Iroquois-class homeodomain protein IRX-6

Overview


Name	Iroquois-class homeodomain protein IRX-6
Smed ID	SMED30007957
Length (bp)	1028

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Iroquois-class homeodomain protein IRX-6 (SMED30007957) t-SNE clustered cells

Violin plots show distribution of expression levels for Iroquois-class homeodomain protein IRX-6 (SMED30007957) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Iroquois-class homeodomain protein IRX-6 (SMED30007957) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Iroquois-class homeodomain protein IRX-6 (SMED30007957) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30007957

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30007957	SMESG000022899.1	dd_Smed_v4_14656_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30007957	SMESG000022899.1	dd_Smed_v4_14656_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30007957	SMESG000022899.1	dd_Smed_v4_14656_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30007957	SMESG000022899.1	dd_Smed_v4_14656_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30007957	SMESG000022899.1	dd_Smed_v6_14656_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
nervous system	SMED30007957	SMESG000022899.1	DN307336	ncbi_smed_ests	PMID:25356635 Cowles et al., 2014
neuron	SMED30007957	SMESG000022899.1	DN307336	ncbi_smed_ests	PMID:25356635 Cowles et al., 2014

Note: Hover over icons to view figure legend

Homology

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Human
Match: IRX1 (iroquois homeobox 1 [Source:HGNC Symbol;Acc:HGNC:14358])

HSP 1 Score: 119.013 bits (297), Expect = 2.564e-29
Identity = 72/150 (48.00%), Postives = 90/150 (60.00%), Query Frame = 3

Query:  462 NLNPITLAHLHTINHADVNQIQV-----KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSI-IDMISE-PSDCSHED 890
             ++P T A      +    Q Q       KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K        D E   LF  + E      +  ++  + SI ID I E   D S+ED
Sbjct:  103 GVHPATFAAHTAPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSK--------DQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQSNED 244

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Human
Match: IRX4 (iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6129])

HSP 1 Score: 116.701 bits (291), Expect = 2.041e-28
Identity = 51/63 (80.95%), Postives = 60/63 (95.24%), Query Frame = 3

Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            +KNATRE +STLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  146 RKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 208

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Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            +KNATRE +STLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  146 RKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 208

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Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            +KNATRE +STLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  146 RKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 208

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Human
Match: IRX4 (iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6129])

HSP 1 Score: 116.701 bits (291), Expect = 2.313e-28
Identity = 51/63 (80.95%), Postives = 60/63 (95.24%), Query Frame = 3

Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            +KNATRE +STLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  172 RKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 234

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Celegans
Match: irx-1 (Putative iroquois-class homeodomain protein irx-1 [Source:UniProtKB/Swiss-Prot;Acc:Q93348])

HSP 1 Score: 100.138 bits (248), Expect = 1.705e-23
Identity = 47/84 (55.95%), Postives = 63/84 (75.00%), Query Frame = 3

Query:  471 PITLAHLHTINHA-DVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            P+  +  H + H   ++ I+ K+NATRE ++ LK WL  H+ NPYPSK +K++LA+ T M+LTQVSTWFANARRRLKKENK+ W
Sbjct:   99 PMFFSDAHRLYHPYGLDGIK-KRNATREATAPLKDWLHSHRKNPYPSKADKVMLAVGTGMTLTQVSTWFANARRRLKKENKMTW 181

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Celegans
Match: ceh-60 (C. Elegans Homeobox [Source:UniProtKB/TrEMBL;Acc:Q45EK2])

HSP 1 Score: 49.6766 bits (117), Expect = 1.395e-6
Identity = 21/58 (36.21%), Postives = 34/58 (58.62%), Query Frame = 3

Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKE 704
            ++N  +  +  L+ W  +H+ NPYPS  EK  LA    + ++QV+ WF N R R K++
Sbjct:  184 RRNFDKNTTDILQNWFHDHRQNPYPSDQEKAELAKQCNIKISQVNNWFGNQRIRTKQQ 241

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Fly
Match: mirr (gene:FBgn0014343 transcript:FBtr0330077)

HSP 1 Score: 116.316 bits (290), Expect = 2.427e-28
Identity = 53/70 (75.71%), Postives = 63/70 (90.00%), Query Frame = 3

Query:  510 DVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            D+N  + +KNATRE +STLKAWL EHK NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  222 DLNGAR-RKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 290

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Fly
Match: mirr (gene:FBgn0014343 transcript:FBtr0075911)

HSP 1 Score: 116.316 bits (290), Expect = 2.482e-28
Identity = 53/70 (75.71%), Postives = 63/70 (90.00%), Query Frame = 3

Query:  510 DVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            D+N  + +KNATRE +STLKAWL EHK NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  222 DLNGAR-RKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 290

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Fly
Match: mirr (gene:FBgn0014343 transcript:FBtr0075912)

HSP 1 Score: 116.316 bits (290), Expect = 2.482e-28
Identity = 53/70 (75.71%), Postives = 63/70 (90.00%), Query Frame = 3

Query:  510 DVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            D+N  + +KNATRE +STLKAWL EHK NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  222 DLNGAR-RKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 290

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Fly
Match: caup (gene:FBgn0015919 transcript:FBtr0075909)

HSP 1 Score: 115.931 bits (289), Expect = 3.187e-28
Identity = 50/63 (79.37%), Postives = 60/63 (95.24%), Query Frame = 3

Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            +KNATRE+++TLKAWL EHK NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  230 RKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 292

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Fly
Match: ara (gene:FBgn0015904 transcript:FBtr0075908)

HSP 1 Score: 114.775 bits (286), Expect = 7.681e-28
Identity = 50/63 (79.37%), Postives = 60/63 (95.24%), Query Frame = 3

Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            +KNATRE+++TLKAWL EHK NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  259 RKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 321

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Zebrafish
Match: irx3b (iroquois homeobox 3b [Source:ZFIN;Acc:ZDB-GENE-030131-525])

HSP 1 Score: 119.013 bits (297), Expect = 1.985e-30
Identity = 65/123 (52.85%), Postives = 88/123 (71.54%), Query Frame = 3

Query:  534 KNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDS--TSDSELSELFTREYEKPNSNQKITKKNHIWSIIDM--ISEPSDCSHED 890
            KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W+   ++D   +  TSD+E       + EK + +++I  +N     ID   I +  DC ++D
Sbjct:  106 KNATRESTSTLKAWLSEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWVPKTRTDEDGNVYTSDNE-------DAEKRDEDEEIDLEN-----IDTEDIEDKQDCDYQD 216

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Zebrafish
Match: irx1a (iroquois homeobox 1a [Source:ZFIN;Acc:ZDB-GENE-040707-1])

HSP 1 Score: 119.013 bits (297), Expect = 6.702e-30
Identity = 64/129 (49.61%), Postives = 83/129 (64.34%), Query Frame = 3

Query:  402 IRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSD----NPDSTSDSELSE 776
            + SQ  L++    H A+ A + +P      +             KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K D      D+  D+E +E
Sbjct:   79 MGSQYDLKDSPGVHPASFAAHTSPA----FYPYGQFQYGDPARPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDDENIFGSDNEGDAEKNE 203

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Zebrafish
Match: irx1a (iroquois homeobox 1a [Source:ZFIN;Acc:ZDB-GENE-040707-1])

HSP 1 Score: 119.398 bits (298), Expect = 6.832e-30
Identity = 63/122 (51.64%), Postives = 80/122 (65.57%), Query Frame = 3

Query:  402 IRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSE 767
            + SQ  L++    H A+ A + +P      +             KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K D     SD+E
Sbjct:   79 MGSQYDLKDSPGVHPASFAAHTSPA----FYPYGQFQYGDPARPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDDENIFGSDNE 196

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Zebrafish
Match: irx4b (iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040712-4])

HSP 1 Score: 119.013 bits (297), Expect = 1.028e-29
Identity = 60/100 (60.00%), Postives = 71/100 (71.00%), Query Frame = 3

Query:  471 PITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGK-SDNPDSTSDSE 767
            PI         +  V+    +KNATRE +STLKAWLQEHK NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    K SD  +   D E
Sbjct:  123 PIGQYSYDRYGYGSVDVGTRRKNATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNKNSDEKECDDDQE 222

[Close]

Query:  471 PITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGK-SDNPDSTSDSE 767
            PI         +  V+    +KNATRE +STLKAWLQEHK NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    K SD  +   D E
Sbjct:  123 PIGQYSYDRYGYGSVDVGTRRKNATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNKNSDEKECDDDQE 222

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Xenopus
Match: smc1b (structural maintenance of chromosomes 1B [Source:Xenbase;Acc:XB-GENE-997265])

HSP 1 Score: 122.479 bits (306), Expect = 9.110e-31
Identity = 62/107 (57.94%), Postives = 76/107 (71.03%), Query Frame = 3

Query:  462 NLNPITLAHLHTINHADVNQIQV-----KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSE 767
             ++P T A   T  +    Q Q       KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K D+    SD+E
Sbjct:  102 GVHPATFAAHTTPGYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKEDDNIFGSDTE 208

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Xenopus
Match: fancm (FA complementation group M [Source:Xenbase;Acc:XB-GENE-994655])

HSP 1 Score: 117.472 bits (293), Expect = 5.393e-29
Identity = 52/75 (69.33%), Postives = 64/75 (85.33%), Query Frame = 3

Query:  513 VNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKS 737
            +N    +KNATR+ ++TLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    KS
Sbjct:  108 LNDPAYRKNATRDATATLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNKS 182

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Xenopus
Match: lypla1 (lysophospholipase 1 [Source:Xenbase;Acc:XB-GENE-942736])

HSP 1 Score: 116.701 bits (291), Expect = 6.263e-29
Identity = 52/76 (68.42%), Postives = 64/76 (84.21%), Query Frame = 3

Query:  510 DVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKS 737
            D++    +KNATREN+STLK WL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    K+
Sbjct:  139 DISCSSRRKNATRENTSTLKTWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPKNKA 214

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Xenopus
Match: fancm (FA complementation group M [Source:Xenbase;Acc:XB-GENE-994655])

HSP 1 Score: 117.087 bits (292), Expect = 9.542e-29
Identity = 52/75 (69.33%), Postives = 64/75 (85.33%), Query Frame = 3

Query:  513 VNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKS 737
            +N    +KNATR+ ++TLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    KS
Sbjct:  108 LNDPAYRKNATRDATATLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNKS 182

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Xenopus
Match: ndufaf5 (NADH:ubiquinone oxidoreductase complex assembly factor 5 [Source:Xenbase;Acc:XB-GENE-975960])

HSP 1 Score: 116.316 bits (290), Expect = 1.507e-28
Identity = 51/69 (73.91%), Postives = 62/69 (89.86%), Query Frame = 3

Query:  534 KNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSD 740
            KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    ++D
Sbjct:  113 KNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTD 181

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Mouse
Match: Irx1 (Iroquois homeobox 1 [Source:MGI Symbol;Acc:MGI:1197515])

HSP 1 Score: 120.553 bits (301), Expect = 1.444e-31
Identity = 73/150 (48.67%), Postives = 91/150 (60.67%), Query Frame = 3

Query:  462 NLNPITLAHLHTINHADVNQIQV-----KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSI-IDMISE-PSDCSHED 890
             ++P T A   T  +    Q Q       KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K        D E   LF  + E      +  ++  + SI ID I E   D S+ED
Sbjct:   18 GVHPATFAAHTTPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSK--------DQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQIDERDGDQSNED 159

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Mouse
Match: Irx2 (Iroquois homeobox 2 [Source:MGI Symbol;Acc:MGI:1197526])

HSP 1 Score: 112.464 bits (280), Expect = 1.583e-30
Identity = 51/75 (68.00%), Postives = 63/75 (84.00%), Query Frame = 3

Query:  513 VNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKS 737
            +N    +KNATR+ ++TLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    KS
Sbjct:   19 LNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNKS 93

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Mouse
Match: Irx1 (Iroquois homeobox 1 [Source:MGI Symbol;Acc:MGI:1197515])

HSP 1 Score: 120.939 bits (302), Expect = 2.993e-30
Identity = 73/150 (48.67%), Postives = 91/150 (60.67%), Query Frame = 3

Query:  462 NLNPITLAHLHTINHADVNQIQV-----KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSI-IDMISE-PSDCSHED 890
             ++P T A   T  +    Q Q       KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K        D E   LF  + E      +  ++  + SI ID I E   D S+ED
Sbjct:  103 GVHPATFAAHTTPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSK--------DQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQIDERDGDQSNED 244

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Mouse
Match: Irx4 (Iroquois homeobox 4 [Source:MGI Symbol;Acc:MGI:1355275])

HSP 1 Score: 118.242 bits (295), Expect = 4.259e-29
Identity = 52/72 (72.22%), Postives = 63/72 (87.50%), Query Frame = 3

Query:  504 HADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            +  V+    +KNATRE +STLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  138 YGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 209

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Query:  504 HADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            +  V+    +KNATRE +STLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:  138 YGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 209

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. UniProt/SwissProt
Match: sp|Q2TAQ8|IRX1B_XENLA (Iroquois-class homeodomain protein irx-1-B OS=Xenopus laevis OX=8355 GN=irx1-b PE=2 SV=1)

HSP 1 Score: 124.405 bits (311), Expect = 1.150e-30
Identity = 63/107 (58.88%), Postives = 77/107 (71.96%), Query Frame = 3

Query:  462 NLNPITLAHLHTINHADVNQIQV-----KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSE 767
             ++P T A   T  +    Q Q       KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A GK D+    SD+E
Sbjct:   97 GVHPATFAAHTTPGYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGAMGKEDDNIFGSDNE 203

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. UniProt/SwissProt
Match: sp|Q6F2E3|IRX1_XENTR (Iroquois-class homeodomain protein irx-1 OS=Xenopus tropicalis OX=8364 GN=irx1 PE=2 SV=1)

HSP 1 Score: 122.479 bits (306), Expect = 4.826e-30
Identity = 62/107 (57.94%), Postives = 76/107 (71.03%), Query Frame = 3

Query:  462 NLNPITLAHLHTINHADVNQIQV-----KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSE 767
             ++P T A   T  +    Q Q       KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K D+    SD+E
Sbjct:  102 GVHPATFAAHTTPGYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKEDDNIFGSDTE 208

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. UniProt/SwissProt
Match: sp|P81068|IRX1_MOUSE (Iroquois-class homeodomain protein IRX-1 OS=Mus musculus OX=10090 GN=Irx1 PE=1 SV=4)

HSP 1 Score: 120.939 bits (302), Expect = 2.094e-29
Identity = 73/150 (48.67%), Postives = 91/150 (60.67%), Query Frame = 3

Query:  462 NLNPITLAHLHTINHADVNQIQV-----KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSI-IDMISE-PSDCSHED 890
             ++P T A   T  +    Q Q       KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K        D E   LF  + E      +  ++  + SI ID I E   D S+ED
Sbjct:  103 GVHPATFAAHTTPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSK--------DQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQIDERDGDQSNED 244

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. UniProt/SwissProt
Match: sp|Q9YGK8|IRX1A_XENLA (Iroquois-class homeodomain protein irx-1-A OS=Xenopus laevis OX=8355 GN=irx1-a PE=2 SV=1)

HSP 1 Score: 120.553 bits (301), Expect = 2.398e-29
Identity = 58/99 (58.59%), Postives = 71/99 (71.72%), Query Frame = 3

Query:  462 NLNPITLAHLHTINHADVNQIQV-----KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDN 743
             ++P T A   T  +    Q Q       KNATRE++ TLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K D+
Sbjct:  102 GVHPATFAAHTTPGYYPYGQFQYGDPGRPKNATRESTGTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKEDD 200

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. UniProt/SwissProt
Match: sp|P78414|IRX1_HUMAN (Iroquois-class homeodomain protein IRX-1 OS=Homo sapiens OX=9606 GN=IRX1 PE=2 SV=3)

HSP 1 Score: 119.013 bits (297), Expect = 1.231e-28
Identity = 72/150 (48.00%), Postives = 90/150 (60.00%), Query Frame = 3

Query:  462 NLNPITLAHLHTINHADVNQIQV-----KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSI-IDMISE-PSDCSHED 890
             ++P T A      +    Q Q       KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K        D E   LF  + E      +  ++  + SI ID I E   D S+ED
Sbjct:  103 GVHPATFAAHTAPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSK--------DQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQSNED 244

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. TrEMBL
Match: A0A1I8IV93 (Homeobox domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 134.035 bits (336), Expect = 4.627e-33
Identity = 68/119 (57.14%), Postives = 84/119 (70.59%), Query Frame = 3

Query:  396 MDIRSQDVLENWRQFHQAALANNLNPITLA---HLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDN 743
            +D +++ + ENWRQF QAA   NL+P  LA          AD+   Q +KNATRE +  LKAWL EHK NPYP+KGEKI+LAI+T M+LTQVSTWFANARRRLKKENK+ W    + D+
Sbjct:   51 LDPQTESLAENWRQFQQAAQNYNLDPHLLAIYGGSFAAGRADLAG-QRRKNATRETTGVLKAWLNEHKKNPYPTKGEKIMLAIITTMTLTQVSTWFANARRRLKKENKMTWAPRNRGDD 168

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. TrEMBL
Match: A0A1I8J4E6 (Homeobox domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 130.183 bits (326), Expect = 6.231e-32
Identity = 67/110 (60.91%), Postives = 78/110 (70.91%), Query Frame = 3

Query:  423 ENWRQFHQAALANNLNPITLA---HLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDN 743
            ENWRQF QAA   NL+P  LA          AD+   Q +KNATRE +  LKAWL EHK NPYP+KGEKI+LAI+T M+LTQVSTWFANARRRLKKENK+ W    + D+
Sbjct:   25 ENWRQFQQAAQNYNLDPHLLAIYGGSFAAGRADLAG-QRRKNATRETTGVLKAWLNEHKKNPYPTKGEKIMLAIITTMTLTQVSTWFANARRRLKKENKMTWAPRNRGDD 133

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. TrEMBL
Match: A0A2H1CL68 (Homeobox domain protein OS=Fasciola hepatica OX=6192 GN=D915_04403 PE=4 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 2.363e-30
Identity = 64/103 (62.14%), Postives = 80/103 (77.67%), Query Frame = 3

Query:  414 DVLENWRQFHQAALANNLNPITLAHLHTINHA-DVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            D L+ W+QF QAA ANNL+P  LA   +     +++    +KNATRE +S LKAWL EH+ NPYP+KGEKI+LA++T+MSLTQVSTWFANARRRLKKENK+ W
Sbjct:  359 DNLDCWQQFQQAAYANNLDPHFLALYSSAGCPFELSGSSRRKNATRETTSMLKAWLNEHRKNPYPTKGEKIMLALITKMSLTQVSTWFANARRRLKKENKVTW 461

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. TrEMBL
Match: A0A433TYJ0 (Homeobox domain-containing protein (Fragment) OS=Elysia chlorotica OX=188477 GN=EGW08_005580 PE=4 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 2.426e-30
Identity = 69/142 (48.59%), Postives = 92/142 (64.79%), Query Frame = 3

Query:  306 YNCSRYGGIPPEHIILANKVTGFLA-MNDPNMDIRSQDVLENWRQFHQAALANNLNPITLA---HLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            Y    Y G P  ++ LA+  + F   +N P  D++  D  E+WR   Q       +P ++    +  T    D+N    +KNATREN++TLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:   62 YPTPPYSG-PQGYVPLASDPSAFYPPLNSP-YDLK--DPGESWRGIGQGPACYPYDPTSMPAYPYPSTYGGMDINSAARRKNATRENTNTLKAWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 199

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. TrEMBL
Match: A0A1S8WJU4 (Homeobox domain protein OS=Opisthorchis viverrini OX=6198 GN=X801_09474 PE=4 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 2.960e-30
Identity = 68/112 (60.71%), Postives = 85/112 (75.89%), Query Frame = 3

Query:  420 LENWRQFHQAALANNLNPITLAHLHTINHA-DVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDS 752
            L++W+QF QAA ANNL+P  LA       A +++    +KNATRE +S LKAWL EH+ NPYP+KGEKI+LAI+T+MSLTQVSTWFANARRRLKKE+KI W    ++  PDS
Sbjct:  267 LDSWQQFQQAAYANNLDPHLLALCGGTGCAFELSGNSRRKNATRETTSMLKAWLNEHRKNPYPTKGEKIMLAIVTKMSLTQVSTWFANARRRLKKESKITWGV--RTTAPDS 376

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Cavefish
Match: irx1a (iroquois homeobox 1 [Source:NCBI gene;Acc:103024684])

HSP 1 Score: 119.398 bits (298), Expect = 6.313e-30
Identity = 60/113 (53.10%), Postives = 76/113 (67.26%), Query Frame = 3

Query:  402 IRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSD 740
            + SQ  L++    H A+ A + +P      +             KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K D
Sbjct:   77 MGSQYELKDSPGVHPASFAAHTSPA----FYPYGQFQYGDPARPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKED 185

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Cavefish
Match: irx1a (iroquois homeobox 1 [Source:NCBI gene;Acc:103024684])

HSP 1 Score: 119.398 bits (298), Expect = 6.744e-30
Identity = 60/113 (53.10%), Postives = 76/113 (67.26%), Query Frame = 3

Query:  402 IRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSD 740
            + SQ  L++    H A+ A + +P      +             KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W A  K D
Sbjct:   77 MGSQYELKDSPGVHPASFAAHTSPA----FYPYGQFQYGDPARPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKED 185

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Cavefish
Match: irx4a (iroquois-class homeodomain protein irx-4 [Source:NCBI gene;Acc:103025323])

HSP 1 Score: 119.013 bits (297), Expect = 9.597e-30
Identity = 63/112 (56.25%), Postives = 77/112 (68.75%), Query Frame = 3

Query:  444 QAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGK-SDNPDSTSDSELSE 776
            QAA     +P TL       +  ++    +KNATRE +STLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    K SD      D E S+
Sbjct:  110 QAATYYPYDP-TLGQYQYDRYGSMDGGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCSDEKRYGEDEEGSQ 220

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Cavefish
Match: irx3b (iroquois homeobox 3 [Source:NCBI gene;Acc:103035229])

HSP 1 Score: 117.087 bits (292), Expect = 1.600e-29
Identity = 54/90 (60.00%), Postives = 66/90 (73.33%), Query Frame = 3

Query:  471 PITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSD 740
            P   A      H  +      KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    ++D
Sbjct:   80 PHAHAPFFPYGHYQLGDPSRPKNATRESTSTLKAWLSEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKTRTD 169

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Cavefish
Match: irx2a (iroquois homeobox 2 [Source:NCBI gene;Acc:103024999])

HSP 1 Score: 118.242 bits (295), Expect = 1.683e-29
Identity = 52/75 (69.33%), Postives = 64/75 (85.33%), Query Frame = 3

Query:  513 VNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKS 737
            +N    +KNATR+ ++TLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    KS
Sbjct:  101 LNDPTYRKNATRDATATLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWAPRSKS 175

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002620.1 (pep scaffold:Pmarinus_7.0:GL484724:8057:10194:-1 gene:ENSPMAG00000002391.1 transcript:ENSPMAT00000002620.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 114.775 bits (286), Expect = 1.797e-31
Identity = 52/100 (52.00%), Postives = 71/100 (71.00%), Query Frame = 3

Query:  438 FHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKS 737
            +H    A++     + + +      V     +KNATR+ ++TLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W+   +S
Sbjct:   10 YHPYGGASHPTLGPVGYPYGAGGCGVADPAFRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITRMTLTQVSTWFANARRRLKKENKMTWVTKARS 109

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Sea Lamprey
Match: mkxb (mohawk homeobox b [Source:ZFIN;Acc:ZDB-GENE-080513-2])

HSP 1 Score: 73.9442 bits (180), Expect = 1.368e-15
Identity = 34/70 (48.57%), Postives = 51/70 (72.86%), Query Frame = 3

Query:  519 QIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLK---KENKIGW 719
            +++ K+ A ++ +  LK WL +H+ NPYP+K EKILLA+ + M+L QVS WFANARRRLK   ++ ++ W
Sbjct:    1 RVRHKRQALQDMARPLKHWLYKHRHNPYPTKTEKILLALGSHMTLVQVSNWFANARRRLKNTVRQPELSW 70

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Sea Lamprey
Match: pknox2 (pbx/knotted 1 homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-031118-112])

HSP 1 Score: 48.1358 bits (113), Expect = 1.497e-6
Identity = 23/63 (36.51%), Postives = 43/63 (68.25%), Query Frame = 3

Query:  510 DVNQIQVKKNATRENSST-LKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRL 695
            D  + ++K+    ++++T +++WL +H  +PYP++ EK  +A  T ++L QV+ WF NARRR+
Sbjct:  254 DDKRARLKRGVLPKHATTVMRSWLFQHIVHPYPTEDEKRQIANQTNLTLLQVNNWFINARRRI 316

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Yeast
Match: TOS8 (Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication [Source:SGD;Acc:S000003064])

HSP 1 Score: 50.8322 bits (120), Expect = 1.002e-7
Identity = 24/54 (44.44%), Postives = 31/54 (57.41%), Query Frame = 3

Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRR 692
            + N  +   S L  WL EH +NPYP+  EK  L   T ++  Q+S WF NARRR
Sbjct:  198 RSNLPKATVSILNKWLHEHVNNPYPTVQEKRELLAKTGLTKLQISNWFINARRR 251

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Yeast
Match: CUP9 (Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000006098])

HSP 1 Score: 48.9062 bits (115), Expect = 3.815e-7
Identity = 23/54 (42.59%), Postives = 31/54 (57.41%), Query Frame = 3

Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRR 692
            + N  +E    L  WL  H +NPYP++ EK  L I T ++  Q+S WF N RRR
Sbjct:  166 RSNLPKETVQILNTWLLNHLNNPYPTQQEKRELLIKTGLTKIQLSNWFINVRRR 219

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Nematostella
Match: EDO41982 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2T4])

HSP 1 Score: 112.464 bits (280), Expect = 2.194e-31
Identity = 51/63 (80.95%), Postives = 59/63 (93.65%), Query Frame = 3

Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW 719
            +KNATRE +STLKAWL EH+ NPYP+KGEKI+LAILT+M+LTQVSTWFANARRRLKKENK+ W
Sbjct:    3 RKNATRETTSTLKAWLFEHRKNPYPTKGEKIMLAILTKMTLTQVSTWFANARRRLKKENKMTW 65

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Nematostella
Match: EDO41178 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S544])

HSP 1 Score: 51.2174 bits (121), Expect = 1.584e-8
Identity = 23/55 (41.82%), Postives = 35/55 (63.64%), Query Frame = 3

Query:  531 KKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRL 695
            + N  +++ + L+ WL EH+ N YPS+ EK  L+    +S+ QV  WF NARRR+
Sbjct:   20 RGNLPKDSVNVLRLWLWEHRFNAYPSEAEKQYLSKAANLSVLQVCNWFINARRRI 74

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Nematostella
Match: EDO36439 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIN3])

HSP 1 Score: 49.6766 bits (117), Expect = 6.029e-7
Identity = 22/44 (50.00%), Postives = 32/44 (72.73%), Query Frame = 3

Query:  564 LKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRL 695
            +KAWL +H  +PYPS+ +K  LA  T +++ QV+ WF NARRR+
Sbjct:  253 MKAWLFQHLTHPYPSEEQKRSLAQETGLTILQVNNWFINARRRI 296

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Nematostella
Match: EDO39375 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAC9])

HSP 1 Score: 49.6766 bits (117), Expect = 7.067e-7
Identity = 21/50 (42.00%), Postives = 35/50 (70.00%), Query Frame = 3

Query:  546 RENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRL 695
            ++ +S +K WL +H  +PYP++ EK  +A  T +++ QV+ WF NARRR+
Sbjct:  206 KQATSIMKTWLFQHIMHPYPTEDEKRSIAQQTNLTILQVNNWFINARRRI 255

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BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Medaka
Match: irx1a (iroquois-class homeodomain protein irx-1 [Source:NCBI gene;Acc:101162949])

HSP 1 Score: 119.783 bits (299), Expect = 6.765e-30
Identity = 60/116 (51.72%), Postives = 76/116 (65.52%), Query Frame = 3

Query:  402 IRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPD 749
            + SQ  L++    H A  A + +P      +             KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W +  K D  D
Sbjct:   81 MGSQYELKDSPGVHPAGFAAHTSPA----FYPYGQFQYGDPARPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGSRSKEDGED 192

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Medaka
Match: irx4b (iroquois-class homeodomain protein irx-4-like [Source:NCBI gene;Acc:101157469])

HSP 1 Score: 118.242 bits (295), Expect = 9.007e-30
Identity = 58/94 (61.70%), Postives = 73/94 (77.66%), Query Frame = 3

Query:  501 NHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWI--ANGKSDNPDSTSDSELSE 776
             H+ ++    +KNATRE +STLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W   A   SD+     DS+ +E
Sbjct:  106 GHSCLDSSSRRKNATRETTSTLKAWLQEHQKNPYPTKGEKIMLAIITRMTLTQVSTWFANARRRLKKENKVTWSPRACKSSDDRGYEDDSDEAE 199

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Medaka
Match: irx3a (iroquois homeobox 3 [Source:NCBI gene;Acc:101162111])

HSP 1 Score: 118.627 bits (296), Expect = 1.001e-29
Identity = 59/91 (64.84%), Postives = 72/91 (79.12%), Query Frame = 3

Query:  534 KNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDS--TSDSELSELFTREYEK 800
            KNATRE++STLKAWL EH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    ++D   +  TSD E  E   RE E+
Sbjct:  112 KNATRESTSTLKAWLSEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNRTDEEGNVYTSDHEGEEGDKREDEE 202

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Medaka
Match: irx4a (iroquois-class homeodomain protein irx-4-like [Source:NCBI gene;Acc:101159378])

HSP 1 Score: 117.472 bits (293), Expect = 4.051e-29
Identity = 56/97 (57.73%), Postives = 68/97 (70.10%), Query Frame = 3

Query:  477 TLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSE 767
            TL       +  ++    +KNATRE +STLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    K        D E
Sbjct:  127 TLGQYQYDRYGSMDGGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKGSEEKRYDDDE 223

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Medaka
Match: irx2a (iroquois homeobox 2 [Source:NCBI gene;Acc:101162396])

HSP 1 Score: 117.472 bits (293), Expect = 5.235e-29
Identity = 52/75 (69.33%), Postives = 64/75 (85.33%), Query Frame = 3

Query:  513 VNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKS 737
            +N    +KNATR+ ++TLKAWLQEH+ NPYP+KGEKI+LAI+T+M+LTQVSTWFANARRRLKKENK+ W    KS
Sbjct:  109 LNDPAYRKNATRDATATLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNKS 183

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Planmine SMEST
Match: SMESG000022899.1 (SMESG000022899.1)

HSP 1 Score: 545.814 bits (1405), Expect = 0.000e+0
Identity = 260/260 (100.00%), Postives = 260/260 (100.00%), Query Frame = 3

Query:  120 MEKPNCCLDPKMCLPFRLLDCVQTQATGYKYNVLFVKQNGNLMNCLKNHEEELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEPSDCSHEDPAT 899
            MEKPNCCLDPKMCLPFRLLDCVQTQATGYKYNVLFVKQNGNLMNCLKNHEEELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEPSDCSHEDPAT
Sbjct:    1 MEKPNCCLDPKMCLPFRLLDCVQTQATGYKYNVLFVKQNGNLMNCLKNHEEELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEPSDCSHEDPAT 260

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Planmine SMEST
Match: SMESG000022899.1 (SMESG000022899.1)

HSP 1 Score: 447.203 bits (1149), Expect = 3.197e-160
Identity = 214/214 (100.00%), Postives = 214/214 (100.00%), Query Frame = 3

Query:  258 KNHEEELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEPSDCSHEDPAT 899
            KNHEEELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEPSDCSHEDPAT
Sbjct:    7 KNHEEELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEPSDCSHEDPAT 220

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Planmine SMEST
Match: SMESG000022899.1 (SMESG000022899.1)

HSP 1 Score: 446.817 bits (1148), Expect = 3.771e-160
Identity = 214/214 (100.00%), Postives = 214/214 (100.00%), Query Frame = 3

Query:  258 KNHEEELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEPSDCSHEDPAT 899
            KNHEEELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEPSDCSHEDPAT
Sbjct:    4 KNHEEELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDVLENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEPSDCSHEDPAT 217

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Planmine SMEST
Match: SMESG000015279.1 (SMESG000015279.1)

HSP 1 Score: 131.724 bits (330), Expect = 1.134e-34
Identity = 80/179 (44.69%), Postives = 102/179 (56.98%), Query Frame = 3

Query:  414 DVLENWRQFHQAALANNLNPITLAHLHTINHA-DVNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGK--------------------------SDNPDSTSDSEL---SELFTREYEKPN-SNQKITKKNHIWSIIDM 857
            D  E WRQ HQA + NNL+P  LA   +  +  D      +KNATRE +S LKAWL +HK NPYP+KGEKI+LA++T+M+LTQVSTWFANARRRLKKENK+ W A  +                              DS  +SEL    E F  + EK + S  + +K N IWSI ++
Sbjct:  123 DHWETWRQIHQATINNNLSPHFLALCQSSGYPPDFPNAPRRKNATRETTSILKAWLNQHKKNPYPTKGEKIMLALITKMTLTQVSTWFANARRRLKKENKMTWTARTRHEDDIDETGDDDEDDDDEEDNENDDDISKSDSRFESELRKNDESFLSKSEKSDTSADETSKSNKIWSIAEI 301

[Close]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Planmine SMEST
Match: SMESG000026100.1 (SMESG000026100.1)

HSP 1 Score: 126.716 bits (317), Expect = 3.357e-33
Identity = 65/118 (55.08%), Postives = 85/118 (72.03%), Query Frame = 3

Query:  471 PITLAHLHTINHAD----VNQIQVKKNATRENSSTLKAWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGWIANGKS-DNPDSTSDSELSELFTREYEKPNS 809
            P++   LH  NH++    +N    +KNATRE +S LKAWL EHK NPYP+KGEKI+LA++T+M+LTQVSTWFANARRRLKKENK+ W  N KS D  D   D++ S++ +R  + P S
Sbjct:  108 PMSSRVLHVPNHSENFMEMNSHPRRKNATRETTSILKAWLNEHKKNPYPTKGEKIMLAVITKMTLTQVSTWFANARRRLKKENKMTWSPNQKSEDEADDLEDTDSSDIRSRLQDDPAS 225

The following BLAST results are available for this feature:

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Human
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Celegans
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Fly
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Zebrafish
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Xenopus
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Mouse
BLAST of Iroquois-class homeodomain protein IRX-6 vs. UniProt/SwissProt
BLAST of Iroquois-class homeodomain protein IRX-6 vs. TrEMBL
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Cavefish
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Sea Lamprey
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Yeast
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Nematostella
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Medaka
BLAST of Iroquois-class homeodomain protein IRX-6 vs. Planmine SMEST

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
IRX1	2.564e-29	48.00	iroquois homeobox 1 [Source:HGNC Symbol;Acc:HGNC:1...	[more]
IRX4	2.041e-28	80.95	iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6...	[more]
IRX4	2.041e-28	80.95	iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6...	[more]
IRX4	2.041e-28	80.95	iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6...	[more]
IRX4	2.313e-28	80.95	iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
irx-1	1.705e-23	55.95	Putative iroquois-class homeodomain protein irx-1 ...	[more]
ceh-60	1.395e-6	36.21	C. Elegans Homeobox [Source:UniProtKB/TrEMBL;Acc:...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mirr	2.427e-28	75.71	gene:FBgn0014343 transcript:FBtr0330077	[more]
mirr	2.482e-28	75.71	gene:FBgn0014343 transcript:FBtr0075911	[more]
mirr	2.482e-28	75.71	gene:FBgn0014343 transcript:FBtr0075912	[more]
caup	3.187e-28	79.37	gene:FBgn0015919 transcript:FBtr0075909	[more]
ara	7.681e-28	79.37	gene:FBgn0015904 transcript:FBtr0075908	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
irx3b	1.985e-30	52.85	iroquois homeobox 3b [Source:ZFIN;Acc:ZDB-GENE-030...	[more]
irx1a	6.702e-30	49.61	iroquois homeobox 1a [Source:ZFIN;Acc:ZDB-GENE-040...	[more]
irx1a	6.832e-30	51.64	iroquois homeobox 1a [Source:ZFIN;Acc:ZDB-GENE-040...	[more]
irx4b	1.028e-29	60.00	iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040...	[more]
irx4b	1.028e-29	60.00	iroquois homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-040...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
smc1b	9.110e-31	57.94	structural maintenance of chromosomes 1B [Source:X...	[more]
fancm	5.393e-29	69.33	FA complementation group M [Source:Xenbase;Acc:XB-...	[more]
lypla1	6.263e-29	68.42	lysophospholipase 1 [Source:Xenbase;Acc:XB-GENE-94...	[more]
fancm	9.542e-29	69.33	FA complementation group M [Source:Xenbase;Acc:XB-...	[more]
ndufaf5	1.507e-28	73.91	NADH:ubiquinone oxidoreductase complex assembly fa...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Irx1	1.444e-31	48.67	Iroquois homeobox 1 [Source:MGI Symbol;Acc:MGI:119...	[more]
Irx2	1.583e-30	68.00	Iroquois homeobox 2 [Source:MGI Symbol;Acc:MGI:119...	[more]
Irx1	2.993e-30	48.67	Iroquois homeobox 1 [Source:MGI Symbol;Acc:MGI:119...	[more]
Irx4	4.259e-29	72.22	Iroquois homeobox 4 [Source:MGI Symbol;Acc:MGI:135...	[more]
Irx4	4.259e-29	72.22	Iroquois homeobox 4 [Source:MGI Symbol;Acc:MGI:135...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q2TAQ8\|IRX1B_XENLA	1.150e-30	58.88	Iroquois-class homeodomain protein irx-1-B OS=Xeno...	[more]
sp\|Q6F2E3\|IRX1_XENTR	4.826e-30	57.94	Iroquois-class homeodomain protein irx-1 OS=Xenopu...	[more]
sp\|P81068\|IRX1_MOUSE	2.094e-29	48.67	Iroquois-class homeodomain protein IRX-1 OS=Mus mu...	[more]
sp\|Q9YGK8\|IRX1A_XENLA	2.398e-29	58.59	Iroquois-class homeodomain protein irx-1-A OS=Xeno...	[more]
sp\|P78414\|IRX1_HUMAN	1.231e-28	48.00	Iroquois-class homeodomain protein IRX-1 OS=Homo s...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1I8IV93	4.627e-33	57.14	Homeobox domain-containing protein OS=Macrostomum ...	[more]
A0A1I8J4E6	6.231e-32	60.91	Homeobox domain-containing protein OS=Macrostomum ...	[more]
A0A2H1CL68	2.363e-30	62.14	Homeobox domain protein OS=Fasciola hepatica OX=61...	[more]
A0A433TYJ0	2.426e-30	48.59	Homeobox domain-containing protein (Fragment) OS=E...	[more]
A0A1S8WJU4	2.960e-30	60.71	Homeobox domain protein OS=Opisthorchis viverrini ...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
irx1a	6.313e-30	53.10	iroquois homeobox 1 [Source:NCBI gene;Acc:10302468...	[more]
irx1a	6.744e-30	53.10	iroquois homeobox 1 [Source:NCBI gene;Acc:10302468...	[more]
irx4a	9.597e-30	56.25	iroquois-class homeodomain protein irx-4 [Source:N...	[more]
irx3b	1.600e-29	60.00	iroquois homeobox 3 [Source:NCBI gene;Acc:10303522...	[more]
irx2a	1.683e-29	69.33	iroquois homeobox 2 [Source:NCBI gene;Acc:10302499...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ENSPMAT00000002620.1	1.797e-31	52.00	pep scaffold:Pmarinus_7.0:GL484724:8057:10194:-1 g...	[more]
mkxb	1.368e-15	48.57	mohawk homeobox b [Source:ZFIN;Acc:ZDB-GENE-080513...	[more]
pknox2	1.497e-6	36.51	pbx/knotted 1 homeobox 2 [Source:ZFIN;Acc:ZDB-GENE...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
TOS8	1.002e-7	44.44	Homeodomain-containing protein and putative transc...	[more]
CUP9	3.815e-7	42.59	Homeodomain-containing transcriptional repressor; ...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4


Match Name	E-value	Identity	Description
EDO41982	2.194e-31	80.95	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41178	1.584e-8	41.82	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36439	6.029e-7	50.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39375	7.067e-7	42.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
irx1a	6.765e-30	51.72	iroquois-class homeodomain protein irx-1 [Source:N...	[more]
irx4b	9.007e-30	61.70	iroquois-class homeodomain protein irx-4-like [Sou...	[more]
irx3a	1.001e-29	64.84	iroquois homeobox 3 [Source:NCBI gene;Acc:10116211...	[more]
irx4a	4.051e-29	57.73	iroquois-class homeodomain protein irx-4-like [Sou...	[more]
irx2a	5.235e-29	69.33	iroquois homeobox 2 [Source:NCBI gene;Acc:10116239...	[more]

BLAST of Iroquois-class homeodomain protein IRX-6 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000022899.1	0.000e+0	100.00	SMESG000022899.1	[more]
SMESG000022899.1	3.197e-160	100.00	SMESG000022899.1	[more]
SMESG000022899.1	3.771e-160	100.00	SMESG000022899.1	[more]
SMESG000015279.1	1.134e-34	44.69	SMESG000015279.1	[more]
SMESG000026100.1	3.357e-33	55.08	SMESG000026100.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30007957 ID=SMED30007957|Name=Iroquois-class homeodomain protein IRX-6|organism=Schmidtea mediterranea sexual|type=transcript|length=1028bp
AATTTTTTTATTGATGACTTAAATAGACGGTAAAGGTGACAAAATGATCA
AATCACGAAAAATTTCAAGCTGAATTTTCATAAAACAATTTTTTGTTATT
TTAAAAAAAAAAAATTTCCATGGAAAAGCCAAATTGTTGTCTCGACCCGA
AAATGTGTTTGCCGTTCAGACTATTAGACTGTGTTCAGACCCAAGCTACC
GGATATAAATATAACGTTTTATTTGTAAAGCAGAATGGTAATTTAATGAA
CTGTTTAAAGAACCATGAAGAAGAATTACGAGATCGCAATTTGTTTTCCA
CGTACTACAACTGTTCCCGATATGGAGGAATTCCACCGGAACATATTATT
CTCGCCAATAAGGTGACAGGATTTTTAGCGATGAATGACCCAAACATGGA
TATTCGAAGCCAAGATGTCCTGGAAAATTGGAGACAGTTTCACCAAGCAG
CTTTAGCCAATAACCTCAACCCTATTACACTGGCCCATCTTCATACTATA
AATCATGCCGATGTCAATCAGATTCAAGTAAAAAAAAATGCCACCCGAGA
AAACTCCAGCACTCTCAAAGCCTGGCTACAAGAACACAAAGACAATCCTT
ATCCTTCGAAAGGTGAGAAAATTCTGCTCGCAATTCTCACACAAATGAGC
TTAACCCAAGTAAGTACTTGGTTTGCCAATGCTCGAAGACGATTGAAAAA
AGAAAACAAAATCGGTTGGATTGCAAATGGAAAATCAGACAATCCCGATT
CCACTTCAGATTCAGAATTATCAGAACTTTTTACTCGAGAATACGAGAAA
CCGAATTCCAATCAGAAAATTACCAAAAAAAATCACATTTGGTCTATTAT
TGACATGATTTCCGAACCGAGTGATTGCTCTCATGAAGACCCTGCAACTT
AAGGTCTTCGGTACTTAACTAATTAACTTCTGAACGTTTCAAATGGTATG
AAACTTTGCTTATCTGTAAATAATCACTAGACATGCATTTGTCATTATAA
ATACATTTTTTCCTGATTTAAAAAAAAA

protein sequence of SMED30007957-orf-1

>SMED30007957-orf-1 ID=SMED30007957-orf-1|Name=SMED30007957-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=261bp
MEKPNCCLDPKMCLPFRLLDCVQTQATGYKYNVLFVKQNGNLMNCLKNHE
EELRDRNLFSTYYNCSRYGGIPPEHIILANKVTGFLAMNDPNMDIRSQDV
LENWRQFHQAALANNLNPITLAHLHTINHADVNQIQVKKNATRENSSTLK
AWLQEHKDNPYPSKGEKILLAILTQMSLTQVSTWFANARRRLKKENKIGW
IANGKSDNPDSTSDSELSELFTREYEKPNSNQKITKKNHIWSIIDMISEP
SDCSHEDPAT*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000025	nervous system
PLANA:0000099	neuron
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR001356	Homeobox_dom
IPR008422	Homeobox_KN_domain
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated
GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organism development
GO:0007399	nervous system development
GO:0007507	heart development
GO:0030154	cell differentiation