAAA
TGTCTTGGATTTTTATGTTCTAGGAGTTAGAATGTATGGTGCGAGGCGAC
AAGATTCATATTTTTAGCCACTCCCTTACTCTGATAACCGTTATTTGTCG
AGTATAGTAAAATTCATCTGATGTATTATAGCAACTACTAAAATGAAGAA
GAAACGATGCAGACGCTTTAGGTCGATTTTATAAGATTGTTGTTAACAAA
ATGACAATAAGTACAGCATATTGGCATCTTTCCTCCCCTTTTTTACACCT
ACTTGCTATGCTTTTGCAATGAGTTATACTGATAAAACCAAATAATGATA
TATTTCATTCTTAAAATATCGTACTCCAAACGGTTCACGGATATGGTTGC
TTATGACGCCTCATTGCCTGTAGCTAACCCGTCGAACTATTGTCACGTCT
TGTACTATTAATTTGTTTGGAATGTGTTCTGATAAATTTATGCTATTATA
AATTTTGCTCAATTTCTTAATCAACATTTACATAGAGGATTTTAATTAAA
AAAGGAATTTTATATTTGTTGAATGATGCACTTCTTCTTCTTTAGTATCT
CGAATACAAAGCGCTGCATTGAATAATCATTCGAGTATCTCTGTCAATTT
GCCAAGTACTCCGGTTAGATCTCAGTCTGTCATAGTGGGAAATGATGTTC
CTAGTCACATATATTTTGGACCAAATTCATCATTGAGAAGTCTGTGCAGT
CCTAATGCTGAAGACCACAATAGGGCCAGCGGTTCCAGGAACGGCAAACA
AGTTCGATTTATCAATTTAACAAAGTCGGGAAAAGGTAAATTTATCCAAA
CCGAAATGGCAAAAATGATTCAACAAAAAGTTCAAGAAATGAAATTATTT
GGAGATACGATAAACATAAACCAAAGAAGATCAGTTTCCACTAATTTTTC
TAGACCATATTCTAATACCACTGATCTAATTTTTTGACTTTGATTATTAT
TATTATATATATTAAGTCTAATTTCTGTGATTATCACTATGAAATTTTAT
TAATTAATTTATTTATTTTCGG
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protein sequence of SMED30008115-orf-1

>SMED30008115-orf-1 ID=SMED30008115-orf-1|Name=SMED30008115-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=632bp
MFHNIDYNNFPFIISSGDDFTYELNAIKNEIFPSVKSYYFPKKHFSVNCF
DLIYPNPKPMDILSNPLKDFVSINLDSIKQNGSISICLLGENFERLPKLY
EDIGYDYPEFLENSLQIAADSGYPWIYNMNNNDRSSMLEVLSFYNGLLSE
IKYPLFYFRVSGGPISDDDDGNENEIESKQPSSENDRMENLKQILIRQGL
PIKFYGSASEFNKAFRKDLMDIFERFPDKISDQDDMFIDQQIFAKDRLQM
FTFNENIKKIFSEFNSLYTSLTKWTLNETNSNPEARIDELLNDFYRKDFS
DKLSVTIRRLNERTLSHISTSYQDNKILVLTGSRGSGKSSILINWLQSKT
KNTDVICIPYYCEASYASSDLQKMLNSLIKRIRLDCGYNLEQDDYETYSL
ETEMLSLSQKFLGAMLLAKNIGHRLLIIIDGIDHLGDKCAFSTKQIKSTD
WIPEVIPENVRIIITSTASDSSLAQIKFKRTDIAIIEVLPGSIDEQNELI
KSGIDGLKTWISKHGQVYPSNFPQPIYSWPLIANPLIQKILARVYHTLGT
TVKWKSFIEKASECQTLVELVRRVLKFHIYHINWELTVKSDKLKKNYIVN
KEEEMEERSIQGWVPDCLSCWYFPETDFLLI*
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protein sequence of SMED30008115-orf-2

>SMED30008115-orf-2 ID=SMED30008115-orf-2|Name=SMED30008115-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=564bp
MYIDKRCKFHLLLAYHFWNQRNANLENISECVYHLDRGSDYESMETVLFL
PRTLLGLFNLDASQLTNWHGQLTNTHYFQYYKNILSSKGCDFVNHILNLL
NTFYYLEFDAAEAELEDGPDGNDQKLVKLQYQKSVPYQSDFTKRFKIHVD
RDEERESWLTLDQAQRNHFMLFLGRICELMDQMALARKIFNYLEDTLDDK
VLLCSILWFDISLDSSLQTIFRNEDYILLVLNKLDDLTADLLKDDWFDGS
TENDTIKYIRSMCLILKCSIGAKTINEIYSPSEYHELRILSESFNSVILN
CLVKEMNFNSMGETKDVKITQQKILMLSNIIILLETWTGPAHSHMARLFV
KLSRLFEHGNSQLRFKAEACCRRALWIWKYMNKNKTNDYNSEENECREIL
FQFLIKDPCKSSIIEAKNQIYLTFDSRMKYLGCYHPLTVNLVPSIKLVNN
LSDRSRYLLKPDSKILLSNSSKRSIPGSSSFTRNQSNLRVNRSVIDTIGK
SRSAESNKVNDHRISESYGSSLQFINRYSKSADGFSEDIDWNEIAHSSST
SLMSRFSGTISLF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0003674molecular_function
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR007111NACHT_NTPase
IPR027417P-loop_NTPase
Vocabulary: cellular component
TermDefinition
GO:0005575cellular_component
GO:0005737cytoplasm
Vocabulary: biological process
TermDefinition
GO:0008150biological_process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 178..198
NoneNo IPR availableGENE3DG3DSA:3.40.50.300coord: 300..479
e-value: 7.5E-9
score: 37.3
NoneNo IPR availablePANTHERPTHR19871:SF11TETRATRICOPEPTIDE REPEAT PROTEIN 41-RELATEDcoord: 11..628
NoneNo IPR availablePANTHERPTHR19871BETA TRANSDUCIN-RELATED PROTEINcoord: 11..628
IPR007111NACHT nucleoside triphosphatasePFAMPF05729NACHTcoord: 327..486
e-value: 2.3E-6
score: 27.6
IPR027417P-loop containing nucleoside triphosphate hydrolaseSUPERFAMILYSSF52540P-loop containing nucleoside triphosphate hydrolasescoord: 307..534