Serine/threonine-protein kinase PLK

Overview
NameSerine/threonine-protein kinase PLK
Smed IDSMED30008091
Length (bp)863
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Serine/threonine-protein kinase PLK (SMED30008091) t-SNE clustered cells

Violin plots show distribution of expression levels for Serine/threonine-protein kinase PLK (SMED30008091) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Serine/threonine-protein kinase PLK (SMED30008091) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Serine/threonine-protein kinase PLK (SMED30008091) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30008091

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 15

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30008091h1SMcG0014899 Contig809GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
gutSMED30008091h1SMcG0014899 Contig809GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30008091h1SMcG0014899 Contig809GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
pharynxSMED30008091h1SMcG0014899 Contig2364GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
gutSMED30008091h1SMcG0014899 Contig2364GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30008091h1SMcG0014899 Contig2364GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30008091h1SMcG0014899 PL08004B1B07smed_ncbi_20240424PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30008091h1SMcG0014899 PL08004B1B07ncbi_smed_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
head regionSMED30008091h1SMcG0014899 SmedASXL_032732SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
pharynxSMED30008091h1SMcG0014899 dd_Smed_v4_1620_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30008091h1SMcG0014899 dd_Smed_v4_1620_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30008091h1SMcG0014899 dd_Smed_v4_1620_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30008091h1SMcG0014899 dd_Smed_v4_1620_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30008091h1SMcG0014899 dd_Smed_v4_1620_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30008091h1SMcG0014899 dd_Smed_v4_1620_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PLK4 (polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397])

HSP 1 Score: 125.176 bits (313), Expect = 1.354e-31
Identity = 85/264 (32.20%), Postives = 135/264 (51.14%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVI---YNYRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM--SIRASDIYSAPEINDYGEANFNSDVWSLGRTV-CYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +I+ L +YF  +  V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +N+L T   R +  KI+DFG++  +    +   ++  +  Y +PEI         SDVWSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++  +S
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT---RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSS 270
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PLK4 (polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397])

HSP 1 Score: 125.176 bits (313), Expect = 1.398e-31
Identity = 85/264 (32.20%), Postives = 135/264 (51.14%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVI---YNYRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM--SIRASDIYSAPEINDYGEANFNSDVWSLGRTV-CYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +I+ L +YF  +  V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +N+L T   R +  KI+DFG++  +    +   ++  +  Y +PEI         SDVWSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++  +S
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT---RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSS 270
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PLK4 (polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397])

HSP 1 Score: 125.176 bits (313), Expect = 1.504e-31
Identity = 85/264 (32.20%), Postives = 135/264 (51.14%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYN---YRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM--SIRASDIYSAPEINDYGEANFNSDVWSLGRTV-CYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +I+ L +YF  +  V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +N+L T   R +  KI+DFG++  +    +   ++  +  Y +PEI         SDVWSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++  +S
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT---RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSS 270
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PLK3 (polo like kinase 3 [Source:HGNC Symbol;Acc:HGNC:2154])

HSP 1 Score: 117.857 bits (294), Expect = 3.852e-29
Identity = 79/255 (30.98%), Postives = 119/255 (46.67%), Query Frame = 1 
Query:  124 KKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE--KMSIRASDIYSAPEINDYGEANFNSDVWSLG----RTVCYMITRDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            K   LG+GGF   Y   + +  +  AVKVI   R+++ +QR     EI+  + L  R+IVR   +F    N+ + +ELC     + I        EPE+R ++RQ  +GL+Y+H  GILHRD+K  N   T     +  K+ DFG++  ++  E  K +I  +  Y APE+         +DVWSLG      +C     +  DL   +             +S     LL  +L   P DR   D++L H F T
Sbjct:   64 KGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT---ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFT 315
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PLK4 (polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397])

HSP 1 Score: 115.931 bits (289), Expect = 2.498e-28
Identity = 79/257 (30.74%), Postives = 122/257 (47.47%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM--SIRASDIYSAPEINDYGEANFNSDVWSLGRTV-CYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            F   N LG+G F  VYR E++     VA+K++YNY                           F  +  V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +N+L T   R +  KI+DFG++  +    +   ++  +  Y +PEI         SDVWSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++  +S
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMLYNY---------------------------FEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT---RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSS 238
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: rskn-2 (Putative ribosomal protein S6 kinase alpha-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18846])

HSP 1 Score: 111.694 bits (278), Expect = 2.442e-27
Identity = 82/285 (28.77%), Postives = 138/285 (48.42%), Query Frame = 1 
Query:   91 SMTTIGYYYFNKKN--FLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTE--IDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDI---YSAPEINDYG----EANFNSDVWSLGRTVCYM------------------ITRDINDLDNYF-------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLN 834
            S +    Y  +K +   LG+G F +V R E V D    AVK++     SQ QR    ++ ++G    NIV+L D  +   +  L+ME+  G ++  RI+ + R F+E E  + +RQ  + ++Y+H+  I+HRD+KP NILF         ++ DFG ++++  + +  ++       Y+APE+ D G    E N   D+WSLG  +  M                  I + I   +  F       VS+D  +L+ G+L  DP  RL   E+ +H ++    S++
Sbjct:  371 SSSFFAKYKLDKSDAGLLGKGAFSVVRRCERVVDGAQFAVKIVSQKFASQAQREARILEMVQG--HPNIVQLHDVHSDPLHFYLVMEILTGNELLERIRKLER-FTESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESIDSSARLRLVDFGFARLLPNSMEQQLKTPCFTLQYAAPEVLDVGDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSMQELTAHMWLKSSASMD 652
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: rskn-2 (Putative ribosomal protein S6 kinase alpha-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18846])

HSP 1 Score: 110.923 bits (276), Expect = 4.504e-27
Identity = 82/293 (27.99%), Postives = 140/293 (47.78%), Query Frame = 1 
Query:   91 SMTTIGYYYFNKKN--FLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTE--IDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDI-----------YSAPEINDYG----EANFNSDVWSLGRTVCYM------------------ITRDINDLDNYF-------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLN 834
            S +    Y  +K +   LG+G F +V R E V D    AVK++     SQ QR    ++ ++G    NIV+L D  +   +  L+ME+  G ++  RI+ + R F+E E  + +RQ  + ++Y+H+  I+HRD+KP NILF         ++ DFG ++++  + +  +++  +           Y+APE+ D G    E N   D+WSLG  +  M                  I + I   +  F       VS+D  +L+ G+L  DP  RL   E+ +H ++    S++
Sbjct:  371 SSSFFAKYKLDKSDAGLLGKGAFSVVRRCERVVDGAQFAVKIVSQKFASQAQREARILEMVQG--HPNIVQLHDVHSDPLHFYLVMEILTGNELLERIRKLER-FTESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESIDSSARLRLVDFGFARLLPNSMEQQLKSVQVLRKMTPCFTLQYAAPEVLDVGDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSMQELTAHMWLKSSASMD 660
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: rskn-2 (Putative ribosomal protein S6 kinase alpha-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18846])

HSP 1 Score: 110.538 bits (275), Expect = 5.098e-27
Identity = 82/293 (27.99%), Postives = 140/293 (47.78%), Query Frame = 1 
Query:   91 SMTTIGYYYFNKKN--FLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTE--IDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDI-----------YSAPEINDYG----EANFNSDVWSLGRTVCYM------------------ITRDINDLDNYF-------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLN 834
            S +    Y  +K +   LG+G F +V R E V D    AVK++     SQ QR    ++ ++G    NIV+L D  +   +  L+ME+  G ++  RI+ + R F+E E  + +RQ  + ++Y+H+  I+HRD+KP NILF         ++ DFG ++++  + +  +++  +           Y+APE+ D G    E N   D+WSLG  +  M                  I + I   +  F       VS+D  +L+ G+L  DP  RL   E+ +H ++    S++
Sbjct:  371 SSSFFAKYKLDKSDAGLLGKGAFSVVRRCERVVDGAQFAVKIVSQKFASQAQREARILEMVQG--HPNIVQLHDVHSDPLHFYLVMEILTGNELLERIRKLER-FTESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESIDSSARLRLVDFGFARLLPNSMEQQLKSVQVLRKMTPCFTLQYAAPEVLDVGDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSMQELTAHMWLKSSASMD 660
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: plk-1 (Serine/threonine-protein kinase plk-1 [Source:UniProtKB/Swiss-Prot;Acc:P34331])

HSP 1 Score: 110.153 bits (274), Expect = 6.676e-27
Identity = 78/252 (30.95%), Postives = 125/252 (49.60%), Query Frame = 1 
Query:  115 YFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRL-SQYQRTEIDNLKGLNCR-----NIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE-KMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMI--------TRDINDL------DNYFVSS----DLYDLLNGMLEEDPDDRLEADEV 795
            Y+ K  FLG+GGF   Y   N   R  VA KV+    L  QYQR ++DN + L  R     NIV+L ++F    NV + +ELC       +    +  +EPE R F  Q   G+ Y+H+  I+HRD+K  N+     +  LV KI DFG++  ++G E K ++  +  Y APE+ +    +F  D+W++G  + Y++        ++ + +       +NY + S        L+  ML+ +P  R  A +V
Sbjct:   37 YYEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKVDNERILIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLMELHKRRKAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFL---NDDLVVKIGDFGLATTVNGDERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVG-CILYILLFGQPPFESKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQV 284
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: plk-1 (Serine/threonine-protein kinase plk-1 [Source:UniProtKB/Swiss-Prot;Acc:P34331])

HSP 1 Score: 105.531 bits (262), Expect = 2.466e-25
Identity = 76/251 (30.28%), Postives = 122/251 (48.61%), Query Frame = 1 
Query:  115 YFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRL-SQYQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE-KMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMI--------TRDINDL------DNYFVSS----DLYDLLNGMLEEDPDDRLEADEV 795
            Y+ K  FLG+GGF   Y   N   R  VA KV+    L  QYQR     E+   + L   NIV+L ++F    NV + +ELC       +    +  +EPE R F  Q   G+ Y+H+  I+HRD+K  N+     +  LV KI DFG++  ++G E K ++  +  Y APE+ +    +F  D+W++G  + Y++        ++ + +       +NY + S        L+  ML+ +P  R  A +V
Sbjct:   37 YYEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLMELHKRRKAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFL---NDDLVVKIGDFGLATTVNGDERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVG-CILYILLFGQPPFESKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQV 283
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: Aduk (gene:FBgn0037679 transcript:FBtr0082056)

HSP 1 Score: 112.464 bits (280), Expect = 5.497e-28
Identity = 71/251 (28.29%), Postives = 120/251 (47.81%), Query Frame = 1 
Query:  136 LGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID-GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG---------------RTVCYMITR-----DINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 813
            LG G +  VY+  + + RT  A+K +    LSQ  R    TEI  L+ L  + IV L D+F    N+ +++E C     S      +   E   R F+RQ A  ++Y+  N + H D+KP N+L T  +  +  K++DFG ++ +  G     ++ S +Y APEI    + +  +D+WS+G               RT+  ++ R      I    N  +S++ +DLL  +L  +P  R+   +  +H F+
Sbjct:   15 LGAGSYATVYKARHKKQRTYHAIKYVEMSTLSQTSRENLITEIRLLRELKHKYIVTLQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLTRGANNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSIGVILYECLFGKAPYSSRTIEELLLRIRKAEAITLPPNARISNECHDLLRRLLAHEPTARISFADFFAHPFL 265
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: Aduk (gene:FBgn0037679 transcript:FBtr0082055)

HSP 1 Score: 112.464 bits (280), Expect = 8.701e-28
Identity = 71/251 (28.29%), Postives = 120/251 (47.81%), Query Frame = 1 
Query:  136 LGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID-GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG---------------RTVCYMITR-----DINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 813
            LG G +  VY+  + + RT  A+K +    LSQ  R    TEI  L+ L  + IV L D+F    N+ +++E C     S      +   E   R F+RQ A  ++Y+  N + H D+KP N+L T  +  +  K++DFG ++ +  G     ++ S +Y APEI    + +  +D+WS+G               RT+  ++ R      I    N  +S++ +DLL  +L  +P  R+   +  +H F+
Sbjct:   15 LGAGSYATVYKARHKKQRTYHAIKYVEMSTLSQTSRENLITEIRLLRELKHKYIVTLQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLTRGANNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSIGVILYECLFGKAPYSSRTIEELLLRIRKAEAITLPPNARISNECHDLLRRLLAHEPTARISFADFFAHPFL 265
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: Atg1 (gene:FBgn0260945 transcript:FBtr0075945)

HSP 1 Score: 108.997 bits (271), Expect = 2.374e-26
Identity = 71/229 (31.00%), Postives = 115/229 (50.22%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQR---TEIDNLKGL---NCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTH-------KSRKLVYKISDFGISKMI-DGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT-------RDINDLDNYF 717
            M  +G Y ++ K+ LG G F +VY+G + +    VA+K I      + Q     EI  LK L   +  N+V LLD       V L+ME C G   +   ++    SE  +R F+ Q A  ++ ++  GI+HRD+KP NIL +H          K+  KI+DFG ++ + +G    ++  S +Y APE+    + +  +D+WSLG  V   +T       +  N+L +Y+
Sbjct:    1 MNIVGEYEYSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYY 229
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: Atg1 (gene:FBgn0260945 transcript:FBtr0300561)

HSP 1 Score: 108.997 bits (271), Expect = 2.758e-26
Identity = 71/229 (31.00%), Postives = 115/229 (50.22%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQR---TEIDNLKGL---NCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTH-------KSRKLVYKISDFGISKMI-DGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT-------RDINDLDNYF 717
            M  +G Y ++ K+ LG G F +VY+G + +    VA+K I      + Q     EI  LK L   +  N+V LLD       V L+ME C G   +   ++    SE  +R F+ Q A  ++ ++  GI+HRD+KP NIL +H          K+  KI+DFG ++ + +G    ++  S +Y APE+    + +  +D+WSLG  V   +T       +  N+L +Y+
Sbjct:    1 MNIVGEYEYSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYY 229
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: SAK (gene:FBgn0026371 transcript:FBtr0078387)

HSP 1 Score: 106.686 bits (265), Expect = 1.593e-25
Identity = 72/275 (26.18%), Postives = 137/275 (49.82%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVK-----VIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEK--MSIRASDIYSAPEINDYGEANFNSDVWSLGRTV-CYMITRDINDLD------------NYFVSSDL----YDLLNGMLEEDPDDRLEADEVLSHCFI--------TGQNSLNFFN 843
            +  ++ LG+GGF  VY+   +    +VA+K     +I    L+   R E++    L   ++++L  +F     V L++EL   G++   + +I R F+E E  + ++Q   GL Y+H++ I+HRDI  +N+L    SR++  KI+DFG++  +   ++  M++  +  Y +PE+         +DVWS+G  +   ++ R   + D             Y + + L     DL+N +L++ P +R+  + VL H F+        +   +LN F+
Sbjct:   14 YEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLL---SREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGHSAPGALNVFS 285
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: ulk1a (unc-51 like autophagy activating kinase 1a [Source:ZFIN;Acc:ZDB-GENE-080723-31])

HSP 1 Score: 118.627 bits (296), Expect = 1.981e-31
Identity = 75/210 (35.71%), Postives = 117/210 (55.71%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRT-NVAVKVIYNYRLSQYQR---TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKS-RK-----LVYKISDFGISKMIDG-TEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT 687
            M +IG Y FN+K+ +G G F +V++G + Q     VAVK I    L++ Q     EI  LK L   NIV LLD+  I+G V L+ME C G D+   + + G   SE  IR  ++Q A  +  + + GI+HRD+KP NIL ++ + RK     +  K++DFG ++ + G T   ++  S +Y APE+      +  +D+WS+G  +   +T
Sbjct:    1 MESIGKYEFNRKDLIGHGAFAVVFKGRHKQKHNFEVAVKCINRKNLAKSQSLLGKEIKILKELKHENIVSLLDFQEISGCVYLVMEYCNGGDLAEYLHSKG-CLSEDTIRVLLQQLAGAMSVLRSKGIIHRDLKPQNILLSYSTGRKSNPNNICIKLADFGFARYLQGNTMAATLCGSPMYMAPEVIMSHNYDAKADLWSVGTIIYQCLT 209
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: ulk1a (unc-51 like autophagy activating kinase 1a [Source:ZFIN;Acc:ZDB-GENE-080723-31])

HSP 1 Score: 119.398 bits (298), Expect = 1.126e-29
Identity = 75/210 (35.71%), Postives = 117/210 (55.71%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRT-NVAVKVIYNYRLSQYQR---TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKS-RK-----LVYKISDFGISKMIDG-TEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT 687
            M +IG Y FN+K+ +G G F +V++G + Q     VAVK I    L++ Q     EI  LK L   NIV LLD+  I+G V L+ME C G D+   + + G   SE  IR  ++Q A  +  + + GI+HRD+KP NIL ++ + RK     +  K++DFG ++ + G T   ++  S +Y APE+      +  +D+WS+G  +   +T
Sbjct:    1 MESIGKYEFNRKDLIGHGAFAVVFKGRHKQKHNFEVAVKCINRKNLAKSQSLLGKEIKILKELKHENIVSLLDFQEISGCVYLVMEYCNGGDLAEYLHSKG-CLSEDTIRVLLQQLAGAMSVLRSKGIIHRDLKPQNILLSYSTGRKSNPNNICIKLADFGFARYLQGNTMAATLCGSPMYMAPEVIMSHNYDAKADLWSVGTIIYQCLT 209
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: si:ch73-60h1.1 (si:ch73-60h1.1 [Source:ZFIN;Acc:ZDB-GENE-140106-152])

HSP 1 Score: 116.316 bits (290), Expect = 2.858e-29
Identity = 88/266 (33.08%), Postives = 131/266 (49.25%), Query Frame = 1 
Query:  115 YFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM-SIRASDIYSAPEI---NDYGEANFNSDVWSLG----------------RTVCYMITRDINDLDNYFVSS-------DLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            ++N    LG+G   +V R E  Q     AVKV+      +  RTEI  L  L+  NI+RL + F     + LI+EL  G ++  RI   G  +SE +  + I+Q    + Y+H NG++HRD+KP N+L+   S     KI+DFG+SK+ID    M ++  +  Y APEI   N YG      D+WS+G                R   YM +R +N  D  FVS        +  DL+N ++  DP  RL   + L H ++ G+ +
Sbjct:   27 FYNMGPELGRGATSVVLRCEEKQTEKPYAVKVLKKTIDKKIVRTEIGVLLRLSHPNIIRLKEIFETETEIFLILELVTGGELFDRIVERG-YYSERDAAHVIKQILEAVAYLHENGVVHRDLKPENLLYADLSIDAPLKIADFGLSKIIDEQVTMKTVCGTPGYCAPEILRGNAYGP---EVDMWSVGVILYILLCGFEPFFDQRGDQYMYSRILN-CDYEFVSPWWDEVSLNAKDLVNKLIVLDPHKRLTVKQALEHPWVLGKAA 287
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: plk3 (polo-like kinase 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-030131-6134])

HSP 1 Score: 117.087 bits (292), Expect = 4.760e-29
Identity = 81/260 (31.15%), Postives = 133/260 (51.15%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE--KMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT-----RDINDLD-----------NYFVSSDLYD----LLNGMLEEDPDDRLEADEVLSHCFIT 816
            + K   LG+GGF   Y   ++ +    AVKVI   R+S+ +QR     EI+  K L  +++V+   +F    N+ + +ELC     + I       ++PE+R ++RQ  + L+Y+HN GILHRD+K  N  F +++ +L  ++ DFG++  ++  E  K +I  +  Y APE+ +       SDVWSLG   C M T          LD            Y + S L      L++ +L+++P DRL  D++L+H + T
Sbjct:   59 YCKGKLLGKGGFARCYEMTDLANNKMYAVKVIPQSRVSKPHQREKIINEIELHKSLQHKHVVKFSHHFEDQDNIYIFLELCSRKSLAHIWKARHTLTDPEVRYYLRQIISSLKYLHNKGILHRDLKLGN-FFVNENMEL--RLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTESDVWSLG---CVMYTLLCGNPPFETLDLKETYKCIKEVKYSLPSSLTPSAQKLISSILQKNPCDRLTLDQILAHDYFT 312
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:ZFIN;Acc:ZDB-GENE-050417-76])

HSP 1 Score: 112.079 bits (279), Expect = 3.079e-28
Identity = 77/266 (28.95%), Postives = 133/266 (50.00%), Query Frame = 1 
Query:  115 YFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM-SIRASDIYSAPEINDYGEANFNSDVWSLG----------------RTVCYMITRDINDLDNYFVSS-------DLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNF 837
            ++  ++ LG+G   +VYR      + + AVK++      +  RTEI  L  L+  NI++L + F     + L++EL  G ++  R+   G  +SE +  + ++Q    + Y+H NG++HRD+KP N+L+   +     KI+DFG+SK++D    M ++  +  Y APEI          D+WS+G                R   YM  R +N  +  FVS        +  DL+  ++ +DP  RL   + L H ++TG+ ++NF
Sbjct:   28 FYELESELGRGATSVVYRCRQKGTQKHYAVKMLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPAEISLVLELVTGGELFDRVVEKG-YYSERDAADAVKQVLEAVAYLHENGVVHRDLKPENLLYATSAPDAPLKIADFGLSKIVDDQVTMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGVITYILLCGFEPFFDDRGDQYMFKRILN-CEYEFVSPWWDNVSLNAKDLVKKLIVQDPKKRLTTQQALQHPWVTGK-AVNF 290
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: plk3 (polo-like kinase 3 [Source:NCBI gene;Acc:448451])

HSP 1 Score: 122.094 bits (305), Expect = 1.172e-30
Identity = 81/257 (31.52%), Postives = 130/257 (50.58%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE--KMSIRASDIYSAPEINDYGEANFNSDVWSLG----RTVCYMITRDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            + K   LG+GGF   Y    V      AVKVI + R+++ +QR     EID  + L+ +++V+   +F  + N+ + +E+C     + I        EPE+R F++Q  +GL+Y+H  GILHRD+K  N  F ++S +L  K+ DFG++  ++  E  K +I  +  Y APE+         SD+WSLG      +C     + +DL   +             +SS    LL G+L+  P +RL  D++L H F T
Sbjct:   60 YTKGRLLGKGGFARCYEMTEVATNKTYAVKVIPHSRVAKPHQREKIVNEIDLHRELHHKHVVKFSHHFEDSENIYIFLEICSRKSLAHIWKARHTLLEPEVRYFLKQIISGLKYLHLKGILHRDLKLGN-FFINESMEL--KVGDFGLAARLEPPEQRKKTICGTPNYLAPEVLYRQGHGPESDIWSLGCVMYTLLCGTPPFETSDLKETYRCIKQVKYTLPACLSSAAKHLLMGILKRTPGERLTLDQILEHEFFT 313
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: rtkn2 (rhotekin 2 [Source:Xenbase;Acc:XB-GENE-993318])

HSP 1 Score: 122.479 bits (306), Expect = 1.188e-30
Identity = 84/259 (32.43%), Postives = 131/259 (50.58%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLS-----QYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTV-CYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITG 819
            F   N LG+G F  VYR +++    +VA+K+I    +      Q  R E++    L   +I+ L +YF  +  V LI+E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +N      S  +  KI+DFG++  +     +  ++  +  Y APEI         SDVWSLG  +  +++ R   D D                  FVS +  DL+  +L ++P DRL    VL H F+TG
Sbjct:   12 FKVLNLLGKGSFACVYRAQSINTGIDVAIKMIDKKAMQKVGMVQRVRNEVEIHCQLKHPSILELYNYFEDSNYVYLILEMCHNGEMNRFLKNRKKPFSEDEARHFMHQIVTGMLYLHSHGILHRDLTLSN---LLLSSDMNIKIADFGLATQLKMPNEKHFTMCGTPNYIAPEIATRSAHGLESDVWSLGCMLYTFLVGRPPFDTDTVKNTLNKIVLADYEMPDFVSREAKDLIFQLLRKNPADRLSLSSVLDHAFMTG 267
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: plk3 (polo-like kinase 3 [Source:NCBI gene;Acc:448451])

HSP 1 Score: 121.709 bits (304), Expect = 1.486e-30
Identity = 81/257 (31.52%), Postives = 130/257 (50.58%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE--KMSIRASDIYSAPEINDYGEANFNSDVWSLG----RTVCYMITRDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            + K   LG+GGF   Y    V      AVKVI + R+++ +QR     EID  + L+ +++V+   +F  + N+ + +E+C     + I        EPE+R F++Q  +GL+Y+H  GILHRD+K  N  F ++S +L  K+ DFG++  ++  E  K +I  +  Y APE+         SD+WSLG      +C     + +DL   +             +SS    LL G+L+  P +RL  D++L H F T
Sbjct:   60 YTKGRLLGKGGFARCYEMTEVATNKTYAVKVIPHSRVAKPHQREKIVNEIDLHRELHHKHVVKFSHHFEDSENIYIFLEICSRKSLAHIWKARHTLLEPEVRYFLKQIISGLKYLHLKGILHRDLKLGN-FFINESMEL--KVGDFGLAARLEPPEQRKKTICGTPNYLAPEVLYRQGHGPESDIWSLGCVMYTLLCGTPPFETSDLKETYRCIKQVKYTLPACLSSAAKHLLMGILKRTPGERLTLDQILEHEFFT 313
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: plk3 (polo-like kinase 3 [Source:NCBI gene;Acc:448451])

HSP 1 Score: 121.709 bits (304), Expect = 1.629e-30
Identity = 81/257 (31.52%), Postives = 130/257 (50.58%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE--KMSIRASDIYSAPEINDYGEANFNSDVWSLG----RTVCYMITRDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            + K   LG+GGF   Y    V      AVKVI + R+++ +QR     EID  + L+ +++V+   +F  + N+ + +E+C     + I        EPE+R F++Q  +GL+Y+H  GILHRD+K  N  F ++S +L  K+ DFG++  ++  E  K +I  +  Y APE+         SD+WSLG      +C     + +DL   +             +SS    LL G+L+  P +RL  D++L H F T
Sbjct:   68 YTKGRLLGKGGFARCYEMTEVATNKTYAVKVIPHSRVAKPHQREKIVNEIDLHRELHHKHVVKFSHHFEDSENIYIFLEICSRKSLAHIWKARHTLLEPEVRYFLKQIISGLKYLHLKGILHRDLKLGN-FFINESMEL--KVGDFGLAARLEPPEQRKKTICGTPNYLAPEVLYRQGHGPESDIWSLGCVMYTLLCGTPPFETSDLKETYRCIKQVKYTLPACLSSAAKHLLMGILKRTPGERLTLDQILEHEFFT 321
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: plk3 (polo-like kinase 3 [Source:NCBI gene;Acc:448451])

HSP 1 Score: 121.709 bits (304), Expect = 2.031e-30
Identity = 81/257 (31.52%), Postives = 130/257 (50.58%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE--KMSIRASDIYSAPEINDYGEANFNSDVWSLG----RTVCYMITRDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            + K   LG+GGF   Y    V      AVKVI + R+++ +QR     EID  + L+ +++V+   +F  + N+ + +E+C     + I        EPE+R F++Q  +GL+Y+H  GILHRD+K  N  F ++S +L  K+ DFG++  ++  E  K +I  +  Y APE+         SD+WSLG      +C     + +DL   +             +SS    LL G+L+  P +RL  D++L H F T
Sbjct:   60 YTKGRLLGKGGFARCYEMTEVATNKTYAVKVIPHSRVAKPHQREKIVNEIDLHRELHHKHVVKFSHHFEDSENIYIFLEICSRKSLAHIWKARHTLLEPEVRYFLKQIISGLKYLHLKGILHRDLKLGN-FFINESMEL--KVGDFGLAARLEPPEQRKKTICGTPNYLAPEVLYRQGHGPESDIWSLGCVMYTLLCGTPPFETSDLKETYRCIKQVKYTLPACLSSAAKHLLMGILKRTPGERLTLDQILEHEFFT 313
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk4 (polo like kinase 4 [Source:MGI Symbol;Acc:MGI:101783])

HSP 1 Score: 127.102 bits (318), Expect = 2.483e-32
Identity = 83/260 (31.92%), Postives = 133/260 (51.15%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYN---YRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG-RTVCYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +++ L +YF     V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +NIL T   R +  KI+DFG++  ++    +  ++  +  Y +PEI         SD+WSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT---RNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMS 266
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk4 (polo like kinase 4 [Source:MGI Symbol;Acc:MGI:101783])

HSP 1 Score: 127.102 bits (318), Expect = 2.483e-32
Identity = 83/260 (31.92%), Postives = 133/260 (51.15%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYN---YRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG-RTVCYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +++ L +YF     V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +NIL T   R +  KI+DFG++  ++    +  ++  +  Y +PEI         SD+WSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT---RNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMS 266
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk4 (polo like kinase 4 [Source:MGI Symbol;Acc:MGI:101783])

HSP 1 Score: 127.102 bits (318), Expect = 2.505e-32
Identity = 83/260 (31.92%), Postives = 133/260 (51.15%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYN---YRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG-RTVCYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +++ L +YF     V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +NIL T   R +  KI+DFG++  ++    +  ++  +  Y +PEI         SD+WSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT---RNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMS 266
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk4 (polo like kinase 4 [Source:MGI Symbol;Acc:MGI:101783])

HSP 1 Score: 127.102 bits (318), Expect = 2.505e-32
Identity = 83/260 (31.92%), Postives = 133/260 (51.15%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYN---YRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG-RTVCYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +++ L +YF     V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +NIL T   R +  KI+DFG++  ++    +  ++  +  Y +PEI         SD+WSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT---RNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMS 266
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk4 (polo like kinase 4 [Source:MGI Symbol;Acc:MGI:101783])

HSP 1 Score: 127.102 bits (318), Expect = 2.507e-32
Identity = 83/260 (31.92%), Postives = 133/260 (51.15%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYN---YRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG-RTVCYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +++ L +YF     V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +NIL T   R +  KI+DFG++  ++    +  ++  +  Y +PEI         SD+WSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT---RNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMS 266
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|Q8T2I8|SEPA_DICDI (Serine/threonine-protein kinase sepA OS=Dictyostelium discoideum OX=44689 GN=sepA PE=2 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 3.588e-33
Identity = 88/265 (33.21%), Postives = 138/265 (52.08%), Query Frame = 1 
Query:   88 KSMTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQ----RTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT-----RDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 813
            K   T+G Y  N    +G+GGFG VY+G +++D   VA+K I   ++ + Q      EID LK LN  NIV+ + Y     N+ +++E  E G +   I+  G+ F E  +  +IRQ   GL Y+H  G++HRDIK ANIL T + +    K++DFG++   D T   ++  +  + APEI +   A   SD+WS+G TV  ++T      D+  +   F             +S  L D L    ++DP+ R+ A ++L H +I
Sbjct:   10 KKNVTVGNY--NLGVVIGKGGFGTVYQGLDIEDGDFVAIKQINLTKIPKDQLQGIMNEIDLLKNLNHANIVKYIKYVKTKDNLYIVLEYVENGSLSGIIKKFGK-FPETLVCVYIRQVLEGLVYLHEQGVVHRDIKGANILTTKEGK---IKLADFGVATKFDDTSAAAVVGTPYWMAPEIIELNGATTKSDIWSVGCTVIELLTGSPPYYDLGQMPALFRIVQDDCPPLPEGISPPLKDWLMQCFQKDPNLRISAQKLLKHKWI 268
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|Q64702|PLK4_MOUSE (Serine/threonine-protein kinase PLK4 OS=Mus musculus OX=10090 GN=Plk4 PE=1 SV=2)

HSP 1 Score: 127.102 bits (318), Expect = 1.754e-31
Identity = 83/260 (31.92%), Postives = 133/260 (51.15%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYN---YRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG-RTVCYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +++ L +YF     V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +NIL T   R +  KI+DFG++  ++    +  ++  +  Y +PEI         SD+WSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT---RNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMS 266
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|Q5R9Z7|PLK4_PONAB (Serine/threonine-protein kinase PLK4 OS=Pongo abelii OX=9601 GN=PLK4 PE=2 SV=1)

HSP 1 Score: 126.716 bits (317), Expect = 2.236e-31
Identity = 87/264 (32.95%), Postives = 136/264 (51.52%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVI---YNYRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM--SIRASDIYSAPEINDYGEANFNSDVWSLGRTV-CYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +I+ L +YF  +  V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +N+L T   R +  KI+DFG++  +    +   ++  +  Y +PEI         SDVWSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++ QNS
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT---RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSMEAKDLIHQLLRRNPADRLSLSSVLDHPFMS-QNS 269
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|B2GUY1|PLK4_RAT (Serine/threonine-protein kinase PLK4 OS=Rattus norvegicus OX=10116 GN=Plk4 PE=2 SV=1)

HSP 1 Score: 126.331 bits (316), Expect = 2.906e-31
Identity = 83/260 (31.92%), Postives = 132/260 (50.77%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYN---YRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG-RTVCYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +++ L +YF     V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +NIL T   R +  KI+DFG++  +     +  ++  +  Y +PEI         SD+WSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSESEARHFMHQIITGMLYLHSHGILHRDLTLSNILLT---RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMS 266
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|O00444|PLK4_HUMAN (Serine/threonine-protein kinase PLK4 OS=Homo sapiens OX=9606 GN=PLK4 PE=1 SV=3)

HSP 1 Score: 125.176 bits (313), Expect = 7.223e-31
Identity = 85/264 (32.20%), Postives = 135/264 (51.14%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYN---YRLSQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM--SIRASDIYSAPEINDYGEANFNSDVWSLGRTV-CYMITRDINDLDNY----------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            F   N LG+G F  VYR E++     VA+K+I     Y+    QR  + N   ++C+    +I+ L +YF  +  V L++E+C  G+M   ++N  + FSE E R+F+ Q  TG+ Y+H++GILHRD+  +N+L T   R +  KI+DFG++  +    +   ++  +  Y +PEI         SDVWSLG      +I R   D D                  F+S +  DL++ +L  +P DRL    VL H F++  +S
Sbjct:   12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQR--VQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT---RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSS 270
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: F6I0I4 (Protein kinase domain-containing protein OS=Vitis vinifera OX=29760 GN=VIT_04s0044g00630 PE=4 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 1.241e-31
Identity = 82/255 (32.16%), Postives = 133/255 (52.16%), Query Frame = 1 
Query:  100 TIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRT----EIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMI-DGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT-------RDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQN 825
            TIG Y    K  +GQG    V++ E       VA+K +Y  +L++  +T    EI+ L  ++  NI+RLL  F   G + L++E C G D+ES I++ GR   E   R F++Q   GL  +H++ I+HRD+KP NIL +     ++ KI+DFG+S+ +  G    ++  + +Y APE+  + + +   D+WSLG  +  ++        R    L +  +  D  DL   +L  +P  RL  DE   H F+ G+ 
Sbjct:    6 TIGEYTVRSK--VGQGPQSTVWKAEQKCSGEVVALKQVYLSKLNRNLKTSLDCEINFLSSVSHPNIIRLLHVFQAEGCIFLVLEFCSGGDLESYIRHHGR-VQEWVARRFMQQLGAGLEVLHSHHIIHRDLKPGNILLSGPESDVLLKIADFGLSRTVHPGEHAETVCGTPLYMAPEVLRFKKYDEKVDMWSLGAILFELLNGYPPFCGRTNVQLISPGLHPDCVDLCTKLLSTNPVHRLSFDEFCRHRFLRGKG 257
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: A0A137NX97 (Pkinase-domain-containing protein OS=Conidiobolus coronatus (strain ATCC 28846 / CBS 209.66 / NRRL 28638) OX=796925 GN=CONCODRAFT_80129 PE=3 SV=1)

HSP 1 Score: 129.413 bits (324), Expect = 3.089e-31
Identity = 85/275 (30.91%), Postives = 138/275 (50.18%), Query Frame = 1 
Query:  115 YFNKKNF-----LGQGGFGMVYRGENVQDRTNVAVKVIYNYRLS---QYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM--SIRASDIYSAPEI---NDYGEANFNSDVWSLGRTVCYMITRDINDLDNY-----------------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            Y  KKN+     +G G FG V   + +  + +VA+KVI    +         E++ ++ L   NIV  +DYF       +++EL EG ++  R+  +GR  +E +  ++I+QT   + Y+H+N I+HRDIKP N+LF  K       ++DFGISK++   ++M  +I  S  Y+APE+     YG+     D+WS+G  V YM+    N    Y                        +S D  D + G+L+ DPD+RL   + L H +I G+++
Sbjct:   18 YERKKNYEQSKVIGTGSFGQVRLAKKLDTQDDVAIKVILKKSMVGNFHLVYRELEAMRKLQHPNIVHFIDYFESKNKFYMVLELAEGGELFDRLYELGR-LTEKDSISYIKQTLQAVEYLHSNNIVHRDIKPENLLFKSKDHDSPLLLADFGISKILQKEDQMLSTICGSHGYTAPEVLLGKKYGKP---IDLWSIG-IVTYMLLAGSNPFRMYEQTSEWIPAMSSSKINFPSKYWKLISEDAKDFVKGLLKGDPDERLTTTQALKHPWIVGKDA 287
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: W4ZGD8 (Protein kinase domain-containing protein OS=Strongylocentrotus purpuratus OX=7668 PE=4 SV=1)

HSP 1 Score: 133.265 bits (334), Expect = 3.607e-31
Identity = 89/276 (32.25%), Postives = 138/276 (50.00%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRG-ENVQDRTNVAVKVIYNYRLSQYQ---RTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLV-------YKISDFGISKMIDG-TEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTV--------------------CYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQN 825
            M  I  Y +NKK+ +G G F +V+RG E  +    VA+K I    LS+ Q     EI+ LK L+  N+V LL +   T ++ ++ME C G   +   +I    SE  IR F+ Q A  ++ IH  GI+HRD+KP N+L +H S+  V        KI+DFG ++ ++G     ++  S +Y APE+      +  +D+WS+G  +                     YM  R ++       S  L DLL  +L+ +  DR+E D+  SH F+ G+N
Sbjct:    1 MEHIDEYEYNKKDIIGHGAFAIVFRGRERKRPDQTVAIKCINKKNLSKSQTFPEKEIEILKELHHGNVVSLLHFKETTSSLFMVMEFCNGGDLADYLHIKGTLSEDTIRFFLGQIACAMKAIHEKGIIHRDLKPQNLLLSHNSKHKVPHPNEIHLKIADFGFARFLEGDMMAATLCGSPLYMAPEVITSQHYDAKADLWSIGTIIFQCLTGSAPFKAANPPELKKLYMKARTLDPNIPPGTSKALKDLLIRLLKRNQKDRIEFDKFFSHDFL-GKN 275
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: F2UMG6 (PLK/SAK protein kinase OS=Salpingoeca rosetta (strain ATCC 50818 / BSB-021) OX=946362 GN=PTSG_09382 PE=4 SV=1)

HSP 1 Score: 132.88 bits (333), Expect = 5.265e-31
Identity = 90/277 (32.49%), Postives = 147/277 (53.07%), Query Frame = 1 
Query:   97 TTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQ------RTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQN-IGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEK----MSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT-----------------RDINDLDNYF---VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSL 831
            +TIG Y    + +LGQGGF  VYR  ++  + NVA+KVI   +L + Q      R EI    GL  ++I+RL  YF     V L++EL E G+++S IQ+ + R+ +E E R +  QTA  + Y+H +GI+HRDI   N+L T   ++L  K+ DFG++K   G++     +++  +  + +PE+    + +F  D++SLG  + Y I                  R + ++D +    V  D  DL+  M+++D   R    +VL H FIT +N +
Sbjct:    6 STIGAYSL--QAYLGQGGFARVYRAVDLSSKRNVALKVIDKAKLVKDQDLVGRVRREIQLHSGLLHQHILRLYHYFEDDKGVYLVLELAEYGNIQSYIQDTLQRKLTEVEAREYFAQTAQAVEYLHASGIVHRDISNTNVLLT---KELRVKLGDFGLAKKTTGSDDDAALVTLCGTPNFLSPEVVARNKQSFPVDIFSLGCLLYYFIVGKPPFDTRGNDAVRETLRKVAEVDFHIPDTVPQDAADLIRAMMQKDASARPSIRDVLRHPFITRRNQI 277
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: E4XMV0 (Protein kinase domain-containing protein OS=Oikopleura dioica OX=34765 GN=GSOID_T00015497001 PE=4 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 6.217e-31
Identity = 87/276 (31.52%), Postives = 138/276 (50.00%), Query Frame = 1 
Query:  106 GYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRT----EIDNLKGLNCRNIVRLLDYFTITGNVILIMELC-EGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSR---KLVYKISDFGISKMIDGTE-KMSIRASDIYSAPEINDYGEANFNSDVWSLGRTV--C------------------YMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNFFNF 846
            G Y + KKN +G G F +V++G++ Q++ +VAVKVI   ++ +        EI+ LK L   NIV LLD+      ++L+ME C  GD+   +Q  G   SE  IR F++Q    ++ +H  GI+HRD+KP NIL    S    +L  KI+DFG ++ + GT+   ++  S +Y APE+         +D++S+G  V  C                  Y  T  +        S+ L DL+  +L  +P +RL + +   H FI  ++  N   F
Sbjct:    8 GKYEYEKKNLVGHGAFAIVFKGKHRQEKKSVAVKVIQRSKIGKPADKLLGKEIEILKSLKHENIVSLLDFEDNNEQIVLVMEYCNAGDLAEYLQKQG-TLSEDTIRTFLQQIVAAMKVLHEKGIIHRDLKPGNILLNRDSSENNRLRVKIADFGFARHLQGTDMAATLCGSPMYMAPEVLMGHSYCAKADLYSIGTIVYQCLTGRAPFHASTPPELRAFYERTHTLKPSIPSTTSAALKDLICSLLIRNPRERLSSTDFFRHPFIKTRSGSNRRGF 282
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: plk3 (polo like kinase 3 [Source:NCBI gene;Acc:103024965])

HSP 1 Score: 118.242 bits (295), Expect = 1.551e-29
Identity = 79/256 (30.86%), Postives = 130/256 (50.78%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQRTEIDN----LKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE--KMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITR-------DINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSH 804
            + K   LG+GGF   Y   ++      AVKVI   R+S+ +QR +I N     K L  +++V+   +F    N+ + +ELC     + I       ++PE+R ++RQ  +GL+Y+HN GILHRD+K  N  F +++ +L  ++ DFG++  ++  E  K +I  +  Y APE+ +       SDVWSLG   C M T        +  DL   +             +S     L++ +L+++P DRL  D++L H
Sbjct:   65 YTKGKLLGKGGFARCYEMTDLASSRMYAVKVIPQSRVSKPHQREKITNEIELHKTLQHKHVVKFSHHFEDQDNIYIFLELCSRKSLAHIWKARHTLTDPEVRYYLRQIISGLKYLHNKGILHRDLKLGN-FFVNENMEL--RLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTESDVWSLG---CVMYTLLCGNPPFETLDLKETYKCIKEVRYSLPPSLSPAAQKLISAVLQKNPSDRLTLDQILVH 314
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: ulk1b (unc-51 like autophagy activating kinase 1 [Source:NCBI gene;Acc:103042154])

HSP 1 Score: 115.931 bits (289), Expect = 1.509e-28
Identity = 87/278 (31.29%), Postives = 137/278 (49.28%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRT-NVAVKVIYNYRLSQYQR---TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTH------KSRKLVYKISDFGISKMI-DGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT-------RDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSL 831
            M T+G + F++K+ +G G F +V++G N +     VAVK I    L++ Q     EI  LK L   NIV L D+     +V L+ME C G D+   + + G   SE  IR F++Q A  +R +   GI+HRD+KP NIL +H       S     KI+DFG ++ + +     ++  S +Y APE+      +  +D+WS+G  V   +T           DL  ++              SS L  LL G+L+ +  DR++ DE   H F+   +++
Sbjct:    1 METVGKFEFSRKDLIGHGAFAVVFKGRNREKHDWEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALHDFQETASSVYLVMEYCNGGDLADYLHSKG-TLSEDTIRVFLQQIAGAMRVLQAKGIIHRDLKPQNILLSHPAGRKTHSNNTCIKIADFGFARHLQNNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTIVFQCLTGKAPFQASSPQDLRLFYEKNKNLSPNIPRETSSHLRHLLLGLLQRNHKDRMDFDEFFKHPFLEASSTM 277
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: ulk1b (unc-51 like autophagy activating kinase 1 [Source:NCBI gene;Acc:103042154])

HSP 1 Score: 115.546 bits (288), Expect = 1.590e-28
Identity = 87/278 (31.29%), Postives = 137/278 (49.28%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRT-NVAVKVIYNYRLSQYQR---TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTH------KSRKLVYKISDFGISKMI-DGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT-------RDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSL 831
            M T+G + F++K+ +G G F +V++G N +     VAVK I    L++ Q     EI  LK L   NIV L D+     +V L+ME C G D+   + + G   SE  IR F++Q A  +R +   GI+HRD+KP NIL +H       S     KI+DFG ++ + +     ++  S +Y APE+      +  +D+WS+G  V   +T           DL  ++              SS L  LL G+L+ +  DR++ DE   H F+   +++
Sbjct:    1 METVGKFEFSRKDLIGHGAFAVVFKGRNREKHDWEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALHDFQETASSVYLVMEYCNGGDLADYLHSKG-TLSEDTIRVFLQQIAGAMRVLQAKGIIHRDLKPQNILLSHPAGRKTHSNNTCIKIADFGFARHLQNNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIGTIVFQCLTGKAPFQASSPQDLRLFYEKNKNLSPNIPRETSSHLRHLLLGLLQRNHKDRMDFDEFFKHPFLEASSTM 277
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: ulk1a (unc-51 like autophagy activating kinase 1a [Source:ZFIN;Acc:ZDB-GENE-080723-31])

HSP 1 Score: 114.39 bits (285), Expect = 3.569e-28
Identity = 75/209 (35.89%), Postives = 112/209 (53.59%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDR-TNVAVKVIYNYRLSQYQR---TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKIS-----DFGISKMIDG-TEKMSIRASDIY-SAPEINDYGEANFNSDVWSLGRTVCYMIT 687
            M +IG + FN+K+ +G G F +V+RG + Q     VAVK I    L++ Q     EI  LK L   NIV LLD+  I+G V L+ME C G   +   + G   SE  IR+F++Q A  +  +   GI+HRD+KP NIL T+ S +     S     DFG ++ + G T   ++  S +Y  APE+      +  +D+WS+G  +   +T
Sbjct:    1 MESIGKFEFNRKDLIGHGAFAVVFRGRHKQKHDLEVAVKCINKKNLAKSQSLLGKEIKILKELKHENIVGLLDFQEISGCVYLVMEYCNGGDLAEYLHKG-SLSEDTIRSFLQQIAAAMSVLRCKGIIHRDLKPQNILLTYSSGRRANPNSICVKLDFGFARYLQGNTMAATLCGSPMYMQAPEVIMSQNYDAKADLWSVGTIIFQCLT 208
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: si:ch73-60h1.1 (calcium/calmodulin-dependent protein kinase type IV-like [Source:NCBI gene;Acc:103036728])

HSP 1 Score: 111.694 bits (278), Expect = 1.229e-27
Identity = 85/259 (32.82%), Postives = 128/259 (49.42%), Query Frame = 1 
Query:  136 LGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM-SIRASDIYSAPEI---NDYGEANFNSDVWSLG----------------RTVCYMITRDINDLDNYFVSS-------DLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            LG+G   +V+R E  Q     A KV+      +  RTEI  L  L+  NI+RL + F     + LI+EL  G ++  RI   G  +SE +  + I+Q    + Y+H NG++HRD+KP N+L+   S     KI+DFG+SK+ID    M ++  +  Y APEI   N YG      D+WS+G                R   YM +R +N  D  FVS        +  DL++ ++  DP  RL   + L H ++ G+ +
Sbjct:   34 LGRGATSVVFRCEEKQTEKPYAAKVLKKTIDKKIVRTEIGVLLRLSHPNIIRLKEIFETETEISLILELVTGGELFDRIVERG-YYSERDAAHVIKQILEAVAYLHENGVVHRDLKPENLLYADLSIDAPLKIADFGLSKIIDEQVTMKTVCGTPGYCAPEILRGNAYGP---EVDMWSVGVILYILLCGFEPFFDPRGDQYMYSRILN-CDYEFVSPWWDEVSLNAKDLVSKLIVLDPHKRLSVQQALEHPWVLGKAA 287
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: STK36 (serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209])

HSP 1 Score: 112.079 bits (279), Expect = 6.123e-28
Identity = 74/255 (29.02%), Postives = 131/255 (51.37%), Query Frame = 1 
Query:  136 LGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQ----RTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKM--IDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG---------------RTVCYMITRDINDLDNY--FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSL 831
            +G+G FG VY+G        VA+K I     S  +    R EID ++GL   NIV++LD F     V+++ +  EG++   +++ G    E ++R    Q  + L Y+H++ ILHRD+KP NIL     +  V K+ DFG ++   I+     SI+ + +Y +PE+ +    +  +D+WS+G                ++  +++  I D   +   +SS+  + L G+L ++P  RL    +L H F+ G++S+
Sbjct:   10 IGEGSFGKVYKGRKRYTGQVVALKFIPKVGRSDKELRNLRREIDIMRGLQHPNIVQMLDSFETDKEVVVVTDYAEGELFQILEDDG-NLPEEQVREIACQLVSALYYLHSHRILHRDMKPQNILL---GKGGVVKLCDFGFARAMSINTLVLTSIKGTPLYMSPELVEEKPYDHTADLWSMGCILYELFVGTPPFYTNSIFQLVSLIIKDPVKWPKNMSSEFRNFLQGLLTKEPKLRLSWPALLHHPFVAGKSSI 260
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002824.1 (pep scaffold:Pmarinus_7.0:GL476598:1893846:1903215:-1 gene:ENSPMAG00000002574.1 transcript:ENSPMAT00000002824.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 102.449 bits (254), Expect = 8.939e-26
Identity = 58/198 (29.29%), Postives = 102/198 (51.52%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQ-----RTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEP-EIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISK--MIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMI 684
            F   N LG+G F  VYR  +      VA+K+I    + +       R E++    L    I+ +   F     V L++E+C  G+M   ++N GR F+E  E R F+R+ ++GL Y+H +G++HRD+  AN+L    +  +  +I+DFG++    + G  ++++  +  Y +PE+   G     +D W+LG     M+
Sbjct:   13 FQVMNLLGKGSFACVYRARSCHTGIEVAIKMIDKQAMRRAGMVDRVRAEVEIHSQLKHPAILEMYGCFEDDNYVYLVLEMCHNGEMSRYLKNQGRPFTEEQEARQFLREISSGLLYLHAHGVIHRDLTLANLLL---ASDMSTRIADFGLAARLPLPGESRLTVCGTPNYMSPEVASRGPHGTPADAWALGCAAYAML 207
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: plk3 (polo-like kinase 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-030131-6134])

HSP 1 Score: 102.064 bits (253), Expect = 1.347e-24
Identity = 71/257 (27.63%), Postives = 119/257 (46.30%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQR-----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE--KMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITR----DINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            +++   LG+GGF   Y         + A K+I   R+ +         EI   + L+ R+IV+ +  F     + +I+ELC G   + +    +  +E E++ ++RQ  +GLRY+H  G++HRD+K  N   T     +  KI D G++  ++  E  K ++  +  Y APE+ +       +D+WSLG  V  M+        +DL N +             +S    DLL   L  DPD R    ++ SH F+T
Sbjct:   27 YSRGRLLGKGGFARCYLVTEEYTGCHFAAKIITKQRVEKPGHRAKIEQEISLHRKLHHRHIVQFISSFKDENFIYIILELCNGQSLAHMLRSRKVLTETEVKYYLRQLISGLRYLHQCGVVHRDLKLGNFFVTD---SMEVKIGDLGLATTLEPPEMRKRTVCGTPNYLAPEVLNKRGHGPEADIWSLGCAVFTMLAGRPPFSTSDLANTYACIRSGRFNFPPSLSHAARDLLTSALTPDPDLRASLLDLQSHPFLT 280
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: stk33 (serine/threonine kinase 33 [Source:ZFIN;Acc:ZDB-GENE-040724-242])

HSP 1 Score: 97.8265 bits (242), Expect = 3.914e-24
Identity = 79/276 (28.62%), Postives = 124/276 (44.93%), Query Frame = 1 
Query:  109 YYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLS----QYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSR-----KLVYKISDFGISKMIDGTEKMSIRAS----DIYSAPEINDYGEANFNSDVWSLGRTVCYMITRD-----INDLDNYF-----------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            YY   ++  LG G FG VY   +V+     A+K +   R      +    E+  LK +  +NI+ L +       V L+MELCE G++ + ++   R  SE E R+     A  + Y+H + I+HRD+K  NIL            L  +++DFG+S + +G    S+  S     IY A E+    + +   DVWS+G  + YM+         +  +  F                 VS    +LL G+L+ DP  RL A E+L   ++TG  S
Sbjct:    4 YYRLGRQ--LGSGSFGTVYEATHVETGVKWAIKTVNKERAGSSGVRLLEREVVILKRVQHQNIIHLEEVLETHKRVYLVMELCELGELRAVLEQRKR-LSEAEARHVAHSLAGAIAYLHKHDIVHRDLKLENILAKSSEPHEGIDHLDIRVTDFGLSAVREGNGAASMLQSPCGTPIYMAAEVIQSQDYSQQCDVWSIG-VILYMLLCGEPPFMAHSQEKLFELIIKGELSFTQPAWEEVSESAKELLRGLLKVDPAHRLTASELLHDHWVTGDTS 275
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: mylk3 (myosin light chain kinase 3 [Source:NCBI gene;Acc:561635])

HSP 1 Score: 95.9005 bits (237), Expect = 2.579e-23
Identity = 70/231 (30.30%), Postives = 121/231 (52.38%), Query Frame = 1 
Query:   76 VV*QKSMTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVI--YNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIR-ASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSDLYDLLNGML 756
            +V  +S+T   Y+  +  + LG G FG V R +       +A KVI   + +  +  + EI+ +  LN  N+V+L D +    ++ LIME  EG ++ +RI +     SE +   F+RQ   G+ Y+H   ILH D+KP NIL   +    + KI DFG+++     EK+ +   +  + APE+ +Y   +F +D+WS+G  + YM+   ++     F+  D  + LN ++
Sbjct:   13 IVSPRSITVGTYFSLSHSDVLGGGRFGRVMRCQEKSSGLTLAAKVIRVKSPKEKEEVKNEINIMNQLNHVNLVQLFDAYESRSDITLIMEYVEGGELFNRIID-QSGLSELDTVLFVRQICEGVHYMHQQYILHLDLKPENILCLSRWGYQI-KIIDFGLARRYKPREKLKVSFGTSEFLAPEVVNYEFVSFPTDMWSVG-VITYMLLSGLSP----FLGDDESETLNNIV 236
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 107.842 bits (268), Expect = 8.923e-27
Identity = 77/253 (30.43%), Postives = 131/253 (51.78%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVK-VIY--NYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITR-----DINDLDNYFV------------SSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 813
            ++ K  +G+G +G+VY+  N      VA+K V+Y  +  L+     EI  LK LN  NIV+   +   +  + +++E C  G +   I       SE E + ++ QT  GL+Y+H  G++HRDIK ANIL +  +     K++DFG+S +++ +  +++  +  + APEI     A+  SD+WSLG TV  M+T+     ++ D + Y+             S  L D L+    ++   R  AD++L H +I
Sbjct:   25 YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIM-AEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADN---TVKLADFGVSTIVNSSA-LTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWI 272
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 97.0561 bits (240), Expect = 4.654e-23
Identity = 85/276 (30.80%), Postives = 125/276 (45.29%), Query Frame = 1 
Query:  124 KKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQ----------RTEIDNLKGLNCRNIVRLLDYFTITGNVILIME-LCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGI---SKMIDGTEKMSIRASDIYSAPEINDYGEA-NFNSDVWSLGRTVCYMIT--RDINDLDNY---------------------FVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNF 837
            K   +G+G FG VY   NV     +AVK +   + S             R+E+  LK L+  NIV+ L +        L +E +  G + S I+  GR F EP I++   Q   GL Y+H+ GILHRD+K  N+L        + KISDFGI   SK I     M++R +  + APE+ D  +  +   D+WSLG  V  M    R  ++L+                        +S    + L+   E +P+ R  A+E+LSH F     + NF
Sbjct: 1177 KGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGR-FDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDG---ICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETFNF 1448
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: CMK2 (Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005376])

HSP 1 Score: 93.5893 bits (231), Expect = 3.753e-22
Identity = 75/275 (27.27%), Postives = 124/275 (45.09%), Query Frame = 1 
Query:  115 YFNKKNF-----LGQGGFGMVYRGENVQDRTNVAVKVIYNYRLS------QYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDI--YSAPEINDYGEANFNSDVWSLG----RTVC---------------------YMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQ 822
            Y N+ N+     LG G FG+V +   +    +VA+K++    L       Q    E+  L+ L+  NIV   D+F       ++ +L  G ++  RI + G+ F+E +    I Q    + Y+H+  ++HRD+KP N+L+  KS      I+DFGI+K + G E +  +A+    Y APE+          D+WS+G      +C                     Y +T  +   DN  +S D+   +   L  +P DR  A E+L   +IT +
Sbjct:   41 YVNRTNYIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGK-FTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDN--ISIDVKRFILKALRLNPADRPTATELLDDPWITSK 312
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: CMK1 (Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication [Source:SGD;Acc:S000001910])

HSP 1 Score: 92.0485 bits (227), Expect = 1.362e-21
Identity = 59/197 (29.95%), Postives = 103/197 (52.28%), Query Frame = 1 
Query:  115 YFNKKNF-----LGQGGFGMVYRGENVQDRTNVAVKVIYNYRLS------QYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDI--YSAPEINDYGEANFNSDVWSLG 663
            Y NKK +     LG G FG+V + +N +   +VAVK++    L       +    E+D L+ L+  NIV   D+F       +I +L +G ++  RI   G+ F+E +    + +  + ++Y+H+  I+HRD+KP N+L+  KS +    ++DFGI+K +   E++  + +    Y APE+          D+WS+G
Sbjct:   31 YVNKKKYVFGKTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIVAFKDWFESKDKFYIITQLAKGGELFDRILKKGK-FTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWSIG 226
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603])

HSP 1 Score: 90.5077 bits (223), Expect = 6.857e-21
Identity = 69/262 (26.34%), Postives = 125/262 (47.71%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYR-----GENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMI--DGTEKMSIRASDIYSAPEI--NDYGEANFNSDVWSLGRTVCYMI-------TRDINDL-------DNYF-----VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITG 819
            +++ +FLG+GGF   ++     GE    +T VA   I + +  +   +EI   K ++  NIV+ +D F    NV +++E+C       +    +  +EPE+R F  Q    ++Y+H+  ++HRD+K  NI F         KI DFG++ ++  +   K +I  +  Y APE+    +   +F  D+WSLG  +  ++        RD+N +       D  F     +S +   L+  +L  DP +R    E++ + +  G
Sbjct:   82 YHRGHFLGEGGFARCFQIKDDSGEIFAAKT-VAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYN---LKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFRG 339
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO37799 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEV7])

HSP 1 Score: 125.176 bits (313), Expect = 2.004e-34
Identity = 84/270 (31.11%), Postives = 137/270 (50.74%), Query Frame = 1 
Query:  100 TIGYYYFNKKNFLGQGGFGMVYRGENVQDRT-NVAVKVIYNYRLSQYQR---TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRK------LVYKISDFGISKMIDGTEKMS--IRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT-------RDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 813
            T+G +++NKK+ +G G F +V++G++ +     VAVKVI    LS+ Q     EI  LK L   N+V L D   +  +V L+ME+       R+   G   SE  IR F++Q A+ +  + + GI+HRD+KP N+L +H +        +  KI+DFG ++ + G E M+  +  S +Y APE+      +  +D+WSLG  V   +T            L  ++              SS L  LL G+L+ +P DR++  +  +H F+
Sbjct:    4 TVGEFFYNKKDLIGHGAFAVVFKGQHKKKSDFVVAVKVISKKNLSKTQSLLAKEIKILKELQHENVVSLFDCQELPSSVYLVMEVLYICQMLRLTKKGT-LSEDTIRMFLQQIASAMNALQSKGIVHRDLKPQNLLLSHSAASHPSPADIRIKIADFGFARFLPG-EMMAATLCGSPMYMAPEVIMSKAYDARADLWSLGTIVYQCLTGKAPFQANSPQALKKFYEKNKNVCPNIPAGTSSQLKHLLMGLLKRNPKDRMDFGDFFTHPFL 271
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO41399 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4I8])

HSP 1 Score: 110.538 bits (275), Expect = 1.939e-28
Identity = 79/252 (31.35%), Postives = 123/252 (48.81%), Query Frame = 1 
Query:  136 LGQGGFGMVYRGENVQD-RTNVAVKVIYNYRLSQYQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGIS-KMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMI-------TRDINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 813
            LGQG +  VY+     D R  VA+K I    LS+       TEI+ L+ L   +IV+L D+     ++ LIME C G   SR  +  R   E   R F+RQ A  L+Y+ +  + H D+KP N+L + +    V KI+DFG + K+   +E  +IR S +Y APE+      + + D+WS+G  +   +       ++   +L+                VS+D  DLL  +L+ DP  R+  +   +H FI
Sbjct:   23 LGQGSYATVYKAFKKGDNRDVVAIKCIKKKTLSKAATENLLTEIELLRNLEHEHIVQLKDFQWDENHIFLIMEYCGGGDLSRFIHSKRALPERMARKFLRQLACALQYMRSYDVAHMDLKPQNLLLSSRHNP-VLKIADFGFAQKLHPNSEASNIRGSPLYMAPEMICCQSYDASVDLWSVGVILYETLFGEPPFKSKTFVELEAKLRSSEPIKLPPGPRVSADCRDLLIALLQRDPKQRISFEAFFTHPFI 273
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO49138 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH03])

HSP 1 Score: 107.071 bits (266), Expect = 1.343e-27
Identity = 79/252 (31.35%), Postives = 121/252 (48.02%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQR----TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGT--EKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITR-------DINDL------DNY-----FVSSDLYDLLNGMLEEDPDDRLEADEVL 798
            + K + +G+G FG  +  E+ Q +   A+K +    +    R     E+  L  L  RNIVR  D F  TG   ++ME  EG D+ ++I+     FS   I N++ Q    L++IH   ILHRD+K  NI  T      V KI DFGI++++D T     +   +  Y +PEI      N  SD+W+LG  +  + TR       ++ +L       NY     F    L DL+  ML+ +P DR  A +++
Sbjct:    4 YQKIDIIGKGTFGSAWLVESRQSKRLYALKELNATAMPSEDRHLALNEVKILSTLKHRNIVRYRDAFEETGRFYIVMEYAEGGDLHTKIKQAVEPFSSERILNWLAQLLLALKHIHGQNILHRDLKTQNIFLTKDD---VVKIGDFGIARILDSTCDHARTTVGTPYYLSPEICQRQPYNNKSDIWALGCVLYELTTRTHPFTADNLTNLVVKILHGNYPPIPRFYGPLLEDLVAVMLKINPADRPSAKQLI 252
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO35437 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLH0])

HSP 1 Score: 105.145 bits (261), Expect = 1.964e-26
Identity = 76/249 (30.52%), Postives = 118/249 (47.39%), Query Frame = 1 
Query:  136 LGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQ-----RTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMIT---------------RDINDLDNYF---VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 813
            LG+G FG VY     + +  VA+KV++  +L +       R EI+    L   NI+RL  YF     V LI+E        +      +F E     +IRQ A  L Y H+  ++HRDIKP N+L  +K      KI+DFG S     + + ++  +  Y  PE+ +  E +   D+WS+G  +CY                  R I+ +D  F   VS    DL++ +L+ +P++RL    VL+H +I
Sbjct:   54 LGKGKFGNVYLAREKKSKYIVALKVLFKSQLQKSNVEHQLRREIEIQSHLRHNNILRLFGYFYDDTRVYLILEYAPRGELYKELTACEKFDEKRAAKYIRQLADALAYCHSKKVIHRDIKPENLLLNYKGD---IKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGKEHDEKVDLWSIG-VLCYEFLVGKPPFEAEGHNETYRRISRVDLRFPSHVSPGARDLISKLLQHNPNNRLPLKAVLNHPWI 298
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO34707 (Serine/threonine-protein kinase PLK4 [Source:UniProtKB/Swiss-Prot;Acc:A7SNN5])

HSP 1 Score: 107.071 bits (266), Expect = 4.889e-26
Identity = 77/261 (29.50%), Postives = 125/261 (47.89%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRL-SQYQRTEIDNLKGLNCR----NIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLG------------------RTVCYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQ 822
            F   + LG+GGF  VYRG  +     VA+K+I    + +      + N   ++CR    +I+ L  YF     V L++EL E G+    ++  G    E E+R  + Q   G+ Y+H++GI+HRD+   NIL    S  +  KI+DFG++  +     +  ++  +  Y +PEI         SDVWS+G                  R+    +     D+ N+ VS +  DL++ +L+++P DRL    +L H FIT Q
Sbjct:   13 FQVLDLLGKGGFACVYRGRCLATGQEVAIKMIDKKAMRTAGMVNRVCNEVEIHCRLKHPSILELYTYFEDDNYVYLVLELAENGEANRYLRKQGHTLKESEVRRIMLQVVKGVLYLHSHGIIHRDLSLGNILL---SSDMDAKIADFGLATRLSLPDEKHYTMCGTPNYISPEIATRDPHGLESDVWSIGCMLFTLLVGKPPFDTEAVRSTLNKVVLAEYDIPNH-VSIEARDLISKLLKKNPQDRLTLSGILDHPFITNQ 269
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: plk3 (polo like kinase 3 [Source:NCBI gene;Acc:101155385])

HSP 1 Score: 125.176 bits (313), Expect = 6.717e-32
Identity = 81/261 (31.03%), Postives = 131/261 (50.19%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQRTEIDN----LKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTE--KMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITR-------DINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITG 819
            ++K   LG+GGF   Y   ++      AVKVI   R+S+ +QR +I N     + L  +++V+   YF    N+ + +ELC     + I       +EPE+R ++RQ  +GL+Y+HN GILHRD+K  N      +  +  ++ DFG++  ++  E  K +I  +  Y APE+ +       SDVWSLG   C M T        +  DL   +             +S     L++G+L+++P DRL  D++L+H F  G
Sbjct:   64 YSKGKLLGKGGFARCYEMTDLSSNKMYAVKVIPQSRVSKPHQREKITNEIELHRTLAHKHVVKFSHYFEDQENIYIFLELCSRKSLAHIWKARHTLTEPEVRYYLRQIISGLKYLHNRGILHRDLKLGNFFI---NENMDLRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTESDVWSLG---CVMYTLMCGSPPFETLDLKETYKCIKEVRYNLPSSLSPAAQKLISGILQKNPSDRLTLDQILNHEFFKG 318
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: ulk1a (serine/threonine-protein kinase ULK1 [Source:NCBI gene;Acc:101167046])

HSP 1 Score: 119.013 bits (297), Expect = 1.079e-29
Identity = 77/208 (37.02%), Postives = 116/208 (55.77%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRT-NVAVKVIYNYRLSQYQR---TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTH------KSRKLVYKISDFGISKMIDGTEKM--SIRASDIYSAPEINDYGEANFNSDVWSLGRTVCY 678
            M ++G + F++K+ +G G F +V++G + +  +  VAVK I    L++ Q     EI  LK L   NIVRLLDY  I G V L+ME C G D+   + + G   SE  IR F++Q A  ++ + + GILHRD+KP NIL  H       S     KI+DFG ++ +  T  M  ++  S +Y APE+      +  +D+WS+G T+ Y
Sbjct:    1 MESVGKFEFSRKDLIGHGAFAVVFKGRHKEKHSWEVAVKCINKKNLAKSQSLLGKEIKILKELKHGNIVRLLDYQEIGGCVYLVMEYCNGGDLAEYLHSKG-TLSEDTIRIFLQQIAQAMKVLQSKGILHRDLKPQNILLCHPEGRKSSSINASIKIADFGFARHLQ-TNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSIG-TIMY 205
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: si:ch73-60h1.1 (calcium/calmodulin-dependent protein kinase type IV [Source:NCBI gene;Acc:101155594])

HSP 1 Score: 114.39 bits (285), Expect = 1.982e-28
Identity = 86/266 (32.33%), Postives = 133/266 (50.00%), Query Frame = 1 
Query:  115 YFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEG-DMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKM-SIRASDIYSAPEI---NDYGEANFNSDVWSLG----------------RTVCYMITRDINDLDNYFVSS-------DLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNS 828
            ++   + LG+G   +VYR E  Q +   AVKV+      +  RTEI  L  L+  NI++L + F    ++ L++EL  G ++  RI   G  +SE +  + I+Q    + Y+H NG++HRD+KP N+L+   S     KI+DFG+SK+ID    M ++  +  Y APEI   N YG      D+WS+G                R   YM +R +N  D  FVS        +  DL+  ++  DP  RL   E L H ++ G+ +
Sbjct:   27 FYTLGSELGRGATSIVYRCEEKQTQKPYAVKVLKKTIDKKIVRTEIGVLLRLSHPNIIQLKEIFETDTDIALVLELVTGGELFDRIVERG-YYSERDAAHVIKQILEAVAYLHENGVVHRDLKPENLLYADLSLDASLKIADFGLSKIIDDQVTMKTVCGTPGYCAPEILRGNAYGP---EVDMWSVGVILYILLCGFEPFFDPRGDQYMYSRILN-CDYEFVSPWWDEVSLNAKDLVGKLIVLDPHKRLSVREALQHPWVLGKAA 287
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: plk2b (polo like kinase 2 [Source:NCBI gene;Acc:101166557])

HSP 1 Score: 110.153 bits (274), Expect = 9.014e-27
Identity = 73/260 (28.08%), Postives = 127/260 (48.85%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQRTEIDN----LKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITR-------DINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            + +   LG+GGF   Y   ++      A K+I + R+S+ +QR +ID      + LN R++V    +F    N+ +++E C     + I    +  +EPE+R ++RQ  +GL+Y+H   ILHRD+K  N  F  +S +L  K+ DFG++  ++  G  + +I  +  Y +PE+ +       SD+W+LG   C M T        +  +L   +             +S     L++ +L + P+DR   D +L H F T
Sbjct:   51 YCRGKVLGKGGFAKCYEMTDLSTSKVYAAKIIPHARVSKPHQREKIDREIELHRALNHRHVVHFYHHFEDKENIYILLEYCSRKSLAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGN-FFVSESMEL--KVGDFGLAAKLEPVGNRRKTICGTPNYLSPEVLNKQGHGCESDIWALG---CVMYTMLLGRPPFETTNLKETYKCIREARYSLPSSLSPQAKQLISSLLAKIPEDRPNLDHILRHDFFT 304
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: plk2b (polo like kinase 2 [Source:NCBI gene;Acc:101166557])

HSP 1 Score: 110.153 bits (274), Expect = 9.479e-27
Identity = 73/260 (28.08%), Postives = 127/260 (48.85%), Query Frame = 1 
Query:  118 FNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQ-YQRTEIDN----LKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID--GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITR-------DINDLDNYF-------------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFIT 816
            + +   LG+GGF   Y   ++      A K+I + R+S+ +QR +ID      + LN R++V    +F    N+ +++E C     + I    +  +EPE+R ++RQ  +GL+Y+H   ILHRD+K  N  F  +S +L  K+ DFG++  ++  G  + +I  +  Y +PE+ +       SD+W+LG   C M T        +  +L   +             +S     L++ +L + P+DR   D +L H F T
Sbjct:   51 YCRGKVLGKGGFAKCYEMTDLSTSKVYAAKIIPHARVSKPHQREKIDREIELHRALNHRHVVHFYHHFEDKENIYILLEYCSRKSLAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGN-FFVSESMEL--KVGDFGLAAKLEPVGNRRKTICGTPNYLSPEVLNKQGHGCESDIWALG---CVMYTMLLGRPPFETTNLKETYKCIREARYSLPSSLSPQAKQLISSLLAKIPEDRPNLDHILRHDFFT 304
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000012127.1 (SMESG000012127.1)

HSP 1 Score: 520.005 bits (1338), Expect = 0.000e+0
Identity = 253/253 (100.00%), Postives = 253/253 (100.00%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNFFNFLI 852
            MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNFFNFLI
Sbjct:    1 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNFFNFLI 253
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000012127.1 (SMESG000012127.1)

HSP 1 Score: 475.707 bits (1223), Expect = 2.823e-172
Identity = 232/232 (100.00%), Postives = 232/232 (100.00%), Query Frame = 1 
Query:  157 MVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNFFNFLI 852
            MVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNFFNFLI
Sbjct:    1 MVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNFFNFLI 232
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000012131.1 (SMESG000012131.1)

HSP 1 Score: 420.624 bits (1080), Expect = 6.811e-150
Identity = 212/272 (77.94%), Postives = 231/272 (84.93%), Query Frame = 1 
Query:   94 MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRDINDLDNYFVSSD---------------------LYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNFFNF 846
            MTTIG YYF+++NFLGQGGFG VYRG+NVQD TNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYF ITGNVILIM+LCEGDMESRIQNIGRQFSEPEIR+F++QTATGLRYIHNNGILHRDIKPANILFTH+S +LVYKISDFGISKMI+GTE+MSIRASDIYSAPEIN+YG ANFNSDVWSLGRTVCYM  RDIN ++NY VS D                     L+DLL  MLE+D + R  A +VLSH FITG NSLNFFNF
Sbjct:    1 MTTIGNYYFDQRNFLGQGGFGTVYRGKNVQDGTNVAVKVIYNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFIITGNVILIMKLCEGDMESRIQNIGRQFSEPEIRDFLQQTATGLRYIHNNGILHRDIKPANILFTHESWQLVYKISDFGISKMIEGTERMSIRASDIYSAPEINNYGVANFNSDVWSLGRTVCYMFFRDINKMNNYLVSLDSQKIFGRIFGHSACNYGIYLGLHDLLGRMLEKDHNRRFGAGDVLSHYFITGLNSLNFFNF 272
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000076532.1 (SMESG000076532.1)

HSP 1 Score: 115.161 bits (287), Expect = 1.685e-28
Identity = 73/250 (29.20%), Postives = 132/250 (52.80%), Query Frame = 1 
Query:  136 LGQGGFGMVYRGENVQDRTNVAVKVI-----YNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID-GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMI-------TRDINDLDNYF----------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 813
            LG+GGF  VYR ++ +    VA+K+I     +++ ++   R E++    L   +I+ L  +F     V L++E+C  G++  RI+  G   SE + R +++Q   GL+Y+H+  ILHRD+  AN+L T   + +  KI+DFG++  ++ G E  ++  +  Y +PE+    +    +DVWS+G  +  M+       T++I    N            +S    DL+ G+L+ +PD RL   ++ +H F+
Sbjct:   19 LGRGGFARVYRAKSQKTDQEVAIKIIDKKMMHHHGMTARVRKEVELHSRLKHPSILELYTFFEDANYVYLVLEMCHNGELHRRIRENG-PLSEDQARKYLKQIVDGLKYLHSYDILHRDLTLANLLLT---KDMKIKIADFGLATQLEAGVEHFTMCGTPNYISPEVVSRSKQGLEADVWSVGCMLYTMLVGKAPFDTKEIRGTLNRVQSGRFHLPSNISESSRDLIAGLLQTNPDKRLNLQQLSNHSFM 264
[Close]
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000076532.1 (SMESG000076532.1)

HSP 1 Score: 115.161 bits (287), Expect = 1.734e-28
Identity = 73/250 (29.20%), Postives = 132/250 (52.80%), Query Frame = 1 
Query:  136 LGQGGFGMVYRGENVQDRTNVAVKVI-----YNYRLSQYQRTEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCE-GDMESRIQNIGRQFSEPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFGISKMID-GTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMI-------TRDINDLDNYF----------VSSDLYDLLNGMLEEDPDDRLEADEVLSHCFI 813
            LG+GGF  VYR ++ +    VA+K+I     +++ ++   R E++    L   +I+ L  +F     V L++E+C  G++  RI+  G   SE + R +++Q   GL+Y+H+  ILHRD+  AN+L T   + +  KI+DFG++  ++ G E  ++  +  Y +PE+    +    +DVWS+G  +  M+       T++I    N            +S    DL+ G+L+ +PD RL   ++ +H F+
Sbjct:   20 LGRGGFARVYRAKSQKTDQEVAIKIIDKKMMHHHGMTARVRKEVELHSRLKHPSILELYTFFEDANYVYLVLEMCHNGELHRRIRENG-PLSEDQARKYLKQIVDGLKYLHSYDILHRDLTLANLLLT---KDMKIKIADFGLATQLEAGVEHFTMCGTPNYISPEVVSRSKQGLEADVWSVGCMLYTMLVGKAPFDTKEIRGTLNRVQSGRFHLPSNISESSRDLIAGLLQTNPDKRLNLQQLSNHSFM 265
The following BLAST results are available for this feature:
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PLK41.354e-3132.20polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11... [more]
PLK41.398e-3132.20polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11... [more]
PLK41.504e-3132.20polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11... [more]
PLK33.852e-2930.98polo like kinase 3 [Source:HGNC Symbol;Acc:HGNC:21... [more]
PLK42.498e-2830.74polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rskn-22.442e-2728.77Putative ribosomal protein S6 kinase alpha-2 [Sou... [more]
rskn-24.504e-2727.99Putative ribosomal protein S6 kinase alpha-2 [Sou... [more]
rskn-25.098e-2727.99Putative ribosomal protein S6 kinase alpha-2 [Sou... [more]
plk-16.676e-2730.95Serine/threonine-protein kinase plk-1 [Source:Uni... [more]
plk-12.466e-2530.28Serine/threonine-protein kinase plk-1 [Source:Uni... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Aduk5.497e-2828.29gene:FBgn0037679 transcript:FBtr0082056[more]
Aduk8.701e-2828.29gene:FBgn0037679 transcript:FBtr0082055[more]
Atg12.374e-2631.00gene:FBgn0260945 transcript:FBtr0075945[more]
Atg12.758e-2631.00gene:FBgn0260945 transcript:FBtr0300561[more]
SAK1.593e-2526.18gene:FBgn0026371 transcript:FBtr0078387[more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ulk1a1.981e-3135.71unc-51 like autophagy activating kinase 1a [Source... [more]
ulk1a1.126e-2935.71unc-51 like autophagy activating kinase 1a [Source... [more]
si:ch73-60h1.12.858e-2933.08si:ch73-60h1.1 [Source:ZFIN;Acc:ZDB-GENE-140106-15... [more]
plk34.760e-2931.15polo-like kinase 3 (Drosophila) [Source:ZFIN;Acc:Z... [more]
camk43.079e-2828.95calcium/calmodulin-dependent protein kinase IV [So... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
plk31.172e-3031.52polo-like kinase 3 [Source:NCBI gene;Acc:448451][more]
rtkn21.188e-3032.43rhotekin 2 [Source:Xenbase;Acc:XB-GENE-993318][more]
plk31.486e-3031.52polo-like kinase 3 [Source:NCBI gene;Acc:448451][more]
plk31.629e-3031.52polo-like kinase 3 [Source:NCBI gene;Acc:448451][more]
plk32.031e-3031.52polo-like kinase 3 [Source:NCBI gene;Acc:448451][more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Plk42.483e-3231.92polo like kinase 4 [Source:MGI Symbol;Acc:MGI:1017... [more]
Plk42.483e-3231.92polo like kinase 4 [Source:MGI Symbol;Acc:MGI:1017... [more]
Plk42.505e-3231.92polo like kinase 4 [Source:MGI Symbol;Acc:MGI:1017... [more]
Plk42.505e-3231.92polo like kinase 4 [Source:MGI Symbol;Acc:MGI:1017... [more]
Plk42.507e-3231.92polo like kinase 4 [Source:MGI Symbol;Acc:MGI:1017... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8T2I8|SEPA_DICDI3.588e-3333.21Serine/threonine-protein kinase sepA OS=Dictyostel... [more]
sp|Q64702|PLK4_MOUSE1.754e-3131.92Serine/threonine-protein kinase PLK4 OS=Mus muscul... [more]
sp|Q5R9Z7|PLK4_PONAB2.236e-3132.95Serine/threonine-protein kinase PLK4 OS=Pongo abel... [more]
sp|B2GUY1|PLK4_RAT2.906e-3131.92Serine/threonine-protein kinase PLK4 OS=Rattus nor... [more]
sp|O00444|PLK4_HUMAN7.223e-3132.20Serine/threonine-protein kinase PLK4 OS=Homo sapie... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
F6I0I41.241e-3132.16Protein kinase domain-containing protein OS=Vitis ... [more]
A0A137NX973.089e-3130.91Pkinase-domain-containing protein OS=Conidiobolus ... [more]
W4ZGD83.607e-3132.25Protein kinase domain-containing protein OS=Strong... [more]
F2UMG65.265e-3132.49PLK/SAK protein kinase OS=Salpingoeca rosetta (str... [more]
E4XMV06.217e-3131.52Protein kinase domain-containing protein OS=Oikopl... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
plk31.551e-2930.86polo like kinase 3 [Source:NCBI gene;Acc:103024965... [more]
ulk1b1.509e-2831.29unc-51 like autophagy activating kinase 1 [Source:... [more]
ulk1b1.590e-2831.29unc-51 like autophagy activating kinase 1 [Source:... [more]
ulk1a3.569e-2835.89unc-51 like autophagy activating kinase 1a [Source... [more]
si:ch73-60h1.11.229e-2732.82calcium/calmodulin-dependent protein kinase type I... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
STK366.123e-2829.02serine/threonine kinase 36 [Source:HGNC Symbol;Acc... [more]
ENSPMAT00000002824.18.939e-2629.29pep scaffold:Pmarinus_7.0:GL476598:1893846:1903215... [more]
plk31.347e-2427.63polo-like kinase 3 (Drosophila) [Source:ZFIN;Acc:Z... [more]
stk333.914e-2428.62serine/threonine kinase 33 [Source:ZFIN;Acc:ZDB-GE... [more]
mylk32.579e-2330.30myosin light chain kinase 3 [Source:NCBI gene;Acc:... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
CDC158.923e-2730.43Protein kinase of the Mitotic Exit Network; locali... [more]
BCK14.654e-2330.80MAPKKK acting in the protein kinase C signaling pa... [more]
CMK23.753e-2227.27Calmodulin-dependent protein kinase; may play a ro... [more]
CMK11.362e-2129.95Calmodulin-dependent protein kinase; may play a ro... [more]
CDC56.857e-2126.34Polo-like kinase; controls targeting and activatio... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO377992.004e-3431.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO413991.939e-2831.35Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO491381.343e-2731.35Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO354371.964e-2630.52Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO347074.889e-2629.50Serine/threonine-protein kinase PLK4 [Source:UniP... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
plk36.717e-3231.03polo like kinase 3 [Source:NCBI gene;Acc:101155385... [more]
ulk1a1.079e-2937.02serine/threonine-protein kinase ULK1 [Source:NCBI ... [more]
si:ch73-60h1.11.982e-2832.33calcium/calmodulin-dependent protein kinase type I... [more]
plk2b9.014e-2728.08polo like kinase 2 [Source:NCBI gene;Acc:101166557... [more]
plk2b9.479e-2728.08polo like kinase 2 [Source:NCBI gene;Acc:101166557... [more]
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BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000012127.10.000e+0100.00SMESG000012127.1[more]
SMESG000012127.12.823e-172100.00SMESG000012127.1[more]
SMESG000012131.16.811e-15077.94SMESG000012131.1[more]
SMESG000076532.11.685e-2829.20SMESG000076532.1[more]
SMESG000076532.11.734e-2829.20SMESG000076532.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008091 ID=SMED30008091|Name=Serine/threonine-protein kinase PLK|organism=Schmidtea mediterranea sexual|type=transcript|length=863bp
GCCAATCAAATTCAAAGTTGGAATTGGAATTAATTTTTACTTATTTATAC
AATTTATCTGACAAAAAAGTCATATGTTGTTTAACAGAAATCAATGACTA
CAATCGGCTATTACTATTTTAACAAAAAAAATTTTCTTGGACAAGGAGGA
TTTGGAATGGTCTATCGTGGTGAGAATGTTCAGGATAGAACAAATGTTGC
TGTAAAAGTTATTTACAATTATCGCTTGTCTCAATATCAAAGAACAGAAA
TTGATAATCTTAAAGGATTGAATTGCAGAAATATTGTCCGTCTATTGGAT
TACTTTACAATTACTGGGAATGTCATTTTGATTATGGAACTCTGTGAGGG
AGACATGGAAAGCAGGATTCAAAATATTGGAAGACAATTTTCAGAGCCTG
AAATTAGAAATTTTATTAGACAAACGGCAACGGGATTGAGATACATTCAT
AACAACGGAATTTTGCACAGGGATATCAAGCCGGCAAATATTCTATTTAC
GCACAAATCGAGGAAATTGGTTTATAAAATTTCGGATTTCGGCATATCAA
AAATGATTGACGGTACAGAAAAAATGAGTATCCGAGCATCAGATATTTAT
TCAGCTCCAGAAATAAATGATTATGGAGAGGCAAATTTCAATTCCGACGT
TTGGAGTTTGGGACGCACTGTTTGTTATATGATTACCCGAGATATAAACG
ACCTTGATAATTATTTCGTATCTTCGGATCTATATGACCTTCTTAATGGA
ATGCTAGAAGAGGATCCTGACGACAGACTAGAAGCAGATGAAGTTCTCAG
CCATTGCTTCATAACTGGACAGAACTCTTTGAATTTCTTTAACTTTTTAA
TTTAATATTTGTG
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protein sequence of SMED30008091-orf-1

>SMED30008091-orf-1 ID=SMED30008091-orf-1|Name=SMED30008091-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=254bp
MTTIGYYYFNKKNFLGQGGFGMVYRGENVQDRTNVAVKVIYNYRLSQYQR
TEIDNLKGLNCRNIVRLLDYFTITGNVILIMELCEGDMESRIQNIGRQFS
EPEIRNFIRQTATGLRYIHNNGILHRDIKPANILFTHKSRKLVYKISDFG
ISKMIDGTEKMSIRASDIYSAPEINDYGEANFNSDVWSLGRTVCYMITRD
INDLDNYFVSSDLYDLLNGMLEEDPDDRLEADEVLSHCFITGQNSLNFFN
FLI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
IPR013809ENTH
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0007099centriole replication
GO:0016310phosphorylation
GO:0046601positive regulation of centriole replication
GO:0098535de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
Vocabulary: cellular component
TermDefinition
GO:0005730nucleolus
GO:0005737cytoplasm
GO:0005814centriole
GO:0005856cytoskeleton
GO:0098536deuterosome
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 9..240
e-value: 2.0E-56
score: 203.4
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 9..199
e-value: 1.7E-47
score: 162.1
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 9..240
score: 38.421
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 3..250
e-value: 3.3E-62
score: 212.6
NoneNo IPR availablePANTHERPTHR24347SERINE/THREONINE-PROTEIN KINASEcoord: 7..246
NoneNo IPR availablePANTHERPTHR24347:SF412CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE Icoord: 7..246
NoneNo IPR availableCDDcd00180PKccoord: 15..237
e-value: 3.48778E-62
score: 192.485
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 15..38
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 123..135
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 8..244