HECT domain-containing protein

Overview
NameHECT domain-containing protein
Smed IDSMED30008012
Length (bp)3801
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of HECT domain-containing protein (SMED30008012) t-SNE clustered cells

Violin plots show distribution of expression levels for HECT domain-containing protein (SMED30008012) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of HECT domain-containing protein (SMED30008012) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for HECT domain-containing protein (SMED30008012) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30008012

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
cephalic gangliaSMED30008012SMESG000048038.1 SMED30008012smed_20140614PMID:25956527
Henderson et al., 2015		whole organism asexual adult colorimetric in situ hybridization evidence
ventral nerve cordSMED30008012SMESG000048038.1 SMED30008012smed_20140614PMID:25956527
Henderson et al., 2015		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymal cellSMED30008012SMESG000048038.1 SMED30008012smed_20140614PMID:25956527
Henderson et al., 2015		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Human
Match: UBE3B (ubiquitin protein ligase E3B [Source:HGNC Symbol;Acc:HGNC:13478])

HSP 1 Score: 694.115 bits (1790), Expect = 0.000e+0
Identity = 413/1109 (37.24%), Postives = 647/1109 (58.34%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXX-XXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+T  ++    F+++ ++ RE R ++  R+++A++IQ + R F+ R  L + IR E       ++ +S K   + + K+ R    L + F+I  D + +E LCR +L+S+D+       Y+S+   KD  + WI+    IL+  CD L  ++P +  D R + + LT+++     S WKI+     S L   ++ I   +   + +      ++ LL +G+ R    LS+ +L    +L LR     + ++  + PF+I+I+SVPALV H+  +  E   ++    +  K I+ L  D      +   L   ++LC++ N++ LG L   VL      F ++L+  L    + +++  S+ +H+H + GW   S+D  +  SM  +  QL+ LW   +IR  F ++  + +L+      +  ++ +N   +  + K        +F K             +   S     + ++C+LY  + ++L+QIR  IL G++ L DL  ++W  I   G        ++  ++       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   VE AK  G+ L+       LF S +  LMVL+ER+ R  FT +  WL    KPS    +L +++  A+ +L+Y+PH+I HK RV+LF   +  +K  LGL+  +     SP    I++RR RM+EDGY+QL +++    K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS D RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD++DL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT A   GF SII+ +W  MFS PE+ +LI GD   ID++DLK++  Y GGFH  HRVI+WLWDIL ++F+ +E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +K+    RLP+++TCFNLLKLPNY  KS LREKLRY I+   GFEL
Sbjct:    1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARK---LLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGES-LRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLR-DQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASPQNVLPVKSLLK-------RAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGI---------------VENAK--GETLE-------LFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETS---SASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Human
Match: UBE3B (ubiquitin protein ligase E3B [Source:HGNC Symbol;Acc:HGNC:13478])

HSP 1 Score: 694.115 bits (1790), Expect = 0.000e+0
Identity = 413/1109 (37.24%), Postives = 647/1109 (58.34%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXX-XXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+T  ++    F+++ ++ RE R ++  R+++A++IQ + R F+ R  L + IR E       ++ +S K   + + K+ R    L + F+I  D + +E LCR +L+S+D+       Y+S+   KD  + WI+    IL+  CD L  ++P +  D R + + LT+++     S WKI+     S L   ++ I   +   + +      ++ LL +G+ R    LS+ +L    +L LR     + ++  + PF+I+I+SVPALV H+  +  E   ++    +  K I+ L  D      +   L   ++LC++ N++ LG L   VL      F ++L+  L    + +++  S+ +H+H + GW   S+D  +  SM  +  QL+ LW   +IR  F ++  + +L+      +  ++ +N   +  + K        +F K             +   S     + ++C+LY  + ++L+QIR  IL G++ L DL  ++W  I   G        ++  ++       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   VE AK  G+ L+       LF S +  LMVL+ER+ R  FT +  WL    KPS    +L +++  A+ +L+Y+PH+I HK RV+LF   +  +K  LGL+  +     SP    I++RR RM+EDGY+QL +++    K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS D RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD++DL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT A   GF SII+ +W  MFS PE+ +LI GD   ID++DLK++  Y GGFH  HRVI+WLWDIL ++F+ +E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +K+    RLP+++TCFNLLKLPNY  KS LREKLRY I+   GFEL
Sbjct:    1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARK---LLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGES-LRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLR-DQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASPQNVLPVKSLLK-------RAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGI---------------VENAK--GETLE-------LFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETS---SASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Human
Match: UBE3B (ubiquitin protein ligase E3B [Source:HGNC Symbol;Acc:HGNC:13478])

HSP 1 Score: 442.58 bits (1137), Expect = 1.645e-137
Identity = 300/920 (32.61%), Postives = 493/920 (53.59%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXX-XXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKL---HFSYKASTTN------EXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITV 2870
            M+T  ++    F+++ ++ RE R ++  R+++A++IQ + R F+ R  L + IR E       ++ +S K   + + K+ R    L + F+I  D + +E LCR +L+S+D+       Y+S+   KD  + WI+    IL+  CD L  ++P +  D R + + LT+++     S WKI+     S L   ++ I   +   + +      ++ LL +G+ R    LS+ +L    +L LR     + ++  + PF+I+I+SVPALV H+  +  E   ++    +  K I+ L  D      +   L   ++LC++ N++ LG L   VL      F ++L+  L    + +++  S+ +H+H + GW   S+D  +  SM  +  QL+ LW   +IR  F ++  + +L+                   P    P  P +    K L    F   AS  N       +   S     + ++C+LY  + ++L+QIR  IL G++ L DL  ++W  I   G        ++  ++       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   VE AK  G+ L+       LF S +  LMVL+ER+ R  FT +  WL    KPS    +L +++  A+ +L+Y+PH+I HK RV+LF   +  +K  LGL+  +     SP    I++RR RM+EDGY+QL +++    K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS D RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD++DL LT SYDED +G++  H+L PGG+ I V
Sbjct:    1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARK---LLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGES-LRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLR-DQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQE----------------PAHAQPASPQNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGI---------------VENAK--GETLE-------LFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETS---SASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPV 871
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Human
Match: UBE3C (ubiquitin protein ligase E3C [Source:HGNC Symbol;Acc:HGNC:16803])

HSP 1 Score: 287.345 bits (734), Expect = 7.045e-80
Identity = 168/436 (38.53%), Postives = 253/436 (58.03%), Query Frame = 3 
Query: 2166 LLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPI--GAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLL-FQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            +L  +P ++  +ERV +F   I ADK  +          D P   G  +++RR  + ED YD+L   N  D KK+IRV  +N  G+DE GID  G+F+EFL E LK+  NP+   F TT++  LYP+P + +   +     + +LGRM+ KA+YE +L+E PFA FFL+++L    ++    I  L +LD ++YK+L ++K Y+ DV +L L F+   + LG+ +  +L+ GG+ I VT+  +I+Y+H+VA +R+ +QIR    AF+ G  +++  +W  MF   E+  LI G    I ++DLK    YSGG+ A H VI   W +++  F++ EK   LKFVTSCS+PPLLGF  L P+F   C+H+                         +D++RLP+A+TC NLLKLP +  ++ LR KL Y I   AGFEL
Sbjct:  685 VLTELPFVVPFEERVKIFQRLIYADKQEV--------QGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLG---TSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEG-FTDEEKRKLLKFVTSCSRPPLLGFKELYPAF---CIHNGG-----------------------SDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFEL 1082
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Human
Match: UBE3B (ubiquitin protein ligase E3B [Source:HGNC Symbol;Acc:HGNC:13478])

HSP 1 Score: 257.299 bits (656), Expect = 4.712e-72
Identity = 201/744 (27.02%), Postives = 357/744 (47.98%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXX-XXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKL---HFSYKASTTN------EXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYD 2345
            M+T  ++    F+++ ++ RE R ++  R+++A++IQ + R F+ R  L + IR E       ++ +S K   + + K+ R    L + F+I  D + +E LCR +L+S+D+       Y+S+   KD  + WI+    IL+  CD L  ++P +  D R + + LT+++     S WKI+     S L   ++ I   +   + +      ++ LL +G+ R    LS+ +L    +L LR     + ++  + PF+I+I+SVPALV H+  +  E   ++    +  K I+ L  D      +   L   ++LC++ N++ LG L   VL      F ++L+  L    + +++  S+ +H+H + GW   S+D  +  SM  +  QL+ LW   +IR  F ++  + +L+                   P    P  P +    K L    F   AS  N       +   S     + ++C+LY  + ++L+QIR  IL G++ L DL  ++W  I   G        ++  ++       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   VE AK  G+ L+       LF S +  LMVL+ER+ R  FT +  WL    KPS    +L +++  A+ +L+Y+PH+I HK RV+LF   +  +K  LGL+  +     SP    I++RR RM+E  ++
Sbjct:    1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARK---LLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGES-LRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLR-DQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQE----------------PAHAQPASPQNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGI---------------VENAK--GETLE-------LFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETS---SASPHVTHITIRRSRMLESLFE 696
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Celegans
Match: oxi-1 (OXidative stress Induced [Source:UniProtKB/TrEMBL;Acc:Q9XXE6])

HSP 1 Score: 504.597 bits (1298), Expect = 6.260e-159
Identity = 366/1097 (33.36%), Postives = 581/1097 (52.96%), Query Frame = 3 
Query:  252 IQRYYRGFIIRKNLVKKIRDEFRQCL--DINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTET--YLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILH-LHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLS---SLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVSLTD-LPARMWRLIQ--------------NSGSVKQWANIIKDSDS-GWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFT-ND-RFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            ++ Y  G++ RK    KI+  FR     D N+ +      + V +++  +  +  N + N D +   ++CR L+ SIDS     S+++  L KD+I E   L   I       L +I      + +Q   ++  +I   + S W +V   N   +   L+ +   + S   +    + M   L   V      ++  ++N   +++ +  +    TE       F++ +L+ PAL+ H++    E+ +        TKI    LH    N  +I + +     + ++AN++    +    L +   E+   +    S   +L      T +S  ++H +FG   + +D+  + ++ ++  QLK+LWSS+++R +F  + +     K    S     K +K +     KL         W+KL  S  +++++ +      P  I  VC +Y    +++  ++ +I++G+   D L  ++W  ++              NS + +QW  +     S    S PH +  L +FV  A  +  ILD+ E+FEKE  F+  EL  +  + N      + S               +D   A  +G           LF S ++LL VL+ER+ R  F  ND +FWL S  KPS    + +K+      +++ + H++  K+R++LF  +++ DK  +       + +D  +   I+V+R R++EDG++ L K+     K  IRV+F+NE G+DE GID DGVFKEFLE TLK + +P LNLF TTS   LYPSP S L++ +HL LF ++GRM+ KA+YE I+++   A   L  VL    S+     DEL+ LD +LY+SLT+VK Y+G+++DL LTFS DED +GKI T DL P GR I+VTN+ KI YVH +A  R+F++ ++Q +AF  G  SI+Q  W  +F+  ++  LI G    ID+ DLK+NV+Y GGFH  HR+I WLWDIL+N+F+  E+ LFLKFVTSCS+PP+LGF+YLEP FSIRCV  SD DQ+  DT+GS+++    + +K     RLP+A+TCFNLLKLPNY  KS L EKLRY I++G GFEL
Sbjct:   31 LEPYLIGYLTRKKFHGKIKT-FRPTFFNDFNDLEKSNKTLLPVAQMLVKVPRVIENSRENKDIQMLCNICRHLIISIDSPSKEISFVAAFLNKDTIKEATSLITSIFSQIPQILCSINGERAAELKQWQCLIHFVIVFSSSSNWLLVR--NAPQVQTVLNGLCVKMMSLFYEPKGYEQMATSLFVSVNGHKPLINVETVNAQFSILCKPLK----TENPELFSIFVLKVLTCPALLVHLNAQHVELLKT-------TKIFEKTLHWLRANAEEIETGMDVRLLINLLANLVHFAYINDKTLESKLYEWTWAVGVSLSRCTELTVKHGGTKTSLHYWHPVFGHYLLPIDKRTEGALRNVLFQLKMLWSSRVVRCLFGNIMEN---TKTASFSVTDGQKNSKDISAAFSKL---------WRKLGGSTDSASSSSKSESEPPPTLIAIVCQVYMTALNTMVHMKGEIISGLCRDDQLLKQLWTYLREWGEKAGGTSGSIFNSSNAEQWGPVSASLQSLKRPSSPHTA-TLRLFVDCAAAIISILDEEEIFEKETPFSNKELESICKYVNIFCFRSIWSGA-------------VDETSANTTG-----------LFHSMHSLLTVLYERDSRRSFAANDSKFWLISEVKPSSLTIEYEKKSGKGVLMMRKMAHLVPIKDRMLLFRRQVQDDKNRVAT-----SLNDPQMQTWITVQRNRIIEDGFNHLSKLTIPALKSTIRVKFVNEQGLDEAGIDQDGVFKEFLELTLKKVFDPQLNLFSTTSTGVLYPSPTSSLHD-DHLALFTFVGRMLGKAVYEGIVVDVQLAPVLLAAVL---GSHRLCAFDELSQLDPELYRSLTFVKRYEGEMADLSLTFSVDEDFMGKISTVDLVPSGRTISVTNENKIDYVHRMAHHRVFRRTQEQCKAFVTGMQSILQPTWLSLFAPNDLQCLISGVNSDIDLADLKRNVQYFGGFHGNHRLIKWLWDILENKFTSEERKLFLKFVTSCSRPPVLGFSYLEPPFSIRCVEVSD-DQDQGDTLGSVVRGFLAL-RKGTAATRLPTASTCFNLLKLPNYNKKSLLLEKLRYAIHAGTGFEL 1065
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BLAST of HECT domain-containing protein vs. Ensembl Celegans
Match: etc-1 (E3 ubiquitin-protein ligase etc-1 [Source:UniProtKB/Swiss-Prot;Acc:O17736])

HSP 1 Score: 192.586 bits (488), Expect = 1.258e-49
Identity = 135/447 (30.20%), Postives = 226/447 (50.56%), Query Frame = 3 
Query: 2166 LLKYVPHIIAHKERVVLFHEKIKADK-----ASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYD----QLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSG-LYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDG-DVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVW---LWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            ++K++P I+   +RV LF   +  DK     ++ G+    +N      G  ++VRR ++  D ++    ++     +D K  +RV+ +N  GM+E GID  G+F+EFL E LKT  N     F  T    LYP+P +  L   + L  FQ++GRM+ K IYE  L E  FA FF+ Q+   +++     +  + + D  ++K L  ++  +  ++ +L+L FS     +G +   +L+P G    VT +    YV +   + + Q+I     A + G   II  +W  MF+  E+  +I G   +    +L++       F AG + I +    WD++ ++ S ++K   LKFVT CS+ P+ GF  ++P   +  + SSD++                          LP++ATC N+L++P Y +++ L EKLRY INSGAGFEL
Sbjct:  593 VMKHIPFIVPFMDRVKLFTRLLNQDKEKHYTSTFGM---GFN------GPSVTVRRDQVYMDAFETFAPKMQGDKVNDLKSMVRVKMVNWAGMNESGIDGGGIFREFLSELLKTAFNVERGFFTFTESKLLYPNPTAPFLLGVDCLAHFQFIGRMIGKLIYERQLQEVRFAEFFIAQIFETDKNKDVD-LQHMKSFDPIIFKHLKALQKMNNRELDELQLDFSVVTSDMGLVRNVNLKPNGSKFRVTVENVHEYVRLYVNYHLKQRIASMVDAVRKGISEIISIEWMRMFAPHELQIMIAGYEEVFTAKELRKFCELR--FAAGTQDINYEEMFWDVI-DKLSNDDKKALLKFVTGCSRAPVDGFKSIQPRMGVLVIPSSDDE--------------------------LPTSATCMNMLRIPKYSNRTKLEEKLRYAINSGAGFEL 1000
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Celegans
Match: wwp-1 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:V6CJJ8])

HSP 1 Score: 161.384 bits (407), Expect = 1.107e-41
Identity = 111/392 (28.32%), Postives = 193/392 (49.23%), Query Frame = 3 
Query: 2289 PIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNR--LYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            P    I+V R  + ED + ++M+ N  D ++++ ++F       E G+D  GV +E+       +LNP   LF    +N   L  +P S     +HL  F+Y+GR +A A++    I + F   F  ++L+K+       + ++  +D ++Y SL ++K  + D  D+EL F  D + LG+++T++L+ GG  I VT + K+ Y+ ++  +R  + +  QT+AF  GF S+   +W   F   E+  L+CG    +DVDD ++N  Y   +    + + W W  +++   + +++  L+FVT   + P+ GF+ L                     +GS    +F + +   +   LP + TCFN L LP Y S   L EKL   I    GF
Sbjct:  147 PNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQF-----RGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPAS-FVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKK-----IVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQD-VDVDDWQRNTVYR-HYAPQSKQVTWFWQWVRS-LDQEKRARLLQFVTGTCRVPVGGFSEL---------------------MGSTGPQLFCIERVGKE-NWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGF 502
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Celegans
Match: wwp-1 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:V6CJJ8])

HSP 1 Score: 161.384 bits (407), Expect = 1.107e-41
Identity = 111/392 (28.32%), Postives = 193/392 (49.23%), Query Frame = 3 
Query: 2289 PIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNR--LYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            P    I+V R  + ED + ++M+ N  D ++++ ++F       E G+D  GV +E+       +LNP   LF    +N   L  +P S     +HL  F+Y+GR +A A++    I + F   F  ++L+K+       + ++  +D ++Y SL ++K  + D  D+EL F  D + LG+++T++L+ GG  I VT + K+ Y+ ++  +R  + +  QT+AF  GF S+   +W   F   E+  L+CG    +DVDD ++N  Y   +    + + W W  +++   + +++  L+FVT   + P+ GF+ L                     +GS    +F + +   +   LP + TCFN L LP Y S   L EKL   I    GF
Sbjct:  147 PNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQF-----RGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPAS-FVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKK-----IVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQD-VDVDDWQRNTVYR-HYAPQSKQVTWFWQWVRS-LDQEKRARLLQFVTGTCRVPVGGFSEL---------------------MGSTGPQLFCIERVGKE-NWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGF 502
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Celegans
Match: wwp-1 (E3 ubiquitin-protein ligase [Source:UniProtKB/TrEMBL;Acc:V6CJJ8])

HSP 1 Score: 161.384 bits (407), Expect = 1.293e-41
Identity = 111/392 (28.32%), Postives = 193/392 (49.23%), Query Frame = 3 
Query: 2289 PIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNR--LYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            P    I+V R  + ED + ++M+ N  D ++++ ++F       E G+D  GV +E+       +LNP   LF    +N   L  +P S     +HL  F+Y+GR +A A++    I + F   F  ++L+K+       + ++  +D ++Y SL ++K  + D  D+EL F  D + LG+++T++L+ GG  I VT + K+ Y+ ++  +R  + +  QT+AF  GF S+   +W   F   E+  L+CG    +DVDD ++N  Y   +    + + W W  +++   + +++  L+FVT   + P+ GF+ L                     +GS    +F + +   +   LP + TCFN L LP Y S   L EKL   I    GF
Sbjct:  149 PNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQF-----RGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPAS-FVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKK-----IVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQD-VDVDDWQRNTVYR-HYAPQSKQVTWFWQWVRS-LDQEKRARLLQFVTGTCRVPVGGFSEL---------------------MGSTGPQLFCIERVGKE-NWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGF 504
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Fly
Match: CG5087 (gene:FBgn0035953 transcript:FBtr0333908)

HSP 1 Score: 627.091 bits (1616), Expect = 0.000e+0
Identity = 398/1114 (35.73%), Postives = 622/1114 (55.83%), Query Frame = 3 
Query:  162 KSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNY------EHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSS---SHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVSLTD-LPARMWRLIQNSG---SVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            +++  SFLE+TK  RE R LE  R+++AI++Q   +G+  R+   K+I  +F      N+DD      +  + +   ++  RY  +I  DK +       E +CR ++ +++S  +  SY ++ L K+  + WI     +L N    L  ++P    D   + + L  ++       W I+       L   + KI   +   +++ +  K M+ +L++G  R+ + +  ++L  I+TL LR   D   +   L  F+  ILSVPAL+ H+   V +  +      L  K  L +  D +   +  + +P + SL  + NI++L    +D           +L+     L + I  T+++    + +H + GW     +     ++  ++ Q  +LW  + I+ +  +L  Q  L+  R +           L+     L R  T G     +  S K S    +   S   + +  +C +Y+   ++LSQ++ DIL G+  +D +   +W LI + G    +K++  ++K   +    +P  + L+ +F     +   ILD+HE++ ++  F + + V +  F N++             L KLI+   +  +            +    +F S + L++ L+ R+ R PFT  + WL    KPS F+ DL+K K  A  LL  +PHII H++RV LF + ++ +KA +GL         SP  A+I + R R+VEDGY QL    T   K  IRVRFIN+ G+ E GID DGVFKEFLEET+K + +PSLNLF TTSD RLYPSP+S + + NHL LF+++GRM+ KA+YE I+++ PFA+FFL+Q+L + Q  +YS +DEL +LD +LY+SLT++KHY  DVSDL LTFS D+D +GKI T  L PGG+   V +  K+ Y+H +A F M  QIR+QT AF  GF SI+  +W  +FS PE+ +LI GDT  +D+ DL+++  Y GGFH  H+V+ WLWDIL  +F+E E+ LFLKFVTSCSKPPLLGFA+LEP FSIRCV  SD D++  DT+GS+++  F + +KK+ + RLP+++TCFNLLKLPNY+ KSTLR+KLRY ++S  GFEL
Sbjct:    4 QNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENHDDKDAELELVASNVYPVLR--RYLTQIRLDKSDVRARERLERICRYIIKAMESENTKLSYAALCLFKERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKA-LSISGDVQWFEEFGTSMPGTKSLAFLGNIVNL--FNIDGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRR--ALERSSTRGVNLMGVA-SSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSETN--LQKPQTAMLM-LFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNI-------------LYKLINDNLLGAK-----------NIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACA---SPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPISYV-QDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSD-DEDTGDTIGSVIRGFFAI-RKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1076
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Fly
Match: CG5087 (gene:FBgn0035953 transcript:FBtr0076520)

HSP 1 Score: 627.091 bits (1616), Expect = 0.000e+0
Identity = 397/1114 (35.64%), Postives = 621/1114 (55.75%), Query Frame = 3 
Query:  162 KSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNY------EHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSS---SHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVSLTD-LPARMWRLIQNSG---SVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            +++  SFLE+TK  RE R LE  R+++AI++Q   +G+  R+   K+I  +F      N+DD      +  + +   ++  RY  +I  DK +       E +CR ++ +++S  +  SY ++ L K+  + WI     +L N    L  ++P    D   + + L  ++       W I+       L   + KI   +   +++ +  K M+ +L++G  R+ + +  ++L  I+TL LR   D   +   L  F+  ILSVPAL+ H+   V +  +      L  K  L +  D +   +  + +P + SL  + NI++L    +D           +L+     L + I  T+++    + +H + GW     +     ++  ++ Q  +LW  + I+ +  +L  Q  L+  R +           L+     L R  T G     +  S K S    +   S   + +  +C +Y+   ++LSQ++ DIL G+  +D +   +W LI + G    +K++  ++K   +    +P  + L+ +F     +   ILD+HE++ ++  F + + V +  F N++  +++         N L   + I                    +F S + L++ L+ R+ R PFT  + WL    KPS F+ DL+K K  A  LL  +PHII H++RV LF + ++ +KA +GL         SP  A+I + R R+VEDGY QL    T   K  IRVRFIN+ G+ E GID DGVFKEFLEET+K + +PSLNLF TTSD RLYPSP+S + + NHL LF+++GRM+ KA+YE I+++ PFA+FFL+Q+L + Q  +YS +DEL +LD +LY+SLT++KHY  DVSDL LTFS D+D +GKI T  L PGG+   V +  K+ Y+H +A F M  QIR+QT AF  GF SI+  +W  +FS PE+ +LI GDT  +D+ DL+++  Y GGFH  H+V+ WLWDIL  +F+E E+ LFLKFVTSCSKPPLLGFA+LEP FSIRCV  SD D++  DT+GS+++  F + +KK+ + RLP+++TCFNLLKLPNY+ KSTLR+KLRY ++S  GFEL
Sbjct:    4 QNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENHDDKDAELELVASNVYPVLR--RYLTQIRLDKSDVRARERLERICRYIIKAMESENTKLSYAALCLFKERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKA-LSISGDVQWFEEFGTSMPGTKSLAFLGNIVNL--FNIDGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRR--ALERSSTRGVNLMGVA-SSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGMKEYLELLKSETN--LQKPQTAMLM-LFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLIND-------NLLAGAKNI----------------VQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACA---SPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQRLYPSPISYV-QDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSD-DEDTGDTIGSVIRGFFAI-RKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Fly
Match: CG3356 (gene:FBgn0034989 transcript:FBtr0072262)

HSP 1 Score: 286.574 bits (732), Expect = 9.585e-80
Identity = 167/438 (38.13%), Postives = 257/438 (58.68%), Query Frame = 3 
Query: 2166 LLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSP-LSGLYE--QNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFID--ELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            +L+ +P ++   +RV +    + A K  +    + +    S    +I+VRR  + ED YD+L   N  D + K R++F++ LG+DE GID  GVF+EFL E +KT  +P+   F  T+DN+LYP+P ++ L+E  + H   + ++GR++ K+IYE +L+E P A FFLT++  K     YS +D  +L +LD +LY++L Y+K Y GDVS+L L F+     LG+ +  +L+P G+ I VTN  +I Y+ ++A +++  QIR    AF+ G  +++  +W  MFS  E+  LI G    ID++DLK++  Y G F   H  IV  W++L+  F + ++   LKFVTSCS+PPLLGF  L+P F I                           +   D++RLP+A+TC NLLKLP +++   +REKL Y I SGAGFEL
Sbjct:  723 ILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPS---VLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFEDYEKH---YYFIGRILGKSIYENLLVELPLAEFFLTKLAGK-----YSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEG-FDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFI---------------------------QNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFEL 1121
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Fly
Match: Nedd4 (gene:FBgn0259174 transcript:FBtr0299642)

HSP 1 Score: 170.629 bits (431), Expect = 4.168e-43
Identity = 128/388 (32.99%), Postives = 190/388 (48.97%), Query Frame = 3 
Query: 2304 ISVRRQRMVEDGYDQLMKVN-TDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            I +RR  ++ED Y  +  V  TD  K K+ V F       E G+D  G+ +E+     K + NP   LF  ++ DN  L  +  SGL  + HL  F+++GR+   A+Y   L++A F   F   +L K        + ++ ++D + Y SL ++K  D  +  LELTF  DED  G+   H+L+PGG  I VTN+ K  Y+ +V  +R   ++++Q  +F  GF SII  +   +F   E+  L+CG    IDV D ++N  Y G +H  H +I W W  + + FS   +S  L+FVT  S+ P+ GF  L                      GS    +FT+ +K       P A TCFN L LP YE    L++KL   I    GF
Sbjct:  438 IRIRRTSILEDSYRIISSVTKTDLLKTKLWVEF-----EGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPID-----LKDMESVDTEYYNSLMWIKENDPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQN-IDVKDWRENTLYKGDYHMNHIIIQWFWRAVLS-FSNEMRSRLLQFVTGTSRVPMNGFKEL---------------------YGSNGPQMFTI-EKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 789
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Fly
Match: Nedd4 (gene:FBgn0259174 transcript:FBtr0300520)

HSP 1 Score: 170.629 bits (431), Expect = 6.048e-43
Identity = 128/388 (32.99%), Postives = 190/388 (48.97%), Query Frame = 3 
Query: 2304 ISVRRQRMVEDGYDQLMKVN-TDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            I +RR  ++ED Y  +  V  TD  K K+ V F       E G+D  G+ +E+     K + NP   LF  ++ DN  L  +  SGL  + HL  F+++GR+   A+Y   L++A F   F   +L K        + ++ ++D + Y SL ++K  D  +  LELTF  DED  G+   H+L+PGG  I VTN+ K  Y+ +V  +R   ++++Q  +F  GF SII  +   +F   E+  L+CG    IDV D ++N  Y G +H  H +I W W  + + FS   +S  L+FVT  S+ P+ GF  L                      GS    +FT+ +K       P A TCFN L LP YE    L++KL   I    GF
Sbjct:  479 IRIRRTSILEDSYRIISSVTKTDLLKTKLWVEF-----EGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPID-----LKDMESVDTEYYNSLMWIKENDPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQN-IDVKDWRENTLYKGDYHMNHIIIQWFWRAVLS-FSNEMRSRLLQFVTGTSRVPMNGFKEL---------------------YGSNGPQMFTI-EKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 830
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Zebrafish
Match: ube3b (ubiquitin protein ligase E3B [Source:ZFIN;Acc:ZDB-GENE-060526-231])

HSP 1 Score: 684.485 bits (1765), Expect = 0.000e+0
Identity = 420/1116 (37.63%), Postives = 640/1116 (57.35%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKK-NYEHLCRQLL-TXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTN------EXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+T  ++    FL+K +  RE R+    ++++A  IQ   R F+ R  L K+IR E    + +++    K   + + K+ R +      F ++ D K  +E LCR +L +    ++    Y+S+ L KD  + W++    +L+ +C+ L  ++P +  D + + + LT++I     S WKI+     + L   L++I + +   + +      ++ LL  G+ R    LS+ +L  I TL LR       ++  L  F+++++SVPA + H++ +  +    I    L  K +L L S  +  + I   L  S++LC++ N+I LG   + VL      F   L+ +L    + +++  S+ +H+H + GW   ++D  +  SM  +  QL+ LW   +I ++F ++  + +  ++            +           LP    F  K  F   AS  N       +   S     + S+C+LY    ++L+QIR  IL G++ L +L  ++W  I   G        ++  ++       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    ++V                   +E AK    DL         F S +  LMVL+ER+ R  FT +  WL    KPS    +L+K K  A+ LL+Y+PH+I HK RV+LF   +  +K +LGL+  +     SP    I++RR RM+EDGYDQL ++  +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + NP+LNLF TTS N RLYPSP S ++E NHL LF+++G+M+ KA+YE I+++ PFA+FFL+QVL    S  YS IDEL +LD + YK+LT +K YDGDVSDL LT SYDE+ +G++  H+L PGG+ + VTN+ KISY+H++A FRM  QI++QT AF  GF SII  +W  MFS PE+ +LI GD   ID+DDLK++  Y GGFH+ HRVI+WLWDIL ++F+ +E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ KK+    RLP+++TCFNLLKLPNY  KS LR+KLRY I+   GFEL
Sbjct:    1 MFTATQTSKTQFLDKARVAREERKGHKEKERAATQIQALVRRFLCRCRLQKEIRKEVDDFIAVSDAGPTKRNALSIFKIARKLL-----FILSKDDKLRFEKLCRIILNSMDVENEPKVWYVSLALSKDLTILWLKQIKDVLWVSCEFLKKLKPDILQDNKLVTLYLTMLITFTDTSTWKIIRGKGEA-LKPALNRICENIMGHLNQKGFYSVLQILLTNGLARSRPSLSKGTLTAIFTLSLRPVIAAHFSDNLLRSFLLHVMSVPAFISHLNTLTPDCMITIQTHDLFRKFVLFL-SREEQCLDICVCLEGSHTLCLLGNLIQLGYFNVKVLEQEAGHFVKDLTDMLSYCQRYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLVTKQLQCLWGVPVICTLFCDVLSKKLETQDPTPPPAPQPSSLQN---------NLPVKNLF--KRAFQKSASVRNILKPVGGKRVDSAEVQKVCSICVLYQTALTTLTQIRLQILTGLTYLDELLPKLWAFICELGPQGGLRLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKMEELVTISSFLNTFVYKMVWDGI---------------LENAKGEKLDL---------FHSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSLLFQELEKGKKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKETLGLVETS---SASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPTSSIHE-NHLQLFEFVGKMLGKAMYEGIVVDVPFASFFLSQVLGHHHSTFYSSIDELPSLDSEFYKNLTSIKRYDGDVSDLGLTLSYDEEVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTAAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYGGFHSSHRVILWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTIRKKEPG-GRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFEL 1068
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Zebrafish
Match: ube3c (ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-GENE-040426-1211])

HSP 1 Score: 300.056 bits (767), Expect = 2.024e-84
Identity = 190/522 (36.40%), Postives = 285/522 (54.60%), Query Frame = 3 
Query: 2016 LFSSCYNLLMVLFERNIRHPFTNDRFWLS-----------------SSH----------KPSQFMADL---------KKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPI--GAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSG-LYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            LF    NL+ +L  R+IR PF     WLS                 + H           P Q   D+          +E+ +A  +L  +P ++  +ERV +F + I ADK  +          + P   G  +++RR  + ED YD+L   N  D KK+IRV  +N  G+DE GID  G+F+EFL E LK+  NP+   F TT++  LYPSP +  L  ++    + +LGR++ KA+YE +L+E PFA+FFL+++L    ++    I  L +LD ++Y++L ++K Y+GDV DL L F+   + LG+ +  +L+PGG+ I VT   +I+Y+H+VA +R+ +QIR    AF+ G  +++  +W  MF   E+  L+ G    I ++DLK+   YSGG+ A H VI   WD++++ FS+ EK   LKFVTSCS+PPLLGF  L P+F   C+H+                          D++RLP+A+TC NLLKLP +     +R KL Y I S AGFEL
Sbjct:  599 LFKVITNLVKMLKARDIRRPFCPSGHWLSDEVNIRADKVTQLYVPSARHMWRTRRMGRIGPLQSTLDVGLEPPPLSVSEERHLA--ILTELPFVVPFEERVKIFQKLIYADKREV--------QGEGPFLDGVNVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPSPTAEMLVGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLL---GTSADVDIHHLASLDPEMYRNLLFLKSYEGDVEDLGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLVSGAHVPICLEDLKRFTNYSGGYSATHPVIKIFWDVVES-FSDEEKRKLLKFVTSCSRPPLLGFKELYPAF---CIHNGG-----------------------TDLERLPTASTCMNLLKLPEFCDPQLMRNKLLYAIESSAGFEL 1080
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Zebrafish
Match: ube3c (ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-GENE-040426-1211])

HSP 1 Score: 192.2 bits (487), Expect = 2.024e-49
Identity = 127/373 (34.05%), Postives = 202/373 (54.16%), Query Frame = 3 
Query: 2016 LFSSCYNLLMVLFERNIRHPFTNDRFWLS-----------------SSH----------KPSQFMADL---------KKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPI--GAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSG-LYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEM 3017
            LF    NL+ +L  R+IR PF     WLS                 + H           P Q   D+          +E+ +A  +L  +P ++  +ERV +F + I ADK  +          + P   G  +++RR  + ED YD+L   N  D KK+IRV  +N  G+DE GID  G+F+EFL E LK+  NP+   F TT++  LYPSP +  L  ++    + +LGR++ KA+YE +L+E PFA+FFL+++L    ++    I  L +LD ++Y++L ++K Y+GDV DL L F+   + LG+ +  +L+PGG+ I VT   +I+Y+H+VA +R+ +QIR    AF+ G  +++  +W  MF   E+
Sbjct:  599 LFKVITNLVKMLKARDIRRPFCPSGHWLSDEVNIRADKVTQLYVPSARHMWRTRRMGRIGPLQSTLDVGLEPPPLSVSEERHLA--ILTELPFVVPFEERVKIFQKLIYADKREV--------QGEGPFLDGVNVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPSPTAEMLVGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLL---GTSADVDIHHLASLDPEMYRNLLFLKSYEGDVEDLGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEI 958
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Zebrafish
Match: hace1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:572430])

HSP 1 Score: 177.178 bits (448), Expect = 8.438e-45
Identity = 135/474 (28.48%), Postives = 224/474 (47.26%), Query Frame = 3 
Query: 2037 LLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDL--ELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGA 3452
            +L     RN +  F +  F L      S+FM  +K + F               K+R   F+E + A +    ++ R  N +D     ++ V R  +     + + K + +  K+ I VRF  E GM +      GV +E+ +     ++NP   LF  ++D   +    +     +HL  F++ G+++  A+Y   L+     N + T+  +K    +     +++++D +  K+L ++   D D+SDL  ELTFS + D  G +E   L+PGG  I VT D K  YV +V   RM + I+ Q  AF  GF++ I      +F   E L+L+      IDV D K+N  Y+ G+     VI W W++++N  ++ E+ L L+FVT  S+ P  GFA+L                      GS L+  FT++        LP+++TC N+LKLP Y SK  LR++L   ++ G+
Sbjct:  482 VLKCFVTRNPKIIFNHFHFLLECPELMSRFMHIIKGQPF---------------KDRCEWFYEHLLAGQPDSDMVHRPVNEND-----ILLVHRDSLFRSSCEVVSKSSNEKLKQGIAVRFHGEEGMGQ------GVVREWFDILSNEIINPDYALFTQSADGTTFQPNSNSSVNPDHLNYFRFAGQILGLALYHRQLV-----NIYFTRSFYKHILGIPVSYQDVSSIDPEYAKNLQWI--LDNDISDLGLELTFSVETDVFGTMEEVPLKPGGTTIQVTQDNKEEYVQLVTELRMTRAIQPQINAFLQGFHTFIPPSLIQLFDEYE-LELLLSGMPEIDVMDWKRNTEYTSGYDLQEPVIQWFWEVVEN-LTQEERVLLLQFVTGSSRVPHGGFAFL--------------------MGGSGLQK-FTVAAVPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLLVALHCGS 899
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Zebrafish
Match: nedd4l (NEDD4 like E3 ubiquitin protein ligase [Source:ZFIN;Acc:ZDB-GENE-051118-2])

HSP 1 Score: 168.318 bits (425), Expect = 8.007e-42
Identity = 129/432 (29.86%), Postives = 207/432 (47.92%), Query Frame = 3 
Query: 2178 VPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVN-TDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLF--CTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSL-FLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFE 3461
            VP+    K++   F +K+K                D P    + + R  + E+ Y ++M +   D  K ++ + F +E      G+D  GV +E+     K + NP   LF    T +  L  +P SGL  ++HL  F+++GR+   A+Y   L++  F   F   +L K+ +     ++++ ++D + Y SL ++   + D ++L+L F  DED  G+    DL+P G  + VTND K  Y+ +V ++R   +++ Q  AF  GF  +I  D   +F   E+  L+CG  G +DV+D +Q+  Y  G+   H VI W W  +     + EK +  L+FVT  S+ P+ GFA L                      GS    +FT+ +     K LP A TCFN L LP YE+   LREKL   + +  GFE
Sbjct:  604 VPYSREFKQKYDYFRKKLKKPA-------------DIPNRFEMKLHRNNIFEESYRRIMSLKRPDSLKARLWIEFESE-----KGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLGKQIT-----LNDMESVDSEYYNSLKWI--LENDPTELDLRFCIDEDNFGQTYQVDLKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIFDENELELLMCG-LGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAML--LMDAEKRIRLLQFVTGTSRVPMNGFAEL---------------------YGSNGPQLFTIEQWGTPDK-LPRAHTCFNRLDLPMYETFEDLREKLLMAVENAQGFE 985
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Xenopus
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:780337])

HSP 1 Score: 688.337 bits (1775), Expect = 0.000e+0
Identity = 424/1113 (38.10%), Postives = 640/1113 (57.50%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLL-TXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSG----SFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSD-NRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+   +     FL+K ++ RE R+    R ++AI IQ   R F+ R  L K+IR E    L+     S K   + + ++ R +  +   F+I+ D+  +E LCR +L +  + ++    ++S+ L KD  + WI+    IL+   + L  ++P +  D + + V LT+++       WKI+     S L   ++ I   +   + +      ++ LL  G+ R    LS+ +L  + +L LR     + ++  L  F+I+I+SVPALV H+  +  +   +I  + L  K IL L  + +    +   L  S++LC++ N+I LG L   VL      F +VL+ +L    + +++  S+ +H+H + GW   ++D  +  SM  L  QL+ LW   MIR++F E+  + + +       +S +  +            LP       +F K     +       +   S     + ++C+LY    ++L+QIR  IL G++ L DL  ++W  I   G        ++   S       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  F  +  WL    KP+    +L KE+  A+ LL+Y+PH+I HK RV+LF   +  +K  LGL+  N     SP    I++RR RM+EDGYDQL +++ +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS  +RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD+SDL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT AF  GF SII+ +W  MFS PE+ +LI GD   ID+DDLK++  Y GGFH  HRVI+WLWDIL N+FS  EK++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +KK    RLP+++TCFNLLKLPNY  K  LREKLRY I+   GFEL
Sbjct:    1 MFGATQVSKAQFLDKARQAREERKGLKERDRAAIKIQALIRRFLCRCRLQKEIRQEVDDFLEGTEKGSVKANALSIFRISRKLLII---FQISQDRMRFEKLCRCILNSMENDNEPKVWFVSLALSKDLTLLWIKQIKDILWYCSEYLKQLKPDILQDSKLITVYLTMLVTFTDTLTWKILKGKGES-LRPAMNHICANIMGYLNQKGFYSVLQILLTNGLARSRPSLSKGTLTALFSLALRPVVAAQYSDNLLRSFLIHIMSVPALVSHLSTLTPDRLSVIESNGLFHKFILFLSREDQCS-DVCECLEGSHTLCLLGNLIHLGHLTEKVLEEEMFHFVSVLTQMLSYCQKYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLLTKQLQHLWGVHMIRNLFREVLSKKLAENQDVSVPVSQSSSSS-------PQNNLPMKNLFKRAFQKSASVRHILKPIGGKKVDSPEVQKVCNICVLYQMALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLSSDTEESRRLLAMLVLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGL---------------LENAK--GETLE-------LFHSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPTLLFQELDKERKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKEKLGLVETN---TASPHVTHITIRRSRMLEDGYDQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSSGDRLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDISDLGLTLSYDEDVMGQLVCHELVPGGKSIPVTNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAPELQRLISGDNAEIDLDDLKKHTVYYGGFHGSHRVIIWLWDILANDFSSEEKAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKKEPGGRLPTSSTCFNLLKLPNYSKKGILREKLRYAISMNTGFEL 1071
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Xenopus
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:780337])

HSP 1 Score: 672.929 bits (1735), Expect = 0.000e+0
Identity = 419/1112 (37.68%), Postives = 630/1112 (56.65%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSG----SFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSD-NRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+   +     FL+K ++ RE R+    R ++AI IQ   R F+ R  L K+IR E    L+     S K   + + ++ R +  +   F+I+ D+  +                   ++S+ L KD  + WI+    IL+   + L  ++P +  D + + V LT+++       WKI+     S L   ++ I   +   + +      ++ LL  G+ R    LS+ +L  + +L LR     + ++  L  F+I+I+SVPALV H+  +  +   +I  + L  K IL L  + +    +   L  S++LC++ N+I LG L   VL      F +VL+ +L    + +++  S+ +H+H + GW   ++D  +  SM  L  QL+ LW   MIR++F E+  + + +       +S +  +            LP       +F K     +       +   S     + ++C+LY    ++L+QIR  IL G++ L DL  ++W  I   G        ++   S       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  F  +  WL    KP+    +L KE+  A+ LL+Y+PH+I HK RV+LF   +  +K  LGL+  N     SP    I++RR RM+EDGYDQL +++ +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS  +RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD+SDL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT AF  GF SII+ +W  MFS PE+ +LI GD   ID+DDLK++  Y GGFH  HRVI+WLWDIL N+FS  EK++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ KK+    RLP+++TCFNLLKLPNY  K  LREKLRY I+   GFEL
Sbjct:    1 MFGATQVSKAQFLDKARQAREERKGLKERDRAAIKIQALIRRFLCRCRLQKEIRQEVDDFLEGTEKGSVKANALSIFRISRKLLII---FQISQDRMVW-------------------FVSLALSKDLTLLWIKQIKDILWYCSEYLKQLKPDILQDSKLITVYLTMLVTFTDTLTWKILKGKGES-LRPAMNHICANIMGYLNQKGFYSVLQILLTNGLARSRPSLSKGTLTALFSLALRPVVAAQYSDNLLRSFLIHIMSVPALVSHLSTLTPDRLSVIESNGLFHKFILFLSREDQCS-DVCECLEGSHTLCLLGNLIHLGHLTEKVLEEEMFHFVSVLTQMLSYCQKYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLLTKQLQHLWGVHMIRNLFREVLSKKLAENQDVSVPVSQSSSSS-------PQNNLPMKNLFKRAFQKSASVRHILKPIGGKKVDSPEVQKVCNICVLYQMALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLSSDTEESRRLLAMLVLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGL---------------LENAK--GETLE-------LFHSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPTLLFQELDKERKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKEKLGLVETN---TASPHVTHITIRRSRMLEDGYDQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSSGDRLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDISDLGLTLSYDEDVMGQLVCHELVPGGKSIPVTNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAPELQRLISGDNAEIDLDDLKKHTVYYGGFHGSHRVIIWLWDILANDFSSEEKAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTIRKKEPG-GRLPTSSTCFNLLKLPNYSKKGILREKLRYAISMNTGFEL 1051
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Xenopus
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:780337])

HSP 1 Score: 668.692 bits (1724), Expect = 0.000e+0
Identity = 416/1112 (37.41%), Postives = 623/1112 (56.03%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSG----SFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSD-NRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+   +     FL+K ++ RE R+    R ++AI IQ   R F+ R  L K+IR E    L+     S K   + + ++ R +  +   F+I+ D+  +E LCR +L                                  N+ ++    +P +  D + + V LT+++       WKI+     S L   ++ I   +   + +      ++ LL  G+ R    LS+ +L  + +L LR     + ++  L  F+I+I+SVPALV H+  +  +   +I  + L  K IL L  + +    +   L  S++LC++ N+I LG L   VL      F +VL+ +L    + +++  S+ +H+H + GW   ++D  +  SM  L  QL+ LW   MIR++F E+  + + +       +S +  +            LP       +F K     +       +   S     + ++C+LY    ++L+QIR  IL G++ L DL  ++W  I   G        ++   S       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  F  +  WL    KP+    +L KE+  A+ LL+Y+PH+I HK RV+LF   +  +K  LGL+  N     SP    I++RR RM+EDGYDQL +++ +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS  +RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD+SDL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT AF  GF SII+ +W  MFS PE+ +LI GD   ID+DDLK++  Y GGFH  HRVI+WLWDIL N+FS  EK++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +KK    RLP+++TCFNLLKLPNY  K  LREKLRY I+   GFEL
Sbjct:    1 MFGATQVSKAQFLDKARQAREERKGLKERDRAAIKIQALIRRFLCRCRLQKEIRQEVDDFLEGTEKGSVKANALSIFRISRKLLII---FQISQDRMRFEKLCRCIL----------------------------------NSMENDNEPKPDILQDSKLITVYLTMLVTFTDTLTWKILKGKGES-LRPAMNHICANIMGYLNQKGFYSVLQILLTNGLARSRPSLSKGTLTALFSLALRPVVAAQYSDNLLRSFLIHIMSVPALVSHLSTLTPDRLSVIESNGLFHKFILFLSREDQCS-DVCECLEGSHTLCLLGNLIHLGHLTEKVLEEEMFHFVSVLTQMLSYCQKYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLLTKQLQHLWGVHMIRNLFREVLSKKLAENQDVSVPVSQSSSSS-------PQNNLPMKNLFKRAFQKSASVRHILKPIGGKKVDSPEVQKVCNICVLYQMALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLSSDTEESRRLLAMLVLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGL---------------LENAK--GETLE-------LFHSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPTLLFQELDKERKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKEKLGLVETN---TASPHVTHITIRRSRMLEDGYDQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSSGDRLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDISDLGLTLSYDEDVMGQLVCHELVPGGKSIPVTNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAPELQRLISGDNAEIDLDDLKKHTVYYGGFHGSHRVIIWLWDILANDFSSEEKAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKKEPGGRLPTSSTCFNLLKLPNYSKKGILREKLRYAISMNTGFEL 1036
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Xenopus
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:780337])

HSP 1 Score: 641.343 bits (1653), Expect = 0.000e+0
Identity = 407/1113 (36.57%), Postives = 616/1113 (55.35%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLL-TXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSG----SFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSD-NRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+   +     FL+K ++ RE R+    R ++AI IQ   R F+ R  L K+IR E    L+     S K   + + ++ R +  +   F+I+ D+  +E LCR +L +  + ++    ++S+ L KD  + WI+    IL+   + L  ++P +  D + + V LT+++       WKI+     S L   ++ I   +   + +      ++ LL  G+ R    LS+ +L  + +L LR     + ++  L  F+I+I+SVPALV H+  +  +   +I  + L  K IL L  + +    +   L  S++LC++ N+I LG L   VL      F +VL+ +L    + +++  S+ +H+H + GW   ++D  +  SM  L  QL+ LW   MIR++F E+  + + +       +S +  +            LP       +F K     +       +   S     + ++C+LY    ++L+QIR  IL G++ L DL  ++W  I   G        ++   S       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  F  +  WL    KP+    +L KE+  A+ LL+Y+PH+I HK                                            DGYDQL +++ +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS  +RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD+SDL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT AF  GF SII+ +W  MFS PE+ +LI GD   ID+DDLK++  Y GGFH  HRVI+WLWDIL N+FS  EK++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +KK    RLP+++TCFNLLKLPNY  K  LREKLRY I+   GFEL
Sbjct:   16 MFGATQVSKAQFLDKARQAREERKGLKERDRAAIKIQALIRRFLCRCRLQKEIRQEVDDFLEGTEKGSVKANALSIFRISRKLLII---FQISQDRMRFEKLCRCILNSMENDNEPKVWFVSLALSKDLTLLWIKQIKDILWYCSEYLKQLKPDILQDSKLITVYLTMLVTFTDTLTWKILKGKGES-LRPAMNHICANIMGYLNQKGFYSVLQILLTNGLARSRPSLSKGTLTALFSLALRPVVAAQYSDNLLRSFLIHIMSVPALVSHLSTLTPDRLSVIESNGLFHKFILFLSREDQCS-DVCECLEGSHTLCLLGNLIHLGHLTEKVLEEEMFHFVSVLTQMLSYCQKYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLLTKQLQHLWGVHMIRNLFREVLSKKLAENQDVSVPVSQSSSSS-------PQNNLPMKNLFKRAFQKSASVRHILKPIGGKKVDSPEVQKVCNICVLYQMALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLSSDTEESRRLLAMLVLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGL---------------LENAK--GETLE-------LFHSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPTLLFQELDKERKRAQLLLQYIPHVIPHKN-------------------------------------------DGYDQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSSGDRLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDISDLGLTLSYDEDVMGQLVCHELVPGGKSIPVTNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAPELQRLISGDNAEIDLDDLKKHTVYYGGFHGSHRVIIWLWDILANDFSSEEKAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKKEPGGRLPTSSTCFNLLKLPNYSKKGILREKLRYAISMNTGFEL 1046
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Xenopus
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:780337])

HSP 1 Score: 485.337 bits (1248), Expect = 6.892e-153
Identity = 333/981 (33.94%), Postives = 529/981 (53.92%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLL-TXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSG----SFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSD-NRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLK 3068
            M+   +     FL+K ++ RE R+    R ++AI IQ   R F+ R  L K+IR E    L+     S K   + + ++ R +  +   F+I+ D+  +E LCR +L +  + ++    ++S+ L KD  + WI+    IL+   + L  ++P +  D + + V LT+++       WKI+     S L   ++ I   +   + +      ++   L  +  Q   LS ++               + ++  L  F+I+I+SVPALV H+  +  +   +I  + L  K IL L  + +    +   L  S++LC++ N+I LG L   VL      F +VL+ +L    + +++  S+ +H+H + GW   ++D  +  SM  L  QL+ LW   MIR++F E+  + + +       +S +  +            LP       +F K     +       +   S     + ++C+LY    ++L+QIR  IL G++ L DL  ++W  I   G        ++   S       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  F  +  WL    KP+    +L KE+  A+ LL+Y+PH+I HK RV+LF   +  +K  LGL+  N     SP    I++RR RM+EDGYDQL +++ +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS  +RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD+SDL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT AF  GF SII+ +W  MFS PE+ +LI GD   ID+DDLK
Sbjct:    1 MFGATQVSKAQFLDKARQAREERKGLKERDRAAIKIQALIRRFLCRCRLQKEIRQEVDDFLEGTEKGSVKANALSIFRISRKLLII---FQISQDRMRFEKLCRCILNSMENDNEPKVWFVSLALSKDLTLLWIKQIKDILWYCSEYLKQLKPDILQDSKLITVYLTMLVTFTDTLTWKILKGKGES-LRPAMNHICANIMGYLNQKGFYSVLQVCSL--ILAQKTSLSLVA--------------AQYSDNLLRSFLIHIMSVPALVSHLSTLTPDRLSVIESNGLFHKFILFLSREDQCS-DVCECLEGSHTLCLLGNLIHLGHLTEKVLEEEMFHFVSVLTQMLSYCQKYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLLTKQLQHLWGVHMIRNLFREVLSKKLAENQDVSVPVSQSSSSS-------PQNNLPMKNLFKRAFQKSASVRHILKPIGGKKVDSPEVQKVCNICVLYQMALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLSSDTEESRRLLAMLVLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGL---------------LENAK--GETLE-------LFHSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPTLLFQELDKERKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKEKLGLVETN---TASPHVTHITIRRSRMLEDGYDQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSSGDRLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDISDLGLTLSYDEDVMGQLVCHELVPGGKSIPVTNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAPELQRLISGDNAEIDLDDLK 925
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Mouse
Match: Ube3b (ubiquitin protein ligase E3B [Source:MGI Symbol;Acc:MGI:1891295])

HSP 1 Score: 689.108 bits (1777), Expect = 0.000e+0
Identity = 416/1121 (37.11%), Postives = 646/1121 (57.63%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLL-TXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKL---HFSYKASTTN------EXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLI---QNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+T  ++    F+++ ++ RE R ++  R++SA+ IQ   R F+ R+ L + IR E  +    +   S K   + + K+ R    L +  K   D +  E LCR +L +    ++    Y+S+ L KD  + WI+    IL++ C+ LG ++P +  D R + + LT+++     S WKI+     S L   L+ I   +   + +  +   ++ LL +G+ R    LS+  L    +L LR     + ++  + PFII+++SVPALV H+  +  E   ++    +  K I+ L  D          L   ++LC++ N++ LG L + +L      F + L+ +L    + + +  S+ +H+H + GW    +D  +  SM  +  QL+ LW+  +IR +F ++  + +L+                   P+   P  P +    K L    F   AS  N       +   S     + ++C+LY  + ++L+QIR  IL G++ L DL  ++W  I      G +K +   + ++D+G   Q  +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   VE AK  G+ L+       LF S +  LMVL+ER+ R  F  +  WL    KP     +L K++  A+ +L+++PH++ HK RV+LF   +  +K  LGL+  +     SP    I++RR RM+EDGY+QL +++    K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS D RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD++DL LT SYDED +G++  H+L PGG+ I VT++ KISY+H++A FRM  QI++QT A   GF SII+ +W  MFS PE+ +LI GD   ID++DLK++  Y GGFH  HRVI+WLWDIL ++F+  E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +K+    RLP+++TCFNLLKLPNY  KS LREKLRY I+   GFEL
Sbjct:    1 MFTVSQTSRAWFIDRARQAREERLVQKERERSAVTIQALVRSFLCRRRLHRDIRKEIDEFFSADESGSSKRSALCIFKIARR---LLFICKTTEDSERLEKLCRSILNSMDAENEPKVWYVSLALSKDLTLLWIKQIKSILWHCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGES-LRPALNHICANIMGHLNQRGLYSVLQVLLTRGLARPRPCLSKGMLTAAFSLALRPVVAAQFSDNLMRPFIIHVMSVPALVAHLSTVAPERLGVLESHDMLRKFIVFLR-DRDRCRDACESLEGCHTLCLMGNLLHLGSLSLRLLEEEMDGFVSALTQMLCYCQKYVAQKKSNLTHWHPVLGWFSQPVDYGLNDSMYLITKQLQFLWAVPLIRILFSDILSRKLLEHAE--------------PAPVQPQPSSPQTVLPVKSLLKRAFQKSASVRNILRPVGGRRVDSAEVRKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECL-NNDTGESKQ--LLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGI---------------VENAK--GETLE-------LFQSVHGWLMVLYERDCRRRFAPEDHWLRRDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETS---SASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1069
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Mouse
Match: Ube3c (ubiquitin protein ligase E3C [Source:MGI Symbol;Acc:MGI:2140998])

HSP 1 Score: 285.804 bits (730), Expect = 1.988e-79
Identity = 166/436 (38.07%), Postives = 252/436 (57.80%), Query Frame = 3 
Query: 2166 LLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPI--GAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLL-FQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            +L  +P ++  +ERV +F   I ADK  +          D P   G  +++RR  + ED YD+L   N  D KK+IRV  +N  G+DE GID  G+F+EFL E LK+  NP+   F TT++  LYP+P + +   +     + +LGRM+ KA+YE +L+E PFA FFL+++L    ++    I  L +LD ++Y++L ++K Y+ DV +L L F+   + LG+ +  +L+ GG+ I VT   +I+Y+H+VA +R+ +QIR    AF+ G  +++  +W  MF   E+  LI G    + ++DLK    YSGG+ A H VI   W +++  F++ EK   LKFVTSCS+PPLLGF  L P+F   C+H+                         +D++RLP+A+TC NLLKLP +  ++ LR KL Y I   AGFEL
Sbjct:  685 ILTELPFVVPFEERVKIFQRLIYADKQEV--------QGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLG---TSADVDIHHLASLDPEVYRNLLFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADHPVIKIFWRVVEG-FTDEEKRKLLKFVTSCSRPPLLGFKELYPAF---CIHNGG-----------------------SDLERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFEL 1082
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Mouse
Match: Nedd4 (neural precursor cell expressed, developmentally down-regulated 4 [Source:MGI Symbol;Acc:MGI:97297])

HSP 1 Score: 175.637 bits (444), Expect = 3.128e-44
Identity = 132/431 (30.63%), Postives = 209/431 (48.49%), Query Frame = 3 
Query: 2178 VPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDF-KKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLF--CTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFE 3461
            VP+   +K +   F  K+K                D P    + +RR  ++ED Y ++M V   D  K ++ + F  E      G+D  GV +E+     K + NP   LF    T +  L  +P SGL  ++HL  F+++GR+   A+Y   L++  F   F   +L K  +     + ++ ++D + Y SL ++   + D ++L+L F  DE+  G+   H+L+ GG  I VTN  K  Y+++V ++R   +I+ Q  AFK GF+ +I +D   +F   E+  L+CG  G +DV+D +++ +Y  G+   H+VI W W  +    SE    L L+FVT  S+ P+ GFA L                      GS     FT+ +     K LP A TCFN L LP YES   L +KL+  I +  GF+
Sbjct:  503 VPYSRDYKRKYEFFRRKLK-------------KQTDIPNKFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFDGE-----KGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLIT-----LHDMESVDSEYYSSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG-LGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRL-LQFVTGTSRVPMNGFAEL---------------------YGSNGPQSFTVEQWGTPDK-LPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFD 884
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Mouse
Match: Huwe1 (HECT, UBA and WWE domain containing 1 [Source:MGI Symbol;Acc:MGI:1926884])

HSP 1 Score: 176.022 bits (445), Expect = 1.268e-43
Identity = 131/390 (33.59%), Postives = 188/390 (48.21%), Query Frame = 3 
Query: 2301 VISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRL-YPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGA-GFEL 3464
             + VRR  + ED Y +L + + ++ K ++ + F  E G D       G+ +E+     + + NP   LF T+  +R+ Y    S     NHL  F+++GR++AKA+Y+  L+E  F   F   +L K  S  Y+   ++ + D   Y+ L Y+   D      +LTFS +    G  E  DL+P G  I VT + K  YVH+V + RM   IR Q  AF  GFY II +    +F+  E+  LI G    ID+DDLK N  Y   + +    I W W  L++ F + +++ FL+FVT  SK PL GFA LE    I+                      F + +      RLPSA TCFN L LP YES   LR  L   I   + GF L
Sbjct: 4022 AVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDA-----GGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGK--SVRYT---DMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISG-LPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRS-FDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQ---------------------KFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGL 4377
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Mouse
Match: Huwe1 (HECT, UBA and WWE domain containing 1 [Source:MGI Symbol;Acc:MGI:1926884])

HSP 1 Score: 176.022 bits (445), Expect = 1.279e-43
Identity = 131/390 (33.59%), Postives = 188/390 (48.21%), Query Frame = 3 
Query: 2301 VISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRL-YPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGA-GFEL 3464
             + VRR  + ED Y +L + + ++ K ++ + F  E G D       G+ +E+     + + NP   LF T+  +R+ Y    S     NHL  F+++GR++AKA+Y+  L+E  F   F   +L K  S  Y+   ++ + D   Y+ L Y+   D      +LTFS +    G  E  DL+P G  I VT + K  YVH+V + RM   IR Q  AF  GFY II +    +F+  E+  LI G    ID+DDLK N  Y   + +    I W W  L++ F + +++ FL+FVT  SK PL GFA LE    I+                      F + +      RLPSA TCFN L LP YES   LR  L   I   + GF L
Sbjct: 4021 AVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDA-----GGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGK--SVRYT---DMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISG-LPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRS-FDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQ---------------------KFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGL 4376
[Close]
BLAST of HECT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7Z3V4|UBE3B_HUMAN (Ubiquitin-protein ligase E3B OS=Homo sapiens OX=9606 GN=UBE3B PE=1 SV=3)

HSP 1 Score: 694.115 bits (1790), Expect = 0.000e+0
Identity = 413/1109 (37.24%), Postives = 647/1109 (58.34%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXX-XXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+T  ++    F+++ ++ RE R ++  R+++A++IQ + R F+ R  L + IR E       ++ +S K   + + K+ R    L + F+I  D + +E LCR +L+S+D+       Y+S+   KD  + WI+    IL+  CD L  ++P +  D R + + LT+++     S WKI+     S L   ++ I   +   + +      ++ LL +G+ R    LS+ +L    +L LR     + ++  + PF+I+I+SVPALV H+  +  E   ++    +  K I+ L  D      +   L   ++LC++ N++ LG L   VL      F ++L+  L    + +++  S+ +H+H + GW   S+D  +  SM  +  QL+ LW   +IR  F ++  + +L+      +  ++ +N   +  + K        +F K             +   S     + ++C+LY  + ++L+QIR  IL G++ L DL  ++W  I   G        ++  ++       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   VE AK  G+ L+       LF S +  LMVL+ER+ R  FT +  WL    KPS    +L +++  A+ +L+Y+PH+I HK RV+LF   +  +K  LGL+  +     SP    I++RR RM+EDGY+QL +++    K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS D RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD++DL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT A   GF SII+ +W  MFS PE+ +LI GD   ID++DLK++  Y GGFH  HRVI+WLWDIL ++F+ +E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +K+    RLP+++TCFNLLKLPNY  KS LREKLRY I+   GFEL
Sbjct:    1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARK---LLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGES-LRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLR-DQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASPQNVLPVKSLLK-------RAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGI---------------VENAK--GETLE-------LFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETS---SASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
[Close]
BLAST of HECT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9ES34|UBE3B_MOUSE (Ubiquitin-protein ligase E3B OS=Mus musculus OX=10090 GN=Ube3b PE=1 SV=3)

HSP 1 Score: 689.108 bits (1777), Expect = 0.000e+0
Identity = 416/1121 (37.11%), Postives = 646/1121 (57.63%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLL-TXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKL---HFSYKASTTN------EXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLI---QNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+T  ++    F+++ ++ RE R ++  R++SA+ IQ   R F+ R+ L + IR E  +    +   S K   + + K+ R    L +  K   D +  E LCR +L +    ++    Y+S+ L KD  + WI+    IL++ C+ LG ++P +  D R + + LT+++     S WKI+     S L   L+ I   +   + +  +   ++ LL +G+ R    LS+  L    +L LR     + ++  + PFII+++SVPALV H+  +  E   ++    +  K I+ L  D          L   ++LC++ N++ LG L + +L      F + L+ +L    + + +  S+ +H+H + GW    +D  +  SM  +  QL+ LW+  +IR +F ++  + +L+                   P+   P  P +    K L    F   AS  N       +   S     + ++C+LY  + ++L+QIR  IL G++ L DL  ++W  I      G +K +   + ++D+G   Q  +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   VE AK  G+ L+       LF S +  LMVL+ER+ R  F  +  WL    KP     +L K++  A+ +L+++PH++ HK RV+LF   +  +K  LGL+  +     SP    I++RR RM+EDGY+QL +++    K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS D RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD++DL LT SYDED +G++  H+L PGG+ I VT++ KISY+H++A FRM  QI++QT A   GF SII+ +W  MFS PE+ +LI GD   ID++DLK++  Y GGFH  HRVI+WLWDIL ++F+  E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +K+    RLP+++TCFNLLKLPNY  KS LREKLRY I+   GFEL
Sbjct:    1 MFTVSQTSRAWFIDRARQAREERLVQKERERSAVTIQALVRSFLCRRRLHRDIRKEIDEFFSADESGSSKRSALCIFKIARR---LLFICKTTEDSERLEKLCRSILNSMDAENEPKVWYVSLALSKDLTLLWIKQIKSILWHCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGES-LRPALNHICANIMGHLNQRGLYSVLQVLLTRGLARPRPCLSKGMLTAAFSLALRPVVAAQFSDNLMRPFIIHVMSVPALVAHLSTVAPERLGVLESHDMLRKFIVFLR-DRDRCRDACESLEGCHTLCLMGNLLHLGSLSLRLLEEEMDGFVSALTQMLCYCQKYVAQKKSNLTHWHPVLGWFSQPVDYGLNDSMYLITKQLQFLWAVPLIRILFSDILSRKLLEHAE--------------PAPVQPQPSSPQTVLPVKSLLKRAFQKSASVRNILRPVGGRRVDSAEVRKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECL-NNDTGESKQ--LLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGI---------------VENAK--GETLE-------LFQSVHGWLMVLYERDCRRRFAPEDHWLRRDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETS---SASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1069
[Close]
BLAST of HECT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q08CZ0|UBE3B_XENTR (Ubiquitin-protein ligase E3B OS=Xenopus tropicalis OX=8364 GN=ube3b PE=2 SV=1)

HSP 1 Score: 688.337 bits (1775), Expect = 0.000e+0
Identity = 424/1113 (38.10%), Postives = 640/1113 (57.50%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLL-TXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSG----SFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSD-NRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+   +     FL+K ++ RE R+    R ++AI IQ   R F+ R  L K+IR E    L+     S K   + + ++ R +  +   F+I+ D+  +E LCR +L +  + ++    ++S+ L KD  + WI+    IL+   + L  ++P +  D + + V LT+++       WKI+     S L   ++ I   +   + +      ++ LL  G+ R    LS+ +L  + +L LR     + ++  L  F+I+I+SVPALV H+  +  +   +I  + L  K IL L  + +    +   L  S++LC++ N+I LG L   VL      F +VL+ +L    + +++  S+ +H+H + GW   ++D  +  SM  L  QL+ LW   MIR++F E+  + + +       +S +  +            LP       +F K     +       +   S     + ++C+LY    ++L+QIR  IL G++ L DL  ++W  I   G        ++   S       +  +L +F   +R+L  ILDD EV+E++  F + ELV ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  F  +  WL    KP+    +L KE+  A+ LL+Y+PH+I HK RV+LF   +  +K  LGL+  N     SP    I++RR RM+EDGYDQL +++ +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + +P+LNLF TTS  +RLYPSP S ++E N+L LF+++G+M+ KA+YE I+++ PFA+FFL+Q+L    S  YS +DEL +LD + YK+LT +K YDGD+SDL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT AF  GF SII+ +W  MFS PE+ +LI GD   ID+DDLK++  Y GGFH  HRVI+WLWDIL N+FS  EK++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +KK    RLP+++TCFNLLKLPNY  K  LREKLRY I+   GFEL
Sbjct:    1 MFGATQVSKAQFLDKARQAREERKGLKERDRAAIKIQALIRRFLCRCRLQKEIRQEVDDFLEGTEKGSVKANALSIFRISRKLLII---FQISQDRMRFEKLCRCILNSMENDNEPKVWFVSLALSKDLTLLWIKQIKDILWYCSEYLKQLKPDILQDSKLITVYLTMLVTFTDTLTWKILKGKGES-LRPAMNHICANIMGYLNQKGFYSVLQILLTNGLARSRPSLSKGTLTALFSLALRPVVAAQYSDNLLRSFLIHIMSVPALVSHLSTLTPDRLSVIESNGLFHKFILFLSREDQCS-DVCECLEGSHTLCLLGNLIHLGHLTEKVLEEEMFHFVSVLTQMLSYCQKYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLLTKQLQHLWGVHMIRNLFREVLSKKLAENQDVSVPVSQSSSSS-------PQNNLPMKNLFKRAFQKSASVRHILKPIGGKKVDSPEVQKVCNICVLYQMALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLSSDTEESRRLLAMLVLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGL---------------LENAK--GETLE-------LFHSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPTLLFQELDKERKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKEKLGLVETN---TASPHVTHITIRRSRMLEDGYDQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSSGDRLYPSPTSYIHE-NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDISDLGLTLSYDEDVMGQLVCHELVPGGKSIPVTNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAPELQRLISGDNAEIDLDDLKKHTVYYGGFHGSHRVIIWLWDILANDFSSEEKAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKKEPGGRLPTSSTCFNLLKLPNYSKKGILREKLRYAISMNTGFEL 1071
[Close]
BLAST of HECT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8RWB8|UPL6_ARATH (E3 ubiquitin-protein ligase UPL6 OS=Arabidopsis thaliana OX=3702 GN=UPL6 PE=2 SV=1)

HSP 1 Score: 336.65 bits (862), Expect = 1.258e-96
Identity = 209/626 (33.39%), Postives = 343/626 (54.79%), Query Frame = 3 
Query: 1641 TDLPARMWRLIQNSGSVKQWANIIK-----DSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVV-VSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFV---------AKFLLKYVPHIIAHKERVVLFHEKIKADK---ASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            T+L A +W  ++     ++W+++ K       D+  +  P V     +F  + +++ +I+D+ E +E+EK  ++ ++  +         +++ V+  ++    K +S      + +KK+  +L     M  + S    LL  L + N R  FT+           S F AD   E F+         A ++L   P +I    RV +F  ++   +    S G+ +RN             +RR  ++ED Y+Q+  ++ DD +  IRV F+NELG++E GID  G+FK+F+E+  +   +    LF  T+D+ LYP+P SG+  + HL  F +LG ++AKA++E IL++ PFA FFL+++  K     Y+++++L +LD +LY+ L ++K Y GD+SDLEL F    +  G+    +L PGG+ + VTN+  I+++H+V+  R+  QIR Q+  F  GF  +I ++W DMF+  E+  LI G    +D+DDL+ N  Y+GG+HAGH VI   W+++K+  +EN+K  FLKFVT CS+ PLLGF YLEP+F I+    S  ++                      + RLP++ATC NLLKLP Y+SK  L  KL Y I++ AGF+L
Sbjct:  464 TELVAVLWNYMKRCHENQKWSSMPKLLAYLPGDAPGWLLPLV-----VFCPVYKHMLMIVDNEEFYEREKPLSLQDIRLLIIILKQALWQLLWVNPLTQPNTGKSVSN-----DLSKKNPIELIQN-RMGIVVSE---LLSQLQDWNNRKQFTSS----------SDFQADSVNEYFISQAIMEGTRANYILMQAPFLIPFTSRVKIFTTQLATARQSHGSQGIFARNR----------FRIRRDHILEDAYNQMSALSEDDLRSSIRVTFVNELGVEEAGIDGGGIFKDFMEKITRAAFDVQYGLFKETADHMLYPNPGSGMIHEQHLQFFHFLGSLLAKAMFEGILVDIPFATFFLSKLKQK-----YNYLNDLPSLDPELYRHLIFLKRYKGDISDLELYFVILNNEYGERTEEELLPGGQDMRVTNENVITFIHLVSNHRLNFQIRQQSSHFLRGFQQLIPKEWIDMFNEHELQVLISGSVDSLDIDDLRNNTNYAGGYHAGHYVIDMFWEVMKSFSTENQKK-FLKFVTGCSRGPLLGFKYLEPAFCIQRAAGSASNE---------------------SVDRLPTSATCMNLLKLPPYQSKELLETKLMYAISAEAGFDL 1028
[Close]
BLAST of HECT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9SCQ2|UPL7_ARATH (E3 ubiquitin-protein ligase UPL7 OS=Arabidopsis thaliana OX=3702 GN=UPL7 PE=2 SV=1)

HSP 1 Score: 337.806 bits (865), Expect = 3.336e-96
Identity = 215/588 (36.56%), Postives = 312/588 (53.06%), Query Frame = 3 
Query: 1749 VSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLS---SSHKPSQFMADLKKEKFVAKFL--------LKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAV---ISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLF--CTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            VS LLH+F     +L ++LDD + +EK+  F + +   +A   N L    ++  T                              E   L  S    L +L+ER+ RHPF     WLS   +S  P  F A   +    +  L        +   PH+   +ERV +F E I  DKAS  +        D+P GA    I VRR  +VEDG+ QL  + +   K  I V F+NE G+ E G+D  G+ KEFL +  K        LF    TSD  L PSP S  + +N + + ++LGR++ KA+YE IL++  F++ F+ ++L +     YSFIDEL+ LD +LY++L YVKHYDGD+ +L L F+  E+  GK+   +L+PGG+  +VTN+ K+ Y+H +A +++ +QI   + AF  G   +I   W  +F+  E  +L+ G    IDVDDL++N +Y+GG+    R I   W+++K  F  +E+ L LKFVTSCS+ PLLGF YL+P+F I   H    D      +G              D++RLPSA+TC+N LKLP Y+  ST+REKL Y I S AGFEL
Sbjct:  610 VSCLLHLFCATYAHLLVVLDDIQFYEKQVPFMLEKQQRIASMLNTLVYYGLLRGTGP----------------------------ESRQLMDSAIRCLHLLYERDCRHPFCASALWLSPGRTSRPPIAFAARTHEVLPTSDVLTTPSMGSVITITPHVFPFEERVHVFREFISKDKASRKMA----GEVDAP-GARSIEIVVRRGHVVEDGFQQLNSIGSR-LKSSIHVSFVNESGLPEAGLDYGGLSKEFLTDITKAAFATEYGLFSQTPTSDRLLVPSP-SARHLENGIQMIEFLGRIVGKALYEGILLDYSFSHVFIQKLLGR-----YSFIDELSGLDPELYRNLMYVKHYDGDLKELCLDFTVTEEFCGKMSIIELKPGGKDTSVTNENKMQYIHAMADYKLNRQIVPFSNAFYRGLTDLISPAWLKLFNAHEFNQLLSGGNHDIDVDDLRRNTKYTGGYSDSSRTIKIFWEVMKG-FEPSERCLLLKFVTSCSRAPLLGFKYLQPTFII---HKVSCDTSLWAAIGG------------QDVERLPSASTCYNTLKLPTYKRASTMREKLLYAITSNAGFEL 1141
[Close]
BLAST of HECT domain-containing protein vs. TrEMBL
Match: A0A4E0RH02 (Putative ubiquitin-protein ligase OS=Fasciola hepatica OX=6192 GN=D915_003810 PE=4 SV=1)

HSP 1 Score: 744.191 bits (1920), Expect = 0.000e+0
Identity = 372/644 (57.76%), Postives = 473/644 (73.45%), Query Frame = 3 
Query: 1566 VCMLYFFTTSSLSQIRDDILAGVSLTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAK-----KSGKDLKGT-----VEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSR-NWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            VCMLY FT +SL +IR+DILAG+SL DL  R+WRL+   G+V+ W  ++ DS  G +++PH SHLLHIF   A NL  ILDD E+FE +K FT  EL  M  FFN L  E V++      L+   S         +     KS     GT       +  LF+ C  LL +++ER+ RHPFT   FWL  + K S F+ADL+K K  A FLLK VPHII HKERV+LF E+++ DKASLG+ +R NW  DD P+GAVI++ R R+VEDGY QL  +++   + KIRV+F+NELG+DEVGIDLDGVFKEFLEETL  + +PSLNLF  TSD RLYPSP S L ++NHLLLF++LG+M+AKAIYE I+++ PFANFFLTQ+L +E++  YSF+DEL TLD++LYKSL+Y+KHYDGDV+DLE T+SY ED LG++  HDL PGGR ITVTND KISYVH VA FRM++QIR QT +F  GFYSI+  DW  +FS PE+ KLI GD+  +++DDL+QN RYSGGFH+ HRVI WLWDIL+ +FS+ E+SLFLKFVTSCS+PPLLGF+ LEP F IRCV  ++EDQ+  DT+GS+LK  F +  ++ ++ RLP+ +TCFNLLKLPNY S+S LR+KLRY I S AGFEL
Sbjct:  526 VCMLYCFTVTSLREIRNDILAGLSLGDLLPRLWRLVARCGTVQDWVKVLMDSKLGVHAKPHASHLLHIFTAAASNLLSILDDVELFELDKSFTADELCSMGAFFNQLVYETVLAVPDPWALHSWSSPTAPKPSVGEPLPTTKSESGALGTQNPTACTLPGLFTMCLRLLSIIYERDSRHPFTPPDFWLIPNLKVSAFLADLRKSKPHALFLLKNVPHIIPHKERVMLFRERVRDDKASLGVQTRMNWLTDDGPVGAVITIHRNRLVEDGYQQLANLSSTQLRMKIRVQFVNELGLDEVGIDLDGVFKEFLEETLHRVFDPSLNLFRVTSDQRLYPSPSSNL-QENHLLLFEFLGKMLAKAIYEGIVVDVPFANFFLTQLLGRERAGCYSFLDELATLDRELYKSLSYIKHYDGDVADLEFTYSYAEDCLGQVVVHDLCPGGRCITVTNDLKISYVHRVAHFRMYKQIRAQTASFIRGFYSILNPDWLSIFSPPELQKLISGDSISVNIDDLRQNTRYSGGFHSNHRVIKWLWDILRRDFSDEERSLFLKFVTSCSRPPLLGFSNLEPPFCIRCVQYTNEDQDVGDTLGSVLKGFFGVGVRREEVTRLPTTSTCFNLLKLPNYSSRSVLRDKLRYAIRSHAGFEL 1168

HSP 2 Score: 226.098 bits (575), Expect = 2.290e-56
Identity = 137/413 (33.17%), Postives = 236/413 (57.14%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFR-QCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILD 1382
            M+  +K +V  F+EK +KER  RR   +R+KSA++IQ+ +RG+  R   +     EFR  C +I   ++        ++L+RA + L + F   +D++ +E L R++++SI++ K   SY+++ L+K ++V WIR++ WI  +    L +++P      + +NV L+L++ I    RW       +++L   ++++T      +L   + + +  LL KG+ R +   ++ SL GI T+ +R        + Y+  F   IL+VP  V H++ M+NE++  +LR+RLCTK +L L  +P     + + L  SY LC IAN+I L LLE ++LA H S+FC VLS LL  L   +    S+ S +H I GW    +D ++Q++M  +  QL+LLW+ +M+R +F +LY +  LD
Sbjct:    1 MFDRIKPDVDVFIEKNRKERCERREARIREKSAVMIQKVWRGYHARSQALF----EFRCSCDNIIARET------SADELLRATRYLSFRFSPENDRQRFEILVRRIMSSIETGKPETSYLALALRKATLVHWIRVTKWIFASIVHYLASLDPCNPTSSKTLNVFLSLLLVITDYPRWTFY----DAHLEPSMNQLTRIFLEDLLHNGLYERLHILLAKGLARHSPMFTKTSLTGIFTVAMRPLIYSDFAQKYMLMFASQILAVPGFVLHVNSMMNEVYDTVLRERLCTKTVLILCDNPNELDSLVASLDGSYVLCFIANLIQLSLLEGEILAVHCSKFCVVLSKLLSHLGTYVGSKKSTMSSWHPILGWFAQPLDTSLQAAMTFVTKQLRLLWNGRMVRMLFGDLYAETELD 399
[Close]
BLAST of HECT domain-containing protein vs. TrEMBL
Match: A0A0X3QG23 (HECT domain-containing protein OS=Schistocephalus solidus OX=70667 GN=TR160909 PE=4 SV=1)

HSP 1 Score: 743.421 bits (1918), Expect = 0.000e+0
Identity = 372/641 (58.03%), Postives = 482/641 (75.20%), Query Frame = 3 
Query: 1566 VCMLYFFTTSSLSQIRDDILAGVSLTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKL-ISTREIDVERAKKSGKDL-----KGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSR-NWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTM-SKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            VCMLY FT  SL +IR+DILAG++L DL  RMWRLI ++G V+ WA ++    +GW  +PH SHLLH+F   A NL IILDD EVFEK+K F + EL+ ++DFFNHL  E V+     + L  + IS ++     ++ +  D      + ++   T+F+ C  LL VL++R+ R  FT + FWL    KPS F+ADL+KEK  A FLLK+VPHII  KERV+LF E ++A+KASLG+LS+ N   D + +GAVI + R R+VEDGY QL  ++T   + KIRV+FIN +G+DEVGIDLDGVFKEFLEE+L+ + +PSLNLF  T+D RLYPSP S + +  HL LF+++G+++AKA+YE I+++ PFANFFLTQ+L +++++ YSF+DEL T D+DLYKSLTYVKHY+GDVSDLELTFSYDED LG+I  HDL PGGRYITVTND KISYVH VA FRM++QIR QT +F  GFYSII  DW  MFS  E+ +LI GD+ LID++DL+Q+ +YSGGF++ HRVI WLWDIL+ +F+  E+SLFLKFVTSCSKPPLLGFAYLEP F IRCV  ++EDQ+  DT+GS+LK  F   S++  +  RLPSA+TCFNLLKLPNY S+S LR+KLRY I+S +GFEL
Sbjct:  545 VCMLYCFTIGSLKEIRNDILAGLTLGDLLPRMWRLISHAGCVRDWAAVLASPQAGWQLEPHASHLLHLFTAAASNLLIILDDVEVFEKQKAFELEELMAISDFFNHLIYETVLLMPDPSTLLLVDISQKQAASSPSRPNASDSAINGSQSSLTGPTVFAICLRLLGVLYDRDGRRRFTPEGFWLIKELKPSAFLADLRKEKVHATFLLKHVPHIIPRKERVILFRELVRANKASLGILSQTNCMLDSAAVGAVIMIHRNRIVEDGYQQLANLSTTQLRMKIRVQFINAMGLDEVGIDLDGVFKEFLEESLRRVFDPSLNLFRVTTDQRLYPSPTSHI-QDGHLQLFEFVGKLLAKAVYEGIIVDVPFANFFLTQILGRQRASCYSFLDELATFDRDLYKSLTYVKHYEGDVSDLELTFSYDEDCLGQIVVHDLVPGGRYITVTNDLKISYVHRVALFRMYKQIRAQTASFVRGFYSIINPDWLAMFSPLELQQLISGDSVLIDLEDLRQHTKYSGGFYSNHRVITWLWDILRRDFTNEERSLFLKFVTSCSKPPLLGFAYLEPPFCIRCVQYTNEDQDVGDTLGSVLKGFFGFGSRRGEEQARLPSASTCFNLLKLPNYASRSVLRDKLRYAIHSNSGFEL 1184

HSP 2 Score: 234.958 bits (598), Expect = 3.398e-59
Identity = 147/418 (35.17%), Postives = 243/418 (58.13%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDI---NNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNR 1391
            M++ +K EV SF+EK K ERE RR E  R+++A+ IQ+ +RG+  R+ + ++      Q LD    ++D     +P  +  L + I  L+YNF  N D+ N+E  CR L+ S++S     SYIS+VL++D ++ WI  + WIL         I P+   D   MN++L+L + +   ++WK++       L   ++K+T +L   ++ +++   ++ +L KG+      L+QISL GI +L +R           L PFI++ILSVP  V H++ +  E + + +R+RLC+ +I++L   P+NQ  I   L  SY+LC+IAN+I L LLE++VL  H  EFC V+S LL +L   +    S+ + +H I GW    +D  +Q+++ H+ NQL+LLW  +M+R +F +LY+Q  LD  +
Sbjct:    1 MFSDVKPEVRSFIEKQKHEREQRRSERQRERAAVTIQKNWRGYACRRRVHQECCLYVTQFLDSAKSSDDKQFNLQPATI--LPQIILRLKYNFDANEDRMNFESFCRYLIHSLNSEDKELSYISLVLRRDFLIRWISNTRWILSTVVKYFKIINPSSASDSNFMNILLSLTLILTNSAQWKVI---TEEKLKTGMTKLTKSLVVHLVSSDLFPALQIMLKKGLALHIPVLTQISLTGIFSLAMRPLLLTDFAPQNLSPFILHILSVPGFVLHINSLTPEAYDVFVRERLCSHVIMYLSESPQNQRLILDGLEGSYALCLIANLIHLSLLEVEVLVEHCEEFCIVVSKLLDRLGGYVGRKKSNLTSWHPILGWFAQPLDNYLQAAVPHVTNQLRLLWHGRMVRLLFADLYEQEDLDGTQ 413
[Close]
BLAST of HECT domain-containing protein vs. TrEMBL
Match: G7YG62 (Ubiquitin-protein ligase E3 B OS=Clonorchis sinensis OX=79923 GN=CLF_107116 PE=4 SV=1)

HSP 1 Score: 743.036 bits (1917), Expect = 0.000e+0
Identity = 373/636 (58.65%), Postives = 470/636 (73.90%), Query Frame = 3 
Query: 1566 VCMLYFFTTSSLSQIRDDILAGVSLTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVE--RAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSR-NWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            VCMLY F   SL +I++DILAG+SL DL  R+WRLI   GSV  W  I+ DS+  W+ +PH SHL+HIF   A NL  ILDD E+F+  K F+V EL  M  FFNHL  E V++     +L     T   D    +A+ S   L  T     LFS C  LL ++ ER+ R+ FT   FWL S+ + S  +ADL+K K  A FLLK VPHII HKERV+LF ++++ DKASLG+ +R NW  DD P+GAVI+V R R+VEDGY QL  +N+   + KIRV+F+NE+G+DEVGIDLDGVFKEFLEETL  + +PSLNLF  TSD RLYPSP S + + NHL+LF++LG+M+AKAIYE I+++ PFANFFLTQ+L +E++  YSF+DEL TLDK+LYKSL+Y+KHYDGDV+DLE T+SY ED LG++  HDL PGGRYITVTND KISYVH VA FRM++QIR QT +F  GFYSI+  DW  MFS PE+ KLI GD+  ++++DLKQN RYSGGFH+ HRVI WLWDIL+ +FS+ E+ LFLKFVTSCS+PPLLGFA LEP F IRCV  ++EDQ+  DT+GS+LK  F +  ++ +I RLP+ +TCFNLLKLPNY S+S LR+KLRY I+S AGFEL
Sbjct:  298 VCMLYCFNVGSLREIKNDILAGLSLGDLLPRLWRLIARCGSVVDWVKILTDSNPVWHLEPHASHLMHIFTAAASNLLSILDDVELFQLNKSFSVDELCSMGTFFNHLVYETVMAVPDPWKLCNGSGTNAKDASSTKAECSPSPLSVTT-FPDLFSMCLRLLSIIHERDSRYQFTPANFWLLSNLRISTLLADLRKPKPHALFLLKNVPHIIPHKERVLLFRDRVRDDKASLGVQTRMNWLTDDGPVGAVITVHRNRLVEDGYQQLANLNSSQLRMKIRVQFVNEMGLDEVGIDLDGVFKEFLEETLHRVFDPSLNLFRVTSDQRLYPSPSSHV-QDNHLMLFEFLGKMLAKAIYEGIVVDVPFANFFLTQLLGREKAGCYSFLDELATLDKELYKSLSYIKHYDGDVADLEFTYSYAEDSLGQMVVHDLCPGGRYITVTNDLKISYVHRVAHFRMYKQIRAQTASFIRGFYSILNPDWLAMFSPPELQKLISGDSISVNIEDLKQNTRYSGGFHSNHRVIKWLWDILRRDFSDAERGLFLKFVTSCSRPPLLGFANLEPPFCIRCVQYTNEDQDVGDTLGSVLKGFFGVGGRREEISRLPTTSTCFNLLKLPNYSSRSVLRDKLRYAIHSHAGFEL 931

HSP 2 Score: 145.591 bits (366), Expect = 1.949e-31
Identity = 78/199 (39.20%), Postives = 119/199 (59.80%), Query Frame = 3 
Query:  789 LLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDK 1385
            LL KG+ R T   +  SL G+ TL +R        +  L  F   IL+VP L+ H+  M+NE + +I+++RLC+KIIL  H+  +    + S +   Y LC IAN+I L LLE +V+A H SEFC V+S L+  L+  +    S+ S +H I GW    +D ++QS+M  +  QL+LLW+++M+R +F +LY Q  LD+
Sbjct:   20 LLCKGLARHTPAFTSTSLTGLFTLAVRPLLYSDFNKNKLIVFTSQILTVPGLILHVSSMMNESYDVIVKERLCSKIILLYHNHAEELELLVSSVEGPYVLCFIANLIQLSLLEEEVIALHCSEFCVVVSKLMRHLSNYVGSKKSNLSSWHPILGWFAQPLDNSLQSAMPFVTKQLRLLWNNRMVRLLFGDLYAQTELDE 218
[Close]
BLAST of HECT domain-containing protein vs. TrEMBL
Match: A0A075A6X4 (HECT domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_00010 PE=4 SV=1)

HSP 1 Score: 742.265 bits (1915), Expect = 0.000e+0
Identity = 373/636 (58.65%), Postives = 470/636 (73.90%), Query Frame = 3 
Query: 1566 VCMLYFFTTSSLSQIRDDILAGVSLTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVE--RAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSR-NWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            VCMLY F   SL +I++DILAG+SL DL  R+WRLI   GSV  W  I+ DS+  W+ +PH SHL+HIF   A NL  ILDD E+F+  K F+V EL  M  FFNHL  E V++     +L     T   D    +A+ S   L  T     LFS C  LL ++ ER+ R+ FT   FWL S+ + S  +ADL+K K  A FLLK VPHII HKERV+LF ++++ DKASLG+ +R NW  DD P+GAVI+V R R+VEDGY QL  +N+   + KIRV+F+NE+G+DEVGIDLDGVFKEFLEETL  + +PSLNLF  TSD RLYPSP S + + NHL+LF++LG+M+AKAIYE I+++ PFANFFLTQ+L +E++  YSF+DEL TLDK+LYKSL+Y+KHYDGDV+DLE T+SY ED LG++  HDL PGGRYITVTND KISYVH VA FRM++QIR QT +F  GFYSI+  DW  MFS PE+ KLI GD+  ++++DLKQN RYSGGFH+ HRVI WLWDIL+ +FS+ E+ LFLKFVTSCS+PPLLGFA LEP F IRCV  ++EDQ+  DT+GS+LK  F +  ++ +I RLP+ +TCFNLLKLPNY S+S LR+KLRY I+S AGFEL
Sbjct:  496 VCMLYCFNVGSLREIKNDILAGLSLGDLLPRLWRLIARCGSVVDWVKILTDSNPVWHLEPHASHLMHIFTAAASNLLSILDDVELFQLNKSFSVDELCSMGTFFNHLVYETVMAVPDPWKLCSGSGTNAKDASTTKAECSPSPLSVTT-FPDLFSMCLRLLSIIHERDSRYQFTPANFWLLSNLRISTLLADLRKPKPHALFLLKNVPHIIPHKERVLLFRDRVRDDKASLGVQTRMNWLTDDGPVGAVITVHRNRLVEDGYQQLANLNSSQLRMKIRVQFVNEMGLDEVGIDLDGVFKEFLEETLHRVFDPSLNLFRVTSDQRLYPSPSSHV-QDNHLMLFEFLGKMLAKAIYEGIVVDVPFANFFLTQLLGREKAGCYSFLDELATLDKELYKSLSYIKHYDGDVADLEFTYSYAEDSLGQMVVHDLCPGGRYITVTNDLKISYVHRVAHFRMYKQIRAQTASFIRGFYSILNPDWLAMFSPPELQKLISGDSISVNIEDLKQNTRYSGGFHSNHRVIKWLWDILRRDFSDAERGLFLKFVTSCSRPPLLGFANLEPPFCIRCVQYTNEDQDVGDTLGSVLKGFFGVGGRREEISRLPTTSTCFNLLKLPNYSSRSVLRDKLRYAIHSHAGFEL 1129

HSP 2 Score: 172.17 bits (435), Expect = 1.480e-39
Identity = 122/408 (29.90%), Postives = 216/408 (52.94%), Query Frame = 3 
Query:  171 VPSFLEKTKKE--RETRRLEGVRQKSAIIIQRYYRGFIIRKNL-VKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDK 1385
            VPSF    +K   R T RL    Q+     Q  YRG ++   L V+ +R  F +   ++ + +   E     +  R    LR    I   +  +E L R ++++I+++K   S++++ L+K ++++WI ++ WI       L  ++P      R +++ L+ ++ +   S W    +  +  L   + ++   L   M++  + + +  LL KG+ R T   +  SL G+ TL +R        ++ L  F   IL+VP L+ H+  M+NE + +I+++RLC+K+IL  H+  +    + S +   Y LC IAN+I L LLE +V+A H SEFC VLS L+  L+  +    S+ S +H I GW    +D ++QS+M+ +  QL+LLW+++M+R +F +LY Q  LD+
Sbjct:   21 VPSFHAARRKHECRSTARLLRPGQE-----QLRYRGRVLTTGLPVRLLRQMFEK---VHPEHTTFIETKRKERDERREARLREQAAICIQR--FELLIRHIMSTIETAKPDISFLALALRKATLLDWISVTKWIFVYTLHYLSELDPCTPSGSRLLSLFLSFLLVVTDYSCW----SFYDEKLKSSMQQLNAVLLDHMIQYQLYEKLHLLLCKGLARHTPAFTSTSLTGLFTLAVRPLLYSNFNKSKLIIFTSQILTVPGLILHVSSMMNESYDIIVKERLCSKVILLYHNHAEELELLVSSVEGPYVLCFIANLIQLSLLEEEVIALHCSEFCVVLSKLMRHLSNYVGSKKSNLSSWHPILGWFAQPLDNSLQSAMLFVTKQLRLLWNNRMVRLLFGDLYAQTELDE 414
[Close]
BLAST of HECT domain-containing protein vs. TrEMBL
Match: A0A4S2MAH8 (HECT domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_001505 PE=4 SV=1)

HSP 1 Score: 741.11 bits (1912), Expect = 0.000e+0
Identity = 373/636 (58.65%), Postives = 469/636 (73.74%), Query Frame = 3 
Query: 1566 VCMLYFFTTSSLSQIRDDILAGVSLTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVE--RAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSR-NWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            VCMLY F   SL +I++DILAG+SL DL  R+WRLI   GSV  W  I+ DS+  W+ +PH SHL+HIF   A NL  ILDD E+F+  K F+V EL  M  FFNHL  E V +     +L     T   D    +A+ S   L  T     LFS C  LL ++ ER+ R+ FT   FWL S+ + S  +ADL+K K  A FLLK VPHII HKERV+LF ++++ DKASLG+ +R NW  DD P+GAVI+V R R+VEDGY QL  +N+   + KIRV+F+NE+G+DEVGIDLDGVFKEFLEETL  + +PSLNLF  TSD RLYPSP S + + NHL+LF++LG+M+AKAIYE I+++ PFANFFLTQ+L +E++  YSF+DEL TLDK+LYKSL+Y+KHYDGDV+DLE T+SY ED LG++  HDL PGGRYITVTND KISYVH VA FRM++QIR QT +F  GFYSI+  DW  MFS PE+ KLI GD+  ++++DLKQN RYSGGFH+ HRVI WLWDIL+ +FS+ E+ LFLKFVTSCS+PPLLGFA LEP F IRCV  ++EDQ+  DT+GS+LK  F +  ++ +I RLP+ +TCFNLLKLPNY S+S LR+KLRY I+S AGFEL
Sbjct:  482 VCMLYCFNVGSLREIKNDILAGLSLGDLLPRLWRLIARCGSVVDWVKILTDSNPVWHLEPHASHLMHIFTAAASNLLSILDDVELFQLNKSFSVDELCSMGTFFNHLVYETVTAVPDPWKLCSGSGTNAKDASTTKAECSPSPLSVTT-FPDLFSMCLRLLSIIHERDSRYQFTPANFWLLSNLRISTLLADLRKPKPHALFLLKNVPHIIPHKERVLLFRDRVRDDKASLGVQTRMNWLTDDGPVGAVITVHRNRLVEDGYQQLANLNSSQLRMKIRVQFVNEMGLDEVGIDLDGVFKEFLEETLHRVFDPSLNLFRVTSDQRLYPSPSSHV-QDNHLMLFEFLGKMLAKAIYEGIVVDVPFANFFLTQLLGREKAGCYSFLDELATLDKELYKSLSYIKHYDGDVADLEFTYSYAEDSLGQMVVHDLCPGGRYITVTNDLKISYVHRVAHFRMYKQIRAQTASFIRGFYSILNPDWLAMFSPPELQKLISGDSISVNIEDLKQNTRYSGGFHSNHRVIKWLWDILRRDFSDAERGLFLKFVTSCSRPPLLGFANLEPPFCIRCVQYTNEDQDVGDTLGSVLKGFFGVGGRREEISRLPTTSTCFNLLKLPNYSSRSVLRDKLRYAIHSHAGFEL 1115

HSP 2 Score: 225.328 bits (573), Expect = 3.381e-56
Identity = 135/413 (32.69%), Postives = 235/413 (56.90%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDK 1385
            M+  +  E  +F+E  +KER+ RR   +R+++AI IQR +RGF  RK ++ + R +F QCL  ++          V +L+RAIK L + F    DK+ +E L R ++++I+++K   S++++ L+K ++++WI ++ WI       L  ++P      R +++ L+ ++ +   S W    +  +  L   + ++   L   M++  + + +  LL KG+ R T   +  SL G+ TL +R        ++ L  F   IL+VP L+ H+  M+NE + +I+++RLC+KIIL  H+  +    + S +   Y LC IAN+I L LLE +V+A H SEFC VLS L+  L+  +    S+ S +H I GW    +D ++QS+M  +  QL+LLW+++M+R +F +LY Q  LD+
Sbjct:    1 MFEKVHPEHTTFIETKRKERDERREARLREQAAICIQRNWRGFRDRKLVLHRFRTQFDQCLVPDS---------AVVELLRAIKYLLFKFSPQHDKQRFELLIRHIMSTIETAKPDISFLALALRKATLLDWISVTKWIFVYTLHYLSELDPCTPSGSRLLSLFLSFLLVVTDYSCW----SFYDEKLKSSMQQLNAVLLDHMIQYQLYEKLHLLLCKGLARHTPAFTSTSLTGLFTLAVRPLLYSDFDKSKLIVFTSQILTVPGLILHVSSMMNESYDVIVKERLCSKIILLYHNHAEELELLVSSVEGPYVLCFIANLIQLSLLEEEVIALHCSEFCVVLSKLMRHLSNYVGSKKSNLSSWHPILGWFAQPLDNSLQSAMPFVTKQLRLLWNNRMVRLLFGDLYAQTELDE 400
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Cavefish
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:111196222])

HSP 1 Score: 691.419 bits (1783), Expect = 0.000e+0
Identity = 427/1115 (38.30%), Postives = 642/1115 (57.58%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXX-XXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTN------EXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+   ++    FL+K +  RE R+    ++++A  IQ   R F+ R  L ++IR+E  +        + K   + + K+ R    L + F    DK  +E LCR +L+S+D        Y+S+ L KD  + W++    +L+ +C+ L  ++P +  + + + + LT++      S WKIV     + L   L++I + +   + +      ++ LL  G+ R    LS+ +L  I TL LR       ++  L  F+I+I+SVPA++ H++ +  +    I    L  K IL L S  +    I   L  S++LC++ N+I LG L + VL      F   L+ +L    + +++  S+ +H+H + GW   ++D  +  SM  +  QL+ LW   +I ++F ++  + +  +    +        +           LP    F  K  F   AS  N       +   S     + SVC+LY    ++L+QIR  IL G++ L DL  ++W  I   G        ++  ++       +  +L +F   +R+L  ILDD EV+E++  F + EL+ ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  FT D  WL    KPS    +L+K K  A+ LL+Y+PH+I HK RV+LF   +  +K +LGL+  +     SP    I++RR RM+EDGYDQL ++  +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + NP+LNLF TTS N RLYPSP S ++E NHL LF+++G+M+ KA+YE I+++ PFA+FFL+QVL    S+ YS IDEL +LD + YK+LT +K YDGDVSDL LT SYDED +G++  H+L PGG+ + VTN+ KISY+H++A FRM  QI++QT AF  GF SII  +W  MFS PE+ +LI GD   ID+DDLK++  Y GGFH+ HRVI+WLWDIL ++F+ +E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +KK    RLP+++TCFNLLKLPNY  KS LR+KLRY I+   GFEL
Sbjct:    1 MFGATQTSKSQFLDKARLAREERKGHKEKERAATEIQALIRRFLCRCRLQREIREEVDEFFAATETGTTKRNALSIFKITRK---LLFIFG-KEDKLRFEKLCRIILSSMDVENEPKVWYVSLALSKDLTIPWLKQIKDVLWVSCEFLKKLKPDILQENKLVTLYLTMLGTFTDTSTWKIVRGKGEA-LKPALNRICENIMGHLNQKGFYSVLQILLTNGLARSRPSLSKGTLTAIFTLALRPVVAAHFSDNLLRSFLIHIMSVPAVISHLNTLTPDCMITIQTHDLMRKFILFL-SREEQCSDICVCLEGSHTLCLLGNLIQLGYLNVKVLEQEAGHFVKDLTDMLSYCQRYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLVTRQLQCLWGVPVICTLFCDVLSKKLEVQEPAPAPPPQPNTLQN---------NLPVKNLF--KRAFQKSASVRNILKPVGGRRVDSAEVQKVCSVCVLYQTALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLNNDTDESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKMEELITISSFLNTFVYKMIWDGI---------------LENAK--GEKLE-------LFHSVHGWLMVLYERDCRRRFTPDEHWLRKDLKPSLLFQELEKGKKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKETLGLVETS---SASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPTSNIHE-NHLQLFEFVGKMLGKALYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVSDLGLTLSYDEDVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTGAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYGGFHSSHRVIIWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFEL 1068
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Cavefish
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:111196222])

HSP 1 Score: 691.419 bits (1783), Expect = 0.000e+0
Identity = 427/1115 (38.30%), Postives = 642/1115 (57.58%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXX-XXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTN------EXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+   ++    FL+K +  RE R+    ++++A  IQ   R F+ R  L ++IR+E  +        + K   + + K+ R    L + F    DK  +E LCR +L+S+D        Y+S+ L KD  + W++    +L+ +C+ L  ++P +  + + + + LT++      S WKIV     + L   L++I + +   + +      ++ LL  G+ R    LS+ +L  I TL LR       ++  L  F+I+I+SVPA++ H++ +  +    I    L  K IL L S  +    I   L  S++LC++ N+I LG L + VL      F   L+ +L    + +++  S+ +H+H + GW   ++D  +  SM  +  QL+ LW   +I ++F ++  + +  +    +        +           LP    F  K  F   AS  N       +   S     + SVC+LY    ++L+QIR  IL G++ L DL  ++W  I   G        ++  ++       +  +L +F   +R+L  ILDD EV+E++  F + EL+ ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  FT D  WL    KPS    +L+K K  A+ LL+Y+PH+I HK RV+LF   +  +K +LGL+  +     SP    I++RR RM+EDGYDQL ++  +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + NP+LNLF TTS N RLYPSP S ++E NHL LF+++G+M+ KA+YE I+++ PFA+FFL+QVL    S+ YS IDEL +LD + YK+LT +K YDGDVSDL LT SYDED +G++  H+L PGG+ + VTN+ KISY+H++A FRM  QI++QT AF  GF SII  +W  MFS PE+ +LI GD   ID+DDLK++  Y GGFH+ HRVI+WLWDIL ++F+ +E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +KK    RLP+++TCFNLLKLPNY  KS LR+KLRY I+   GFEL
Sbjct:    1 MFGATQTSKSQFLDKARLAREERKGHKEKERAATEIQALIRRFLCRCRLQREIREEVDEFFAATETGTTKRNALSIFKITRK---LLFIFG-KEDKLRFEKLCRIILSSMDVENEPKVWYVSLALSKDLTIPWLKQIKDVLWVSCEFLKKLKPDILQENKLVTLYLTMLGTFTDTSTWKIVRGKGEA-LKPALNRICENIMGHLNQKGFYSVLQILLTNGLARSRPSLSKGTLTAIFTLALRPVVAAHFSDNLLRSFLIHIMSVPAVISHLNTLTPDCMITIQTHDLMRKFILFL-SREEQCSDICVCLEGSHTLCLLGNLIQLGYLNVKVLEQEAGHFVKDLTDMLSYCQRYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLVTRQLQCLWGVPVICTLFCDVLSKKLEVQEPAPAPPPQPNTLQN---------NLPVKNLF--KRAFQKSASVRNILKPVGGRRVDSAEVQKVCSVCVLYQTALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLNNDTDESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKMEELITISSFLNTFVYKMIWDGI---------------LENAK--GEKLE-------LFHSVHGWLMVLYERDCRRRFTPDEHWLRKDLKPSLLFQELEKGKKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKETLGLVETS---SASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPTSNIHE-NHLQLFEFVGKMLGKALYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVSDLGLTLSYDEDVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTGAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYGGFHSSHRVIIWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFEL 1068
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Cavefish
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:111196222])

HSP 1 Score: 661.759 bits (1706), Expect = 0.000e+0
Identity = 394/993 (39.68%), Postives = 584/993 (58.81%), Query Frame = 3 
Query:  510 MVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTN------EXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            + L KD  + W++    +L+ +C+ L  ++P +  + + + + LT++      S WKIV     + L   L++I + +   + +      ++ LL  G+ R    LS+ +L  I TL LR       ++  L  F+I+I+SVPA++ H++ +  +    I    L  K IL L S  +    I   L  S++LC++ N+I LG L + VL      F   L+ +L    + +++  S+ +H+H + GW   ++D  +  SM  +  QL+ LW   +I ++F ++  + +  +    +        +           LP    F  K  F   AS  N       +   S     + SVC+LY    ++L+QIR  IL G++ L DL  ++W  I   G        ++  ++       +  +L +F   +R+L  ILDD EV+E++  F + EL+ ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  FT D  WL    KPS    +L+K K  A+ LL+Y+PH+I HK RV+LF   +  +K +LGL+  +     SP    I++RR RM+EDGYDQL ++  +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + NP+LNLF TTS N RLYPSP S ++E NHL LF+++G+M+ KA+YE I+++ PFA+FFL+QVL    S+ YS IDEL +LD + YK+LT +K YDGDVSDL LT SYDED +G++  H+L PGG+ + VTN+ KISY+H++A FRM  QI++QT AF  GF SII  +W  MFS PE+ +LI GD   ID+DDLK++  Y GGFH+ HRVI+WLWDIL ++F+ +E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ KK+    RLP+++TCFNLLKLPNY  KS LR+KLRY I+   GFEL
Sbjct:   14 LALSKDLTIPWLKQIKDVLWVSCEFLKKLKPDILQENKLVTLYLTMLGTFTDTSTWKIVRGKGEA-LKPALNRICENIMGHLNQKGFYSVLQILLTNGLARSRPSLSKGTLTAIFTLALRPVVAAHFSDNLLRSFLIHIMSVPAVISHLNTLTPDCMITIQTHDLMRKFILFL-SREEQCSDICVCLEGSHTLCLLGNLIQLGYLNVKVLEQEAGHFVKDLTDMLSYCQRYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLVTRQLQCLWGVPVICTLFCDVLSKKLEVQEPAPAPPPQPNTLQN---------NLPVKNLF--KRAFQKSASVRNILKPVGGRRVDSAEVQKVCSVCVLYQTALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLKLFLECLNNDTDESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKMEELITISSFLNTFVYKMIWDGI---------------LENAK--GEKLE-------LFHSVHGWLMVLYERDCRRRFTPDEHWLRKDLKPSLLFQELEKGKKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKETLGLVETS---SASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGNERLYPSPTSNIHE-NHLQLFEFVGKMLGKALYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVSDLGLTLSYDEDVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRMHTQIKEQTGAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYGGFHSSHRVIIWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTIRKKEPG-GRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFEL 963
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Cavefish
Match: ube3c (ubiquitin protein ligase E3C [Source:NCBI gene;Acc:103025647])

HSP 1 Score: 303.908 bits (777), Expect = 5.334e-86
Identity = 192/522 (36.78%), Postives = 287/522 (54.98%), Query Frame = 3 
Query: 2016 LFSSCYNLLMVLFERNIRHPFTNDRFWLS-----------------SSH----------KPSQFMADL---------KKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPI--GAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSG-LYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            LF    NL+ +L  R+IR PF     WLS                 + H           P Q   D+          +E+ +A  +L  +P ++  +ERV +F   I ADK  +          D P   G  +++RR  + ED YD+L   N  D KK+IRV  +N  G+DE GID  G+F+EFL E LK+  NP+   F TT++  L+PSP +  L  ++    + +LGR++ KA+YE +L+E PFA+FFL+++L    ++    I  L +LD ++Y++L ++K Y+GDV DL L F+   + LG+ +  +L+PGG+ I VT   +I+Y+H+VA +R+ +QIR    AF+ G  +++  +W  MF   E+  LI G    I +DDLK+   YSGG+ A H VI   WD+++N FS++EK   LKFVTSCS+PPLLGF  L P+F   C+H+                         ND++RLP+A+TC NLLKLP +  +  ++ KL Y I S +GFEL
Sbjct:  550 LFKVITNLVKMLKARDIRRPFCPGGHWLSEEVNIRADKVTQLYVPSARHVWRSRRMGRIGPLQSTLDVGLEPPPLSVSEERHLA--ILTELPFVVPFEERVKIFQRLIYADKRDV--------QGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLSELLKSGFNPNQGFFRTTNEGLLFPSPTAEMLIGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLL---GTSADVDIHHLASLDPEMYRNLLFMKSYEGDVEDLGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAHVPICLDDLKKFTNYSGGYSATHPVIKIFWDVVEN-FSDDEKRKLLKFVTSCSRPPLLGFKELYPAF---CIHNGG-----------------------NDLERLPTASTCMNLLKLPEFCDEQLMKSKLLYAIESSSGFEL 1031
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Cavefish
Match: ube3c (ubiquitin protein ligase E3C [Source:NCBI gene;Acc:103025647])

HSP 1 Score: 303.908 bits (777), Expect = 9.293e-86
Identity = 192/522 (36.78%), Postives = 287/522 (54.98%), Query Frame = 3 
Query: 2016 LFSSCYNLLMVLFERNIRHPFTNDRFWLS-----------------SSH----------KPSQFMADL---------KKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPI--GAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSG-LYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            LF    NL+ +L  R+IR PF     WLS                 + H           P Q   D+          +E+ +A  +L  +P ++  +ERV +F   I ADK  +          D P   G  +++RR  + ED YD+L   N  D KK+IRV  +N  G+DE GID  G+F+EFL E LK+  NP+   F TT++  L+PSP +  L  ++    + +LGR++ KA+YE +L+E PFA+FFL+++L    ++    I  L +LD ++Y++L ++K Y+GDV DL L F+   + LG+ +  +L+PGG+ I VT   +I+Y+H+VA +R+ +QIR    AF+ G  +++  +W  MF   E+  LI G    I +DDLK+   YSGG+ A H VI   WD+++N FS++EK   LKFVTSCS+PPLLGF  L P+F   C+H+                         ND++RLP+A+TC NLLKLP +  +  ++ KL Y I S +GFEL
Sbjct:  599 LFKVITNLVKMLKARDIRRPFCPGGHWLSEEVNIRADKVTQLYVPSARHVWRSRRMGRIGPLQSTLDVGLEPPPLSVSEERHLA--ILTELPFVVPFEERVKIFQRLIYADKRDV--------QGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLSELLKSGFNPNQGFFRTTNEGLLFPSPTAEMLIGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLL---GTSADVDIHHLASLDPEMYRNLLFMKSYEGDVEDLGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAHVPICLDDLKKFTNYSGGYSATHPVIKIFWDVVEN-FSDDEKRKLLKFVTSCSRPPLLGFKELYPAF---CIHNGG-----------------------NDLERLPTASTCMNLLKLPEFCDEQLMKSKLLYAIESSSGFEL 1080
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Sea Lamprey
Match: ube3b (ubiquitin protein ligase E3B [Source:ZFIN;Acc:ZDB-GENE-060526-231])

HSP 1 Score: 642.884 bits (1657), Expect = 0.000e+0
Identity = 400/1086 (36.83%), Postives = 616/1086 (56.72%), Query Frame = 3 
Query:  231 RQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXX-XXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSR-----NWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLF-CTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            R+++AI IQ   RGF+ R+ + ++ R E  +          K   + + K+ +    L + F    D K +E  CR LL+S++    S   Y+S+ L KD ++ WI+    +L   C  L  ++P    D +Q+ + LT+++       W++V    ++     ++ I   +   + +  +   ++ L+  G+ R    L++ +L  + T+ LR     + +E  L  F +++LSVPALV H+  +  E   M+    L  K++  L      Q  I   L  + SLC++ N+I L LL   +L      F ++++S+L    + + +  S+ +H+H + GW   SMD  +  +M  +  QL+ LW  +MIR +F ++  + + +      + +          P+  + R     +F +             +   S     +  VC+LY    ++L+QIR  IL G++ L DL  ++W  I   G     A  ++   S       +  +L +F   +R+L  ILDD E++E++  F + ELV ++ F N    +++     E+E                          + S LF+S ++ LM L+ER+ R  F  +  WL    K +   ++L+K K  AK LL+++PH++ HK+RVVLF   +  +K+SL   ++     + NH  +PI   I+VRR RM+EDGY+QL ++  +  K  IRV+FIN+LGMDE GID DGVFKEFLEE +K + +P LNLF  T  D RLYPSP S ++E NHL L +++G+M+ KA+YE I+++ PFA FFL+QV     S  YS IDEL +LD + YK+LT +K YDGDVS+L LTFSY+ED +GK+  ++L PGG+   VTN+ KISY+H++A  RM+ +I+ QT AF  GF S+I  +W  MFS PEM +LI GDTG ID +DL+++  Y GGFH  HRVI+WLWDIL  EF+  E+++FLKFVTSCS+PPLLGFA+L+PSFSIRCV  +D DQ+  DT+GS+L+  FT+ +KK    RLP+++TCFNLLKLPNY  KS LR+KLRY ++   GFEL
Sbjct:   32 RERAAIKIQALVRGFLCRRCIARRTRHEVDEFFSAQEASPAKKNALCLFKIGQK---LLFIFNTAEDIKRFEKFCRHLLSSMEEDNDSKVWYVSLALSKDYMLRWIKQLKDVLSICCSYLKKLKPESILDTKQITLFLTVLVTFTDAGGWRMVRVKGDT-FKISMNLICANVMGHLNQKGLYPDLQILMTNGLARVVPTLNKATLTAVFTVALRPVVAAKFSENLLRSFTLHVLSVPALVLHLSNIAPECLNMMSGHDLFRKVLTFLRQK-DYQEDICICLEGTMSLCLLGNLIMLALLNESLLEEETEAFSSLVTSVLTYCQKYVLQKKSNLTHWHPVLGWFAQSMDYGLNEAMPAVTKQLQSLWGIRMIRVLFRDVLTRKLAEGQEPALATAPPTAAVPNDKPVKSMFR----KAFRRSAAVRSILRPVGGKRVDSPEVQRVCGVCVLYQTALTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPQGGLALFLECLSSDTEDSRCLLAMLTLFCDCSRHLITILDDIELYEEQVSFKLEELVTISSFLNTFVFKMIWDGILESE------------------------KTDRSQLFASVHSWLMTLYERDCRRRFAPEDHWLKKDLKANVLFSELEKGKKRAKLLLQHIPHVLPHKDRVVLFRSMVAKEKSSLVTGNQIVSLMDLNHG-APITH-ITVRRSRMLEDGYEQLSRLPPNSLKGTIRVKFINDLGMDEAGIDQDGVFKEFLEEIIKKVFDPELNLFKITIGDERLYPSPTSYVHE-NHLQLMEFVGKMLGKAVYEGIVVDVPFAPFFLSQVRGVHTSMPYSSIDELPSLDAEFYKNLTSIKRYDGDVSELGLTFSYEEDIMGKLVCYELCPGGKTTLVTNENKISYIHMLAHHRMYVKIKKQTGAFIHGFKSLISPEWMGMFSTPEMQRLIAGDTGEIDFEDLRKHTVYYGGFHNNHRVIIWLWDILTKEFTAQERAMFLKFVTSCSRPPLLGFAHLKPSFSIRCVEVAD-DQDTGDTLGSVLRGFFTI-RKKEPAGRLPTSSTCFNLLKLPNYSKKSVLRDKLRYAVSMNTGFEL 1079
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Sea Lamprey
Match: ube3c (ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-GENE-040426-1211])

HSP 1 Score: 290.041 bits (741), Expect = 9.665e-82
Identity = 185/524 (35.31%), Postives = 275/524 (52.48%), Query Frame = 3 
Query: 2010 STLFSSCYNLLMVLFERNIRHPFTNDRFWLSSS-----------HKPSQFMA-------------------------DLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSP--IGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLL-FQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            + LF    NL+ +L  R+ R PF     WLS             ++P+                              + +E+ +A  +L  +P ++  +ERV +F   I +DK          +  DSP  +G  +++RR  + ED YD+L   N  D +++IRV  +N  G+DE GID  G+F+EFL E LKT  NP    F TT+   LYP+P + L   +     + +LGRM+ KA+YE +L+E PFA FFL+++L          I  L +LD ++Y++L ++K Y GDV +L L F+   + LG+ +  +L+ GG+ I VT+  +I+Y+H+VA +R+ +QIR    AF+ G  ++I  +W  MF   E+  L+ G    ID+ DLK    YSGG+ A H VI   W +++  F++ +K   LKFVTSCS+PPLLGF  L P+F   CVH+   D E                       RLP+A+TC NLLKLP +  + T+  KL Y I S AGFEL
Sbjct:  607 TQLFKVISNLVKMLKARDTRRPFCPSNHWLSPEVSIRADRVPQLYRPAARHVWRNRRIRGIGPLYSSLDVGDEGPPLSVSEERQLA--ILTELPFVVPFQERVKIFQRLISSDKEE--------SQGDSPFFVGINVTIRRPYIYEDAYDKLSPENEPDLRRRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKTGFNPHQGFFRTTNQGLLYPNPEARLLVGDGFTRHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTTGD---VDIHHLASLDPEVYRNLLFLKSYQGDVEELGLNFTVVNNELGEAQVVELKAGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLATVINLEWLRMFDEQELQVLLSGAQVPIDLQDLKNFTNYSGGYTADHPVIKVFWHVVEG-FTDEQKRKLLKFVTSCSRPPLLGFKELFPAF---CVHNGGADPE-----------------------RLPTASTCMNLLKLPEFLEEETMHGKLLYAIESAAGFEL 1090
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Sea Lamprey
Match: nedd4a (NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;Acc:ZDB-GENE-051005-2])

HSP 1 Score: 170.244 bits (430), Expect = 2.755e-45
Identity = 131/434 (30.18%), Postives = 210/434 (48.39%), Query Frame = 3 
Query: 2178 VPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDF-KKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLF--CTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETH--DLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSL-FLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFE 3461
            VP+   +K++   F +K+K                D P    + + R  ++ED Y +++ V   D  K ++ + F  E      G+D  GV +E+     K + NP   LF    T +  L  +P+SGL  + HL  F ++GR+   A++   L++  F   F   +L K  +     ++++ ++D + Y SL ++   + D +DL+L F  DE+  G+ +TH  +L+P G  I VTN+ K  Y+ +V ++R  ++++ Q  AF  GF  +I  D   +F   E+  L+CG  G +DV+D +Q+  Y   + A H VI W W  +     + EK +  L+FVT  S+ P+ GFA L                      GS    +FT+       ++LP A TCFN L LP YES   LREKL   I +  GFE
Sbjct:  109 VPYSRDYKQKYDFFRKKLKKPA-------------DIPNRFEMKLHRASILEDSYRRIVAVKRADLLKARLWIEFDGE-----KGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPISGLCNEEHLSYFTFIGRVAGMAVFHGKLLDGFFIRPFYKMMLQKPIT-----LNDMESVDSEYYNSLMWI--LENDPADLDLRFCIDEEMFGQ-QTHLVELKPNGSEILVTNENKKEYIELVIQWRFVERVQKQINAFMEGFSELIPMDLIKIFDENELELLMCG-LGDVDVNDWRQHTIYKNSYCANHPVIQWFWKAVL--LMDGEKRIRLLQFVTGTSRVPMNGFAEL---------------------YGSNGPQLFTIEMWSTS-EKLPRAHTCFNRLDLPPYESFDDLREKLNIAIENAQGFE 491
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Sea Lamprey
Match: ube3a (ubiquitin protein ligase E3A [Source:ZFIN;Acc:ZDB-GENE-041114-190])

HSP 1 Score: 140.198 bits (352), Expect = 5.776e-34
Identity = 114/390 (29.23%), Postives = 177/390 (45.38%), Query Frame = 3 
Query: 2304 ISVRRQRMVEDGYDQLMKV---NTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSD-LELTFSYDE-DRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            + VRR  +++D   +L  +   N  D KK++ V F  E G+DE      GV KEF +  ++ L NP + +F      RL+    S L  +     F  +G ++  AIY   +++  F      +++ K  +       +L      LY+SL  +  Y+G V D +  TF     D  G   T DL+  G  I VTND K  +V + A + + Q +  Q +AF+ GF+ +           PE ++L+   + ++D   L+    Y GGF+   RVI   WD + ++F E++K LFL+F T   + P                            VG L K    ++K   D  RLP+A TCFN+L LP Y S+  L+E+L   I    GF
Sbjct:  517 LKVRRDHVIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDE-----GGVSKEFFQLVVEELFNPDIGMFTFDESTRLFWFNPSSLENEGQ---FTLIGIVLGLAIYNNCILDIHFPMVVYRKLMGKRGT-----FHDLADSHPALYQSLKDLLAYEGSVEDDIMATFRISYFDMFGTPITQDLKENGEDIPVTNDNKKEFVDLYAEYILNQSVEKQFKAFRRGFHMVTSESPLKALFRPEEVELLVCGSRVLDFHALEDATEYDGGFNKSSRVIRDFWDTV-HDFCEDKKRLFLQFTTGTDRAP----------------------------VGGLGKLKMIIAKNGPDSDRLPTAHTCFNVLLLPEYSSREKLKERLLKAITHAKGF 864
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Sea Lamprey
Match: wwp2 (WW domain containing E3 ubiquitin protein ligase 2 [Source:ZFIN;Acc:ZDB-GENE-000607-82])

HSP 1 Score: 140.198 bits (352), Expect = 7.125e-34
Identity = 93/299 (31.10%), Postives = 153/299 (51.17%), Query Frame = 3 
Query: 2565 NHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSL-FLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            +HL  F+++GR +A A+Y    I+  F+  F  ++L+K+ +     I +L ++D + Y SL +++  + +   LE+ FS D + LGK+ +HDL+P G  I VT + K  Y+ ++  +R  + + +QT+AF  GF  ++   W   F   E+  ++CG    ID+ D +++  Y   ++   + I W W ++K    +NEK L  L+FVT   + P+ GFA L                     +GS     F + K   +   LP + TCFN L LP Y+S   L+EKL Y I    GF
Sbjct:  662 DHLAYFRFIGRFIAMALYHGKFIDTGFSLPFYKRMLNKKLT-----IKDLESIDPEFYNSLIWLRDNNIEECGLEMFFSVDMELLGKVSSHDLKPDGSDILVTEENKEEYIGLMTEWRFSRGVEEQTKAFLDGFSEVVPLQWLLYFDERELEVMLCG-MQEIDLADWQRSTIYR-HYNRSSKQISWFWQVVKE--MDNEKRLRLLQFVTGTCRLPVGGFAEL---------------------IGSNGPQKFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGF 929
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Yeast
Match: HUL5 (Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock [Source:SGD;Acc:S000003109])

HSP 1 Score: 206.068 bits (523), Expect = 5.161e-55
Identity = 156/439 (35.54%), Postives = 218/439 (49.66%), Query Frame = 3 
Query: 2178 VPHIIAHKERVVLFHEKIKADKASLGL--------LSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXX-XNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGD-VSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            +P  I  +ERV LF+  I  DK  L L        +   W        + I + R  ++ED ++    +  + FK  + V FINE G +E GID  G+ KEFL         +P   LF T     LYPS    +Y+   L    +LG+++ K +YE +LI+  FA+FFL ++L+     + SF D L + D  LY +L  + +   D +  L+LTF  DE      +  DL P G    VT D  + YV  V  +++ ++      AF  G   II   W +MF+  E+  LI G+   ID+DDLK N  Y GG+    + IV  W++L NEF   EK  FLKFVTS  + PL GF  L+P F IR   +                          +  RLP+A+TC NLLKLP+Y +K+ LREKL Y INSGA F+L
Sbjct:  507 LPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTGMRKQSAI-ISRDNVLEDAFNAFNSIG-ERFKASLDVTFINEFG-EEAGIDGGGITKEFLTTVSDEGFKDPKHELFRTNDRYELYPS---VVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSD-LGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPE-SSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEY-GGYKEEDQTIVDFWEVL-NEFKFEEKLNFLKFVTSVPQAPLQGFKALDPKFGIRNAGT--------------------------EKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDL 909
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Yeast
Match: RSP5 (NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome [Source:SGD;Acc:S000000927])

HSP 1 Score: 156.377 bits (394), Expect = 2.075e-39
Identity = 113/392 (28.83%), Postives = 199/392 (50.77%), Query Frame = 3 
Query: 2289 PIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            P    I VRR+ + ED Y ++M+   +D KK++ ++F  E G+D       GV +EF       + NP   LF  ++ DN  +  +P SG+  + HL  F+++GR++   ++    ++A F       +L K+       + ++  +D ++Y SL ++     D   L+LTFS D++R G++ T DL+P GR I VT+  K  YV +  ++R+  ++++Q +AF  GF  +I  D   +F   E L+L+ G    ID++D K++  Y  G+     VI W W  + +E+   +++  L+F T  S+ P+ GF                     +D  GS     FT+ +K  ++++LP + TCFN + LP Y    ++++KL   +    GF
Sbjct:  452 PGQCHIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLD-----YGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPE-HLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKK-----VVLQDMEGVDAEVYNSLNWMLENSID-GVLDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERE-LELLIGGIAEIDIEDWKKHTDYR-GYQESDEVIQWFWKCV-SEWDNEQRARLLQFTTGTSRIPVNGF---------------------KDLQGSDGPRRFTI-EKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGF 806
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Yeast
Match: TOM1 (E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase [Source:SGD;Acc:S000002865])

HSP 1 Score: 154.451 bits (389), Expect = 4.427e-38
Identity = 129/438 (29.45%), Postives = 209/438 (47.72%), Query Frame = 3 
Query: 2166 LLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKK-KIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNR--LYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDL-ELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSG-AGFEL 3464
            LL   P ++    +   F+ K+K+D      L              I+VRR+++  D Y  L     D+ K  K+ + F       E G+D  GV +E+ +   + + NP   LF     ++   +P+  SG+  + HL  F+++G ++ KAI ++  ++  F+      +L +  S     + ++ +LD D YKSL ++   + D++D+ E TFS + D  G+ +  +L  GG+ I VT   K  YV  V  +++   +++Q   F +GFY++I +D   +F   E+  LI G    IDVDD K N  Y   + A  + + + W  +++ F   E++  L+FVT  SK PL GF  L                     V  + K  F++ +     +RLPS+ TCFN L LP YES  TLR  L   IN G  GF L
Sbjct: 2880 LLVKNPKVLDFDNKRYFFNAKLKSDNQERPKLP-------------ITVRREQVFLDSYRALFFKTNDEIKNSKLEITF-----KGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINPE-HLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVS-----LKDMESLDPDYYKSLVWI--LENDITDIIEETFSVETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPD-IDVDDWKNNTTYV-NYTATCKEVSYFWRAVRS-FDAEERAKLLQFVTGTSKVPLNGFKELS-------------------GVNGVCK--FSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEGFGL 3267
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Yeast
Match: HUL4 (Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex [Source:SGD;Acc:S000003797])

HSP 1 Score: 89.3521 bits (220), Expect = 1.821e-18
Identity = 114/441 (25.85%), Postives = 184/441 (41.72%), Query Frame = 3 
Query: 2187 IIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNR-----LYPSPLSGLYEQNHLLLFQYL-GRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSY--------DEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSII-QRDWFDMFSVPEMLKLICGD--TGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            I+ ++ R ++ HE   A++A L  L +  + D   +   I VRR  +  D   + +K +  D  K +R+ F+NE      GID  G+ KE+     K+L NP   LF    ++      + P        +N  L   YL G +M  AI+   +++  F    L + L  E  +   + +      ++L K L Y +    DV  L    +Y        D     +  T +L   GR + +T   K  +V     F + + I  Q   F  GF  +  + +   +F+  E+ +L+CGD      D   L+   +Y GGF    R + W W+I+++     +K L L+FVT+  + P  G + +    S+   H SD+                           LP A TCFN + L NY SK  L  KL + IN   G+
Sbjct:  490 IMEYEIRRIMEHE---AEQAFLISLDKGKSVD---VYFKIKVRRDVISHDSL-RCIKEHQGDLLKSLRIEFVNE-----PGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKA-LYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKL-LQFVTASDRIPATGISTIPFKISLLGSHDSDD---------------------------LPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGY 889
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Yeast
Match: UFD4 (Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000001493])

HSP 1 Score: 87.4261 bits (215), Expect = 9.801e-18
Identity = 85/325 (26.15%), Postives = 145/325 (44.62%), Query Frame = 3 
Query: 2529 LYPSPLSGLYEQNHLL-LFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQS-NMYSFIDELNT-------LDKDLYKSLTYVKHYDGD---VSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVD----DLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAG 3455
            L+P PL+       ++ LF YLG  +A+++ +  +++  F+  F  ++LH+  + N+ +   ++ T       +D  L KSL Y+     D   +  L LTF+   +     +  +L PGG   ++ +     Y+H V    + + I  Q +AF  GF  +   +   +    E++ +     G ++ D     L  N+    G+     +I     I+ + F ++E+ LFL+F+T   K P+ GF  L P F++   H+  ED    D                   + LPS  TC N LKLP Y SK  +R +L   I  GAG
Sbjct: 1186 LFPEPLNPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFF-ELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVPGN-----DDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIF----GRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISII-SAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHA--EDGLTAD-------------------EYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAG 1478
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Nematostella
Match: EDO47399 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLV6])

HSP 1 Score: 640.188 bits (1650), Expect = 0.000e+0
Identity = 373/995 (37.49%), Postives = 569/995 (57.19%), Query Frame = 3 
Query:  510 MVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKA----STTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVSLTD-LPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPH-VSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS--DNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKK--KNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            + L +D I+ WI+    +L+  C  +  ++P + +D +++++ L +++     SRWKI+       L   L ++   +   +        +KDLL+ G+ R    L   S   ++TL LR     + +E     FI+N+LSVP LV H+  +  E  + +    +  +++  L  D  +++ I++ L  SY+LC++ +I       + +   + + +  V++ LL+  +  +++  S+ +H+H I GW     +  +   + H+  QL +LW  + ++ +F +L     LD +    S     E       +F        G    KL F + +       +           + +VC++Y     + SQIR D+L G+S  +    R+WR  Q  G+      ++     G  +  H +   L +F     +L  I+DD E++E++K F + +LV M+ F N L  ++     ++                +K  G           L ++ +  LM+L++R+ R  F     WL    +   F+++L+  K  A  +L+ +PH+I HKERV LF + +  DK SLG+   +   D  P G +I+  R R++EDGYDQL  +     K  IRVRFINE G+ E GID DGVFKEFLEET+K   +P+ NLF  T+  + RLYPSP S +++ NHLLL++++G+M+ KA+YE I++E PFA FFL  VL  + SN+YS IDEL +LD++LYKSLT++KHYDGD+ DL+LTFS+DED LGK+ TH L+PGG  I V+++ KISYVH++A +RM  QIR+QTRAF  GF SI+  DW  MFS PE+ +LI GD   +D+ DL+ + RY GG+H GHRV+VWLW+IL  EF++ EKSLFLKFVTSCSKPPLLGF +LEP FSIRCV   D D++  DTVGS+L+    + ++  +  + RLP+A+TCFNLLKLPNY  KSTLR+KLRY I   AGFEL
Sbjct:   13 VALSQDLILLWIQQVKRLLWLCCHFMRKLKPHIVNDAKEISIYLNMLVIFTDCSRWKILTVKGGEALRPSLQQLCSNILGHLNAKGFYPVLKDLLMNGLARFEPALKAASFTAVITLSLRSLVIAQFSENLCSLFILNVLSVPGLVLHLSNIAPEAVKFLQTHNVYRRVLAFLRQDQSSRI-IYNSLECSYALCLLESITSFWWTVLIIRVKNTTVWVAVVTRLLLYCHSYVSKQQSNLTHWHPILGWFKQKSEPRLNDCIPHVTRQLGVLWHRQTVQLLFADLQTVTELDTSAQAQSDKGEHEACLWRDVLF--------GFHLSKLRFWFNSLKLGGNKSSSRVSQSQVELVSNVCVMYQTMIITFSQIRLDVLTGLSYQEEFLVRLWRFFQLIGNDGGPKLVLSSITRGALNCSHSLQATLTLFCDCCSHLLPIVDDGEMYEQQKPFRLDDLVNMSAFLNQLVFKMYWCEVTD---------------ESKPQG------CSGEALLTAAHTFLMILYDRDCRRAFAPPNHWLIKDIRIGSFVSELEVGKQRALLVLRKIPHVIPHKERVRLFRDFVAKDKESLGIARPS--DDFMPQGTLITAHRNRLLEDGYDQLSVLPAHILKGLIRVRFINEQGLPEAGIDQDGVFKEFLEETIKHAFDPAFNLFKVTTGEEQRLYPSPTSFIHD-NHLLLYEFVGKMLGKAVYEGIVVEVPFAFFFLNHVLGNQHSNLYSSIDELPSLDQELYKSLTFIKHYDGDIRDLDLTFSFDEDVLGKVVTHQLKPGGTAIVVSDENKISYVHLMAHYRMCIQIREQTRAFIRGFKSIVHNDWLRMFSAPELQRLISGDNTALDLSDLRVHTRYYGGYHGGHRVVVWLWEILDKEFNDQEKSLFLKFVTSCSKPPLLGFEHLEPPFSIRCVECPD-DEDDGDTVGSVLRGFLNIRRRNARETVSRLPTASTCFNLLKLPNYRKKSTLRDKLRYAIQCNAGFEL 973
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Nematostella
Match: EDO46071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR93])

HSP 1 Score: 174.866 bits (442), Expect = 2.283e-44
Identity = 128/390 (32.82%), Postives = 192/390 (49.23%), Query Frame = 3 
Query: 2304 ISVRRQRMVEDGYD--QLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLF-CTTSDN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFE 3461
            I +RR+ ++ED Y   QL  V  +  K ++ + F  E      G+D  G+ +E+     K + NP   LF  + SDN  L  +P SGL  + HL  F+++GR+   A+Y   L++A F   F   +L +      + ID + ++D + Y SL ++   + D  DL+L F  DE+  G +   DL+P G    VTN+ K  Y+++V ++R   ++ DQ RAF  GF  +I  +   +F   E+  L+CG  G ID  D ++N  Y G +H  H VI W W  + N F    ++  L+FVT  S+ P+ GF+ L                      GS     FT+ +       LP A TCFN L LP Y S   LRE+LR  I +  GFE
Sbjct:  633 IHIRRRNLMEDSYRAVQLSIVKPEILKSRLWIVFDGE-----TGLDYGGLQREWFYLLSKEVFNPYYGLFEYSASDNYTLQINPNSGLCNEEHLSYFKFIGRVAGMAVYHGKLLDAFFIRPFYKMMLGRP----ITLID-MESVDSEYYNSLNWI--LENDPEDLDLHFCVDEELFGILSVKDLKPNGSQTNVTNENKREYINLVIKWRFVSRVEDQMRAFMEGFCDLIPHNLIQIFDERELELLMCG-LGEIDTVDWRKNSNYRGEYHDKHIVIQWFWKAV-NSFDIETRARLLQFVTGTSRVPMNGFSEL---------------------YGSNGPQRFTI-EPWGTPHSLPRAHTCFNRLDLPRYRSYYELRERLRIAIENTQGFE 986
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Nematostella
Match: EDO49327 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHD5])

HSP 1 Score: 162.155 bits (409), Expect = 1.728e-43
Identity = 117/393 (29.77%), Postives = 191/393 (48.60%), Query Frame = 3 
Query: 2289 PIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQN--HLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSL-FLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGF 3458
            P    I+V R  + E+ + Q+M+    D ++++ + F       E G+D  GV +E+       +LNP   LF   + N  Y   ++     N  HL+ F+++GR +A A+Y    I+  F   F  ++L+K+       + +L T+D + Y SL +VK  + +   LE+ F+ D + LGK+ +HDL+PGG  I VT + K  Y+ ++  +R+ + I +QTRAF  G + ++   W   F   E+  ++CG    IDV+D +QN  Y   +    + ++W W  +K    +NEK +  L+FVT   + P+ GF  L                     +G      F + K   +   LP + TCFN L LP Y+S   L EKL + I    GF
Sbjct:    6 PSHIKITVSRTNLFEESFQQVMRYQPHDLRRRLYITF-----KGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYANKNN-YSLQINAASSVNPDHLMYFKFIGRFIAMALYHGKFIDRGFTLPFYKRMLNKK-----LLMKDLETIDPEFYNSLVWVKENNIEECGLEMFFTVDMELLGKVTSHDLKPGGTDIAVTEENKEEYISLMTEWRLNRGIEEQTRAFLEGMHEVLPLYWIQYFDERELELMLCG-MQEIDVEDWQQNTVYR-HYTRNSKQVMWFWQAVKA--YDNEKRIRLLQFVTGTCRLPVGGFTEL---------------------MGDNGPQKFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYEQLVEKLTFAIEETEGF 361
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Nematostella
Match: EDO49383 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG94])

HSP 1 Score: 137.887 bits (346), Expect = 2.337e-35
Identity = 102/351 (29.06%), Postives = 168/351 (47.86%), Query Frame = 3 
Query: 2421 EVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNR--LYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSD-LELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            E G+D  G  +EF     + + NP   LF  ++++   +  SP+S LY  N    F++ GR++   I  + L++A     F T+  +K        + ++  LD   ++S+T+V   + D+ D L+LTFS  E+  G++   +L PGG+ I VT   K  YV  + ++R+ + + +Q  +   GF  +I     ++F   E L+L+   T  ID+ D ++N  Y  G+H  H+V+ W W  + + F   ++   L+FVT  S  P  GFA L                      GS     F++ ++  D  +LP A TCFN L +P Y S   L EKL Y +     F +
Sbjct:   20 EEGLDYGGPAREFFFLISRQIFNPYYGLFEYSANDTYTVQVSPVS-LYVDNSHEWFRFCGRIVGLVIIHQHLLDA-----FFTRTFYKALLRSLCDLSDVEALDALFHQSMTWV--IENDIEDVLDLTFSVSEEIFGQVTERELIPGGKDIAVTEQNKGDYVAEMVKWRVERGVSEQMESIVRGFNEVIDPALVNIFDARE-LELVISGTADIDIKDWRRNTEYRSGYHDNHKVVKWFWKAVSS-FDNEQRLRLLQFVTGTSSIPYEGFAALR---------------------GSTGPRKFSI-ERWGDYTKLPRAHTCFNRLDMPIYRSYDELLEKLTYAVEETGSFAM 338
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Nematostella
Match: EDO40302 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7U7])

HSP 1 Score: 138.272 bits (347), Expect = 1.973e-33
Identity = 106/392 (27.04%), Postives = 173/392 (44.13%), Query Frame = 3 
Query: 2301 VISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNR---LYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSD-LELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            V+ VRR  ++ D   Q+  +   D KK ++++++   G  E+G+D+ G+ KEF    + ++  P   +F    ++R   +       L E      F+ +G ++  AIY  I+++  F      QV++K+       +++L  +   L  SL  +  Y+GDV D    TF       GK+   +L P G  + V N+ +  +VH   ++ +   +  Q  AF  GF+ +       +F   E+  LICG   ++D  DL     Y  G+ A H  I   W++  NE + ++K   L FVT   + PL G + L                             F + K   D  RLP+A TCFN L LP Y S   L+E+L   I +  GF L
Sbjct:  350 VLEVRRDHLIRDTLSQI-HLKEYDLKKPLKIKYV---GGGELGLDMGGLQKEFFHMIVDSIFEPGYGMFTYIEESRTMWINGESFESLKE------FELVGIVLGLAIYNGIILDIHFP-----QVIYKKLQGQTPSLEDLIGVQPSLGNSLKQLLEYEGDVEDTFCYTFQVSAMSYGKVCDRELIPNGAEVPVNNENREEFVHRYVKYLLVDSVAKQFDAFSAGFHKVCGGSALTLFCADELELLICGHH-VLDFSDLVLAASYDDGYSAQHSTIKMFWNVF-NEMTNHQKKALLMFVTGSDRVPLKGLSNL----------------------------TFIIQKHGQDSDRLPTAMTCFNRLLLPEYTSPKRLKERLIVAIENSKGFGL 696
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Medaka
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:101170594])

HSP 1 Score: 699.123 bits (1803), Expect = 0.000e+0
Identity = 426/1113 (38.27%), Postives = 643/1113 (57.77%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXX-XXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXL-IGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLI---QNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+   +S    FL+K ++ RE R+ +  ++K+A  IQ   R F+ R  L K++R E       +   + K   + + K+ R    L + F    DK  +E LCR +L S++        Y+S+ L KD  + W++    +L+  C  L  ++P +  D + + + LT+++     + W+IV     + L   L++I + +   + +      ++ LL  G+ R    LS+ +L  I +L LR       ++  L  F+I+I+SVPA+V H++++  E    +    +  K IL L S  +  + I   L  S++LC++ N+I LG L   VL    + F   L+ +L    + +++  S+ +H+H + GW   ++D  +  SM  +  QL+ LW   +IR++F ++  + +  +         +     L +  +FK        +F K             +   S     + S+C+LY    S+L+QIR  IL G++ L DL  ++W  I      G +K + + + +          +  +L +F   +R+L  ILDD EV+E++  F + EL+ ++ F N    +++                   +E AK  G+ L+       LF S +  LMVL+ER+ R  FT D  WL    KPS    +L+K K  A+ LL+Y+PH+I HK RV+LF   +  +K SLGL+  +     SP    I++RR RM+EDGYDQL ++  +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + NP+LNLF TTS D RLYPSP S ++E NHLLLF+++G+M+ KAIYE I+++ PFA+FFL+QVL    S+ YS IDEL +LD + YK+LT +K YDGDV DL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT AF  GF  II  +W  MFS PE+ +L+ GD   ID+DDLK++  Y GGFH+ HRVI+WLWDIL ++F+  E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ KK+    RLP+++TCFNLLKLPNY  KS LR+KLRY I+   GFEL
Sbjct:    1 MFGVPQSSKSEFLDKARQAREERKGQKEKEKAATQIQALIRRFLCRCRLQKELRKEVDDYFQTSETGATKRNALSIFKIARK---LLFIF-CQEDKMRFEKLCRAILASMEVENEPKVWYVSLALSKDLTIPWLKQIKDVLWVCCQLLKKLKPDILQDNKLITLYLTMLVTFTDTTTWRIVRGKGEA-LKPALTRICENIMGHLNQKGFYSVLQILLTNGLARSKPSLSKGTLTAIFSLSLRPVIAAHFSDNLLRSFLIHIMSVPAIVSHLNVLTPECMTSMQTHDMLRKFILFL-SREEQCLDICVCLEGSHTLCLLGNLIYLGYLNEKVLEEEANHFVKDLTDMLSYCQRYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLVTKQLQHLWGVSVIRTLFSDVLSKKLESQEPTPPPPQPSTSQNNLPVKSLFK-------RAFQKSASVRNILKPVGGKRVDSAEVQKVCSICVLYQTALSTLTQIRLQILTGLTHLDDLLPKLWAFICELGPQGGLKLFMDCLNNDTE---ESKQLLAMLMLFCDCSRHLITILDDIEVYEEQTSFKIEELLTISSFLNTFVYKMIWDGI---------------LENAK--GEKLE-------LFHSVHGWLMVLYERDCRRRFTPDDHWLRKDLKPSVLFQELEKGKRRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKESLGLIETS---SASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGDERLYPSPTSYIHE-NHLLLFEFVGKMLGKAIYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVGDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKEQTAAFIRGFRCIINPEWLHMFSTPEVQRLVSGDNAEIDLDDLKKHTVYYGGFHSSHRVIIWLWDILSSDFNAEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTIRKKEPG-GRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFEL 1067
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Medaka
Match: ube3b (ubiquitin protein ligase E3B [Source:NCBI gene;Acc:101170594])

HSP 1 Score: 635.95 bits (1639), Expect = 0.000e+0
Identity = 402/1109 (36.25%), Postives = 609/1109 (54.91%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXL-IGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVS-LTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTS-DNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            M+   +S    FL+K ++ RE R+ +  ++K+A  IQ   R F+ R  L K++R E       +   + K   + + K+ R    L + F    DK  +E LCR +L S            M ++ +                       +P +  D + + + LT+++     + W+IV     + L   L++I + +   + +      ++ LL  G+ R    LS+ +L  I +L LR       ++  L  F+I+I+SVPA+V H++++  E    +    +  K IL L S  +  + I   L  S++LC++ N+I LG L   VL    + F   L+ +L    + +++  S+ +H+H + GW   ++D  +  SM  +  QL+ LW   +IR++F ++  + +  +         +     L +  +FK        +F K             +   S     + S+C+LY    S+L+QIR  IL G++ L DL  ++W  I   G        +   ++       +  +L +F   +R+L  ILDD EV+E++  F + EL+ ++ F N    +++        L + +S     +ER                        LM+  ++NI                       L+K K  A+ LL+Y+PH+I HK RV+LF   +  +K SLGL+  +     SP    I++RR RM+EDGYDQL ++  +  K  IRV+F+N+LG+DE GID DGVFKEFLEE +K + NP+LNLF TTS D RLYPSP S ++E NHLLLF+++G+M+ KAIYE I+++ PFA+FFL+QVL    S+ YS IDEL +LD + YK+LT +K YDGDV DL LT SYDED +G++  H+L PGG+ I VTN+ KISY+H++A FRM  QI++QT AF  GF  II  +W  MFS PE+ +L+ GD   ID+DDLK++  Y GGFH+ HRVI+WLWDIL ++F+  E+++FLKFVTSCS+PPLLGFAYL+P FSIRCV  SD DQ+  DT+GS+L+  FT+ +KK    RLP+++TCFNLLKLPNY  KS LR+KLRY I+   GFEL
Sbjct:    1 MFGVPQSSKSEFLDKARQAREERKGQKEKEKAATQIQALIRRFLCRCRLQKELRKEVDDYFQTSETGATKRNALSIFKIARK---LLFIF-CQEDKMRFEKLCRAILAS------------MEVENEP----------------------KPDILQDNKLITLYLTMLVTFTDTTTWRIVRGKGEA-LKPALTRICENIMGHLNQKGFYSVLQILLTNGLARSKPSLSKGTLTAIFSLSLRPVIAAHFSDNLLRSFLIHIMSVPAIVSHLNVLTPECMTSMQTHDMLRKFILFL-SREEQCLDICVCLEGSHTLCLLGNLIYLGYLNEKVLEEEANHFVKDLTDMLSYCQRYVSQKKSNLTHWHPVLGWFSQTVDYGLNESMPLVTKQLQHLWGVSVIRTLFSDVLSKKLESQEPTPPPPQPSTSQNNLPVKSLFK-------RAFQKSASVRNILKPVGGKRVDSAEVQKVCSICVLYQTALSTLTQIRLQILTGLTHLDDLLPKLWAFICELGPQGGLKLFMDCLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQTSFKIEELLTISSFLNTFVYKMIWDGI----LGECVSLPSSFIER------------------------LMLWMKKNI----------------------TLEKGKRRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKESLGLIETS---SASPHVTHITIRRSRMLEDGYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGDERLYPSPTSYIHE-NHLLLFEFVGKMLGKAIYEGIVVDVPFASFFLSQVLGHHHSSFYSSIDELPSLDSEFYKNLTSIKRYDGDVGDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKEQTAAFIRGFRCIINPEWLHMFSTPEVQRLVSGDNAEIDLDDLKKHTVYYGGFHSSHRVIIWLWDILSSDFNAEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD-DQDTGDTLGSVLRGFFTI-RKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGFEL 1006
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Medaka
Match: ube3c (ubiquitin protein ligase E3C [Source:NCBI gene;Acc:101155064])

HSP 1 Score: 293.508 bits (750), Expect = 3.116e-82
Identity = 207/662 (31.27%), Postives = 336/662 (50.76%), Query Frame = 3 
Query: 1659 MWRLIQN------SGSVKQWANII-KDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEK---------VFTVGELVEMADFFNHLFIEVVVSATSEAELNK----LISTREIDVERAKKSGKDLKGTVEM-STLFSSCYNLLMVLFERNIRHPFTNDRFWLS-----------------SSH----------KPSQFMADL---------KKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPI--GAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSG-LYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            +W LI +      +GS+     +I + S   +     +  L ++F  +  +  I + D E F  E           FT+ ELV ++       + ++  A  E +       + + R + V+   +  + ++   +    LF    NL+ ++  R+IR PF  +  WLS                 + H           P Q   D+          +E+ +A  +L  +P ++  +ERV +F   I ADK  +          D P   G  +++RR  + ED YD+L   N  D KK+IRV  +N  G+DE GID  G+F+EFL E LK+  NP+   F TT++  LYP+P +  L  ++    + +LGR++ KA+YE +L+E PFA+FFL+++L    ++    I  L +LD ++Y++L ++K Y+ DV +L L F+   + LG+ +  +L+PGG+ I VT   +I+Y+H+VA +R+ + +R    AF+ G  +++  +W  MF   E+  LI G    I ++DLK    YSGG+ A H VI   W++++  F+E EK   L+FVTSCS+PPLLGF  L P+F   C+H+                         +D++RLP+A+TC NLLKLP +  + ++R KL Y I S AGFEL
Sbjct:  459 LWHLITSMTTKMITGSMVPLLQLISRGSPMSFEDSNRIIPLFYLFSSLFSHSLISVHDSEFFGHEMEGHVQSFMMPFTLSELVALSRCLRDACLGIIKLAYPETKTEHREEYMAAFRSVGVKTNNEVQQRIQAEQKRWVQLFKVITNLVKMVKARDIRRPFCPEGHWLSDEVNIRADKVTQLYVPSARHVWRTRRMGRIGPLQSTLDVGLEPPQLSVSEERNLA--ILTELPFVVPFEERVKIFQRLIFADKRDV--------QGDGPFSDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAEMLVGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLL---GTSADVDIHHLASLDPEMYRNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKHMRPHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAYVPISLEDLKNFTNYSGGYSANHPVIQIFWEVVEG-FTEEEKRKLLRFVTSCSRPPLLGFKELHPAF---CIHNGG-----------------------SDLERLPTASTCMNLLKLPEFCDQQSMRSKLLYAIESSAGFEL 1080
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Medaka
Match: huwe1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:101170019])

HSP 1 Score: 177.563 bits (449), Expect = 3.209e-44
Identity = 131/390 (33.59%), Postives = 188/390 (48.21%), Query Frame = 3 
Query: 2301 VISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRL-YPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGA-GFEL 3464
             + VRR  + ED Y +L + + +D K ++ + F  E G D       G+ +E+     + + NP   LF T+  +R+ Y    S     NHL  F+++GR++AKA+Y+  L+E  F   F   +L K  S  Y+   ++ + D   ++ L Y+   D      ELTFS +    G  E  DL+P G  I VT + K  YVH+V + +M   IR Q  AF  GFY II +    +F+  E+  LI G    ID+DDLK N  Y   + +    I W W  L++ F + +++ FL+FVT  SK PL GFA LE    I+                      F + +      RLPSA TCFN L LP YES   LR  L   I   + GF L
Sbjct: 3767 AVHVRRDHVFEDSYRELHRKSPEDMKNRLYIVFEGEEGQDA-----GGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRVVAKAVYDNRLLECYFTRSFYKHILGK--SVRYT---DMESEDYPFFQGLVYLLENDVSTLGYELTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMKMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISG-LPTIDIDDLKANTEYH-KYQSSSIQIQWFWRALRS-FDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQ---------------------KFQIHRDDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECSEGFGL 4122
[Close]
BLAST of HECT domain-containing protein vs. Ensembl Medaka
Match: hace1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [Source:NCBI gene;Acc:101171521])

HSP 1 Score: 169.088 bits (427), Expect = 2.522e-42
Identity = 130/474 (27.43%), Postives = 219/474 (46.20%), Query Frame = 3 
Query: 2037 LLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDL--ELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGA 3452
            +L     RN +  F +  F L      S+FM  +K + F               K+R   F+E + A +   G++ R  +  D     ++ + R  +     D + K   +  K+ I VRF  E GM +      GV +E+ +     ++NP   LF  ++D   +    +     +HL  FQ+ G+++  A+Y   L+     N + T+  +K    +     +++++D +  K+L ++   D D+SDL  ELTFS + D  G +E   L+ GG    VT + K  YV +V   RM + I+ Q  AF  GF++ I      +F   E L+L+      IDV+D  +N  Y+ G+     V+ W W+++K   ++ E+ L L+FVT  S+ P  GFA+L                      GS L+  FT++        LP+A+TC N+LKLP Y S   L+++L   ++ G+
Sbjct:  441 VLKCFVTRNPKIIFNHFHFLLECPELMSRFMHIIKAQPF---------------KDRAEWFYEHLLAGQPDSGMVHRPVSESD-----ILLIHRDSIFRSSCDSVSKSTNEKLKQGIAVRFHGEEGMGQ------GVVREWFDILSSEIINPDYALFTQSADGTTFQPNSNSSVNPDHLNYFQFAGQILGLALYHRQLV-----NIYFTRSFYKHILGIPVSYQDVSSIDPEYAKNLQWI--LDNDISDLGLELTFSVETDVFGAMEEVPLKAGGTTTLVTQENKAEYVQLVTELRMTRAIQPQINAFLRGFHTFIPPSLIQLFDEYE-LELLLSGMPEIDVEDWFRNTEYTSGYSDQEPVVQWFWEVVKG-LTQEERILLLQFVTGSSRVPHGGFAFL--------------------MGGSGLQK-FTIAAMPYTPNLLPTASTCINMLKLPEYPSLVVLQDRLLVALHCGS 858
[Close]
BLAST of HECT domain-containing protein vs. Planmine SMEST
Match: SMESG000048038.1 (SMESG000048038.1)

HSP 1 Score: 2130.14 bits (5518), Expect = 0.000e+0
Identity = 1103/1106 (99.73%), Postives = 1105/1106 (99.91%), Query Frame = 3 
Query:  147 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTXXXXXXXXXXXXXMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMXXXXXXXXXXXXXSRWKIVMAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCXXXXXXXXXXXXLIGPIFKLPRLPTSGSFWKKLHFSYKASTTNEXXXXXXXXXXXXXVCMLYFFTTSSLSQIRDDILAGVSLTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTSIDSSKSSHSYISMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMNVILTLIINILTVSRWKIV+AMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCKSSISSNKENKKLIGPIFKLPRLPTSGSFWKKLHFSYK STTNEQISISQIPLSIQSVCMLYFFTTSSLSQIRDDILAGVSLTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQR+VEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVFKEFLEETLKTLLNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL
Sbjct:    1 MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLVKKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYEHLCRQLLTSIDSSKSSHSYISMVLKKDSIVEWIRLSNWILYNACDSLGTIEPALQHDCRQMNVILTLIINILTVSRWKIVVAMNNSNLSQQLSKITDTLYSRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTETYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKNQMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLNQSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRSMFDELYDQPILDKNRCKSSISSNKENKKLIGPIFKLPRLPTSGSFWKKLHFSYKTSTTNEQISISQIPLSIQSVCMLYFFTTSSLSQIRDDILAGVSLTDLPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLFIILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLISTREIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFWLSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRIVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVFKEFLEETLKTLLNPSLNLFCTTSDNRLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 1106
[Close]
BLAST of HECT domain-containing protein vs. Planmine SMEST
Match: SMESG000055056.1 (SMESG000055056.1)

HSP 1 Score: 229.565 bits (584), Expect = 3.490e-61
Identity = 148/436 (33.94%), Postives = 231/436 (52.98%), Query Frame = 3 
Query: 2166 LLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDS-PIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNRLYPSP-LSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHA-GHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            +LK +P II    R+ LF E           L    N+  S  +   I +RR  + ED + Q+ +    + +  +++ FI+  GM+E G+D  G+ +EFL   +K   +P   LF +T +N +YP+P L  LY  N      + GRM+   I++ +L+EA FA FF+ ++ +   S     ID L  LD+DLY++L  +K  D  V ++ L F+      G  +T +L+P G +I+VTN  KI Y+++VA +++ +QI  QT     G   ++  + F +F + E+  +I G   LID+DDL++N  Y G        +I   W +L  E SE+EK  F++FVTS S+ P+LGF+ L P F+I+ V  +D                           RLP+A+TC NLLKLP Y++   +REKL Y I S +GF+L
Sbjct:  694 ILKEMPFIIPIGTRMKLFKE-----------LLGGMNYPTSFAMIPPIRIRRDYLYEDAFSQIKRKTFTNLRSYLKIEFIDRFGMNEPGVDGGGLLREFLRNIIKEACDPKRGLFVSTKNNLIYPNPELETLYPDNWQEHLDFFGRMLGLMIFKGLLVEASFAPFFIQKLFNNSSSREEIDIDNLQYLDEDLYRNLLSLKSMDR-VEEINLDFTVSRSCYGVSQTVELKPNGEHISVTNSNKIEYIYLVADYKLNRQISKQTSLIINGLNDVVPIECFQLFDLDEISFIITGGDSLIDLDDLQRNTIYHGVDDPDSSEIIQTFWRVLF-EMSEDEKRNFIQFVTSISRAPMLGFSELSPKFAIQIVPDTD---------------------------RLPTASTCINLLKLPAYQNLEEMREKLLYAIGSDSGFQL 1089
[Close]
BLAST of HECT domain-containing protein vs. Planmine SMEST
Match: SMESG000013095.1 (SMESG000013095.1)

HSP 1 Score: 158.688 bits (400), Expect = 2.918e-39
Identity = 128/437 (29.29%), Postives = 203/437 (46.45%), Query Frame = 3 
Query: 2160 KFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVN-TDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLF-CTTSDN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFE 3461
            KF    VP+   +K++   F  K++A +                    + + R+ + ED Y  +  V  T+  K K+ + FI E G+D       GV +E+     + + NP   LF  + +DN  L  +PLSG+  +NHL  F+++GR+   A+Y   L++  F       +L K+ S     + ++ ++D + Y+SL ++   + D + L+LTFS DE+  G+    DL P GR   VT + K  Y+  +  +R  +++  Q  AF  GF  ++  +   +F   E+  L+CG    I+V D K N  Y G ++  H VIV  W  +   F+   +S  L+FVT  S+ P+ GF  L                      GS     FT+ +K     +LP A TCFN L LP Y +   LR KL   I +  GFE
Sbjct:  472 KFSGPAVPYSRNYKQKYDYFRSKLRAPREPNAKFE-------------MRINRKNIFEDSYRLIYNVKKTEMLKYKLWIEFIGEKGLD-----YGGVQREWFFLLSREMFNPYYGLFEYSAADNYTLQINPLSGVANENHLRYFKFIGRVAGMAVYHGRLLDGFFIRPLYKMMLGKKIS-----LKDMESVDTEYYRSLKFI--LENDPAVLDLTFSVDEEHFGQKVEVDLIPDGRSKAVTQENKRQYIECIINWRFVKRVESQMTAFLEGFQDVVTLNTLQIFDANELELLLCGLQD-INVTDWKGNTNYKGEYNPNHPVIVNFWKTVYT-FNNELRSRLLQFVTGTSRVPMNGFVEL---------------------WGSTGPQKFTI-EKWGTPDQLPRAHTCFNRLDLPPYVTFEELRRKLLIAIENAEGFE 859
[Close]
BLAST of HECT domain-containing protein vs. Planmine SMEST
Match: SMESG000013095.1 (SMESG000013095.1)

HSP 1 Score: 158.688 bits (400), Expect = 4.209e-39
Identity = 128/437 (29.29%), Postives = 203/437 (46.45%), Query Frame = 3 
Query: 2160 KFLLKYVPHIIAHKERVVLFHEKIKADKASLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVN-TDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLF-CTTSDN-RLYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFE 3461
            KF    VP+   +K++   F  K++A +                    + + R+ + ED Y  +  V  T+  K K+ + FI E G+D       GV +E+     + + NP   LF  + +DN  L  +PLSG+  +NHL  F+++GR+   A+Y   L++  F       +L K+ S     + ++ ++D + Y+SL ++   + D + L+LTFS DE+  G+    DL P GR   VT + K  Y+  +  +R  +++  Q  AF  GF  ++  +   +F   E+  L+CG    I+V D K N  Y G ++  H VIV  W  +   F+   +S  L+FVT  S+ P+ GF  L                      GS     FT+ +K     +LP A TCFN L LP Y +   LR KL   I +  GFE
Sbjct:  512 KFSGPAVPYSRNYKQKYDYFRSKLRAPREPNAKFE-------------MRINRKNIFEDSYRLIYNVKKTEMLKYKLWIEFIGEKGLD-----YGGVQREWFFLLSREMFNPYYGLFEYSAADNYTLQINPLSGVANENHLRYFKFIGRVAGMAVYHGRLLDGFFIRPLYKMMLGKKIS-----LKDMESVDTEYYRSLKFI--LENDPAVLDLTFSVDEEHFGQKVEVDLIPDGRSKAVTQENKRQYIECIINWRFVKRVESQMTAFLEGFQDVVTLNTLQIFDANELELLLCGLQD-INVTDWKGNTNYKGEYNPNHPVIVNFWKTVYT-FNNELRSRLLQFVTGTSRVPMNGFVEL---------------------WGSTGPQKFTI-EKWGTPDQLPRAHTCFNRLDLPPYVTFEELRRKLLIAIENAEGFE 899
[Close]
BLAST of HECT domain-containing protein vs. Planmine SMEST
Match: SMESG000039114.1 (SMESG000039114.1)

HSP 1 Score: 155.221 bits (391), Expect = 2.032e-38
Identity = 118/389 (30.33%), Postives = 192/389 (49.36%), Query Frame = 3 
Query: 2304 ISVRRQRMVEDGYDQLMKVNTDDFKKKIRVRFINELGMDEVGIDLDGVXXXXXXXXXXXXXNPSLNLFCTTSDNR--LYPSPLSGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMYSFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLRPGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFDMFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNEFSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVGSLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINSGAGFEL 3464
            I+V R+ ++ D ++Q+M++     +K++ + F       E G+D  GV +E+     + LLNP + LF    DN   L  +P S      HL  F+++GR +A A++    I++ F   F  ++L+K+       ++++  +D   Y SL ++K  D +  DLEL FS D + LGK+ET +L+PGG  I VT D K  Y+ ++  +R  + I +Q  +F  GF  ++  +W   F   E+  L+CG    I+VDD +++  Y   +    + I+  W  ++N  +E    L L+FVT   + P+ GF  L                     +GS     F + K   +   LP + TCFN L LP Y+S   L EKL Y I    GF +
Sbjct:  385 INVSRKDLLTDSFNQIMQIQPTHLRKRLYITF-----KGEEGLDYGGVAREWFFRLSQELLNPMICLFEYACDNNYSLKINPAS-FVNPEHLQYFRFVGRFIAMALFHGKFIDSGFTLSFYKRMLNKK-----PILEDIEAVDYLYYNSLKFIKEMDLNECDLELYFSADFEILGKLETQELKPGGHSILVTEDNKEEYIDLMVNWRFNRGIENQAESFIKGFNEVLPLNWLYYFDEKEIELLLCGMQD-INVDDWEKHTVYRH-YTQNSKQIIHFWKYVRNLTNEMRVRL-LQFVTGTCRLPIGGFKNL---------------------MGSNGPQKFCIEKVGKET-WLPRSHTCFNRLDLPPYKSFQQLSEKLNYAIKETEGFSM 737
The following BLAST results are available for this feature:
BLAST of HECT domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
UBE3B0.000e+037.24ubiquitin protein ligase E3B [Source:HGNC Symbol;A... [more]
UBE3B0.000e+037.24ubiquitin protein ligase E3B [Source:HGNC Symbol;A... [more]
UBE3B1.645e-13732.61ubiquitin protein ligase E3B [Source:HGNC Symbol;A... [more]
UBE3C7.045e-8038.53ubiquitin protein ligase E3C [Source:HGNC Symbol;A... [more]
UBE3B4.712e-7227.02ubiquitin protein ligase E3B [Source:HGNC Symbol;A... [more]
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BLAST of HECT domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
oxi-16.260e-15933.36OXidative stress Induced [Source:UniProtKB/TrEMBL... [more]
etc-11.258e-4930.20E3 ubiquitin-protein ligase etc-1 [Source:UniProt... [more]
wwp-11.107e-4128.32E3 ubiquitin-protein ligase [Source:UniProtKB/TrE... [more]
wwp-11.107e-4128.32E3 ubiquitin-protein ligase [Source:UniProtKB/TrE... [more]
wwp-11.293e-4128.32E3 ubiquitin-protein ligase [Source:UniProtKB/TrE... [more]
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BLAST of HECT domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG50870.000e+035.73gene:FBgn0035953 transcript:FBtr0333908[more]
CG50870.000e+035.64gene:FBgn0035953 transcript:FBtr0076520[more]
CG33569.585e-8038.13gene:FBgn0034989 transcript:FBtr0072262[more]
Nedd44.168e-4332.99gene:FBgn0259174 transcript:FBtr0299642[more]
Nedd46.048e-4332.99gene:FBgn0259174 transcript:FBtr0300520[more]
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BLAST of HECT domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ube3b0.000e+037.63ubiquitin protein ligase E3B [Source:ZFIN;Acc:ZDB-... [more]
ube3c2.024e-8436.40ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-... [more]
ube3c2.024e-4934.05ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-... [more]
hace18.438e-4528.48HECT domain and ankyrin repeat containing E3 ubiqu... [more]
nedd4l8.007e-4229.86NEDD4 like E3 ubiquitin protein ligase [Source:ZFI... [more]
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BLAST of HECT domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ube3b0.000e+038.10ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
ube3b0.000e+037.68ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
ube3b0.000e+037.41ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
ube3b0.000e+036.57ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
ube3b6.892e-15333.94ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
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BLAST of HECT domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ube3b0.000e+037.11ubiquitin protein ligase E3B [Source:MGI Symbol;Ac... [more]
Ube3c1.988e-7938.07ubiquitin protein ligase E3C [Source:MGI Symbol;Ac... [more]
Nedd43.128e-4430.63neural precursor cell expressed, developmentally d... [more]
Huwe11.268e-4333.59HECT, UBA and WWE domain containing 1 [Source:MGI ... [more]
Huwe11.279e-4333.59HECT, UBA and WWE domain containing 1 [Source:MGI ... [more]
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BLAST of HECT domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q7Z3V4|UBE3B_HUMAN0.000e+037.24Ubiquitin-protein ligase E3B OS=Homo sapiens OX=96... [more]
sp|Q9ES34|UBE3B_MOUSE0.000e+037.11Ubiquitin-protein ligase E3B OS=Mus musculus OX=10... [more]
sp|Q08CZ0|UBE3B_XENTR0.000e+038.10Ubiquitin-protein ligase E3B OS=Xenopus tropicalis... [more]
sp|Q8RWB8|UPL6_ARATH1.258e-9633.39E3 ubiquitin-protein ligase UPL6 OS=Arabidopsis th... [more]
sp|Q9SCQ2|UPL7_ARATH3.336e-9636.56E3 ubiquitin-protein ligase UPL7 OS=Arabidopsis th... [more]
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BLAST of HECT domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0RH022.290e-5657.76Putative ubiquitin-protein ligase OS=Fasciola hepa... [more]
A0A0X3QG233.398e-5958.03HECT domain-containing protein OS=Schistocephalus ... [more]
G7YG621.949e-3158.65Ubiquitin-protein ligase E3 B OS=Clonorchis sinens... [more]
A0A075A6X41.480e-3958.65HECT domain-containing protein OS=Opisthorchis viv... [more]
A0A4S2MAH83.381e-5658.65HECT domain-containing protein OS=Opisthorchis fel... [more]
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BLAST of HECT domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ube3b0.000e+038.30ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
ube3b0.000e+038.30ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
ube3b0.000e+039.68ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
ube3c5.334e-8636.78ubiquitin protein ligase E3C [Source:NCBI gene;Acc... [more]
ube3c9.293e-8636.78ubiquitin protein ligase E3C [Source:NCBI gene;Acc... [more]
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BLAST of HECT domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ube3b0.000e+036.83ubiquitin protein ligase E3B [Source:ZFIN;Acc:ZDB-... [more]
ube3c9.665e-8235.31ubiquitin protein ligase E3C [Source:ZFIN;Acc:ZDB-... [more]
nedd4a2.755e-4530.18NEDD4 E3 ubiquitin protein ligase a [Source:ZFIN;A... [more]
ube3a5.776e-3429.23ubiquitin protein ligase E3A [Source:ZFIN;Acc:ZDB-... [more]
wwp27.125e-3431.10WW domain containing E3 ubiquitin protein ligase 2... [more]
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BLAST of HECT domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
HUL55.161e-5535.54Multiubiquitin chain assembly factor (E4); proteas... [more]
RSP52.075e-3928.83NEDD4 family E3 ubiquitin ligase; regulates proces... [more]
TOM14.427e-3829.45E3 ubiquitin ligase of the hect-domain class; has ... [more]
HUL41.821e-1825.85Protein with similarity to hect domain E3 ubiquiti... [more]
UFD49.801e-1826.15Ubiquitin-protein ligase (E3); interacts with Rpt4... [more]
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BLAST of HECT domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO473990.000e+037.49Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO460712.283e-4432.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO493271.728e-4329.77Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO493832.337e-3529.06Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO403021.973e-3327.04Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of HECT domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ube3b0.000e+038.27ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
ube3b0.000e+036.25ubiquitin protein ligase E3B [Source:NCBI gene;Acc... [more]
ube3c3.116e-8231.27ubiquitin protein ligase E3C [Source:NCBI gene;Acc... [more]
huwe13.209e-4433.59HECT, UBA and WWE domain containing E3 ubiquitin p... [more]
hace12.522e-4227.43HECT domain and ankyrin repeat containing E3 ubiqu... [more]
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BLAST of HECT domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000048038.10.000e+099.73SMESG000048038.1[more]
SMESG000055056.13.490e-6133.94SMESG000055056.1[more]
SMESG000013095.12.918e-3929.29SMESG000013095.1[more]
SMESG000013095.14.209e-3929.29SMESG000013095.1[more]
SMESG000039114.12.032e-3830.33SMESG000039114.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30008012 ID=SMED30008012|Name=HECT domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3801bp
ATATTATTTTATCCGTATTTTGTTTTAATATTAAGAGTAAACTGTCACTT
GGGTCTAAAGTAATAGCCAAATGATTTCTGTACTGCATTCAAAATTTTTT
TTCAAATAAATATTAGATTCTACAGAATTTGATTTTAGACTAAGTTATGT
ACACGCCACTAAAATCAGAAGTCCCTAGTTTTTTAGAAAAAACTAAAAAA
GAACGAGAAACTCGCAGATTGGAAGGAGTTAGACAGAAGTCTGCAATCAT
TATTCAAAGATATTATCGTGGATTTATAATTCGCAAAAATCTTGTTAAGA
AAATAAGGGATGAATTCAGACAATGTTTAGATATTAACAATGACGACAGT
TGTAAATATGAACCTATCGAAGTCAATAAGCTAGTGAGAGCGATCAAATG
TCTGCGGTATAATTTCAAAATAAATTCCGATAAAAAGAATTACGAGCACC
TCTGTCGCCAACTGCTTACGAGTATCGACTCATCTAAAAGCTCACATTCC
TATATCAGTATGGTCCTCAAGAAGGATTCAATTGTAGAATGGATTCGACT
CAGTAATTGGATACTATACAATGCCTGTGATTCCCTGGGTACTATCGAGC
CGGCATTGCAACATGATTGCCGACAGATGAATGTTATCCTCACTCTCATA
ATTAACATTTTGACGGTTTCCCGATGGAAAATTGTCATGGCAATGAACAA
TTCCAATCTTAGTCAGCAATTGAGCAAAATTACCGACACGCTTTATAGCA
GGATGCTCAAAGCGAATATGTTGAAGACCATGAAGGATTTGCTGTTGAAA
GGGGTCTGTAGGCAAACTATTCACTTAAGCCAGATTTCACTGAATGGAAT
TATGACTCTCATTTTGAGACTATTCCAGGATGTGAGACTTACAGAAACAT
ATCTTGAACCATTTATTATTAATATATTATCAGTCCCAGCCCTTGTGAAA
CATATGCACATTATGGTGAATGAAATATTCCAAATGATTCTCAGAGACCG
CTTGTGCACAAAAATAATTCTTCATCTACATTCAGATCCAAAAAACCAAA
TGAAAATATTTTCCCAGCTTCCACCTTCATACTCTCTTTGTATAATCGCG
AATATCATCGACCTTGGTCTGCTTGAAATGGATGTGCTAGCAAACCATGG
GTCCGAATTTTGTACAGTTCTATCTAGTCTTCTTGTTAAACTGAACCAAT
CTATCAATGAGACAATTTCTTCATCCTCTCACTACCATCATATTTTTGGT
TGGTCCGGAGTATCAATGGATGAAAATATCCAAAGCTCAATGGTGCATTT
ACGAAATCAGCTTAAACTCCTCTGGAGTAGTAAAATGATTAGATCTATGT
TTGATGAGTTGTATGATCAGCCAATTCTTGATAAAAATAGATGTAAATCC
TCTATCAGTAGTAATAAAGAAAACAAAAAATTAATTGGTCCTATTTTCAA
GTTGCCCCGATTACCAACAAGTGGTAGTTTTTGGAAAAAACTCCATTTTT
CCTATAAAGCATCTACCACAAATGAACAGATTTCCATATCTCAGATTCCG
TTATCTATTCAATCGGTTTGCATGCTTTATTTCTTTACTACTAGCTCATT
GTCTCAGATTCGCGACGATATCCTTGCGGGTGTCTCACTTACTGATTTGC
CAGCTCGAATGTGGCGACTTATCCAGAACAGTGGATCAGTTAAACAATGG
GCGAACATTATTAAGGATTCAGATTCCGGTTGGTATTCTCAGCCGCATGT
TAGCCACCTTCTTCACATTTTCGTCCTTATCGCTAGGAATCTATTCATAA
TTCTAGACGATCATGAAGTGTTTGAAAAAGAAAAAGTATTTACAGTAGGA
GAACTGGTAGAAATGGCCGATTTTTTCAACCATTTATTCATTGAAGTAGT
CGTCAGTGCAACCTCTGAAGCGGAACTTAATAAGTTAATTTCTACCAGAG
AAATTGATGTTGAACGAGCTAAGAAGTCCGGGAAAGATTTAAAAGGAACT
GTTGAAATGTCGACTTTGTTTAGTAGCTGTTACAATTTACTTATGGTGCT
TTTTGAACGCAATATTCGACATCCTTTCACCAATGATAGATTTTGGCTGT
CTAGCTCTCATAAACCATCGCAATTTATGGCTGATTTGAAGAAGGAGAAA
TTTGTGGCTAAATTCTTGTTGAAGTACGTTCCCCATATAATTGCACATAA
AGAGAGAGTAGTGTTATTTCATGAAAAAATCAAAGCAGATAAAGCATCAT
TAGGATTGTTATCGCGTAATTGGAATCATGATGACAGTCCTATTGGGGCA
GTTATATCAGTCCGGAGGCAAAGGATGGTTGAAGATGGCTACGATCAATT
AATGAAAGTCAATACTGATGATTTCAAGAAAAAAATTCGAGTTCGATTTA
TCAATGAATTGGGAATGGACGAGGTTGGAATTGATTTAGATGGAGTTTTC
AAGGAATTTTTAGAAGAGACCTTGAAAACCTTACTTAATCCCAGCCTCAA
TCTGTTTTGCACGACATCCGATAATCGGCTTTATCCGTCACCTTTATCCG
GACTGTACGAACAAAACCATTTACTTCTCTTTCAATATCTCGGTCGAATG
ATGGCCAAAGCAATTTATGAGGAAATACTTATTGAAGCTCCATTTGCCAA
TTTCTTCCTTACTCAGGTTCTGCATAAAGAGCAGTCCAATATGTACAGTT
TTATTGACGAGCTGAATACTCTCGATAAAGATTTGTATAAAAGTTTAACT
TATGTTAAACATTATGATGGTGACGTGAGTGACTTGGAATTGACGTTCTC
TTACGACGAAGATCGATTGGGTAAAATTGAAACTCATGACCTCCGACCCG
GTGGGAGATATATAACTGTAACGAATGATACGAAAATCAGTTACGTCCAT
ATTGTTGCGAGGTTTCGTATGTTTCAACAAATTCGTGATCAAACTAGAGC
ATTTAAAATGGGGTTCTATTCAATAATACAGAGAGATTGGTTTGATATGT
TTTCAGTGCCGGAAATGTTAAAATTAATTTGTGGAGATACTGGGTTAATC
GATGTCGATGACTTGAAGCAAAATGTTCGATATTCGGGAGGATTTCACGC
AGGACATCGCGTTATAGTTTGGCTGTGGGATATATTGAAAAACGAATTTT
CCGAAAATGAGAAAAGTCTATTTTTAAAATTCGTCACAAGTTGTTCAAAA
CCTCCTCTATTGGGATTTGCTTATCTGGAGCCTTCATTCTCAATTCGTTG
CGTGCACTCATCCGATGAAGATCAGGAGGCCGAGGATACGGTTGGATCGC
TGCTGAAGAATATTTTCACAATGTCGAAAAAGAAAAACGACATCAAAAGG
CTGCCTTCAGCGGCAACTTGTTTCAATTTGCTGAAACTTCCCAATTACGA
ATCGAAATCCACTCTCAGAGAGAAATTGCGTTATGTCATTAACTCGGGCG
CAGGATTCGAACTATCTTAATCTTAACGTTACTATTCCAGTATTCGCATA
GACTTCTGTACTTTTCATTCACAATTGCTCCAATTCACTATTGGTCACCA
CAATTTCCACTGGGGATATTCTGGAGTTTTTTTATTTCATTGATTACTGT
TTTGATCTTACACATCCTTTCTGATTGATCATTTTGTTTCCTGATCTTAC
ATTGAATACAATTGATGCAGTTGAATGCTCTTGTTTGTCTCATAGCTGCT
GACAAAATGAAATATAAATATTATTTATTTACTTTTATTGTTTAATTAGG
TAAATGTTTGTATTGAATTATCTTGAAATTTTACAATAACATTTAATTTT
A
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protein sequence of SMED30008012-orf-1

>SMED30008012-orf-1 ID=SMED30008012-orf-1|Name=SMED30008012-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1108bp
MYTPLKSEVPSFLEKTKKERETRRLEGVRQKSAIIIQRYYRGFIIRKNLV
KKIRDEFRQCLDINNDDSCKYEPIEVNKLVRAIKCLRYNFKINSDKKNYE
HLCRQLLTSIDSSKSSHSYISMVLKKDSIVEWIRLSNWILYNACDSLGTI
EPALQHDCRQMNVILTLIINILTVSRWKIVMAMNNSNLSQQLSKITDTLY
SRMLKANMLKTMKDLLLKGVCRQTIHLSQISLNGIMTLILRLFQDVRLTE
TYLEPFIINILSVPALVKHMHIMVNEIFQMILRDRLCTKIILHLHSDPKN
QMKIFSQLPPSYSLCIIANIIDLGLLEMDVLANHGSEFCTVLSSLLVKLN
QSINETISSSSHYHHIFGWSGVSMDENIQSSMVHLRNQLKLLWSSKMIRS
MFDELYDQPILDKNRCKSSISSNKENKKLIGPIFKLPRLPTSGSFWKKLH
FSYKASTTNEQISISQIPLSIQSVCMLYFFTTSSLSQIRDDILAGVSLTD
LPARMWRLIQNSGSVKQWANIIKDSDSGWYSQPHVSHLLHIFVLIARNLF
IILDDHEVFEKEKVFTVGELVEMADFFNHLFIEVVVSATSEAELNKLIST
REIDVERAKKSGKDLKGTVEMSTLFSSCYNLLMVLFERNIRHPFTNDRFW
LSSSHKPSQFMADLKKEKFVAKFLLKYVPHIIAHKERVVLFHEKIKADKA
SLGLLSRNWNHDDSPIGAVISVRRQRMVEDGYDQLMKVNTDDFKKKIRVR
FINELGMDEVGIDLDGVFKEFLEETLKTLLNPSLNLFCTTSDNRLYPSPL
SGLYEQNHLLLFQYLGRMMAKAIYEEILIEAPFANFFLTQVLHKEQSNMY
SFIDELNTLDKDLYKSLTYVKHYDGDVSDLELTFSYDEDRLGKIETHDLR
PGGRYITVTNDTKISYVHIVARFRMFQQIRDQTRAFKMGFYSIIQRDWFD
MFSVPEMLKLICGDTGLIDVDDLKQNVRYSGGFHAGHRVIVWLWDILKNE
FSENEKSLFLKFVTSCSKPPLLGFAYLEPSFSIRCVHSSDEDQEAEDTVG
SLLKNIFTMSKKKNDIKRLPSAATCFNLLKLPNYESKSTLREKLRYVINS
GAGFELS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR000048IQ_motif_EF-hand-BS
IPR000569HECT_dom
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0004842ubiquitin-protein transferase activity
GO:0016740transferase activity
Vocabulary: biological process
TermDefinition
GO:0016567protein ubiquitination