Transient receptor potential cation channel subfamily V member

Overview
NameTransient receptor potential cation channel subfamily V member
Smed IDSMED30008067
Length (bp)711
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Transient receptor potential cation channel subfamily V member (SMED30008067) t-SNE clustered cells

Violin plots show distribution of expression levels for Transient receptor potential cation channel subfamily V member (SMED30008067) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Transient receptor potential cation channel subfamily V member (SMED30008067) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Transient receptor potential cation channel subfamily V member (SMED30008067) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30008067

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30008067SMESG000039339.1 dd_Smed_v4_22272_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30008067SMESG000039339.1 dd_Smed_v4_22272_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30008067SMESG000039339.1 dd_Smed_v4_22272_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30008067SMESG000039339.1 dd_Smed_v6_22272_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Human
Match: TRPV4 (transient receptor potential cation channel subfamily V member 4 [Source:HGNC Symbol;Acc:HGNC:18083])

HSP 1 Score: 59.6918 bits (143), Expect = 1.113e-9
Identity = 34/87 (39.08%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  IL V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  610 LLDLFKLTIGMGD--LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 694
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Human
Match: TRPV4 (transient receptor potential cation channel subfamily V member 4 [Source:HGNC Symbol;Acc:HGNC:18083])

HSP 1 Score: 59.6918 bits (143), Expect = 1.140e-9
Identity = 34/87 (39.08%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  IL V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  563 LLDLFKLTIGMGD--LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 647
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Human
Match: TRPV4 (transient receptor potential cation channel subfamily V member 4 [Source:HGNC Symbol;Acc:HGNC:18083])

HSP 1 Score: 59.3066 bits (142), Expect = 1.226e-9
Identity = 34/87 (39.08%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  IL V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  623 LLDLFKLTIGMGD--LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 707
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Human
Match: TRPV4 (transient receptor potential cation channel subfamily V member 4 [Source:HGNC Symbol;Acc:HGNC:18083])

HSP 1 Score: 59.3066 bits (142), Expect = 1.229e-9
Identity = 34/87 (39.08%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  IL V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  670 LLDLFKLTIGMGD--LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 754
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Human
Match: TRPV4 (transient receptor potential cation channel subfamily V member 4 [Source:HGNC Symbol;Acc:HGNC:18083])

HSP 1 Score: 59.3066 bits (142), Expect = 1.229e-9
Identity = 34/87 (39.08%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  IL V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  670 LLDLFKLTIGMGD--LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 754
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Celegans
Match: ocr-4 (Osm-9 and Capsaicin receptor-Related [Source:UniProtKB/TrEMBL;Acc:Q9N3Y9])

HSP 1 Score: 136.346 bits (342), Expect = 1.796e-36
Identity = 86/169 (50.89%), Postives = 118/169 (69.82%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVF--RRVNESLFHEP------LEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILI 602
            GF+ VGPFV+M+YK++  DL+RFF+IY++ ++GFSQA YV+F   + ++S   EP       E+ + MFIMSL EF   +EQ +  EH+V+GKI FVVYM+LVTLLL+NMLIAMM NTYT V+ N  EWLRQW+ IIL++EQSF    R +   +Y      G + +L+
Sbjct:  525 GFKSVGPFVLMLYKIIIRDLMRFFLIYLVIVVGFSQAFYVIFLGYKRSDSGNREPSIMSNVAESYVRMFIMSLTEFTVFFEQLEECEHTVIGKITFVVYMLLVTLLLINMLIAMMTNTYTEVSGNSLEWLRQWSAIILMMEQSFDPATRLRYQRRYGIRFDGGEKLVLL 693
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Celegans
Match: ocr-3 (Osm-9 and Capsaicin receptor-Related [Source:UniProtKB/TrEMBL;Acc:Q22374])

HSP 1 Score: 112.464 bits (280), Expect = 3.119e-28
Identity = 69/181 (38.12%), Postives = 113/181 (62.43%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVN----------------------ESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVL--GKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRR 590
              + VGPFV+M+YK++  D+LRF +IY  FL+GF+QA +V+F+                         E++  +  EA+M MFIMS+GEF  +Y+  +  + S+    K+ F+++ ++VT++L+N+LIAMM  TY  + E +KEW RQWA++IL++EQS S  ER   L +Y++P++  +R
Sbjct:  590 SLKFVGPFVLMVYKIIVRDMLRFLLIYSFFLMGFAQAFFVIFKSCERAEIAYQKAHNYTEDDEYIEKFENIMEDGWEAVMRMFIMSVGEFGALYKNLNECKSSIAPQSKVFFILFELIVTVMLLNLLIAMMTRTYEKIAETEKEWKRQWAQVILMLEQSSSASERLLSLYRYTRPIRSDKR 770
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Celegans
Match: ocr-1 (Osm-9 and Capsaicin receptor-Related [Source:UniProtKB/TrEMBL;Acc:G5EDR9])

HSP 1 Score: 99.3673 bits (246), Expect = 1.053e-23
Identity = 62/173 (35.84%), Postives = 103/173 (59.54%), Query Frame = 3 
Query:  129 LVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVN----------------ESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEH---SVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRR 590
             VGPFV+M+Y ++  DL+RF +IY IFL+GFSQ+ Y++F                     ++   P++AL+  FIM++GEF  +Y +    ++     +GK++FV++   V++L  N+LIAMM  TY  +   +KEW RQWA++IL++E   S   R+  L++Y++P    +R
Sbjct:  598 FVGPFVLMVYTIIATDLVRFAMIYSIFLVGFSQSFYLIFTSCERDSTAIKKIDPMGSEFNNIMENPVDALLRTFIMTIGEFSVLYREMSACDNFWMKWIGKLIFVIFETFVSILQFNLLIAMMTRTYETIFLTRKEWKRQWAQVILMLEMGLSPASRKMHLLRYTRPTGINKR 770
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Celegans
Match: osm-9 (Olfactory channel [Source:UniProtKB/TrEMBL;Acc:G5EBV8])

HSP 1 Score: 89.3521 bits (220), Expect = 2.993e-20
Identity = 60/167 (35.93%), Postives = 98/167 (58.68%), Query Frame = 3 
Query:  126 RLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNES-------------------LFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMV-NENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYS 566
            +L GPFV MIY M+ GD++RF II  IFL+ FSQ  Y V + ++                      ++   E  + +F  S+G ++  YE+F C+ +  L K LFV+YM ++ ++++N+LIAMMGNTYT V  + +K W +Q+A+I++V+E+S   +      ++YS
Sbjct:  520 KLTGPFVQMIYSMIAGDMIRFAIISAIFLVSFSQVFYFVGKDMDAKQKLEDTNPHACRISGYTIYTYNTFPETFITLFRASMGGYD--YEEFSCANYQALTKTLFVLYMFVMPIMMINILIAMMGNTYTTVIAQAEKAWRQQYAQIVMVLERSVGKERLAASQLEYS 684
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Celegans
Match: ocr-2 (Osm-9 and Capsaicin receptor-Related [Source:UniProtKB/TrEMBL;Acc:O61220])

HSP 1 Score: 87.0409 bits (214), Expect = 1.685e-19
Identity = 65/203 (32.02%), Postives = 108/203 (53.20%), Query Frame = 3 
Query:  126 RLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVF----RRVN----------------------------------------ESLFHEPLEALMGMFIMSLGEFEDIYEQFD-CSEHSV--LGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRA 593
            R VGPFV+M+Y ++  D+ RF +IY IFL+GFSQ+  ++F    R  N                                        E++   P+EA +  FI+++GEF  +Y     C  +++  +GK++F+++ + V+++  NMLIAMM  TY  + + Q E+ RQ A++IL++E S S +ER Q L+KYS+P    ++ 
Sbjct:  188 RFVGPFVLMVYTIIATDIFRFMLIYGIFLMGFSQSFSLIFLSCEREANVIKKLITDQSEASEGSDNKFNLTRQISAYDTAIVKNAEVFENVMQSPIEAFVRTFILTIGEFTVLYRNLALCPANTMVWIGKVVFILFELFVSIMQFNMLIAMMTRTYETIFQTQLEYKRQRAQVILMLELSLSPKERHQYLLKYSRPTGTNKKT 390
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Fly
Match: nan (gene:FBgn0036414 transcript:FBtr0089524)

HSP 1 Score: 148.288 bits (373), Expect = 1.764e-40
Identity = 89/213 (41.78%), Postives = 133/213 (62.44%), Query Frame = 3 
Query:   24 YSCIIRLNFMWLHMCFDTKADRKLLALL*QS*---------GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVF-----------RRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILI 602
            +SC + +   WL +   T+ D  +  ++  +          GF+ VGPFVVMIY+MV GDLLRF  IY++F++GFSQA Y++F           +    +    P+E+++ MF+MSL  F D Y     ++H    KILF ++M++V++LLVNMLIAMMGNTY  + E + EW RQWA+I+LV+E+S    ER +  M+YSQ + DGRRA+++
Sbjct:  560 FSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYFLFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAESNPMPSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFLFMVIVSVLLVNMLIAMMGNTYQKIAEIRNEWQRQWARIVLVVERSVPPAERLKNFMQYSQSMSDGRRALVL 772
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Fly
Match: nan (gene:FBgn0036414 transcript:FBtr0321258)

HSP 1 Score: 147.902 bits (372), Expect = 1.890e-40
Identity = 90/213 (42.25%), Postives = 133/213 (62.44%), Query Frame = 3 
Query:   24 YSCIIRLNFMWLHMCFDTKADRKLLALL*QS*---------GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHE-----------PLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILI 602
            +SC + +   WL +   T+ D  +  ++  +          GF+ VGPFVVMIY+MV GDLLRF  IY++F++GFSQA Y++F   +     E           P+E+++ MF+MSL  F D Y     ++H    KILF ++M++V++LLVNMLIAMMGNTY  + E + EW RQWA+I+LV+E+S    ER +  M+YSQ + DGRRA+++
Sbjct:  560 FSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYFLFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAESNPMPSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFLFMVIVSVLLVNMLIAMMGNTYQKIAEIRNEWQRQWARIVLVVERSVPPAERLKNFMQYSQSMSDGRRALVL 772
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Fly
Match: iav (gene:FBgn0086693 transcript:FBtr0070969)

HSP 1 Score: 115.931 bits (289), Expect = 3.310e-29
Identity = 66/154 (42.86%), Postives = 101/154 (65.58%), Query Frame = 3 
Query:  126 RLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFR---RVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTY-TMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPL 575
            RL GPFV MIY M+ GD+  F IIY I L GFSQA Y +++   +V  ++F+      M +F  +LG++   Y   + + +  L K +FV++MI V +LL+NMLIAMMGNTY T++ +++KEW++QWAKI++ +E++    + +  L  YS PL
Sbjct:  548 RLTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLYKGHPQVQSTMFNTYTSTWMALFQTTLGDYN--YPDLNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQADAKGYLEAYSIPL 699
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Zebrafish
Match: trpv4 (transient receptor potential cation channel, subfamily V, member 4 [Source:ZFIN;Acc:ZDB-GENE-030912-7])

HSP 1 Score: 61.2326 bits (147), Expect = 1.822e-10
Identity = 36/89 (40.45%), Postives = 55/89 (61.80%), Query Frame = 3 
Query:  282 EALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVN-ENQKEWLRQWAKIILVIEQSFSIQERR 545
            E L+ +F +++G   D+      +++  +  IL V Y+IL  +LL+NMLIA+MG T   V+ E++K W  QWA  IL IE+SF +  RR
Sbjct:  670 EFLLDLFKLTIG-IGDLDNMLKGAQYPAVFLILLVTYIILTFVLLLNMLIALMGETVGQVSKESKKIWKLQWATTILDIERSFPVCLRR 757
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Xenopus
Match: rab7a (RAB7A, member RAS oncogene family [Source:Xenbase;Acc:XB-GENE-483564])

HSP 1 Score: 62.3882 bits (150), Expect = 8.877e-11
Identity = 54/148 (36.49%), Postives = 85/148 (57.43%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQF-----DCSEHSV-LGKILFVVYM---ILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSI 533
            GF+++GPF +MI KM+ GDLLRF+ + ++ + GFS A Y +F+ V+++ F      LM +F          YE F       + + V L  I FVVY+   I+  LL++N+LIAMMG+TY  V + + E W  Q A   +++E+   +
Sbjct:  212 GFQMLGPFTIMINKMIFGDLLRFWWLMVVVIFGFSTAFYTIFQTVDQTQFGYFYSYLMSLF--------STYELFLNVINSPTNYDVDLPIIFFVVYVIFTIIANLLMLNILIAMMGDTYWRVAQERDELWRAQVAATTVMLEKKLPL 351
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Xenopus
Match: rab7a (RAB7A, member RAS oncogene family [Source:Xenbase;Acc:XB-GENE-483564])

HSP 1 Score: 62.3882 bits (150), Expect = 8.877e-11
Identity = 54/148 (36.49%), Postives = 85/148 (57.43%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQF-----DCSEHSV-LGKILFVVYM---ILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSI 533
            GF+++GPF +MI KM+ GDLLRF+ + ++ + GFS A Y +F+ V+++ F      LM +F          YE F       + + V L  I FVVY+   I+  LL++N+LIAMMG+TY  V + + E W  Q A   +++E+   +
Sbjct:  212 GFQMLGPFTIMINKMIFGDLLRFWWLMVVVIFGFSTAFYTIFQTVDQTQFGYFYSYLMSLF--------STYELFLNVINSPTNYDVDLPIIFFVVYVIFTIIANLLMLNILIAMMGDTYWRVAQERDELWRAQVAATTVMLEKKLPL 351
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Xenopus
Match: rab7a (RAB7A, member RAS oncogene family [Source:Xenbase;Acc:XB-GENE-483564])

HSP 1 Score: 61.6178 bits (148), Expect = 1.744e-10
Identity = 54/148 (36.49%), Postives = 85/148 (57.43%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQF-----DCSEHSV-LGKILFVVYM---ILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSI 533
            GF+++GPF +MI KM+ GDLLRF+ + ++ + GFS A Y +F+ V+++ F      LM +F          YE F       + + V L  I FVVY+   I+  LL++N+LIAMMG+TY  V + + E W  Q A   +++E+   +
Sbjct:  275 GFQMLGPFTIMINKMIFGDLLRFWWLMVVVIFGFSTAFYTIFQTVDQTQFGYFYSYLMSLF--------STYELFLNVINSPTNYDVDLPIIFFVVYVIFTIIANLLMLNILIAMMGDTYWRVAQERDELWRAQVAATTVMLEKKLPL 414
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Xenopus
Match: foxd3 (forkhead box D3 [Source:Xenbase;Acc:XB-GENE-487289])

HSP 1 Score: 56.225 bits (134), Expect = 1.235e-8
Identity = 33/87 (37.93%), Postives = 54/87 (62.07%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E  + +++  +  IL V Y+IL  +LL+NMLIA+MG T   V++  K+ W  QWA  IL IE+SF +  R+
Sbjct:  578 LLDLFKLTIGMGD--LEMINSAKYPAVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKLQWATTILDIERSFPVCMRK 662
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Xenopus
Match: foxd3 (forkhead box D3 [Source:Xenbase;Acc:XB-GENE-487289])

HSP 1 Score: 56.225 bits (134), Expect = 1.275e-8
Identity = 33/87 (37.93%), Postives = 54/87 (62.07%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E  + +++  +  IL V Y+IL  +LL+NMLIA+MG T   V++  K+ W  QWA  IL IE+SF +  R+
Sbjct:  591 LLDLFKLTIGMGD--LEMINSAKYPAVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKLQWATTILDIERSFPVCMRK 675
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Mouse
Match: Trpv4 (transient receptor potential cation channel, subfamily V, member 4 [Source:MGI Symbol;Acc:MGI:1926945])

HSP 1 Score: 58.5362 bits (140), Expect = 1.631e-9
Identity = 33/87 (37.93%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  +L V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  563 LLDLFKLTIGMGD--LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 647
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Mouse
Match: Trpv4 (transient receptor potential cation channel, subfamily V, member 4 [Source:MGI Symbol;Acc:MGI:1926945])

HSP 1 Score: 58.5362 bits (140), Expect = 1.653e-9
Identity = 33/87 (37.93%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  +L V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  610 LLDLFKLTIGMGD--LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 694
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Mouse
Match: Trpv4 (transient receptor potential cation channel, subfamily V, member 4 [Source:MGI Symbol;Acc:MGI:1926945])

HSP 1 Score: 58.5362 bits (140), Expect = 1.907e-9
Identity = 33/87 (37.93%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  +L V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  623 LLDLFKLTIGMGD--LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 707
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Mouse
Match: Trpv4 (transient receptor potential cation channel, subfamily V, member 4 [Source:MGI Symbol;Acc:MGI:1926945])

HSP 1 Score: 58.5362 bits (140), Expect = 1.929e-9
Identity = 33/87 (37.93%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  +L V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  670 LLDLFKLTIGMGD--LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 754
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Mouse
Match: Trpv4 (transient receptor potential cation channel, subfamily V, member 4 [Source:MGI Symbol;Acc:MGI:1926945])

HSP 1 Score: 58.5362 bits (140), Expect = 1.929e-9
Identity = 33/87 (37.93%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  +L V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  670 LLDLFKLTIGMGD--LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 754
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. UniProt/SwissProt
Match: sp|Q9HBA0|TRPV4_HUMAN (Transient receptor potential cation channel subfamily V member 4 OS=Homo sapiens OX=9606 GN=TRPV4 PE=1 SV=2)

HSP 1 Score: 59.3066 bits (142), Expect = 5.901e-9
Identity = 34/87 (39.08%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  IL V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  670 LLDLFKLTIGMGD--LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 754
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. UniProt/SwissProt
Match: sp|Q9EPK8|TRPV4_MOUSE (Transient receptor potential cation channel subfamily V member 4 OS=Mus musculus OX=10090 GN=Trpv4 PE=1 SV=1)

HSP 1 Score: 58.5362 bits (140), Expect = 1.349e-8
Identity = 33/87 (37.93%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  +L V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  670 LLDLFKLTIGMGD--LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 754
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. UniProt/SwissProt
Match: sp|Q9ERZ8|TRPV4_RAT (Transient receptor potential cation channel subfamily V member 4 OS=Rattus norvegicus OX=10116 GN=Trpv4 PE=1 SV=1)

HSP 1 Score: 58.151 bits (139), Expect = 1.467e-8
Identity = 33/87 (37.93%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E    +++ V+  +L V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  R+
Sbjct:  670 LLDLFKLTIGMGD--LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRK 754
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. UniProt/SwissProt
Match: sp|A0A1D5PXA5|TRPV4_CHICK (Transient receptor potential cation channel subfamily V member 4 OS=Gallus gallus OX=9031 GN=TRPV4 PE=1 SV=1)

HSP 1 Score: 58.151 bits (139), Expect = 1.474e-8
Identity = 34/87 (39.08%), Postives = 53/87 (60.92%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E  + +++  +  IL V Y+IL  +LL+NMLIA+MG T   V++  K  W  QWA  IL IE+SF +  RR
Sbjct:  656 LLDLFKLTIGMGD--LEMLESAKYPGVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPLFLRR 740
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. UniProt/SwissProt
Match: sp|Q9R186|TRPV6_RAT (Transient receptor potential cation channel subfamily V member 6 OS=Rattus norvegicus OX=10116 GN=Trpv6 PE=1 SV=2)

HSP 1 Score: 53.1434 bits (126), Expect = 7.162e-7
Identity = 45/141 (31.91%), Postives = 78/141 (55.32%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNE---SLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKE-WLRQWAKIILVIEQSFS 530
            GF+++GPF +MI KM+ GDL+RF  +  + +LGF+ A Y++F+  +      F++   AL   F + L    D    +D  +   +  I +  + I+ TLL++N+LIAMMG+T+  V   + E W  Q     +++E+   
Sbjct:  510 GFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFL-TIIDGPANYDV-DLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLERKLP 648
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. TrEMBL
Match: A0A077L8F9 (Transient receptor potential ion channel V a (Fragment) OS=Dugesia japonica OX=6161 GN=DjTRPVa PE=2 SV=1)

HSP 1 Score: 301.597 bits (771), Expect = 4.390e-100
Identity = 154/167 (92.22%), Postives = 158/167 (94.61%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVEEV 620
            GFRLVGPFVVMIYKMVRGDLLRF      F   FSQAMYVVFRRV+ESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHS+LGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVE++
Sbjct:  100 GFRLVGPFVVMIYKMVRGDLLRFLSFTSYFCWDFSQAMYVVFRRVDESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSILGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVEKI 266
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. TrEMBL
Match: A0A210R561 (Transient receptor potential cation channel subfamily V member 6 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT03652 PE=3 SV=1)

HSP 1 Score: 199.519 bits (506), Expect = 1.293e-55
Identity = 104/160 (65.00%), Postives = 131/160 (81.88%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAIL 599
            GF + GPFVVMIYKM++GDL RF IIY +F++GFSQAMY+VFR + ++ F +P EA+MGMF+MSLGEF D YE FD + ++ LGKI+F VYMI+VTLLLVNMLIAMMGNTY +VNE QKEW RQWAKI+LVIEQS + ++RR Q  KYSQP ++ R  ++
Sbjct:  560 GFPIFGPFVVMIYKMIKGDLFRFVIIYTVFIIGFSQAMYIVFRGIPDTPFSDPAEAVMGMFMMSLGEFGDYYESFDNTNYATLGKIVFFVYMIMVTLLLVNMLIAMMGNTYQLVNETQKEWFRQWAKILLVIEQSVTTEQRRIQQTKYSQPTKNDRALVI 719
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. TrEMBL
Match: A0A1S3IFS8 (transient receptor potential cation channel subfamily V member 5 OS=Lingula unguis OX=7574 GN=LOC106163936 PE=3 SV=1)

HSP 1 Score: 191.045 bits (484), Expect = 7.017e-52
Identity = 100/161 (62.11%), Postives = 132/161 (81.99%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILI 602
            GF++VGPFV MIYKM+ GDLLRFF IY++F++GFSQAMY+V+R  ++ +F    E++MGM IMSLGEF DIY+ FD + H ++GK+LF VYM+LVT+LLVNMLIAMMGNTYT++N  QKEWLRQ A I+LVIEQS + +ER++Q   YSQP+   RRA+++
Sbjct:  846 GFKIVGPFVAMIYKMIIGDLLRFFTIYLVFVMGFSQAMYIVYRGTDDPIFSHSTESIMGMIIMSLGEFGDIYDSFDNTLHPIMGKVLFFVYMVLVTVLLVNMLIAMMGNTYTLINSTQKEWLRQKAHIVLVIEQSVTTEERKRQQRIYSQPMGGDRRALVV 1006
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. TrEMBL
Match: C3Y5R4 (ANK_REP_REGION domain-containing protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_125475 PE=3 SV=1)

HSP 1 Score: 184.111 bits (466), Expect = 6.135e-50
Identity = 96/170 (56.47%), Postives = 129/170 (75.88%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESL----FHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVEE 617
            GF+LVGPFVVMIYKM++GD+LRF IIY +F++ FSQ M+V+FR    SL    F +P+E++MGM +MS GEF D+YE FD   H +L K +F+ YM LVT+LL+NMLIAMMGNTYT + E +KEWLRQWA+I+L++EQS S  + R+Q +KYSQPL    +A+  +  E+
Sbjct:  569 GFKLVGPFVVMIYKMLKGDILRFLIIYAVFVMAFSQVMFVLFRAARSSLTYNQFTDPVESMMGMIVMSFGEFSDMYETFDHIRHPILAKAVFLAYMSLVTILLINMLIAMMGNTYTSIQETRKEWLRQWAQIVLIMEQSLSSDQLRKQQLKYSQPLSSQNKAVDTSKTEQ 738
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. TrEMBL
Match: A0A2T7NKZ2 (ANK_REP_REGION domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_17649 PE=3 SV=1)

HSP 1 Score: 172.94 bits (437), Expect = 3.012e-46
Identity = 92/161 (57.14%), Postives = 126/161 (78.26%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILI 602
            GFR+VGP V MIYKMV+GDLLRFFIIY++ ++GFSQAM+++FR  ++S F+E   +++  F MSLG+F D Y+ FD +++ V+ KI+FVVYMI+ TLLL+NMLIAMMGNTY +V   QKEW RQWA+I+L++E S +   R QQ MKYSQP+   +RA ++
Sbjct:  477 GFRMVGPSVYMIYKMVKGDLLRFFIIYVVIVIGFSQAMFIMFRGEDKSSFNETAGSVLAQFSMSLGQFGDFYDDFDSAKYPVMAKIMFVVYMIMATLLLINMLIAMMGNTYELVTNTQKEWFRQWARIVLMMELSVTPSHRLQQQMKYSQPMDGNKRAFVV 637
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Cavefish
Match: trpv4 (transient receptor potential cation channel, subfamily V, member 4 [Source:ZFIN;Acc:ZDB-GENE-030912-7])

HSP 1 Score: 61.6178 bits (148), Expect = 1.365e-10
Identity = 36/87 (41.38%), Postives = 57/87 (65.52%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVN-ENQKEWLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G   D+ +    +++ V+  IL V Y+IL  +LL+NMLIA+MG T + V+ E++K W  QWA  IL IE+SF +  RR
Sbjct:  624 LLDLFKLTIGT-GDLDDLVQGAQYPVVFLILVVTYIILTFVLLLNMLIALMGETVSQVSKESKKIWKLQWATTILDIERSFPVCLRR 709
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Sea Lamprey
Match: trpv6 (transient receptor potential cation channel, subfamily V, member 6 [Source:ZFIN;Acc:ZDB-GENE-040624-12])

HSP 1 Score: 58.9214 bits (141), Expect = 1.781e-10
Identity = 51/134 (38.06%), Postives = 79/134 (58.96%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVF---RRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILV 512
            GF ++GPF +MI KM+ GDLLRF  + ++ LLG++ A ++ F   RR +   F      L  MF + LG   DI   +D  +  ++ K+++V YMI   LL+VN+LIAMMG+T+  V   + E  R   +++ V
Sbjct:  318 GFEMLGPFTIMIQKMLFGDLLRFCWLMLMVLLGYASAFHICFQLLRREDFLHFAGFETVLFTMFQLFLGLL-DIPIPYD-KQVPIIIKLVYVSYMIFAFLLMVNLLIAMMGDTHWRVAHERDELWRAQVRVVSV 449
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Nematostella
Match: EDO37108 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGQ7])

HSP 1 Score: 120.939 bits (302), Expect = 2.126e-31
Identity = 78/168 (46.43%), Postives = 115/168 (68.45%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFR-----RVNESLFHEPLEALMGMFIMSLGEFEDIYEQF--DCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILI 602
            GF+L GP+VVMIY+M++ D + FFIIY IF++GFSQAM++         V+E +F     + + + IMSLGEF D   Q     S + ++G  +F ++M+L  LL+VNMLIAMMGNTY  V+E +KEW RQWA+I+L IE+  +  +R + L KYS+P+  G+RA+++
Sbjct:  530 GFQLTGPYVVMIYQMLKRDFIIFFIIYGIFVIGFSQAMFLAVSGYLDDSVDEHMFARWFSSGLVLIIMSLGEFGDPLVQLVESDSPYKIIGLFVFFIFMVLGALLIVNMLIAMMGNTYQSVSETKKEWTRQWAQIVLDIERMLTPGKRLRLLHKYSEPV-GGQRALIM 696
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Medaka
Match: trpv4 (transient receptor potential cation channel subfamily V member 4 [Source:NCBI gene;Acc:101169862])

HSP 1 Score: 59.3066 bits (142), Expect = 6.462e-10
Identity = 35/87 (40.23%), Postives = 54/87 (62.07%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVN-ENQKEWLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E  + +++  +  IL V Y+IL  +LL+NMLIA+MG T   V+ E++K W  QWA  IL IE SF +  RR
Sbjct:  689 LLDLFKLTIGMGD--LEMINSAQYPEVFLILLVTYIILTFVLLLNMLIALMGETVGQVSKESKKIWKLQWATTILDIEHSFPVCLRR 773
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Medaka
Match: trpv4 (transient receptor potential cation channel subfamily V member 4 [Source:NCBI gene;Acc:101169862])

HSP 1 Score: 59.3066 bits (142), Expect = 6.774e-10
Identity = 35/87 (40.23%), Postives = 54/87 (62.07%), Query Frame = 3 
Query:  288 LMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVN-ENQKEWLRQWAKIILVIEQSFSIQERR 545
            L+ +F +++G  +   E  + +++  +  IL V Y+IL  +LL+NMLIA+MG T   V+ E++K W  QWA  IL IE SF +  RR
Sbjct:  619 LLDLFKLTIGMGD--LEMINSAQYPEVFLILLVTYIILTFVLLLNMLIALMGETVGQVSKESKKIWKLQWATTILDIEHSFPVCLRR 703
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Planmine SMEST
Match: SMESG000039339.1 (SMESG000039339.1)

HSP 1 Score: 302.368 bits (773), Expect = 2.283e-98
Identity = 166/166 (100.00%), Postives = 166/166 (100.00%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVEE 617
            GFRLVGPFVVMIYKMVRGDLLRFFIIYIIFLLGFSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVEE
Sbjct:  567 GFRLVGPFVVMIYKMVRGDLLRFFIIYIIFLLGFSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVEE 732
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Planmine SMEST
Match: SMESG000039339.1 (SMESG000039339.1)

HSP 1 Score: 274.248 bits (700), Expect = 1.214e-94
Identity = 152/152 (100.00%), Postives = 152/152 (100.00%), Query Frame = 3 
Query:  162 MVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVEE 617
            MVRGDLLRFFIIYIIFLLGFSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVEE
Sbjct:    1 MVRGDLLRFFIIYIIFLLGFSQAMYVVFRRVNESLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAILINTVEE 152
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Planmine SMEST
Match: SMESG000004138.1 (SMESG000004138.1)

HSP 1 Score: 115.931 bits (289), Expect = 1.955e-29
Identity = 68/158 (43.04%), Postives = 110/158 (69.62%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNE---SLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMV-NENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQD 581
            GF+L GPFV MI+KM++GDLLRF  IY+I L  F+QA + +F+ +++   + F     +LM +F M+ G+F+  YE+F  ++++ L  ++F  +MI V +LL+NMLIAMMGNTY MV + +QKEW+  WAKI++ +E+++  Q  +    +YS P+++
Sbjct:  268 GFKLTGPFVTMIFKMIKGDLLRFGTIYVIVLCAFTQAFFFLFKDIDKLSITTFKTFHGSLMTLFQMTFGKFK--YEEFKYTKYNQLVLLVFASFMIFVPILLLNMLIAMMGNTYQMVISRSQKEWISMWAKIVITLERTYGSQRLKSFQQEYSTPIRN 423
[Close]
BLAST of Transient receptor potential cation channel subfamily V member vs. Planmine SMEST
Match: SMESG000004138.1 (SMESG000004138.1)

HSP 1 Score: 114.775 bits (286), Expect = 5.358e-29
Identity = 68/158 (43.04%), Postives = 110/158 (69.62%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNE---SLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMV-NENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQD 581
            GF+L GPFV MI+KM++GDLLRF  IY+I L  F+QA + +F+ +++   + F     +LM +F M+ G+F+  YE+F  ++++ L  ++F  +MI V +LL+NMLIAMMGNTY MV + +QKEW+  WAKI++ +E+++  Q  +    +YS P+++
Sbjct:  625 GFKLTGPFVTMIFKMIKGDLLRFGTIYVIVLCAFTQAFFFLFKDIDKLSITTFKTFHGSLMTLFQMTFGKFK--YEEFKYTKYNQLVLLVFASFMIFVPILLLNMLIAMMGNTYQMVISRSQKEWISMWAKIVITLERTYGSQRLKSFQQEYSTPIRN 780
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BLAST of Transient receptor potential cation channel subfamily V member vs. Planmine SMEST
Match: SMESG000004138.1 (SMESG000004138.1)

HSP 1 Score: 114.775 bits (286), Expect = 5.836e-29
Identity = 68/158 (43.04%), Postives = 110/158 (69.62%), Query Frame = 3 
Query:  120 GFRLVGPFVVMIYKMVRGDXXXXXXXXXXXXXXXSQAMYVVFRRVNE---SLFHEPLEALMGMFIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNTYTMV-NENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQD 581
            GF+L GPFV MI+KM++GDLLRF  IY+I L  F+QA + +F+ +++   + F     +LM +F M+ G+F+  YE+F  ++++ L  ++F  +MI V +LL+NMLIAMMGNTY MV + +QKEW+  WAKI++ +E+++  Q  +    +YS P+++
Sbjct:  621 GFKLTGPFVTMIFKMIKGDLLRFGTIYVIVLCAFTQAFFFLFKDIDKLSITTFKTFHGSLMTLFQMTFGKFK--YEEFKYTKYNQLVLLVFASFMIFVPILLLNMLIAMMGNTYQMVISRSQKEWISMWAKIVITLERTYGSQRLKSFQQEYSTPIRN 776
The following BLAST results are available for this feature:
BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TRPV41.113e-939.08transient receptor potential cation channel subfam... [more]
TRPV41.140e-939.08transient receptor potential cation channel subfam... [more]
TRPV41.226e-939.08transient receptor potential cation channel subfam... [more]
TRPV41.229e-939.08transient receptor potential cation channel subfam... [more]
TRPV41.229e-939.08transient receptor potential cation channel subfam... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ocr-41.796e-3650.89Osm-9 and Capsaicin receptor-Related [Source:UniP... [more]
ocr-33.119e-2838.12Osm-9 and Capsaicin receptor-Related [Source:UniP... [more]
ocr-11.053e-2335.84Osm-9 and Capsaicin receptor-Related [Source:UniP... [more]
osm-92.993e-2035.93Olfactory channel [Source:UniProtKB/TrEMBL;Acc:G5... [more]
ocr-21.685e-1932.02Osm-9 and Capsaicin receptor-Related [Source:UniP... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
nan1.764e-4041.78gene:FBgn0036414 transcript:FBtr0089524[more]
nan1.890e-4042.25gene:FBgn0036414 transcript:FBtr0321258[more]
iav3.310e-2942.86gene:FBgn0086693 transcript:FBtr0070969[more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
trpv41.822e-1040.45transient receptor potential cation channel, subfa... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rab7a8.877e-1136.49RAB7A, member RAS oncogene family [Source:Xenbase;... [more]
rab7a8.877e-1136.49RAB7A, member RAS oncogene family [Source:Xenbase;... [more]
rab7a1.744e-1036.49RAB7A, member RAS oncogene family [Source:Xenbase;... [more]
foxd31.235e-837.93forkhead box D3 [Source:Xenbase;Acc:XB-GENE-487289... [more]
foxd31.275e-837.93forkhead box D3 [Source:Xenbase;Acc:XB-GENE-487289... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Trpv41.631e-937.93transient receptor potential cation channel, subfa... [more]
Trpv41.653e-937.93transient receptor potential cation channel, subfa... [more]
Trpv41.907e-937.93transient receptor potential cation channel, subfa... [more]
Trpv41.929e-937.93transient receptor potential cation channel, subfa... [more]
Trpv41.929e-937.93transient receptor potential cation channel, subfa... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9HBA0|TRPV4_HUMAN5.901e-939.08Transient receptor potential cation channel subfam... [more]
sp|Q9EPK8|TRPV4_MOUSE1.349e-837.93Transient receptor potential cation channel subfam... [more]
sp|Q9ERZ8|TRPV4_RAT1.467e-837.93Transient receptor potential cation channel subfam... [more]
sp|A0A1D5PXA5|TRPV4_CHICK1.474e-839.08Transient receptor potential cation channel subfam... [more]
sp|Q9R186|TRPV6_RAT7.162e-731.91Transient receptor potential cation channel subfam... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A077L8F94.390e-10092.22Transient receptor potential ion channel V a (Frag... [more]
A0A210R5611.293e-5565.00Transient receptor potential cation channel subfam... [more]
A0A1S3IFS87.017e-5262.11transient receptor potential cation channel subfam... [more]
C3Y5R46.135e-5056.47ANK_REP_REGION domain-containing protein OS=Branch... [more]
A0A2T7NKZ23.012e-4657.14ANK_REP_REGION domain-containing protein OS=Pomace... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
trpv41.365e-1041.38transient receptor potential cation channel, subfa... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
trpv61.781e-1038.06transient receptor potential cation channel, subfa... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO371082.126e-3146.43Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
trpv46.462e-1040.23transient receptor potential cation channel subfam... [more]
trpv46.774e-1040.23transient receptor potential cation channel subfam... [more]
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BLAST of Transient receptor potential cation channel subfamily V member vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000039339.12.283e-98100.00SMESG000039339.1[more]
SMESG000039339.11.214e-94100.00SMESG000039339.1[more]
SMESG000004138.11.955e-2943.04SMESG000004138.1[more]
SMESG000004138.15.358e-2943.04SMESG000004138.1[more]
SMESG000004138.15.836e-2943.04SMESG000004138.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008067 ID=SMED30008067|Name=Transient receptor potential cation channel subfamily V member|organism=Schmidtea mediterranea sexual|type=transcript|length=711bp
GCTTGAATTTGTTTTAATTAACGTATTCTTGTATAATTCGACTTAACTTT
ATGTGGTTGCATATGTGTTTTGACACTAAAGCAGATCGGAAACTCTTAGC
TTTATTATAACAAAGCTAAGGATTTCGATTAGTGGGCCCATTTGTGGTAA
TGATATACAAAATGGTTCGCGGTGATCTGTTAAGATTTTTCATTATCTAT
ATAATTTTCTTATTGGGATTTTCTCAAGCAATGTACGTGGTGTTCCGGCG
AGTAAATGAATCATTATTCCACGAACCTCTTGAGGCCTTGATGGGAATGT
TTATTATGTCACTGGGGGAGTTTGAAGATATATATGAGCAATTCGATTGT
TCAGAGCACAGCGTACTTGGAAAAATTTTGTTTGTCGTATATATGATACT
GGTAACGCTTCTTTTGGTTAATATGTTGATTGCTATGATGGGGAACACGT
ACACTATGGTTAATGAAAATCAAAAAGAATGGCTACGCCAGTGGGCAAAG
ATTATCCTTGTCATAGAACAGTCTTTTTCAATTCAAGAGCGACGTCAGCA
ATTAATGAAATATAGTCAACCCCTGCAAGATGGTCGAAGAGCTATCTTGA
TAAACACTGTGGAAGAAGTCTATTTTTTATTTCATTTTTTATAATGCATC
TTTTAAAGGATCAAGCGTAAATCTCTTTGAAAATTGAATTCCTTTCATGT
GATCACAGAAA
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protein sequence of SMED30008067-orf-1

>SMED30008067-orf-1 ID=SMED30008067-orf-1|Name=SMED30008067-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=165bp
MIYKMVRGDLLRFFIIYIIFLLGFSQAMYVVFRRVNESLFHEPLEALMGM
FIMSLGEFEDIYEQFDCSEHSVLGKILFVVYMILVTLLLVNMLIAMMGNT
YTMVNENQKEWLRQWAKIILVIEQSFSIQERRQQLMKYSQPLQDGRRAIL
INTVEEVYFLFHFL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR024862TRPV
IPR005821Ion_trans_dom
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: molecular function
TermDefinition
GO:0005216ion channel activity
Vocabulary: biological process
TermDefinition
GO:0055085transmembrane transport
GO:0006811ion transport
GO:0034220ion transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR005821Ion transport domainPFAMPF00520Ion_transcoord: 4..108
e-value: 1.1E-13
score: 51.0
NoneNo IPR availablePANTHERPTHR10582:SF28NANCHUNG, ISOFORM Bcoord: 1..155
NoneNo IPR availableSUPERFAMILYSSF81324Voltage-gated potassium channelscoord: 7..102
NoneNo IPR availableTMHMMTMhelixcoord: 72..94
NoneNo IPR availableTMHMMTMhelixcoord: 13..32
IPR024862Transient receptor potential cation channel subfamily VPANTHERPTHR10582TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEINcoord: 1..155