Deoxyribonuclease II family protein

Overview
NameDeoxyribonuclease II family protein
Smed IDSMED30007970
Length (bp)1163
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Deoxyribonuclease II family protein (SMED30007970) t-SNE clustered cells

Violin plots show distribution of expression levels for Deoxyribonuclease II family protein (SMED30007970) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Deoxyribonuclease II family protein (SMED30007970) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Deoxyribonuclease II family protein (SMED30007970) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30007970

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30007970SMESG000060779.1 Contig4893GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30007970SMESG000062993.1 Contig4893GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30007970SMESG000062993.1 dd_Smed_v4_1643_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30007970SMESG000062993.1 dd_Smed_v4_1643_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30007970SMESG000062993.1 dd_Smed_v4_1643_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Human
Match: DNASE2 (deoxyribonuclease 2, lysosomal [Source:HGNC Symbol;Acc:HGNC:2960])

HSP 1 Score: 184.882 bits (468), Expect = 2.043e-54
Identity = 108/355 (30.42%), Postives = 172/355 (48.45%), Query Frame = 2 
Query:   44 VALIFNILHQLAICELSCKNDNNQDIEWFIGLKFP----------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFT----YSSRGHLKGVISFDINNGFWLIHSVPLFP---TFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNL----PENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPGAK---FRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            + L+   L  +    L+C  D+ Q ++WF+  K P          +  ++ Y+   S  W   +  ++S    +G +++  Y S+ SQ  +  YND+ P+ +     S RGH KGV+  D + GFWL+HSVP FP   +   Y++  +   YGQ+ +CVS        +  QL      VY+Y L     + FP        L N +   ++  +  N +I + +        F K   FG DLYSG +A  L  ++ V+ W +   +  S C   + V NV ++  PG     F  + DHSKW VS     P+ C+GD+NR   + +RGGGTLC +   +WK FQP+V +++ C
Sbjct:    2 IPLLLAALLCVPAGALTCYGDSGQPVDWFVVYKLPALRGSGEAAQRGLQYKYLDESSGGWRDGRALINSPEGAVGRSLQPLYRSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGVLLLDHDGGFWLVHSVPNFPPPASSAAYSWPHSACTYGQTLLCVSFPFAQFSKMGKQLTYTYPWVYNYQLEGIFAQEFPD-------LENVVKGHHVSQEPWNSSITLTSQAGAVFQSFAKFSKFGDDLYSGWLAAALGTNLQVQFWHKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCVSPK--GPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPC 347
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Human
Match: DNASE2B (deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:HGNC:28875])

HSP 1 Score: 169.859 bits (429), Expect = 1.432e-48
Identity = 103/334 (30.84%), Postives = 176/334 (52.69%), Query Frame = 2 
Query:   89 LSCKNDNNQDIEWFIGLKFPK---------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQS---FYAYYNDETPKFTYSSR--GHLKGVISFDINNGFWLIHSVPLFPTFGN--YTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRG-EKVDSTCGTNYHVYNVEKVNLPGAKFRESH-DHSKWAVSNN-QDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            +SC+N+  + ++WF   K PK           +++Y+ S + +W  S+  ++   +++G T++Q Y ++ S+S    Y  YND  PK    SR  GH KG++ ++   GFWLIHS+P FP      Y Y       GQS IC++ +    + I  QLL+    VYS ++P  F  + +L  +        + +I    +T  +++ +    +HF KS SF  D+++  +A  L+  ++ E+W R  +++ S C   YHVYN++ + L    +  S+ DH+KW +S     + + CIGD+NR   Q  R GG +C +N  I++ FQ +V  +E C
Sbjct:   30 ISCRNEEGKAVDWFTFYKLPKRQNKESGETGLEYLYLDSTTRSWRKSEQLMNDTKSVLGRTLQQLYEAYASKSNNTAYLIYNDGVPKPVNYSRKYGHTKGLLLWNRVQGFWLIHSIPQFPPIPEEGYDYPPTGRRNGQSGICITFKYNQYEAIDSQLLVCNPNVYSCSIPATF--HQELIHMPQLCTRASSSEIPGRLLTT-LQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESC 360
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Human
Match: DNASE2B (deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:HGNC:28875])

HSP 1 Score: 90.1225 bits (222), Expect = 5.188e-21
Identity = 44/137 (32.12%), Postives = 77/137 (56.20%), Query Frame = 2 
Query:  632 NMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRG-EKVDSTCGTNYHVYNVEKVNLPGAKFRESH-DHSKWAVSNN-QDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
             +   +++ +    +HF KS SF  D+++  +A  L+  ++ E+W R  +++ S C   YHVYN++ + L    +  S+ DH+KW +S     + + CIGD+NR   Q  R GG +C +N  I++ FQ +V  +E C
Sbjct:   16 RLLTTLQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESC 152
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Human
Match: DNASE2 (deoxyribonuclease 2, lysosomal [Source:HGNC Symbol;Acc:HGNC:2960])

HSP 1 Score: 56.6102 bits (135), Expect = 1.263e-8
Identity = 55/255 (21.57%), Postives = 95/255 (37.25%), Query Frame = 2 
Query:   44 VALIFNILHQLAICELSCKNDNNQDIEWFIGLKFP----------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTY----SSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESW 766
            + L+   L  +    L+C  D+ Q ++WF+  K P          +  ++ Y+   S  W   +  ++S    +G +++  Y S+ SQ  +  YND+ P+ +     S RGH KG           L ++ P       Y Y + E I+ Q F                             P+           L N +   ++  +  N +I + +        F K   FG DLYSG +A  L  ++ V+ W
Sbjct:    2 IPLLLAALLCVPAGALTCYGDSGQPVDWFVVYKLPALRGSGEAAQRGLQYKYLDESSGGWRDGRALINSPEGAVGRSLQPLYRSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGKQ---------LTYTYPWV-----YNY-QLEGIFAQEF-----------------------------PD-----------LENVVKGHHVSQEPWNSSITLTSQAGAVFQSFAKFSKFGDDLYSGWLAAALGTNLQVQFW 201
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Celegans
Match: crn-7 (Cell-death-related nuclease 7 [Source:UniProtKB/Swiss-Prot;Acc:P34387])

HSP 1 Score: 233.417 bits (594), Expect = 2.142e-73
Identity = 122/346 (35.26%), Postives = 195/346 (56.36%), Query Frame = 2 
Query:   50 LIFNILHQLAICELSCKNDNNQDIEWFIGLKFPK-------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETP-KFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTN--------MTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWI--RGEKVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            LIF+++      ++ CKN   + ++WF+  K PK         +FVY  ++S  WT    D++  N  +G T+ Q YS+ +S +F+  Y+D+ P K   S RGH KGV  FD   GFWLIHSVP FP   +++Y    E YGQSF C S+E ++L  +      +Q+T Y  N+PE +          T F   KN++ +Q+         ++  +KT++ + L+ + K   F  D+++ L++   + ++ VESW+   G+ + +TC +    ++V ++ + G  F  S DHSKWAVSN+Q +P VC GD+NR  SQ KRGGG LC++N+N+W+++   V   E C
Sbjct:    7 LIFSVIFTTGNGKIQCKNMRGKSVDWFVVYKLPKLSGAGTSGKEFVYFDAESSDWTRGN-DINDPNVAVGATVSQVYSADKSNNFWFMYSDDDPIKSADSYRGHAKGVSLFDSTTGFWLIHSVPNFPPIKSFSYPNTAEKYGQSFFCASMEVQHLTELAEHWKYIQATPYIINIPEKYA---------TRFPTLKNVEAKQSLPRSATQFWISKPIKTVQGVTLMAYAKHKKFDGDIWNDLISRQNKVTLAVESWLNGSGDDIHTTCTSTSQTHDVTEMRVTGLNFASSKDHSKWAVSNSQTNPIVCFGDMNRQKSQLKRGGGALCIQNRNLWQLYHSFVIQVEPC 342
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508])

HSP 1 Score: 186.037 bits (471), Expect = 4.205e-55
Identity = 115/360 (31.94%), Postives = 189/360 (52.50%), Query Frame = 2 
Query:   35 IIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPKSYK------------FVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTY--SSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIR--GEK--VDSTCGTNY--HVYNVEKVNLPGA-KFRESHDHSKWAVSNNQDS-----PYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCA 1036
            I Q+ LI +++  ++     CK++N  +++WF+  K P  +             F+Y    ++ W +    +  +NN + +T++Q Y+S+ + +F   YNDE P  T   +S GH KGV  FD   GFW+IHS+P FP+   + +      YGQ  IC+S  + +L  I  QL    +  Y +NLP++F     + + L N   NK+  +  T    ++K+L      HF K+  +G+DLYS  V P L++SI VE+W    G++  + S C  N+     + + + LP A  +    DHSK+ V+ ++ S     PYVCIGDINR + Q  RGGGT+C+ ++  +  F  I+++   C 
Sbjct:    2 IRQIILIVSLI-GISNAAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYFDVNNKNWKLMPQGMDVENNAVYYTLQQYYNSNMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTK---VLKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCT 357
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508])

HSP 1 Score: 186.037 bits (471), Expect = 4.205e-55
Identity = 115/360 (31.94%), Postives = 189/360 (52.50%), Query Frame = 2 
Query:   35 IIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPKSYK------------FVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTY--SSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIR--GEK--VDSTCGTNY--HVYNVEKVNLPGA-KFRESHDHSKWAVSNNQDS-----PYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCA 1036
            I Q+ LI +++  ++     CK++N  +++WF+  K P  +             F+Y    ++ W +    +  +NN + +T++Q Y+S+ + +F   YNDE P  T   +S GH KGV  FD   GFW+IHS+P FP+   + +      YGQ  IC+S  + +L  I  QL    +  Y +NLP++F     + + L N   NK+  +  T    ++K+L      HF K+  +G+DLYS  V P L++SI VE+W    G++  + S C  N+     + + + LP A  +    DHSK+ V+ ++ S     PYVCIGDINR + Q  RGGGT+C+ ++  +  F  I+++   C 
Sbjct:    2 IRQIILIVSLI-GISNAAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYFDVNNKNWKLMPQGMDVENNAVYYTLQQYYNSNMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTK---VLKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCT 357
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508])

HSP 1 Score: 186.037 bits (471), Expect = 4.587e-55
Identity = 115/360 (31.94%), Postives = 189/360 (52.50%), Query Frame = 2 
Query:   35 IIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPKSYK------------FVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTY--SSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIR--GEK--VDSTCGTNY--HVYNVEKVNLPGA-KFRESHDHSKWAVSNNQDS-----PYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCA 1036
            I Q+ LI +++  ++     CK++N  +++WF+  K P  +             F+Y    ++ W +    +  +NN + +T++Q Y+S+ + +F   YNDE P  T   +S GH KGV  FD   GFW+IHS+P FP+   + +      YGQ  IC+S  + +L  I  QL    +  Y +NLP++F     + + L N   NK+  +  T    ++K+L      HF K+  +G+DLYS  V P L++SI VE+W    G++  + S C  N+     + + + LP A  +    DHSK+ V+ ++ S     PYVCIGDINR + Q  RGGGT+C+ ++  +  F  I+++   C 
Sbjct:    2 IRQIILIVSLI-GISNAAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYFDVNNKNWKLMPQGMDVENNAVYYTLQQYYNSNMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTK---VLKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCT 357
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508])

HSP 1 Score: 186.037 bits (471), Expect = 4.587e-55
Identity = 115/360 (31.94%), Postives = 189/360 (52.50%), Query Frame = 2 
Query:   35 IIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPKSYK------------FVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTY--SSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIR--GEK--VDSTCGTNY--HVYNVEKVNLPGA-KFRESHDHSKWAVSNNQDS-----PYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCA 1036
            I Q+ LI +++  ++     CK++N  +++WF+  K P  +             F+Y    ++ W +    +  +NN + +T++Q Y+S+ + +F   YNDE P  T   +S GH KGV  FD   GFW+IHS+P FP+   + +      YGQ  IC+S  + +L  I  QL    +  Y +NLP++F     + + L N   NK+  +  T    ++K+L      HF K+  +G+DLYS  V P L++SI VE+W    G++  + S C  N+     + + + LP A  +    DHSK+ V+ ++ S     PYVCIGDINR + Q  RGGGT+C+ ++  +  F  I+++   C 
Sbjct:    2 IRQIILIVSLI-GISNAAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYFDVNNKNWKLMPQGMDVENNAVYYTLQQYYNSNMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTK---VLKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCT 357
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Fly
Match: DNaseII (gene:FBgn0000477 transcript:FBtr0083538)

HSP 1 Score: 179.104 bits (453), Expect = 2.292e-52
Identity = 110/347 (31.70%), Postives = 181/347 (52.16%), Query Frame = 2 
Query:   77 AICELSCKNDNNQDIEWFIGLKFPKSY------------KFVYISSQS-ETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFT-YSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGE-KVDSTCGTNYHVYNVEKVNLP--GAKFRESHDHSKWAVSNNQ----------DSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCA 1036
            A  ++SCK++   D++W+   K PK Y            K++Y++SQ+ +TW MS   +S   ++   T+    +   S +  A YND+ P  T +SS GH KGV++ D     W++HSVP FPT  +Y+Y  + E Y QS +CV+L+ E+L+  V Q+L+     + Y        +D+L   L   ++ +          + +++L       FGKS     +LY+ +VAP L  S+ VE+W  G   + ++C  +  V NVE ++ P     F+ + DHSKWAVS                ++C+GDINR   Q  RGGGT+C K+  +  +++ +V +++KCA
Sbjct:   19 AKSKVSCKDEAGNDVDWWHLYKLPKHYQHNDLGKDTSGLKYLYVTSQNYDTWQMSGKFISDPLSLPAQTL-NPLNDDPSHTLLAAYNDQQPNGTVFSSGGHAKGVVASDGETAIWIVHSVPKFPTIPDYSYPTSGEQYAQSMLCVTLKGEDLEK-VGQILVYNEPHFYYQRNPLATRSDELFPSLERALHGQWRTESPFQKDLEVRSLDGKKFRLFGKSGRANVELYADVVAPTLDVSLFVEAWRDGAGNLPNSCDKSDKVLNVESISNPELSVDFKTTQDHSKWAVSRPTGILIYHWRVGGGDWICVGDINRQEGQLHRGGGTVCHKSARVSNLYRQLVTNYDKCA 363
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Zebrafish
Match: dnase2b (deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GENE-090824-2])

HSP 1 Score: 189.119 bits (479), Expect = 1.901e-56
Identity = 113/338 (33.43%), Postives = 176/338 (52.07%), Query Frame = 2 
Query:   62 ILHQLAICELSCKNDNNQDIEWFIGLKFP--------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQS-QSFYAYYNDETPKFTYSSR-GHLKGVISFDINNGFWLIHSVPLFPTFG--NYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWI-RGEKVDSTCGTNYHVYNVEKVNLPGAK-FRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            +L QL+ C +SC N++ Q ++WFI  K P            ++Y+      + +SK+ ++S    +G T+ Q YS + S  S Y  YND  P+  Y S+ GH KGV+ FD + GFWL HSVP FP F   NY+Y    + YGQ+ +C++        I  QL  +   VY+ ++P  F  +      +    + K   I+       +++++      F KS ++  D+Y+G VA  L   ++VESW+ +  ++ S C   +HV N+  V LPG + FR   DHSKW VS      + C+GD+NR   Q  RGGG  C +N  I+K F+  +A ++ C
Sbjct:    3 VLFQLSACLISCLNEDGQPVDWFIMYKLPIYKMEVKGSGVDYMYLDPSIMDFQISKYTVNSSTGALGRTLTQLYSGYTSNSSVYMLYNDAPPELKYPSKYGHTKGVLMFDQDQGFWLTHSVPHFPPFPERNYSYPLTGKYYGQTLLCITFNYTQFPRISWQLAYLNPRVYNCSVPVAFRPD---IGEMAQICDGKTPAIKNRRSLQKLQSVQGQTFFSFAKSQNYVDDIYTGWVAQALGTDLLVESWLHQAHQLPSNCSLPWHVMNINAVCLPGPQMFRSYEDHSKWCVSYTFKDQWTCLGDLNRDGGQAGRGGGLTCCQNSVIYKAFRKAMARYKHC 337
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Zebrafish
Match: dnase2b (deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GENE-090824-2])

HSP 1 Score: 181.415 bits (459), Expect = 2.303e-53
Identity = 114/349 (32.66%), Postives = 176/349 (50.43%), Query Frame = 2 
Query:   62 ILHQLAICEL-----------SCKNDNNQDIEWFIGLKFP--------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQS-QSFYAYYNDETPKFTYSSR-GHLKGVISFDINNGFWLIHSVPLFPTFG--NYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWI-RGEKVDSTCGTNYHVYNVEKVNLPGAK-FRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            +L QL+ C L           SC N++ Q ++WFI  K P            ++Y+      + +SK+ ++S    +G T+ Q YS + S  S Y  YND  P+  Y S+ GH KGV+ FD + GFWL HSVP FP F   NY+Y    + YGQ+ +C++        I  QL  +   VY+ ++P  F  +      +    + K   I+       +++++      F KS ++  D+Y+G VA  L   ++VESW+ +  ++ S C   +HV N+  V LPG + FR   DHSKW VS      + C+GD+NR   Q  RGGG  C +N  I+K F+  +A ++ C
Sbjct:    3 VLFQLSACCLLFLMGFSEAVISCLNEDGQPVDWFIMYKLPIYKMEVKGSGVDYMYLDPSIMDFQISKYTVNSSTGALGRTLTQLYSGYTSNSSVYMLYNDAPPELKYPSKYGHTKGVLMFDQDQGFWLTHSVPHFPPFPERNYSYPLTGKYYGQTLLCITFNYTQFPRISWQLAYLNPRVYNCSVPVAFRPD---IGEMAQICDGKTPAIKNRRSLQKLQSVQGQTFFSFAKSQNYVDDIYTGWVAQALGTDLLVESWLHQAHQLPSNCSLPWHVMNINAVCLPGPQMFRSYEDHSKWCVSYTFKDQWTCLGDLNRDGGQAGRGGGLTCCQNSVIYKAFRKAMARYKHC 348
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Zebrafish
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:ZDB-GENE-010724-16])

HSP 1 Score: 175.252 bits (443), Expect = 9.163e-51
Identity = 112/354 (31.64%), Postives = 181/354 (51.13%), Query Frame = 2 
Query:   53 IFNILH--QLAICELSCKNDNNQDIEWFIGLKFPKSY--------KFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPK---FTYSSR--GHLKGVISFDINNGFWLIHSVPLFP---TFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNK--NMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPGAK--FRESHDHSKWAVSNNQDSP--YVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCAN 1039
            +  +LH  + A   +SC ND  + ++W+   K P  +        K++++  +SE WT     ++   + +G T+   Y        Y  YND+ PK      +SR  GH KGV+ FD   GFWL+HS P FP   + G ++Y  +    GQ+FICV+   E  Q I  QL + Q  ++  ++P +          L     ++  N     +N +I + +L     + F K  SF  DLY   VAP LQ++++V+ W R   +  S C  N+ V N++ ++ PG K  F+ + DHSKWAVS++  +   +VC+GDINR  ++ KRGGGT+C ++  +WK ++      E C+ 
Sbjct:    5 VLLLLHASRGAFSSISCYNDQGKPVDWYYLYKLPHEHHTPLEEGLKYLFMDVESEGWTDGTTLVNDTQSAVGRTVGPLYEG--GDVGYILYNDQPPKQKQVEGASRSCGHTKGVVVFDKEQGFWLVHSTPHFPPPKSEGQFSYPTSGISNGQNFICVTYPFERFQTIGEQLKINQPHIFDCSIPGSLATAVPAMAQLCKHTLDRWDNTSSSPSNRSISLLSLAKTEFISFAKGASFANDLYHSWVAPTLQSNLLVQFWRRSTGILPSDCSPNWEVLNIDLIS-PGQKVTFKATEDHSKWAVSSSSGTSGGWVCVGDINRDEAEEKRGGGTVCRRDAVVWKAYRSAALQCESCSG 355
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Zebrafish
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:ZDB-GENE-010724-16])

HSP 1 Score: 175.252 bits (443), Expect = 9.163e-51
Identity = 112/354 (31.64%), Postives = 181/354 (51.13%), Query Frame = 2 
Query:   53 IFNILH--QLAICELSCKNDNNQDIEWFIGLKFPKSY--------KFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPK---FTYSSR--GHLKGVISFDINNGFWLIHSVPLFP---TFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNK--NMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPGAK--FRESHDHSKWAVSNNQDSP--YVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCAN 1039
            +  +LH  + A   +SC ND  + ++W+   K P  +        K++++  +SE WT     ++   + +G T+   Y        Y  YND+ PK      +SR  GH KGV+ FD   GFWL+HS P FP   + G ++Y  +    GQ+FICV+   E  Q I  QL + Q  ++  ++P +          L     ++  N     +N +I + +L     + F K  SF  DLY   VAP LQ++++V+ W R   +  S C  N+ V N++ ++ PG K  F+ + DHSKWAVS++  +   +VC+GDINR  ++ KRGGGT+C ++  +WK ++      E C+ 
Sbjct:    5 VLLLLHASRGAFSSISCYNDQGKPVDWYYLYKLPHEHHTPLEEGLKYLFMDVESEGWTDGTTLVNDTQSAVGRTVGPLYEG--GDVGYILYNDQPPKQKQVEGASRSCGHTKGVVVFDKEQGFWLVHSTPHFPPPKSEGQFSYPTSGISNGQNFICVTYPFERFQTIGEQLKINQPHIFDCSIPGSLATAVPAMAQLCKHTLDRWDNTSSSPSNRSISLLSLAKTEFISFAKGASFANDLYHSWVAPTLQSNLLVQFWRRSTGILPSDCSPNWEVLNIDLIS-PGQKVTFKATEDHSKWAVSSSSGTSGGWVCVGDINRDEAEEKRGGGTVCRRDAVVWKAYRSAALQCESCSG 355
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Xenopus
Match: dnase2b (deoxyribonuclease II beta [Source:NCBI gene;Acc:496759])

HSP 1 Score: 199.519 bits (506), Expect = 2.750e-60
Identity = 104/336 (30.95%), Postives = 183/336 (54.46%), Query Frame = 2 
Query:   74 LAICELSCKNDNNQDIEWFIGLKFP---------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSH-QSQSFYAYYNDETPKFTYSSR-GHLKGVISFDINNGFWLIHSVPLFPTF--GNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKVDSTCGTNYHVYNVEKVNLPG-AKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCAN 1039
            +   E+SC+N+    I+WF+  K P             ++Y+ S ++ W +SKF +++  + +G  ++Q Y  + ++ + Y  YND  P  T S+R GH KG++ FD + GFWLIHSVP FP +    Y Y    + +GQ+ ICV+ +    + I  QLL     VY+ ++P+   +  K   +L       +     +     + + +    ++F KS  F  D+++  +A  L+ +++VESW   +++ S C   YHVYN+ ++ LP  + F+  +DHSKW VS + +  + CIGD+NR  +Q +R GG +C +NK+I+  F+ +V  ++ C +
Sbjct:    3 MVAAEISCRNEAGDPIDWFVVYKLPMLKMNGSTGSGLDYLYMDSTNQEWQISKFQINTTKSAVGQVLQQLYQDYDKNNTVYMIYNDAPPNVTNSTRKGHTKGILFFDNSQGFWLIHSVPHFPPYPEDGYGYPSTGKRFGQTAICVTYQYNEFKEIATQLLYYNPNVYNCSVPD---IYQKEMWMLHKICLGGHFPWIDSTRLTQLNSARGEVFLNFAKSKYFIDDIFAAWIAQKLRTNMLVESWQSRQQLSSNCSLQYHVYNINRIGLPTQSTFQTFYDHSKWCVSQSNEDLWTCIGDLNRHPAQTRRSGGFICTQNKHIYTAFRNMVLYYKNCTD 335
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Xenopus
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:NCBI gene;Acc:733868])

HSP 1 Score: 172.17 bits (435), Expect = 1.176e-49
Identity = 105/336 (31.25%), Postives = 168/336 (50.00%), Query Frame = 2 
Query:   77 AICELSCKNDNNQDIEWFIGLKFPK--------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSF-YAYYNDETPKFTYSS--RGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIY--GQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVN-DKLKTLLTNFINNKNMKIQQT-NMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPGA-KFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            +    SC  D+ + ++WFI  K P+           +VY  S S  W      ++S ++ +G T+ Q Y +   +   Y  YNDE    + S   RGH KG++  D   GFWL+HS P FP   + +Y      +  GQSF+CV+   +   +I  QLL      Y  ++PE+F V+  +LKT        K    Q   N  +++ ++       F K   F  DLYSG V+  L++ + V+ W     V  S C   +H YN+ ++++  A  F   +DHSKW V++   + + C+GD+NR   + +RGGGT+CV + N+WK F+ +V+ +  C
Sbjct:   15 SFAATSCYGDHGKQVDWFIVYKLPQLRNKGEEAGMTYVYQDSSSGGWVPGATLMNSTDSAVGQTVSQLYKAFGMKDVAYILYNDEPANISSSGSDRGHTKGMLLLDKKQGFWLVHSTPRFPPPADQSYDWPLSAHRNGQSFLCVTYPYKQFGDIGQQLLYNTILPYDSSIPEDFSVDFPELKTAA-----EKGAVTQPPWNRQVVLTSVGGKQFTSFSKHAHFSDDLYSGWVSQVLKSHLFVQFWQNSRGVLPSNCSLPFHTYNIMEIDISCAYSFSTHNDHSKWCVTDG--AGWACVGDMNRDVKEERRGGGTVCVNDPNVWKSFRSLVSSYNNC 343
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Mouse
Match: Dnase2b (deoxyribonuclease II beta [Source:MGI Symbol;Acc:MGI:1913283])

HSP 1 Score: 192.586 bits (488), Expect = 1.503e-57
Identity = 111/351 (31.62%), Postives = 184/351 (52.42%), Query Frame = 2 
Query:   29 MKIIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPK---------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAY--YNDETPKFTYSSR--GHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESW-IRGEKVDSTCGTNYHVYNVEKVNLPG-AKFRESHDHSKWAVS-NNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            ++ +   L F +   L   E+SC+N+  + ++WFI  K PK           +++Y+ S  +TW  S + ++S  + +G T++  Y +H S +  AY  YND  P     SR  GH KG++ ++   GFWLIHSVP FP    Y Y  +   YGQ+ IC++      + I  QLL++Q  +YS  +P  F  + KL  +     N+ ++KI    +   + + + L  VHF KS  +  D+++G +A  L+  ++ ++W  + +++ S C   YHVYN++ + +   + F    DHSKW VS     + + CIGD+NR   Q  RGGG +C KN  I++ F  +   +  C
Sbjct:    6 LRTVLSLLFFALSGVLGTPEISCRNEYGEAVDWFIFYKLPKRTSKASEEAGLQYLYLDSTRQTWNKSLYLINSTRSALGRTLQHLYDTHNSTNDTAYLIYNDGVPGSVNYSRQYGHAKGLLVWNRTQGFWLIHSVPKFPPVHGYEYPTSGRRYGQTGICITFGYSQFEEIDFQLLVLQPNIYSCFIPSTF--HWKLIYMPRMCANSSSLKIPVRYLA-ELHSAQGLNFVHFAKSSFYTDDIFTGWIAQKLKTHLLAQTWQKKKQELPSNCSLPYHVYNIKSIGVTSKSYFSSRQDHSKWCVSIKGSANRWTCIGDLNRSLHQALRGGGFICTKNHYIYQAFHKLYLRYGFC 353
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Mouse
Match: Dnase2b (deoxyribonuclease II beta [Source:MGI Symbol;Acc:MGI:1913283])

HSP 1 Score: 192.586 bits (488), Expect = 1.503e-57
Identity = 111/351 (31.62%), Postives = 184/351 (52.42%), Query Frame = 2 
Query:   29 MKIIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPK---------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAY--YNDETPKFTYSSR--GHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESW-IRGEKVDSTCGTNYHVYNVEKVNLPG-AKFRESHDHSKWAVS-NNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            ++ +   L F +   L   E+SC+N+  + ++WFI  K PK           +++Y+ S  +TW  S + ++S  + +G T++  Y +H S +  AY  YND  P     SR  GH KG++ ++   GFWLIHSVP FP    Y Y  +   YGQ+ IC++      + I  QLL++Q  +YS  +P  F  + KL  +     N+ ++KI    +   + + + L  VHF KS  +  D+++G +A  L+  ++ ++W  + +++ S C   YHVYN++ + +   + F    DHSKW VS     + + CIGD+NR   Q  RGGG +C KN  I++ F  +   +  C
Sbjct:    6 LRTVLSLLFFALSGVLGTPEISCRNEYGEAVDWFIFYKLPKRTSKASEEAGLQYLYLDSTRQTWNKSLYLINSTRSALGRTLQHLYDTHNSTNDTAYLIYNDGVPGSVNYSRQYGHAKGLLVWNRTQGFWLIHSVPKFPPVHGYEYPTSGRRYGQTGICITFGYSQFEEIDFQLLVLQPNIYSCFIPSTF--HWKLIYMPRMCANSSSLKIPVRYLA-ELHSAQGLNFVHFAKSSFYTDDIFTGWIAQKLKTHLLAQTWQKKKQELPSNCSLPYHVYNIKSIGVTSKSYFSSRQDHSKWCVSIKGSANRWTCIGDLNRSLHQALRGGGFICTKNHYIYQAFHKLYLRYGFC 353
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Mouse
Match: Dnase2a (deoxyribonuclease II alpha [Source:MGI Symbol;Acc:MGI:1329019])

HSP 1 Score: 184.882 bits (468), Expect = 1.223e-54
Identity = 110/335 (32.84%), Postives = 165/335 (49.25%), Query Frame = 2 
Query:   89 LSCKNDNNQDIEWFIGLKFP---------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTYS----SRGHLKGVISFDINNGFWLIHSVPLFP---TFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPGAK---FRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            LSC  D+ Q ++WF+  K P         K   + Y+   S+ W      ++S    +G +++  Y  + SQ  +  YND+ PK + +      GH KGV+  D   GFWL+HSVP FP   + G YT+    + +GQ+ +CVSL       I  QL      VY + L E F    KL  L T  I N+++  +  N ++I+ +        F K   FG DLYSG +A  L  ++ V+ W     +  S C   Y V +V +   PG     F  + DHSKW V+     P+ C+GD+NR  ++  RGGGT+C +  + WK FQ +V D++ C
Sbjct:   20 LSCYGDSGQPVDWFVVYKLPAHSGSRDTPKGLTYKYMDQNSDGWQDGVGYINSSEGAVGRSLQPLYRKNSSQLAFLLYNDQPPKSSSARDSTGHGHTKGVLLLDQEGGFWLVHSVPRFPPPASSGAYTWPPNAQTFGQTLLCVSLPFTQFARIGKQLTYTYPLVYDHKL-EGF-FAQKLPDLET-VIKNQHVLHEPWNSSVILTSQAGATFQSFAKFGKFGDDLYSGWLAEALGTNLQVQFWQNSPGILPSNCSGAYQVLDVTQTGFPGPSRLTFSATEDHSKWCVAPQ--GPWACVGDMNRNKAETHRGGGTVCTQLPSFWKAFQSLVKDWKPC 349
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Mouse
Match: Dnase2a (deoxyribonuclease II alpha [Source:MGI Symbol;Acc:MGI:1329019])

HSP 1 Score: 172.17 bits (435), Expect = 4.802e-50
Identity = 102/307 (33.22%), Postives = 153/307 (49.84%), Query Frame = 2 
Query:  146 PKSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTYS----SRGHLKGVISFDINNGFWLIHSVPLFP---TFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPGAK---FRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            PK   + Y+   S+ W      ++S    +G +++  Y  + SQ  +  YND+ PK + +      GH KGV+  D   GFWL+HSVP FP   + G YT+    + +GQ+ +CVSL       I  QL      VY + L E F    KL  L T  I N+++  +  N ++I+ +        F K   FG DLYSG +A  L  ++ V+ W     +  S C   Y V +V +   PG     F  + DHSKW V+     P+ C+GD+NR  ++  RGGGT+C +  + WK FQ +V D++ C
Sbjct:   27 PKGLTYKYMDQNSDGWQDGVGYINSSEGAVGRSLQPLYRKNSSQLAFLLYNDQPPKSSSARDSTGHGHTKGVLLLDQEGGFWLVHSVPRFPPPASSGAYTWPPNAQTFGQTLLCVSLPFTQFARIGKQLTYTYPLVYDHKL-EGF-FAQKLPDLET-VIKNQHVLHEPWNSSVILTSQAGATFQSFAKFGKFGDDLYSGWLAEALGTNLQVQFWQNSPGILPSNCSGAYQVLDVTQTGFPGPSRLTFSATEDHSKWCVAPQ--GPWACVGDMNRNKAETHRGGGTVCTQLPSFWKAFQSLVKDWKPC 328
[Close]
BLAST of Deoxyribonuclease II family protein vs. UniProt/SwissProt
Match: sp|P34387|TG198_CAEEL (Cell-death-related nuclease 7 OS=Caenorhabditis elegans OX=6239 GN=crn-7 PE=2 SV=2)

HSP 1 Score: 233.417 bits (594), Expect = 2.724e-72
Identity = 122/346 (35.26%), Postives = 195/346 (56.36%), Query Frame = 2 
Query:   50 LIFNILHQLAICELSCKNDNNQDIEWFIGLKFPK-------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETP-KFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTN--------MTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWI--RGEKVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            LIF+++      ++ CKN   + ++WF+  K PK         +FVY  ++S  WT    D++  N  +G T+ Q YS+ +S +F+  Y+D+ P K   S RGH KGV  FD   GFWLIHSVP FP   +++Y    E YGQSF C S+E ++L  +      +Q+T Y  N+PE +          T F   KN++ +Q+         ++  +KT++ + L+ + K   F  D+++ L++   + ++ VESW+   G+ + +TC +    ++V ++ + G  F  S DHSKWAVSN+Q +P VC GD+NR  SQ KRGGG LC++N+N+W+++   V   E C
Sbjct:    7 LIFSVIFTTGNGKIQCKNMRGKSVDWFVVYKLPKLSGAGTSGKEFVYFDAESSDWTRGN-DINDPNVAVGATVSQVYSADKSNNFWFMYSDDDPIKSADSYRGHAKGVSLFDSTTGFWLIHSVPNFPPIKSFSYPNTAEKYGQSFFCASMEVQHLTELAEHWKYIQATPYIINIPEKYA---------TRFPTLKNVEAKQSLPRSATQFWISKPIKTVQGVTLMAYAKHKKFDGDIWNDLISRQNKVTLAVESWLNGSGDDIHTTCTSTSQTHDVTEMRVTGLNFASSKDHSKWAVSNSQTNPIVCFGDMNRQKSQLKRGGGALCIQNRNLWQLYHSFVIQVEPC 342
[Close]
BLAST of Deoxyribonuclease II family protein vs. UniProt/SwissProt
Match: sp|Q9QY48|DNS2B_MOUSE (Deoxyribonuclease-2-beta OS=Mus musculus OX=10090 GN=Dnase2b PE=2 SV=1)

HSP 1 Score: 192.586 bits (488), Expect = 1.051e-56
Identity = 111/351 (31.62%), Postives = 184/351 (52.42%), Query Frame = 2 
Query:   29 MKIIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPK---------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAY--YNDETPKFTYSSR--GHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESW-IRGEKVDSTCGTNYHVYNVEKVNLPG-AKFRESHDHSKWAVS-NNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            ++ +   L F +   L   E+SC+N+  + ++WFI  K PK           +++Y+ S  +TW  S + ++S  + +G T++  Y +H S +  AY  YND  P     SR  GH KG++ ++   GFWLIHSVP FP    Y Y  +   YGQ+ IC++      + I  QLL++Q  +YS  +P  F  + KL  +     N+ ++KI    +   + + + L  VHF KS  +  D+++G +A  L+  ++ ++W  + +++ S C   YHVYN++ + +   + F    DHSKW VS     + + CIGD+NR   Q  RGGG +C KN  I++ F  +   +  C
Sbjct:    6 LRTVLSLLFFALSGVLGTPEISCRNEYGEAVDWFIFYKLPKRTSKASEEAGLQYLYLDSTRQTWNKSLYLINSTRSALGRTLQHLYDTHNSTNDTAYLIYNDGVPGSVNYSRQYGHAKGLLVWNRTQGFWLIHSVPKFPPVHGYEYPTSGRRYGQTGICITFGYSQFEEIDFQLLVLQPNIYSCFIPSTF--HWKLIYMPRMCANSSSLKIPVRYLA-ELHSAQGLNFVHFAKSSFYTDDIFTGWIAQKLKTHLLAQTWQKKKQELPSNCSLPYHVYNIKSIGVTSKSYFSSRQDHSKWCVSIKGSANRWTCIGDLNRSLHQALRGGGFICTKNHYIYQAFHKLYLRYGFC 353
[Close]
BLAST of Deoxyribonuclease II family protein vs. UniProt/SwissProt
Match: sp|P34508|CRN6_CAEEL (Cell death-related nuclease 6 OS=Caenorhabditis elegans OX=6239 GN=crn-6 PE=2 SV=3)

HSP 1 Score: 186.037 bits (471), Expect = 5.348e-54
Identity = 115/360 (31.94%), Postives = 189/360 (52.50%), Query Frame = 2 
Query:   35 IIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPKSYK------------FVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTY--SSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIR--GEK--VDSTCGTNY--HVYNVEKVNLPGA-KFRESHDHSKWAVSNNQDS-----PYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCA 1036
            I Q+ LI +++  ++     CK++N  +++WF+  K P  +             F+Y    ++ W +    +  +NN + +T++Q Y+S+ + +F   YNDE P  T   +S GH KGV  FD   GFW+IHS+P FP+   + +      YGQ  IC+S  + +L  I  QL    +  Y +NLP++F     + + L N   NK+  +  T    ++K+L      HF K+  +G+DLYS  V P L++SI VE+W    G++  + S C  N+     + + + LP A  +    DHSK+ V+ ++ S     PYVCIGDINR + Q  RGGGT+C+ ++  +  F  I+++   C 
Sbjct:    2 IRQIILIVSLI-GISNAAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYFDVNNKNWKLMPQGMDVENNAVYYTLQQYYNSNMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTK---VLKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCT 357
[Close]
BLAST of Deoxyribonuclease II family protein vs. UniProt/SwissProt
Match: sp|Q17778|NUC1_CAEEL (Deoxyribonuclease-2 OS=Caenorhabditis elegans OX=6239 GN=nuc-1 PE=3 SV=1)

HSP 1 Score: 185.652 bits (470), Expect = 7.115e-54
Identity = 117/373 (31.37%), Postives = 174/373 (46.65%), Query Frame = 2 
Query:   44 VALIFNILH-QLAICELSCKNDNNQDIEWFIGLKFP------------KSYKFVYIS-SQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQS-FYAYYNDE--------------------------TPKFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKVDSTCGTNYHVYNVEKVNLPG-AKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCA 1036
              LIF +L         SCK+ +  D++WF   K P                + Y+  ++  T T S   L   +  I +T++Q Y     ++ F+  YNDE                              T ++ GH KG I FD  +G WL+HSVPLFP    Y Y  +   YGQ+ +C++ +   L++I  QL   +  +YS NLP N   ++     L   I  +  K Q     I ++T+      +F KS  F  DLY  LVAP L+  ++VE+W RG ++   C   YH  +   +++     F  + DHSK A S +   P+VCIGDINRMTSQ+ RGGGT C+ +  +WK +  ++A    CA
Sbjct:    7 AVLIFLLLGVSQTYAAFSCKDQSGNDVDWFAVYKMPIEKDDGSVTGLAGGVAWYYVDVNKKGTLTPSAKTLDDNDQAIAYTLQQYYDKQNDKTIFHVMYNDEPWGSKSTSGIKLEEILSNRVYSNYTHEDDSTSTAFGHTKGTIFFDGTSGVWLVHSVPLFPNPTKYEYPVSGHDYGQTMLCMTFKYAQLKSIGTQLFFNRPNIYSSNLPTNMAADN---ADLAKAIAGQYQKGQPFQSVIELETMAGYSFTNFAKSKEFNADLYDTLVAPTLKTDLVVETWRRGSEIPLDCKLTYHANDALSIHVGSTTAFSYTKDHSKMAHSADMTKPWVCIGDINRMTSQYVRGGGTTCISSSFLWKAYS-VIATQNNCA 375
[Close]
BLAST of Deoxyribonuclease II family protein vs. UniProt/SwissProt
Match: sp|O62855|DNS2A_PIG (Deoxyribonuclease-2-alpha OS=Sus scrofa OX=9823 GN=DNASE2 PE=1 SV=1)

HSP 1 Score: 185.267 bits (469), Expect = 7.737e-54
Identity = 107/341 (31.38%), Postives = 166/341 (48.68%), Query Frame = 2 
Query:   74 LAICELSCKNDNNQDIEWFIGLKFPK----------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFT----YSSRGHLKGVISFDINNGFWLIHSVPLFP---TFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPGAK---FRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            + +  L+C  D+ Q ++WF+  K P             ++ Y+  +S  W      ++S    +G ++   Y  + SQ  +  YND+ PK+      S+RGH KGV+  D   GFWLIHSVP FP   +   Y++  +   YGQ+ ICVS       NI  QL      VY Y L  +F    +    L   +   ++  +  N ++ + +        F K  +FG DLYSG +A  L +++ V+ W R   +  S C    HV +V ++  PG     F  + DHSKW V+   + P+ C+GD+NR   +  RGGGTLC +   +WK F+P+V  +E C
Sbjct:   15 VPVGTLTCYGDSGQPVDWFVVYKLPAHSSPGDVAQSGLRYKYLDEESGGWRDGAGSINSSTGALGRSLLPLYR-NTSQLAFLLYNDQPPKYRGSQHSSNRGHTKGVLLLDQEGGFWLIHSVPNFPPPSSSAAYSWPPSARTYGQTLICVSFPLTQFLNISRQLTYTYPMVYDYKLEGDF---ARKFPYLEEVVKGHHVLQEPWNSSVTLTSKAGASFQSFAKCGNFGDDLYSGWLAEALGSNLQVQFWQRSAGILPSNCSGVQHVLDVTQIAFPGPAGPNFNATEDHSKWCVA--PERPWTCVGDMNRNKREEHRGGGTLCAQLPALWKAFKPLVKAWEPC 349
[Close]
BLAST of Deoxyribonuclease II family protein vs. TrEMBL
Match: A0A016W8Z0 (Uncharacterized protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0986.g3296 PE=4 SV=1)

HSP 1 Score: 242.662 bits (618), Expect = 4.226e-73
Identity = 125/328 (38.11%), Postives = 184/328 (56.10%), Query Frame = 2 
Query:   83 CELSCKNDNNQDIEWFIGLKFP------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETP-KFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTII--MKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRG--EKVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
              L CKN N +D++WF  +K P      K   FVY  S  + W MS   + S  + IG TI Q Y   + ++F   YND++P K   S+RGH KGV +FD + GFW++HS+P FP    Y Y K+   + QS +C+SL +  L+++   +   Q T +  NLP++F V   +   L + +N K++    T  T I  ++TL       F K   FG DL+   +AP L+  + VE+W  G  + V + CG   +VY+V  VN+ G  F  ++DHSKW VS N+D P VCIGD+NR  SQ+KRGGG +C+++  +W+ F   V D+  C
Sbjct:   68 ARLGCKNMNGEDVDWFAAIKLPPGVDERKGKSFVYFDSTQDGWEMSPEAIDSNKSAIGATINQIYGIDKMRTFTIAYNDDSPVKAVDSNRGHSKGVAAFDNDVGFWMVHSIPNFPPLKKYDYPKSGTRFAQSLLCLSLSTNALEDVGQYMRFAQVTPFLSNLPDSFKV---VAPSLVDVVNKKSLSNSDTIFTTIRGLETLDGKRARGFSKHKKFGADLWYDFIAPNLKTPMAVETWRSGSGKDVGTKCGKKENVYDVNTVNILGKTFLNTNDHSKWGVSMNRDVPAVCIGDVNRQRSQYKRGGGAVCIEDVKLWETFHGSVGDYNGC 392
[Close]
BLAST of Deoxyribonuclease II family protein vs. TrEMBL
Match: A8XP82 (Protein CBR-CRN-7 OS=Caenorhabditis briggsae OX=6238 GN=crn-7 PE=4 SV=1)

HSP 1 Score: 241.506 bits (615), Expect = 5.213e-73
Identity = 130/352 (36.93%), Postives = 196/352 (55.68%), Query Frame = 2 
Query:   29 MKIIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPK------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETP-KFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTN--------MTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKVD--STCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            M  + V  IF ++  +   +  CKN   + ++WF+  K PK        +FVYI S+S  WT    D++  N  +G TI Q YSS ++ +F   Y+D+ P K   S RGH KGV  FD   GFWLIHSVP FP   +Y+Y K  E YGQSF C S+E ++L  +      +Q+T Y  NLP+ F          T F   +N++ +Q+         ++  +KT++ + L+ + K   F  D+++ L++   + ++ VESW+ G   D  +TC  +   ++V ++ + G  F  S DHSKWAVSN+Q +P VC GD+NR  SQ KRGGG LC++N+N+W+I+   V   E C
Sbjct:    1 MNRLLVVFIFTVIFSIGDGKFQCKNMRGKSVDWFVVYKLPKLSSGTTGKEFVYIDSESSVWTREN-DINDANVAVGATISQAYSSDKTNNFAFMYSDDDPIKEADSYRGHAKGVSLFDSTTGFWLIHSVPNFPPLTSYSYPKTAEKYGQSFFCASMEVQHLTELAEHWKYIQATPYLINLPDKFA---------TRFPTLRNVQAKQSLPRSATQFWISKPIKTVQGVTLMAYAKHKKFDGDIWNDLISKQNKVTLAVESWLNGSGDDLHTTCTDSSQTHDVTEMRVTGLNFASSKDHSKWAVSNSQTNPIVCFGDMNRQKSQLKRGGGALCIQNRNLWQIYHSSVIQVEPC 342
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BLAST of Deoxyribonuclease II family protein vs. TrEMBL
Match: A0A016W843 (Uncharacterized protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0986.g3296 PE=4 SV=1)

HSP 1 Score: 242.662 bits (618), Expect = 1.207e-72
Identity = 125/328 (38.11%), Postives = 184/328 (56.10%), Query Frame = 2 
Query:   83 CELSCKNDNNQDIEWFIGLKFP------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETP-KFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTII--MKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRG--EKVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
              L CKN N +D++WF  +K P      K   FVY  S  + W MS   + S  + IG TI Q Y   + ++F   YND++P K   S+RGH KGV +FD + GFW++HS+P FP    Y Y K+   + QS +C+SL +  L+++   +   Q T +  NLP++F V   +   L + +N K++    T  T I  ++TL       F K   FG DL+   +AP L+  + VE+W  G  + V + CG   +VY+V  VN+ G  F  ++DHSKW VS N+D P VCIGD+NR  SQ+KRGGG +C+++  +W+ F   V D+  C
Sbjct:   98 ARLGCKNMNGEDVDWFAAIKLPPGVDERKGKSFVYFDSTQDGWEMSPEAIDSNKSAIGATINQIYGIDKMRTFTIAYNDDSPVKAVDSNRGHSKGVAAFDNDVGFWMVHSIPNFPPLKKYDYPKSGTRFAQSLLCLSLSTNALEDVGQYMRFAQVTPFLSNLPDSFKV---VAPSLVDVVNKKSLSNSDTIFTTIRGLETLDGKRARGFSKHKKFGADLWYDFIAPNLKTPMAVETWRSGSGKDVGTKCGKKENVYDVNTVNILGKTFLNTNDHSKWGVSMNRDVPAVCIGDVNRQRSQYKRGGGAVCIEDVKLWETFHGSVGDYNGC 422
[Close]
BLAST of Deoxyribonuclease II family protein vs. TrEMBL
Match: A0A016W9R4 (Uncharacterized protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0986.g3296 PE=4 SV=1)

HSP 1 Score: 242.276 bits (617), Expect = 1.247e-71
Identity = 125/328 (38.11%), Postives = 184/328 (56.10%), Query Frame = 2 
Query:   83 CELSCKNDNNQDIEWFIGLKFP------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETP-KFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTII--MKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRG--EKVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
              L CKN N +D++WF  +K P      K   FVY  S  + W MS   + S  + IG TI Q Y   + ++F   YND++P K   S+RGH KGV +FD + GFW++HS+P FP    Y Y K+   + QS +C+SL +  L+++   +   Q T +  NLP++F V   +   L + +N K++    T  T I  ++TL       F K   FG DL+   +AP L+  + VE+W  G  + V + CG   +VY+V  VN+ G  F  ++DHSKW VS N+D P VCIGD+NR  SQ+KRGGG +C+++  +W+ F   V D+  C
Sbjct:  177 ARLGCKNMNGEDVDWFAAIKLPPGVDERKGKSFVYFDSTQDGWEMSPEAIDSNKSAIGATINQIYGIDKMRTFTIAYNDDSPVKAVDSNRGHSKGVAAFDNDVGFWMVHSIPNFPPLKKYDYPKSGTRFAQSLLCLSLSTNALEDVGQYMRFAQVTPFLSNLPDSFKV---VAPSLVDVVNKKSLSNSDTIFTTIRGLETLDGKRARGFSKHKKFGADLWYDFIAPNLKTPMAVETWRSGSGKDVGTKCGKKENVYDVNTVNILGKTFLNTNDHSKWGVSMNRDVPAVCIGDVNRQRSQYKRGGGAVCIEDVKLWETFHGSVGDYNGC 501
[Close]
BLAST of Deoxyribonuclease II family protein vs. TrEMBL
Match: A0A368FC76 (Deoxyribonuclease II OS=Ancylostoma caninum OX=29170 GN=ANCCAN_24471 PE=4 SV=1)

HSP 1 Score: 237.269 bits (604), Expect = 1.268e-71
Identity = 126/342 (36.84%), Postives = 187/342 (54.68%), Query Frame = 2 
Query:   41 QVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFP------KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETP-KFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMK--TLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRG--EKVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            ++ L F +       +L CKN   +D++WF  +K P      K   FVY  S  + W MS   + SK + IG TI Q Y   + ++F   YND++P K   S RGH KGV +FD + GFW++HSVP FP    Y Y ++   + QSF+C+SL +  L+++   +   Q T +  +LP +F V   +   L + +N K++    T+ T I K  TL       F K   FG DL+   +AP L+ S+ VE+W  G  + V +TCG   +VY++  V +  A +  S DHSKW VS  +  P VCIGD+NR  SQ+KRGGG +C+++  +WK F   +  +E C
Sbjct:    3 RLCLAFVVFINHGNAKLGCKNMQGEDVDWFAAIKLPPGVDKRKGTSFVYFDSTQDGWKMSPQSIDSKKSAIGATINQIYKVDKRKTFTIAYNDDSPVKAVDSGRGHSKGVAAFDSDVGFWMVHSVPNFPPIKKYKYPESGTRFAQSFLCLSLSTNALEDVGQYMRFAQVTPFLSSLPASFRV---VAPSLVDVVNKKSLSKSSTDFTTIRKMVTLDGKKAKGFAKGKRFGADLWYKFIAPNLKTSMAVETWRNGNAKNVGTTCGEKENVYDISVVKVLNATYPSSTDHSKWGVSMRETVPAVCIGDVNRQVSQYKRGGGAVCIEDLKLWKTFHKSIGKYEDC 341
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Cavefish
Match: dnase2b (deoxyribonuclease 2 beta [Source:NCBI gene;Acc:103030372])

HSP 1 Score: 191.815 bits (486), Expect = 2.678e-57
Identity = 109/334 (32.63%), Postives = 174/334 (52.10%), Query Frame = 2 
Query:   74 LAICELSCKNDNNQDIEWFIGLKFPKSYK--------FVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQS-QSFYAYYNDETPKFTYSSR-GHLKGVISFDINNGFWLIHSVPLFPTF--GNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIR-GEKVDSTCGTNYHVYNVEKVNLP-GAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            L+   LSC N+  Q ++WFI  K PK  K        ++Y+ +   TW MS + +++ +  +G T+ + Y +++S  S Y  YND  P   Y S  GH KG + FD + GFW+ HS+P FP F    + Y    ++YGQ+  C +   E  + I  QL  +   VY+ ++P   P +  +  +       K   +        +K+      + F KS+ +  D+Y+G VA  L+  ++VESW R   ++ S C   YHV N+++V+LP    F    DHSKW VS    + + C+GD+NR ++Q  RGGG +C +N  ++K F+  VA F+ C
Sbjct:   35 LSEANLSCLNEEGQPVDWFIMYKLPKYKKGEVGSGVEYMYLDASMLTWRMSPYAVNTSDGAVGRTLGRLYKTYKSNSSVYMLYNDAPPLLKYQSNYGHSKGTLLFDRSQGFWITHSIPHFPPFLEMGFGYPSTGKLYGQTVHCTTYSYEQFKKISQQLAYINPRVYNCSVP--VPYHTDMAAM-AQLCGGKRPTVAPRRKLEKLKSALGETFLSFSKSHQYVDDIYAGWVAQTLRTDLLVESWQRDNHQLPSNCSLPYHVLNIKRVHLPENITFSSYEDHSKWCVSVEFRAQWTCLGDLNRESTQAYRGGGLICSQNPVVYKAFRQAVAWFKGC 365
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Cavefish
Match: dnase2 (deoxyribonuclease-2-alpha-like [Source:NCBI gene;Acc:103028211])

HSP 1 Score: 182.956 bits (463), Expect = 9.473e-54
Identity = 110/342 (32.16%), Postives = 171/342 (50.00%), Query Frame = 2 
Query:   89 LSCKNDNNQDIEWFIGLKFPKSY--------KFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKF-----TYSSRGHLKGVISFDINNGFWLIHSVPLFP---TFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVN-------DKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPGAK--FRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCA 1036
            LSC +D    ++WF   K P+ +        K++    +SE W      +   +  +G T+   Y   + +  Y  YND+ P+       + S GH KGV+ FD   GFWL+HS P FP   T G ++Y ++    GQ+FICV+   +  + I  QL + Q  VY  ++PE+   +        K      N  N         N ++ + +L     + F K  +F  DLY   VAP LQA ++V+ W R   + +S C  +Y V N++ ++ PG K  F+ + DHSKWA S + D  +VC+GDINR  ++ KRGGGT+C KN  +WK ++      + C+
Sbjct:   20 LSCYDDQGNTVDWFYLYKLPRPHEAPREEGLKYLLQEEKSEGWVDGSVLVEDTSGALGRTVGPLY--EEGELGYILYNDQPPEKDRLENAHRSAGHTKGVVLFDDKQGFWLVHSTPHFPPLKTEGKFSYPESGTQNGQNFICVTYPLDRFETIGEQLKINQPHVYDCHIPESLASSVPSMVNLCKENQHRRNSSNAPPPSYSSANRSVSLLSLGGKEFISFAKGAAFDNDLYHSWVAPALQADLLVQFWRRSTGILESDCDPSYKVLNIQLLS-PGQKLTFKSTEDHSKWAASVSGD--WVCVGDINRNEAEEKRGGGTVCHKNAVVWKAYRATALQCDSCS 356
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Sea Lamprey
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:ZDB-GENE-010724-16])

HSP 1 Score: 186.422 bits (472), Expect = 4.453e-56
Identity = 108/330 (32.73%), Postives = 164/330 (49.70%), Query Frame = 2 
Query:   89 LSCKNDNNQDIEWFIGLKFPKSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQS---FYAYYNDETPKFTY--SSRGHLKGVISFDINNGFWLIHSVPLFPTF--GNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSF---GQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPG-AKFRESHDHSKWAVSNNQDSP---YVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            +SC N   + ++WFI  K PK   ++Y+   +++W  ++ D+ S ++ +  T+ Q Y  + +++    +  YNDE P   +  S  GH KGV+  D   GFWL+HS P FP    G + +      YGQSF+CVS   +   +I +QL   +   YS  +     + DKL  L       K ++++     + + +        F K++ F     DLY  LVAP L++S+ +ESW+ G  V DS C   + V  V  ++LP  A F    DHSKW VS    SP   + C+GDINR   +  RGGGT+C  +  IW  F       E C
Sbjct:    1 VSCLNGEGKSVDWFIVYKLPKGKDYLYLDKSTQSWQNAQVDVDSNSSPVYQTVNQLYDGNATEAGDVAFVLYNDEPPNSPHYDSICGHTKGVVMLDGTGGFWLVHSTPHFPPSVPGPFAWPHTALRYGQSFLCVSYGFDQFGDIALQLRYNEPDHYSCQVGAQ--LKDKLPDLQALCAKTK-LQVESATRVVELTSSAGKTFRSFAKTHRFDDGASDLYVHLVAPNLKSSLYLESWVHGVGVFDSNCSGEFCVCRVSSISLPSVAPFSSEEDHSKWCVSQTGGSPGGAWACVGDINRNRGEEYRGGGTVCTDDPAIWAAFAKATTSVEPC 327
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Medaka
Match: dnase2 (deoxyribonuclease 2, lysosomal [Source:NCBI gene;Acc:101162954])

HSP 1 Score: 193.741 bits (491), Expect = 5.965e-58
Identity = 115/350 (32.86%), Postives = 179/350 (51.14%), Query Frame = 2 
Query:   86 ELSCKNDNNQDIEWFIGLKFPKSYK---------FVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSF-YAYYNDETPKFTYS-----SRGHLKGVISFDINNGFWLIHSVPLFPT---FGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENF----PVNDKL--KTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKV-DSTCGTNYHVYNVEKVNLPGA--KFRESHDHSKWAVSNNQ-----DSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCAN 1039
            ++SC ND    ++WF   K PK ++         ++ +    E W   K  ++  +  +G T+ Q YS  +S    Y  YND++P   +      S GH KGV+  D N GFWL+HS P FP     G Y Y  +    GQ+F+CV+   ++ Q I  QL + Q  VY  ++PE+     P    L  K  L++ ++++ M    +N ++ + ++     + F K  SF  DLY G VAP LQ+ ++V+ WIR   +  S C   + V ++  +N PG    F+ S DHSKWAVS  Q        +VC+GDINR  ++ KRGGGT+C+++  +WK ++      E C  
Sbjct:   19 QISCYNDQGDAVDWFYIYKLPKEHQKTAPRRGEQYLLLEKGGEGWMEGKVTVNDSSGALGRTVGQLYSERKSSEVAYVLYNDQSPVDGFGDGSGNSGGHTKGVVLLDQNQGFWLVHSTPHFPPERQAGEYYYPSSGVNNGQNFLCVTYPLKSFQTIGEQLQINQPHVYDCDIPESMVSLVPALAALCKKARLSDEVSSRPM----SNRSMTLTSMDGTNFISFAKGASFDDDLYHGWVAPALQSDLLVQFWIRSTGILPSDCSLGWKVLDITLIN-PGQTFAFKNSQDHSKWAVSPKQAWGGKGGGWVCVGDINRNEAEEKRGGGTVCLQDPVVWKAYRSAALQCEACGG 363
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Medaka
Match: dnase2b (deoxyribonuclease-2-beta [Source:NCBI gene;Acc:101174093])

HSP 1 Score: 175.252 bits (443), Expect = 6.063e-51
Identity = 107/349 (30.66%), Postives = 172/349 (49.28%), Query Frame = 2 
Query:   41 QVALIFNILHQLAIC--ELSCKNDNNQDIEWFIGLKFPK--------SYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTY---SSHQSQSFYAYYNDETPKFTY-SSRGHLKGVISFDINNGFWLIHSVPLFPTFG--NYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESW-IRGEKVDSTCGTNYHVYNVEKVNLPG-AKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            Q+AL+   L    +C  ++SC+N+    ++WFI  K PK          +++Y+      W MSK+ +++    I  T++Q Y   +   + S Y  YND  P   Y  + GH KGV+ FD   GFWL HS+P FP+F    Y Y  + ++ GQ+ +C++ +      I  QL  +    Y+ ++P     +  L  L      +K       +M  +    +    + F KS  F  D+Y+G VA  L   ++VESW  +G  + S C    H  N++++ LP   +F+  +DHSKW VS   +    C+GD+NR  +Q  RGGG +C  N  I+K F+ +V  +  C
Sbjct:   10 QIALL---LFTCLVCAADISCRNEEGNPVDWFIIYKLPKYKVGEVGSGVEYMYLDESVARWQMSKYMINTSQGAIANTLKQLYMGKAYMSNSSVYVLYNDGPPDLKYIQAYGHTKGVLLFDHAKGFWLSHSIPHFPSFPERGYLYPSSGKLNGQTLLCMTYQYAQFLKIAQQLEYLYPRFYNCSVPAALSAD--LPQLAKLCAGSKPALASDKSMQPLFSN-RGEKFISFVKSDHFVDDIYTGWVAQVLDTDLLVESWQTQGRVLPSNCSLPRHAMNIKRIQLPTLVRFQSYYDHSKWCVSQAYEDQVTCLGDLNRERAQLWRGGGLICSDNPVIYKAFRQLVDWYISC 352
[Close]
BLAST of Deoxyribonuclease II family protein vs. Ensembl Medaka
Match: ENSORLT00000036979.1 (deoxyribonuclease-2-alpha [Source:NCBI gene;Acc:101173852])

HSP 1 Score: 163.696 bits (413), Expect = 1.349e-46
Identity = 98/346 (28.32%), Postives = 181/346 (52.31%), Query Frame = 2 
Query:   35 IIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPKSYK----FVYISSQSETWTMSKFDLSSKNNMIGWTIEQ--TYSSHQSQSF-YAYYNDETPK--FTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTY-GKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIR-GEKVDSTCGTN--YHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            +I+V +   I       ++ C+ND+  +++W+I  K   + K    ++Y+   +  WT+S   + S++  +GWT++    +   Q++ F Y  YND+ P       S GH KGV+  D   G WL HS P FPT+ +  +  ++     Q+F+C++      + I +QL  + +  +  ++P+ F +  +     + +   K    +  N+    K++     + F K   F  DLYSGL+   L +++ V+SW +  + + S C ++  +HVYNV+ V L    F ++ DHSKW V+++++  + C+ D+NR TSQ  RGGG LC+ +  + K F+  ++ +E C
Sbjct:    6 LIKVLVSVGIFFHGCQSDVRCRNDHGVEVDWYILYKLRNTQKDGSSYLYMDENTNGWTVSNQKIDSRSGCLGWTLKPLLDFYVKQTEGFGYLLYNDQPPNPYVAPKSFGHSKGVVMLDRQTGVWLSHSTPRFPTYRSQNFWPESGNANAQAFMCITFPYAQFEAIGLQLKYIHAYSFDSHVPQVFHMELQCVAQRSCY-PKKEPWFKVANL----KSMGGHSFLSFAKYTRFKDDLYSGLITNTLPSNLYVKSWGKMHDSLASNCSSSIPHHVYNVKTVKLLKRDFNDTVDHSKWCVTSDEN--WTCVADMNRETSQMGRGGGALCMDSYEVAKAFRSTISAYEPC 344
[Close]
BLAST of Deoxyribonuclease II family protein vs. Planmine SMEST
Match: SMESG000062993.1 (SMESG000062993.1)

HSP 1 Score: 715.687 bits (1846), Expect = 0.000e+0
Identity = 345/348 (99.14%), Postives = 347/348 (99.71%), Query Frame = 2 
Query:   29 MKIIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPKSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCANFLPVFHLKSIL 1072
            MKIIQVALIFNILHQLAICELSCKN+NNQDIEWFIGLKFPKSYKFVYISSQSETWT SKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKVDSTCGT+YHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCANFLPVFHLKSIL
Sbjct:    1 MKIIQVALIFNILHQLAICELSCKNENNQDIEWFIGLKFPKSYKFVYISSQSETWTTSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGEKVDSTCGTDYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCANFLPVFHLKSIL 348
[Close]
BLAST of Deoxyribonuclease II family protein vs. Planmine SMEST
Match: SMESG000062594.1 (SMESG000062594.1)

HSP 1 Score: 315.464 bits (807), Expect = 8.627e-106
Identity = 156/324 (48.15%), Postives = 219/324 (67.59%), Query Frame = 2 
Query:   77 AICELSCKNDNNQDIEWFIGLKFPKSYKFVYISSQSET--WTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTYSSRG-HLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWI--RGEKVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
             +CE++C+N+NN+ ++WF+ +K PKSY FVY+SS +    W  S +DL S+ N+I  T++Q+Y    ++ FY YYND+ P    S++G HLKG+++ D + G+WL HSVP FP    Y + KA+ IYGQSF+CVS+++  L+ IV QLL+MQ+TVYS   P +F  + +L +LL   I N   K   +N+ +  KTL S+ L+HF KS  + QDLYS L+AP L  S+ VE+W   RG K+DS C   Y V NVE++NL    F+ + DHSKWA+S ++ SPY+CIGDINRM SQFKRGGG+LC  N NIW+ F   +  +EKC
Sbjct:   20 TLCEITCRNENNEYLDWFVAIKHPKSYNFVYLSSANADSHWKESNYDLKSEKNLIAITLQQSYLHCNTKCFYIYYNDDRPLSNSSTKGGHLKGILNMDDSTGYWLTHSVPNFPMENEYFFNKAQSIYGQSFMCVSIKNTYLKPIVQQLLMMQATVYSSFYPTSFTNDMELISLLPRLIKNIRSKNLVSNI-LHFKTLNSMNLLHFAKSPKYDQDLYSKLIAPTLNGSLFVETWRNGRGSKLDSACELKYKVNNVEEINLSNKSFKSTSDHSKWAISQSKSSPYICIGDINRMESQFKRGGGSLCTSNVNIWEKFYKSIKTYEKC 342
[Close]
BLAST of Deoxyribonuclease II family protein vs. Planmine SMEST
Match: SMESG000081036.1 (SMESG000081036.1)

HSP 1 Score: 294.664 bits (753), Expect = 1.400e-97
Identity = 147/342 (42.98%), Postives = 218/342 (63.74%), Query Frame = 2 
Query:   29 MKIIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPKSYKFVYISSQSE--TWTMSKFDLSSKNNMIGWTIEQTYSS--HQSQSFYAYYNDETPK-FTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGE--KVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            +K+I   L+  I  Q  + ++ CK++ N D++W+I +K+P  Y F Y+SS++   TW +  + L+S  N++  T+ Q YS+  ++ ++FYA+YND+  K  + S+ GHLKGVI+FD   G+WLIHSVP FP    Y+Y   + I GQSFICVS+++ +L ++V QLLLM + VYSY  P +F  N  L   L   ++N +    ++N+ I + T+  +PL+HFGKS  F  DLYS L+AP L+ S+ VESW+ G   +  S C   Y VYN++ V + G +  +  DHSKWAV+ +  +   CIGDINRM SQF RGGG+LC  + N+W  F   V+D+EKC
Sbjct:    2 LKLILGILVIAISFQQHLAKIMCKSEKNSDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAENNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNV-IHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHANVWSAFNKAVSDYEKC 342
[Close]
BLAST of Deoxyribonuclease II family protein vs. Planmine SMEST
Match: SMESG000081036.1 (SMESG000081036.1)

HSP 1 Score: 286.96 bits (733), Expect = 6.279e-95
Identity = 142/320 (44.38%), Postives = 207/320 (64.69%), Query Frame = 2 
Query:   95 CKNDNNQDIEWFIGLKFPKSYKFVYISSQSE--TWTMSKFDLSSKNNMIGWTIEQTYSS--HQSQSFYAYYNDETPK-FTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGE--KVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKC 1033
            CK++ N D++W+I +K+P  Y F Y+SS++   TW +  + L+S  N++  T+ Q YS+  ++ ++FYA+YND+  K  + S+ GHLKGVI+FD   G+WLIHSVP FP    Y+Y   + I GQSFICVS+++ +L ++V QLLLM + VYSY  P +F  N  L   L   ++N +    ++N+ I + T+  +PL+HFGKS  F  DLYS L+AP L+ S+ VESW+ G   +  S C   Y VYN++ V + G +  +  DHSKWAV+ +  +   CIGDINRM SQF RGGG+LC  + N+W  F   V+D+EKC
Sbjct:    2 CKSEKNSDLDWYIAIKYPGVYNFFYLSSETNGNTWKLPNYALNSDKNLVALTLSQAYSAENNKDKTFYAFYNDDKSKNVSGSNDGHLKGVINFDEETGYWLIHSVPHFPPVRGYSYPDPQHINGQSFICVSIKTSDLNDVVKQLLLMYARVYSYYFPRSFTANTTLDYNLGRLVHNMHSPSIKSNV-IHLNTISKVPLIHFGKSKLFANDLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHANVWSAFNKAVSDYEKC 320
[Close]
BLAST of Deoxyribonuclease II family protein vs. Planmine SMEST
Match: SMESG000081051.1 (SMESG000081051.1)

HSP 1 Score: 171.4 bits (433), Expect = 3.858e-51
Identity = 98/231 (42.42%), Postives = 142/231 (61.47%), Query Frame = 2 
Query:   23 FRMKIIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFP--KSYKFVYISSQSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDE-TPKFTYSSRGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLESENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQTNMTIIMKTLKSLPLVHFGKSYSFGQ 706
            F +K I + L+  I  +++   LSCKN+NN+D++WFI +K P   S+  +   S +  W +S + L++ NN I  TI+QTY S   Q FY YYNDE T      + GH KGV++FD + G+WL+HSVP FP    Y YG  +  +GQSFICVSL+ +NL ++V QLL+M + VYSY +PE F  N  L   + + +NN   K + +N+     T+K+  L+HFGKS  F +
Sbjct:    3 FTLKFIILFLLVEI--KISKSSLSCKNENNEDVDWFIAIKPPHVDSFSSLSSQSNNTDWLLSSYKLTNGNNSIALTIKQTYESKLKQRFYVYYNDEDTAGNEKYNMGHSKGVVTFDKSEGYWLVHSVPKFPFPNEYKYGSGQLKFGQSFICVSLKFQNLNSLVDQLLIMTTNVYSYFVPEGFSQNSSLMDKINSLVNNSIKKSKDSNV-FNFNTVKNFNLIHFGKSRLFNR 230
The following BLAST results are available for this feature:
BLAST of Deoxyribonuclease II family protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
DNASE22.043e-5430.42deoxyribonuclease 2, lysosomal [Source:HGNC Symbol... [more]
DNASE2B1.432e-4830.84deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:H... [more]
DNASE2B5.188e-2132.12deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:H... [more]
DNASE21.263e-821.57deoxyribonuclease 2, lysosomal [Source:HGNC Symbol... [more]
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
crn-72.142e-7335.26Cell-death-related nuclease 7 [Source:UniProtKB/S... [more]
crn-64.205e-5531.94Cell death-related nuclease 6 [Source:UniProtKB/S... [more]
crn-64.205e-5531.94Cell death-related nuclease 6 [Source:UniProtKB/S... [more]
crn-64.587e-5531.94Cell death-related nuclease 6 [Source:UniProtKB/S... [more]
crn-64.587e-5531.94Cell death-related nuclease 6 [Source:UniProtKB/S... [more]
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
DNaseII2.292e-5231.70gene:FBgn0000477 transcript:FBtr0083538[more]
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
dnase2b1.901e-5633.43deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GEN... [more]
dnase2b2.303e-5332.66deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GEN... [more]
dnase29.163e-5131.64deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:Z... [more]
dnase29.163e-5131.64deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:Z... [more]
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dnase2b2.750e-6030.95deoxyribonuclease II beta [Source:NCBI gene;Acc:49... [more]
dnase21.176e-4931.25deoxyribonuclease II, lysosomal [Source:NCBI gene;... [more]
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Dnase2b1.503e-5731.62deoxyribonuclease II beta [Source:MGI Symbol;Acc:M... [more]
Dnase2b1.503e-5731.62deoxyribonuclease II beta [Source:MGI Symbol;Acc:M... [more]
Dnase2a1.223e-5432.84deoxyribonuclease II alpha [Source:MGI Symbol;Acc:... [more]
Dnase2a4.802e-5033.22deoxyribonuclease II alpha [Source:MGI Symbol;Acc:... [more]
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BLAST of Deoxyribonuclease II family protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P34387|TG198_CAEEL2.724e-7235.26Cell-death-related nuclease 7 OS=Caenorhabditis el... [more]
sp|Q9QY48|DNS2B_MOUSE1.051e-5631.62Deoxyribonuclease-2-beta OS=Mus musculus OX=10090 ... [more]
sp|P34508|CRN6_CAEEL5.348e-5431.94Cell death-related nuclease 6 OS=Caenorhabditis el... [more]
sp|Q17778|NUC1_CAEEL7.115e-5431.37Deoxyribonuclease-2 OS=Caenorhabditis elegans OX=6... [more]
sp|O62855|DNS2A_PIG7.737e-5431.38Deoxyribonuclease-2-alpha OS=Sus scrofa OX=9823 GN... [more]
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BLAST of Deoxyribonuclease II family protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A016W8Z04.226e-7338.11Uncharacterized protein OS=Ancylostoma ceylanicum ... [more]
A8XP825.213e-7336.93Protein CBR-CRN-7 OS=Caenorhabditis briggsae OX=62... [more]
A0A016W8431.207e-7238.11Uncharacterized protein OS=Ancylostoma ceylanicum ... [more]
A0A016W9R41.247e-7138.11Uncharacterized protein OS=Ancylostoma ceylanicum ... [more]
A0A368FC761.268e-7136.84Deoxyribonuclease II OS=Ancylostoma caninum OX=291... [more]
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dnase2b2.678e-5732.63deoxyribonuclease 2 beta [Source:NCBI gene;Acc:103... [more]
dnase29.473e-5432.16deoxyribonuclease-2-alpha-like [Source:NCBI gene;A... [more]
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
dnase24.453e-5632.73deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:Z... [more]
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Deoxyribonuclease II family protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
dnase25.965e-5832.86deoxyribonuclease 2, lysosomal [Source:NCBI gene;A... [more]
dnase2b6.063e-5130.66deoxyribonuclease-2-beta [Source:NCBI gene;Acc:101... [more]
ENSORLT00000036979.11.349e-4628.32deoxyribonuclease-2-alpha [Source:NCBI gene;Acc:10... [more]
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BLAST of Deoxyribonuclease II family protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000062993.10.000e+099.14SMESG000062993.1[more]
SMESG000062594.18.627e-10648.15SMESG000062594.1[more]
SMESG000081036.11.400e-9742.98SMESG000081036.1[more]
SMESG000081036.16.279e-9544.38SMESG000081036.1[more]
SMESG000081051.13.858e-5142.42SMESG000081051.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30007970 ID=SMED30007970|Name=Deoxyribonuclease II family protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1163bp
ATGAAAGGATCAGTATTCTAAATTTAGAATGAAAATAATTCAAGTTGCAT
TAATATTTAACATTTTACATCAACTGGCTATATGTGAATTATCGTGTAAA
AATGACAACAATCAAGATATTGAATGGTTTATTGGACTAAAATTTCCAAA
ATCGTACAAATTTGTTTATATAAGTTCTCAATCAGAAACCTGGACAATGT
CCAAATTTGATTTATCTAGCAAAAATAATATGATTGGTTGGACAATTGAA
CAAACATACTCATCACATCAATCTCAATCATTTTATGCATATTATAATGA
TGAAACGCCAAAATTTACCTACTCCAGTAGGGGTCATTTAAAAGGTGTAA
TTAGTTTTGATATTAATAATGGGTTTTGGCTTATACATTCTGTTCCTCTA
TTTCCAACATTTGGTAATTATACATATGGGAAAGCGGAAGAAATATATGG
TCAGTCATTTATATGTGTTTCACTTGAATCTGAAAATCTTCAGAATATTG
TAATTCAACTGCTGCTAATGCAATCAACTGTATATAGTTATAACCTTCCA
GAAAACTTTCCGGTAAATGATAAATTGAAGACTTTACTGACCAATTTCAT
TAATAATAAAAACATGAAAATCCAACAGACTAATATGACGATTATTATGA
AAACTCTGAAAAGTTTACCCTTGGTTCATTTTGGGAAATCTTATAGTTTT
GGTCAAGATTTGTATTCTGGGCTTGTTGCTCCTGGCTTACAAGCGTCTAT
TATGGTGGAAAGCTGGATTAGAGGAGAAAAAGTGGATTCAACTTGTGGCA
CCAATTACCATGTTTACAACGTTGAAAAAGTGAATTTACCAGGAGCAAAA
TTTCGTGAAAGCCATGATCATTCTAAATGGGCAGTTTCCAACAACCAAGA
CAGTCCGTACGTCTGCATCGGAGACATTAACAGAATGACAAGTCAATTCA
AAAGAGGAGGCGGAACTTTATGCGTTAAAAATAAGAATATTTGGAAAATC
TTTCAACCAATTGTAGCGGATTTTGAAAAATGCGCGAATTTTCTTCCAGT
TTTTCACCTAAAATCTATTTTATAATTATGTTAAGCTAAATAATATGAAT
TATTACTCTTGAATTTAACTGAAATATTATTGGTTGAAATATATATTTAT
AATATTAAAAAAA
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protein sequence of SMED30007970-orf-1

>SMED30007970-orf-1 ID=SMED30007970-orf-1|Name=SMED30007970-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=349bp
MKIIQVALIFNILHQLAICELSCKNDNNQDIEWFIGLKFPKSYKFVYISS
QSETWTMSKFDLSSKNNMIGWTIEQTYSSHQSQSFYAYYNDETPKFTYSS
RGHLKGVISFDINNGFWLIHSVPLFPTFGNYTYGKAEEIYGQSFICVSLE
SENLQNIVIQLLLMQSTVYSYNLPENFPVNDKLKTLLTNFINNKNMKIQQ
TNMTIIMKTLKSLPLVHFGKSYSFGQDLYSGLVAPGLQASIMVESWIRGE
KVDSTCGTNYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDI
NRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCANFLPVFHLKSIL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR004947DNase_II
Vocabulary: molecular function
TermDefinition
GO:0004531deoxyribonuclease II activity
Vocabulary: biological process
TermDefinition
GO:0006259DNA metabolic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR004947Deoxyribonuclease IIPFAMPF03265DNase_IIcoord: 22..335
e-value: 5.8E-94
score: 315.0
IPR004947Deoxyribonuclease IIPANTHERPTHR10858DEOXYRIBONUCLEASE IIcoord: 5..338
NoneNo IPR availablePANTHERPTHR10858:SF23DEOXYRIBONUCLEASE IIcoord: 5..338
NoneNo IPR availableCDDcd09120PLDc_DNaseII_1coord: 19..149
e-value: 5.88406E-45
score: 148.981
NoneNo IPR availableCDDcd09121PLDc_DNaseII_2coord: 202..335
e-value: 3.02878E-57
score: 180.507
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..19
score: 0.697