Mitogen-activated protein kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30008112 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of Mitogen-activated protein kinase vs. Ensembl Human
Match: MAPK15 (mitogen-activated protein kinase 15 [Source:HGNC Symbol;Acc:HGNC:24667]) HSP 1 Score: 405.986 bits (1042), Expect = 1.877e-134 Identity = 183/362 (50.55%), Postives = 258/362 (71.27%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDP---TLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQ 1112
M V+ I++RY ++ ++G GAYGIVWKA+D+++GE VA+KKIFDAF+++TDAQRTFREI LQ+F HPNII+L++V +A+NDRDIYLVFE MD+DL+ VI++G LL+ VH I YQ+L+A +++HSG+V+HRD KPSNVLLD+NCTVKLCDFGL RS LGD P +TEYVATRWYRAPE+LL S +YT VD+WS+GCIL E++ G+ LF G+S+L+Q+E I+ +P PSEED+ ++ S S+L+Q+ +P + + + P + A DL++ LL F P KR + QAL+H Y+++FH P E + ++ P ++ QLS+ EYRS++Y MI +
Sbjct: 1 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARS-----------------LGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
BLAST of Mitogen-activated protein kinase vs. Ensembl Human
Match: MAPK15 (mitogen-activated protein kinase 15 [Source:HGNC Symbol;Acc:HGNC:24667]) HSP 1 Score: 405.986 bits (1042), Expect = 1.877e-134 Identity = 183/362 (50.55%), Postives = 258/362 (71.27%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDP---TLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQ 1112
M V+ I++RY ++ ++G GAYGIVWKA+D+++GE VA+KKIFDAF+++TDAQRTFREI LQ+F HPNII+L++V +A+NDRDIYLVFE MD+DL+ VI++G LL+ VH I YQ+L+A +++HSG+V+HRD KPSNVLLD+NCTVKLCDFGL RS LGD P +TEYVATRWYRAPE+LL S +YT VD+WS+GCIL E++ G+ LF G+S+L+Q+E I+ +P PSEED+ ++ S S+L+Q+ +P + + + P + A DL++ LL F P KR + QAL+H Y+++FH P E + ++ P ++ QLS+ EYRS++Y MI +
Sbjct: 1 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARS-----------------LGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
BLAST of Mitogen-activated protein kinase vs. Ensembl Human
Match: MAPK15 (mitogen-activated protein kinase 15 [Source:HGNC Symbol;Acc:HGNC:24667]) HSP 1 Score: 323.939 bits (829), Expect = 1.151e-106 Identity = 149/266 (56.02%), Postives = 202/266 (75.94%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRS 833
M V+ I++RY ++ ++G GAYGIVWKA+D+++GE VA+KKIFDAF+++TDAQRTFREI LQ+F HPNII+L++V +A+NDRDIYLVFE MD+DL+ VI++G LL+ VH I YQ+L+A +++HSG+V+HRD KPSNVLLD+NCTVKLCDFGL RSL + P+ + D +TEYVATRWYRAPE+LL S +YT VD+WS+GCIL E++ G+ LF G+S+L+Q+E I+ +P PSEE ++ CRS
Sbjct: 1 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDL----PEGPE----------DQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEGAQTA----CRS 248
BLAST of Mitogen-activated protein kinase vs. Ensembl Human
Match: MAPK15 (mitogen-activated protein kinase 15 [Source:HGNC Symbol;Acc:HGNC:24667]) HSP 1 Score: 320.472 bits (820), Expect = 6.825e-105 Identity = 151/288 (52.43%), Postives = 208/288 (72.22%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELM-----------------DSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQI 848
M V+ I++RY ++ ++G GAYGIVWKA+D+++GE VA+KKIFDAF+++TDAQRTFREI LQ+F HPNII+L++V +A+NDRDIYLVFE M D+DL+ VI++G LL+ VH I YQ+L+A +++HSG+V+HRD KPSNVLLD+NCTVKLCDFGL RSL + P+ + D +TEYVATRWYRAPE+LL S +YT VD+WS+GCIL E++ G+ LF G+S+L+Q+E I+ +P PSEED+ ++ S S+L+Q+
Sbjct: 1 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMGCPPSPPPPTAVRTLSADTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDL----PEGPE----------DQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQL 274
BLAST of Mitogen-activated protein kinase vs. Ensembl Human
Match: MAPK15 (mitogen-activated protein kinase 15 [Source:HGNC Symbol;Acc:HGNC:24667]) HSP 1 Score: 320.087 bits (819), Expect = 8.727e-105 Identity = 151/288 (52.43%), Postives = 208/288 (72.22%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELM-----------------DSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQI 848
M V+ I++RY ++ ++G GAYGIVWKA+D+++GE VA+KKIFDAF+++TDAQRTFREI LQ+F HPNII+L++V +A+NDRDIYLVFE M D+DL+ VI++G LL+ VH I YQ+L+A +++HSG+V+HRD KPSNVLLD+NCTVKLCDFGL RSL + P+ + D +TEYVATRWYRAPE+LL S +YT VD+WS+GCIL E++ G+ LF G+S+L+Q+E I+ +P PSEED+ ++ S S+L+Q+
Sbjct: 1 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMGCPPSPPPPTAVRTLSADTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDL----PEGPE----------DQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQL 274
BLAST of Mitogen-activated protein kinase vs. Ensembl Celegans
Match: mapk-15 (Mitogen-activated protein kinase 15 [Source:UniProtKB/Swiss-Prot;Acc:Q11179]) HSP 1 Score: 444.121 bits (1141), Expect = 9.575e-151 Identity = 207/380 (54.47%), Postives = 285/380 (75.00%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAE-KEARTQARRPNEEIKS 1172
MT++V+++I +++D++ R+G GAYGIVWKA DK+S E VALKKIFDAF+N TD+QRTFRE+ FLQ+F HPN+I L N+ +ADNDRDIYL FE M++DLHNVIK+G++LK VHK+YI+ Q+ +A++++HSGNV+HRDLKPSNVLLD++C VKL DFGL RSL +E +P+ K P LTEYVATRWYR+PEILL + +YTK VD+WS+GCILAE+++G+ALF GSS++NQIE+I++ + +PS D+ SI S Y S+L ++ +P K + I A D+V+ LL F P+KR TVEQ L H Y+ +FH+P E ++++E+ PP+ D QLSID+YR +LY+MI +KKA K + + RP E KS
Sbjct: 1 MTDDVDTHIHEKFDLQKRLGKGAYGIVWKAYDKRSRETVALKKIFDAFRNPTDSQRTFREVMFLQEFGKHPNVIKLYNIFRADNDRDIYLAFEFMEADLHNVIKKGSILKDVHKQYIMCQLFRAIRFLHSGNVLHRDLKPSNVLLDADCRVKLADFGLARSLSSLED-YPEGQKM----------PDLTEYVATRWYRSPEILLAAKRYTKGVDMWSLGCILAEMLIGRALFPGSSTINQIERIMNTIAKPSRADIASIGSHYAASVLEKMPQRPRKPLDLII-TQSQTAAIDMVQRLLIFAPQKRLTVEQCLVHPYVVQFHNPSEEPVLNYEVYPPLPDHIQLSIDDYRDRLYEMIDEKKASFKRIQHEKIRPYGEDKS 368
BLAST of Mitogen-activated protein kinase vs. Ensembl Celegans
Match: mpk-1 (Mitogen-activated protein kinase mpk-1 [Source:UniProtKB/Swiss-Prot;Acc:P39745]) HSP 1 Score: 258.84 bits (660), Expect = 2.283e-79 Identity = 147/364 (40.38%), Postives = 215/364 (59.07%), Query Frame = 3
Query: 60 IIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRK--ADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQA 1145
+ RY + IG GAYG+V A+D + + VA+KKI F+++T QRT REI L F I +R D+ +DIY+V LM++DL+ ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R + +TD G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + LF G L+Q+ I++ + PS D++ I ++ RS L + +KP + + ++P D A DL+ +L FNP R +EQAL H Y+E+++DP E + + P E + D + KL ++I ++ R +A
Sbjct: 92 VAPRYVNLSYIGEGAYGMVASALDTITRDRVAIKKI-SPFEHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKL-SNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------TDPQTDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPG-ADPRALDLLDKMLTFNPHNRIDIEQALAHPYLEQYYDPGDEPVCEE----PFTLEMEFD-DLPKEKLKELIWEEAEAHHRRMEA 431
BLAST of Mitogen-activated protein kinase vs. Ensembl Celegans
Match: mpk-1 (Mitogen-activated protein kinase mpk-1 [Source:UniProtKB/Swiss-Prot;Acc:P39745]) HSP 1 Score: 256.144 bits (653), Expect = 3.044e-79 Identity = 147/364 (40.38%), Postives = 215/364 (59.07%), Query Frame = 3
Query: 60 IIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRK--ADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQA 1145
+ RY + IG GAYG+V A+D + + VA+KKI F+++T QRT REI L F I +R D+ +DIY+V LM++DL+ ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R + +TD G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + LF G L+Q+ I++ + PS D++ I ++ RS L + +KP + + ++P D A DL+ +L FNP R +EQAL H Y+E+++DP E + + P E + D + KL ++I ++ R +A
Sbjct: 24 VAPRYVNLSYIGEGAYGMVASALDTITRDRVAIKKI-SPFEHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKL-SNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------TDPQTDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPG-ADPRALDLLDKMLTFNPHNRIDIEQALAHPYLEQYYDPGDEPVCEE----PFTLEMEFD-DLPKEKLKELIWEEAEAHHRRMEA 363
BLAST of Mitogen-activated protein kinase vs. Ensembl Celegans
Match: mpk-2 (Mitogen-activated protein kinase [Source:UniProtKB/TrEMBL;Acc:Q6ABN8]) HSP 1 Score: 247.284 bits (630), Expect = 3.213e-75 Identity = 130/337 (38.58%), Postives = 202/337 (59.94%), Query Frame = 3
Query: 72 YDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKAD--NDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSID 1076
Y + +G GAYG+V KA+D ++ + VA+KKI AF T A+R+ RE+ L++ H NII ++++ A+ + +DIYLV +LM++DLH ++ L H +Y YQ+L+ +KY+HS +IHRDLKPSN+LL+ +C +++ DFG+ R+ + A+ D D N +T+YV+TRWYRAPEIL +Y VDLWS GCI AE++L + LF G S++QI+ IV L P EE + I S+ R + K F+ IFP + A ++V LLQ +P KR++ +Q L+H ++ ++H+ + E + PP Q+ +D
Sbjct: 57 YLAEENVGAGAYGVVCKAMDTRNKKQVAIKKIPRAFTAHTLAKRSLREVRILRELL-HENIIAVLDMFTAEGAHGKDIYLVMDLMETDLHQILHSRQTLMEQHFQYFFYQLLRGLKYLHSAGIIHRDLKPSNLLLNGDCLLRIADFGMARA-------YASASTVRD---DANVGGHMTQYVSTRWYRAPEILFSMVEYDTKVDLWSAGCIFAEMLLRRQLFPGKDSVSQIKMIVYYLGSPEEEVINRITSDLVRDSIEACGRKTPLPFSAIFPKASPE-ARNMVSYLLQISPWKRYSADQILQHPFMAQYHNDQYE-----PLCPP---RVQVDVD 373
BLAST of Mitogen-activated protein kinase vs. Ensembl Celegans
Match: F09C12.2 (Mitogen-activated protein kinase [Source:UniProtKB/TrEMBL;Acc:Q19243]) HSP 1 Score: 242.662 bits (618), Expect = 1.343e-73 Identity = 127/313 (40.58%), Postives = 196/313 (62.62%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNII--TLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFH 1001
+Y + +G GA+G+V +AID K + VA+KKI FKN++ A+ REI ++ S H NII T + +R++ + +DIY+V +LM++DL +V+K L H +Y YQILK +KY+HS +IHRDLKP+N+LL+ +C++K+ DFG++RS ++ P + GD L++YV+T WYRAPEILL +Y VD+WS GCILAE++L + +FTG+ S +QI+ ++ L P E+ + IKS R ++ K F +FP N A ++V +LQ +P KRF+ EQ LE +++ +H
Sbjct: 43 QYLAQENLGAGAFGVVCRAIDSKLNKQVAIKKITRVFKNQSTAKCALREIRITRELS-HENIINSTDVLMRESGSGQDIYIVMDLMETDLLSVLKSNQTLNEKHFQYFFYQILKGLKYLHSAGIIHRDLKPANLLLNEDCSLKIADFGMSRSGPSTKTT-PNTSPNAHISGD------LSQYVSTLWYRAPEILLSMGEYDTQVDIWSAGCILAEMLLLRPIFTGTDSYSQIQLLIEYLGTPDEQVIRRIKSPSIRDYISSFGPKTPLPFTAMFP-NASIEARNIVSKMLQISPWKRFSAEQLLEEPFVKHWH 346
BLAST of Mitogen-activated protein kinase vs. Ensembl Fly
Match: Erk7 (gene:FBgn0052703 transcript:FBtr0302966) HSP 1 Score: 367.851 bits (943), Expect = 3.161e-121 Identity = 170/354 (48.02%), Postives = 245/354 (69.21%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMI 1106
E++ + +D++ R+G GAYGIVWKA D+++ VALKK+FDAF++ETDAQRT+RE+ FL+ F HPNI+ L+++ KA N+ D YLVFE M+SDLHNVIKRGN+LK VHK +++YQ++ A+K+IHSGNVIHRDLKPSN+L+DS C +K+ DFGL R+L S + E DG+ LT+YVATRWYRAPEIL+ S YTK +D+W +GCIL E++ K LF G+S++NQIEKIV++LP ++ D+ SI + +L++ I + + + N LVK LL NP R T ++A+ H Y+ +F E+ + ++VPP+ D + +D+YR+ LY++I
Sbjct: 16 ELDQTVESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTL---SSRRIYDDLEQDGM--------LTDYVATRWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVVPPLKDHVRYDVDQYRNSLYELI 358
BLAST of Mitogen-activated protein kinase vs. Ensembl Fly
Match: Erk7 (gene:FBgn0052703 transcript:FBtr0071329) HSP 1 Score: 368.237 bits (944), Expect = 6.806e-116 Identity = 170/354 (48.02%), Postives = 245/354 (69.21%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMI 1106
E++ + +D++ R+G GAYGIVWKA D+++ VALKK+FDAF++ETDAQRT+RE+ FL+ F HPNI+ L+++ KA N+ D YLVFE M+SDLHNVIKRGN+LK VHK +++YQ++ A+K+IHSGNVIHRDLKPSN+L+DS C +K+ DFGL R+L S + E DG+ LT+YVATRWYRAPEIL+ S YTK +D+W +GCIL E++ K LF G+S++NQIEKIV++LP ++ D+ SI + +L++ I + + + N LVK LL NP R T ++A+ H Y+ +F E+ + ++VPP+ D + +D+YR+ LY++I
Sbjct: 16 ELDQTVESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTL---SSRRIYDDLEQDGM--------LTDYVATRWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVVPPLKDHVRYDVDQYRNSLYELI 358
BLAST of Mitogen-activated protein kinase vs. Ensembl Fly
Match: Erk7 (gene:FBgn0052703 transcript:FBtr0302965) HSP 1 Score: 368.237 bits (944), Expect = 6.806e-116 Identity = 170/354 (48.02%), Postives = 245/354 (69.21%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMI 1106
E++ + +D++ R+G GAYGIVWKA D+++ VALKK+FDAF++ETDAQRT+RE+ FL+ F HPNI+ L+++ KA N+ D YLVFE M+SDLHNVIKRGN+LK VHK +++YQ++ A+K+IHSGNVIHRDLKPSN+L+DS C +K+ DFGL R+L S + E DG+ LT+YVATRWYRAPEIL+ S YTK +D+W +GCIL E++ K LF G+S++NQIEKIV++LP ++ D+ SI + +L++ I + + + N LVK LL NP R T ++A+ H Y+ +F E+ + ++VPP+ D + +D+YR+ LY++I
Sbjct: 16 ELDQTVESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTL---SSRRIYDDLEQDGM--------LTDYVATRWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVVPPLKDHVRYDVDQYRNSLYELI 358
BLAST of Mitogen-activated protein kinase vs. Ensembl Fly
Match: rl (gene:FBgn0003256 transcript:FBtr0113703) HSP 1 Score: 269.24 bits (687), Expect = 3.892e-84 Identity = 146/316 (46.20%), Postives = 199/316 (62.97%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITL---INVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY IG GAYG+V A D + + VA+KKI F+++T QRT REI L F H NII + + V D RD+Y+V LM++DL+ ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL+ C +K+CDFGL R A+ E D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS +D+E I +E R+ L + +KP + ++FP N D +A DL+ +L FNP KR VE+AL H Y+E+++DP
Sbjct: 37 RYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKI-SPFEHQTYCQRTLREITILTRFK-HENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARI----------ADPEHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFP-NADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDP 332
BLAST of Mitogen-activated protein kinase vs. Ensembl Fly
Match: rl (gene:FBgn0003256 transcript:FBtr0113702) HSP 1 Score: 269.24 bits (687), Expect = 3.892e-84 Identity = 146/316 (46.20%), Postives = 199/316 (62.97%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITL---INVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY IG GAYG+V A D + + VA+KKI F+++T QRT REI L F H NII + + V D RD+Y+V LM++DL+ ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL+ C +K+CDFGL R A+ E D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS +D+E I +E R+ L + +KP + ++FP N D +A DL+ +L FNP KR VE+AL H Y+E+++DP
Sbjct: 37 RYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKI-SPFEHQTYCQRTLREITILTRFK-HENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARI----------ADPEHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFP-NADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDP 332
BLAST of Mitogen-activated protein kinase vs. Ensembl Zebrafish
Match: mapk15 (mitogen-activated protein kinase 15 [Source:ZFIN;Acc:ZDB-GENE-050522-307]) HSP 1 Score: 468.003 bits (1203), Expect = 3.756e-159 Identity = 217/366 (59.29%), Postives = 288/366 (78.69%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQ 1142
EVE +I +Y+IK R+G GAYGIVWKA+D+KSGE VA+KKIFDAF+N TDAQRTFREI FLQ+F HPNII L+NV +A ND+DIYL+FE MD+DLH VIK+GNLLK +HK Y++YQ+LKA KY+HSGNVIHRD KPSN+LLDS+C VKLCDFGL RSL+QI+ E G +P LTEYVATRWYRAPEILLGS++YTK VD+WS+GCILAE++LGK LF G+S++NQIEKI++ +P PS ED+ +I+SEY S++ +++ +P +EI PA+V A DL++ LL FNP KR + E+AL H Y+ KFH+P E + ++++ P++D+ QLS+ +YR+KLY+MI +K+A ++ + Q
Sbjct: 5 EVEEHISSKYEIKRRLGKGAYGIVWKAVDRKSGETVAVKKIFDAFRNRTDAQRTFREIMFLQEFGDHPNIIKLLNVIRAQNDKDIYLIFEFMDTDLHAVIKKGNLLKDIHKRYVMYQLLKATKYLHSGNVIHRDQKPSNILLDSDCFVKLCDFGLARSLYQIQ--------EDAG------NPALTEYVATRWYRAPEILLGSSRYTKGVDMWSIGCILAEMLLGKPLFPGTSTINQIEKIMNVIPHPSTEDVLAIRSEYGASVIQRMLLRPQVPLDEILPASVPPDALDLLQRLLLFNPDKRLSAEEALRHPYVSKFHNPSSEPSLLYDVILPVDDDVQLSVTQYRNKLYEMIVEKRASRQMQKQ 356
BLAST of Mitogen-activated protein kinase vs. Ensembl Zebrafish
Match: mapk3 (mitogen-activated protein kinase 3 [Source:ZFIN;Acc:ZDB-GENE-040121-1]) HSP 1 Score: 266.159 bits (679), Expect = 1.211e-82 Identity = 154/362 (42.54%), Postives = 216/362 (59.67%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITL---INVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQA 1145
RY IG GAYG+V A D + VA+KKI F+++T QRT REI L F H NII + + R D RD+Y+V +LM++DL+ ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+L+++ C +K+CDFGL R A+ E D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS++D+ I + R+ L + KP +N++FP D A DL+ +L FNP KR VEQAL H Y+E+++DP E + + P +L D + KL ++I ++ A +A Q
Sbjct: 55 RYTDLQYIGEGAYGMVCSAFDNVNKIRVAIKKI-SPFEHQTYCQRTLREIKILLRFH-HENIIGINDILRARHIDYMRDVYIVQDLMETDLYKLLKTQQL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI----------ADPEHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINMKARNYLQSLPQKPKIPWNKLFP-KADNKALDLLDRMLTFNPLKRINVEQALAHPYLEQYYDPSDEPVAEE----PFTFNMELD-DLPKEKLKELIFEETARFQANYQG 391
BLAST of Mitogen-activated protein kinase vs. Ensembl Zebrafish
Match: mapk1 (mitogen-activated protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030722-2]) HSP 1 Score: 259.225 bits (661), Expect = 3.011e-80 Identity = 142/316 (44.94%), Postives = 198/316 (62.66%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITL---INVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY + IG GAYG+V A D+ + VA+KKI F+++T QRT REI L F H NII + I D +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + + +N +FP N D A DL+ +L FNP KR VE+AL H Y+E+++DP
Sbjct: 33 RYSNLSYIGEGAYGMVCSAYDRDNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIIGINDIIRTPTIDQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARNYLLSLPLRSKVPWNRLFP-NADPKALDLLDKMLTFNPHKRIEVEEALAHPYLEQYYDP 328
BLAST of Mitogen-activated protein kinase vs. Ensembl Zebrafish
Match: mapk1 (mitogen-activated protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030722-2]) HSP 1 Score: 259.225 bits (661), Expect = 3.011e-80 Identity = 142/316 (44.94%), Postives = 198/316 (62.66%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITL---INVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY + IG GAYG+V A D+ + VA+KKI F+++T QRT REI L F H NII + I D +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + + +N +FP N D A DL+ +L FNP KR VE+AL H Y+E+++DP
Sbjct: 33 RYSNLSYIGEGAYGMVCSAYDRDNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIIGINDIIRTPTIDQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARNYLLSLPLRSKVPWNRLFP-NADPKALDLLDKMLTFNPHKRIEVEEALAHPYLEQYYDP 328
BLAST of Mitogen-activated protein kinase vs. Ensembl Zebrafish
Match: mapk1 (mitogen-activated protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030722-2]) HSP 1 Score: 259.225 bits (661), Expect = 3.011e-80 Identity = 142/316 (44.94%), Postives = 198/316 (62.66%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITL---INVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY + IG GAYG+V A D+ + VA+KKI F+++T QRT REI L F H NII + I D +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + + +N +FP N D A DL+ +L FNP KR VE+AL H Y+E+++DP
Sbjct: 33 RYSNLSYIGEGAYGMVCSAYDRDNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIIGINDIIRTPTIDQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARNYLLSLPLRSKVPWNRLFP-NADPKALDLLDKMLTFNPHKRIEVEEALAHPYLEQYYDP 328
BLAST of Mitogen-activated protein kinase vs. Ensembl Xenopus
Match: atxn7 (ataxin 7 [Source:Xenbase;Acc:XB-GENE-956283]) HSP 1 Score: 489.96 bits (1260), Expect = 1.413e-166 Identity = 268/600 (44.67%), Postives = 374/600 (62.33%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEE-IKSLRXXXXXXXX---------------XXXENAMIMEQKIASRA-NYDIAFGRTTHQRP---PPPKNNHASNQSNNPLIGMKAFLTKTENTKIDNSRSRLSHSAFQ-RDDGNSRNETS--FQKKSFGSDVEQKRPSRNVMTCSKEASNPVILRDLHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQFD---NAKNHSNMRSTLGSYSQTYGTVSSSQLNNL 1766
EVE +I ++Y+IK R+G GAYGIVWKAID+KSGE VA+KKIFDAF+N TDAQRTFREI FLQ+F HPNII L+NV +A ND+DIYLVFE M++DLH VIK+GNLL+ +H YI+YQ+LKA K+IHSGNVIHRD KPSN+LLD +C VKLCDFGL RSL+QI+ E G +P LTEYVATRWYRAPEILL S +YTK VD+WSVGCIL E++LGK LF G+S++NQIE+I+S + P+ ED+ +I+SEY S++ ++ K E+FPA+ + A DL+ LL FNP KR T E ALEH Y+ +FH P E +D++++ P++D+ QLS+ EYR+KLY+MI ++K R Q R +E + SL S E + + Q+ A A N A +T Q P P N + + ++ +A + E + N + +A + R + SR+ T+ + +SF + + + N K+ + L + S++A +++ ++ P + RS + FGRK F N ++ + ++TL SY+Q YGT+S S L+NL
Sbjct: 5 EVEDHISQKYEIKKRLGKGAYGIVWKAIDRKSGEIVAVKKIFDAFRNRTDAQRTFREIMFLQEFGEHPNIIKLLNVIRAQNDKDIYLVFEHMETDLHAVIKKGNLLRDIHMRYILYQLLKATKFIHSGNVIHRDQKPSNILLDGDCLVKLCDFGLARSLYQIQ--------EDAG------NPALTEYVATRWYRAPEILLASHRYTKGVDMWSVGCILGEMLLGKPLFPGTSTINQIERIMSIIEPPTHEDILAIRSEYGASVIGRMAAKQRVPLAELFPASCPREALDLLSKLLVFNPGKRLTAEGALEHPYVSRFHSPAREPALDYDVILPVDDDTQLSVAEYRNKLYEMILERKM--NIRRQKREAQKESVSSLASAAEGKQVADTSKHPAAPTGTNPAPQEISSTVPQRAAIAAPNQPPALKDSTQQSPKGKAPSSNPISHSTTHGSSEDWRAAQNRKEGQQNSNQQGAAGSTAQEVRKEAESRSRTAPIGRARSFSHSQQARAAATNSALMRKDGA------PLGTVSVAAVSARLNQRAPPVQGRDQRS-APRFGRKMFQGKTNVESAGDPKATLHSYTQAYGTISKSALHNL 581
BLAST of Mitogen-activated protein kinase vs. Ensembl Xenopus
Match: atxn7 (ataxin 7 [Source:Xenbase;Acc:XB-GENE-956283]) HSP 1 Score: 443.736 bits (1140), Expect = 1.368e-149 Identity = 206/347 (59.37%), Postives = 265/347 (76.37%), Query Frame = 3
Query: 78 IKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKK 1118
I++ IG AYGIVWKAID+KSGE VA+KKIFDAF+N TDAQRTFREI FLQ+F HPNII L+NV +A ND+DIYLVFE M++DLH VIK+GNLL+ +H YI+YQ+LKA K+IHSGNVIHRD KPSN+LLD +C VKLCDFGL RSL+QI+ E G +P LTEYVATRWYRAPEILL S +YTK VD+WSVGCIL E++LGK LF G+S++NQIE+I+S + P+ ED+ +I+SEY S++ ++ K E+FPA+ + A DL+ LL FNP KR T E ALEH Y+ +FH P E +D++++ P++D+ QLS+ EYR+KLY+MI ++K
Sbjct: 43 IRHCIGWAAYGIVWKAIDRKSGEIVAVKKIFDAFRNRTDAQRTFREIMFLQEFGEHPNIIKLLNVIRAQNDKDIYLVFEHMETDLHAVIKKGNLLRDIHMRYILYQLLKATKFIHSGNVIHRDQKPSNILLDGDCLVKLCDFGLARSLYQIQ--------EDAG------NPALTEYVATRWYRAPEILLASHRYTKGVDMWSVGCILGEMLLGKPLFPGTSTINQIERIMSIIEPPTHEDILAIRSEYGASVIGRMAAKQRVPLAELFPASCPREALDLLSKLLVFNPGKRLTAEGALEHPYVSRFHSPAREPALDYDVILPVDDDTQLSVAEYRNKLYEMILERK 375
BLAST of Mitogen-activated protein kinase vs. Ensembl Xenopus
Match: cdknx (cyclin-dependent kinase inhibitor xic1 [Source:Xenbase;Acc:XB-GENE-1032978]) HSP 1 Score: 258.84 bits (660), Expect = 6.912e-80 Identity = 143/323 (44.27%), Postives = 203/323 (62.85%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMD 1028
RY + IG GAYG+V A D + VA+KKI F+++T QRT REI L F H NII + ++ +A + +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + +K +N +FP N D A DL+ +L FNP KR VE AL H Y+E+++DP E + +
Sbjct: 35 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP-NADPKALDLLDKMLTFNPHKRIEVEAALAHPYLEQYYDPSDEPVAE 337
BLAST of Mitogen-activated protein kinase vs. Ensembl Xenopus
Match: cdknx (cyclin-dependent kinase inhibitor xic1 [Source:Xenbase;Acc:XB-GENE-1032978]) HSP 1 Score: 258.07 bits (658), Expect = 9.383e-80 Identity = 142/316 (44.94%), Postives = 200/316 (63.29%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY + IG GAYG+V A D + VA+KKI F+++T QRT REI L F H NII + ++ +A + +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + +K +N +FP N D A DL+ +L FNP KR VE AL H Y+E+++DP
Sbjct: 27 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP-NADPKALDLLDKMLTFNPHKRIEVEAALAHPYLEQYYDP 322
BLAST of Mitogen-activated protein kinase vs. Ensembl Xenopus
Match: cdknx (cyclin-dependent kinase inhibitor xic1 [Source:Xenbase;Acc:XB-GENE-1032978]) HSP 1 Score: 258.07 bits (658), Expect = 1.052e-79 Identity = 142/316 (44.94%), Postives = 200/316 (63.29%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY + IG GAYG+V A D + VA+KKI F+++T QRT REI L F H NII + ++ +A + +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + +K +N +FP N D A DL+ +L FNP KR VE AL H Y+E+++DP
Sbjct: 31 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP-NADPKALDLLDKMLTFNPHKRIEVEAALAHPYLEQYYDP 326
BLAST of Mitogen-activated protein kinase vs. Ensembl Mouse
Match: Mapk15 (mitogen-activated protein kinase 15 [Source:MGI Symbol;Acc:MGI:2652894]) HSP 1 Score: 401.749 bits (1031), Expect = 7.952e-133 Identity = 189/376 (50.27%), Postives = 256/376 (68.09%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDP---TLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEE 1163
EV+ ++ +RY IK R+G GAYGIVWKA+D+++GE VA+KKIFDAF+++ DAQRTFREI L++F GHPNII L++V A NDRDIYLVFE MD+DL+ VI++G LLK +HK I YQ+L+A K+IHSG VIHRD KP+NVLLDS C VKLCDFGL RS LGD P LTEYVATRWYRAPE+LL S YT VD+WS+GCIL E++ G+ LF G+S+ +Q+E I+ +P PS E+++ + S+Y IL + +P + + + P + A DL+K LL F P KR + EQAL+H Y+++FH P+ E + ++ P+++ QLS EYR +LY +I ++ +R P EE
Sbjct: 5 EVDRHVAQRYLIKRRLGKGAYGIVWKAMDRRTGEVVAIKKIFDAFRDQIDAQRTFREIMLLKEFGGHPNIIRLLDVIPAKNDRDIYLVFESMDTDLNAVIQKGRLLKDIHKRCIFYQLLRATKFIHSGRVIHRDQKPANVLLDSACRVKLCDFGLARS-----------------LGDLPEGPGGQALTEYVATRWYRAPEVLLSSRWYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILKTIPLPSMEELQDLGSDYSALILQNLGSRPQQTLDALLPPDTPPEALDLLKRLLAFAPDKRLSAEQALQHPYVQRFHCPDREWARESDVRLPVHEGDQLSAPEYRKRLYQIILEQSG------NSRSPREE 357
BLAST of Mitogen-activated protein kinase vs. Ensembl Mouse
Match: Mapk1 (mitogen-activated protein kinase 1 [Source:MGI Symbol;Acc:MGI:1346858]) HSP 1 Score: 260.766 bits (665), Expect = 7.264e-81 Identity = 145/321 (45.17%), Postives = 203/321 (63.24%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEII 1022
RY + IG GAYG+V A D + VA+KKI F+++T QRT REI L F H NII + ++ +A + +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + +K +N +FP N D A DL+ +L FNP KR VEQAL H Y+E+++DP E I
Sbjct: 22 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP-NADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPI 322
BLAST of Mitogen-activated protein kinase vs. Ensembl Mouse
Match: Mapk1 (mitogen-activated protein kinase 1 [Source:MGI Symbol;Acc:MGI:1346858]) HSP 1 Score: 260.766 bits (665), Expect = 7.264e-81 Identity = 145/321 (45.17%), Postives = 203/321 (63.24%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEII 1022
RY + IG GAYG+V A D + VA+KKI F+++T QRT REI L F H NII + ++ +A + +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + +K +N +FP N D A DL+ +L FNP KR VEQAL H Y+E+++DP E I
Sbjct: 22 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP-NADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPI 322
BLAST of Mitogen-activated protein kinase vs. Ensembl Mouse
Match: Mapk1 (mitogen-activated protein kinase 1 [Source:MGI Symbol;Acc:MGI:1346858]) HSP 1 Score: 260.766 bits (665), Expect = 7.264e-81 Identity = 145/321 (45.17%), Postives = 203/321 (63.24%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEII 1022
RY + IG GAYG+V A D + VA+KKI F+++T QRT REI L F H NII + ++ +A + +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + +K +N +FP N D A DL+ +L FNP KR VEQAL H Y+E+++DP E I
Sbjct: 22 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP-NADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPI 322
BLAST of Mitogen-activated protein kinase vs. Ensembl Mouse
Match: Mapk3 (mitogen-activated protein kinase 3 [Source:MGI Symbol;Acc:MGI:1346859]) HSP 1 Score: 259.61 bits (662), Expect = 3.931e-80 Identity = 142/320 (44.38%), Postives = 200/320 (62.50%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEI 1019
RY IG GAYG+V A D VA+KKI F+++T QRT REI L F H N+I + ++ +A + RD+Y+V +LM++DL+ ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+L+++ C +K+CDFGL R A+ E D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + K + ++FP + D A DL+ +L FNP KR TVE+AL H Y+E+++DP E+
Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLK-SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI----------ADPEHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS-DSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEV 341
BLAST of Mitogen-activated protein kinase vs. UniProt/SwissProt
Match: sp|Q501Q9|MK15_XENLA (Mitogen-activated protein kinase 15 OS=Xenopus laevis OX=8355 GN=mapk15 PE=1 SV=1) HSP 1 Score: 488.034 bits (1255), Expect = 3.525e-165 Identity = 268/613 (43.72%), Postives = 375/613 (61.17%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEEIKSLRXXXXXXXXXXXENAMIMEQKIASRANYDIAFGRT-THQRPPPPKNNHASNQSNNPLIGMKAFL-----------TKTENTKIDNSRSR-LSHSAFQ---RDDGNSRNETSFQKKSFGSDVEQKRP-----SRNV-----------MTCSKEASNPVILRD----LHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQFD---NAKNHSNMRSTLGSYSQTYGTVSSSQLNNL 1766
EVE +I ++YDIK R+G GAYGIVWKAID+KSGE VA+KKIFDAF+N TDAQRTFREI FLQ+F HPNII L+NV +A ND+DIYLVFE M++DLH VIK+GNLLK +H YI+YQ+LKA K+IHSGNVIHRD KPSN+LLD +C VKLCDFGL RSL+QI+ + +G+ P LTEYVATRWYRAPEILL S +YTK VD+WSVGCIL E++LGK LF G+S++NQIE+I+S + P+ ED+ SIKSEY S+++++ K E+FPA+ + A DL+ LL FNP KR T E+ALEH Y+ +FH P E +D++++ P++D+ QLS+ EYR+KLY+MI ++K RR E +++ ++S AN T T + P PP + + Q + + +A + + ++ KI S ++HS D S N+ + Q+ + G+ ++ R SR A+N ++R + S++A +++ ++ P + RS + FGRK F N ++ + ++TL SY+Q YGT+S + L NL
Sbjct: 5 EVEDHISQKYDIKKRLGKGAYGIVWKAIDRKSGEIVAVKKIFDAFRNRTDAQRTFREIMFLQEFGEHPNIIKLLNVIRAQNDKDIYLVFEHMETDLHAVIKKGNLLKDIHMRYILYQLLKATKFIHSGNVIHRDQKPSNILLDGDCLVKLCDFGLARSLYQIQ----------EDVGN----PALTEYVATRWYRAPEILLASNRYTKGVDMWSVGCILGEMLLGKPLFPGTSTINQIERIMSIIEPPTHEDIVSIKSEYGASVISRMSSKHKVPMAELFPASCPREALDLLSKLLVFNPGKRLTAEEALEHPYVSRFHSPAREPALDYDVILPVDDDIQLSVAEYRNKLYEMILERK------MNIRRQKRES--------------------LKESVSSSANGAKDRQDTDTSKTPAPPAGTNPAPQPTSSTVPQRAAIAAPNQPPAQKDSTQQSPKIKAPSSNPITHSTTHGSTEDWRTSHNKKAGQQGAAGTTAQEVRKEVESRSRTAPIGRARSFSHSQQARAAATNSALIRKDAPPTGTVSVAAVSARLNQRTAPIQGRDPRS-APRFGRKMFQGKTNVESAGDPKATLHSYTQAYGTISKAALQNL 576
BLAST of Mitogen-activated protein kinase vs. UniProt/SwissProt
Match: sp|Q11179|MK15_CAEEL (Mitogen-activated protein kinase 15 OS=Caenorhabditis elegans OX=6239 GN=mapk-15 PE=1 SV=2) HSP 1 Score: 444.121 bits (1141), Expect = 1.218e-149 Identity = 207/380 (54.47%), Postives = 285/380 (75.00%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAE-KEARTQARRPNEEIKS 1172
MT++V+++I +++D++ R+G GAYGIVWKA DK+S E VALKKIFDAF+N TD+QRTFRE+ FLQ+F HPN+I L N+ +ADNDRDIYL FE M++DLHNVIK+G++LK VHK+YI+ Q+ +A++++HSGNV+HRDLKPSNVLLD++C VKL DFGL RSL +E +P+ K P LTEYVATRWYR+PEILL + +YTK VD+WS+GCILAE+++G+ALF GSS++NQIE+I++ + +PS D+ SI S Y S+L ++ +P K + I A D+V+ LL F P+KR TVEQ L H Y+ +FH+P E ++++E+ PP+ D QLSID+YR +LY+MI +KKA K + + RP E KS
Sbjct: 1 MTDDVDTHIHEKFDLQKRLGKGAYGIVWKAYDKRSRETVALKKIFDAFRNPTDSQRTFREVMFLQEFGKHPNVIKLYNIFRADNDRDIYLAFEFMEADLHNVIKKGSILKDVHKQYIMCQLFRAIRFLHSGNVLHRDLKPSNVLLDADCRVKLADFGLARSLSSLED-YPEGQKM----------PDLTEYVATRWYRSPEILLAAKRYTKGVDMWSLGCILAEMLIGRALFPGSSTINQIERIMNTIAKPSRADIASIGSHYAASVLEKMPQRPRKPLDLII-TQSQTAAIDMVQRLLIFAPQKRLTVEQCLVHPYVVQFHNPSEEPVLNYEVYPPLPDHIQLSIDDYRDRLYEMIDEKKASFKRIQHEKIRPYGEDKS 368
BLAST of Mitogen-activated protein kinase vs. UniProt/SwissProt
Match: sp|Q8TD08|MK15_HUMAN (Mitogen-activated protein kinase 15 OS=Homo sapiens OX=9606 GN=MAPK15 PE=1 SV=1) HSP 1 Score: 405.986 bits (1042), Expect = 9.014e-134 Identity = 183/362 (50.55%), Postives = 258/362 (71.27%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDP---TLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQ 1112
M V+ I++RY ++ ++G GAYGIVWKA+D+++GE VA+KKIFDAF+++TDAQRTFREI LQ+F HPNII+L++V +A+NDRDIYLVFE MD+DL+ VI++G LL+ VH I YQ+L+A +++HSG+V+HRD KPSNVLLD+NCTVKLCDFGL RS LGD P +TEYVATRWYRAPE+LL S +YT VD+WS+GCIL E++ G+ LF G+S+L+Q+E I+ +P PSEED+ ++ S S+L+Q+ +P + + + P + A DL++ LL F P KR + QAL+H Y+++FH P E + ++ P ++ QLS+ EYRS++Y MI +
Sbjct: 1 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARS-----------------LGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
BLAST of Mitogen-activated protein kinase vs. UniProt/SwissProt
Match: sp|Q9Z2A6|MK15_RAT (Mitogen-activated protein kinase 15 OS=Rattus norvegicus OX=10116 GN=Mapk15 PE=1 SV=2) HSP 1 Score: 403.29 bits (1035), Expect = 1.434e-132 Identity = 190/376 (50.53%), Postives = 258/376 (68.62%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDP---TLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEE 1163
EV+ ++ +RY IK R+G GAYGIVWKA+D+++GE VA+KKIFDAF+++TDAQRTFREI L++F GHPNII L++V A NDRDIYLVFE MD+DL+ VI++G LL+ +HK I YQ+L+A K+IHSG VIHRD KP+NVLLD+ C VKLCDFGL RS L DF P LTEYVATRWYRAPE+LL S YT VD+WS+GCIL E++ G+ LF G+S+ +Q+E I+ +P PS E+++ + S+Y IL + +P + + + P + A DL+K LL F P KR + EQAL+H Y+++FH P+ E ++ P+++ QLS EYR++LY MI ++ R +R P EE
Sbjct: 5 EVDRHVSQRYLIKRRLGKGAYGIVWKAMDRRTGEVVAIKKIFDAFRDQTDAQRTFREIMLLREFGGHPNIIRLLDVIPAKNDRDIYLVFESMDTDLNAVIQKGRLLEDIHKRCIFYQLLRATKFIHSGRVIHRDQKPANVLLDAACRVKLCDFGLARS-----------------LSDFPEGPGGQALTEYVATRWYRAPEVLLSSRWYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILETIPLPSMEELQGLGSDYSALILQNLGSRPRQTLDALLPPDTPPEALDLLKRLLAFAPDKRLSAEQALQHPYVQRFHCPDREWTRGSDVRLPVHEGDQLSAPEYRNRLYQMILER------RRNSRSPREE 357
BLAST of Mitogen-activated protein kinase vs. UniProt/SwissProt
Match: sp|Q80Y86|MK15_MOUSE (Mitogen-activated protein kinase 15 OS=Mus musculus OX=10090 GN=Mapk15 PE=1 SV=1) HSP 1 Score: 401.749 bits (1031), Expect = 5.562e-132 Identity = 189/376 (50.27%), Postives = 256/376 (68.09%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDP---TLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEE 1163
EV+ ++ +RY IK R+G GAYGIVWKA+D+++GE VA+KKIFDAF+++ DAQRTFREI L++F GHPNII L++V A NDRDIYLVFE MD+DL+ VI++G LLK +HK I YQ+L+A K+IHSG VIHRD KP+NVLLDS C VKLCDFGL RS LGD P LTEYVATRWYRAPE+LL S YT VD+WS+GCIL E++ G+ LF G+S+ +Q+E I+ +P PS E+++ + S+Y IL + +P + + + P + A DL+K LL F P KR + EQAL+H Y+++FH P+ E + ++ P+++ QLS EYR +LY +I ++ +R P EE
Sbjct: 5 EVDRHVAQRYLIKRRLGKGAYGIVWKAMDRRTGEVVAIKKIFDAFRDQIDAQRTFREIMLLKEFGGHPNIIRLLDVIPAKNDRDIYLVFESMDTDLNAVIQKGRLLKDIHKRCIFYQLLRATKFIHSGRVIHRDQKPANVLLDSACRVKLCDFGLARS-----------------LGDLPEGPGGQALTEYVATRWYRAPEVLLSSRWYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILKTIPLPSMEELQDLGSDYSALILQNLGSRPQQTLDALLPPDTPPEALDLLKRLLAFAPDKRLSAEQALQHPYVQRFHCPDREWARESDVRLPVHEGDQLSAPEYRKRLYQIILEQSG------NSRSPREE 357
BLAST of Mitogen-activated protein kinase vs. TrEMBL
Match: A0A1S3JU08 (Mitogen-activated protein kinase OS=Lingula unguis OX=7574 GN=LOC106176147 PE=4 SV=1) HSP 1 Score: 542.732 bits (1397), Expect = 0.000e+0 Identity = 280/595 (47.06%), Postives = 387/595 (65.04%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEK--------EARTQARR--PNEEIKSLRXXXXXXXXXXXENAMIM---EQKIASRANYDIAFGRTTHQRPPPPKNNHASNQSNNPLIGMKAFLTKTENTKIDNSRSRLSHSAFQRDDGNSRNETSFQKKSFGSDVEQKRPSRNVMTCSKEASNPVILRDLHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQFDNAKN---HSNMRSTLGSYSQTYGTVSSSQLNNLYS 1772
M++E+E ++ K+Y++K R+G GAYGIVWKA+DK++GE VALKKIFDAF+N+TDAQRTFREI FLQ+F HPNI+ L NV KA+ND+DIYLVFE MD+DLHNVIK+GN+LK +HK YI+YQ+LKA KY+HSGNVIHRD KPSNVLLD C VK+CDFGL RSL Q+E D TDP LTEYVATRWYRAPEILL S +YTK VD+WS+GCIL E++LGK LF GSS+LNQIEKI+S++ PS+ D+ES+KS Y SIL++ +P K ++ P + + A DL+K LL FNP KR T E+AL+H Y+++FH PE E+ + ++VPP++D+ QLS++EYR+KLY+MI +KKAE+ E++ Q + P+E + S + ++ + + Q ++ +AFGRTTH PP +Q L +++ EN H + D N + E GS R +R ++NP+I RD T ++ + +++ RP+SA+ + +FGRKQFDN +N H + ++ GSY+Q +GT+S+ L+ L S
Sbjct: 1 MSSEIEPHVTKKYEVKKRLGKGAYGIVWKAVDKRTGEVVALKKIFDAFRNQTDAQRTFREIMFLQEFGDHPNIVKLHNVMKAENDKDIYLVFEFMDTDLHNVIKKGNILKDIHKRYIMYQLLKATKYMHSGNVIHRDQKPSNVLLDGECFVKVCDFGLARSLTQLEM-------------DEGTDPNLTEYVATRWYRAPEILLASHRYTKGVDMWSLGCILGELLLGKPLFPGSSTLNQIEKIMSSITPPSKSDIESLKSAYGASILDKAAIRPKKPMEDLLP-DAPKDAIDLLKKLLHFNPDKRLTAEEALKHPYVQRFHSPEDELDIGRDVVPPLSDDVQLSVEEYRNKLYEMIMEKKAERRTKRKEEEESKVQKEQVPPSEPLPSQANGYLSNGASPKVATPVTVRPAQPQTTQPAPVVAFGRTTHPNPP-------QSQVKKALPRQRSY----ENV----------HGGEKGDSPNVKKERQ------GSAPAAGRHARTTSAGMFRSNNPIITRD-DKTGLAISSSRIVPGQRPSSAKEGQRTKPSFGRKQFDNVRNNPSHGHTKAAFGSYTQNFGTISNKALSTLKS 553
BLAST of Mitogen-activated protein kinase vs. TrEMBL
Match: A0A210PNM3 (Mitogen-activated protein kinase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT09106 PE=4 SV=1) HSP 1 Score: 514.227 bits (1323), Expect = 1.214e-172 Identity = 276/599 (46.08%), Postives = 379/599 (63.27%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEK--------------EARTQARRPNEEIKSLRXXXXXXXXXXXENAMIMEQKIASRANYD---IAFGRTTH--QRPPPPKNNHASNQSNNPLIGMKAFLTKTENTKIDNSRSRLSHSAFQRDDGNSRNETSFQKKSFGSDVEQKRPSRNVMTCSKEASNPVILRDLHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQFDNAKNHSNM---RSTLGSYSQTYGTVSSSQLNNL 1766
M +E+E +I K+Y+IK R+G GAYGIVWKA+D+++GE VA+KKIFDAF+N+TDAQRTFREI FLQ+F HPNII L NV KA+ND+DIYLVFE M++DLHNVIKRG++L+ VHK YI+YQ+LKA KY+HSGNVIHRD KPSNVLLDS+C VK+CDFGL RSL QI G+ DP LTEYVATRWYRAPEILL S +YTK VD+WS+GCIL E++ GK LF GSS+LNQIEKI+ +P P+ ED+ES++S Y S+L + KP K F ++ P +V + A DL++ LL FNP KR T ++ L H Y+ +FH+P E +D+++VPP++D+ QL++DEYR+KLY+MI QKK E+ RT++ P E ++ N + S + AFGRTTH Q PP PK+ + +N EN + + + ++H + N R ++ GS RP ++ + NP I RD S+ ++ T +++ RP+SA + + +G+KQ+ NA N+ + ++ GSY+Q GT+SSS L +L
Sbjct: 33 MNSEIEPHISKKYEIKKRLGKGAYGIVWKAVDRRTGEVVAVKKIFDAFRNQTDAQRTFREIMFLQEFGDHPNIIKLHNVIKAENDKDIYLVFEFMETDLHNVIKRGSILRDVHKRYIMYQLLKATKYLHSGNVIHRDNKPSNVLLDSDCVVKVCDFGLARSLTQI------------GIDAETGDPNLTEYVATRWYRAPEILLASHRYTKGVDMWSLGCILGELLGGKPLFPGSSTLNQIEKIMGGIPVPTREDIESLQSAYGSSVLGKASVKPKKSFEDMLP-DVPKEALDLLRRLLHFNPDKRITADEGLRHPYVSRFHNPAEERSIDYDVVPPLSDDVQLTVDEYRNKLYEMIMQKKQERRRRRQEMRSAPHPMRVRTESPHPPSEPYHKDNSPKGASPKVYNNKHAGDGPPQSAPQHHSSFSAFGRTTHGDQVPPQPKSRNVRRPNN-------------ENMERAATNAGMAHDPYPAMSKN-RQASAPAASRMGS-----RP----ISGAYGVKNPTITRDEKSSGLAVTSSRMVPGQRPSSATNQQQRKPLYGKKQYSNAINNPSAGSHKAYFGSYNQNVGTISSSALASL 595
BLAST of Mitogen-activated protein kinase vs. TrEMBL
Match: A0A433SZV9 (Mitogen-activated protein kinase OS=Elysia chlorotica OX=188477 GN=EGW08_017412 PE=3 SV=1) HSP 1 Score: 504.212 bits (1297), Expect = 3.410e-169 Identity = 278/610 (45.57%), Postives = 373/610 (61.15%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPG---KKFNEIFP-ANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEEIKS--LRXXXXXXXXXXXENAMIMEQKIASRANYDI---------------AFGRTT---HQRPPPPKNNHASNQSNNPLIGMKAFLTKTENTKIDNSRSRLSHSAFQRDDGNSRNETSFQKKSFGSDVEQKRPSRNVMTCSKEASNPVILRD---LHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQFDNAKNHSNM---RSTLGSYSQTYGTVSSSQLNNLYSR 1775
M++E+E +I K+Y+IK R+G GAYGIVWKAID++SGE VA+KKIFDAF+N+TDAQRTFREI FLQ+F HPN+I L NV KA+ND+DIYLVFE M++DLHNVIKRGN+LK VHK YI+YQ+ K+ KY+HSGNVIHRDLKPSN+LLDS C VKLCDFGL RSL QI D DP LTEYVATRWYRAPEILL S +YTK VD+WS+GCIL E++LGK LF GSS+LNQIE+I+ ++P PS D++S+KS Y S+L + G K F+EI P + D V DL+K LL FNP KR T ++AL H ++ +FH+P EI ++ ++VPP++D+ QL++DEYRSKLY+MI QKKAE+ R + + ++ + D + + EN ++ + +A + AFGR+ HQ+ P + S Q RS + Q +G+ S + + + + R + SNP I R+ + + +++ RP SA + R+ +GRKQF NA N + ++ GSYSQ YGT+SSS L L R
Sbjct: 1 MSSEIEPHITKKYEIKKRLGKGAYGIVWKAIDRRSGEVVAVKKIFDAFRNQTDAQRTFREIMFLQEFGDHPNVIKLHNVIKAENDKDIYLVFEFMETDLHNVIKRGNILKDVHKRYIMYQLFKSTKYLHSGNVIHRDLKPSNILLDSECVVKLCDFGLARSLTQIAM-------------DEAGDPNLTEYVATRWYRAPEILLASHRYTKGVDMWSLGCILGEMLLGKPLFPGSSTLNQIERIMGSIPTPSRADVDSLKSSYGASVLEKAASAAGRHKKTFDEILPDSPADGV--DLMKKLLHFNPDKRITADEALRHPFVHRFHNPAGEISLNFDVVPPLSDDVQLTVDEYRSKLYEMIIQKKAERRRRRREEARSAALQQEDYVAGDIPSEPPAKENIHASPKRPSPKAAHKYGQIGDHPSHHHSSFSAFGRSATHDHQQAGPSRQKALSRQ-----------------------RSYENIQGSQAANGDPYPPLSQKGRQTSAPAAMRGQGRPASGVYRAQSNPTITREERAANGGGLMVASSRMVPGQRPTSATNPRAKP-VYGRKQFSNATNAPSSGAPKAVFGSYSQAYGTISSSSLAALQGR 571
BLAST of Mitogen-activated protein kinase vs. TrEMBL
Match: A0A4S2MDY9 (Mitogen-activated protein kinase OS=Opisthorchis felineus OX=147828 GN=CRM22_000747 PE=3 SV=1) HSP 1 Score: 503.442 bits (1295), Expect = 1.890e-168 Identity = 278/618 (44.98%), Postives = 390/618 (63.11%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTR--------SLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEEIKSLRXXXXXXXXXXXENAMIMEQKIASRANYDIAFGRTTHQRP-PPPKNNHASNQSNNPLIGMKAFLTKTENTKIDNSRSRLSHSAFQRDDGNSRNETSFQKKSFGSDVEQKRPSRN--------------------VMTCSKEASNPVILRDLHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQ--------FDNAKNHSNMRSTLGSYSQTYGTVSSSQLNNLYSRNCVR 1787
EVE I++ Y+I R+G GAYGIVW+A +KK+G VALKKIFDAF+N+ DAQRTFREI FLQ+F+GHPNII L+NV KA+NDRDIYLVFE M++DLHN IK+GN+LK +HK YI YQ+L+AVK+IHS NVIHRDLKPSNVLLDS+C VKLCDFGLTR S ES+ A+ ++DG DP LTEYVATRWYRAPEILL S +YTK VD+WS+GCILAE+++GK +F G+S++NQIE+IVSA+PRP+ +D+ ++ S+Y S+L + + KP + +FP V++ A ++ K+LLQ NP KR TVE+AL+H Y+++F D + E++MDH + PP+ND QLS+ +YR+KLY++I +K+A+++ R + R +E +S + T++T + + + ++ + +G + + P P + N +NQ + + TE TK +R S + +S+N S + K + V + P RN + + S+E NPVILR L S T + R ++ + +N+ G Q ++ S LGSYSQTYGTVS SQL+ L SR R
Sbjct: 5 EVEPTILRTYEINKRLGKGAYGIVWRAKNKKTGSTVALKKIFDAFRNQIDAQRTFREITFLQEFAGHPNIIRLLNVIKAENDRDIYLVFEFMETDLHNCIKKGNILKEIHKTYIFYQLLRAVKFIHSANVIHRDLKPSNVLLDSDCHVKLCDFGLTRSLSSPSTGSSFSAESV---ADADSDG-----GDPELTEYVATRWYRAPEILLASNRYTKFVDMWSLGCILAEMLIGKPIFPGTSTINQIERIVSAVPRPNRQDILALHSDYGMSVLEEALRKPSSTLDSLFPETVERNAVEMAKHLLQLNPSKRLTVEKALDHPYVQRFRDRQSELVMDHPVTPPLNDNQQLSVSDYRTKLYEVILEKRAQRKIR-RLLRSVQETESHQKTESTQEKSLKHSGPTSDEGTQTTPELSATYGSSKYVVPYRPAEMNGRANQRGHRERNETNYQNITE-TKASPARKHAHFSPTTQSPQSSKNPES-RTKGLKNGVHEV-PQRNRVGNREIDYVSSNAKSVQCPLRSYSREFDNPVILRSLSGLS---TNPRNLEGHRAIESRQLHANAKKDGVHQSLTPFTAVSPAGDAYTKGVSQLGSYSQTYGTVSRSQLSQLQSRQWTR 607
BLAST of Mitogen-activated protein kinase vs. TrEMBL
Match: A0A4E0R941 (Mitogen-activated protein kinase OS=Fasciola hepatica OX=6192 GN=D915_005701 PE=3 SV=1) HSP 1 Score: 498.049 bits (1281), Expect = 4.497e-166 Identity = 284/634 (44.79%), Postives = 381/634 (60.09%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDF---NTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEEIKSLRXXXXXXXXXXXENAMIMEQKIASRANYDIAFGRTTHQRPPPPKNNHASNQSNNPLIGMKAFLTKT-EN--------------TKIDNSRSRLSHSA----------------------------------FQRDDGNSRNETSFQKKSFGSDVEQKRPSRNVMTCSKEASNPVILRDLHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQFDNAKNHSNMRSTL-GSYSQTYGTVSSSQLNNLYSRNCVR 1787
E+E+ I+K YDI R+G GAYGIVW+A +KK+G VALKKIFDAF+N+TDAQRTFREI FLQ F+GHPNII L+NV KADN++DIYLVFE MDSDLHN IK+GN+LK VHK+YI YQ+L+AVKYIHS +VIHRDLKPSNVLLDS+C VK+CDFGLTRSL ++H + D DP LTEYVATRWYRAPEILL S++YTK VD+WS+GCIL E++ GK +F GSS++NQIE+IVS + +P++ED+ S+ SEY RSIL + KP +F +VD+ A DLVK LL NP KR TVE+AL HAY++KF DP E++MDH + PP++D+ QLS+ EY+ KLY++I +KKA++ + R L + ++ +S+EN + SR YD R+T R P N + + LI + + +T EN I R+ H++ + +GN ++T++ KS + R + S+E NPVILR + +TGN+ + A + + + D + H + S + GSY+QTYGTVS SQL + SR R
Sbjct: 5 EIENTILKHYDIVKRLGKGAYGIVWRAKNKKNGNTVALKKIFDAFRNQTDAQRTFREITFLQAFAGHPNIIRLLNVIKADNNKDIYLVFEHMDSDLHNCIKKGNILKDVHKKYIFYQLLRAVKYIHSADVIHRDLKPSNVLLDSDCLVKVCDFGLTRSL---AAIHGGFRGSVESFSDAAVNGGDPELTEYVATRWYRAPEILLASSRYTKFVDMWSLGCILGEMLSGKPIFPGSSTINQIERIVSVVDKPTDEDIASLHSEYGRSILAKAFQKPRSHIEALFRTDVDRNAIDLVKKLLVLNPSKRLTVEEALNHAYVKKFRDPSSEMVMDHVVTPPLSDDLQLSVAEYQQKLYEIILEKKAQRRIQRMLR-----TVKLDEENGLNELSSTENETLSR----SRTTYD---DRSTEGRFPDKSENRSRSPIREQLINRRGIINETNENGSMITDDFQTTWHPATIQTQNHRVPHASDVSPKISKHTSNTDNKMYRAENHHDSTMLKQLLPESKLNGNLTDKTAYSAKSRNFNRNPLRSPVKPQSYSRELDNPVILRS--QFRVGSTGNRRNRHQISAFPESKVPQRVSSMHRVGDVS--HKFIGSLVPGSYAQTYGTVSRSQLAQIQSRQWTR 619
BLAST of Mitogen-activated protein kinase vs. Ensembl Cavefish
Match: mapk15 (mitogen-activated protein kinase 15 [Source:NCBI gene;Acc:103028638]) HSP 1 Score: 473.011 bits (1216), Expect = 8.666e-160 Identity = 212/375 (56.53%), Postives = 289/375 (77.07%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEK--EARTQARRPNEE 1163
E+E +I +Y+IK R+G GAYGIVWKA+D+K+GE VA+KKIFDAF+N TDAQRTFREI FLQ+F H NII L+NV +A ND+DIYLVFE MD+DLH VIK+GNLLK +HK+YI+YQ+LKA KY+HSGNVIHRD KPSN+LLD++C +KLCDFGL RSL+Q++ + +P LTEYVATRWYRAPEILLGST+YTK VD+WS+GCIL E++LG+ LF G+S++NQIEKI+ A+P P+ ED+ +I+SEY S++ +++ +P ++ +V A DL+++LL FNP KR T EQAL+H Y+ KFH+P E +D++++ P++D+ QLS+ +YR+KLY+MI +K+A + E R ++ EE
Sbjct: 5 ELEEHITLKYEIKRRLGKGAYGIVWKAVDRKTGETVAVKKIFDAFRNRTDAQRTFREIMFLQEFGDHANIIKLLNVIRAQNDKDIYLVFEYMDTDLHAVIKKGNLLKDIHKQYIMYQLLKATKYLHSGNVIHRDQKPSNILLDADCFIKLCDFGLARSLYQMQ--------------EDVANPALTEYVATRWYRAPEILLGSTRYTKGVDMWSIGCILGEMLLGRPLFPGTSTINQIEKIMGAIPHPTAEDVFAIRSEYGASVIQRMLLRPQVPLGDLLQPSVPPDALDLLQHLLVFNPYKRLTAEQALQHPYVAKFHNPAREPSLDYDVILPVDDDVQLSVAQYRNKLYEMILEKRATRQIERRVHLKKQTEE 365
BLAST of Mitogen-activated protein kinase vs. Ensembl Cavefish
Match: mapk3 (mitogen-activated protein kinase 1 [Source:NCBI gene;Acc:103041389]) HSP 1 Score: 266.929 bits (681), Expect = 6.859e-83 Identity = 154/362 (42.54%), Postives = 218/362 (60.22%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITL---INVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQA 1145
RY IG GAYG+V A D + VA+KKI F+++T QRT REI L F H NII + + R+ D RD+Y+V +LM++DL+ ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+L+++ C +K+CDFGL R A+ E D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS++D+ I + R+ L + KP +N++FP D A DL+ +L FNP KR TVE+AL H Y+E+++DP E + + P +L D + KL ++I ++ A +A Q
Sbjct: 55 RYTDLQYIGEGAYGMVCSAFDNVNKIRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HENIIGINDILRARRIDYMRDVYIVQDLMETDLYKLLKTQQL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI----------ADPEHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQDDLNCIINMKARNYLQSLPQKPKIPWNKLFP-KADNKALDLLDRMLTFNPIKRITVEEALAHPYLEQYYDPTDEPVAEE----PFTFNMELD-DLPKEKLKELIFEETARFQANYQG 391
BLAST of Mitogen-activated protein kinase vs. Ensembl Cavefish
Match: mapk1 (mitogen-activated protein kinase 1 [Source:NCBI gene;Acc:103047585]) HSP 1 Score: 261.151 bits (666), Expect = 5.076e-81 Identity = 142/316 (44.94%), Postives = 202/316 (63.92%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY + IG GAYG+V A D+ + VA+KKI F+++T QRT REI L F H NII++ ++ +A D +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + + +N +FP N D A DL+ +L FNP KR VE+AL H Y+E+++DP
Sbjct: 35 RYTNLSYIGEGAYGMVCSAYDRDNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIISINDIIRAPSIDQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARNYLLSLPLRCKVPWNRLFP-NADPKALDLLDKMLTFNPHKRIEVEEALAHPYLEQYYDP 330
BLAST of Mitogen-activated protein kinase vs. Ensembl Cavefish
Match: mapk1 (mitogen-activated protein kinase 1 [Source:NCBI gene;Acc:103047585]) HSP 1 Score: 261.536 bits (667), Expect = 1.083e-80 Identity = 143/320 (44.69%), Postives = 204/320 (63.75%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEI 1019
RY + IG GAYG+V A D+ + VA+KKI F+++T QRT REI L F H NII++ ++ +A D +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + + +N +FP N D A DL+ +L FNP KR VE+AL H Y+E+++DP E+
Sbjct: 35 RYTNLSYIGEGAYGMVCSAYDRDNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIISINDIIRAPSIDQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARNYLLSLPLRCKVPWNRLFP-NADPKALDLLDKMLTFNPHKRIEVEEALAHPYLEQYYDPTDEV 334
BLAST of Mitogen-activated protein kinase vs. Ensembl Cavefish
Match: zgc:171775 (mitogen-activated protein kinase 12-like [Source:NCBI gene;Acc:103042110]) HSP 1 Score: 236.884 bits (603), Expect = 7.753e-72 Identity = 126/354 (35.59%), Postives = 203/354 (57.34%), Query Frame = 3
Query: 57 NIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADND----RDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPIND---ECQLSIDEYRSKLY 1097
++ RY N IG GAYG V AID+K+ E VA+KK++ F++ A+R +RE+ L+ H N+I L+NV D+ + YLV + DL +++K+ L + V Y+ YQ+L+ +KYIHS +IHRDLKP+N+ +D NC +K+ DFGL R + + +T YV TRWYRAPE++ YT++VD+WS GCILAE++ G+ LF G+ S++Q+ I+ P+ ++ ++S+ RS + + + K F ++FP +D D+++ L +P RFT + L H Y+ +FHDPE E PP +D +L+++E++S ++
Sbjct: 20 DVPDRYTSLNSIGSGAYGTVCSAIDQKTKEKVAIKKLYRPFQSLIHAKRAYRELRLLRHIQ-HDNVICLLNVFTPDSSLETFQTFYLVMPFVAQDLGHIMKKRRLSERV-IVYLFYQLLRGLKYIHSAGIIHRDLKPNNLAVDENCELKILDFGLAR----------------------HAEMEMTGYVVTRWYRAPEVIFNWMHYTQTVDIWSAGCILAEMITGQVLFPGNDSMDQLNMILELTGTPNSSLVQKMQSKDARSYVQSLPVQKKKDFRKVFP-TMDPCTVDVLEKTLMLDPESRFTAKDGLSHPYLNEFHDPENE-----PESPPYDDSFESLELAVNEWKSLIH 343
BLAST of Mitogen-activated protein kinase vs. Ensembl Sea Lamprey
Match: mapk15 (mitogen-activated protein kinase 15 [Source:ZFIN;Acc:ZDB-GENE-050522-307]) HSP 1 Score: 445.277 bits (1144), Expect = 2.101e-150 Identity = 257/606 (42.41%), Postives = 376/606 (62.05%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQ-RTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAE--KEARTQARRPNEEIKSLRXXXXXXXXXXXENAMIMEQKIASRANYDIAFGRTTHQRPPPPKN--------NHASNQSNNPLIGMKAFLTKTENTKIDNSRSRLSHSAFQRDDGNSR----NETSFQKKSFGS----DVEQKRPSRNVMTCSKE---------ASNPVILRDLH---STSISATGNKVSMQSRPASAQHVRSNSATFGRKQFDNAKN---HSNMRSTLGSYSQTYGTVSSS 1751
M +++S+I+ +YDIK R+G G GIVWK +D+K+G+ VA+KKIFDAF+N+TDAQ RTFREI FLQ+F HPNII L NV +ADND+DIYLVF+ MD+DLH VI++GN+LK VHK YI YQ+LKA KYIHSGNVIHRD KPSNVLLD C VKLCDFGL RSL QI D DP LTEYVATRWYRAPEILL S +YTK VD+WSVGCI+ E++LGKA+F G+S+LNQIE+I+S +P+PS+ED+ +IKSEY S+L + + + + + P N A DL+K LL FNP KR T E+AL H Y+ +FH+P+ E+ +D+++V P++D+ +LS+ EYR+KLY++I ++K + K + ++P A + QK + +AF ++P ++ H ++ P +G+ + + K S + ++H+A Q + R +E + + + GS +++R +++ C ++ A N +++R+ +S +G ++ + + AS + R+ F RK F+ AKN + ++ +GSYSQ+YGT++ S
Sbjct: 2 MNTDIDSHILLKYDIKKRLGKGELGIVWKGVDRKNGDVVAIKKIFDAFRNQTDAQQRTFREIIFLQEFGDHPNIINLRNVLRADNDKDIYLVFDFMDTDLHAVIRKGNILKDVHKAYITYQLLKATKYIHSGNVIHRDQKPSNVLLDGECFVKLCDFGLARSLKQIR--------------DEPGDPALTEYVATRWYRAPEILLASPRYTKGVDMWSVGCIVGEMLLGKAIFPGTSTLNQIERIMSVIPQPSKEDVLAIKSEYGGSVLEK-MGRQRQSLESLLP-NAPPNALDLLKRLLVFNPEKRLTAEEALGHPYVAQFHNPQTELAVDYDVV-PVDDDTRLSVAEYRNKLYELILERKMDVRKHRKDDQKQP--------------------AASQVAQK-----QHHVAF-HDAQKQPAASQDAQKQHAAVGHQASSRGAPGLGVSCGVP-LASPKGKASVNPITHAADQERPSHWRRTRQSEPTGKSGTGGSVAPLAAKEEREAKSAPACREKSLAQQHRANAGNRMLMREEARELDLGMSVSGAPLNQRGQSAS-RDTRAAGTRFSRKVFEGAKNVGAAGDPKAAMGSYSQSYGTINQS 562
BLAST of Mitogen-activated protein kinase vs. Ensembl Sea Lamprey
Match: mapk15 (mitogen-activated protein kinase 15 [Source:ZFIN;Acc:ZDB-GENE-050522-307]) HSP 1 Score: 427.557 bits (1098), Expect = 4.911e-144 Identity = 209/356 (58.71%), Postives = 271/356 (76.12%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQ-RTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYD 1100
M +++S+I+ +YDIK R+G G GIVWK +D+K+G+ VA+KKIFDAF+N+TDAQ RTFREI FLQ+F HPNII L NV +ADND+DIYLVF+ MD+DLH VI++GN+LK VHK YI YQ+LKA KYIHSGNVIHRD KPSNVLLD C VKLCDFGL RSL QI D DP LTEYVATRWYRAPEILL S +YTK VD+WSVGCI+ E++LGKA+F G+S+LNQIE+I+S +P+PS+ED+ +IKSEY S+L + + + + + P N A DL+K LL FNP KR T E+AL H Y+ +FH+P+ E+ +D+++V P++D+ +LS+ EYR+KLY+
Sbjct: 1 MNTDIDSHILLKYDIKKRLGKGELGIVWKGVDRKNGDVVAIKKIFDAFRNQTDAQQRTFREIIFLQEFGDHPNIINLRNVLRADNDKDIYLVFDFMDTDLHAVIRKGNILKDVHKAYITYQLLKATKYIHSGNVIHRDQKPSNVLLDGECFVKLCDFGLARSLKQIR--------------DEPGDPALTEYVATRWYRAPEILLASPRYTKGVDMWSVGCIVGEMLLGKAIFPGTSTLNQIERIMSVIPQPSKEDVLAIKSEYGGSVLEK-MGRQRQSLESLLP-NAPPNALDLLKRLLVFNPEKRLTAEEALGHPYVAQFHNPQTELAVDYDVV-PVDDDTRLSVAEYRNKLYE 339
BLAST of Mitogen-activated protein kinase vs. Ensembl Sea Lamprey
Match: mapk1 (mitogen-activated protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030722-2]) HSP 1 Score: 266.929 bits (681), Expect = 6.870e-84 Identity = 152/354 (42.94%), Postives = 217/354 (61.30%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKA 1121
RY + IG GAYG+V A D VA+KKI F+++T QRT REI L F H NII + ++ +A D +D+Y+V +LM++DL+ ++K G L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + LF G L+Q+ I+ L PS+ED++ I + R+ L + K +N +FP D A DL+ +L FNP +R TVE+AL H Y+E+++DP E + + P + +L D + +L +MI ++ A
Sbjct: 35 RYTSLSYIGEGAYGMVCAAFDNVKLVRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIIGINDILRASTIDQMKDVYIVQDLMETDLYKLLK-GQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPLFPGKHYLDQLNHILGILGSPSQEDLDCIINMKARNYLQSLPPKAKVPWNRLFP-KADSKALDLLDKMLTFNPHRRITVEEALAHPYLEQYYDPSDEPVAEE----PFRFDMELD-DLPKERLKEMIFEETA 363
BLAST of Mitogen-activated protein kinase vs. Ensembl Sea Lamprey
Match: mapk14a (mitogen-activated protein kinase 14a [Source:NCBI gene;Acc:65237]) HSP 1 Score: 224.942 bits (572), Expect = 5.369e-68 Identity = 119/333 (35.74%), Postives = 195/333 (58.56%), Query Frame = 3
Query: 42 NEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDR----DIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGS----SSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELE 1016
N+ + +RY +G GAYG V ++D K+G VA+KK+ F++ A+RT+RE+ L+ H N+I L++V ++ D+YLV +LM +DL+N++K L H ++++YQIL+ +KYIHS +IHRDLKPSN+ ++ +C +K+ DFGL R + D +T YVATRWYRAPEI+L Y ++VD+WSVGCI+AE++ G+ LF G+ S +NQ+ KI+ P + ++ ++S+ R+ + + Y + F ++F + + DL++ +L + +R T +AL H Y ++HDP+ E
Sbjct: 15 NKTVWEVPRRYVNLTSVGSGAYGSVCSSLDTKTGMKVAVKKLSRPFQSVIHAKRTYRELRLLKHMK-HENVIGLMDVFTPNSSLEEFDDLYLVTDLMGADLNNIVKCQKLTDD-HVQFLVYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLAR----------------------HADDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDRILSDINQLVKILQLTGTPPQYLIDRMQSKEARNYIQSLPYTQKRDFKDVF-LGANPLVVDLLERMLVLDTDQRITAAEALVHQYFAQYHDPDDE 322
BLAST of Mitogen-activated protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000729.1 (pep scaffold:Pmarinus_7.0:GL477416:20288:37329:-1 gene:ENSPMAG00000000656.1 transcript:ENSPMAT00000000729.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 218.779 bits (556), Expect = 5.088e-65 Identity = 135/366 (36.89%), Postives = 202/366 (55.19%), Query Frame = 3
Query: 60 IIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINV----RKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQV-----------AFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP-ELEI----IMDHEIVPPINDECQLSIDEYRSKLY 1097
++KRY IG GA GIV A D NVA+KK+ F+N+T A+R +RE+ ++ + H NII L NV + + +D+YLV ELMD++L VI+ L Y+IYQ+L +K++HS +IHRDLKPSN+++ S+CT+K+ DFGL R+ +T YV TR+YRAPE++LG YT++VD+WSVGC+L E++ + LF G ++Q KI+ L P E M+ ++ + N+ Y G F ++FP + A DL+ +L +P KR V+QAL H YI ++DP E+E I D ++ DE + SIDE++ +Y
Sbjct: 22 VLKRYQNLKPIGSGAQGIVCAAYDIMQNRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNIICLFNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME--LDHERMSYLIYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--------------------GNSFMMTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCVLGEMIRHRILFPGKDYIDQWNKIIEQLGTPMAEFMKKLQPTVRNYVENRPKYA-GYSFEKLFPDVLFPADSENNRLKASQARDLLSKMLVIDPAKRINVDQALAHPYINIWYDPSEVEAPPPKIYDKQL-----DEREHSIDEWKELIY 357
BLAST of Mitogen-activated protein kinase vs. Ensembl Yeast
Match: FUS3 (Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis [Source:SGD;Acc:S000000112]) HSP 1 Score: 259.61 bits (662), Expect = 1.565e-81 Identity = 140/341 (41.06%), Postives = 207/341 (60.70%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKAD---NDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRP-SEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPP 1046
M + NI + +K+ +G GAYG+V A K +GE VA+KKI + F A RT REI L+ F H NIIT+ N+++ D N ++Y++ ELM +DLH VI +L H +Y IYQ L+AVK +H NVIHRDLKPSN+L++SNC +K+CDFGL R + + + + + + G +TEYVATRWYRAPE++L S KY++++D+WS GCILAE+ L + +F G +Q+ I + P S+ D+ I+S R + + P ++FP V+ DL++ +L F+P KR T ++ALEH Y++ +HDP E + E +PP
Sbjct: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS-TQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG---------MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFP-RVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDE--PEGEPIPP 326
BLAST of Mitogen-activated protein kinase vs. Ensembl Yeast
Match: SLT2 (Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway [Source:SGD;Acc:S000001072]) HSP 1 Score: 258.84 bits (660), Expect = 1.377e-79 Identity = 136/332 (40.96%), Postives = 201/332 (60.54%), Query Frame = 3
Query: 30 FKMTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGEN--VALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLIN---VRKADND-RDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
FK+ N+ + ++ KR+ + IG GAYGIV A ++ E+ VA+KK+ + F +R+ RE+ L+ F GH NI L + V D +YL ELM+ D+H +IK G L H + YQIL +KYIHS +V+HRDLKP N+L++++C +K+CDFGL R S +P N + LTEYVATRWYRAPEI+L YTK++D+WS GCILAE + GK +F G +NQ+ +I+ L P +E + I S+ + ++Q+ + P F ++P N + A DL++ +L F+P+KR TV++ALEH Y+ +HDP
Sbjct: 10 FKVFNQ-DFSVDKRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIKSGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGY----SENPVENSQF-----------LTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETLRRIGSKNVQDYIHQLGFIPKVPFVNLYP-NANSQALDLLEQMLAFDPQKRITVDEALEHPYLSIWHDP 324
BLAST of Mitogen-activated protein kinase vs. Ensembl Yeast
Match: KSS1 (Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]) HSP 1 Score: 249.21 bits (635), Expect = 2.588e-77 Identity = 144/347 (41.50%), Postives = 200/347 (57.64%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLIN-VRKADNDR--DIYLVFELMDSDLHNVIKRGN----LLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFP-ANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPIN 1052
M + +I +Y + + IG GAYG V AI K SG VA+KKI F + RT REI L+ F H NII++++ VR D+ +YLV ELM++DL VI N L H +Y YQIL+A+K IHS VIHRD+KPSN+LL+SNC +K+CDFGL R L ++ + L F +TEYVATRWYRAPEI+L +YT ++D+WS GCILAE++ GK LF G +Q+ I+ L PS ED IKS+ + + + +P + ++ +++ DL+ +LQFNP KR + +AL H Y+ +HDP D PP+N
Sbjct: 1 MARTITFDIPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKI-QPFSKKLFVTRTIREIKLLRYFHEHENIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLAS-------SSDSRETLVGF-----MTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIKSKRAKEYIANLPMRPPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRISAAEALRHPYLAMYHDPS-----DEPEYPPLN 329
BLAST of Mitogen-activated protein kinase vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103]) HSP 1 Score: 234.187 bits (596), Expect = 6.955e-71 Identity = 133/349 (38.11%), Postives = 194/349 (55.59%), Query Frame = 3
Query: 60 IIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMI 1106
I RY+ N +G+GA+G+V A D + + VA+KKI F A+RT+RE+ L+ H N+I L ++ + + DIY V EL +DLH +++ L K +Y +YQIL+ +KY+HS VIHRDLKPSN+L++ NC +K+CDFGL R DP +T YV+TR+YRAPEI+L KY VD+WS GCI AE++ GK LF G ++Q I L P ++ + +I SE + + ++ F+E F V+ A DL++ +L F+P+KR T AL H Y +HDP E + D + ND L +D +R +Y I
Sbjct: 19 ITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLR-HENLICLQDIFLSPLE-DIYFVTELQGTDLHRLLQTRPLEKQF-VQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARI----------------------QDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERF-KTVEPDAVDLLEKMLVFDPKKRITAADALAHPYSAPYHDPTDEPVADAKFDWHFND-ADLPVDTWRVMMYSEI 340
BLAST of Mitogen-activated protein kinase vs. Ensembl Yeast
Match: KDX1 (Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication [Source:SGD;Acc:S000001644]) HSP 1 Score: 226.483 bits (576), Expect = 4.852e-68 Identity = 121/319 (37.93%), Postives = 187/319 (58.62%), Query Frame = 3
Query: 66 KRYDIKNRIGVGAYGIVWKAIDKKSGE--NVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITL----INVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHD 1004
K + + +IG G++ ++ + +S E +VA++KI +AF N+ +RT RE+ L+ GHPNI+ L I +YL ELM+ DL +I+ L+ H + IYQIL A+KYIHS NV+H DLKP N+L++S+C +K+C+FGL+ S + + +K DG + Y+ + WY+APEILL + TK+VD+WS GCILAE++ K +F G ++ + I+ L P EE ++ I S+ + + Q PG+ F I P + A +L+K +L+F+P+KR TVE ALEH Y+ +HD
Sbjct: 21 KHFHLTGKIGRGSHSLICSSTYTESNEETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHPNIVWLFDTDIVFYPNGALNGVYLYEELMECDLSQIIRSEQRLEDAHFQSFIYQILCALKYIHSANVLHCDLKPKNLLVNSDCQLKICNFGLSCS-------YSENHKVNDGF--------IKGYITSIWYKAPEILLNYQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPEETLQEIASQKVYNYIFQFGNIPGRSFESILPG-ANPEALELLKKMLEFDPKKRITVEDALEHPYLSMWHD 323
BLAST of Mitogen-activated protein kinase vs. Ensembl Nematostella
Match: EDO39421 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA30]) HSP 1 Score: 410.609 bits (1054), Expect = 2.924e-140 Identity = 197/331 (59.52%), Postives = 254/331 (76.74%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRW-YRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIF---PANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELE 1016
M+ +++S+I K+Y+IK R+G GAYGIVWKAID+++GE VA+KKIFDAF+N+TDAQRTFREI FLQ+F H N++ L+NV KADND+DIYLVFE MD+DLHNVIKRGN+LK +HK YI+YQ+LKA K+IHSGNVIHRDLKPSN+LLDS C K+CDFGL RS+ I T G DP+LT+YVATR RAPEILL S +YTK VD+WS+GCIL E++LGK LF GSS+LNQIEKI++++ PS +D++SIKS Y S+L+++ KP + ++ P++ A DL+ LLQFNP KR T E+AL H Y+ +FH+PE E
Sbjct: 1 MSADIDSHITKKYEIKKRLGKGAYGIVWKAIDRRTGEVVAVKKIFDAFRNQTDAQRTFREICFLQEFGDHENVVKLMNVIKADNDKDIYLVFEYMDTDLHNVIKRGNILKDIHKRYIMYQLLKATKFIHSGNVIHRDLKPSNLLLDSECFAKICDFGLARSVSNI----------TQEAG----DPSLTDYVATRGILRAPEILLASPRYTKGVDMWSIGCILGELLLGKPLFPGSSTLNQIEKIMTSIAPPSRQDVDSIKSHYSTSVLDRMACKPKRSLADVLNTAPSD----AIDLLNKLLQFNPDKRLTAEEALSHPYVARFHNPEEE 313
BLAST of Mitogen-activated protein kinase vs. Ensembl Nematostella
Match: EDO37435 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFQ0]) HSP 1 Score: 281.567 bits (719), Expect = 1.256e-89 Identity = 147/320 (45.94%), Postives = 210/320 (65.62%), Query Frame = 3
Query: 57 NIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINV---RKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
++ RY N IG GAYG+V +D +GE +A+KKI F+++T QRT REI L F H NII ++++ +A++ +DIY+V LM++D++ ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S Y+K++D+WSVGCILAE++ + LF G L+Q+ I++ L P +D+ IK+E RS L + YKP F ++F +N D A DL++NLL FNP KR TVE+AL H Y+E+++DP
Sbjct: 16 DVAPRYTNLNYIGEGAYGMVVAGVDNTTGERIAIKKI-SPFEHQTYCQRTLREIKILSRFK-HENIIGILDIIRAPRAEDMKDIYIVQPLMETDMYKLLKTQRL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARI----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCILAEMLANRPLFPGKHYLDQLNLILNVLGSPIADDLLCIKNEKARSYLQSLPYKPKTPFIKLF-SNADAKALDLIENLLAFNPNKRITVEEALAHPYLEQYYDP 315
BLAST of Mitogen-activated protein kinase vs. Ensembl Nematostella
Match: EDO40573 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6R5]) HSP 1 Score: 254.218 bits (648), Expect = 1.354e-78 Identity = 134/329 (40.73%), Postives = 204/329 (62.01%), Query Frame = 3
Query: 42 NEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA----DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELE 1016
E++ + RY + IG GAYG+V A+D ++G VA+KKI AF T A+RT RE+ L+ F H NII + ++ K D D+Y+V +LM+SDLH +I L + H Y +YQIL+ +KYIHS V+HRDLKPSN+L++ N +K+ DFG+ R L P K +TEYVATRWYRAPE++L +Y++++D+WSVGCILAE++ + LF G++ LNQ++ I+S PS+ +E + +E ++ LNQ+ +K F + FP + A +L+ +LQ +P++R TVE AL+H +++++H E E
Sbjct: 13 TEIKFVVDARYKLIETIGNGAYGVVCSAMDTRTGAKVAVKKISRAFDVLTTARRTHRELKILRHFK-HDNIICIRDILKPPVNLDEFDDVYVVLDLMESDLHRIIHTDQPLTTEHVRYFLYQILRGLKYIHSAKVLHRDLKPSNLLVNENAELKIGDFGMARGLCS----SPLEQKRF-----------MTEYVATRWYRAPELMLSLNEYSEAIDMWSVGCILAEMIGRRPLFPGANYLNQLQMILSVTGTPSQNFIERMGAERVKTYLNQLPHKDPVPFEKFFPKAHPE-AINLLSQMLQLDPKERITVENALQHPFLKEYHSEEDE 324
BLAST of Mitogen-activated protein kinase vs. Ensembl Nematostella
Match: EDO46881 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNM4]) HSP 1 Score: 221.09 bits (562), Expect = 3.533e-66 Identity = 131/363 (36.09%), Postives = 203/363 (55.92%), Query Frame = 3
Query: 60 IIKRYDIKNRIGVGAYGIVWKAI------DKKSGEN-VALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA----DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPIN---DECQLSIDEYRSKLYDMI 1106
+ ++Y + IG GAYG V + G N VA+KK+ F++ A+RT+RE+ L+ H N+I+L++V ++ +D+Y+V ELM SDL N I R L H ++++YQIL+ +KYIHS VIHRDLKPSN+ ++ +C +K+ DFGL R TD +T YVATRWYRAPEI+L Y ++VD+WSVGCI+AE++ K LF G+ ++Q+ KI+ + +PS++ ++ I SE R+ + Q+ F+E F + +A DL++ +L + R T +AL H Y+ + DP D + DE +LSI+ +R+ +Y I
Sbjct: 20 VPRKYQELSPIGTGAYGQVCSSTITEPDPTNPDGPNTVAIKKLSRPFQSTMHAKRTYRELKLLRHMR-HENVISLLDVFTTASAFEHFQDVYMVTELMGSDL-NGILRFQKLSDEHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELKILDFGLARM----------------------TDAEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTSKTLFPGNDHIDQLTKIMQLVGKPSDDFLQKIDSESARNYIAQMPDYRKTPFDEYF-VGANPLAVDLLEKMLNLDTDHRITAVEALSHPYLASYADPN-----DEPTCSTFDDSFDEKELSIEGWRALVYQEI 352
BLAST of Mitogen-activated protein kinase vs. Ensembl Nematostella
Match: EDO30527 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0K0]) HSP 1 Score: 209.534 bits (532), Expect = 2.954e-61 Identity = 118/313 (37.70%), Postives = 179/313 (57.19%), Query Frame = 3
Query: 90 IGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDM-ESIKSEYCRSILNQIIYKPGKKFNEIFPAN-VDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIE----KFH 1001
IG GA+G+VW D ++G+ VALKK+ F+N T ++R +RE+ L H N+I+ I++ D +IY+V ELM SDLH +I L + H + +YQIL+ +KY+ S ++HRD+KP N+L++SNC +K+CDFGL R ES+ +T+ V T++YR+PE+L GST YT++VD+WSVGCI AE++ K LF S + Q+ +I+ L P ED+ ++ SE + Q +KP + +N A L+ +L FNP KR + AL H Y++ +FH
Sbjct: 45 IGYGAFGVVWSVTDPRNGKRVALKKMPKVFQNITSSRRAYRELRMLCTLK-HDNVISAIDIVHPGHIDLFHEIYVVSELMQSDLHKIIVSPQPLTADHVKVFLYQILRGLKYLDSAKILHRDIKPGNLLVNSNCLLKICDFGLARLEEPDESV------------------IMTQEVVTQYYRSPELLTGSTHYTQAVDIWSVGCIFAELLSRKILFQAQSPVQQLNQIIDLLGTPCLEDLSKAGSSEGATKYILQRPHKPPALASLYNLSNQATHEAVHLLCRMLVFNPNKRISCIDALSHPYLDEGRLRFH 338
BLAST of Mitogen-activated protein kinase vs. Ensembl Medaka
Match: mapk15 (mitogen-activated protein kinase 15 [Source:NCBI gene;Acc:101164415]) HSP 1 Score: 466.463 bits (1199), Expect = 2.133e-157 Identity = 211/362 (58.29%), Postives = 287/362 (79.28%), Query Frame = 3
Query: 39 TNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAE 1124
+E+E +I +YDIK R+G GAYGIVWK +D+K+GE VA+KKIFDAF+N TDAQRTFREI FLQ+F HPNI+ LINV +A+ND+DIYL+FE MD+DLH VIK+G+LLK +HK Y++YQ+ KA+KY+HSGNVIHRD KPSNVLLD++C VKLCDFGL RSL+Q++ + + +P LTEYVATRWYRAPEILLGST+YTK VD+WS+GC+L E++LGKALF G+S++NQIEKI+SA+P PS +DM +IKSEY S++ +++ KP ++ P +V A +LVK+LL FNP KR T EQAL+H Y+ +FH+P E +++++V P++D+ QLS+ +YR+KLY+M+ + K++
Sbjct: 10 VSEMEEHIFHKYDIKKRLGKGAYGIVWKGVDRKTGETVAVKKIFDAFRNSTDAQRTFREIMFLQEFGDHPNIVKLINVLRAENDKDIYLIFEYMDTDLHTVIKKGSLLKDIHKRYVMYQLFKAIKYLHSGNVIHRDQKPSNVLLDTDCVVKLCDFGLARSLNQVQ--------------EDSVNPALTEYVATRWYRAPEILLGSTRYTKGVDMWSLGCVLGEMLLGKALFPGTSTINQIEKIMSAIPHPSPDDMFAIKSEYGSSVIQRMLLKPQVPLEDLLPPSVPHDALNLVKSLLVFNPEKRLTAEQALQHPYVARFHNPAKEPSLNYDVVLPVDDDVQLSVVQYRNKLYEMMLEWKSK 357
BLAST of Mitogen-activated protein kinase vs. Ensembl Medaka
Match: mapk15 (mitogen-activated protein kinase 15 [Source:NCBI gene;Acc:101164415]) HSP 1 Score: 466.463 bits (1199), Expect = 2.133e-157 Identity = 211/362 (58.29%), Postives = 287/362 (79.28%), Query Frame = 3
Query: 39 TNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAE 1124
+E+E +I +YDIK R+G GAYGIVWK +D+K+GE VA+KKIFDAF+N TDAQRTFREI FLQ+F HPNI+ LINV +A+ND+DIYL+FE MD+DLH VIK+G+LLK +HK Y++YQ+ KA+KY+HSGNVIHRD KPSNVLLD++C VKLCDFGL RSL+Q++ + + +P LTEYVATRWYRAPEILLGST+YTK VD+WS+GC+L E++LGKALF G+S++NQIEKI+SA+P PS +DM +IKSEY S++ +++ KP ++ P +V A +LVK+LL FNP KR T EQAL+H Y+ +FH+P E +++++V P++D+ QLS+ +YR+KLY+M+ + K++
Sbjct: 10 VSEMEEHIFHKYDIKKRLGKGAYGIVWKGVDRKTGETVAVKKIFDAFRNSTDAQRTFREIMFLQEFGDHPNIVKLINVLRAENDKDIYLIFEYMDTDLHTVIKKGSLLKDIHKRYVMYQLFKAIKYLHSGNVIHRDQKPSNVLLDTDCVVKLCDFGLARSLNQVQ--------------EDSVNPALTEYVATRWYRAPEILLGSTRYTKGVDMWSLGCVLGEMLLGKALFPGTSTINQIEKIMSAIPHPSPDDMFAIKSEYGSSVIQRMLLKPQVPLEDLLPPSVPHDALNLVKSLLVFNPEKRLTAEQALQHPYVARFHNPAKEPSLNYDVVLPVDDDVQLSVVQYRNKLYEMMLEWKSK 357
BLAST of Mitogen-activated protein kinase vs. Ensembl Medaka
Match: mapk3 (mitogen-activated protein kinase 1 [Source:NCBI gene;Acc:101159747]) HSP 1 Score: 265.774 bits (678), Expect = 1.801e-82 Identity = 144/316 (45.57%), Postives = 199/316 (62.97%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITL---INVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY + IG GAYG+V A+D + + VA+KKI F+++T QRT REI L F+ H NII + + R DN RD+Y+V LM++DL+ ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+L+++ C +K+CDFGL R A+ E D G LTEYVATRWYRAPEI+L S Y+KS+D+WSVGCILAE++ K +F G L+Q+ I+ L PS+ED+ SI + R+ L + KP ++F D A DL+ +L FNP KR +VE AL H Y+E+++DP
Sbjct: 52 RYTNLSYIGEGAYGMVCSALDNLTNQRVAIKKI-SPFEHQTYCQRTLREIKILLRFN-HENIIGINDILRARHIDNMRDVYIVQTLMETDLYKLLK-SQRLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI----------ADPEHDHTG------FLTEYVATRWYRAPEIMLNSKGYSKSIDIWSVGCILAEMLSNKPIFPGKHYLDQLNHILGVLGSPSQEDLNSIINVKARNYLQSLPEKPKVPLEKLF-VKADPKALDLLGRMLTFNPVKRISVEDALAHPYLEQYYDP 347
BLAST of Mitogen-activated protein kinase vs. Ensembl Medaka
Match: mapk1 (mitogen-activated protein kinase 1 [Source:NCBI gene;Acc:101162905]) HSP 1 Score: 259.61 bits (662), Expect = 1.865e-80 Identity = 142/316 (44.94%), Postives = 201/316 (63.61%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKA---DNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY + IG GAYG+V A D+ + VA+KKI F+++T QRT REI L F H NII + ++ +A + +D+Y+V +LM++DL+ ++K +L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ + D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ + +F G L+Q+ I+ L PS+ED+ I + R+ L + + +N +FP N D A DL+ +L FNP KR VEQAL H Y+E+++DP
Sbjct: 33 RYSNLSYIGEGAYGMVCSAYDRDNKIRVAIKKI-SPFEHQTYCQRTLREIKILLRFK-HENIIGINDIIRAPSIEQMKDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPDHDHTG------FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARNYLLSLPLRCKVPWNRLFP-NADPKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 328
BLAST of Mitogen-activated protein kinase vs. Ensembl Medaka
Match: mapk7 (mitogen-activated protein kinase 7 [Source:NCBI gene;Acc:101157651]) HSP 1 Score: 271.552 bits (693), Expect = 9.134e-79 Identity = 135/330 (40.91%), Postives = 208/330 (63.03%), Query Frame = 3
Query: 45 EVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADND----RDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEII 1022
+V+ ++ + YDI IG GAYG+V A + +G+ VA+KKI +AF+ T+A+RT RE+ L+ F H NII + ++ + + + +Y+V +LM+SDLH +I L H Y +YQ+L+ +KY+HS NVIHRDLKPSN+L++ NC +K+ DFG+ R L S HP+ + +TEYVATRWYRAPE+LL Y+ ++DLWSVGCI AE++ K LF G ++Q++ I+S L P E + +I++E RS + + + ++++P + A DL+ +L+F+PR+R V +ALEH Y+ K+HDP+ E I
Sbjct: 56 DVKFDVGEEYDIIETIGTGAYGVVSSARRRDNGQQVAIKKISNAFEVVTNAKRTLRELKILKHFK-HDNIIAIKDILQPNLPHSAFKSVYVVLDLMESDLHQIIHSTQTLTPEHTRYFLYQLLRGLKYVHSANVIHRDLKPSNLLVNENCELKIGDFGMARGL----SSHPEESYS-----------FMTEYVATRWYRAPELLLSLNHYSLAIDLWSVGCIFAEMLGRKQLFPGKHYVHQLQLILSVLGTPPEGLISAIRAERVRSYVQSLPSRTAVPLSKLYP-QAEPDALDLLGAMLRFDPRQRIGVTEALEHPYLAKYHDPDDEPI 368
BLAST of Mitogen-activated protein kinase vs. Planmine SMEST
Match: SMESG000081061.1 (SMESG000081061.1) HSP 1 Score: 1190.25 bits (3078), Expect = 0.000e+0 Identity = 583/584 (99.83%), Postives = 584/584 (100.00%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEEIKSLRXXXXXXXXXXXENAMIMEQKIASRANYDIAFGRTTHQRPPPPKNNHASNQSNNPLIGMKAFLTKTENTKIDNSRSRLSHSAFQRDDGNSRNETSFQKKSFGSDVEQKRPSRNVMTCSKEASNPVILRDLHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQFDNAKNHSNMRSTLGSYSQTYGTVSSSQLNNLYSRNCVR 1787
MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEEIKSLRSTDNTDDNNSSENAMIMEQKIASRANYDIAFGRTTHQRPPPPKNNHASNQSNNPLIGMKAFLTKTENTKIDNSRSRLSHSAFQRDDGNSRNETSFQKKSFGSDVEQKRP+RNVMTCSKEASNPVILRDLHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQFDNAKNHSNMRSTLGSYSQTYGTVSSSQLNNLYSRNCVR
Sbjct: 1 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQARRPNEEIKSLRSTDNTDDNNSSENAMIMEQKIASRANYDIAFGRTTHQRPPPPKNNHASNQSNNPLIGMKAFLTKTENTKIDNSRSRLSHSAFQRDDGNSRNETSFQKKSFGSDVEQKRPNRNVMTCSKEASNPVILRDLHSTSISATGNKVSMQSRPASAQHVRSNSATFGRKQFDNAKNHSNMRSTLGSYSQTYGTVSSSQLNNLYSRNCVR 584
BLAST of Mitogen-activated protein kinase vs. Planmine SMEST
Match: SMESG000033376.1 (SMESG000033376.1) HSP 1 Score: 496.893 bits (1278), Expect = 3.358e-167 Identity = 227/370 (61.35%), Postives = 294/370 (79.46%), Query Frame = 3
Query: 36 MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDPELEIIMDHEIVPPINDECQLSIDEYRSKLYDMITQKKAEKEARTQA 1145
MTNEVES+I+++Y+IK R+G GAYGIVWK IDKKS E VALKKIFDAF+N+TDAQRTFREIAFL+ F GHPNII L NV KA+ND+DIYL FE M++DLHNVIKRGN+LK VHK+YI+YQ+LKA KY+HS NVIHRD KPSNVLLDS+C VKLCDFGL RSL + ++++P N P LTEYVATRWYRAPEIL+ S KYTK VD+WS+GCIL E++LGKALF G S++NQI+ I++ +P+P +ED+E++ Y +++ ++ +P + N++ P N D VA DL+ LLQFNP KR T+E+ALEH Y+++FH+ E+ M HE++PP++D+ QLS++EYRSKLY I Q KA+K+AR +A
Sbjct: 1 MTNEVESHILEKYEIKKRLGKGAYGIVWKVIDKKSQEVVALKKIFDAFRNKTDAQRTFREIAFLKQFHGHPNIIKLYNVLKAENDKDIYLTFEFMETDLHNVIKRGNILKDVHKQYIMYQLLKATKYLHSANVIHRDQKPSNVLLDSDCFVKLCDFGLARSLSERDTMNPNPNL-----------PPLTEYVATRWYRAPEILMASHKYTKGVDMWSLGCILGEMILGKALFPGKSTMNQIDLIMTYIPKPEKEDIETMLKVYGATMVTKVNTRPRRTLNDLIP-NSDSVAMDLIIKLLQFNPDKRNTIEEALEHPYVKRFHNVAEELSMGHEVIPPVDDDIQLSVEEYRSKLYKFIMQNKAQKKARKRA 358
BLAST of Mitogen-activated protein kinase vs. Planmine SMEST
Match: SMESG000001435.1 (SMESG000001435.1) HSP 1 Score: 267.314 bits (682), Expect = 5.494e-84 Identity = 153/335 (45.67%), Postives = 207/335 (61.79%), Query Frame = 3
Query: 36 MTNEVESNIIK--------RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINVRKADN---DRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
MT+EVE +IK RY N IG GAYG+V A D E VA+KKI F+ +T QRT REI L F H NII + ++ A++ +D+Y+V LM++DL ++K L + H Y +YQIL+ +KYIHS NV+HRDLKPSN+LL++ C +K+CDFGL R A+ E D G LTEYVATRWYRAPEI+L S YTKS+D+WSVGCILAE++ K LF G ++Q+ I+ L P++ED++SI + R L Q+ YKP + ++P N D A DL++ LL FNP R VE AL H Y+++++DP
Sbjct: 1 MTDEVE--VIKGQAFEVKPRYIDLNYIGEGAYGMVASAYDNIKKEKVAIKKI-SPFEYQTYCQRTLREIKILTRFK-HENIIDIRDIITANSINEMKDVYIVQCLMETDLFKLLKTQQL-SNDHTCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------ADPEHDHTG------LLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLNNKPLFPGKHYIDQLNLILGVLGSPNQEDLDSIVNLKARGYLQQLPYKPKVSWKSLYP-NADDQALDLIEKLLTFNPVNRIGVEDALAHPYLKQYYDP 313
BLAST of Mitogen-activated protein kinase vs. Planmine SMEST
Match: SMESG000032743.1 (SMESG000032743.1) HSP 1 Score: 259.225 bits (661), Expect = 1.268e-80 Identity = 143/323 (44.27%), Postives = 199/323 (61.61%), Query Frame = 3
Query: 48 VESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNII---TLINVRKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
VE ++ RY IG GAYG V AID K NVA+K+ F+++T QRT+REI L F+ H NII L+ ++ +D+Y+V LM++DLH + K L H Y +YQIL+ +KYIHS NVIHRDLKPSN+L++SNC +K+CDFGL+R + E D G LTEYVATRWYRAPEI+L S YTK++D+WSVGCILAE++ GK +F G + Q+ I++ L P EED I +E R + + + K + +++P N D+ +++ LL FNP KR TVEQAL Y+ ++++P
Sbjct: 13 VEFDVGPRYGNFKFIGEGAYGQVVSAIDTKDNSNVAIKRT-SPFEHQTYCQRTYREIKILMHFN-HENIIDIRNLLTAKEMIEMKDLYIVQALMETDLHKLCKSQKL-SLEHICYFLYQILRGLKYIHSANVIHRDLKPSNLLVNSNCDLKICDFGLSRV----------NDPEHDHKG------ILTEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLNGKPIFPGKHYVEQLTLIITVLGYPCEEDKAWIVNEKARHFVEKFVTKMKTPWKQLYP-NADEQCITMLEGLLTFNPGKRLTVEQALAMPYLNQYYEP 315
BLAST of Mitogen-activated protein kinase vs. Planmine SMEST
Match: SMESG000012868.1 (SMESG000012868.1) HSP 1 Score: 258.84 bits (660), Expect = 1.740e-80 Identity = 139/317 (43.85%), Postives = 200/317 (63.09%), Query Frame = 3
Query: 69 RYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNETDAQRTFREIAFLQDFSGHPNIITLINV----RKADNDRDIYLVFELMDSDLHNVIKRGNLLKSVHKEYIIYQILKAVKYIHSGNVIHRDLKPSNVLLDSNCTVKLCDFGLTRSLHQIESLHPKANKETDGLGDFNTDPTLTEYVATRWYRAPEILLGSTKYTKSVDLWSVGCILAEIMLGKALFTGSSSLNQIEKIVSALPRPSEEDMESIKSEYCRSILNQIIYKPGKKFNEIFPANVDQVAFDLVKNLLQFNPRKRFTVEQALEHAYIEKFHDP 1007
RY IG GAYGIV A D + E+VA+K+I F+++T QRT+REI L F H N+I + N+ K ++ +DIY+V LMD+D++ +IK L + H Y +YQIL+ VKYIHS NV+HRDLKPSN+L++SNC +K+CDFGL R D + D N LTEYVATRWYRAPE++L S Y+K++D+WS+GCILAE++ K LF G + Q++ I L P ED I +E R+ + ++I P + + E+FP N + D++ LL FNP KR T ++AL+H Y++++++P
Sbjct: 20 RYTNLRFIGEGAYGIVVSATDNVTHEDVAIKRI-SPFEHQTFCQRTYREIKILLHFK-HENVIDIKNLLTPASKIEDIKDIYIVQSLMDTDMYKLIKDQKL-SNEHICYFLYQILRGVKYIHSANVLHRDLKPSNLLVNSNCDLKICDFGLARV--------------NDPVQDHNG--MLTEYVATRWYRAPEVMLNSKGYSKAMDMWSIGCILAEMLGCKPLFPGKHYVQQLKLIFDVLGSPDYEDKSWIVNEKARNFVEKLIDIPKRPWEELFP-NSEPFCLDILDQLLAFNPSKRLTADKALQHPYLQQYYEP 316 The following BLAST results are available for this feature:
BLAST of Mitogen-activated protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Mitogen-activated protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30008112 ID=SMED30008112|Name=Mitogen-activated protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1906bpback to top protein sequence of SMED30008112-orf-1 >SMED30008112-orf-1 ID=SMED30008112-orf-1|Name=SMED30008112-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=585bp MTNEVESNIIKRYDIKNRIGVGAYGIVWKAIDKKSGENVALKKIFDAFKNback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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