Protein tyrosine kinase

Overview


Name	Protein tyrosine kinase
Smed ID	SMED30008072
Length (bp)	4526

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Protein tyrosine kinase (SMED30008072) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein tyrosine kinase (SMED30008072) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein tyrosine kinase (SMED30008072) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein tyrosine kinase (SMED30008072) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30008072

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
posterior side	SMED30008072	SMESG000064360.1	dd_Smed_v4_10115_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30008072	SMESG000064360.1	dd_Smed_v4_10115_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30008072	SMESG000077723.1	Contig4686	GPL15192	PMID:29674431 Fincher et al., 2018
epidermis	SMED30008072	SMESG000064360.1	dd_Smed_v4_10115_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Human
Match: TNK2 (tyrosine kinase non receptor 2 [Source:HGNC Symbol;Acc:HGNC:19297])

HSP 1 Score: 163.696 bits (413), Expect = 8.678e-42
Identity = 147/517 (28.43%), Postives = 226/517 (43.71%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIG--AIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD-------LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L +   +  +YV   DL  IGM RP  RRL +  ++   + A+ K K  +S+  S +      P   S      + R     P   P G   L ++  +                  +G K L L  +L  G   +++ GE+            S K VSV       LK D       +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:    6 GTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKALCKRKSWMSKVFSGKRLEAEFPPHHS----QSTFRKTSPAPG-GPAGEGPLQSLTCL------------------IGEKDLRLLEKLGDGSFGVVRRGEWD---------APSGKTVSVAVKC---LKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 441

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Human
Match: TNK2 (tyrosine kinase non receptor 2 [Source:HGNC Symbol;Acc:HGNC:19297])

HSP 1 Score: 164.851 bits (416), Expect = 2.354e-40
Identity = 145/517 (28.05%), Postives = 226/517 (43.71%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIG--AIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD-------LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L +   +  +YV   DL  IGM RP  RRL +  ++   + A+ K K  +S+  S +        +     +  + R     P   P G   L ++  +                  +G K L L  +L  G   +++ GE+            S K VSV       LK D       +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:    6 GTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKALCKRKSWMSKVFSGKRLEA----EFPPHHSQSTFRKTSPAPG-GPAGEGPLQSLTCL------------------IGEKDLRLLEKLGDGSFGVVRRGEWD---------APSGKTVSVAVKC---LKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 441

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Human
Match: TNK2 (tyrosine kinase non receptor 2 [Source:HGNC Symbol;Acc:HGNC:19297])

HSP 1 Score: 164.851 bits (416), Expect = 2.473e-40
Identity = 147/517 (28.43%), Postives = 226/517 (43.71%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIG--AIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD-------LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L +   +  +YV   DL  IGM RP  RRL +  ++   + A+ K K  +S+  S +      P   S      + R     P   P G   L ++  +                  +G K L L  +L  G   +++ GE+            S K VSV       LK D       +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:    6 GTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKALCKRKSWMSKVFSGKRLEAEFPPHHS----QSTFRKTSPAPG-GPAGEGPLQSLTCL------------------IGEKDLRLLEKLGDGSFGVVRRGEWD---------APSGKTVSVAVKC---LKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 441

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Human
Match: TNK2 (tyrosine kinase non receptor 2 [Source:HGNC Symbol;Acc:HGNC:19297])

HSP 1 Score: 164.851 bits (416), Expect = 2.489e-40
Identity = 147/517 (28.43%), Postives = 226/517 (43.71%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIG--AIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD-------LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L +   +  +YV   DL  IGM RP  RRL +  ++   + A+ K K  +S+  S +      P   S      + R     P   P G   L ++  +                  +G K L L  +L  G   +++ GE+            S K VSV       LK D       +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:   38 GTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKALCKRKSWMSKVFSGKRLEAEFPPHHS----QSTFRKTSPAPG-GPAGEGPLQSLTCL------------------IGEKDLRLLEKLGDGSFGVVRRGEWD---------APSGKTVSVAVKC---LKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 473

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Human
Match: TNK2 (tyrosine kinase non receptor 2 [Source:HGNC Symbol;Acc:HGNC:19297])

HSP 1 Score: 164.851 bits (416), Expect = 2.506e-40
Identity = 147/517 (28.43%), Postives = 226/517 (43.71%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIG--AIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD-------LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L +   +  +YV   DL  IGM RP  RRL +  ++   + A+ K K  +S+  S +      P   S      + R     P   P G   L ++  +                  +G K L L  +L  G   +++ GE+            S K VSV       LK D       +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:    6 GTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKALCKRKSWMSKVFSGKRLEAEFPPHHS----QSTFRKTSPAPG-GPAGEGPLQSLTCL------------------IGEKDLRLLEKLGDGSFGVVRRGEWD---------APSGKTVSVAVKC---LKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 441

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Celegans
Match: ark-1 (Ack-related non-receptor tyrosine kinase [Source:UniProtKB/Swiss-Prot;Acc:G5EBZ8])

HSP 1 Score: 241.891 bits (616), Expect = 3.895e-65
Identity = 170/588 (28.91%), Postives = 272/588 (46.26%), Query Frame = 3

Query:  189 LLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTS-NRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFR--IGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTD-TNDRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQ----SDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKD--FWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFG 1904
            L + L+ A L  Y  +L  KLK+R  A L+YV+E+DLLS+GM+RPE +RL+K + K FP    GK+KK   R+ S +R TS                                          S+A+    D          H+I   ++T+   +  GEF  ++ A ++   G    QV+VK +    L +  + F++E  +   + H +V++L+G+ LD + I LV+E     SLL+CL  P  + ++ +    ++  QI+  M+YLE +R+IH  L +RNVLV+    +KI+D GL RS  I E   R++ T + K    W APE IN  + T  SD+WA+GV +WEM+SYG+ P       G+Q     D K   L +P  C   ++ ++   W+ Q +DRPTF  + + F +   + + A+ D  D    H                     L++ + D ++V+ R+   Y D  +W G L NG+ G F+ ++             TV H+     S+ P ++           +   K K   +    ++ +       +IS P  D RH  HV  +G  FG
Sbjct:   14 LNKLLQAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRLRKEYTKMFPSGIFGKVKKAFKRAESLDRKTS-----------------------------------------NSVANQDDND---------HHVIPIEKITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEMPWKGRS--GAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKFPERRAQSVRAVVDCKDSAADH---------------------LHFKKDDLIVVISRSPAQYPDGYYWFGSLRNGKLGLFRPTD-------------TVAHL----GSEPPCSNGTIENGFSEKEKGGKKNKKAEKESERERKKL------LISEPVGDVRHTCHVGIDGTAFG 505

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Celegans
Match: ark-1 (Ack-related non-receptor tyrosine kinase [Source:UniProtKB/Swiss-Prot;Acc:G5EBZ8])

HSP 1 Score: 241.891 bits (616), Expect = 4.045e-65
Identity = 170/588 (28.91%), Postives = 272/588 (46.26%), Query Frame = 3

Query:  189 LLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTS-NRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFR--IGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTD-TNDRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQ----SDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKD--FWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFG 1904
            L + L+ A L  Y  +L  KLK+R  A L+YV+E+DLLS+GM+RPE +RL+K + K FP    GK+KK   R+ S +R TS                                          S+A+    D          H+I   ++T+   +  GEF  ++ A ++   G    QV+VK +    L +  + F++E  +   + H +V++L+G+ LD + I LV+E     SLL+CL  P  + ++ +    ++  QI+  M+YLE +R+IH  L +RNVLV+    +KI+D GL RS  I E   R++ T + K    W APE IN  + T  SD+WA+GV +WEM+SYG+ P       G+Q     D K   L +P  C   ++ ++   W+ Q +DRPTF  + + F +   + + A+ D  D    H                     L++ + D ++V+ R+   Y D  +W G L NG+ G F+ ++             TV H+     S+ P ++           +   K K   +    ++ +       +IS P  D RH  HV  +G  FG
Sbjct:   14 LNKLLQAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRLRKEYTKMFPSGIFGKVKKAFKRAESLDRKTS-----------------------------------------NSVANQDDND---------HHVIPIEKITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEMPWKGRS--GAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKFPERRAQSVRAVVDCKDSAADH---------------------LHFKKDDLIVVISRSPAQYPDGYYWFGSLRNGKLGLFRPTD-------------TVAHL----GSEPPCSNGTIENGFSEKEKGGKKNKKAEKESERERKKL------LISEPVGDVRHTCHVGIDGTAFG 505

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6])

HSP 1 Score: 135.576 bits (340), Expect = 8.989e-33
Identity = 77/258 (29.84%), Postives = 133/258 (51.55%), Query Frame = 3

Query:  615 LILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDR--KDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHYLFQ-PDLCSNMVFSIITSCWSEQPRDRPTFYQL 1379
            +I  N + +G  I HGEF D+    ++     ++V++K ++K H    L+  + E      L HPN++ L G+ LDD N+ ++TE +   +L+  L+    +          F + I + M YLE K+I+H  L +RNVL+  D   K++D GL +  +       + +    W APE +  SQ T  SD+W+FG+LLWE++S+G+ P            ++  Y  + P+ C   +F ++   W+   +DRP+F Q+
Sbjct:  277 VISSNDIDVGDTIGHGEFGDVRLGTYK----NRKVALK-VSKRHGNGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRS-RGRHALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQV 528

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Query:  615 LILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDR--KDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHYLFQ-PDLCSNMVFSIITSCWSEQPRDRPTFYQL 1379
            +I  N + +G  I HGEF D+    ++     ++V++K ++K H    L+  + E      L HPN++ L G+ LDD N+ ++TE +   +L+  L+    +          F + I + M YLE K+I+H  L +RNVL+  D   K++D GL +  +       + +    W APE +  SQ T  SD+W+FG+LLWE++S+G+ P            ++  Y  + P+ C   +F ++   W+   +DRP+F Q+
Sbjct:  277 VISSNDIDVGDTIGHGEFGDVRLGTYK----NRKVALK-VSKRHGNGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRS-RGRHALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQV 528

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BLAST of Protein tyrosine kinase vs. Ensembl Celegans
Match: csk-1 (Tyrosine-protein kinase csk-1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECJ6])

HSP 1 Score: 135.961 bits (341), Expect = 1.764e-32
Identity = 77/258 (29.84%), Postives = 133/258 (51.55%), Query Frame = 3

Query:  615 LILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDR--KDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHYLFQ-PDLCSNMVFSIITSCWSEQPRDRPTFYQL 1379
            +I  N + +G  I HGEF D+    ++     ++V++K ++K H    L+  + E      L HPN++ L G+ LDD N+ ++TE +   +L+  L+    +          F + I + M YLE K+I+H  L +RNVL+  D   K++D GL +  +       + +    W APE +  SQ T  SD+W+FG+LLWE++S+G+ P            ++  Y  + P+ C   +F ++   W+   +DRP+F Q+
Sbjct:  362 VISSNDIDVGDTIGHGEFGDVRLGTYK----NRKVALK-VSKRHGNGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRS-RGRHALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQV 613

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BLAST of Protein tyrosine kinase vs. Ensembl Fly
Match: Ack-like (gene:FBgn0263998 transcript:FBtr0330329)

HSP 1 Score: 281.567 bits (719), Expect = 7.475e-77
Identity = 183/592 (30.91%), Postives = 298/592 (50.34%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITY-SILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSLYTS 1928
            +L EFL E++L  Y++ +  +LKI   AQ KY  + DL  IG++RPE+RRL+K++EK FP + + KIK+ L        T V R +   G      V ++G              + AS  +   A NG +    +    +KH+I  + +++   +  GEF  +    +  G  + QV++K + +  ++S+  EF+KE  +   ++H N+++L+G+ L   ++ LVTE  ++ SLL+CL+D   ++++ +I T   F +QI   M YLE+KR+IH  L +RN+LV+  +++KI+D GL R+  + +   +T+ N        W APE IN  + T +SD+WAFGV LWEM+SYG  P   ++  + L +        L QPD C +  ++++  CW +    RP F ++      + PEQL A+ +  +    H                     L Y +GD + VLDRN      FWKG L  G++GYF  SN             TV  +  L +S                 ++F+++       SD +    ++  +MIS PQ DF+H GHV  +G  FGD+  L +S
Sbjct:    7 DLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAP----GTMVKREEAPGG---GSQVALDG--------------SSASACSSLAAKNGASSPSKVPN--NKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDH---------------------LLYRQGDIISVLDRNTG--TPFWKGVLSTGKTGYFNPSN-------------TVAFLEGLPSS---------------TRDSFSRV-------SDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSS 517

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Fly
Match: Ack-like (gene:FBgn0263998 transcript:FBtr0330331)

HSP 1 Score: 281.567 bits (719), Expect = 7.924e-77
Identity = 183/592 (30.91%), Postives = 298/592 (50.34%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITY-SILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSLYTS 1928
            +L EFL E++L  Y++ +  +LKI   AQ KY  + DL  IG++RPE+RRL+K++EK FP + + KIK+ L        T V R +   G      V ++G              + AS  +   A NG +    +    +KH+I  + +++   +  GEF  +    +  G  + QV++K + +  ++S+  EF+KE  +   ++H N+++L+G+ L   ++ LVTE  ++ SLL+CL+D   ++++ +I T   F +QI   M YLE+KR+IH  L +RN+LV+  +++KI+D GL R+  + +   +T+ N        W APE IN  + T +SD+WAFGV LWEM+SYG  P   ++  + L +        L QPD C +  ++++  CW +    RP F ++      + PEQL A+ +  +    H                     L Y +GD + VLDRN      FWKG L  G++GYF  SN             TV  +  L +S                 ++F+++       SD +    ++  +MIS PQ DF+H GHV  +G  FGD+  L +S
Sbjct:    7 DLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAP----GTMVKREEAPGG---GSQVALDG--------------SSASACSSLAAKNGASSPSKVPN--NKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDH---------------------LLYRQGDIISVLDRNTG--TPFWKGVLSTGKTGYFNPSN-------------TVAFLEGLPSS---------------TRDSFSRV-------SDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSS 517

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Fly
Match: Ack-like (gene:FBgn0263998 transcript:FBtr0330330)

HSP 1 Score: 280.411 bits (716), Expect = 2.982e-76
Identity = 183/592 (30.91%), Postives = 298/592 (50.34%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITY-SILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSLYTS 1928
            +L EFL E++L  Y++ +  +LKI   AQ KY  + DL  IG++RPE+RRL+K++EK FP + + KIK+ L        T V R +   G      V ++G              + AS  +   A NG +    +    +KH+I  + +++   +  GEF  +    +  G  + QV++K + +  ++S+  EF+KE  +   ++H N+++L+G+ L   ++ LVTE  ++ SLL+CL+D   ++++ +I T   F +QI   M YLE+KR+IH  L +RN+LV+  +++KI+D GL R+  + +   +T+ N        W APE IN  + T +SD+WAFGV LWEM+SYG  P   ++  + L +        L QPD C +  ++++  CW +    RP F ++      + PEQL A+ +  +    H                     L Y +GD + VLDRN      FWKG L  G++GYF  SN             TV  +  L +S                 ++F+++       SD +    ++  +MIS PQ DF+H GHV  +G  FGD+  L +S
Sbjct:    7 DLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAP----GTMVKREEAPGG---GSQVALDG--------------SSASACSSLAAKNGASSPSKVPN--NKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDH---------------------LLYRQGDIISVLDRNTGT--PFWKGVLSTGKTGYFNPSN-------------TVAFLEGLPSS---------------TRDSFSRV-------SDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSS 517

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Fly
Match: Ack-like (gene:FBgn0263998 transcript:FBtr0330332)

HSP 1 Score: 280.411 bits (716), Expect = 3.336e-76
Identity = 183/595 (30.76%), Postives = 301/595 (50.59%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITY-SILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP------ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSLYTS 1928
            +L EFL E++L  Y++ +  +LKI   AQ KY  + DL  IG++RPE+RRL+K++EK FP + + KIK+ L        T V R +   G      V ++G              + AS  +   A NG +    +    +KH+I  + +++   +  GEF  +    +  G  + QV++K + +  ++S+  EF+KE  +   ++H N+++L+G+ L   ++ LVTE  ++ SLL+CL+D   ++++ +I T   F +QI   M YLE+KR+IH  L +RN+LV+  +++KI+D GL R+  + +   +T+ N        W APE IN  + T +SD+WAFGV LWEM+SYG  P      + + E++ + +  +L    QPD C +  ++++  CW +    RP F ++      + PEQL A+ +  +    H                     L Y +GD + VLDRN      FWKG L  G++GYF  SN             TV  +  L +S                 ++F+++       SD +    ++  +MIS PQ DF+H GHV  +G  FGD+  L +S
Sbjct:    7 DLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAP----GTMVKREEAPGG---GSQVALDG--------------SSASACSSLAAKNGASSPSKVPN--NKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLE---QPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDH---------------------LLYRQGDIISVLDRNTGT--PFWKGVLSTGKTGYFNPSN-------------TVAFLEGLPSS---------------TRDSFSRV-------SDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSS 517

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Fly
Match: Ack (gene:FBgn0028484 transcript:FBtr0073211)

HSP 1 Score: 153.68 bits (387), Expect = 3.569e-37
Identity = 125/428 (29.21%), Postives = 196/428 (45.79%), Query Frame = 3

Query:  189 LLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD-------LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTD-----TNDRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIA 1421
            L + L+E QL+ + D +   L++   A   YV   DL   G+ +P +RRL            M  ++KK +                  R N  S  + G     S          +S    S   NGT       QL    LI +  +T+G  +  G F  +    +    + K + V    KV LKSD       +++F +E+     LDH N+++L+G+ L  Q + ++TE     SLL  L+      + +I+   N+++QI   M YLE+KR +H  L  RNVL+   N+IKI D GL R+   L + D     +  +K    W APE +   Q + +SD W FGV LWEM+S+G+ P + ++ S +  + D +   L QPD C   V++++  CW + P +RPTF  L      + P  + A
Sbjct:   18 LEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRL------------MEAVRKKKAHQW---------------RKNILSKLIGGGKQPSS-------KKQSSAARESSQGNGT-------QLTC--LIHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAV--KV-LKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVLS-QPMMMITELAERGSLLDTLRKQCRHTSLTII--WNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRA---LPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPPVMRA 393

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Zebrafish
Match: tnk2b (tyrosine kinase, non-receptor, 2b [Source:ZFIN;Acc:ZDB-GENE-110411-165])

HSP 1 Score: 164.851 bits (416), Expect = 1.762e-40
Identity = 147/523 (28.11%), Postives = 239/523 (45.70%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSV---PRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFI--NKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNL 1697
            G + LLE L E QL  YF  +  +L I   +   YV   DL  IGM RP  RRL +  ++   +  M K K  +S+  S +       P+P     +L+     ++G            LT + S  + ++            +LG              ++K GE+   +  N ++      V+VK +  + ++    L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + S+L  L+   +   + I T   +TIQIS  M YLE KR IH  L +RN+L+    Q+KI D GL R+   L + D +      RK    W APE +     + ++D W FGV LWEM++YGQ P   ++ S+ L  + D +   L +P+ C   +++++  CW+++P DRPTF  L     + +P  + AL            +DF+EP         ++QM      D + +++     Y  +W+G             N R++ V   P N TV  +  L
Sbjct:   32 GTEWLLELLMEVQLQQYFLRIRDELNITRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKR---RKTMCKRKSWMSKVFSGKRPEGDFNPQPASTFRKLSPTPPLVDGQ--------QQALTCLISEKDLAL----------FEKLGDGSF---------GVVKRGEW---FTPNGKV----LNVAVKCLKTDVLNQPDALDDFIREVNAMHSLDHQNLIRLYGVVLT-HPMKMVTELAPLGSMLDRLR--KTLGHFLISTLCQYTIQISNGMGYLESKRFIHRDLAARNILLASSEQVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMFTYGQEPWLGLNGSQIL-HKIDKEGERLPKPEDCPQDLYNVMMQCWAQKPDDRPTFVALREFLVETMPTDMRAL------------QDFDEPDK------LQIQM-----DDVITIIEGRAENY--WWRG------------QNKRTLKVGQFPRN-TVTSVAGL 472

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Zebrafish
Match: tnk2a (tyrosine kinase, non-receptor, 2a [Source:ZFIN;Acc:ZDB-GENE-091118-85])

HSP 1 Score: 156.762 bits (395), Expect = 4.211e-38
Identity = 132/442 (29.86%), Postives = 210/442 (47.51%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRS-TSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLK--SDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRS-------YSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALT--DGPDQIPSH 1454
            G + LLE L + QL  YF  +  +L +   +   YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  T  R  S  +  ++    +  S   +G           DLT + S                      + L L  +L  G+  ++K GE+      + R+      V+VK +    L     L++FI+E+     L+H N+I+L+G  L    +K+VTE   + SLL  L+     I  S+L   ++T+QI+  M YLE +R IH  L +RN+L+  ++ IKI D GL R+       Y + E         W APE +     + +SD W FGV LWEM+++GQ P + ++ S +  + D +   L +P+ C   +++++  CWS +P DRPTF  L     + +P  + AL   D PD++  H
Sbjct:    6 GTEWLLELLTDVQLQQYFQRIRDELNVTRLSHFDYVKTEDLEKIGMGRPGQRRLWEAVKR---RRAMCKRKSWMSKVFTGKRPDSDSQTPEVFRSSSPSSAPPDGQ--------PTDLTCLIS---------------------ERDLTLYEKLGDGSFGVVKRGEWQ---APSGRV----LSVAVKCLKTDLLDQGEGLDDFIREVNAMHSLNHHNLIRLYGCVL-THPMKMVTELAPLGSLLDRLRKRQGHILISVLC--HYTVQIACGMAYLESRRFIHRDLAARNILLASNDLIKIGDFGLMRALPKNDDHYVMQEHHKVP--FAWCAPESLKTRTFSHASDTWMFGVTLWEMFTHGQEPWVGLNGSQILHKIDREGERLIKPEDCPQDIYNVMLQCWSPKPEDRPTFVSLRDFLVETMPTDMRALQDFDEPDKLKIH 403

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Zebrafish
Match: tnk2a (tyrosine kinase, non-receptor, 2a [Source:ZFIN;Acc:ZDB-GENE-091118-85])

HSP 1 Score: 155.992 bits (393), Expect = 1.029e-37
Identity = 133/449 (29.62%), Postives = 211/449 (46.99%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRS--------TSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLK--SDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRS-------YSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALT--DGPDQIPSH 1454
            G + LLE L + QL  YF  +  +L +   +   YV   DL  IGM RP  RRL +  ++   + AM K K  +S+S        T  R  S  +  ++    +  S   +G           DLT + S                      + L L  +L  G+  ++K GE+      + R+      V+VK +    L     L++FI+E+     L+H N+I+L+G  L    +K+VTE   + SLL  L+     I  S+L   ++T+QI+  M YLE +R IH  L +RN+L+  ++ IKI D GL R+       Y + E         W APE +     + +SD W FGV LWEM+++GQ P + ++ S +  + D +   L +P+ C   +++++  CWS +P DRPTF  L     + +P  + AL   D PD++  H
Sbjct:   24 GTEWLLELLTDVQLQQYFQRIRDELNVTRLSHFDYVKTEDLEKIGMGRPGQRRLWEAVKR---RRAMCKRKSWMSKSLCLGQQVFTGKRPDSDSQTPEVFRSSSPSSAPPDGQ--------PTDLTCLIS---------------------ERDLTLYEKLGDGSFGVVKRGEWQ---APSGRV----LSVAVKCLKTDLLDQGEGLDDFIREVNAMHSLNHHNLIRLYGCVL-THPMKMVTELAPLGSLLDRLRKRQGHILISVLC--HYTVQIACGMAYLESRRFIHRDLAARNILLASNDLIKIGDFGLMRALPKNDDHYVMQEHHKVP--FAWCAPESLKTRTFSHASDTWMFGVTLWEMFTHGQEPWVGLNGSQILHKIDREGERLIKPEDCPQDIYNVMLQCWSPKPEDRPTFVSLRDFLVETMPTDMRALQDFDEPDKLKIH 428

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Zebrafish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-070705-183])

HSP 1 Score: 148.673 bits (374), Expect = 1.530e-37
Identity = 89/275 (32.36%), Postives = 148/275 (53.82%), Query Frame = 3

Query:  582 SYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDL--NEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPI-SMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNK 1397
            S + + L S  L+  ++LT+G II  GEF  ++   +    + ++V+VK I     K D+    F++E  V   L H N++ L G+ L +  + +VTE +   +L+  L+    +   S++    F + + E M +LE K+++H  L  RN+LV  D   KI+D GL R  S+         K W APE +   + +  SD+W++GVLLWE++SYG+ P   M+ +   +   K + +  PD C   V+SI+TSCW  +P+ RP+F++L     K
Sbjct:  173 SAETKLLKSGWLLDLSKLTLGEIIGEGEFGAVFAGEY----TGQRVAVKII-----KCDVTAQAFLEETSVMTNLHHKNLVPLLGVILHN-GLHIVTELMTKGNLVNFLRS-RGRFAVSVIQLLRFALDVCEGMEHLESKKLLHRDLAGRNILVSEDGVAKISDFGLARVGSMAVDNSKLPVK-WTAPEALKNKKFSTQSDVWSYGVLLWEIFSYGRQPYPKMTVNEVKECVEKGYRMDPPDECPADVYSIMTSCWQTEPKKRPSFHKLRERLEK 435

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Zebrafish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-070705-183])

HSP 1 Score: 148.288 bits (373), Expect = 2.225e-37
Identity = 89/275 (32.36%), Postives = 148/275 (53.82%), Query Frame = 3

Query:  582 SYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDL--NEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPI-SMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNK 1397
            S + + L S  L+  ++LT+G II  GEF  ++   +    + ++V+VK I     K D+    F++E  V   L H N++ L G+ L +  + +VTE +   +L+  L+    +   S++    F + + E M +LE K+++H  L  RN+LV  D   KI+D GL R  S+         K W APE +   + +  SD+W++GVLLWE++SYG+ P   M+ +   +   K + +  PD C   V+SI+TSCW  +P+ RP+F++L     K
Sbjct:  176 SAETKLLKSGWLLDLSKLTLGEIIGEGEFGAVFAGEY----TGQRVAVKII-----KCDVTAQAFLEETSVMTNLHHKNLVPLLGVILHN-GLHIVTELMTKGNLVNFLRS-RGRFAVSVIQLLRFALDVCEGMEHLESKKLLHRDLAGRNILVSEDGVAKISDFGLARVGSMAVDNSKLPVK-WTAPEALKNKKFSTQSDVWSYGVLLWEIFSYGRQPYPKMTVNEVKECVEKGYRMDPPDECPADVYSIMTSCWQTEPKKRPSFHKLRERLEK 438

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Xenopus
Match: arfgef3 (ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE-6050101])

HSP 1 Score: 159.458 bits (402), Expect = 1.081e-38
Identity = 135/438 (30.82%), Postives = 210/438 (47.95%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPI-GSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFIN-KVHLKSD-LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD--GPDQI 1445
            G + LLE L E QL  YF ++   L I   +   YV   DL  IGM RP  RRL    ++   + A+ K K  +S+  S +     RP+         + R     PS  P+ G   LT + S  + S+            +LG              +++ GE+       F        V+VK +   V  + D L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+   ++  + I T  ++ IQI+  M YLE KR IH  L +RN+L+  ++ +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+     +++++  CW+ +P DRPTF  L     +  P  + AL D   PD++
Sbjct:   32 GSEWLLELLSEVQLQQYFLQIRDDLNITRLSHFDYVKNEDLEKIGMGRPGQRRLLDAVKR---RKAICKRKSWMSKVFSGK-----RPESEFASQPQSTFR---KPPSPPPLEGQQALTCLISEKDLSM----------FEKLGDGSF---------GVVRRGEWNTPNGKLF-------NVAVKCLKTDVLTQPDVLDDFIREVNAMHSLDHINLIRLYGVVL-THPMKMVTELAPMGSLLDRLR--KNQGYFLISTLCHYAIQIANGMAYLESKRFIHRDLAARNILLSSNDLVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLVRPEDSPQDIYNVMLQCWAHKPEDRPTFVALRDFLVEAQPTDMCALQDFQDPDKL 426

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Xenopus
Match: arfgef3 (ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE-6050101])

HSP 1 Score: 159.458 bits (402), Expect = 1.123e-38
Identity = 135/438 (30.82%), Postives = 210/438 (47.95%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPI-GSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFIN-KVHLKSD-LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD--GPDQI 1445
            G + LLE L E QL  YF ++   L I   +   YV   DL  IGM RP  RRL    ++   + A+ K K  +S+  S +     RP+         + R     PS  P+ G   LT + S  + S+            +LG              +++ GE+       F        V+VK +   V  + D L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+   ++  + I T  ++ IQI+  M YLE KR IH  L +RN+L+  ++ +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+     +++++  CW+ +P DRPTF  L     +  P  + AL D   PD++
Sbjct:   34 GSEWLLELLSEVQLQQYFLQIRDDLNITRLSHFDYVKNEDLEKIGMGRPGQRRLLDAVKR---RKAICKRKSWMSKVFSGK-----RPESEFASQPQSTFR---KPPSPPPLEGQQALTCLISEKDLSM----------FEKLGDGSF---------GVVRRGEWNTPNGKLF-------NVAVKCLKTDVLTQPDVLDDFIREVNAMHSLDHINLIRLYGVVL-THPMKMVTELAPMGSLLDRLR--KNQGYFLISTLCHYAIQIANGMAYLESKRFIHRDLAARNILLSSNDLVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLVRPEDSPQDIYNVMLQCWAHKPEDRPTFVALRDFLVEAQPTDMCALQDFQDPDKL 428

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Xenopus
Match: arfgef3 (ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE-6050101])

HSP 1 Score: 159.073 bits (401), Expect = 1.579e-38
Identity = 135/438 (30.82%), Postives = 210/438 (47.95%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPI-GSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFIN-KVHLKSD-LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD--GPDQI 1445
            G + LLE L E QL  YF ++   L I   +   YV   DL  IGM RP  RRL    ++   + A+ K K  +S+  S +     RP+         + R     PS  P+ G   LT + S  + S+            +LG              +++ GE+       F        V+VK +   V  + D L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+   ++  + I T  ++ IQI+  M YLE KR IH  L +RN+L+  ++ +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+     +++++  CW+ +P DRPTF  L     +  P  + AL D   PD++
Sbjct:    6 GSEWLLELLSEVQLQQYFLQIRDDLNITRLSHFDYVKNEDLEKIGMGRPGQRRLLDAVKR---RKAICKRKSWMSKVFSGK-----RPESEFASQPQSTFR---KPPSPPPLEGQQALTCLISEKDLSM----------FEKLGDGSF---------GVVRRGEWNTPNGKLF-------NVAVKCLKTDVLTQPDVLDDFIREVNAMHSLDHINLIRLYGVVL-THPMKMVTELAPMGSLLDRLR--KNQGYFLISTLCHYAIQIANGMAYLESKRFIHRDLAARNILLSSNDLVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLVRPEDSPQDIYNVMLQCWAHKPEDRPTFVALRDFLVEAQPTDMCALQDFQDPDKL 400

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Xenopus
Match: arfgef3 (ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE-6050101])

HSP 1 Score: 158.688 bits (400), Expect = 1.617e-38
Identity = 135/438 (30.82%), Postives = 210/438 (47.95%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPI-GSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFIN-KVHLKSD-LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD--GPDQI 1445
            G + LLE L E QL  YF ++   L I   +   YV   DL  IGM RP  RRL    ++   + A+ K K  +S+  S +     RP+         + R     PS  P+ G   LT + S  + S+            +LG              +++ GE+       F        V+VK +   V  + D L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+   ++  + I T  ++ IQI+  M YLE KR IH  L +RN+L+  ++ +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+     +++++  CW+ +P DRPTF  L     +  P  + AL D   PD++
Sbjct:    6 GSEWLLELLSEVQLQQYFLQIRDDLNITRLSHFDYVKNEDLEKIGMGRPGQRRLLDAVKR---RKAICKRKSWMSKVFSGK-----RPESEFASQPQSTFR---KPPSPPPLEGQQALTCLISEKDLSM----------FEKLGDGSF---------GVVRRGEWNTPNGKLF-------NVAVKCLKTDVLTQPDVLDDFIREVNAMHSLDHINLIRLYGVVL-THPMKMVTELAPMGSLLDRLR--KNQGYFLISTLCHYAIQIANGMAYLESKRFIHRDLAARNILLSSNDLVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLVRPEDSPQDIYNVMLQCWAHKPEDRPTFVALRDFLVEAQPTDMCALQDFQDPDKL 400

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Xenopus
Match: arfgef3 (ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE-6050101])

HSP 1 Score: 158.688 bits (400), Expect = 1.713e-38
Identity = 135/438 (30.82%), Postives = 210/438 (47.95%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPI-GSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFIN-KVHLKSD-LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD--GPDQI 1445
            G + LLE L E QL  YF ++   L I   +   YV   DL  IGM RP  RRL    ++   + A+ K K  +S+  S +     RP+         + R     PS  P+ G   LT + S  + S+            +LG              +++ GE+       F        V+VK +   V  + D L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+   ++  + I T  ++ IQI+  M YLE KR IH  L +RN+L+  ++ +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+     +++++  CW+ +P DRPTF  L     +  P  + AL D   PD++
Sbjct:    6 GSEWLLELLSEVQLQQYFLQIRDDLNITRLSHFDYVKNEDLEKIGMGRPGQRRLLDAVKR---RKAICKRKSWMSKVFSGK-----RPESEFASQPQSTFR---KPPSPPPLEGQQALTCLISEKDLSM----------FEKLGDGSF---------GVVRRGEWNTPNGKLF-------NVAVKCLKTDVLTQPDVLDDFIREVNAMHSLDHINLIRLYGVVL-THPMKMVTELAPMGSLLDRLR--KNQGYFLISTLCHYAIQIANGMAYLESKRFIHRDLAARNILLSSNDLVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLVRPEDSPQDIYNVMLQCWAHKPEDRPTFVALRDFLVEAQPTDMCALQDFQDPDKL 400

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Mouse
Match: Tnk2 (tyrosine kinase, non-receptor, 2 [Source:MGI Symbol;Acc:MGI:1858308])

HSP 1 Score: 169.859 bits (429), Expect = 4.741e-42
Identity = 149/512 (29.10%), Postives = 231/512 (45.12%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L I   +  +YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +                   R+    PS+    S       S T  S+   GT  S     +G K L L  +L  G+  +++ GE+      +   G++   V+VK +    L     +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:   30 GTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGK-------------------RLEAEFPSQH---SQSTFRKPSPTPGSLPGEGTLQSLTC-LIGEKDLRLLEKLGDGSFGVVRRGEW------DAPAGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLT-LPMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 465

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Mouse
Match: Tnk2 (tyrosine kinase, non-receptor, 2 [Source:MGI Symbol;Acc:MGI:1858308])

HSP 1 Score: 169.474 bits (428), Expect = 5.111e-42
Identity = 149/512 (29.10%), Postives = 231/512 (45.12%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L I   +  +YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +                   R+    PS+    S       S T  S+   GT  S     +G K L L  +L  G+  +++ GE+      +   G++   V+VK +    L     +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:    6 GTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGK-------------------RLEAEFPSQH---SQSTFRKPSPTPGSLPGEGTLQSLTC-LIGEKDLRLLEKLGDGSFGVVRRGEW------DAPAGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLT-LPMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 441

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Mouse
Match: Tnk2 (tyrosine kinase, non-receptor, 2 [Source:MGI Symbol;Acc:MGI:1858308])

HSP 1 Score: 169.474 bits (428), Expect = 5.346e-42
Identity = 149/512 (29.10%), Postives = 231/512 (45.12%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L I   +  +YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +                   R+    PS+    S       S T  S+   GT  S     +G K L L  +L  G+  +++ GE+      +   G++   V+VK +    L     +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:   38 GTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGK-------------------RLEAEFPSQH---SQSTFRKPSPTPGSLPGEGTLQSLTC-LIGEKDLRLLEKLGDGSFGVVRRGEW------DAPAGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLT-LPMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 473

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Mouse
Match: Tnk2 (tyrosine kinase, non-receptor, 2 [Source:MGI Symbol;Acc:MGI:1858308])

HSP 1 Score: 169.859 bits (429), Expect = 5.439e-42
Identity = 149/512 (29.10%), Postives = 231/512 (45.12%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L I   +  +YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +                   R+    PS+    S       S T  S+   GT  S     +G K L L  +L  G+  +++ GE+      +   G++   V+VK +    L     +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:   38 GTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGK-------------------RLEAEFPSQH---SQSTFRKPSPTPGSLPGEGTLQSLTC-LIGEKDLRLLEKLGDGSFGVVRRGEW------DAPAGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLT-LPMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 473

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Mouse
Match: Tnk2 (tyrosine kinase, non-receptor, 2 [Source:MGI Symbol;Acc:MGI:1858308])

HSP 1 Score: 169.474 bits (428), Expect = 5.550e-42
Identity = 149/512 (29.10%), Postives = 231/512 (45.12%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L I   +  +YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +                   R+    PS+    S       S T  S+   GT  S     +G K L L  +L  G+  +++ GE+      +   G++   V+VK +    L     +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:    6 GTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGK-------------------RLEAEFPSQH---SQSTFRKPSPTPGSLPGEGTLQSLTC-LIGEKDLRLLEKLGDGSFGVVRRGEW------DAPAGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLT-LPMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 441

[Close]

BLAST of Protein tyrosine kinase vs. UniProt/SwissProt
Match: sp|Q9I7F7|ACKL_DROME (Activated Cdc42 kinase-like OS=Drosophila melanogaster OX=7227 GN=Ack-like PE=1 SV=3)

HSP 1 Score: 281.567 bits (719), Expect = 7.493e-76
Identity = 183/592 (30.91%), Postives = 298/592 (50.34%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITY-SILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSLYTS 1928
            +L EFL E++L  Y++ +  +LKI   AQ KY  + DL  IG++RPE+RRL+K++EK FP + + KIK+ L        T V R +   G      V ++G              + AS  +   A NG +    +    +KH+I  + +++   +  GEF  +    +  G  + QV++K + +  ++S+  EF+KE  +   ++H N+++L+G+ L   ++ LVTE  ++ SLL+CL+D   ++++ +I T   F +QI   M YLE+KR+IH  L +RN+LV+  +++KI+D GL R+  + +   +T+ N        W APE IN  + T +SD+WAFGV LWEM+SYG  P   ++  + L +        L QPD C +  ++++  CW +    RP F ++      + PEQL A+ +  +    H                     L Y +GD + VLDRN      FWKG L  G++GYF  SN             TV  +  L +S                 ++F+++       SD +    ++  +MIS PQ DF+H GHV  +G  FGD+  L +S
Sbjct:    7 DLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAP----GTMVKREEAPGG---GSQVALDG--------------SSASACSSLAAKNGASSPSKVPN--NKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDH---------------------LLYRQGDIISVLDRNTG--TPFWKGVLSTGKTGYFNPSN-------------TVAFLEGLPSS---------------TRDSFSRV-------SDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSS 517

[Close]

BLAST of Protein tyrosine kinase vs. UniProt/SwissProt
Match: sp|G5EBZ8|ARK1_CAEEL (Ack-related non-receptor tyrosine kinase OS=Caenorhabditis elegans OX=6239 GN=ark-1 PE=2 SV=1)

HSP 1 Score: 241.891 bits (616), Expect = 4.954e-64
Identity = 170/588 (28.91%), Postives = 272/588 (46.26%), Query Frame = 3

Query:  189 LLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTS-NRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFR--IGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTD-TNDRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQ----SDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKD--FWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFG 1904
            L + L+ A L  Y  +L  KLK+R  A L+YV+E+DLLS+GM+RPE +RL+K + K FP    GK+KK   R+ S +R TS                                          S+A+    D          H+I   ++T+   +  GEF  ++ A ++   G    QV+VK +    L +  + F++E  +   + H +V++L+G+ LD + I LV+E     SLL+CL  P  + ++ +    ++  QI+  M+YLE +R+IH  L +RNVLV+    +KI+D GL RS  I E   R++ T + K    W APE IN  + T  SD+WA+GV +WEM+SYG+ P       G+Q     D K   L +P  C   ++ ++   W+ Q +DRPTF  + + F +   + + A+ D  D    H                     L++ + D ++V+ R+   Y D  +W G L NG+ G F+ ++             TV H+     S+ P ++           +   K K   +    ++ +       +IS P  D RH  HV  +G  FG
Sbjct:   14 LNKLLQAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRLRKEYTKMFPSGIFGKVKKAFKRAESLDRKTS-----------------------------------------NSVANQDDND---------HHVIPIEKITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEMPWKGRS--GAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKFPERRAQSVRAVVDCKDSAADH---------------------LHFKKDDLIVVISRSPAQYPDGYYWFGSLRNGKLGLFRPTD-------------TVAHL----GSEPPCSNGTIENGFSEKEKGGKKNKKAEKESERERKKL------LISEPVGDVRHTCHVGIDGTAFG 505

[Close]

BLAST of Protein tyrosine kinase vs. UniProt/SwissProt
Match: sp|O54967|ACK1_MOUSE (Activated CDC42 kinase 1 OS=Mus musculus OX=10090 GN=Tnk2 PE=1 SV=2)

HSP 1 Score: 169.474 bits (428), Expect = 3.984e-41
Identity = 149/512 (29.10%), Postives = 231/512 (45.12%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L I   +  +YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +                   R+    PS+    S       S T  S+   GT  S     +G K L L  +L  G+  +++ GE+      +   G++   V+VK +    L     +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:    6 GTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGK-------------------RLEAEFPSQH---SQSTFRKPSPTPGSLPGEGTLQSLTC-LIGEKDLRLLEKLGDGSFGVVRRGEW------DAPAGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLT-LPMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 441

[Close]

BLAST of Protein tyrosine kinase vs. UniProt/SwissProt
Match: sp|Q5U2X5|ACK1_RAT (Activated CDC42 kinase 1 OS=Rattus norvegicus OX=10116 GN=Tnk2 PE=2 SV=1)

HSP 1 Score: 169.088 bits (427), Expect = 5.512e-41
Identity = 148/512 (28.91%), Postives = 231/512 (45.12%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L I   +  +YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +      P        S   +     PS +P G     T+ S+T                 +G K L L  +L  G+  +++ GE+      +   G++   V+VK +    L     +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:    6 GTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGKRQEAEFP--------SHHSQSTFRKPSPTPGGLAGEGTLQSLTCL---------------IGEKDLRLLEKLGDGSFGVVRRGEW------DAPAGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDGHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 441

[Close]

BLAST of Protein tyrosine kinase vs. UniProt/SwissProt
Match: sp|Q07912|ACK1_HUMAN (Activated CDC42 kinase 1 OS=Homo sapiens OX=9606 GN=TNK2 PE=1 SV=3)

HSP 1 Score: 164.851 bits (416), Expect = 1.188e-39
Identity = 147/517 (28.43%), Postives = 226/517 (43.71%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIG--AIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD-------LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMSES-LGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMN 1670
            G   LLE L E QL  YF  L   L +   +  +YV   DL  IGM RP  RRL +  ++   + A+ K K  +S+  S +      P   S      + R     P   P G   L ++  +                  +G K L L  +L  G   +++ GE+            S K VSV       LK D       +++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+    +  + + T   + +Q++E M YLE KR IH  L +RN+L+   + +KI D GL R+   L + D +      RK    W APE +     + +SD W FGV LWEM++YGQ P I ++ S +  + D +   L +P+ C   +++++  CW+ +P DRPTF  L     +  P  + AL            +DF EP             L+    D + V++     Y  +W+G             N R++ V   P N
Sbjct:    6 GTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKR---RKALCKRKSWMSKVFSGKRLEAEFPPHHS----QSTFRKTSPAPG-GPAGEGPLQSLTCL------------------IGEKDLRLLEKLGDGSFGVVRRGEWD---------APSGKTVSVAVKC---LKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLR--KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA---LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAL------------QDFEEPDK-----------LHIQMNDVITVIEGRAENY--WWRG------------QNTRTLCVGPFPRN 441

[Close]

BLAST of Protein tyrosine kinase vs. TrEMBL
Match: A0A5K3EHV7 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 301.982 bits (772), Expect = 3.127e-80
Identity = 190/601 (31.61%), Postives = 304/601 (50.58%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFR---IGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVF-SIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD------GPDQI-----PSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVL-DRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDV 1910
            +  +FLK A LD Y+   +  LKIR  +QLKYV +I+L  +GM+RPE+RRLKK+FE+E PQT MGK+KKKL RSTS R  +  R                                    T    A   ++   D   +    +I  ++L + + +  GEF  ++   +R   +G+ Q QV+VK ++     +   +F+KE  +   LDHP++++L+G+ +  + ++LVTE   + SLL+CL++P+ + ++ + T HNF +QI+  M+YLEE+R++H  L +RN+LV+  +++KI D GL R+  + +   +T+ N        W A E I+  + T +SD+W++GV LWEM++YG  P   +S  + L +        L QPD C + VF +++ +CW+ +P  RPTF QLT     L P+    + D       P +I     P       +E       +     +L    G+TV VL  +N  L+K          + GY    N+R V   ST +  + +      +  +   ++       S   + A L  IG+          R++ D+IS PQ DFRH+GHV  +G VFGDV
Sbjct:   97 DFYDFLKAADLDEYYSVFSKHLKIRTVSQLKYVTDIELTEMGMSRPEVRRLKKHFERECPQTTMGKLKKKLGRSTSARPPNKQR-----------------------------------ATTEPPADARSSPHADTSGISGYRIIPASELDLASPLGQGEFGRVHQGLWRPSSMGR-QLQVAVKILDLDRFPTKTEDFLKEAAIMNNLDHPDIVRLYGVCVAPKCLRLVTELAPLRSLLECLREPDLRTSFPVSTLHNFAVQIARGMSYLEEERLVHRDLAARNILVFAKDKVKIGDFGLSRALQLGKSYYQTNFNANLRLPIAWCALEAIHDLRFTSASDVWSYGVTLWEMFTYGFVPWAGLSGKQILEAVDVPNSRRLAQPDACPDAVFDAVMRACWNHEPNSRPTFAQLTEMLPHLSPQAWSVVEDSLKTESSPPKIVNDIRPFLTENGSHEADAPDVDNQPSKSLLKVRAGETVYVLSKKNPELWKVVSHSTC---QVGYVPPENLRIV---STTVPSSQRTPGPHHHHHTSGGTLSRMRLRFSRRGSEANLPDIGQSNRGSPRGPMRLNRDLISLPQNDFRHVGHVGADGTVFGDV 655

[Close]

BLAST of Protein tyrosine kinase vs. TrEMBL
Match: A0A2S2PCZ7 (Tyrosine-protein kinase PR2 (Fragment) OS=Schizaphis graminum OX=13262 GN=PR2_3 PE=4 SV=1)

HSP 1 Score: 289.656 bits (740), Expect = 3.437e-79
Identity = 185/595 (31.09%), Postives = 293/595 (49.24%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSN-MRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSLYTSTAQ 1937
            +L EFL EA+L  Y+ E+   LK+    Q+K+V E DL  IGMT+PE+RRLKKYF+K +PQ    K KK +S   +    S     D SG  ++         P+R P                                +KH+I  + +TI   +  GEF  +    +     + QV++K +++  ++++  EF+KE  +   +D+ ++++L+G+ LD + + LVTE   + SLL+CL++P+ + ++ +++  +F IQI   M YLE KR+IH  L +RN+LV+  N++KI+D GL R+  + +   +T+ N        W APE I+  + T SSD+WA+GV LWEM+SYG  P   ++  + L +  +     L QPD C    F+++T CW   P  RP F  L S      PEQ+  + +  D+                     +  M+ Y  G+ + VLD++  +    WKG L NG++G+F  SN +  +G+N  P N         RNS+                          R  S    R  R+ IDMIS PQ D +H+GHV  +G  FGD+  + T+  +
Sbjct:    6 DLYEFLLEAELHQYYSEIKNDLKVMTVPQVKFVTEDDLYQIGMTKPEIRRLKKYFQKYYPQNYFSKFKKLISSKDNKEQWS-----DSSGSQDTLKPIYEKRPPARVP--------------------------------NKHIIPADSITINKELGVGEFGVVQQGVWTNEGDRIQVAIKCLSRERMQNNPIEFLKEAAIMHSIDNEHIVRLYGVVLDTEALMLVTELAPLRSLLECLKEPSLRASFPVMSLCDFAIQICNGMHYLETKRLIHRDLAARNILVFTKNKVKISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECISYLRFTSSSDVWAYGVTLWEMFSYGFQPWAALTGQQILEAIDEPNFQRLEQPDCCPKEYFNVMTKCWQHDPVKRPKFSDLVSILLDCKPEQVQTVVNFEDK---------------------KRDMIQYTIGEIITVLDKSPGV-PTLWKGVLCNGKTGFFNPSNTVAYLGLN-LPSN---------RNSE------------------------FTRNDSKYTSRRSRLRIDMISCPQGDVKHMGHVGLDGAYFGDIEFMSTNAPK 507

[Close]

BLAST of Protein tyrosine kinase vs. TrEMBL
Match: K7IMP9 (Uncharacterized protein OS=Nasonia vitripennis OX=7425 PE=3 SV=1)

HSP 1 Score: 299.286 bits (765), Expect = 4.397e-79
Identity = 184/589 (31.24%), Postives = 291/589 (49.41%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQD-LSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSL 1919
             L EFL EA+L  Y+  +   LK++ TAQLKYV E DL  IGMT+PEMRRLKKYF+K FPQ  + K KK L          +P+ ++ + G L           P R P                                +KH+I  + + +   +  GEF  +    +     + QV++K +++  ++++  EF+KE  +   +DH ++++L+G+ LD  ++ LVTE   + SLL+CL++P+ + ++ + +  +F++QI++ M YLE KR+IH  L +RN+LV+  N++KI+D GL R+  + +   +T+ N        W APE I+  + T +SD+WA+GV LWEM+SYG  P   ++  + L +  +     L QPD C    FS++  CW  +P  RP F +L      L PEQ+ A+ D                        +E+  L Y +GD + VLD+  +     WKG L NG++G+F  +                 H +    S  P+N              F +    G GK+    +  +I  DMIS+PQ D +H GHV  +G  FGD++ L
Sbjct:   66 GLYEFLMEAELQQYYAGIRGDLKVQNTAQLKYVTEEDLCGIGMTKPEMRRLKKYFQKHFPQNYLSKFKKML----------LPKKEEPMPGSLAMLPEERQDRPPIRVP--------------------------------NKHMIPADAIIVNKELGTGEFGVVQQGVWTNDGERIQVAIKCLSRERMQNNPIEFLKEAAIMHSIDHEHIVRLYGVVLDTNSLMLVTELAPLRSLLECLKEPSLRASFPVPSLCDFSVQIADGMQYLEAKRLIHRDLAARNILVFSKNKVKISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECISYLKFTSASDVWAYGVTLWEMFSYGFQPWAALTGHQILEAIDEPNFQRLEQPDCCPKDYFSLMQQCWQHEPTKRPKFSELICLLPDLKPEQVQAVQDN-----------------------SEIGQLTYRQGDVITVLDKGSS--NTLWKGVLNNGKTGFFNPA-----------------HTIAYLGSNLPSNKPGE----------FTR----GDGKNIFSSQRRKIRTDMISSPQGDLKHTGHVGLDGAYFGDISFL 556

[Close]

BLAST of Protein tyrosine kinase vs. TrEMBL
Match: A0A5K3EG80 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 297.745 bits (761), Expect = 8.493e-79
Identity = 187/604 (30.96%), Postives = 306/604 (50.66%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFR---IGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVF-SIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD------GPDQI-----PSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVL-DRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKI-IGRGKSDKKHRTG--RISIDMISAPQKDFRHIGHVSNNGDVFGDV 1910
            +  +FLK A LD Y+   +  LKIR  +QLKYV +I+L  +GM+RPE+RRLKK+FE+E PQT MGK+KKKL RSTS R  +  R                                    T    A   ++   D   +    +I  ++L + + +  GEF  ++   +R   +G+ Q QV+VK ++     +   +F+KE  +   LDHP++++L+G+ +  + ++LVTE   + SLL+CL++P+ + ++ + T HNF +QI+  M+YLEE+R++H  L +RN+LV+  +++KI D GL R+  + +   +T+ N        W A E I+  + T +SD+W++GV LWEM++YG  P   +S  + L +        L QPD C + VF +++ +CW+ +P  RPTF QLT     L P+    + D       P +I     P       +E       +     +L    G+TV VL  +N  L+K          + GY    N+R V   + P ++      +  ++                    +++++   R +S++    G  R++ D+IS PQ DFRH+GHV  +G VFGDV
Sbjct:   97 DFYDFLKAADLDEYYSVFSKHLKIRTVSQLKYVTDIELTEMGMSRPEVRRLKKHFERECPQTTMGKLKKKLGRSTSARPPNKQR-----------------------------------ATTEPPADARSSPHADTSGISGYRIIPASELDLASPLGQGEFGRVHQGLWRPSSMGR-QLQVAVKILDLDRFPTKTEDFLKEAAIMNNLDHPDIVRLYGVCVAPKCLRLVTELAPLRSLLECLREPDLRTSFPVSTLHNFAVQIARGMSYLEEERLVHRDLAARNILVFAKDKVKIGDFGLSRALQLGKSYYQTNFNANLRLPIAWCALEAIHDLRFTSASDVWSYGVTLWEMFTYGFVPWAGLSGKQILEAVDVPNSRRLAQPDACPDAVFDAVMRACWNHEPNSRPTFAQLTEMLPHLSPQAWSVVEDSLKTESSPPKIVNDIRPFLTENGSHEADAPDVDNQPSKSLLKVRAGETVYVLSKKNPELWKVVSHSTC---QVGYVPPENLRIVST-TVPSSQRTPGPHHHHHTSG---------------GTLSRMRLRFSRRESNRGSPRGPMRLNRDLISLPQNDFRHVGHVGADGTVFGDV 645

[Close]

BLAST of Protein tyrosine kinase vs. TrEMBL
Match: A0A5K3EG94 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 297.36 bits (760), Expect = 1.141e-78
Identity = 187/604 (30.96%), Postives = 306/604 (50.66%), Query Frame = 3

Query:  186 NLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFR---IGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE---RTDTNDRKD----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVF-SIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD------GPDQI-----PSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVL-DRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKI-IGRGKSDKKHRTG--RISIDMISAPQKDFRHIGHVSNNGDVFGDV 1910
            +  +FLK A LD Y+   +  LKIR  +QLKYV +I+L  +GM+RPE+RRLKK+FE+E PQT MGK+KKKL RSTS R  +  R                                    T    A   ++   D   +    +I  ++L + + +  GEF  ++   +R   +G+ Q QV+VK ++     +   +F+KE  +   LDHP++++L+G+ +  + ++LVTE   + SLL+CL++P+ + ++ + T HNF +QI+  M+YLEE+R++H  L +RN+LV+  +++KI D GL R+  + +   +T+ N        W A E I+  + T +SD+W++GV LWEM++YG  P   +S  + L +        L QPD C + VF +++ +CW+ +P  RPTF QLT     L P+    + D       P +I     P       +E       +     +L    G+TV VL  +N  L+K          + GY    N+R V   + P ++      +  ++                    +++++   R +S++    G  R++ D+IS PQ DFRH+GHV  +G VFGDV
Sbjct:   97 DFYDFLKAADLDEYYSVFSKHLKIRTVSQLKYVTDIELTEMGMSRPEVRRLKKHFERECPQTTMGKLKKKLGRSTSARPPNKQR-----------------------------------ATTEPPADARSSPHADTSGISGYRIIPASELDLASPLGQGEFGRVHQGLWRPSSMGR-QLQVAVKILDLDRFPTKTEDFLKEAAIMNNLDHPDIVRLYGVCVAPKCLRLVTELAPLRSLLECLREPDLRTSFPVSTLHNFAVQIARGMSYLEEERLVHRDLAARNILVFAKDKVKIGDFGLSRALQLGKSYYQTNFNANLRLPIAWCALEAIHDLRFTSASDVWSYGVTLWEMFTYGFVPWAGLSGKQILEAVDVPNSRRLAQPDACPDAVFDAVMRACWNHEPNSRPTFAQLTEMLPHLSPQAWSVVEDSLKTESSPPKIVNDIRPFLTENGSHEADAPDVDNQPSKSLLKVRAGETVYVLSKKNPELWKVVSHSTC---QVGYVPPENLRIVST-TVPSSQRTPGPHHHHHTSG---------------GTLSRMRLRFSRRESNRGSPRGPMRLNRDLISLPQNDFRHVGHVGADGTVFGDV 645

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Cavefish
Match: tnk2b (tyrosine kinase non receptor 2 [Source:NCBI gene;Acc:103035769])

HSP 1 Score: 160.999 bits (406), Expect = 1.912e-39
Identity = 149/523 (28.49%), Postives = 238/523 (45.51%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQ-DLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFI--NKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNL 1697
            G + LLE L E QL  YF  +   L +   +   YV   DL  IGM RP  RRL +  +K   + AM K K  +S+  S +     RP+ D   +  S   +++   P+        LT + S                      K L L  +L  G+  ++K GE+   +  N ++      V+VK +  + ++    L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+   ++  + I T   + IQI+  M YLE KR IH  L +RN+L+     +KI D GL R+   L + D +      RK    W APE +     + ++D W FGV LWEM +YGQ P   ++ S+ L  + D +   L +P+ C   +++++  CW+++P DRPTF  L     + +P  + AL            +DF+EP             L  +  D + +++     Y  +W+G             N R++ V   P N TV  +  L
Sbjct:    6 GTEWLLELLMEVQLQQYFLRIRDDLNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKK---RKAMCKRKSWMSKVFSGK-----RPEGDFQPQPASTFRKLSPTPPADE--QPQALTCLIS---------------------EKELELCEKLGDGSFGVVKRGEW---FTPNGKV----LNVAVKCLKTDVLNQPDALDDFIREVNAMHSLDHQNLIRLYGVVLT-HPMKMVTELAPLGSLLDRLR--KNQGHFLISTLCQYAIQIANGMAYLESKRFIHRDLAARNILLASSELVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMCTYGQEPWLGLNGSQIL-HKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFMALREFLVETMPTDMRAL------------QDFDEPDK-----------LLIHMNDVITIIEGRAENY--WWRG------------QNKRTLKVGQFPRN-TVTSVAGL 445

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Cavefish
Match: tnk2b (tyrosine kinase non receptor 2 [Source:NCBI gene;Acc:103035769])

HSP 1 Score: 161.384 bits (407), Expect = 1.914e-39
Identity = 149/523 (28.49%), Postives = 238/523 (45.51%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQ-DLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFI--NKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNL 1697
            G + LLE L E QL  YF  +   L +   +   YV   DL  IGM RP  RRL +  +K   + AM K K  +S+  S +     RP+ D   +  S   +++   P+        LT + S                      K L L  +L  G+  ++K GE+   +  N ++      V+VK +  + ++    L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+   ++  + I T   + IQI+  M YLE KR IH  L +RN+L+     +KI D GL R+   L + D +      RK    W APE +     + ++D W FGV LWEM +YGQ P   ++ S+ L  + D +   L +P+ C   +++++  CW+++P DRPTF  L     + +P  + AL            +DF+EP             L  +  D + +++     Y  +W+G             N R++ V   P N TV  +  L
Sbjct:   33 GTEWLLELLMEVQLQQYFLRIRDDLNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKK---RKAMCKRKSWMSKVFSGK-----RPEGDFQPQPASTFRKLSPTPPADE--QPQALTCLIS---------------------EKELELCEKLGDGSFGVVKRGEW---FTPNGKV----LNVAVKCLKTDVLNQPDALDDFIREVNAMHSLDHQNLIRLYGVVLT-HPMKMVTELAPLGSLLDRLR--KNQGHFLISTLCQYAIQIANGMAYLESKRFIHRDLAARNILLASSELVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMCTYGQEPWLGLNGSQIL-HKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFMALREFLVETMPTDMRAL------------QDFDEPDK-----------LLIHMNDVITIIEGRAENY--WWRG------------QNKRTLKVGQFPRN-TVTSVAGL 472

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Cavefish
Match: tnk2b (tyrosine kinase non receptor 2 [Source:NCBI gene;Acc:103035769])

HSP 1 Score: 160.999 bits (406), Expect = 2.245e-39
Identity = 149/523 (28.49%), Postives = 238/523 (45.51%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQ-DLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFI--NKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNL 1697
            G + LLE L E QL  YF  +   L +   +   YV   DL  IGM RP  RRL +  +K   + AM K K  +S+  S +     RP+ D   +  S   +++   P+        LT + S                      K L L  +L  G+  ++K GE+   +  N ++      V+VK +  + ++    L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+   ++  + I T   + IQI+  M YLE KR IH  L +RN+L+     +KI D GL R+   L + D +      RK    W APE +     + ++D W FGV LWEM +YGQ P   ++ S+ L  + D +   L +P+ C   +++++  CW+++P DRPTF  L     + +P  + AL            +DF+EP             L  +  D + +++     Y  +W+G             N R++ V   P N TV  +  L
Sbjct:    6 GTEWLLELLMEVQLQQYFLRIRDDLNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKK---RKAMCKRKSWMSKVFSGK-----RPEGDFQPQPASTFRKLSPTPPADE--QPQALTCLIS---------------------EKELELCEKLGDGSFGVVKRGEW---FTPNGKV----LNVAVKCLKTDVLNQPDALDDFIREVNAMHSLDHQNLIRLYGVVLT-HPMKMVTELAPLGSLLDRLR--KNQGHFLISTLCQYAIQIANGMAYLESKRFIHRDLAARNILLASSELVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMCTYGQEPWLGLNGSQIL-HKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFMALREFLVETMPTDMRAL------------QDFDEPDK-----------LLIHMNDVITIIEGRAENY--WWRG------------QNKRTLKVGQFPRN-TVTSVAGL 445

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Cavefish
Match: tnk2b (tyrosine kinase non receptor 2 [Source:NCBI gene;Acc:103035769])

HSP 1 Score: 160.999 bits (406), Expect = 2.408e-39
Identity = 149/523 (28.49%), Postives = 238/523 (45.51%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQ-DLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGA--IIKHGEFADIYHANFRIGQSQKQVSVKFI--NKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTN-----DRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNL 1697
            G + LLE L E QL  YF  +   L +   +   YV   DL  IGM RP  RRL +  +K   + AM K K  +S+  S +     RP+ D   +  S   +++   P+        LT + S                      K L L  +L  G+  ++K GE+   +  N ++      V+VK +  + ++    L++FI+E+     LDH N+I+L+G+ L    +K+VTE   + SLL  L+   ++  + I T   + IQI+  M YLE KR IH  L +RN+L+     +KI D GL R+   L + D +      RK    W APE +     + ++D W FGV LWEM +YGQ P   ++ S+ L  + D +   L +P+ C   +++++  CW+++P DRPTF  L     + +P  + AL            +DF+EP             L  +  D + +++     Y  +W+G             N R++ V   P N TV  +  L
Sbjct:   32 GTEWLLELLMEVQLQQYFLRIRDDLNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKK---RKAMCKRKSWMSKVFSGK-----RPEGDFQPQPASTFRKLSPTPPADE--QPQALTCLIS---------------------EKELELCEKLGDGSFGVVKRGEW---FTPNGKV----LNVAVKCLKTDVLNQPDALDDFIREVNAMHSLDHQNLIRLYGVVLT-HPMKMVTELAPLGSLLDRLR--KNQGHFLISTLCQYAIQIANGMAYLESKRFIHRDLAARNILLASSELVKIGDFGLMRA---LPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMCTYGQEPWLGLNGSQIL-HKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFMALREFLVETMPTDMRAL------------QDFDEPDK-----------LLIHMNDVITIIEGRAENY--WWRG------------QNKRTLKVGQFPRN-TVTSVAGL 471

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BLAST of Protein tyrosine kinase vs. Ensembl Cavefish
Match: tnk1 (tyrosine kinase non receptor 1 [Source:NCBI gene;Acc:103046563])

HSP 1 Score: 148.288 bits (373), Expect = 6.294e-36
Identity = 129/489 (26.38%), Postives = 208/489 (42.54%), Query Frame = 3

Query:  189 LLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRL----KKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQK-QVSVKFINKVHLK--SDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKD------------WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP-ISMS-ESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKG 1592
            L + L E QL+ ++  +   L +     L YV E DL  IG+++P  RRL    K+Y     P++ M K+                           FS         R P G D  +   S     +    T             LI  N+L  G  +  G F  +  A +     +   V+VK +     +  + + +F++E+     LDHPN+I+L+G+ L  Q +K+VTE   + SL   L+    +  Y +     F+ QI+  M YLE +R IH  L +RNVL+     +KI D GL R          ND+              W APE +     + +SD+W FGV LWEM++Y + P + +S   +  + + +   L +P  C   ++ ++  CW+  P DRPTF QLT+   +  P+++ A+            +DF+EP           + L     D V ++D  + L +  W+G
Sbjct:    9 LYQLLAEVQLERFYLRVRDGLNVTRIEHLDYVKEADLEQIGISKPGQRRLWDAVKRYKTNARPRSWMSKV---------------------------FS--------GRGPEGGDQWSGGGSGQGPEMGRALTC------------LIQDNELVFGERLGSGSFGVVKKAEWHTPTGRVVPVAVKSLRNSMSREPNTVTDFLQEVTTMQSLDHPNIIRLYGVVLT-QPLKMVTELAPLGSLYDMLRIRQGE--YPLARLWLFSTQIAAGMEYLETRRFIHRDLAARNVLLASRELVKIGDFGLMRGLG-------NDKDHYIMGAHRRIPFAWCAPESLRVGSFSHASDVWMFGVTLWEMFTYCEEPWLGLSGRQILYRVEREGDRLQRPLDCPQELYVVMKMCWAYIPSDRPTFAQLTTLVAEAQPKEVRAV------------QDFSEP-----------RKLALQASDLVTMIDHGLELGE--WRG 415

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Sea Lamprey
Match: txk (TXK tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-130530-553])

HSP 1 Score: 124.405 bits (311), Expect = 1.410e-30
Identity = 75/244 (30.74%), Postives = 122/244 (50.00%), Query Frame = 3

Query:  693 RIGQ--SQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRK-----DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPI-SMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKL 1400
            R+GQ   QK V+VK I +  +  +  +FI+E  V   L HP +++L+G+    + + +VTE +   SLL  L+         ++      + + EAM+YLEEK  +H  L +RN LV   N +K++D G+     +L+   T          W  PE+   ++ +  SD+W+FGVL+WE+Y+ G  P    S        L+   L+QP L     ++I+  CW E+P  R +F +L      L
Sbjct:  134 RLGQWKRQKLVAVKMIQEGAMSEE--DFIEEAKVMMQLSHPRLVQLYGVCTQQRPLCIVTEYMVGGSLLSFLKSQRGSTVPELMA--EICLDVCEAMSYLEEKMFLHRDLAARNCLVGEGNIVKVSDFGMTSHRYVLDDQYTCSMGAKFPVKWSPPEVFQYTRFSTKSDVWSFGVLMWEVYTEGHMPFEGWSNQQVVDEILRGCRLYQPALSPPTAYNIMLDCWQEKPESRCSFIELLPRIRAL 373

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Sea Lamprey
Match: fgfr2 (fibroblast growth factor receptor 2 [Source:NCBI gene;Acc:352940])

HSP 1 Score: 127.872 bits (320), Expect = 2.037e-30
Identity = 98/348 (28.16%), Postives = 161/348 (46.26%), Query Frame = 3

Query:  465 SFSVRMNGNGPSRSPI-------GSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQK-----QVSVKFINKVHLKSDLNEFIKEM-FVQCYLDHPNVIKLFGISLDDQNIKLVTE---QLNVSSLLKCLQDPNSKITY-----------SILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILE--RTDTNDR--KDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKL----HYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLI 1403
            + SV  NG+  S  P+        S D  T+A V+ + +         D R   S+       LT+G  +  G F  +  A       +K     +V+VK + +     DL + + EM  ++    H N+I L G       + ++ E   + N+   L+  + P ++ T+           SI    +FT Q++  M YL  K+ IH  L +RNVLV  DN +KI D GL R  + ++  +  +N R    W+APE +     T  SD+W+FGVLLWE+++ G  P      +  +   KL    H + +P LCS  ++ ++  CW+  P  RPTF QL  + ++++
Sbjct:  225 TVSVESNGSMNSSVPLVMRGGRFSSGDSPTLAGVSEYELTE-------DPRWEFSREW-----LTLGKPLGEGCFGQVVMAEALGIDKEKPNRSLRVAVKMLKEDATDKDLYDLVSEMEMMKNIGKHKNIINLLGACTQGGPLYVIVEFAAKGNLREFLRARRPPGTEYTFEGAAAAQGEQLSIKELVSFTYQVARGMEYLASKKCIHRDLAARNVLVTDDNVMKIADFGLARDVNYIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP---GIPVEELFKLLKEGHRMDRPALCSTELYMMMKDCWAAVPSHRPTFKQLVEDLDRIL 557

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7])

HSP 1 Score: 121.709 bits (304), Expect = 1.309e-29
Identity = 84/297 (28.28%), Postives = 147/297 (49.49%), Query Frame = 3

Query:  525 LTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSY---SILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHY-LFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLI 1403
            +  V S   F + S+ T D +++++  S  L+ Q    +GA    G+F ++Y     +     +V+VK +    +  +  EF+ E  +     H N+I+L+ +   ++ I ++TE +   SLL+ LQ+    +   +    N  +Q++  M YLE +  IH  L +RN+LV  +   K+ D GL R       + R        W APE  N S+ T+ SD+W+FG+LL+E+ +YG+ P +   +     +L+  Y +  P  C    +SI+ +CW ++   RP+F QL      LI
Sbjct:   97 VCMVTSPVTFGL-SHDTVDQWEVKR-SSIELLRQ----LGA----GQFGEVYEG---LWNKTTRVAVKTLKPGAMVPE--EFLAEAHIMKRFTHCNLIQLYAVCTTEEPIYIITELMVNGSLLQYLQNDEGGVL-KMCHLINMAVQVASGMAYLEAQNYIHRDLAARNILVGDNLTCKVADFGLARVIKDDEYIAREGGKFPVKWTAPEAANYSRFTIKSDVWSFGILLYEIVTYGKVPYAGMTNAEVLEELEHGYRMPCPTNCPRDFYSIMYNCWHKEEACRPSFLQLDHQLEDLI 377

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BLAST of Protein tyrosine kinase vs. Ensembl Sea Lamprey
Match: abl1 (c-abl oncogene 1, non-receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-100812-9])

HSP 1 Score: 125.946 bits (315), Expect = 2.775e-29
Identity = 79/282 (28.01%), Postives = 136/282 (48.23%), Query Frame = 3

Query:  570 GTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFR---SYSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHY-LFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLI 1403
            G + +YD      +  I +  +T+   +  G++ ++Y    +  +  + V+VK +N      ++ EF+KE  +   + HPN+++L G+   +    +VTE +   +LL  L++ N     +++  H  T QIS AM YLE+K  IH  L +RN LV   + +K+ D GL R     +   R        W APE +  ++        AFGVLLWE+ +YG  P    +       L+  Y + QP+ C   V+ ++ +CW     DRP+F ++   F  + 
Sbjct:  202 GVSPTYD------RWEIERTDITMKHKLGGGQYGEVYEGLKK--KYSRTVAVKTLNPREDTMEVEEFLKEAAMMKEIKHPNLVQLLGVCTREPPFYIVTEFMTHGNLLDYLRECNRDEVTAVVLLHMAT-QISSAMEYLEKKNFIHRDLAARNCLVAESHMVKVADFGLSRLMTGDTYTARAGAKFPIKWTAPESLAYNKFCAPVSCSAFGVLLWEIATYGMSPYPGVDLSQVYERLERGYRMEQPEGCPPRVYQLMQACWQWNAADRPSFAEIHQTFETMF 474

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7])

HSP 1 Score: 120.939 bits (302), Expect = 6.443e-29
Identity = 82/291 (28.18%), Postives = 141/291 (48.45%), Query Frame = 3

Query:  528 TTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRK------DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHY-LFQPDLCSNMVFSIITSCWSEQPRDRPTFYQL 1379
              + + T   ++ N T D ++I +       +Q Q  +GA    G F +++     +  +   V+VK +    +K +  EFI E  +   L H N+I+L+ +   ++ I ++TE +   SLL  L+ P  K         +   QI+  M YLE +  IH  L +RN+LV      K+ D GL R   +    +   +        W APE +N  + ++ SD+W+FG+LL+E+ +YG+ P     ++     L   Y + QPD C  + +SI+  CW+++  +RPTF  L
Sbjct:  164 VVIEAPTTIGLSYN-TVDKWEIPRAS-----IQLQKRLGA----GMFGEVWQG---LWNNSTLVAVKTLKPGAMKKE--EFIGEAQIMKQLRHANLIQLYAVCSQEEPIYIITELMRHGSLLDYLRGPLGK-QLKAPELVDMARQIAAGMAYLESQNYIHRDLAARNILVGEGKVCKVADFGLARIIKVRYEDEYEGKAGAKVPIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYGRMPYPEMGNMEVLKQLDRGYRMPQPDNCPPLFYSIMLECWNKKEEERPTFETL 438

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931])

HSP 1 Score: 81.6481 bits (200), Expect = 3.163e-16
Identity = 68/265 (25.66%), Postives = 119/265 (44.91%), Query Frame = 3

Query:  636 TIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQD------PNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLF-RSYSILERTDTNDRKDWIAPEIINGSQPTLS--SDIWAFGVLLWEMYSYGQYPISMSESLGSQSDL------KLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTS 1385
            +I + I  G F D+Y A  R+  +Q+ V++K +N  H   D+    +E+F    L  P +       L+D ++ +V E     S    L+       P  K+++ I   H  T+     + YL E+R IH  + + N+L+  +  +K+ D G+     S L+R        W+APE++       +  +DIW+ G+  +E+   G  P+S  + +   ++L      KL   F     S+     +  C  + P DRP+ Y L S
Sbjct:   19 SIQSCIGRGNFGDVYKAVDRV--TQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFII---HEVTL----GLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKRDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLK-GLPPLSKYDPMKVMTNLPKRKPPKLQGPF-----SDAAKDFVAGCLVKTPADRPSAYNLLS 268

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 74.7146 bits (182), Expect = 3.085e-14
Identity = 59/216 (27.31%), Postives = 106/216 (49.07%), Query Frame = 3

Query:  798 LDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGS-----QSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSN---FNKLIPEQLIA 1421
            + HP +I+++G   D Q + +V + +    L   L+  + +    +  F  +  ++  A+ YL  K II+  L   N+L+  +  IKITD G  +    +  T      D+IAPE+++      S D W+FGVL++EM + G  P   S ++ +      ++LK    F PD   +++  +IT   SE+  +     +   N   FN++I E+L+A
Sbjct:  143 VSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRK-SQRFPNPVAKF--YAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCG-TPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLA-GYTPFYNSNTMKTYENILNAELKFPPFFHPD-AQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLA 352

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Yeast
Match: IPL1 (Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest [Source:SGD;Acc:S000006130])

HSP 1 Score: 72.0182 bits (175), Expect = 1.582e-13
Identity = 49/159 (30.82%), Postives = 87/159 (54.72%), Query Frame = 3

Query:  765 EFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQ--DPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRK------DWIAPEIINGSQPTLSSDIWAFGVLLWEMYS 1217
            +F +E+ +Q  L+HPN+ K +G   D++ + L+ E L    + K L+   P + I  S     ++  QI+ A+ Y+ +K IIH  +   N+L+  +N IK+TD G    +SI+   + N RK      D+++PE++   +   + D WA GVL +E+ +
Sbjct:  148 QFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILAS-----DYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFG----WSIINPPE-NRRKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLT 296

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757])

HSP 1 Score: 71.2478 bits (173), Expect = 6.490e-13
Identity = 71/292 (24.32%), Postives = 139/292 (47.60%), Query Frame = 3

Query:  588 DIRQL---GSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHP----NVIKLFGISLDDQN--IKLVTEQLNVSSL---LKCLQDPNSKITYSILTFHNFTIQISEA----MTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPIS---MSESLGSQSDLKLHYLFQPDLC----SNMVF-----SIITSCWSEQPRDRPTFYQL 1379
            D+ QL   G K+  L++++    I+  G    +     + G   K  ++K IN ++      E+ K++F +   +       +++ +G+  DD+N  I +  E +   SL    K L +   +I+  +L       +I+EA    ++YL EK++IH  +  +N+L+  + Q+K+ D G+         T       ++APE I G   +++SD+W+ G+ + E+ + G++P S   M+ ++     L     F P+L     SN+++     S I  C  +  R+RP+  Q+
Sbjct:  203 DVDQLDENGWKYANLKDRIETLGILGEGAGGSVSKCKLKNGS--KIFALKVINTLNTDP---EYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLG------KIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEV-ANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQM 482

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 69.707 bits (169), Expect = 2.496e-12
Identity = 48/161 (29.81%), Postives = 82/161 (50.93%), Query Frame = 3

Query:  777 EMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQL---NVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKD------WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP 1232
            EM +   L H N++  +G S +  N+ +  E +   +VSS+L      N+   +      NFT QI   + YL +K IIH  +   N+L+     +KITD G+ +  S L +   N R        W++PE++  +  T  +DIW+ G ++ EM++ G++P
Sbjct:  504 EMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSML------NNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQ-NKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFT-GKHP 656

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Nematostella
Match: EDO41796 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S358])

HSP 1 Score: 147.132 bits (370), Expect = 2.927e-39
Identity = 84/266 (31.58%), Postives = 146/266 (54.89%), Query Frame = 3

Query:  651 IKHGEFADIYHANFRIGQSQKQ--VSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISL----DDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP------ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLI 1403
            I  G FA++    + IG ++++  V++K I    L+  L + ++E      LDH N+I+L+GI+L        IKLVTE     SL + L++PN      +     F++QI++ M YL  + ++H  L +RNVLV     ++I+D GL ++    +   T  R+    W APE++ G +     D+W++GVLLWEMYS+G+ P      + + + +  Q + KL    QP  C + ++ ++  CW  +P+DRP F ++ S+ +K++
Sbjct:   13 IGEGFFANVALGKW-IGPNKREQFVAIKSIKGNFLEDHLEDVLREADTMMSLDHRNIIRLYGIALITSKTPMGIKLVTEYAVFGSLSEILKNPNKPEFLQVTRLRKFSLQIADGMEYLANRHLVHRDLAARNVLVVEPELVRISDFGLAKALDQGQEI-TAGREMAIAWCAPEVLKGREVHPKCDVWSYGVLLWEMYSFGKRPWDGIPIMQVMKIVTQQPEKKLE---QPKACPSELYELMLHCWVHEPQDRPGFAEIRSSISKVL 273

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Nematostella
Match: EDO47802 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL50])

HSP 1 Score: 146.362 bits (368), Expect = 3.020e-37
Identity = 115/433 (26.56%), Postives = 201/433 (46.42%), Query Frame = 3

Query:  174 TGMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQK-QVSVKFINK------VHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKD-----WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQ--YPISMSESLGSQSDLKL-HYLFQPDLCSNMVFSIITS-CWSEQPRDRPTFYQLTSNFNKLIPEQLIAL 1424
            T  + +L+ L+  QLD +  ++  +L +       +V E DL  +GM +P  RRL +  +K   +   G  ++K+          V R   L    +S+        P  +P G   LT                            LI ++ L +  +I  G F  +    +      K  V+VK +        + +++D   FIKE      LDHP++I+LFGI L    + LVTE   +  LL  L+  N++  + + T  +F IQ++  M YLE KR IH  L +RNVL+  + ++KI D GL R+ S+ +   T + K      W  PE +   + + +SD+W+FG+ + E++SYG+  +P      + ++ D+ L     +P  C ++++S++ S CW+  P +R  F +L  +  ++ P  + A+
Sbjct:    4 TEEEKILDILRGVQLDQFHRQIVDRLHVTRVNHFDHVTEEDLDGLGMAKPAQRRLFEAIKKGKRRNLFGSFRRKVG--------DVDRGNKLLPEPSSYP-----KSPITTPAGPC-LTC---------------------------LITESSLVLYEMIGDGAFGYVRKGQWTTDTGTKVDVAVKCLKFSADAAFIQMQTD---FIKEANSMALLDHPHIIRLFGIVLSTP-MMLVTELAPLGCLLTALR--NNRQRFMVSTLCDFMIQVASGMAYLESKRFIHRDLAARNVLLESNEKVKIGDFGLMRALSVEDDYYTMNPKGKVPFAWCPPEALKYRKFSHASDVWSFGICVIELFSYGEEPWPGLNGAQILAKVDMPLCERPLKPSHCPSLIYSLLVSLCWAHDPSNRAGFSELKKSLEQVRPHDVRAV 389

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BLAST of Protein tyrosine kinase vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18])

HSP 1 Score: 126.716 bits (317), Expect = 5.970e-32
Identity = 77/267 (28.84%), Postives = 133/267 (49.81%), Query Frame = 3

Query:  618 ILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHY-LFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIP 1406
            I + ++ +   +  G++ ++Y   ++  +  K V+VK + +  +  ++ EF+KE  V   + H N+++L G+   +    ++TE +   +LL  L+ P  K     +T      Q+  AM+YLE    IH  L +RN LV  +N +K+ D GL R  S    T     K    W APE +  +  ++ SD+WAFG+LLWE+ +YG  P    +       L   Y +  P+ C   V+S++ +CW   P  RP+F ++    N + P
Sbjct:    9 IERTEIAMKHKLGGGQYGEVYEGTWK--KYNKTVAVKTLREETM--EVEEFLKEASVMKGIKHQNLVQLLGVCTREPPFYIITEFMMNGNLLDYLRSPKGK-DLDAVTLMYMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLVSEDIYTAHQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYRMPCPEGCPPEVYSLMQTCWCWDPNSRPSFKEIHEKLNTMFP 270

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Nematostella
Match: EDO49126 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGW8])

HSP 1 Score: 123.635 bits (309), Expect = 2.002e-30
Identity = 85/285 (29.82%), Postives = 136/285 (47.72%), Query Frame = 3

Query:  633 LTIGAIIKHGEFADIYHA---NFRIGQSQKQ--VSVKFINKVHLKSDLNEFIKEMFVQCYL-DHPNVIKLFGISLDDQNIKLVTEQLNVSSL---LKCLQD------------PNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFR------SYSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHY-LFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLI 1403
            +  G ++  G F  +  A       G   K+  V+VK +N +    D   F+ E+ +   L  H N++ + G       + L+TE      L   L+ ++D            P  ++T + L   +F  QI+  M YL +K  +H  L +RN+L+  DN +KI+D GL R       Y  +  T     K W+APE I  +  T  SD+WAFGV+LWE+ + G  P            LK  Y + +PD+CS  +++++ SCW+  P DRPTF +L +   +L+
Sbjct:   18 IAFGEVVGSGAFGKVTKATIVGLPGGPENKETVVAVKKLNAMATMEDRRNFLSEIEMMKQLGKHLNIVSILGCVTHAGQLCLITEYCPYGDLRNYLRAIRDKVSTRDSLAGRAPGRELTQNDLL--SFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVYESSEYHKMHNTGKLPLK-WMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKEFYKKLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKLRNQLEQLM 299

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Nematostella
Match: EDO33736 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD7])

HSP 1 Score: 122.865 bits (307), Expect = 1.018e-29
Identity = 78/281 (27.76%), Postives = 140/281 (49.82%), Query Frame = 3

Query:  618 ILQNQLTIGAIIKHGEFADIYHANF-RIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKD-----------WIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHY-LFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLI--PEQL 1415
            I ++ L +  II  GEFAD+Y        ++Q++V+VK +       +  +F  E  +    DHPNVI L G+    + + ++TE L   SL   L+  + ++T   L        ++  M YL E   IH  L +RN+LV  +   K++D GL R    L+ +  N++ +           W APE I   + + +SD+W++G+LLWE+ S+G+ P    ++      ++  Y L  P  C  ++ +++  CW ++   RP F  +   F+++I  P+++
Sbjct:   22 INKDDLKLEIIIGGGEFADVYRGVLTNEDKTQEKVAVKILKPGSSHKNREDFCVEASIMGQFDHPNVIALKGVITRTRPMMIITEFLENGSLDNFLKSNDGRLT--TLQLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRE---LDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGILLWEIMSFGERPYWTWDNFQVMDRVEGGYRLPAPMKCPKVIHNLMLDCWDKEKTSRPKFADIVRRFDEVIRSPDKM 297

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Medaka
Match: tnk2b (activated CDC42 kinase 1 [Source:NCBI gene;Acc:101170708])

HSP 1 Score: 172.17 bits (435), Expect = 7.408e-43
Identity = 136/443 (30.70%), Postives = 209/443 (47.18%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLL---KCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRS-------YSILERTDTNDRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALT--DGPDQI 1445
            G + LLE L E QL  YF  +   L +   +   YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +     RP         F  +       R    +  L     V   S  S G T + D++Q     LI +  LT+   +  G F  +    +     +  V+VK +    L     L +FI E+     LDH N+I+L+G+ L    +K+VTE   + SLL   +CLQ P       I T   + +Q++  M YLE++R IH  L +RN+L+    ++KI D GL R+       Y + E      RK    W APE +     + ++D W FGV LWEM++YGQ P   ++ S+ L  + D +   L +P+ C   +++++  CW+++P DRPTF  L     + +P  + AL   D PD++
Sbjct:    6 GTEWLLELLMEVQLQQYFLRIQDDLNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGK-----RPDG-----GEFPQQSQPASSFRKLSPTPPLCLGEGV--LSTQSGGGT-TLDVQQKALTCLISEKDLTLFEKLGDGSFGVVKRGEWMTPSGKLNVAVKCLKTDVLSQPDALEDFICEVNAMHSLDHQNLIRLYGVVLT-HPMKMVTELAPLGSLLGRLRCLQGP-----ILISTLCQYAVQVACGMAYLEQRRFIHRDLAARNILLASAQRVKIGDFGLMRALPNNHEHYVMQEH-----RKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMFTYGQEPWLGLNGSQIL-HKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFVSLREFLLETLPTDMCALQDFDEPDKL 420

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Medaka
Match: tnk2b (activated CDC42 kinase 1 [Source:NCBI gene;Acc:101170708])

HSP 1 Score: 172.555 bits (436), Expect = 7.576e-43
Identity = 136/443 (30.70%), Postives = 209/443 (47.18%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLL---KCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRS-------YSILERTDTNDRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALT--DGPDQI 1445
            G + LLE L E QL  YF  +   L +   +   YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +     RP         F  +       R    +  L     V   S  S G T + D++Q     LI +  LT+   +  G F  +    +     +  V+VK +    L     L +FI E+     LDH N+I+L+G+ L    +K+VTE   + SLL   +CLQ P       I T   + +Q++  M YLE++R IH  L +RN+L+    ++KI D GL R+       Y + E      RK    W APE +     + ++D W FGV LWEM++YGQ P   ++ S+ L  + D +   L +P+ C   +++++  CW+++P DRPTF  L     + +P  + AL   D PD++
Sbjct:   39 GTEWLLELLMEVQLQQYFLRIQDDLNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGK-----RPDG-----GEFPQQSQPASSFRKLSPTPPLCLGEGV--LSTQSGGGT-TLDVQQKALTCLISEKDLTLFEKLGDGSFGVVKRGEWMTPSGKLNVAVKCLKTDVLSQPDALEDFICEVNAMHSLDHQNLIRLYGVVLT-HPMKMVTELAPLGSLLGRLRCLQGP-----ILISTLCQYAVQVACGMAYLEQRRFIHRDLAARNILLASAQRVKIGDFGLMRALPNNHEHYVMQEH-----RKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMFTYGQEPWLGLNGSQIL-HKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFVSLREFLLETLPTDMCALQDFDEPDKL 453

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Medaka
Match: tnk2b (activated CDC42 kinase 1 [Source:NCBI gene;Acc:101170708])

HSP 1 Score: 172.555 bits (436), Expect = 8.103e-43
Identity = 136/443 (30.70%), Postives = 209/443 (47.18%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD--LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLL---KCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRS-------YSILERTDTNDRK---DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALT--DGPDQI 1445
            G + LLE L E QL  YF  +   L +   +   YV   DL  IGM RP  RRL +  ++   + AM K K  +S+  S +     RP         F  +       R    +  L     V   S  S G T + D++Q     LI +  LT+   +  G F  +    +     +  V+VK +    L     L +FI E+     LDH N+I+L+G+ L    +K+VTE   + SLL   +CLQ P       I T   + +Q++  M YLE++R IH  L +RN+L+    ++KI D GL R+       Y + E      RK    W APE +     + ++D W FGV LWEM++YGQ P   ++ S+ L  + D +   L +P+ C   +++++  CW+++P DRPTF  L     + +P  + AL   D PD++
Sbjct:   71 GTEWLLELLMEVQLQQYFLRIQDDLNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKR---RKAMCKRKSWMSKVFSGK-----RPDG-----GEFPQQSQPASSFRKLSPTPPLCLGEGV--LSTQSGGGT-TLDVQQKALTCLISEKDLTLFEKLGDGSFGVVKRGEWMTPSGKLNVAVKCLKTDVLSQPDALEDFICEVNAMHSLDHQNLIRLYGVVLT-HPMKMVTELAPLGSLLGRLRCLQGP-----ILISTLCQYAVQVACGMAYLEQRRFIHRDLAARNILLASAQRVKIGDFGLMRALPNNHEHYVMQEH-----RKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMFTYGQEPWLGLNGSQIL-HKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFVSLREFLLETLPTDMCALQDFDEPDKL 485

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Medaka
Match: tnk2a (activated CDC42 kinase 1 [Source:NCBI gene;Acc:101171868])

HSP 1 Score: 168.318 bits (425), Expect = 9.917e-42
Identity = 134/431 (31.09%), Postives = 210/431 (48.72%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSV-RMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIG--AIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD-LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRS------YSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD 1430
            G + LLE L + QL  YF  +  +L +   +   YV   DL  IGM RP  RRL +  ++   + A+ K K  +S+                     F V R++ + P   P G+      AS+   + +  G + +  IR+     L L  +L  G   +++ GE+      N R+      V+VK +    L SD L++FI+E+     L+H N+I+L+GI L  Q +K+VTE   + SL   L+     I   IL   N+ IQ++  M YLE++R +H  L +RNVL+  +  +KI D GL R+      + I+E         W APE +     + +SD W FGV LWEM+S+GQ P   ++ S+ L  + D++   L +P  C   +++++  CWS  P DRPTF  L     + +P  + AL D
Sbjct:   39 GTEWLLELLTDVQLQQYFLRIRDELNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKR---RRALYKRKSWMSKV--------------------FPVKRLDSDSPQTFPSGA------ASLAGPAGSEPGASLTCLIRE---PELQLLERLGDGTFGVVRRGEWT---APNGRV----LSVAVKCLKTGVLDSDGLDDFIREVNAMHSLNHQNLIRLYGIVLT-QPMKMVTELAPLGSLQDRLRKRQGHIL--ILLLCNYAIQVACGMAYLEKRRFLHRDLAARNVLLSSNEAVKIGDFGLMRALPSHTDHYIMEEGHKIPFP-WCAPESLKSRSFSHASDTWMFGVTLWEMFSHGQEPWLGLNGSQIL-HKVDVEAERLCKPADCPQDIYNVMLQCWSPTPEDRPTFIALRDFLLETMPTDMRALQD 425

[Close]

BLAST of Protein tyrosine kinase vs. Ensembl Medaka
Match: tnk2a (activated CDC42 kinase 1 [Source:NCBI gene;Acc:101171868])

HSP 1 Score: 168.318 bits (425), Expect = 1.122e-41
Identity = 134/431 (31.09%), Postives = 210/431 (48.72%), Query Frame = 3

Query:  177 GMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSV-RMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIG--AIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSD-LNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRS------YSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYP---ISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTD 1430
            G + LLE L + QL  YF  +  +L +   +   YV   DL  IGM RP  RRL +  ++   + A+ K K  +S+                     F V R++ + P   P G+      AS+   + +  G + +  IR+     L L  +L  G   +++ GE+      N R+      V+VK +    L SD L++FI+E+     L+H N+I+L+GI L  Q +K+VTE   + SL   L+     I   IL   N+ IQ++  M YLE++R +H  L +RNVL+  +  +KI D GL R+      + I+E         W APE +     + +SD W FGV LWEM+S+GQ P   ++ S+ L  + D++   L +P  C   +++++  CWS  P DRPTF  L     + +P  + AL D
Sbjct:    6 GTEWLLELLTDVQLQQYFLRIRDELNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKR---RRALYKRKSWMSKV--------------------FPVKRLDSDSPQTFPSGA------ASLAGPAGSEPGASLTCLIRE---PELQLLERLGDGTFGVVRRGEWT---APNGRV----LSVAVKCLKTGVLDSDGLDDFIREVNAMHSLNHQNLIRLYGIVLT-QPMKMVTELAPLGSLQDRLRKRQGHIL--ILLLCNYAIQVACGMAYLEKRRFLHRDLAARNVLLSSNEAVKIGDFGLMRALPSHTDHYIMEEGHKIPFP-WCAPESLKSRSFSHASDTWMFGVTLWEMFSHGQEPWLGLNGSQIL-HKVDVEAERLCKPADCPQDIYNVMLQCWSPTPEDRPTFIALRDFLLETMPTDMRALQD 392

[Close]

BLAST of Protein tyrosine kinase vs. Planmine SMEST
Match: SMESG000064360.1 (SMESG000064360.1)

HSP 1 Score: 2360.87 bits (6117), Expect = 0.000e+0
Identity = 1190/1193 (99.75%), Postives = 1192/1193 (99.92%), Query Frame = 3

Query:   96 MLTDNNSSSFRNGYEFXXXXXXXXXXTGMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNXXXXXXXXXXXXEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSLYTSTAQQKIRSGTISVCSKLNTSTSLSEASSVISTSTLNAAGDDTPPYATIDNETSKTLSEKHSSKPNQSNVLIPPPLPPTRSYSEDEVDSSCLMNDLELSNEFSLCNDGFSLFNELSKQWDIQCSCLDSEATPTSDSKVHISETKSSLSSDCPTIITFDSSMESPVTRKSENISETSEVEKPPNRPMKIPITSSNSVSSPTFKASLGNHHSIRSSSFFTKIRTLGNGKTSKSKEIPSPTDFTQTIPSPLYAXXXXXXXXXXXXETNSKKNIISHPILISAPVVTSVNIPEENYLDCSSEVSSLQPSPRESVIGTPYSYAFNMNANQDQSALLSRQHSNVTSCTKITNGSTTSVSPASSFVSLTSAPISNLPQSGAAIRAIKKGDGVFRATAVSNRRRPSASDQFLNDGTLSRTRQPSLPMVSTMNRINSSTIDRRLYSRSGISNNDLLESVLDSSATTPIASELPDLPYIDLSFARPPTEDKINPVDEDDAYNSLHFGSIGSDTIETHCSIKLSDSAYDHQDSLKAKESSLFQFSKNSNPPKSDLSFFNENPFSLCLDSSSTFNSYQIQTNKFTNFGENDEIAL 3674
            MLTDNNSSSFRNGYEFNNNGSVSSNSTGMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNSVRSSGRSRSVGEAFAKLKIIGRGKSDKK+RTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSLYTSTAQQKIRSGTISVCSKLNTSTSLSEASSVISTSTLNAAGDDTPPYATIDNETSKTLSEKHSSKPNQSNVLIPPPLPPTRSYSEDEVDSSCLMNDLELSNEFSLCNDGFSLFNELSKQWDIQCSCLDSEATPTSD+KVHISETKSSLSSDCPTIITFDSSMESPVTRKSENISETSEVEKPPNRPMKIPITSSNSVSSPTFKASLGNHHSIRSSSFFTKIRTLGNGKTSKSKEIPSPTDFTQTIPSPLYAKIKKPGKIKKQKETNSKKNIISHPILISAPVVTSV IPEENYLDCSSEVSSLQPSPRESVIGTPYSYAFNMNANQDQSALLSRQHSNVTSCTKITNGSTTSVSPASSFVSLTSAPISNLPQSGAAIRAIKKGDGVFRATAVSNRRRPSASDQFLNDGTLSRTRQPSLPMVSTMNRINSSTIDRRLYSRSGISNNDLLESVLDSSATTPIASELPDLPYIDLSFARPPTEDKINPVDEDDAYNSLHFGSIGSDTIETHCSIKLSDSAYDHQDSLKAKESSLFQFSKNSNPPKSDLSFFNENPFSLCLDSSSTFNSYQIQTNKFTNFGENDEIAL
Sbjct:    1 MLTDNNSSSFRNGYEFNNNGSVSSNSTGMDNLLEFLKEAQLDHYFDELNLKLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKKLSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASVTNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKDWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGCLLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNSVRSSGRSRSVGEAFAKLKIIGRGKSDKKYRTGRISIDMISAPQKDFRHIGHVSNNGDVFGDVTSLYTSTAQQKIRSGTISVCSKLNTSTSLSEASSVISTSTLNAAGDDTPPYATIDNETSKTLSEKHSSKPNQSNVLIPPPLPPTRSYSEDEVDSSCLMNDLELSNEFSLCNDGFSLFNELSKQWDIQCSCLDSEATPTSDNKVHISETKSSLSSDCPTIITFDSSMESPVTRKSENISETSEVEKPPNRPMKIPITSSNSVSSPTFKASLGNHHSIRSSSFFTKIRTLGNGKTSKSKEIPSPTDFTQTIPSPLYAKIKKPGKIKKQKETNSKKNIISHPILISAPVVTSVIIPEENYLDCSSEVSSLQPSPRESVIGTPYSYAFNMNANQDQSALLSRQHSNVTSCTKITNGSTTSVSPASSFVSLTSAPISNLPQSGAAIRAIKKGDGVFRATAVSNRRRPSASDQFLNDGTLSRTRQPSLPMVSTMNRINSSTIDRRLYSRSGISNNDLLESVLDSSATTPIASELPDLPYIDLSFARPPTEDKINPVDEDDAYNSLHFGSIGSDTIETHCSIKLSDSAYDHQDSLKAKESSLFQFSKNSNPPKSDLSFFNENPFSLCLDSSSTFNSYQIQTNKFTNFGENDEIAL 1193

[Close]

BLAST of Protein tyrosine kinase vs. Planmine SMEST
Match: SMESG000051839.1 (SMESG000051839.1)

HSP 1 Score: 150.599 bits (379), Expect = 1.081e-36
Identity = 96/302 (31.79%), Postives = 158/302 (52.32%), Query Frame = 3

Query:  558 IASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFRIGQSQ-KQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRK-----DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHY-LFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQ 1442
            + S    ++ +IR + S  +IL  +L        GEF ++Y     +   Q ++V+VK + +   + D   F+KE  +   L HPN+I ++G+  +++ + ++ E  N+ SLL  L D   KI  S L  HN+ +QI+  MTYLE K  +H  L  RNVL+  ++  KI+D GL R+  +        R+      W APE I     + +SD+W++GV LWEM+S G++P +  +S      ++    L +P L S+ V+ ++  CW+ +P DRPTF  L + F+ L    +    D PD 
Sbjct:  519 VWSQMANNNSEIRMIPSDAVILLYRLG------EGEFGEVYRGRLHLDNGQMEEVAVKVLVQPSQRLD---FMKEASIMMQLSHPNIITMYGVC-ENKRLMMILEVANLGSLLDYLLDYPEKIQLSDL--HNWAMQIASGMTYLESKGFVHRDLACRNVLLSSESCCKISDFGLSRAVGVESDYYKATRRGKWPVKWYAPESIYYKTFSHASDVWSYGVCLWEMWSLGEHPYAQQDSFEVLRQIEEGVRLPRPKLTSDKVYMLMQQCWAYRPEDRPTFSHLLAVFSHLC-TNIYENVDPPDH 807

[Close]

BLAST of Protein tyrosine kinase vs. Planmine SMEST
Match: SMESG000056885.1 (SMESG000056885.1)

HSP 1 Score: 129.798 bits (325), Expect = 5.377e-30
Identity = 88/255 (34.51%), Postives = 136/255 (53.33%), Query Frame = 3

Query:  660 GEFADIYHANFRIGQSQKQVSVKFINKVHLKSDLN----EFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNS-KITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRK-------DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHY-LFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTS 1385
            G++ D+Y A ++  +    ++VK      LK DLN    +F+KE  V   L H N+++L G+ + +    L+TE ++  +LL  L+  N  ++T SIL +     QI++ MTYLEE   IH  L +RN LV  +  +K+ D GL R    ++R D+   K        W APE +  ++ +  SDIWAFGV+LWE+ +YG  P    E       L+  Y + +P+ C  +V+ I+  CW   P  RP+F QL S
Sbjct:  258 GQYGDVYEAVWK--RYNVVIAVK-----TLKEDLNLKIEDFLKEALVMKNLRHKNLVQLLGVCIKEPPFYLITEYISKGNLLHFLRKCNQLEVTPSILLY--MATQIADGMTYLEENNFIHRDLAARNCLVGDNYLLKVGDFGLAR---YIQRDDSYTAKIGAKFPIKWTAPEGLAFNKFSSKSDIWAFGVVLWELATYGLSPYPGIELHDVYHILEKGYRMDRPEGCPEIVYGIMLQCWQWDPLLRPSFAQLYS 500

[Close]

BLAST of Protein tyrosine kinase vs. Planmine SMEST
Match: SMESG000044603.1 (SMESG000044603.1)

HSP 1 Score: 129.028 bits (323), Expect = 1.399e-29
Identity = 100/332 (30.12%), Postives = 157/332 (47.29%), Query Frame = 3

Query:  564 SNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANF-------------------RIGQSQK---QVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFR--SYSILERTDTNDRK--DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDL-KLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEP 1478
            S+  T+S  +  + +  LI ++QLT   II  G F  +Y   +                   +I Q       V+VK +  +   S+  E ++E  V   +DHP  +++  + L   + KL+T+ + + SLL+ +Q   S I    +T   +  QI+  M YLE K IIH  L +RNVL+    Q+KITD GL +   YS  +      R    W+A E I     +  SD+W++GV LWEM+SYG+ P +  ++      L K   L QP +CS   ++I+  CW   P  RP+F +L   F          ++  P++    + ED NEP
Sbjct:  943 SDTGTNSGVLPNMATLLLITESQLTRQEIIGSGAFGIVYKGIWQPNIDAIDKSNSFLKRNISKISQDSSIKLNVAVKILTDISDPSNNREILEEAKVMASVDHPCCLRILAVCLT-AHPKLITQFMPLGSLLEFVQRNRSLINS--ITLLIWAKQIASGMEYLESKGIIHCDLAARNVLIQSPRQVKITDFGLAKMLDYSQQQYQFKGGRMPIKWLAVECIRNRIFSSKSDVWSYGVTLWEMFSYGEKPFADIKAYDILEHLEKGQRLNQPKICSIDAYTILVQCWLVDPDARPSFTELRKTFE--------MMSSNPNRYLLVQDEDSNEP 1263

[Close]

BLAST of Protein tyrosine kinase vs. Planmine SMEST
Match: SMESG000044603.1 (SMESG000044603.1)

HSP 1 Score: 129.028 bits (323), Expect = 1.408e-29
Identity = 100/332 (30.12%), Postives = 158/332 (47.59%), Query Frame = 3

Query:  564 SNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANF-------------------RIGQSQK---QVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDDQNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEKRIIHGHLTSRNVLVYPDNQIKITDAGLFR--SYSILERTDTNDRK--DWIAPEIINGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDL-KLHYLFQPDLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQIPSHRSEDFNEP 1478
            S+  T+S  +  + +  LI ++QLT   II  G F  +Y   +                   +I Q       V+VK +  +   S+  E ++E  V   +DHP  +++  + L   + KL+T+ + + SLL+ +Q   S I  + +T   +  QI+  M YLE K IIH  L +RNVL+    Q+KITD GL +   YS  +      R    W+A E I     +  SD+W++GV LWEM+SYG+ P +  ++      L K   L QP +CS   ++I+  CW   P  RP+F +L   F          ++  P++    + ED NEP
Sbjct:  920 SDTGTNSGVLPNMATLLLITESQLTRQEIIGSGAFGIVYKGIWQPNIDAIDKSNSFLKRNISKISQDSSIKLNVAVKILTDISDPSNNREILEEAKVMASVDHPCCLRILAVCLT-AHPKLITQFMPLGSLLEFVQRNRSLI--NSITLLIWAKQIASGMEYLESKGIIHCDLAARNVLIQSPRQVKITDFGLAKMLDYSQQQYQFKGGRMPIKWLAVECIRNRIFSSKSDVWSYGVTLWEMFSYGEKPFADIKAYDILEHLEKGQRLNQPKICSIDAYTILVQCWLVDPDARPSFTELRKTFE--------MMSSNPNRYLLVQDEDSNEP 1240

The following BLAST results are available for this feature:

BLAST of Protein tyrosine kinase vs. Ensembl Human
BLAST of Protein tyrosine kinase vs. Ensembl Celegans
BLAST of Protein tyrosine kinase vs. Ensembl Fly
BLAST of Protein tyrosine kinase vs. Ensembl Zebrafish
BLAST of Protein tyrosine kinase vs. Ensembl Xenopus
BLAST of Protein tyrosine kinase vs. Ensembl Mouse
BLAST of Protein tyrosine kinase vs. UniProt/SwissProt
BLAST of Protein tyrosine kinase vs. TrEMBL
BLAST of Protein tyrosine kinase vs. Ensembl Cavefish
BLAST of Protein tyrosine kinase vs. Ensembl Sea Lamprey
BLAST of Protein tyrosine kinase vs. Ensembl Yeast
BLAST of Protein tyrosine kinase vs. Ensembl Nematostella
BLAST of Protein tyrosine kinase vs. Ensembl Medaka
BLAST of Protein tyrosine kinase vs. Planmine SMEST

BLAST of Protein tyrosine kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TNK2	8.678e-42	28.43	tyrosine kinase non receptor 2 [Source:HGNC Symbol...	[more]
TNK2	2.354e-40	28.05	tyrosine kinase non receptor 2 [Source:HGNC Symbol...	[more]
TNK2	2.473e-40	28.43	tyrosine kinase non receptor 2 [Source:HGNC Symbol...	[more]
TNK2	2.489e-40	28.43	tyrosine kinase non receptor 2 [Source:HGNC Symbol...	[more]
TNK2	2.506e-40	28.43	tyrosine kinase non receptor 2 [Source:HGNC Symbol...	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ark-1	3.895e-65	28.91	Ack-related non-receptor tyrosine kinase [Source:...	[more]
ark-1	4.045e-65	28.91	Ack-related non-receptor tyrosine kinase [Source:...	[more]
csk-1	8.989e-33	29.84	Tyrosine-protein kinase csk-1 [Source:UniProtKB/S...	[more]
csk-1	8.989e-33	29.84	Tyrosine-protein kinase csk-1 [Source:UniProtKB/S...	[more]
csk-1	1.764e-32	29.84	Tyrosine-protein kinase csk-1 [Source:UniProtKB/S...	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ack-like	7.475e-77	30.91	gene:FBgn0263998 transcript:FBtr0330329	[more]
Ack-like	7.924e-77	30.91	gene:FBgn0263998 transcript:FBtr0330331	[more]
Ack-like	2.982e-76	30.91	gene:FBgn0263998 transcript:FBtr0330330	[more]
Ack-like	3.336e-76	30.76	gene:FBgn0263998 transcript:FBtr0330332	[more]
Ack	3.569e-37	29.21	gene:FBgn0028484 transcript:FBtr0073211	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tnk2b	1.762e-40	28.11	tyrosine kinase, non-receptor, 2b [Source:ZFIN;Acc...	[more]
tnk2a	4.211e-38	29.86	tyrosine kinase, non-receptor, 2a [Source:ZFIN;Acc...	[more]
tnk2a	1.029e-37	29.62	tyrosine kinase, non-receptor, 2a [Source:ZFIN;Acc...	[more]
matk	1.530e-37	32.36	megakaryocyte-associated tyrosine kinase [Source:Z...	[more]
matk	2.225e-37	32.36	megakaryocyte-associated tyrosine kinase [Source:Z...	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
arfgef3	1.081e-38	30.82	ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE...	[more]
arfgef3	1.123e-38	30.82	ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE...	[more]
arfgef3	1.579e-38	30.82	ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE...	[more]
arfgef3	1.617e-38	30.82	ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE...	[more]
arfgef3	1.713e-38	30.82	ARFGEF family member 3 [Source:Xenbase;Acc:XB-GENE...	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tnk2	4.741e-42	29.10	tyrosine kinase, non-receptor, 2 [Source:MGI Symbo...	[more]
Tnk2	5.111e-42	29.10	tyrosine kinase, non-receptor, 2 [Source:MGI Symbo...	[more]
Tnk2	5.346e-42	29.10	tyrosine kinase, non-receptor, 2 [Source:MGI Symbo...	[more]
Tnk2	5.439e-42	29.10	tyrosine kinase, non-receptor, 2 [Source:MGI Symbo...	[more]
Tnk2	5.550e-42	29.10	tyrosine kinase, non-receptor, 2 [Source:MGI Symbo...	[more]

BLAST of Protein tyrosine kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9I7F7\|ACKL_DROME	7.493e-76	30.91	Activated Cdc42 kinase-like OS=Drosophila melanoga...	[more]
sp\|G5EBZ8\|ARK1_CAEEL	4.954e-64	28.91	Ack-related non-receptor tyrosine kinase OS=Caenor...	[more]
sp\|O54967\|ACK1_MOUSE	3.984e-41	29.10	Activated CDC42 kinase 1 OS=Mus musculus OX=10090 ...	[more]
sp\|Q5U2X5\|ACK1_RAT	5.512e-41	28.91	Activated CDC42 kinase 1 OS=Rattus norvegicus OX=1...	[more]
sp\|Q07912\|ACK1_HUMAN	1.188e-39	28.43	Activated CDC42 kinase 1 OS=Homo sapiens OX=9606 G...	[more]

BLAST of Protein tyrosine kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A5K3EHV7	3.127e-80	31.61	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A2S2PCZ7	3.437e-79	31.09	Tyrosine-protein kinase PR2 (Fragment) OS=Schizaph...	[more]
K7IMP9	4.397e-79	31.24	Uncharacterized protein OS=Nasonia vitripennis OX=...	[more]
A0A5K3EG80	8.493e-79	30.96	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A5K3EG94	1.141e-78	30.96	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tnk2b	1.912e-39	28.49	tyrosine kinase non receptor 2 [Source:NCBI gene;A...	[more]
tnk2b	1.914e-39	28.49	tyrosine kinase non receptor 2 [Source:NCBI gene;A...	[more]
tnk2b	2.245e-39	28.49	tyrosine kinase non receptor 2 [Source:NCBI gene;A...	[more]
tnk2b	2.408e-39	28.49	tyrosine kinase non receptor 2 [Source:NCBI gene;A...	[more]
tnk1	6.294e-36	26.38	tyrosine kinase non receptor 1 [Source:NCBI gene;A...	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
txk	1.410e-30	30.74	TXK tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-1305...	[more]
fgfr2	2.037e-30	28.16	fibroblast growth factor receptor 2 [Source:NCBI g...	[more]
frk	1.309e-29	28.28	fyn-related Src family tyrosine kinase [Source:ZFI...	[more]
abl1	2.775e-29	28.01	c-abl oncogene 1, non-receptor tyrosine kinase [So...	[more]
frk	6.443e-29	28.18	fyn-related Src family tyrosine kinase [Source:ZFI...	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
SPS1	3.163e-16	25.66	Putative protein serine/threonine kinase; localize...	[more]
TPK3	3.085e-14	27.31	cAMP-dependent protein kinase catalytic subunit; p...	[more]
IPL1	1.582e-13	30.82	Aurora kinase of chromosomal passenger complex; me...	[more]
MKK1	6.490e-13	24.32	MAPKK involved in the protein kinase C signaling p...	[more]
STE11	2.496e-12	29.81	Signal transducing MEK kinase; involved in pheromo...	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO41796	2.927e-39	31.58	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47802	3.020e-37	26.56	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47195	5.970e-32	28.84	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49126	2.002e-30	29.82	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33736	1.018e-29	27.76	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Protein tyrosine kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tnk2b	7.408e-43	30.70	activated CDC42 kinase 1 [Source:NCBI gene;Acc:101...	[more]
tnk2b	7.576e-43	30.70	activated CDC42 kinase 1 [Source:NCBI gene;Acc:101...	[more]
tnk2b	8.103e-43	30.70	activated CDC42 kinase 1 [Source:NCBI gene;Acc:101...	[more]
tnk2a	9.917e-42	31.09	activated CDC42 kinase 1 [Source:NCBI gene;Acc:101...	[more]
tnk2a	1.122e-41	31.09	activated CDC42 kinase 1 [Source:NCBI gene;Acc:101...	[more]

BLAST of Protein tyrosine kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000064360.1	0.000e+0	99.75	SMESG000064360.1	[more]
SMESG000051839.1	1.081e-36	31.79	SMESG000051839.1	[more]
SMESG000056885.1	5.377e-30	34.51	SMESG000056885.1	[more]
SMESG000044603.1	1.399e-29	30.12	SMESG000044603.1	[more]
SMESG000044603.1	1.408e-29	30.12	SMESG000044603.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30008072 ID=SMED30008072|Name=Protein tyrosine kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=4526bp
ATTATAAAGTAAAAATTAATTCATTATTTTCTTTATATTTTAAAAAATGA
TAATATTACTGTGATATCCTATATTATAGATTTTACAATCAAATTATGCT
CACAGACAATAATTCGAGCTCGTTTAGAAATGGATACGAATTTAATAATA
ATGGATCGGTTTCAAGCAACAGTACTGGAATGGATAACTTGCTGGAATTT
CTCAAAGAAGCCCAGCTGGATCATTATTTTGATGAGTTAAATCTAAAATT
AAAAATTCGTTTTACTGCCCAACTGAAATATGTTGACGAAATTGACCTTT
TATCCATCGGCATGACCCGTCCAGAAATGAGGCGTCTGAAAAAATATTTC
GAAAAAGAATTTCCACAAACAGCCATGGGAAAAATAAAAAAGAAACTATC
TAGAAGTACTTCAAATCGTTCTACATCAGTTCCTAGGCCACAAGATTTAT
CAGGTCGACTTAATTCCTTTTCAGTTCGAATGAATGGAAATGGGCCATCG
AGATCTCCAATAGGAAGTGATGATTTAACCACAGTAGCCAGTGTGACAAA
TTTTTCTATTGCGAGCAACGGAACAACAGACTCTTATGATATCAGACAAT
TGGGGAGTAAACATCTCATTTTACAAAACCAATTAACAATAGGAGCAATA
ATAAAGCATGGAGAATTCGCAGATATTTATCATGCTAATTTCCGTATAGG
TCAGTCTCAGAAACAAGTTTCTGTAAAATTTATCAATAAAGTACACTTGA
AAAGTGATTTGAATGAATTTATCAAAGAAATGTTTGTTCAATGTTATCTT
GATCACCCAAATGTTATTAAGCTCTTTGGGATCAGTCTTGATGATCAAAA
CATTAAATTAGTAACCGAGCAACTAAATGTCAGTTCTCTTCTGAAATGCC
TTCAAGATCCGAATTCAAAAATCACTTATTCAATTCTGACTTTTCACAAT
TTTACCATTCAGATCAGTGAGGCAATGACGTATTTGGAAGAGAAGCGTAT
CATTCACGGTCATTTAACCAGCCGTAATGTTCTGGTCTATCCTGATAACC
AGATAAAAATCACAGATGCTGGACTGTTTCGTAGTTATTCAATTCTCGAA
AGAACAGACACTAACGATCGAAAAGATTGGATTGCACCCGAAATAATTAA
TGGGTCTCAACCAACGTTATCTTCGGATATCTGGGCTTTTGGGGTTTTGC
TGTGGGAAATGTATAGTTATGGTCAGTATCCGATTTCAATGAGCGAATCT
CTTGGTAGTCAATCTGACTTGAAACTTCATTATTTGTTTCAACCAGATTT
ATGTTCAAACATGGTTTTTAGTATAATAACATCGTGTTGGAGTGAGCAAC
CTCGGGATCGTCCAACCTTTTATCAACTCACAAGCAATTTCAATAAACTC
ATCCCAGAACAATTGATTGCTTTAACGGATGGGCCGGATCAAATTCCTTC
ACATAGATCAGAAGATTTTAATGAACCCAGTGATGGATCGTATTCATCTT
TAACAGAATTGCAAATGCTTTATTACAACAGGGGTGACACCGTCATAGTC
CTGGACAGAAATATGAATCTCTATAAAGATTTTTGGAAGGGATGTCTCCT
CAATGGAGAATCTGGGTATTTTAAATGGTCAAACATGCGATCAGTTGGTG
TAAATTCGACACCGATGAATGAAACCGTGCAACACATTGTCAATCTCAGA
AATTCACAAAGTCCAACCAATTCTGTTCGATCTTCGGGTCGAAGTCGAAG
CGTTGGAGAAGCCTTTGCAAAATTAAAAATTATTGGAAGAGGAAAATCAG
ATAAGAAACATCGAACAGGTCGAATATCAATTGACATGATCAGTGCACCA
CAGAAAGATTTCCGGCACATTGGCCATGTTAGCAACAACGGTGATGTATT
CGGCGACGTGACATCATTATACACTAGTACTGCACAACAAAAAATCAGAT
CTGGTACAATTTCCGTTTGTTCCAAACTGAATACCTCAACCAGTCTTTCT
GAGGCCAGTAGTGTCATATCGACTTCCACTTTGAATGCAGCTGGAGATGA
TACGCCTCCTTATGCCACAATCGATAATGAAACCTCTAAAACCCTTTCCG
AAAAGCATTCTTCTAAGCCGAATCAGTCTAATGTTTTAATTCCGCCACCG
TTGCCACCGACAAGGAGCTATTCAGAGGATGAAGTCGATTCTAGTTGCCT
CATGAACGATTTGGAGTTATCAAATGAGTTTTCTCTTTGCAATGATGGCT
TTTCCTTATTCAATGAATTATCTAAACAGTGGGATATCCAATGCTCATGC
CTAGATTCAGAAGCTACACCGACATCAGATAGCAAAGTCCACATATCTGA
AACCAAGTCATCATTAAGCAGTGATTGTCCTACTATCATAACATTCGATA
GTTCCATGGAAAGTCCAGTTACCAGAAAATCTGAAAACATTTCTGAGACT
TCAGAGGTTGAAAAACCGCCAAATCGACCCATGAAGATTCCGATAACAAG
CTCGAATTCGGTTTCTTCTCCAACTTTCAAGGCATCCCTTGGTAATCATC
ATAGTATTCGTTCTTCTAGTTTCTTCACGAAAATTCGAACTCTTGGCAAC
GGAAAGACTTCCAAATCTAAAGAGATTCCTTCTCCGACAGATTTTACACA
AACCATCCCATCTCCACTGTATGCCAAAATAAAAAAACCGGGCAAGATCA
AAAAGCAAAAAGAAACTAATTCTAAGAAAAATATTATCAGCCACCCGATT
CTAATATCTGCCCCAGTTGTCACATCAGTTAATATTCCCGAGGAAAATTA
TTTGGATTGTTCAAGTGAAGTTTCCAGTCTTCAACCAAGTCCTAGAGAAT
CTGTAATTGGAACACCGTATTCTTATGCATTCAATATGAATGCAAATCAA
GACCAGTCGGCTTTATTGAGTAGGCAACATTCTAATGTAACTAGTTGTAC
CAAAATAACGAATGGTTCAACTACATCGGTTTCTCCGGCTTCATCTTTTG
TTTCTTTAACCTCAGCTCCGATCAGTAATTTACCCCAGAGTGGTGCAGCT
ATTCGTGCTATCAAGAAAGGAGATGGGGTTTTCAGAGCCACCGCAGTATC
GAACAGAAGAAGACCATCAGCCAGTGATCAGTTTCTAAATGATGGCACTT
TATCAAGAACTCGACAACCAAGCTTGCCTATGGTGTCCACTATGAACCGA
ATAAATAGTTCAACTATAGATAGGCGTCTATATTCAAGATCTGGAATTTC
TAATAATGACTTACTGGAATCCGTATTAGACTCGTCGGCAACCACCCCAA
TTGCCTCAGAACTGCCAGATTTACCGTATATTGACCTATCATTTGCACGC
CCTCCAACGGAAGATAAAATAAATCCGGTAGATGAGGATGATGCGTATAA
TTCTCTTCATTTCGGTTCAATTGGTTCCGACACGATCGAGACCCATTGTT
CCATTAAACTATCAGATTCTGCTTATGACCATCAAGACAGTTTAAAGGCA
AAGGAAAGCTCATTGTTTCAATTTTCAAAAAATTCAAACCCACCAAAATC
AGATTTGTCATTTTTCAACGAGAATCCTTTCTCTCTCTGTTTAGATTCAT
CGTCTACATTTAATAGTTACCAAATTCAAACTAACAAATTCACAAATTTT
GGTGAAAATGACGAAATTGCGTTGTAAACCCCGTTGACGCGTTGGTGCGT
TCATTAGATGATAGCTGCAGATATATAATGTTAATAATAAATTTTCTTTT
TAATTGACATCTTAACATTTTTTATGTGTGTTTGTAAGTTAATTTTCTAG
GAATATTTCAGCGGTGCGCGCCGCATCGTTGCATTTTGTTAGATGGATAT
TCTGTCCCGTGTTGTATTGTTGTTGTTGACAGTTGTTTTCGGTTGTTCAT
TTAACTTTTATTCCCTGATTGGAAGGTTTTGTATTATATTTTCTTTCGAC
TTTAGAATGTTGTGTTTATTTGCAAGTGTTTTTTTGTTCTGTTGAATAAG
TGGAAATTGATTTTTGTTTATATTTCATTTCATAAAACGTTCGGTTTTTA
TTTTCATTCGTAGTAAAAGAAGAATGAAAAGAGATTCGTTTTTTATTGGA
AATTTTATCGTGGAAATATTCAGGAATTGTGACAAAAATGTGATAAAAAT
TAATTTATTTCGAACTTTTTTTTATAAATTTGAGAGATGATAAATTACCT
GAGTAGTTTAACATATTCAATCTATCTATCTATCTTGTATGTGCTGCTGT
TTCTGTTGTTGTTGCTATTGCTGTTGCGGTTTCAGTTTCTTGTATAATAT
GTGTACATTAGTTAATACTGACTGGAGACGGATTTAGTGTCGTTGCGGTG
GAGTCTCATCATCAAACCGTTTGTCGATATTTTTTATTATTTTCCTATGA
TTTCGATGATATCAGCGCTGAAATAATAATAATGATTAATTTTTAAAATT
AATCGAGTTATGAGTGCAACAATTTAAACACATGAAATAAAAGTTTTGAC
TCAATAAAATATCTGTTGAAAAAAAA

protein sequence of SMED30008072-orf-1

>SMED30008072-orf-1 ID=SMED30008072-orf-1|Name=SMED30008072-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1194bp
MLTDNNSSSFRNGYEFNNNGSVSSNSTGMDNLLEFLKEAQLDHYFDELNL
KLKIRFTAQLKYVDEIDLLSIGMTRPEMRRLKKYFEKEFPQTAMGKIKKK
LSRSTSNRSTSVPRPQDLSGRLNSFSVRMNGNGPSRSPIGSDDLTTVASV
TNFSIASNGTTDSYDIRQLGSKHLILQNQLTIGAIIKHGEFADIYHANFR
IGQSQKQVSVKFINKVHLKSDLNEFIKEMFVQCYLDHPNVIKLFGISLDD
QNIKLVTEQLNVSSLLKCLQDPNSKITYSILTFHNFTIQISEAMTYLEEK
RIIHGHLTSRNVLVYPDNQIKITDAGLFRSYSILERTDTNDRKDWIAPEI
INGSQPTLSSDIWAFGVLLWEMYSYGQYPISMSESLGSQSDLKLHYLFQP
DLCSNMVFSIITSCWSEQPRDRPTFYQLTSNFNKLIPEQLIALTDGPDQI
PSHRSEDFNEPSDGSYSSLTELQMLYYNRGDTVIVLDRNMNLYKDFWKGC
LLNGESGYFKWSNMRSVGVNSTPMNETVQHIVNLRNSQSPTNSVRSSGRS
RSVGEAFAKLKIIGRGKSDKKHRTGRISIDMISAPQKDFRHIGHVSNNGD
VFGDVTSLYTSTAQQKIRSGTISVCSKLNTSTSLSEASSVISTSTLNAAG
DDTPPYATIDNETSKTLSEKHSSKPNQSNVLIPPPLPPTRSYSEDEVDSS
CLMNDLELSNEFSLCNDGFSLFNELSKQWDIQCSCLDSEATPTSDSKVHI
SETKSSLSSDCPTIITFDSSMESPVTRKSENISETSEVEKPPNRPMKIPI
TSSNSVSSPTFKASLGNHHSIRSSSFFTKIRTLGNGKTSKSKEIPSPTDF
TQTIPSPLYAKIKKPGKIKKQKETNSKKNIISHPILISAPVVTSVNIPEE
NYLDCSSEVSSLQPSPRESVIGTPYSYAFNMNANQDQSALLSRQHSNVTS
CTKITNGSTTSVSPASSFVSLTSAPISNLPQSGAAIRAIKKGDGVFRATA
VSNRRRPSASDQFLNDGTLSRTRQPSLPMVSTMNRINSSTIDRRLYSRSG
ISNNDLLESVLDSSATTPIASELPDLPYIDLSFARPPTEDKINPVDEDDA
YNSLHFGSIGSDTIETHCSIKLSDSAYDHQDSLKAKESSLFQFSKNSNPP
KSDLSFFNENPFSLCLDSSSTFNSYQIQTNKFTNFGENDEIAL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0030154	cell differentiation
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR000095	CRIB_dom
IPR000719	Prot_kinase_dom
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005102	signaling receptor binding
GO:0016301	kinase activity
GO:0016740	transferase activity

Vocabulary: **cellular component**
Term	Definition
GO:0005575	cellular_component
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PRINTS	PR00109	TYRKINASE	coord: 296..314 score: 47.53 coord: 360..382 score: 48.38 coord: 403..425 score: 35.48
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PFAM	PF07714	Pkinase_Tyr	coord: 181..431 e-value: 2.0E-56 score: 191.2
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 173..438 e-value: 7.3E-55 score: 187.8
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 98..117
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 96..117
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 772..792
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 663..696
None	No IPR available	PANTHER	PTHR24418	TYROSINE-PROTEIN KINASE	coord: 34..605
None	No IPR available	PANTHER	PTHR24418:SF295	LYN PROTO-ONCOGENE, SRC FAMILY TYROSINE KINASE	coord: 34..605
None	No IPR available	CDD	cd09539	SAM_TNK-like	coord: 30..89 e-value: 6.60639E-22 score: 88.0201
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 180..436 score: 31.071
IPR000095	CRIB domain	PROSITE	PS50108	CRIB	coord: 582..596 score: 7.866
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 173..435