Protein kinase C
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30008057 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of Protein kinase C vs. Ensembl Human
Match: PRKCI (protein kinase C iota [Source:HGNC Symbol;Acc:HGNC:9404]) HSP 1 Score: 684.485 bits (1765), Expect = 0.000e+0 Identity = 332/628 (52.87%), Postives = 424/628 (67.52%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCG-----EDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S +++K Y + IT S++++ L E+ +C + FTMKWID+EGDPCT+++Q+EL+EA RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG ++ +P QS + S+ A ++ I Y E L QV + K + + +G +GL DF+LL V+GRGSYAKV V K T +IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LK LNKDP +RL C P + F D Q H FFR ++WD + K++ PPF+P ++ + L NFD FT+EPV TPDD + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 23 SHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHA-----------------QTVIPYNPSSHESLDQVGEEKEAMNTRE-------------------------------------SGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
BLAST of Protein kinase C vs. Ensembl Human
Match: PRKCZ (protein kinase C zeta [Source:HGNC Symbol;Acc:HGNC:9412]) HSP 1 Score: 660.603 bits (1703), Expect = 0.000e+0 Identity = 333/624 (53.37%), Postives = 421/624 (67.47%), Query Frame = 3
Query: 45 IKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGE--DFNLPNYQSQI--KSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
++LK Y + IT ++A+ T+++L E+ +C L T+KW+D EGDPCT+++QMEL+EA RL +D +++HVFPS P PG+PC GED +YRRGA+RW+K Y GH F AKRFN+ A C C +RIWGL +QG RC C+LL+HKRC LV C + D +P+ + + K+ A + E GI Y+ S+ + +KD DL+ P +D G +G +GL DF+L+ V+GRGSYAKV V K +IYAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+P + F D ++HAFFR ++WD L K+ PPF+P++T D L NFD FT EPV TPDD+ I +IDQSEFEGFEYINPLLL+TEE+V
Sbjct: 16 VRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIA----YISSSRKH--------DSIKDDSEDLK--------------------------------PVIDGMDGIKISQG-LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592
BLAST of Protein kinase C vs. Ensembl Human
Match: PRKCZ (protein kinase C zeta [Source:HGNC Symbol;Acc:HGNC:9412]) HSP 1 Score: 565.459 bits (1456), Expect = 0.000e+0 Identity = 291/529 (55.01%), Postives = 357/529 (67.49%), Query Frame = 3
Query: 330 DLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGE--DFNLPNYQSQI--KSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
D +YRRGA+RW+K Y GH F AKRFN+ A C C +RIWGL +QG RC C+LL+HKRC LV C + D +P+ + + K+ A + E GI Y+ S+ + +KD DL+ P +D G +G +GL DF+L+ V+GRGSYAKV V K +IYAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+P + F D ++HAFFR ++WD L K+ PPF+P++T D L NFD FT EPV TPDD+ I +IDQSEFEGFEYINPLLL+TEE+V
Sbjct: 7 DESIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIA----YISSSRKH--------DSIKDDSEDLK--------------------------------PVIDGMDGIKISQG-LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 488
BLAST of Protein kinase C vs. Ensembl Human
Match: PRKCZ (protein kinase C zeta [Source:HGNC Symbol;Acc:HGNC:9412]) HSP 1 Score: 494.967 bits (1273), Expect = 4.163e-170 Identity = 238/363 (65.56%), Postives = 284/363 (78.24%), Query Frame = 3
Query: 816 PPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
P +D G +G +GL DF+L+ V+GRGSYAKV V K +IYAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+P + F D ++HAFFR ++WD L K+ PPF+P++T D L NFD FT EPV TPDD+ I +IDQSEFEGFEYINPLLL+TEE+V
Sbjct: 50 PVIDGMDGIKISQG-LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
BLAST of Protein kinase C vs. Ensembl Human
Match: PRKCZ (protein kinase C zeta [Source:HGNC Symbol;Acc:HGNC:9412]) HSP 1 Score: 409.453 bits (1051), Expect = 9.738e-138 Identity = 195/295 (66.10%), Postives = 233/295 (78.98%), Query Frame = 3
Query: 816 PPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWD 1700
P +D G +G +GL DF+L+ V+GRGSYAKV V K +IYAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+P + F D ++HAFFR ++WD
Sbjct: 46 PVIDGMDGIKISQG-LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWD 337
BLAST of Protein kinase C vs. Ensembl Celegans
Match: pkc-3 (Protein kinase C-like 3 [Source:UniProtKB/Swiss-Prot;Acc:Q19266]) HSP 1 Score: 461.455 bits (1186), Expect = 1.008e-154 Identity = 223/359 (62.12%), Postives = 275/359 (76.60%), Query Frame = 3
Query: 837 GTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSN--FDDFQNHAFFRG-LNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
G G K + L DF LL V+GRGSYAKV Q E+ T++IYA+K+IKKE + +DI+WVQTEK VFE ASN+PFLVGLHSCFQT SRL +VIEFV GGDLM+HMQ++ ++PEEHA+FY+ EI LAL+FLH R IIYRDLKLDNVL+D +GH+KLTDYGMCKE I+ +TFCGTPNYIAPEILR + YG SVDWW+LGVLMFEM+AG SP+ G EENTEDYLF +IL + IRIPRS+S +AS ILKG LNKDPT+RL CK N D + H FFRG ++W+ L K + PP+ P + DRDLT+FD FTDE +PD+ I++IDQSEF+GFEY+NPL ++ E++V
Sbjct: 240 GNGSSKWAVSLNDFRLLTVIGRGSYAKVVQAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYPFLVGLHSCFQTESRLFFVIEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRGIIYRDLKLDNVLIDAEGHIKLTDYGMCKENIKDGDLTSTFCGTPNYIAPEILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIVGMQ-NSEENTEDYLFQIILERQIRIPRSLSVRASGILKGFLNKDPTERLGCKLDINEGLRDMKEHQFFRGFIDWEALEQKAVAPPYHPAVESDRDLTHFDHQFTDELPQLSPDNPDVIARIDQSEFDGFEYVNPLQMSREDSV 597 HSP 2 Score: 179.104 bits (453), Expect = 4.943e-48 Identity = 79/179 (44.13%), Postives = 110/179 (61.45%), Query Frame = 3
Query: 27 MHESALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPN 563
+ E IKLK + + + + D + C + T+KWID++GDP +I +QMELDEA+R ++++AE+ +HVF P PG+PCQGED VYRRGA+RWKK Y GH+F AKR N+ +CF C D IWG+G+QG RC CRL +HK+C + V+ CG+ PN
Sbjct: 7 LEEDGDIKLKTRFQGQVVVLYARPPLILDDFFALLKDACKQHKKQDITVKWIDEDGDPISIDSQMELDEAVRCLNSSQEAELNIHVFVGKPELPGLPCQGEDKTVYRRGARRWKKIYLYNGHRFQAKRLNRRIQCFICHDYIWGIGRQGFRCVDCRLCVHKKCHRHVRTHCGQALQGPN 185
BLAST of Protein kinase C vs. Ensembl Celegans
Match: pkc-1 (Protein kinase C-like 1B [Source:UniProtKB/Swiss-Prot;Acc:P34885]) HSP 1 Score: 355.91 bits (912), Expect = 1.434e-113 Identity = 199/503 (39.56%), Postives = 280/503 (55.67%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRK------GKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDD-FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINP 1877
H+FS + + C +C ++GL QGL+C TC+L N + + N+A N GI E +LG D K +R+ + ++ +T++ + S+ S L D G T R G + + DF + V+G+GS+ KV E K T ++YA+K++KK+ I DD+E EK + A+ HPFL LHS FQT RL +V+E+VNGGDLM+ +QR + E A+FYAAE+ AL FLHR +IYRDLKLDN+L+D +GH +L D+GMCKEGI D +TFCGTP+YIAPEIL+ YG SVDWW+LGVLM+EM+AG QP P E + ED LF IL + P +S +A +ILK + K+ +RL C S +D + H FFR ++WD L ++++PPF+P++ RD NFD FT E + TP D + + I+Q EF GF +INP
Sbjct: 162 HRFSVHSYKRPTFCDHCGSMLYGLINQGLQCSTCKL---------------------NVHKRCQRNVA-----NNCGINAKQMAAE---------LAQLGLTGD-KMSIRS---KKKPSIMTDTSTDISGSSNSENSGYLQQISEDDSGTTSSRSASKVPGGTLSIHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAG-----QP----PFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFFREIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAVVRAINQDEFRGFSFINP 616 HSP 2 Score: 64.3142 bits (155), Expect = 2.100e-10 Identity = 29/65 (44.62%), Postives = 42/65 (64.62%), Query Frame = 3
Query: 345 RRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
RRGA R +K + + GHKF A + C +CK+ IWG+G+QG +C C +++HKRC + V KC
Sbjct: 70 RRGAMR-RKIHEVTGHKFMALFLRQPTFCAHCKEFIWGIGKQGYQCQICTVVVHKRCHEDVVWKC 133
BLAST of Protein kinase C vs. Ensembl Celegans
Match: pkc-1 (Protein kinase C-like 1B [Source:UniProtKB/Swiss-Prot;Acc:P34885]) HSP 1 Score: 351.673 bits (901), Expect = 5.167e-111 Identity = 198/503 (39.36%), Postives = 278/503 (55.27%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRK------GKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDD-FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINP 1877
H+FS + + C +C ++GL QGL+C T C+ V +C + A N GI E +LG D K +R+ + ++ +T++ + S+ S L D G T R G + + DF + V+G+GS+ KV E K T ++YA+K++KK+ I DD+E EK + A+ HPFL LHS FQT RL +V+E+VNGGDLM+ +QR + E A+FYAAE+ AL FLHR +IYRDLKLDN+L+D +GH +L D+GMCKEGI D +TFCGTP+YIAPEIL+ YG SVDWW+LGVLM+EM+AG QP P E + ED LF IL + P +S +A +ILK + K+ +RL C S +D + H FFR ++WD L ++++PPF+P++ RD NFD FT E + TP D + + I+Q EF GF +INP
Sbjct: 249 HRFSVHSYKRPTFCDHCGSMLYGLINQGLQCST--------CKLNVHKRCQRN------------------VANNCGINAKQMAAE---------LAQLGLTGD-KMSIRS---KKKPSIMTDTSTDISGSSNSENSGYLQQISEDDSGTTSSRSASKVPGGTLSIHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAG-----QP----PFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFFREIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAVVRAINQDEFRGFSFINP 703 HSP 2 Score: 65.0846 bits (157), Expect = 1.420e-10 Identity = 29/65 (44.62%), Postives = 42/65 (64.62%), Query Frame = 3
Query: 345 RRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
RRGA R +K + + GHKF A + C +CK+ IWG+G+QG +C C +++HKRC + V KC
Sbjct: 157 RRGAMR-RKIHEVTGHKFMALFLRQPTFCAHCKEFIWGIGKQGYQCQICTVVVHKRCHEDVVWKC 220
BLAST of Protein kinase C vs. Ensembl Celegans
Match: pkc-1 (Protein kinase C-like 1B [Source:UniProtKB/Swiss-Prot;Acc:P34885]) HSP 1 Score: 352.058 bits (902), Expect = 1.927e-110 Identity = 198/503 (39.36%), Postives = 278/503 (55.27%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRK------GKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDD-FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINP 1877
H+FS + + C +C ++GL QGL+C T C+ V +C + A N GI E +LG D K +R+ + ++ +T++ + S+ S L D G T R G + + DF + V+G+GS+ KV E K T ++YA+K++KK+ I DD+E EK + A+ HPFL LHS FQT RL +V+E+VNGGDLM+ +QR + E A+FYAAE+ AL FLHR +IYRDLKLDN+L+D +GH +L D+GMCKEGI D +TFCGTP+YIAPEIL+ YG SVDWW+LGVLM+EM+AG QP P E + ED LF IL + P +S +A +ILK + K+ +RL C S +D + H FFR ++WD L ++++PPF+P++ RD NFD FT E + TP D + + I+Q EF GF +INP
Sbjct: 305 HRFSVHSYKRPTFCDHCGSMLYGLINQGLQCST--------CKLNVHKRCQRN------------------VANNCGINAKQMAAE---------LAQLGLTGD-KMSIRS---KKKPSIMTDTSTDISGSSNSENSGYLQQISEDDSGTTSSRSASKVPGGTLSIHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAG-----QP----PFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFFREIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAVVRAINQDEFRGFSFINP 759 HSP 2 Score: 64.6994 bits (156), Expect = 1.640e-10 Identity = 29/65 (44.62%), Postives = 42/65 (64.62%), Query Frame = 3
Query: 345 RRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
RRGA R +K + + GHKF A + C +CK+ IWG+G+QG +C C +++HKRC + V KC
Sbjct: 213 RRGAMR-RKIHEVTGHKFMALFLRQPTFCAHCKEFIWGIGKQGYQCQICTVVVHKRCHEDVVWKC 276
BLAST of Protein kinase C vs. Ensembl Celegans
Match: pkc-2 (Protein kinase C-like 2 [Source:UniProtKB/Swiss-Prot;Acc:P90980]) HSP 1 Score: 339.347 bits (869), Expect = 1.567e-106 Identity = 172/341 (50.44%), Postives = 224/341 (65.69%), Query Frame = 3
Query: 861 IGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACK--PSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINP 1877
I DFN L V+G+GS+ KV E K TK+++A+KV+KK+ I DD+E TEK V FLV LHSCFQT RL +V+EFVNGGDLMY +Q+ + E A FYAAEIA+ L FLH + IIYRDLKLDNV+++ DGH+K+TD+GMCKE I GD TFCGTP+YIAPEI+ + YG SVDWW+ GVL+FEMLAG QP P + ED LF I + P+S+S +A S+ K LL K+P++RL C S D + H FFR ++W + ++IQPPF+P+L D +NFD FT E TP D+ + +DQ+EFEGF ++NP
Sbjct: 343 IKASDFNFLTVLGKGSFGKVLLGEQKTTKELFAIKVLKKDVIIQDDDVECTMTEKRVLALPEKPSFLVALHSCFQTMDRLYFVMEFVNGGDLMYQIQQVGKFKEPVAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLERDGHIKITDFGMCKENIFGDATTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLFEMLAG-----QP----PFDGEDEDELFTAITEHNVSYPKSLSKEAVSLCKALLIKNPSKRLGCTGDDESASRDIKEHPFFRRIDWFKIETRQIQPPFKPKLKSADDTSNFDSEFTHEVPKLTPIDRLFLMNLDQTEFEGFSFVNP 674 HSP 2 Score: 70.0922 bits (170), Expect = 3.270e-12 Identity = 33/84 (39.29%), Postives = 47/84 (55.95%), Query Frame = 3
Query: 345 RRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC-----GEDFNLPNYQSQIK 581
RRGA R K + + HKF A+ F + C +CKD +WG+ +QG +C C L++HKRC + V C G D + P Q + K
Sbjct: 24 RRGALRQKNVHEIKSHKFIARFFKQPTFCSHCKDFLWGITKQGFQCQVCTLVVHKRCHEFVNFACPGADKGVDTDDPRQQHKWK 107
BLAST of Protein kinase C vs. Ensembl Fly
Match: aPKC (gene:FBgn0261854 transcript:FBtr0303432) HSP 1 Score: 494.967 bits (1273), Expect = 8.005e-169 Identity = 232/349 (66.48%), Postives = 276/349 (79.08%), Query Frame = 3
Query: 858 KIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
+ L DF L+ V+GRGSYAKV VE + T++IYAMKVIKK +TD +DI+WVQTEKHVFE ASNHPFLVGLHSCFQTPSRL +VIEFV GGDLMYHMQR+ R+PEEHA+FYAAEI+LALNFLH + IIYRDLKLDNVL+D++GH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVL++EMLAG SP+ G P++NTEDYLF +IL K IRIPRS+S +A+S+LKG LNK+P RL C S F D +H FF+ ++W+ L K++ PPF+P L DRDL NF P FT E V TPDD I IDQSEFEGFEY+NPLL++ E+ V
Sbjct: 176 QYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV 524 HSP 2 Score: 128.257 bits (321), Expect = 7.313e-31 Identity = 55/106 (51.89%), Postives = 76/106 (71.70%), Query Frame = 3
Query: 231 EAIRLYETNKDAEIM---MHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
EA ++Y T + A M +FP++P +PG+ C GED +YRRGA+RW+K Y + GH F AKRFN+ A C YC+DRIWGLG+QG +C C+LL+HK+C +LV+ C
Sbjct: 9 EAAQIYST-QTATFMSGGASLFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 113
BLAST of Protein kinase C vs. Ensembl Fly
Match: aPKC (gene:FBgn0261854 transcript:FBtr0303433) HSP 1 Score: 493.812 bits (1270), Expect = 1.297e-168 Identity = 232/347 (66.86%), Postives = 275/347 (79.25%), Query Frame = 3
Query: 864 GLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
L DF L+ V+GRGSYAKV VE + T++IYAMKVIKK +TD +DI+WVQTEKHVFE ASNHPFLVGLHSCFQTPSRL +VIEFV GGDLMYHMQR+ R+PEEHA+FYAAEI+LALNFLH + IIYRDLKLDNVL+D++GH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVL++EMLAG SP+ G P++NTEDYLF +IL K IRIPRS+S +A+S+LKG LNK+P RL C S F D +H FF+ ++W+ L K++ PPF+P L DRDL NF P FT E V TPDD I IDQSEFEGFEY+NPLL++ E+ V
Sbjct: 157 SLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV 503 HSP 2 Score: 126.331 bits (316), Expect = 2.566e-30 Identity = 49/86 (56.98%), Postives = 67/86 (77.91%), Query Frame = 3
Query: 282 VFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
+FP++P +PG+ C GED +YRRGA+RW+K Y + GH F AKRFN+ A C YC+DRIWGLG+QG +C C+LL+HK+C +LV+ C
Sbjct: 7 LFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 92
BLAST of Protein kinase C vs. Ensembl Fly
Match: aPKC (gene:FBgn0261854 transcript:FBtr0329888) HSP 1 Score: 494.197 bits (1271), Expect = 1.627e-168 Identity = 232/347 (66.86%), Postives = 275/347 (79.25%), Query Frame = 3
Query: 864 GLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
L DF L+ V+GRGSYAKV VE + T++IYAMKVIKK +TD +DI+WVQTEKHVFE ASNHPFLVGLHSCFQTPSRL +VIEFV GGDLMYHMQR+ R+PEEHA+FYAAEI+LALNFLH + IIYRDLKLDNVL+D++GH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVL++EMLAG SP+ G P++NTEDYLF +IL K IRIPRS+S +A+S+LKG LNK+P RL C S F D +H FF+ ++W+ L K++ PPF+P L DRDL NF P FT E V TPDD I IDQSEFEGFEY+NPLL++ E+ V
Sbjct: 173 SLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV 519 HSP 2 Score: 127.102 bits (318), Expect = 1.299e-30 Identity = 49/86 (56.98%), Postives = 67/86 (77.91%), Query Frame = 3
Query: 282 VFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
+FP++P +PG+ C GED +YRRGA+RW+K Y + GH F AKRFN+ A C YC+DRIWGLG+QG +C C+LL+HK+C +LV+ C
Sbjct: 23 IFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 108
BLAST of Protein kinase C vs. Ensembl Fly
Match: aPKC (gene:FBgn0261854 transcript:FBtr0329890) HSP 1 Score: 495.352 bits (1274), Expect = 1.379e-167 Identity = 232/349 (66.48%), Postives = 276/349 (79.08%), Query Frame = 3
Query: 858 KIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
+ L DF L+ V+GRGSYAKV VE + T++IYAMKVIKK +TD +DI+WVQTEKHVFE ASNHPFLVGLHSCFQTPSRL +VIEFV GGDLMYHMQR+ R+PEEHA+FYAAEI+LALNFLH + IIYRDLKLDNVL+D++GH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVL++EMLAG SP+ G P++NTEDYLF +IL K IRIPRS+S +A+S+LKG LNK+P RL C S F D +H FF+ ++W+ L K++ PPF+P L DRDL NF P FT E V TPDD I IDQSEFEGFEY+NPLL++ E+ V
Sbjct: 155 QYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV 503 HSP 2 Score: 127.102 bits (318), Expect = 3.147e-30 Identity = 49/86 (56.98%), Postives = 67/86 (77.91%), Query Frame = 3
Query: 282 VFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
+FP++P +PG+ C GED +YRRGA+RW+K Y + GH F AKRFN+ A C YC+DRIWGLG+QG +C C+LL+HK+C +LV+ C
Sbjct: 7 LFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 92
BLAST of Protein kinase C vs. Ensembl Fly
Match: aPKC (gene:FBgn0261854 transcript:FBtr0303434) HSP 1 Score: 494.582 bits (1272), Expect = 1.933e-167 Identity = 232/347 (66.86%), Postives = 275/347 (79.25%), Query Frame = 3
Query: 864 GLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
L DF L+ V+GRGSYAKV VE + T++IYAMKVIKK +TD +DI+WVQTEKHVFE ASNHPFLVGLHSCFQTPSRL +VIEFV GGDLMYHMQR+ R+PEEHA+FYAAEI+LALNFLH + IIYRDLKLDNVL+D++GH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVL++EMLAG SP+ G P++NTEDYLF +IL K IRIPRS+S +A+S+LKG LNK+P RL C S F D +H FF+ ++W+ L K++ PPF+P L DRDL NF P FT E V TPDD I IDQSEFEGFEY+NPLL++ E+ V
Sbjct: 260 SLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV 606 HSP 2 Score: 206.453 bits (524), Expect = 1.294e-57 Identity = 91/165 (55.15%), Postives = 125/165 (75.76%), Query Frame = 3
Query: 45 IKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
I +K Y + IT IN +++Y++L YEI IC P FT+KW+D+E DPCTI+T+MELDEAIRLYE N D+++++HVFP++P +PG+ C GED +YRRGA+RW+K Y + GH F AKRFN+ A C YC+DRIWGLG+QG +C C+LL+HK+C +LV+ C
Sbjct: 31 ITVKTAYNGQIIITTINKNISYEELCYEIRNICRFPLDQPFTIKWVDEENDPCTISTKMELDEAIRLYEMNFDSQLVIHVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 195
BLAST of Protein kinase C vs. Ensembl Zebrafish
Match: prkci (protein kinase C, iota [Source:NCBI gene;Acc:117507]) HSP 1 Score: 680.248 bits (1754), Expect = 0.000e+0 Identity = 328/620 (52.90%), Postives = 426/620 (68.71%), Query Frame = 3
Query: 45 IKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
+++K Y + IT S++Y+ L E+ +C + + FTMKWID+EGDPCT+++Q+EL+EA+RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y+ GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG Q+ + I R +PG ++ ++P + + I H+ + AV R +G +GL DF+LL V+GRGSYAKV V K T++IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LKG LNK+ +RL C P + F D H FFR ++WD + K++ PPF+P ++ + L NFD FT+EP+ TPDD + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 19 VRVKAYYRGDIMITHFEPSISYEGLCNEVRDMCSMDNDQLFTMKWIDEEGDPCTVSSQLELEEALRLYELNKDSELIIHVFPCVPEKPGMPCPGEDKSIYRRGARRWRKLYYATGHAFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTVECGR---------QVIQDPMIGRI-------DPG---STHPEHPDQVLGKKNSTESINHE---GEEHEAVGSRE----------------------------SGKAVSSLGLIDFDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKGFLNKESKERLGCHPQTGFADIMAHPFFRNVDWDLMEQKQVVPPFKPNISGEFGLDNFDAQFTNEPIQLTPDDDDAVKKIDQSEFEGFEYINPLLMSAEECV 588
BLAST of Protein kinase C vs. Ensembl Zebrafish
Match: prkcz (protein kinase C, zeta [Source:ZFIN;Acc:ZDB-GENE-070511-1]) HSP 1 Score: 667.152 bits (1720), Expect = 0.000e+0 Identity = 329/626 (52.56%), Postives = 431/626 (68.85%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFN--LPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGK-IGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S +K+K Y + I+ ++ ++TY ++ E+ ++C + + T+KWIDDEGDPCTI++QMEL+EA R+Y N+ + +++HVFPS+P PGMPC GED +YRRGA+RW+K Y + GH F AKRFN+ A C +C +RIWGLG+QG +C C+LL+HKRC +LV C + +P+ + + + + + +E P E PV +V+ + D + D + V +G G + + +GLGDF+L+ V+GRGSYAKV V K ++IYAMKV+KKE + D +DI+WVQTEKHVFE AS +PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH + IIYRDLKLDNVL+D DGH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTE+YLF +IL KPIRIPRS+S KA+S+LKG LNKDP +RL C+ + F D ++H FFR ++WD L K++ PPF+P++T D L NFD FT+EPV TPDD+ I +IDQSEFEGFEYINPLLL+TEE V
Sbjct: 13 SEYVKIKAHYGGDMLISDLDLALTYTEVCKEVREMCGVRKETPITLKWIDDEGDPCTISSQMELEEAFRIYSRNRHSGLLLHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGHCSERIWGLGRQGYKCINCKLLVHKRCHKLVPLTCQRHMDPVMPSQEPLVDDDKSGEE------VELPPEDPEDTDAIPVPFLAHNRKVEKAEDD--SEDLKAVV-----------------------------DGIEGIQISQCLGLGDFDLIRVIGRGSYAKVLLVRLKKNEQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPFLVGLHSCFQTESRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQVQTGFTDIKSHTFFRSIDWDQLEQKQVTPPFKPQITDDYGLENFDTQFTNEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSTEETV 599
BLAST of Protein kinase C vs. Ensembl Zebrafish
Match: prkcz (protein kinase C, zeta [Source:ZFIN;Acc:ZDB-GENE-070511-1]) HSP 1 Score: 667.152 bits (1720), Expect = 0.000e+0 Identity = 329/626 (52.56%), Postives = 431/626 (68.85%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFN--LPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGK-IGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S +K+K Y + I+ ++ ++TY ++ E+ ++C + + T+KWIDDEGDPCTI++QMEL+EA R+Y N+ + +++HVFPS+P PGMPC GED +YRRGA+RW+K Y + GH F AKRFN+ A C +C +RIWGLG+QG +C C+LL+HKRC +LV C + +P+ + + + + + +E P E PV +V+ + D + D + V +G G + + +GLGDF+L+ V+GRGSYAKV V K ++IYAMKV+KKE + D +DI+WVQTEKHVFE AS +PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH + IIYRDLKLDNVL+D DGH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTE+YLF +IL KPIRIPRS+S KA+S+LKG LNKDP +RL C+ + F D ++H FFR ++WD L K++ PPF+P++T D L NFD FT+EPV TPDD+ I +IDQSEFEGFEYINPLLL+TEE V
Sbjct: 13 SEYVKIKAHYGGDMLISDLDLALTYTEVCKEVREMCGVRKETPITLKWIDDEGDPCTISSQMELEEAFRIYSRNRHSGLLLHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGHCSERIWGLGRQGYKCINCKLLVHKRCHKLVPLTCQRHMDPVMPSQEPLVDDDKSGEE------VELPPEDPEDTDAIPVPFLAHNRKVEKAEDD--SEDLKAVV-----------------------------DGIEGIQISQCLGLGDFDLIRVIGRGSYAKVLLVRLKKNEQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPFLVGLHSCFQTESRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQVQTGFTDIKSHTFFRSIDWDQLEQKQVTPPFKPQITDDYGLENFDTQFTNEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSTEETV 599
BLAST of Protein kinase C vs. Ensembl Zebrafish
Match: prkcea (protein kinase C, epsilon a [Source:ZFIN;Acc:ZDB-GENE-030131-8191]) HSP 1 Score: 356.681 bits (914), Expect = 3.130e-112 Identity = 198/525 (37.71%), Postives = 287/525 (54.67%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDF------------------NLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLR-ASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEG-GTGDRKG----KIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDD-FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLT 1889
H FS + C +C +WGL +QGL+C C++ +H+RC+ V CG D N + ++ Q++ +S P D EL +++ I+ L +H+ + + + + EG GD K ++ L DF+ + V+G+GS+ KV E K T ++YA+KV+KK+ I DD++ TEK + A HP+L L CFQT RL +V+E+VNGGDLM+ +QR + E ++FYAAE+ AL FLH+ +IYRDLKLDN+L+D +GH KL D+GMCKEGI + TTFCGTP+YIAPEIL+ YG SVDWW+LGVLM+EM+AG QP P E + ED LF IL + P +S +A SILK + K+P++RL C + ++ + H FFR ++W L ++I+PPF+P + RD+ NFD FT E + TP D + I +I+Q EF+GF Y L+
Sbjct: 247 HMFSIHNYKVPTFCDHCGSLLWGLMRQGLQCKACKMNVHRRCESNVAPSCGVDARKIAKVLSDLGVTPDKISNSTQRRKKLTPGQDPQQSTTEAPSSEESDRCKSAPTSPCDQ-AELAELESIRKALSFGQEHKSSSSSSCSGVQS-----------------TEIEGRENGDLKTVQTKRMSLTDFSFIKVLGKGSFGKVMLAELKGTDEVYAVKVLKKDVILQDDDVDCTLTEKRILALARKHPYLTQLFCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAG-----QP----PFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPSKRLGCVVTQGLEEAIKVHPFFREIDWVQLEQRRIKPPFKPRIKTKRDVNNFDQDFTREDPVLTPVDDAIIKQINQEEFKGFSYFGEEALS 744 HSP 2 Score: 62.3882 bits (150), Expect = 1.348e-9 Identity = 28/67 (41.79%), Postives = 42/67 (62.69%), Query Frame = 3
Query: 345 RRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWG-LGQQGLRCGTCRLLLHKRCQQLVKHKCG 542
R+GA R ++ + + GHKF A + C +C+D IWG LG+QG +C C ++HKRC +L+ KC
Sbjct: 159 RQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELIITKCA 224
BLAST of Protein kinase C vs. Ensembl Zebrafish
Match: prkceb (protein kinase C, epsilon b [Source:ZFIN;Acc:ZDB-GENE-081028-47]) HSP 1 Score: 355.525 bits (911), Expect = 6.478e-112 Identity = 198/525 (37.71%), Postives = 289/525 (55.05%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQ--------------VKDIKHDLRAS--DHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIG--------LGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDD-FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLT 1889
HKF + C +C +WGL +QGL+C C++ +HKRC+ V CG D +++ S++ + +G ++ + +P+ L + +KD+++ +A DHR +S V E G G++ L DF+ + V+G+GS+ KV E + T +++A+KV+KK+ I DD++ TEK + A HP+L L+ CFQT RL +V+E+VNGGDLM+ +QR + E ++FYAAE+ AL FLH +IYRDLKLDN+L+D +GH KL D+GMCKEGI I TTFCGTP+YIAPEIL+ YG SVDWW+LGVLM+EM+AG QP P E + ED LF IL + P +S +A SILK + K P++RL C S +D + H FF+ ++W L +K++PPF+P + RD+ NFD FT E + TP + + I +I+Q EF+GF Y L+
Sbjct: 245 HKFRIHNYKVLTFCDHCGSLLWGLLRQGLQCKVCKMNVHKRCEINVAPNCGVD---ARGIAKVLSDLGVTPDKLSGSVQRRKKISQGPDPHPLPISPLLEEDRCKSAPTSPCDQDIKDLENIRKALSFDHR-------------------SEEMKQASEGVSEETGEARENGEVKTVQAKRMMLEDFSFIKVLGKGSFGKVMLAELRGTDEVFAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHHNGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILDGITTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAG-----QP----PFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKSPSKRLGCVVSQGLEDAIKVHPFFKDIDWVLLEQRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTPVEDAIIKQINQEEFKGFSYFGEETLS 738 HSP 2 Score: 65.4698 bits (158), Expect = 1.738e-10 Identity = 53/171 (30.99%), Postives = 84/171 (49.12%), Query Frame = 3
Query: 75 ATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWI--DDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFP----SLPTSPGMPCQGEDLKVYR--------RGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWG-LGQQGLRCGTCRLLLHKRCQQLVKHKCG 542
+T + N+ +D+L E+H + ++S F I DD CTI + L + +E D E VF S +S C+ E+ +V+R +GA R ++ + + GHKF A + C +C+D IWG LG+QG +C C ++HKRC +L+ KC
Sbjct: 55 STKQKTNSPAWHDELVTEVHDGRKI-ELSVFHDAPIGYDDFVANCTIQFEELLHNGSKHFEDWIDLEPEGKVFVIIDLSGSSSEAGGCENEE-RVFRERMRPRKRQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELIITKCA 222
BLAST of Protein kinase C vs. Ensembl Xenopus
Match: prkcz (protein kinase C zeta [Source:NCBI gene;Acc:100101769]) HSP 1 Score: 667.537 bits (1721), Expect = 0.000e+0 Identity = 334/629 (53.10%), Postives = 419/629 (66.61%), Query Frame = 3
Query: 24 KMHESALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGE--DFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
KM S IK+K Y + IT++ + + Y+QL E+ ++C L T+KWIDDEGDPCTI++QMEL+EA RLY K+ + +HVFPS+P PGMPC GED +YRRGA+RW+K Y + GH F AKRFN+ A C C +RIWGLG+QG +C C+LL+HKRC LV C + D +P + Q+ +D P + +E+ + KH+ R P +D G +G +GL DF L+ V+GRGSYAKV V K + YAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQTPSRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+ + F D ++H FFR ++WD L K++ PPF+P++T D L NFD FT EPV TPDD+ I +IDQSEFEGFEYINPLL+++EE V
Sbjct: 8 KMDLSKDIKIKAHYKGDILITRLGSYLNYEQLCDEVREMCYLNQRQPITLKWIDDEGDPCTISSQMELEEAFRLYSIYKEEGLSIHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGQCSERIWGLGRQGYKCINCKLLVHKRCHILVPLTCKKHMDLVMPFQEPQVDDK-------------------SDEVDPPSEEIDEISIIAPRKHENRKDGSE------------------------DLKPVIDGMDGIKISQG-LGLQDFELIRVIGRGSYAKVLLVRLKKNDQTYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTPSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCQLQTGFSDIKSHTFFRSIDWDMLEKKQVVPPFKPQITDDYGLENFDTQFTSEPVQLTPDDEETIKRIDQSEFEGFEYINPLLISSEETV 590
BLAST of Protein kinase C vs. Ensembl Xenopus
Match: zfhx4 (zinc finger homeobox 4 [Source:Xenbase;Acc:XB-GENE-957673]) HSP 1 Score: 660.603 bits (1703), Expect = 0.000e+0 Identity = 324/626 (51.76%), Postives = 418/626 (66.77%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYV---ESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S +++K + + IT S+T+D L E+ +C + FTMKWID+EGDPCT+++Q+EL+EA RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y GH F AKRFN+ A C C DRIWGLG+QG +C C+L LV KC + ++ + I + ++ PG + E + Y + L QV + K + + + +G +GL DF+L+ V+GRGSYAKV V K T++IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTED+LF +IL K IRIPRS+S KA+S+LK LNKDP RL C P + F D Q H FFR ++WD + K++ PPF+P ++ + L NFD FT+EPV TPDD+ + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 16 SHQVRVKAYFKGDIMITHFEPSITFDGLCNEVRDMCSFENDQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCIPERPGMPCAGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL--------LVHKKCHKLVSIECGRHTIAEPVI--------PMDPPGMHSDHSEPELPYRPRSQDNLDQVGEEKEAMNSRE-------------------------------------SGKTPSSLGLQDFDLMRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDFLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKDRLGCHPQTGFADIQGHQFFRNVDWDLMEQKQVVPPFKPNISGEFGLDNFDAQFTNEPVQLTPDDEDVVRKIDQSEFEGFEYINPLLMSAEECV 588
BLAST of Protein kinase C vs. Ensembl Xenopus
Match: prkcz (protein kinase C zeta [Source:NCBI gene;Acc:100101769]) HSP 1 Score: 659.448 bits (1700), Expect = 0.000e+0 Identity = 333/628 (53.03%), Postives = 418/628 (66.56%), Query Frame = 3
Query: 27 MHESALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGE--DFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
M S IK+K Y + IT++ + + Y+QL E+ ++C L T+KWIDDEGDPCTI++QMEL+EA RLY K+ + +HVFPS+P PGMPC GED +YRRGA+RW+K Y + GH F AKRFN+ A C C +RIWGLG+QG +C C+LL+HKRC LV C + D +P + Q+ +D P EE+ + + I ++S P +D G +G +GL DF L+ V+GRGSYAKV V K + YAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQTPSRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+ + F D ++H FFR ++WD L K++ PPF+P++T D L NFD FT EPV TPDD+ I +IDQSEFEGFEYINPLL+++EE V
Sbjct: 1 MDLSKDIKIKAHYKGDILITRLGSYLNYEQLCDEVREMCYLNQRQPITLKWIDDEGDPCTISSQMELEEAFRLYSIYKEEGLSIHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGQCSERIWGLGRQGYKCINCKLLVHKRCHILVPLTCKKHMDLVMPFQEPQVDDK-------------------SDEVDPPS---EEIDESRLIACHTKSS--------------------TCNKTYRDLKPVIDGMDGIKISQG-LGLQDFELIRVIGRGSYAKVLLVRLKKNDQTYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTPSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCQLQTGFSDIKSHTFFRSIDWDMLEKKQVVPPFKPQITDDYGLENFDTQFTSEPVQLTPDDEETIKRIDQSEFEGFEYINPLLISSEETV 583
BLAST of Protein kinase C vs. Ensembl Xenopus
Match: prkcz (protein kinase C zeta [Source:NCBI gene;Acc:100101769]) HSP 1 Score: 652.899 bits (1683), Expect = 0.000e+0 Identity = 327/610 (53.61%), Postives = 410/610 (67.21%), Query Frame = 3
Query: 81 ITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGE--DFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
IT++ + + Y+QL E+ ++C L T+KWIDDEGDPCTI++QMEL+EA RLY K+ + +HVFPS+P PGMPC GED +YRRGA+RW+K Y + GH F AKRFN+ A C C +RIWGLG+QG +C C+LL+HKRC LV C + D +P + Q+ +D P EE+ + + I ++S P +D G +G +GL DF L+ V+GRGSYAKV V K + YAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQTPSRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+ + F D ++H FFR ++WD L K++ PPF+P++T D L NFD FT EPV TPDD+ I +IDQSEFEGFEYINPLL+++EE V
Sbjct: 29 ITRLGSYLNYEQLCDEVREMCYLNQRQPITLKWIDDEGDPCTISSQMELEEAFRLYSIYKEEGLSIHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGQCSERIWGLGRQGYKCINCKLLVHKRCHILVPLTCKKHMDLVMPFQEPQVDDK-------------------SDEVDPPS---EEIDESRLIACHTKSS--------------------TCNKTYRDLKPVIDGMDGIKISQG-LGLQDFELIRVIGRGSYAKVLLVRLKKNDQTYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTPSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCQLQTGFSDIKSHTFFRSIDWDMLEKKQVVPPFKPQITDDYGLENFDTQFTSEPVQLTPDDEETIKRIDQSEFEGFEYINPLLISSEETV 593
BLAST of Protein kinase C vs. Ensembl Xenopus
Match: prkcz (protein kinase C zeta [Source:NCBI gene;Acc:100101769]) HSP 1 Score: 652.899 bits (1683), Expect = 0.000e+0 Identity = 327/610 (53.61%), Postives = 410/610 (67.21%), Query Frame = 3
Query: 81 ITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGE--DFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
IT++ + + Y+QL E+ ++C L T+KWIDDEGDPCTI++QMEL+EA RLY K+ + +HVFPS+P PGMPC GED +YRRGA+RW+K Y + GH F AKRFN+ A C C +RIWGLG+QG +C C+LL+HKRC LV C + D +P + Q+ +D P EE+ + + I ++S P +D G +G +GL DF L+ V+GRGSYAKV V K + YAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQTPSRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+ + F D ++H FFR ++WD L K++ PPF+P++T D L NFD FT EPV TPDD+ I +IDQSEFEGFEYINPLL+++EE V
Sbjct: 24 ITRLGSYLNYEQLCDEVREMCYLNQRQPITLKWIDDEGDPCTISSQMELEEAFRLYSIYKEEGLSIHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGQCSERIWGLGRQGYKCINCKLLVHKRCHILVPLTCKKHMDLVMPFQEPQVDDK-------------------SDEVDPPS---EEIDESRLIACHTKSS--------------------TCNKTYRDLKPVIDGMDGIKISQG-LGLQDFELIRVIGRGSYAKVLLVRLKKNDQTYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTPSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCQLQTGFSDIKSHTFFRSIDWDMLEKKQVVPPFKPQITDDYGLENFDTQFTSEPVQLTPDDEETIKRIDQSEFEGFEYINPLLISSEETV 588
BLAST of Protein kinase C vs. Ensembl Mouse
Match: Prkci (protein kinase C, iota [Source:MGI Symbol;Acc:MGI:99260]) HSP 1 Score: 682.174 bits (1759), Expect = 0.000e+0 Identity = 330/623 (52.97%), Postives = 418/623 (67.09%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S +++K Y + IT S++++ L E+ +C + FTMKWID+EGDPCT+++Q+EL+EA RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG P + M T ++ I Y E L QV + K + + +G +GL DF+LL V+GRGSYAKV V K T +IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LK LNKDP +RL C P + F D Q H FFR ++WD + K++ PPF+P ++ + L NFD FT+EPV TPDD + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 23 SHQVRVKAYYRGDIMITHFEPSISFEGLCSEVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPPEPMMPMDQTMHPDHT-------------QTVIPYNPSSHESLDQVGEEKEAMNTRE-------------------------------------SGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 595
BLAST of Protein kinase C vs. Ensembl Mouse
Match: Prkcz (protein kinase C, zeta [Source:MGI Symbol;Acc:MGI:97602]) HSP 1 Score: 657.136 bits (1694), Expect = 0.000e+0 Identity = 331/622 (53.22%), Postives = 416/622 (66.88%), Query Frame = 3
Query: 45 IKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGE--DFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
++LK Y + IT ++A T+ L E+ +C L T+KW+D EGDPCT+++QMEL+EA RL +D +++HVFPS+P PGMPC GED +YRRGA+RW+K Y GH F AKRFN+ A C C +RIWGL +QG RC C+LL+HKRC LV C D +P+ + + +N G++ P + I Y + + +KD DL+ P +D G +G +GL DF+L+ V+GRGSYAKV V K +IYAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+P + F D ++HAFFR ++WD L K+ PPF+P++T D L NFD FT EPV TPDD+ I +IDQSEFEGFEYINPLLL+ EE+V
Sbjct: 16 VRLKAHYGGDILITSVDAMTTFKDLCEEVRDMCGLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLVCQGRDEVLIIHVFPSIPEQPGMPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRGAYCGQCSERIWGLSRQGYRCINCKLLVHKRCHVLVPLTCRRHMDSVMPSQEPPVDD--------KNDGVDLPSEETD-GIAY-ISSSRKHDNIKDDSEDLK--------------------------------PVIDGVDGIKISQG-LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSAEESV 592
BLAST of Protein kinase C vs. Ensembl Mouse
Match: Prkcz (protein kinase C, zeta [Source:MGI Symbol;Acc:MGI:97602]) HSP 1 Score: 492.656 bits (1267), Expect = 2.349e-169 Identity = 237/363 (65.29%), Postives = 283/363 (77.96%), Query Frame = 3
Query: 816 PPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
P +D G +G +GL DF+L+ V+GRGSYAKV V K +IYAMKV+KKE + D +DI+WVQTEKHVFE AS++PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH R IIYRDLKLDNVL+D DGH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTEDYLF +IL KPIRIPR +S KAS +LKG LNKDP +RL C+P + F D ++HAFFR ++WD L K+ PPF+P++T D L NFD FT EPV TPDD+ I +IDQSEFEGFEYINPLLL+ EE+V
Sbjct: 50 PVIDGVDGIKISQG-LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSAEESV 409
BLAST of Protein kinase C vs. Ensembl Mouse
Match: Prkch (protein kinase C, eta [Source:MGI Symbol;Acc:MGI:97600]) HSP 1 Score: 362.073 bits (928), Expect = 6.500e-115 Identity = 200/534 (37.45%), Postives = 291/534 (54.49%), Query Frame = 3
Query: 375 YHLYGHKFSAKRFNKYAECFYCKDRIWGL-GQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGF-EELGQV--KDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXX------------------PPVDTEGGTGDRKG---------KIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLL 1883
+ + GHKF A + C +C++ IWG+ G+QG +C C ++HKRC L+ C N+ +++ + +A QR GI P + N Y V F + G + ++ L+ ++ V +R + L+ + + +G G ++G + G+ +F + V+G+GS+ KV K T ++YA+KV+KK+ I DD+E TEK + A NHPFL L CFQTP RL +V+EFVNGGDLM+H+Q+ R E A+FYAAEI AL FLH + IIYRDLKLDNVL+D++GH KL D+GMCKEGI + TFCGTP+YIAPEIL+ YG +VDWW++GVL++EML G +P+ E ED LF IL + P + A+ ILK + K+PT RL + H FF+ ++W L ++++PPFRP + D++NFDP F E + TP D+ + I+Q EF F Y++P L
Sbjct: 167 HQVNGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNI----NKVDAKIAEQRF----GINIPHKFNVHN--YKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLISRSTLRRQGKEGSKEGNGIGVNSSSRFGIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF---------EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFFKEIDWAQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
BLAST of Protein kinase C vs. Ensembl Mouse
Match: Prkce (protein kinase C, epsilon [Source:MGI Symbol;Acc:MGI:97599]) HSP 1 Score: 363.229 bits (931), Expect = 7.464e-115 Identity = 209/523 (39.96%), Postives = 295/523 (56.41%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDF--------NLPNYQSQIKSNMAIQRTAENGGIENP----------GYYVESNIDYPVDGFEELGQV-----KDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDD-FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLL 1886
HKF + C +C +WGL +QGL+C C++ +H+RC+ V CG D +L +I +N +R G E+P +S P D +EL ++ K + D R +HR + A L+SP + E G K ++GL +FN + V+G+GS+ KV E K ++YA+KV+KK+ I DD++ TEK + A HP+L L+ CFQT RL +V+E+VNGGDLM+ +QR + E ++FYAAE+ AL FLH+ +IYRDLKLDN+L+D +GH KL D+GMCKEGI + TTFCGTP+YIAPEIL+ YG SVDWW+LGVLM+EM+AG QP P E + ED LF IL + P +S +A SILK + K+P +RL C + N +D + H FF+ ++W L KKI+PPF+P + RD+ NFD FT E + T D++ I +I+Q EF+GF Y L+
Sbjct: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKI-TNSGQRRKKLAAGAESPQPASGNSPSEDDRSKSAPTSPCD--QELKELENNIRKALSFDNRGEEHRASSAT----------------DGQLASPGENGEVRPGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAG-----QP----PFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAIIKQINQEEFKGFSYFGEDLM 736 HSP 2 Score: 64.3142 bits (155), Expect = 3.824e-10 Identity = 41/131 (31.30%), Postives = 66/131 (50.38%), Query Frame = 3
Query: 183 DDEGDPCTITTQMELDEAIRLYE--TNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYR--------RGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWG-LGQQGLRCGTCRLLLHKRCQQLVKHKCG 542
DD CTI + L R +E + + E ++V L S G + + +V+R +GA R ++ + + GHKF A + C +C+D IWG +G+QG +C C ++HKRC +L+ KC
Sbjct: 92 DDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCA 221
BLAST of Protein kinase C vs. UniProt/SwissProt
Match: sp|P41743|KPCI_HUMAN (Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2) HSP 1 Score: 684.485 bits (1765), Expect = 0.000e+0 Identity = 332/628 (52.87%), Postives = 424/628 (67.52%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCG-----EDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S +++K Y + IT S++++ L E+ +C + FTMKWID+EGDPCT+++Q+EL+EA RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG ++ +P QS + S+ A ++ I Y E L QV + K + + +G +GL DF+LL V+GRGSYAKV V K T +IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LK LNKDP +RL C P + F D Q H FFR ++WD + K++ PPF+P ++ + L NFD FT+EPV TPDD + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 23 SHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHA-----------------QTVIPYNPSSHESLDQVGEEKEAMNTRE-------------------------------------SGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
BLAST of Protein kinase C vs. UniProt/SwissProt
Match: sp|Q5R4K9|KPCI_PONAB (Protein kinase C iota type OS=Pongo abelii OX=9601 GN=PRKCI PE=2 SV=2) HSP 1 Score: 683.33 bits (1762), Expect = 0.000e+0 Identity = 332/628 (52.87%), Postives = 423/628 (67.36%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGE-----DFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S +++K Y + IT S++++ L E+ +C + FTMKWID+EGDPCT+++Q+EL+EA RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG + +P QS + S+ A ++ I Y E L QV + K + + +G +GL DF+LL V+GRGSYAKV V K T +IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LK LNKDP +RL C P + F D Q H FFR ++WD + K++ PPF+P ++ + L NFD FT+EPV TPDD + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 23 SHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPPEPMMPMDQSSMHSDHA-----------------QTVIPYNPSSHESLDQVGEEKEAMNTRE-------------------------------------SGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
BLAST of Protein kinase C vs. UniProt/SwissProt
Match: sp|Q62074|KPCI_MOUSE (Protein kinase C iota type OS=Mus musculus OX=10090 GN=Prkci PE=1 SV=3) HSP 1 Score: 682.174 bits (1759), Expect = 0.000e+0 Identity = 330/623 (52.97%), Postives = 418/623 (67.09%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S +++K Y + IT S++++ L E+ +C + FTMKWID+EGDPCT+++Q+EL+EA RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG P + M T ++ I Y E L QV + K + + +G +GL DF+LL V+GRGSYAKV V K T +IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LK LNKDP +RL C P + F D Q H FFR ++WD + K++ PPF+P ++ + L NFD FT+EPV TPDD + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 23 SHQVRVKAYYRGDIMITHFEPSISFEGLCSEVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPPEPMMPMDQTMHPDHT-------------QTVIPYNPSSHESLDQVGEEKEAMNTRE-------------------------------------SGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 595
BLAST of Protein kinase C vs. UniProt/SwissProt
Match: sp|F1M7Y5|KPCI_RAT (Protein kinase C iota type OS=Rattus norvegicus OX=10116 GN=Prkci PE=1 SV=1) HSP 1 Score: 681.019 bits (1756), Expect = 0.000e+0 Identity = 330/623 (52.97%), Postives = 425/623 (68.22%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S +++K Y + IT S++++ L E+ +C + FTMKWID+EGDPCT+++Q+EL+EA RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG +LP + M + +++ + + ++ I Y E L QV + K + + +G +GL DF+LL V+GRGSYAKV V K T +IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LK LNKDP +RL C P + F D Q H FFR ++WD + K++ PPF+P ++ + L NFD FT+EPV TPDD + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 23 SHQVRVKAYYRGDIMITHFEPSISFEGLCSEVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGR-HSLPP-----EPMMPMDQSSMHPD------HTQTVIPYNPSSHESLDQVGEEKEAMNTRE-------------------------------------SGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
BLAST of Protein kinase C vs. UniProt/SwissProt
Match: sp|Q90XF2|KPCI_DANRE (Protein kinase C iota type OS=Danio rerio OX=7955 GN=prkci PE=2 SV=2) HSP 1 Score: 680.248 bits (1754), Expect = 0.000e+0 Identity = 328/620 (52.90%), Postives = 426/620 (68.71%), Query Frame = 3
Query: 45 IKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
+++K Y + IT S++Y+ L E+ +C + + FTMKWID+EGDPCT+++Q+EL+EA+RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y+ GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG Q+ + I R +PG ++ ++P + + I H+ + AV R +G +GL DF+LL V+GRGSYAKV V K T++IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LKG LNK+ +RL C P + F D H FFR ++WD + K++ PPF+P ++ + L NFD FT+EP+ TPDD + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 19 VRVKAYYRGDIMITHFEPSISYEGLCNEVRDMCSMDNDQLFTMKWIDEEGDPCTVSSQLELEEALRLYELNKDSELIIHVFPCVPEKPGMPCPGEDKSIYRRGARRWRKLYYATGHAFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTVECGR---------QVIQDPMIGRI-------DPG---STHPEHPDQVLGKKNSTESINHE---GEEHEAVGSRE----------------------------SGKAVSSLGLIDFDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKGFLNKESKERLGCHPQTGFADIMAHPFFRNVDWDLMEQKQVVPPFKPNISGEFGLDNFDAQFTNEPIQLTPDDDDAVKKIDQSEFEGFEYINPLLMSAEECV 588
BLAST of Protein kinase C vs. TrEMBL
Match: A0A504Y6V3 (Protein kinase C OS=Fasciola gigantica OX=46835 GN=FGIG_00574 PE=3 SV=1) HSP 1 Score: 713.375 bits (1840), Expect = 0.000e+0 Identity = 349/655 (53.28%), Postives = 442/655 (67.48%), Query Frame = 3
Query: 45 IKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKK-FYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNI---DYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGG-------------------------------TGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
I +K I+ S A +T + + +R ++ ++C FT+KWID+E DPC +++ +ELDEA+RL NK+ ++ + VF +P+ PG PC GEDL +YRRGAKRWKK +Y L+GHKF+A+RFNK AEC YC RIWGLGQQG +C TCRLLLH+RC+ V+HKCGE +P + + + E N Y+ +N P+ V+ H+ A+ +A A ++ P D E T G++GL DF LL V+GRGSYAKVFQVE+ PT++IYAMKVIKKE I D +DIEWVQTEKHVFECA+NHPFLVGLHSCFQT SRL +VIEFVNGGDLM++MQR LR+ E++A+FY+AEI LALNFLH R IIYRDLKLDNVLMD++GH+KLTDYGMCKEGI D+ +TFCGTPNYIAPEILR E Y SVDWW+LGVLMFEMLAG SPW GQ + ++N+EDYLF +ILT+PIR PRSIS +A++IL+ L K+P +RL C P SNF D NH+FFR ++W L K+I PP+RP +D DLT+FDP FTDEPV+FTPD++ +SKIDQ+EFEGFEY+NPLL+T EE V
Sbjct: 8 IPVKYIHNSIAMVTNLPSQADLKAMRSQVMELCQFSPDCRFTLKWIDEEQDPCVLSSDLELDEAVRLLHLNKECQLTVLVFDGIPSEPGKPCPGEDLSMYRRGAKRWKKKYYLLHGHKFAARRFNKNAECAYCHGRIWGLGQQGFKCITCRLLLHRRCRGCVQHKCGEPLTIPGPLNPVTVGRVTPLSPET---PNEFAYLNNNTGANSRPISYQLSHAGVETPNHNSGATRLEIAYAQQSTFEEERNRPRTGIQNPAFVDRPSDVEHTRKPRCTEISVPRPDVVIPILEERIAEMSVVTTTSSSGQVGLQDFKLLKVIGRGSYAKVFQVEHIPTQRIYAMKVIKKETILDEEDIEWVQTEKHVFECATNHPFLVGLHSCFQTDSRLFFVIEFVNGGDLMFYMQRNLRLAEDYARFYSAEICLALNFLHERGIIYRDLKLDNVLMDSEGHIKLTDYGMCKEGITADVMTSTFCGTPNYIAPEILRGENYNFSVDWWALGVLMFEMLAGRSPWENVGQSVNQDQNSEDYLFQVILTRPIRFPRSISVRATNILRAFLTKNPAERLGCLPDSNFADIMNHSFFRPVDWVALEQKQIAPPYRPTYANDYDLTHFDPTFTDEPVVFTPDNEEVVSKIDQTEFEGFEYVNPLLMTLEEPV 659
BLAST of Protein kinase C vs. TrEMBL
Match: A0A4E0R550 (Protein kinase C OS=Fasciola hepatica OX=6192 GN=D915_008611 PE=3 SV=1) HSP 1 Score: 709.523 bits (1830), Expect = 0.000e+0 Identity = 348/655 (53.13%), Postives = 440/655 (67.18%), Query Frame = 3
Query: 45 IKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKK-FYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDY---PVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGG-------------------------------TGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
I +K I+ S A +T + + ++ ++ ++C FT+KWID+E DPC +++ +EL+EA+RL NK+ ++ + VF +P PG PC GEDL +YRRGAKRWKK +Y L+GHKF+A+RFNK AEC YC RIWGLGQQG +C TCRLLLH+RC+ V+HKCGE +P + + + E N Y+ +N P V+ H+ AS +A A ++ P D E T G++GL DF LL V+GRGSYAKVFQVE+ PT++IYAMKVIKKE I D +DIEWVQTEKHVFECA+NHPFLVGLHSCFQT SRL +VIEFVNGGDLM++MQR LR+ E++A+FY+AEI LALNFLH R IIYRDLKLDNVLMD++GH+KLTDYGMCKEGI D+ +TFCGTPNYIAPEILR E Y SVDWW+LGVLMFEMLAG SPW GQ + ++N+EDYLF +ILT+PIR PRSIS +A++IL+ L K+P +RL C P SNF D NH+FFR ++W L K+I PP+RP +D DLT+FDP FTDEPV+FTPD++ +SKIDQ+EFEGFEY+NPLL+T EE V
Sbjct: 8 IPVKYIHNSIAMVTNLPSQADLKAMQSQVMELCQFSPDCRFTLKWIDEEQDPCVLSSDLELEEAVRLLHLNKECQLTVLVFDGIPLEPGKPCPGEDLSMYRRGAKRWKKKYYLLHGHKFAARRFNKNAECAYCHGRIWGLGQQGFKCITCRLLLHRRCRGCVQHKCGEPLTIPGPLNPVTVGRVTPLSPET---PNEFAYLNNNASANSRPTSYQLSHAGVETPNHNSGASRLEIAYAQQSTFEEERNRPRTGIQNPAFVDRPSDVEHTRKPRCTEISVPRPDVVIPILEERIAEMSVITTTSSSGQVGLQDFKLLKVIGRGSYAKVFQVEHIPTQRIYAMKVIKKETILDEEDIEWVQTEKHVFECATNHPFLVGLHSCFQTDSRLFFVIEFVNGGDLMFYMQRNLRLAEDYARFYSAEICLALNFLHERGIIYRDLKLDNVLMDSEGHIKLTDYGMCKEGITADVMTSTFCGTPNYIAPEILRGENYNFSVDWWALGVLMFEMLAGRSPWENVGQSVNQDQNSEDYLFQVILTRPIRFPRSISVRATNILRAFLTKNPAERLGCLPDSNFADIMNHSFFRPVDWVALEQKQIAPPYRPTYANDYDLTHFDPTFTDEPVVFTPDNEEVVSKIDQTEFEGFEYVNPLLMTLEEPV 659
BLAST of Protein kinase C vs. TrEMBL
Match: A0A1B6DB11 (Protein kinase C OS=Clastoptera arizonana OX=38151 GN=g.32058 PE=3 SV=1) HSP 1 Score: 706.442 bits (1822), Expect = 0.000e+0 Identity = 350/626 (55.91%), Postives = 433/626 (69.17%), Query Frame = 3
Query: 30 HESALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPV-DGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
HE I++K Y E IT I+ +T DQL E+ IC FTMKW+D+EGDPCTI+TQMELDEAIRLYE N+D+E+ +HVFP++P +PGMPCQGED +YRRGA+RW+K Y + GH F AKRFN+ A C +C+DRIWGLG+QG +C C+LL+HK+C +LV+ C + P I R NG NI+ P + EL D DL A + +++ + E G+ + + L DF L+ V+GRGSYAKV VE K T++IYAMKVIKK +TD +DI+WVQTEKHVFE ASNHPFLVGLHSCFQTPSRL +VIEFV GGDLM+HMQR+ R+PEEHA+FYAAEI+LALNFLH + IIYRDLKLDNVL+D++GH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVL++EMLAG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LKG LNK+P RL C + F D NHAFF+ ++W+ L K++ PP++P L DRDL NF P FTDEPV TPDD I KIDQSEFEGFEY+NPLL++ E+ V
Sbjct: 9 HEVPEIRVKTAYDGEIMITYIDPHITVDQLCQEMRDICRFSQDQVFTMKWVDEEGDPCTISTQMELDEAIRLYEINRDSELTIHVFPNVPPAPGMPCQGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAFCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKPCSNEVVEP-----------IIRDDANGDT--------PNINTPTSELLPELKDFPDPPLDLTADSVPIEDPTKSDD---------------------NLEPGS---QRQYSLADFELIRVIGRGSYAKVLMVELKKTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMFHMQRQRRLPEEHARFYAAEISLALNFLHDKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVKAASVLKGFLNKNPVDRLGCHRETGFYDIANHAFFKSIDWEMLEQKQVAPPYKPRLDSDRDLANFPPEFTDEPVHLTPDDTRVIEKIDQSEFEGFEYVNPLLMSLEDCV 591
BLAST of Protein kinase C vs. TrEMBL
Match: A0A564YUI6 (Protein kinase C OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS9332 PE=3 SV=1) HSP 1 Score: 706.057 bits (1821), Expect = 0.000e+0 Identity = 358/629 (56.92%), Postives = 427/629 (67.89%), Query Frame = 3
Query: 45 IKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRW-KKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGD--------RKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
++LK+ + TIT I++S + QL+ I + L FTMKW+DDEGDPC +T EL E+IRLY NK+ + +HVF P SPG+PC GED+K+YRRGAKRW KKFYHL GH F +RFNK A C YC+DRIWGLGQQG +C C+LL+HKRC V ++CGE P ++ + QR G + S DG G V ++ R S H+ A P E G G + +IGL +FNLL V+GRGSYAKVFQVEYK T KIYAMKVIKKE ITD +DI+WVQTEKHVFE ASNHPFLVGLHSCFQTPSRL +VIEF+NGGDLMYHMQR+ R+PE+HAKFYAAEI +A+NFLH R I+YRDLKLDNVLMD +GH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E+Y SVDWW+LGVLMFEM++G SPW G P++NTEDYLF +ILTKPIR PRSIS KAS+IL+ LNKDPT RL C P+SNF D QN FF ++W L K++ PPFRPE T + L +FDP FT+E V FTPDD I IDQSEF+GFEY+NPLL+ T E V
Sbjct: 1 MRLKVFHNGTTTITDIDSSFNFQQLQTSIQALYRLRPNDPFTMKWVDDEGDPCMLTCDEELQESIRLYHANKEPFLAVHVFNGAPPSPGLPCPGEDVKMYRRGAKRWNKKFYHLKGHNFVGRRFNKNAICAYCEDRIWGLGQQGYKCTNCKLLIHKRCAPSVDYRCGE--VAPPHE------VIRQRPVTVNGDAGANEMLIS------DGVANSGFVGSVRDATRTSHHKGAAV-----------------------PLPKAEVGDGSLIIPKVPVKSEQIGLENFNLLRVIGRGSYAKVFQVEYKSTSKIYAMKVIKKEIITDEEDIDWVQTEKHVFEIASNHPFLVGLHSCFQTPSRLFFVIEFINGGDLMYHMQRQCRLPEDHAKFYAAEICIAMNFLHERQIVYRDLKLDNVLMDLEGHIKLTDYGMCKEGISETNLTSTFCGTPNYIAPEILRGESYSFSVDWWALGVLMFEMVSGRSPWEGIGSSNNPDQNTEDYLFQVILTKPIRYPRSISVKASNILQRFLNKDPTDRLGCAPNSNFADIQNQPFFSSIDWVALEQKRVPPPFRPEETDEFSLIHFDPTFTNEEVCFTPDDPDVIRAIDQSEFDGFEYLNPLLIKTAETV 592
BLAST of Protein kinase C vs. TrEMBL
Match: A0A5K3FGB9 (Protein kinase C OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 704.516 bits (1817), Expect = 0.000e+0 Identity = 353/621 (56.84%), Postives = 434/621 (69.89%), Query Frame = 3
Query: 45 IKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRW-KKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
+KLK ++ TIT+I++SV + QL+ + + + FT+KW+DDEGDPC +T EL EA+RLY+ NK+ +++HVF P PGMPC GED K+YRRGAKRW KKFYHL GH F A+RFN+ A C YC+DRIWGLGQQG +C C+LL+HKRC V +CGE P ++ + QR G+ G EE+ I+++ + R A++ + + ++ PV +E ++GL F LL V+GRGSYAKVFQVEYKPT KIYAMKVIKKE ITD +DI+WVQTEKHVFE ASNHPFLVGLHSCFQTPSRL +VIEF+NGGDLMYHMQR LR+PEE+AKFYAAEI +ALNFLH R I+YRDLKLDNVLMD +GH+KLTDYGMCKEGI + +TFCGTPNYIAPEILR+E+Y SVDWW+LGVLMFEM++G SPW G P+ NTEDYLF +ILTKPIR PRSIS +AS+IL+ LNKDP +RL C P+SNF D QN FFR ++W L K++QPP+RPE D L +FDP FT+E V FTPDD I IDQSEF+GFEY+NPLL+ T E V
Sbjct: 8 MKLKFVFDGTITITEIDSSVDFQQLQLAVISLYHFSPETLFTLKWVDDEGDPCLLTGDSELREAVRLYQLNKEPFLLVHVFIGAPPEPGMPCPGEDCKMYRRGAKRWNKKFYHLKGHNFLARRFNRNAICAYCEDRIWGLGQQGYKCNACKLLIHKRCAPSVDFRCGE--VAPAHE------VVRQRPVTVNGV----------------GAEEMLVADGIQNNAFIASDREVYDSPASSRKNKQGAKAAPDALVIPEVPVKSE--------QVGLDHFKLLRVIGRGSYAKVFQVEYKPTGKIYAMKVIKKEIITDEEDIDWVQTEKHVFESASNHPFLVGLHSCFQTPSRLFFVIEFINGGDLMYHMQRHLRLPEEYAKFYAAEICIALNFLHERQIVYRDLKLDNVLMDLEGHIKLTDYGMCKEGISENNLTSTFCGTPNYIAPEILRSESYSFSVDWWALGVLMFEMVSGRSPWEGVGVSNNPDHNTEDYLFQVILTKPIRYPRSISVQASNILQRFLNKDPVERLGCPPNSNFADIQNQPFFRSIDWVALEQKRVQPPYRPEKADDYSLIHFDPTFTNEEVCFTPDDPEVIRAIDQSEFDGFEYLNPLLIKTAETV 596
BLAST of Protein kinase C vs. Ensembl Cavefish
Match: prkcz (protein kinase C zeta type [Source:NCBI gene;Acc:103044996]) HSP 1 Score: 488.419 bits (1256), Expect = 8.481e-166 Identity = 231/348 (66.38%), Postives = 278/348 (79.89%), Query Frame = 3
Query: 861 IGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
+GL DF+L+ V+GRGSYAKV V K + IYAMKV+KKE + D +DI+WVQTEKHVFE AS +PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH + IIYRDLKLDNVL+D DGH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTE+YLF +IL KPIRIPRS+S KA+S+LKG LNKDP +RL C+ + F D ++H FFR ++WD L K++ PPF+P++T D L NFD FT+EPV TPDD+ I +IDQSEFEGFEYINPLLL+ EE+V
Sbjct: 206 LGLADFDLIRVIGRGSYAKVLLVRLKKNEHIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPFLVGLHSCFQTESRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQVQTGFTDIKSHTFFRSIDWDQLEQKQVTPPFKPQITDDYGLDNFDTQFTNEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSNEESV 551 HSP 2 Score: 201.06 bits (510), Expect = 4.858e-56 Identity = 86/166 (51.81%), Postives = 118/166 (71.08%), Query Frame = 3
Query: 42 LIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
++K + + I+ +++ VT+ +L E+ +C + T+KWIDDEGDPCTI++QMELDEA R+Y NK + +++HVFPS+P PGMPC GED +YRRGA+RW+K Y + GH F AKRFN+ A C +C +RIWGLG+QG RC CRLL+HKRC +LV C
Sbjct: 1 MLKCCVCVCRDMLISDLDSGVTFSELCEEVRGMCRVHREQPITLKWIDDEGDPCTISSQMELDEAFRIYSRNKRSGLLLHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGHCSERIWGLGRQGYRCINCRLLVHKRCHKLVPLSC 166
BLAST of Protein kinase C vs. Ensembl Cavefish
Match: prkcz (protein kinase C zeta type [Source:NCBI gene;Acc:103044996]) HSP 1 Score: 489.96 bits (1260), Expect = 1.203e-165 Identity = 231/348 (66.38%), Postives = 278/348 (79.89%), Query Frame = 3
Query: 861 IGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
+GL DF+L+ V+GRGSYAKV V K + IYAMKV+KKE + D +DI+WVQTEKHVFE AS +PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH + IIYRDLKLDNVL+D DGH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTE+YLF +IL KPIRIPRS+S KA+S+LKG LNKDP +RL C+ + F D ++H FFR ++WD L K++ PPF+P++T D L NFD FT+EPV TPDD+ I +IDQSEFEGFEYINPLLL+ EE+V
Sbjct: 252 LGLADFDLIRVIGRGSYAKVLLVRLKKNEHIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPFLVGLHSCFQTESRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQVQTGFTDIKSHTFFRSIDWDQLEQKQVTPPFKPQITDDYGLDNFDTQFTNEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSNEESV 597 HSP 2 Score: 208.379 bits (529), Expect = 3.016e-58 Identity = 91/173 (52.60%), Postives = 124/173 (71.68%), Query Frame = 3
Query: 21 MKMHESALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
M++HE +K+K Y + I+ +++ VT+ +L E+ +C + T+KWIDDEGDPCTI++QMELDEA R+Y NK + +++HVFPS+P PGMPC GED +YRRGA+RW+K Y + GH F AKRFN+ A C +C +RIWGLG+QG RC CRLL+HKRC +LV C
Sbjct: 9 MEIHEE-YVKIKAHYGGDMLISDLDSGVTFSELCEEVRGMCRVHREQPITLKWIDDEGDPCTISSQMELDEAFRIYSRNKRSGLLLHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGHCSERIWGLGRQGYRCINCRLLVHKRCHKLVPLSC 180
BLAST of Protein kinase C vs. Ensembl Cavefish
Match: prkci (protein kinase C, iota [Source:NCBI gene;Acc:117507]) HSP 1 Score: 482.256 bits (1240), Expect = 2.157e-163 Identity = 229/354 (64.69%), Postives = 281/354 (79.38%), Query Frame = 3
Query: 843 GDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
G +GL DF+LL V+GRGSYAKV V K T++IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL++++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LKG LNK+P +RL C P + F D H FFR ++WD + K++ PPF+P ++ + L NFD FT+EP+ TPDD + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 193 GKATSSLGLADFDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLESEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKGFLNKEPKERLGCHPQTGFADIMAHPFFRNVDWDLMEQKQVVPPFKPNISGEFGLDNFDAQFTNEPIQLTPDDDDVVKKIDQSEFEGFEYINPLLMSAEECV 546 HSP 2 Score: 179.874 bits (455), Expect = 1.899e-48 Identity = 79/161 (49.07%), Postives = 109/161 (67.70%), Query Frame = 3
Query: 192 GDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTA--------ENGGIENPGYYVES 650
GDPCT+++Q+EL+EA+RLYE NKD+E+++HVFP +P PGMPC GED +YRRGA+RW+K Y+ GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG ++S ++ ++ T E GG +PG S
Sbjct: 38 GDPCTVSSQLELEEALRLYELNKDSELIIHVFPCIPEKPGMPCPGEDKSIYRRGARRWRKLYYANGHAFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTVECGRQMIQVRHESGLQWSIHKNSTESINHDEEHEAGGSRDPGKATSS 198
BLAST of Protein kinase C vs. Ensembl Cavefish
Match: prkceb (protein kinase C, epsilon b [Source:ZFIN;Acc:ZDB-GENE-081028-47]) HSP 1 Score: 356.681 bits (914), Expect = 1.380e-114 Identity = 198/517 (38.30%), Postives = 281/517 (54.35%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDF--------NLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKI--------GLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDD-FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLT 1889
HKFS + C +C +WGL +QGL+C C++ +H+RC+ V CG D +L +I S++ ++ G P P+ E + K D + + +R + + + E G ++ L DF+ + V+G+GS+ KV E + T ++YA+KV+KK+ I DD++ TEK + A HP+L L CFQT RL +V+E+VNGGDLM+ +QR + E ++FYAAE+ AL FLHR +IYRDLKLDN+L+D +GH KL D+GMCKEGI I TTFCGTP+YIAPEIL+ YG SVDWW+LGVLM+EM+AG QP P E + ED LF IL + P +S +A SILK + K P +RL C S ++ + H FF+ ++W L +KI+PPF+P + RD+ NFD FT E + TP D + I +I+Q EF+GF Y L+
Sbjct: 54 HKFSIHNYKVPTFCDHCGSLLWGLMRQGLQCKVCKMNVHRRCESNVAPNCGVDARGIAKVLSDLGVTPDKISSSVQRRKKISQGPDPQP---------LPISPQTEEDRSKSAPTSPCDQDAKDSENIRKALSFDHRGEELKPEAPSSLNEAGAEESGEARENSEVKTLQTKRMSLEDFSFIKVLGKGSFGKVMLAELRGTDEVYAVKVLKKDVILQDDDVDCTLTEKRILALARKHPYLTQLFCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHRNGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILDGITTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAG-----QP----PFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKSPNKRLGCVVSQGMEEAIKVHPFFKEIDWVLLEQRKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTPVDDAIIKQINQDEFKGFSYFGEEALS 552
BLAST of Protein kinase C vs. Ensembl Cavefish
Match: prkcba (protein kinase C beta [Source:NCBI gene;Acc:103036012]) HSP 1 Score: 343.199 bits (879), Expect = 5.691e-108 Identity = 166/346 (47.98%), Postives = 227/346 (65.61%), Query Frame = 3
Query: 858 KIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTE 1895
++ L DFN + V+G+GS+ KV E K T ++YA+K++KK+ + DD+E EK V + PFL LHSCFQT RL +V+E++NGGDLMY +Q+ + E HA FYAAEIA+ L FLH + IIYRDLKLDNV++D +GH+K+ D+GMCKE + + TFCGTP+YIAPEI+ + YG SVDWW+ GVL++EMLAG QP P + ED LF I+ + P+S+S +A +I KGL+ K P +RL C P D + HAFFR ++W+ L +K++QPPF+P+ RD NFD FT P + TP D+ I +DQ EF+GF Y+NP E
Sbjct: 335 RVKLSDFNFVMVLGKGSFGKVMLAERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALSGKPPFLTQLHSCFQTMDRLYFVMEYINGGDLMYQIQQVGKFKEPHAVFYAAEIAIGLFFLHSKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMLDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAG-----QP----PFDGEDEDELFQSIMEHHVSYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGE-RDIKEHAFFRYMDWEKLQNKEVQPPFKPKAC-GRDAENFDRFFTRHPPVLTPPDQEVILNLDQEEFQGFSYVNPEYAAQE 669 HSP 2 Score: 67.781 bits (164), Expect = 2.573e-11 Identity = 31/82 (37.80%), Postives = 44/82 (53.66%), Query Frame = 3
Query: 297 PTSPG-MPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
P +PG +G R+GA R K + + HKF A+ F + C +C D IWG G+QG +C C ++HKRC + V C
Sbjct: 4 PAAPGDAESEGGARGFARQGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 85
BLAST of Protein kinase C vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008480.1 (pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1 gene:ENSPMAG00000007654.1 transcript:ENSPMAT00000008480.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 286.96 bits (733), Expect = 1.806e-89 Identity = 137/324 (42.28%), Postives = 203/324 (62.65%), Query Frame = 3
Query: 852 KGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLH-RRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDK 1820
K K+ + +F+ L ++G+G++ KV V K T + YAMK++KKE I D++ TE V + + HPFL L FQT RL +V+E+VNGG+L +H+ R+ E+ +FY AEI AL++LH + ++YRDLKL+N+++D DGH+K+ D+G+CKEGI TFCGTP Y+APE+L + YG +VDWW LGV+M+EM+ G P+ + LF LIL + IR PR++S A ++L GLL KDP QRL + + H+FF G+ W D+ D+K+ PPF+P++ + D FD FT + + TP D+
Sbjct: 142 KSKVTMNNFDYLKLLGKGTFGKVILVREKATGQYYAMKILKKEVIVAKDEVAHTLTENRVLQ-TTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN---------QDHEKLFELILMEDIRFPRTLSNDARALLSGLLKKDPKQRLGGG-VDDAKEIMRHSFFAGIIWQDVYDRKMTPPFKPQVASETDTRYFDEEFTAQTITITPPDR 454
BLAST of Protein kinase C vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006766.1 (pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 gene:ENSPMAG00000006086.1 transcript:ENSPMAT00000006766.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 279.641 bits (714), Expect = 2.062e-87 Identity = 146/368 (39.67%), Postives = 219/368 (59.51%), Query Frame = 3
Query: 816 PPVDTEGGTGDRKGKIGLG----------DFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMF----TPDDKSKISKIDQS--EFEGFEYI 1871
P T+G + I LG DF+ L V+G+GS+ KV ++K YA+KV+KK I + + + E++V HPFLVGLH FQ+ +L +V+++VNGG+L +H+QR+ PE A+FYAAEI A+ +LH I+YRDLK +N+L+D GH+ LTD+G+CKEGI+ TFCGTP Y+APE+L+ Y +VDWW LG +++EML G P+ +N + ++ IL +P+++ + A S+L+GLL+KDP QRL +S+ + +NH FF +NW+DL K+I P+ P ++ DL NFDP FT EP+ + D S + +D++ F GF Y+
Sbjct: 62 PRNQTQGPMENDADHINLGPSANLQAKPSDFDFLTVLGKGSFGKVLLAKHKSDGIFYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFY--------SKNLKQ-MYESILHQPLQLRPCTTNAAISVLEGLLHKDPHQRLGA--TSDILEIKNHVFFSTINWNDLDAKRIPSPYNPGVSGPCDLHNFDPAFTAEPLSMSMAQSSDTSSVCANVDEAADAFVGFTYM 418
BLAST of Protein kinase C vs. Ensembl Sea Lamprey
Match: PRKCD (protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399]) HSP 1 Score: 271.166 bits (692), Expect = 7.082e-83 Identity = 141/311 (45.34%), Postives = 189/311 (60.77%), Query Frame = 3
Query: 819 PVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLR--MPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPEL 1745
P ++ +G+ GK+ L F+LL V+G+GS+ KV E K K +A+K +KKE + DD+E EK V A HPFL L FQT L +V+EF+ GGDLM+H+Q K + +P +FYAAE+ L FLH IIYRDLKLDNVL+D +GH+K+ D+GMCKE + ATTFCGTP+YIAPEIL AYG SVDWWS+GVL++EML G SP+ + ED LF I PR +S + +IL L +D T+RL D + H FF+ ++W L +KI PPF+P++
Sbjct: 233 PDESTRPSGEIAGKLSLDHFHLLKVLGKGSFGKVMLAELKEQGKFFAIKALKKEVVLMGDDVECTMVEKRVLLMACEHPFLTHLCGTFQTKEHLFFVMEFLTGGDLMFHIQDKGKFDLPTGTNRFYAAEVICGLQFLHSHNIIYRDLKLDNVLLDREGHVKIADFGMCKEHVGAGNLATTFCGTPDYIAPEILLGRAYGTSVDWWSMGVLIYEMLIGQSPFYG---------SDEDELFEAIKGHTPHYPRWLSDSSRNILSCLFERDHTKRLG-----AVGDIRLHPFFKNIDWPSLEARKITPPFKPKV 529 HSP 2 Score: 52.7582 bits (125), Expect = 2.029e-7 Identity = 28/78 (35.90%), Postives = 39/78 (50.00%), Query Frame = 3
Query: 345 RRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQI 578
RRGA + K + GH F F + C CK+ +WGL +QG +C C HKRC V +C + N Q++I
Sbjct: 2 RRGAIKQAKVKFVKGHAFVTTFFPQPTFCSVCKEFVWGLNKQGFQCKECNASSHKRCVDNVLARCTGSADT-NRQTEI 78
BLAST of Protein kinase C vs. Ensembl Sea Lamprey
Match: PRKCD (protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399]) HSP 1 Score: 256.144 bits (653), Expect = 1.772e-80 Identity = 127/279 (45.52%), Postives = 177/279 (63.44%), Query Frame = 3
Query: 915 KVFQVEYKPT-KKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELT 1748
+VF E K + +A+K +KK+ + SDD+E EK + A HP+L L+S FQT L++V+E++NGGDLM+H+Q K R + A FYAAEI L FLH + IIYRDLKLDN+L+D DGH+K+ D+GMCKE I GD++A TFCGTP+YIAPEI+ + Y SVDWWS GVL++EML G SP+ + E+ LF I T PR I+ + IL LL ++P +RL + + H FFR +NW+ L ++++PPF+P +
Sbjct: 1 QVFLAELKSRPRNFFAIKALKKDVVIMSDDVECTLVEKRILSLAWGHPYLAHLYSTFQTKEHLMFVMEYLNGGDLMFHIQVKGRFEIDRATFYAAEIVSGLQFLHDQGIIYRDLKLDNILLDKDGHVKIADFGMCKENIVGDVRAGTFCGTPDYIAPEIVIGQKYNCSVDWWSFGVLLYEMLIGQSPF---------RGDDEEELFESIRTSVPYYPRWITKDSRDILPLLLEREPMKRLGVT-----GEIRQHPFFRTINWEALEKRELEPPFKPRVV 265
BLAST of Protein kinase C vs. Ensembl Sea Lamprey
Match: sgk1 (serum/glucocorticoid regulated kinase 1 [Source:NCBI gene;Acc:324140]) HSP 1 Score: 191.045 bits (484), Expect = 3.775e-55 Identity = 118/344 (34.30%), Postives = 183/344 (53.20%), Query Frame = 3
Query: 873 DFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTP---NYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEP----VMFTPDDKSKISKIDQSE--FEGFEYINP 1877
DF+ L ++G+GS+ KV + K +K YA+KV++K+ I + + + E++V HPFLVGLH FQT +L +V++++NGG++ + K Y E LN LH I RDLK +N+L+D +GH+ LTD+G+CKEGI+ + +TFCGTP + + +R++ + W C+ W + GQ + + F ++ R +IS A +L+GLL+KD TQRL S +F + + H FF +NW+DL+ KKI PPF P + DL +FDP F EP V +P + + + ++ F GF Y P
Sbjct: 8 DFDFLKIIGKGSFGKVLLAKLKTDEKFYAVKVLQKKAILKKKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTADKLYFVLDYINGGEVRTSTCAPCIVVHHKWKGYREEPIDELNSLHFVNQISRDLKPENILLDFEGHIILTDFGLCKEGIQPNDTTSTFCGTPEESDLTNRKEIRSQRSSRTRGW----------DLRCA-W-RAGQVTTHRPSVSEVSFVPSFSQSRRFKPNISNSARDLLEGLLHKDRTQRLGA--SGDFTEIKGHVFFSPINWEDLLSKKIVPPFNPNVNGPSDLRHFDPEFISEPVPGSVCRSPGEFAVSASFQEARDAFAGFSYAPP 337
BLAST of Protein kinase C vs. Ensembl Yeast
Match: PKC1 (Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) [Source:SGD;Acc:S000000201]) HSP 1 Score: 273.478 bits (698), Expect = 1.706e-79 Identity = 138/343 (40.23%), Postives = 214/343 (62.39%), Query Frame = 3
Query: 849 RKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASN--HPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYI 1871
++ K+ L +F LL V+G+G++ KV + K T ++ A+KV+KK+ I + DIE + EK VF A+ HPFL L+ FQT +R+ + +EF+ GGDLM+H+Q + R+ AKFYAAE+ LAL + H +IYRDLKL+N+L+ +GH+K+ DYG+CK+ + + +TFCGTP ++APEIL+ + Y +VDWW+ GVL+++ML SP+ + ED +FN ILT P ++ + I +GLL KDP +RL P + D+ FFR +N+DD+++ +++PP+ PE+ D + F+ FT P TP S ++ Q EF GF ++
Sbjct: 815 KRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQNQ-RLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIKIADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPF---------SGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGAGP-RDADEVMEEPFFRNINFDDILNLRVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTP-LPSVLTTSQQEEFRGFSFM 1145
BLAST of Protein kinase C vs. Ensembl Yeast
Match: YPK1 (S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000001609]) HSP 1 Score: 263.462 bits (672), Expect = 1.038e-78 Identity = 134/342 (39.18%), Postives = 208/342 (60.82%), Query Frame = 3
Query: 849 RKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDE-PVMFTPDDKSKISKIDQSEFEGFEYI 1871
R + + DF+LL V+G+GS+ KV QV K T+K+YA+K I+K +I ++ E+ V + PF+V L FQ+P +L +V+ F+NGG+L YH+Q++ R A+FY AE+ AL+ LH+ ++YRDLK +N+L+D GH+ L D+G+CK ++ D K TFCGTP Y+APE+L Y +VDWW+LGVL++EML G P+ + +P ++ IL +P+ P A +L GLL++DPT+RL + D+ +NH FF L+W L+ K PP++P +++ D +NFD FT E P+ D+ +S+ Q +F G+ Y+
Sbjct: 338 RNKPLSIDDFDLLKVIGKGSFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVL-ARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYD--EDVPK-------MYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGYNGA---DEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDEEFTREKPIDSVVDE--YLSESVQKQFGGWTYV 664
BLAST of Protein kinase C vs. Ensembl Yeast
Match: YPK2 (Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000004710]) HSP 1 Score: 258.455 bits (659), Expect = 6.693e-77 Identity = 130/337 (38.58%), Postives = 205/337 (60.83%), Query Frame = 3
Query: 861 IGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYI 1871
+ + DF+LL V+G+GS+ KV QV K T+KIYA+K ++K +I ++ E+ V + PF+V L FQ+P +L V+ F+NGG+L YH+Q + R ++FY AE+ AL+ LH+ +IYRDLK +N+L+D GH+ L D+G+CK ++ + K TFCGTP Y+APEIL + Y +VDWW+LG+L++EM+ G P+ + +P ++ IL +P+ P P A +L GLL++DP++RL + D+ +NH FF+ ++W L+ K PP++P + + D NFD FT E + + D+ + I Q +F G+ YI
Sbjct: 339 LSIDDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVL-ARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYD--ENVP-------VMYKKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRLGVNGT---DEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFDQEFTKEKPIDSVVDEYLSASI-QKQFGGWTYI 661
BLAST of Protein kinase C vs. Ensembl Yeast
Match: SCH9 (AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan [Source:SGD;Acc:S000001248]) HSP 1 Score: 244.973 bits (624), Expect = 9.501e-71 Identity = 133/354 (37.57%), Postives = 211/354 (59.60%), Query Frame = 3
Query: 849 RKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVF--ECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNE-AYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSI-SPKASSILKGLLNKDPTQRLACKPSSNFDD---FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDK-----SKISKIDQSEFEGFEYIN 1874
+K G DF +L ++G+G++ +V+QV+ K T++IYAMKV+ K+ I ++I E+++ + + PF+VGL FQTP+ L V ++++GG+L +H+Q++ R E+ AKFY AE+ LAL LH I+YRDLK +N+L+D +G++ L D+G+ K ++ + TFCGT Y+APE+L +E Y VD+WSLGVL+FEM G SP+ EN + ++ I ++ PR + S + S +KGLLN++P RL DD + H FF ++W+ L KKI PPF+P L + D +NFDP FT + + + +S Q++F GF +++
Sbjct: 403 KKRHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLKD--RTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFF--------AENNQK-MYQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGA-----IDDGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFDPEFTTASTSYMNKHQPMMTATPLSPAMQAKFAGFTFVD 740
BLAST of Protein kinase C vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 214.157 bits (544), Expect = 3.033e-63 Identity = 113/311 (36.33%), Postives = 177/311 (56.91%), Query Frame = 3
Query: 846 DRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDR-DLTNFD 1775
D GK L DF +L +G GS+ +V + + YA+K +KK I +E E+ + S HPF++ + FQ ++ V++++ GG+L +++ R P AKFYAAE+ LAL +LH + IIYRDLK +N+L+D +GH+K+TD+G K D+ T CGTP+YIAPE++ + Y SVDWWS GVL++EMLAG +P+ NT N IL ++ P P A +LK L+ +D ++RL + + +D +NH +F + W+ L+ + I+ P+ P + + D + FD
Sbjct: 78 DTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVS-HPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK--YVPDV-TYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYN--------SNTMKTYEN-ILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGS-EDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFD 374
BLAST of Protein kinase C vs. Ensembl Nematostella
Match: EDO44938 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU22]) HSP 1 Score: 496.508 bits (1277), Expect = 3.595e-169 Identity = 231/348 (66.38%), Postives = 280/348 (80.46%), Query Frame = 3
Query: 861 IGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
I + DFNL+ V+GRGSYAKV VE K TK+IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+V+GGDLMYHMQR+ R+PE+HA+FY+AEI ALNFLH + +IYRDLKLDNVL+D+DGH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVL++EMLAG SP+ G P++NTEDYLF +IL KPIRIPRS+S KA+SILKG LNK+PT+RL C P + F D +HAFFR ++W+ L +++ PPF+P L NFDP FT+E V FTPDD + IDQ+EFEGFEYINPLL++ E++V
Sbjct: 217 ISVNDFNLIRVIGRGSYAKVMLVELKKTKRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTSSRLFFVIEYVSGGDLMYHMQRQRRLPEDHARFYSAEICCALNFLHEKGVIYRDLKLDNVLLDSDGHIKLTDYGMCKEGIRPGDVTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDIVGSADNPDQNTEDYLFQVILEKPIRIPRSLSVKAASILKGYLNKNPTERLGCHPQTGFADITSHAFFRTVSWEQLEARQVTPPFKPRQEDPYGLENFDPQFTNEDVQFTPDDPKMLETIDQTEFEGFEYINPLLMSVEDSV 564 HSP 2 Score: 181.03 bits (458), Expect = 3.404e-49 Identity = 75/175 (42.86%), Postives = 116/175 (66.29%), Query Frame = 3
Query: 27 MHESALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDF 551
M+ ++ I ++ Y + ++ ++ D ++ I FT+KW+D+EGDPCTI++Q EL+EAIRLYE N+D+E+++H+F P PG C GE +YRRGAKRW+K + + GH F AKRF++ A C +C DRIWGLG+ G +C C+L++HK+C +L+K +CG+
Sbjct: 2 MNSTSAIAVRAAYNGDIMCLSMDPHISLDTFTEDMKDIFKFRKEQTFTLKWLDEEGDPCTISSQEELNEAIRLYEINRDSELVVHLFLGEPQYPGQLCNGETRNIYRRGAKRWRKIHIVNGHSFVAKRFSRLAACAFCSDRIWGLGRSGYKCLECKLVVHKKCHKLIKIQCGQQL 176
BLAST of Protein kinase C vs. Ensembl Nematostella
Match: EDO35585 (Protein kinase C [Source:UniProtKB/TrEMBL;Acc:A7SL27]) HSP 1 Score: 369.392 bits (947), Expect = 5.501e-118 Identity = 199/503 (39.56%), Postives = 290/503 (57.65%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAI---QRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKG----KIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINP 1877
HKF K +N+ C C ++G+ +QG++C C++ +H+RC Q V + CG + P ++I + I + E+ I+ P ++ +N K + + V+ + + N + L + P G+R+ K+ L DF + V+G+GS+ KV E K T ++YA+K++KKE + DD+E E+ V ++ HPFL LHS FQT RL +V+E+VNGGDLM+ +Q+ + E ++FYAAE+ LAL FLH+ +IYRDLKLDNVL+D DGH+KL D+GMCKE + TTFCGTP+YIAPEIL+ + YG SVDWW+LGVLM+EM+AG P+ EN ED LF IL + P +S +A SILKG + K+ +RL C P+S + HAFFR +N++ L ++I PPF+P++ D+ NFD FT E TP D++ I IDQ EF GF ++NP
Sbjct: 241 HKFEKKSYNRPTFCELCGSLLYGIVRQGMQCTVCKMNVHRRCHQNVANNCGIN---PKKMAEILEEIGISPDRIHEESQQIKKPSFHDCTN-----------------KPAKKMTPRSVSSPSMMESVNENGLPGSTFKLESHQTSP-------GERRRHVLRKMTLKDFTFIKVLGKGSFGKVLLAERKGTDEVYAIKILKKESVLQDDDVECTMIERRVLALSAGHPFLTSLHSSFQTVERLFFVMEYVNGGDLMFQIQKSRKFDENRSRFYAAEVVLALQFLHQNGVIYRDLKLDNVLLDADGHIKLADFGMCKENMAPGKTTTTFCGTPDYIAPEILQEQPYGFSVDWWALGVLMYEMMAGQPPF--------EAENEED-LFESILHDDVLYPVWLSREAVSILKGFMTKNYLKRLGCTPTSTESSIREHAFFRLINFEKLEARQINPPFKPKIRSRTDVGNFDTDFTKEEPKLTPTDRNVIVNIDQREFRGFSFVNP 707 HSP 2 Score: 53.5286 bits (127), Expect = 2.299e-7 Identity = 22/56 (39.29%), Postives = 33/56 (58.93%), Query Frame = 3
Query: 375 YHLYGHKFSAKRFNKYAECFYCKDRIWG-LGQQGLRCGTCRLLLHKRCQQLVKHKC 539
+ + HKF A + C +C D IWG +G+QG +C C ++HKRC ++V KC
Sbjct: 161 HQINSHKFMATYLRQPTFCSHCNDFIWGVIGKQGYQCQVCTCVVHKRCHKMVVTKC 216
BLAST of Protein kinase C vs. Ensembl Nematostella
Match: EDO37800 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEW2]) HSP 1 Score: 293.893 bits (751), Expect = 9.007e-93 Identity = 148/341 (43.40%), Postives = 214/341 (62.76%), Query Frame = 3
Query: 873 DFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEP----VMFTPDDKSKISKIDQSE--FEGFEYINP 1877
DF L V+G+GS+ KVF + K K YA+KV+ K I ++ + + E++V HPFLVGLH FQT +L +V+++VNGG+L +H+QR+ PE A+FYAAEIA A+ +LH IIYRDLK +N+L+D+ GH+ LTD+G+CKEGI+ +TFCGTP Y+APE+LR + Y SVDWW LG +++EM+ G P+ + E +++ IL KP+R+ +IS A IL+GLL KD T+RL +F+D + H+FFR +NW LV + I+PP+ P ++ DL +FDP F EP V + D + +D + F GF Y+ P
Sbjct: 73 DFLFLKVIGKGSFGKVFLSKNKQEDKFYAIKVLNKSAIRKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGIDRSGTTSTFCGTPEYLAPEVLRKQDYDKSVDWWCLGAVLYEMMYGLPPFYS-------RDTAE--MYDNILHKPLRLRTNISQSARHILEGLLQKDKTKRLGSG-EGDFEDIRTHSFFRSINWQQLVARGIEPPYNPNVSGQLDLKHFDPEFVREPVPGSVGKSADSNFVSASVDDPDDAFVGFTYVAP 403
BLAST of Protein kinase C vs. Ensembl Nematostella
Match: EDO41166 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S521]) HSP 1 Score: 261.151 bits (666), Expect = 3.168e-80 Identity = 137/349 (39.26%), Postives = 214/349 (61.32%), Query Frame = 3
Query: 858 KIGLGDFNLLCVVGRGSYAKVFQVEYK---PTKKIYAMKVIKKEFITDSD-DIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTT 1892
K+G F LL V+G+G Y KVF V+ +KI+AMKV+KK I S D + E+++ EC HPF+V L FQT +L ++E+++GG+L ++R+ E+ A FY +EI++AL LH++ I+YRDLK +N+L+D +GH+KLTD+G+CKE I + TFCGT Y+APEIL +G +VDWWSLG LM++ML G P+ + + IL + IP ++P+A ++ LL + P RL + + + + H+FFR + W+DL+ KK++PPFRP ++ + D++ FD FT + + +PDD S +S+ + F+GF Y+ P +L +
Sbjct: 59 KVGPESFELLKVLGKGGYGKVFLVKKNHGHSKEKIFAMKVLKKAAIIRSQKDTAHTKAERNILECV-KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCA---------DNRKKTIDKILKGKLIIPPYLTPEAKDFIRKLLKRHPQARLGGM-AGDANPIKAHSFFRHICWEDLLAKKVEPPFRPSISGEEDVSQFDSKFTRQTPVDSPDD-SMLSESASNIFQGFTYVAPSVLES 395
BLAST of Protein kinase C vs. Ensembl Nematostella
Match: EDO39163 (Ribosomal protein S6 kinase [Source:UniProtKB/TrEMBL;Acc:A7SAZ2]) HSP 1 Score: 251.521 bits (641), Expect = 2.933e-73 Identity = 132/354 (37.29%), Postives = 209/354 (59.04%), Query Frame = 3
Query: 858 KIGLGDFNLLCVVGRGSYAKVFQVEYKPTK---KIYAMKVIKKEFITD-SDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKE--GIEGDIKATTFCGTPNYIAPEILRNEAYG--ASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTE 1895
K+G+ +F LL V+G G+Y KVF + +++AMKV+KK I + E +TE+ V E PFLV LH FQT ++L ++++VNGG+L H+ ++ + E+ + Y EI +AL+ LH+ IIYRD+KL+N+L+D DGH+ LTD+G+ KE +A +FCGT Y+APE+++ + G +VDWWSLGVLM+E+L G SP+ G E+N++ + IL +P +S +A +L LL KDP +RL K + + + H FF+ +W DL +K+I PF+P + + D++NF FTD ++P + + K F G+ ++ P ++ E
Sbjct: 10 KVGIENFELLRVLGTGAYGKVFLARKRGGHHDGRLFAMKVLKKATIVQKAKTAEHTRTERQVLEAVRRCPFLVTLHWAFQTEAKLHLIMDYVNGGELFTHLYQREKFTEDEVRLYIGEIVVALDHLHQLGIIYRDIKLENILLDKDGHVVLTDFGLSKEFAAPNSGERAYSFCGTIEYMAPEVVKGGSRGHDKAVDWWSLGVLMYELLTGASPFTVDG-----EKNSQSEISKRILHNNPPMPHDLSAEAIDLLHKLLQKDPKKRLGAKGAH---ELKAHPFFKAFDWADLAEKRIPAPFKPRIRDELDVSNFSEEFTDMAPTYSP---AAVPKTADRVFRGYSFVAPSIIFGE 352 HSP 2 Score: 119.783 bits (299), Expect = 5.100e-28 Identity = 80/261 (30.65%), Postives = 135/261 (51.72%), Query Frame = 3
Query: 891 VVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVL-MDN--DGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEIL----RNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIP----RSISPKASSILKGLLNKDPTQRLACK 1640
V+G GS++ + + + + YA+K+I + D VQ+ K HP +V L+ +Q V+E + GG+L+ +++K E A +I A+ F+H+R +++RDLK +N+L +DN D +K+ D+G E + T C T +Y APE+L N Y S D WSLGV+++ ML+G P+ G +++ ++ I +R +SISP+A +++GLL DP+QRL +
Sbjct: 401 VLGDGSFSTCRRCVHLRSGQEYAVKIISRR----CDHTREVQSLK----MCHGHPNIVTLYDVYQDEFHTYLVMELLAGGELLERIRKKKMFTESAASVIMRKIVSAVEFMHQRGVVHRDLKPENLLFVDNSEDAEIKIVDFGFACVKPEAQ-QLQTPCFTLSYAAPEVLDQTVSNSGYDESCDLWSLGVILYTMLSGQVPFQSSGSWY---KSSTGFVMQRITQGDVRFDGQQWQSISPQAKDLIQGLLTVDPSQRLTVQ 649
BLAST of Protein kinase C vs. Ensembl Medaka
Match: prkcz (protein kinase C zeta [Source:NCBI gene;Acc:101164401]) HSP 1 Score: 665.996 bits (1717), Expect = 0.000e+0 Identity = 328/624 (52.56%), Postives = 423/624 (67.79%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKG-KIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
S ++K+K + + IT + ASVT+ QL E+ +C + T+KWIDDEGDPCTI++QMELDEA R+Y + + +++HVFPS+P PG+PC GED +YRRGA+RW+K Y + GH F AKRFN+ A C +C +RIWGLG QG +C TC+LL+HKRC +L+ C QS + M Q + E +D P D E+ Q+ + H+ A + VD G +G + L DF L+ V+GRGSYAKV V K ++++AMKV+KKE + D +DI+WVQTEKHVFE AS +PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH + IIYRDLKLDNVL+D++GH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTE+YLF +IL KPIRIPRS+S KA+S+LKG LNKDP +RL C+ + F D ++H FFR ++W L K++ PPF+P+++ + L NFD FT+EPV TPDD+ I +IDQSEFEGFEYINPLLLTTEE++
Sbjct: 15 SKVVKIKAHFRGDMLITDLPASVTFLQLCAEVKSMCSVAKQQPITLKWIDDEGDPCTISSQMELDEAFRIYSRTRRSGLLLHVFPSIPERPGLPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGHCAERIWGLGTQGYKCITCKLLVHKRCHRLLPQTC---------QSLMDPVMPSQEPLSDAQSEE--------VDPPADDTEDADQIPFLPHNCVEEKTEDA-------------------ETEDIKAVVDGLDGIKLSQGVTLKLSDFELIRVIGRGSYAKVLLVRLKKNEQVFAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPFLVGLHSCFQTDSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQVQTGFTDIKSHTFFRSIDWQQLEKKEMTPPFKPQISDEFGLENFDTQFTNEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLTTEESI 600
BLAST of Protein kinase C vs. Ensembl Medaka
Match: prkcz (protein kinase C zeta [Source:NCBI gene;Acc:101164401]) HSP 1 Score: 658.677 bits (1698), Expect = 0.000e+0 Identity = 325/609 (53.37%), Postives = 413/609 (67.82%), Query Frame = 3
Query: 81 ITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKG-KIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
IT + ASVT+ QL E+ +C + T+KWIDDEGDPCTI++QMELDEA R+Y + + +++HVFPS+P PG+PC GED +YRRGA+RW+K Y + GH F AKRFN+ A C +C +RIWGLG QG +C TC+LL+HKRC +L+ C QS + M Q + E +D P D E+ Q + H+L VD G +G + L DF L+ V+GRGSYAKV V K ++++AMKV+KKE + D +DI+WVQTEKHVFE AS +PFLVGLHSCFQT SRL VIE+VNGGDLM+HMQR+ ++PEEHA+FYAAEI +ALNFLH + IIYRDLKLDNVL+D++GH+KLTDYGMCKEGI +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ P+ NTE+YLF +IL KPIRIPRS+S KA+S+LKG LNKDP +RL C+ + F D ++H FFR ++W L K++ PPF+P+++ + L NFD FT+EPV TPDD+ I +IDQSEFEGFEYINPLLLTTEE++
Sbjct: 39 ITDLPASVTFLQLCAEVKSMCSVAKQQPITLKWIDDEGDPCTISSQMELDEAFRIYSRTRRSGLLLHVFPSIPERPGLPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGHCAERIWGLGTQGYKCITCKLLVHKRCHRLLPQTC---------QSLMDPVMPSQEPLSDAQSEE--------VDPPADDTEDADQSETQHHNL-----------------------------------VDGLDGIKLSQGVTLKLSDFELIRVIGRGSYAKVLLVRLKKNEQVFAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPFLVGLHSCFQTDSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIITDN--PDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQVQTGFTDIKSHTFFRSIDWQQLEKKEMTPPFKPQISDEFGLENFDTQFTNEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLTTEESI 593
BLAST of Protein kinase C vs. Ensembl Medaka
Match: prkci (protein kinase C iota [Source:NCBI gene;Acc:101165764]) HSP 1 Score: 504.212 bits (1297), Expect = 6.489e-172 Identity = 232/355 (65.35%), Postives = 283/355 (79.72%), Query Frame = 3
Query: 840 TGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
G +GL DF+LL V+GRGSYAKV V+ K T++IYAMKV+KKE + D +DI+WVQTEKHVFE ASNHPFLVGLHSCFQT SRL +VIE+VNGGDLM+HMQR+ ++PEEHA+FY+AEI+LALN+LH R IIYRDLKLDNVL+D++GH+KLTDYGMCKEG+ +TFCGTPNYIAPEILR E YG SVDWW+LGVLMFEM+AG SP+ G P++NTEDYLF +IL K IRIPRS+S KA+S+LKG LNKDP +RL C P + F D H FFR ++WD L K++ PPF+P ++ + L NFD FT+EP+ TPDD+ + KIDQSEFEGFEYINPLL++ EE V
Sbjct: 200 AGKSPSSLGLADFDLLRVIGRGSYAKVLLVQLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILNKQIRIPRSLSVKAASVLKGFLNKDPKERLGCHPQTGFADITGHPFFRNVDWDLLQQKQVVPPFKPNISGEFGLDNFDAQFTNEPIQLTPDDEDVVKKIDQSEFEGFEYINPLLMSAEECV 554 HSP 2 Score: 179.489 bits (454), Expect = 2.731e-48 Identity = 77/169 (45.56%), Postives = 113/169 (66.86%), Query Frame = 3
Query: 36 SALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCG 542
S +++K Y + IT S++Y+ L E+ +C + + FTMKWID+EGDPCT+++Q+EL+EA+RLYE NKD+E+++H ++ +YRRGA+RW+K Y+ GH F AKRFN+ A C C DRIWGLG+QG +C C+LL+HK+C +LV +CG
Sbjct: 16 SHQVRVKAYYKGDIMITHFEPSISYEGLSGEVRDMCSMENDQLFTMKWIDEEGDPCTVSSQLELEEALRLYELNKDSELIIH--------------AAEVSIYRRGARRWRKLYYASGHVFQAKRFNRRAHCAICSDRIWGLGRQGYKCINCKLLVHKKCHKLVTMECG 170
BLAST of Protein kinase C vs. Ensembl Medaka
Match: prkceb (protein kinase C epsilon type [Source:NCBI gene;Acc:101172355]) HSP 1 Score: 357.451 bits (916), Expect = 1.940e-112 Identity = 200/527 (37.95%), Postives = 301/527 (57.12%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDF------------------NLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHR------VAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGG--TGDRKG-------KIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDD-FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEY 1868
H FS F C +C +WGL +QGL+C C++ +H+RC+ V CG D N + ++ Q++ E+ +S P D +++ ++++I+ L + DHR + ++ ++ A+ ++ G + +S D EG G+ KG ++ L DF + V+G+GS+ KV E K T +++A+KV+KK+ I DD++ TEK + A HP+L L+ CFQT RL +V+E+VNGGDLM+ +QR + E ++FYAAE+ AL FLHR ++YRDLKLDN+L+D +GH KL D+GMCKEGI + TTFCGTP+YIAPEIL+ YG SVDWW+LGVLM+EM+AG QP P E + ED LF IL + P +S +A SIL+ + K P++RL C + ++ + H FFR ++W L ++K++PPF+P + RD+ NFD FT E + TP D + + +I+Q EF+GF Y
Sbjct: 245 HMFSIHNFKVLTFCDHCGSLLWGLLRQGLQCKVCKVNVHRRCESNVAPNCGVDARGIAKVLSDLGVTPDKISNSAQRRKKLPQTQDAQQSLSEAQTEDD--RSKSAPTSPCD--QDVKELENIRKAL-SFDHRGEELTTLPLSSSSSIATVTCDTHEGEGGAEENSAGGDAEGSQENGEVKGPSAPETKRMNLHDFVFIKVLGKGSFGKVMLAELKGTDEVFAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHRHGVVYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELDYGPSVDWWALGVLMYEMMAG-----QP----PFEADNEDDLFESILHDDVLYPVWLSKEAVSILRAFMTKSPSKRLGCVAAQGLEEAIKVHPFFREIDWTLLEERKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTPVDDTIVKQINQDEFKGFSY 757 HSP 2 Score: 62.3882 bits (150), Expect = 1.232e-9 Identity = 28/67 (41.79%), Postives = 42/67 (62.69%), Query Frame = 3
Query: 345 RRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWG-LGQQGLRCGTCRLLLHKRCQQLVKHKCG 542
R+GA R ++ + + GHKF A + C +C+D IWG LG+QG +C C ++HKRC +L+ KC
Sbjct: 156 RQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELIITKCA 221
BLAST of Protein kinase C vs. Ensembl Medaka
Match: prkcha (protein kinase C eta [Source:NCBI gene;Acc:101158986]) HSP 1 Score: 354.369 bits (908), Expect = 3.835e-112 Identity = 192/500 (38.40%), Postives = 275/500 (55.00%), Query Frame = 3
Query: 390 HKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFD-DFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLL 1886
HKF+ + C +C +WG+ +QGL C C++ +H RCQ V CG + ++ + T G++ G + I VK+ + ++ RV+ R +T T + + ++G+ +F L V+G+GS+ KV + ++++A+KV+KK+ I DD+E TEK V A HP+L L+ CFQTP RL +V+EFVNGGDLM+H+Q+ + E A+FY AEI AL FLH + IIYRDLKLDNVL+D DGH KL D+GMCKE I TFCGTP+YIAPEIL+ YGASVDWW+LGVL++EML+G +P+ E ED LF IL + I +S +A ILK LL K+P +RL C + + +H FF G++W+ L +++++PPF+P + D+ NFDP FT E TP D I ++Q EF F + +P LL
Sbjct: 241 HKFNHHNYKSPTFCDHCGSLLWGIVRQGLHCKICKMNVHIRCQGNVAPNCGVN------------SVELANTLAEMGLQAGGLSKRNTI------------VKNATNS-QSEKQRVSSERREST----------------------TSTESRQQMPRLGISNFTFLQVLGKGSFGKVMLAKLNGKERVFAVKVLKKDIILQDDDVECTMTEKRVLSLARCHPYLTELYCCFQTPDRLFFVMEFVNGGDLMFHIQKSRKFDEPRARFYTAEITSALMFLHSKGIIYRDLKLDNVLLDQDGHCKLADFGMCKENIFEGAATGTFCGTPDYIAPEILQEMMYGASVDWWALGVLLYEMLSGHAPF---------EAENEDDLFESILNEEIVYASWLSTEAVDILKALLTKNPARRLGCVAAEGGECAVTSHVFFTGIDWEKLNNREMEPPFKPRIKTPEDVNNFDPDFTHEEPTLTPIDGPVIPSVNQEEFRNFSFTSPELL 684 HSP 2 Score: 61.6178 bits (148), Expect = 1.953e-9 Identity = 28/66 (42.42%), Postives = 42/66 (63.64%), Query Frame = 3
Query: 345 RRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGL-GQQGLRCGTCRLLLHKRCQQLVKHKC 539
R+GA R ++ + + GHKF + + CF+CK+ IWG+ G+QG +C C ++HKRC QLV C
Sbjct: 155 RQGAVR-RRIHQVNGHKFMSTFLRQPTFCFHCKEFIWGVFGKQGYQCQICTCVVHKRCHQLVVTVC 219
BLAST of Protein kinase C vs. Planmine SMEST
Match: SMESG000037135.1 (SMESG000037135.1) HSP 1 Score: 1261.9 bits (3264), Expect = 0.000e+0 Identity = 625/627 (99.68%), Postives = 626/627 (99.84%), Query Frame = 3
Query: 27 MHESALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENG-GIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
MHESALIKLKIIYMSEATITQINAS+TYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENG GIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRANTASGNASSNGSGGLSLLSSPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV
Sbjct: 1 MHESALIKLKIIYMSEATITQINASITYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGAGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRANTASGNASSNGSGGLSLLSSPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 627
BLAST of Protein kinase C vs. Planmine SMEST
Match: SMESG000037135.1 (SMESG000037135.1) HSP 1 Score: 1234.55 bits (3193), Expect = 0.000e+0 Identity = 612/614 (99.67%), Postives = 613/614 (99.84%), Query Frame = 3
Query: 66 MSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENG-GIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
MSEATITQINAS+TYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENG GIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRANTASGNASSNGSGGLSLLSSPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV
Sbjct: 1 MSEATITQINASITYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGAGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRANTASGNASSNGSGGLSLLSSPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 614
BLAST of Protein kinase C vs. Planmine SMEST
Match: SMESG000037135.1 (SMESG000037135.1) HSP 1 Score: 1064.68 bits (2752), Expect = 0.000e+0 Identity = 526/628 (83.76%), Postives = 542/628 (86.31%), Query Frame = 3
Query: 21 MKMHESALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
MKMHESALIKLKIIYMSEATITQINAS+TYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGT C+ L+ +C + + + E+ + N ++SN+ R +++ + PPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV
Sbjct: 1 MKMHESALIKLKIIYMSEATITQINASITYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGT--------CRLLLHKRCQQ--------------LVKHKCGEDFNLPNYQSQIKSNMAIQ-----------------RTAENGAGIE----------------NPGYYVEPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 573
BLAST of Protein kinase C vs. Planmine SMEST
Match: SMESG000037135.1 (SMESG000037135.1) HSP 1 Score: 1040.02 bits (2688), Expect = 0.000e+0 Identity = 514/613 (83.85%), Postives = 531/613 (86.62%), Query Frame = 3
Query: 66 MSEATITQINASVTYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKSNMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 1904
MSEATITQINAS+TYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRL L+ +C + + + E+ + N ++SN+ + E G +++ + + PPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV
Sbjct: 1 MSEATITQINASITYDQLRYEIHQICDLPDVSNFTMKWIDDEGDPCTITTQMELDEAIRLYETNKDAEIMMHVFPSLPTSPGMPCQGEDLKVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRL--------LLHKRCQQ--------------LVKHKCGEDFNLPNYQSQIKSNM--AIQRTAENGGIENPGYYVE--------------------------------PPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDDFQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKSKISKIDQSEFEGFEYINPLLLTTEEAV 557
BLAST of Protein kinase C vs. Planmine SMEST
Match: SMESG000042308.1 (SMESG000042308.1) HSP 1 Score: 348.206 bits (892), Expect = 4.365e-109 Identity = 196/524 (37.40%), Postives = 284/524 (54.20%), Query Frame = 3
Query: 339 VYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKCGEDFNLPNYQSQIKS----------NMAIQRTAENGGIENPGYYVESNIDYPVDGFEELGQVKDIKHDLRASDHRVAVAVRXXXXXXXXXXXXXXXXXXXXXPPVDTEGGTGDRKGKIGLGDFNLLCVVGRGSYAKVFQVEYKPTKKIYAMKVIKKEFITDSDDIEWVQTEKHVFECASNHPFLVGLHSCFQTPSRLIYVIEFVNGGDLMYHMQRKLRMPEEHAKFYAAEIALALNFLHRRAIIYRDLKLDNVLMDNDGHLKLTDYGMCKEGIEGDIKATTFCGTPNYIAPEILRNEAYGASVDWWSLGVLMFEMLAGCSPWMQPGQGIPPEENTEDYLFNLILTKPIRIPRSISPKASSILKGLLNKDPTQRLACKPSSNFDD-FQNHAFFRGLNWDDLVDKKIQPPFRPELTHDRDLTNFDPLFTDEPVMFTPDDKS-KISKIDQSEFEGFEYIN 1874
Y + +F HKF F + A C +C ++GL +QGL+C C+L +HKRC++ V CG N + IK N +RT+ + I + + + D P+ + + + + + +S ++S P + GD L DFN + V+G+GS+ KV E+K T +YA+K++KKE I +D+E TE+ + A+ HPFL LHS FQT RL +V+E+VNGGDLM+ +QR R E A FY++E+ LAL FLH+ IIYRDLKLDN+L+D +GH KL D+GMCKEG+ G +TFCGTP+YIAPEIL + YG SVDWW+LGVLM+EM+AG P+ E +TE LFN I + P S+ P + I+ L K+P +RL C H FFR ++W L +++I+PPFRP++ D +NFD FT E + TP + S +I+ + + F GF++ N
Sbjct: 226 TYSSSEAQLNRFNINVPHKFRVHTFMRPAFCDHCGSLLFGLMRQGLQCEACKLNIHKRCEKNVAPHCG--VNTKDLVEAIKKCGLNPLDLGYNPRYERTSTSANITDS---TQKSSDLPI-------HERSLSSPIPTHPDNYPITIEPVNKCLVLNSGDRSSKRVISHRPSSLQE-YGDTPKVPCLSDFNFVKVLGKGSFGKVILAEHKSTCDVYAIKILKKEVILQDEDVECTMTEQRILALAAKHPFLTALHSSFQTDDRLFFVMEYVNGGDLMFQIQRVRRFDEPRACFYSSEVTLALMFLHKHGIIYRDLKLDNILLDAEGHCKLADFGMCKEGMSGSKLTSTFCGTPDYIAPEILAEQDYGFSVDWWALGVLMYEMMAGAPPF---------EGDTEQDLFNAISYDSVSFPSSLQPASVDIVSKFLIKNPLKRLGCVAHEGGQQAIMRHPFFREIDWVLLEERRIRPPFRPKVRSRTDTSNFDKDFTSEDPVLTPIENSCEIAALGKDVFAGFDFFN 727 HSP 2 Score: 62.003 bits (149), Expect = 1.375e-9 Identity = 28/68 (41.18%), Postives = 38/68 (55.88%), Query Frame = 3
Query: 336 KVYRRGAKRWKKFYHLYGHKFSAKRFNKYAECFYCKDRIWGLGQQGLRCGTCRLLLHKRCQQLVKHKC 539
K YR GA R ++ + + GHKF F ++ C C IWGL QG +C C ++HKRC Q V +C
Sbjct: 154 KHYRAGALR-RRIHQIKGHKFQVTLFKQFTFCSLCNSFIWGLWNQGYQCQVCTCVVHKRCYQNVIVRC 220 The following BLAST results are available for this feature:
BLAST of Protein kinase C vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase C vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase C vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase C vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase C vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30008057 ID=SMED30008057|Name=Protein kinase C|organism=Schmidtea mediterranea sexual|type=transcript|length=2112bpback to top protein sequence of SMED30008057-orf-1 >SMED30008057-orf-1 ID=SMED30008057-orf-1|Name=SMED30008057-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=629bp MKMHESALIKLKIIYMSEATITQINASVTYDQLRYEIHQICDLPDVSNFTback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
