ganglioside GM2 activator

Overview
Nameganglioside GM2 activator
Smed IDSMED30007906
Length (bp)635
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of ganglioside GM2 activator (SMED30007906) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for ganglioside GM2 activator (SMED30007906) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30007906

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
prepharyngeal regionSMED30007906h1SMcG0005862 SmedASXL_008154SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30007906h1SMcG0005862 SmedASXL_008154SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
gutSMED30007906h1SMcG0005862 dd_Smed_v4_214_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30007906h1SMcG0005862 dd_Smed_v6_214_1_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Human
Match: GM2A (GM2 ganglioside activator [Source:HGNC Symbol;Acc:HGNC:4367])

HSP 1 Score: 79.7221 bits (195), Expect = 5.592e-18
Identity = 46/169 (27.22%), Postives = 87/169 (51.48%), Query Frame = 1 
Query:   64 VGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIE 567
            + SF++  C    D G     +    + P+ + +   +  S  G     +  P+++ L L K+V G+ +KIPC   +GSCTFE+ C+ L+ LI  G  CP+ +   GL C CP ++   S    +  +P+++  +  ++++G Y +  +L  S++GK   C+ I   ++
Sbjct:   31 LSSFSWDNC----DEGKDPAVIRSLTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLE--LPSWLTTGNYRIESVL--SSSGKRLGCIKIAASLK 191
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Human
Match: GM2A (GM2 ganglioside activator [Source:HGNC Symbol;Acc:HGNC:4367])

HSP 1 Score: 65.4698 bits (158), Expect = 1.988e-13
Identity = 31/93 (33.33%), Postives = 52/93 (55.91%), Query Frame = 1 
Query:  136 FNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKM 411
              + P+ + +   +  S  G     +  P+++ L L K+V G+ +KIPC   +GSCTFE+ C+ L+ LI  G  CP+ +   GL C CP +++
Sbjct:   10 LTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEV 102
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Human
Match: GM2A (GM2 ganglioside activator [Source:HGNC Symbol;Acc:HGNC:4367])

HSP 1 Score: 55.4546 bits (132), Expect = 2.232e-9
Identity = 31/103 (30.10%), Postives = 53/103 (51.46%), Query Frame = 1 
Query:   64 VGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEI 369
            + SF++  C    D G     +    + P+ + +   +  S  G     +  P+++ L L K+V G+ +KIPC   +GSCTFE+ C+ L+ LI  G  CP+ +
Sbjct:   46 LSSFSWDNC----DEGKDPAVIRSLTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPL 144
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Zebrafish
Match: gm2a (GM2 ganglioside activator [Source:ZFIN;Acc:ZDB-GENE-050417-373])

HSP 1 Score: 76.6406 bits (187), Expect = 4.932e-17
Identity = 44/160 (27.50%), Postives = 83/160 (51.88%), Query Frame = 1 
Query:  100 KDCGSK--TIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 570
            ++CG       +   ++ P+ + +   +    KG    ++  P+ + + + ++V G+ VKIPC+  +GSC + N C+ L  LI    +CP+ +   GL C CP +  D +    +I IP+V+  +  ++++G Y V  IL   +TGK   CL I+  + +
Sbjct:   42 QNCGKPDDPANLKSLDISPDPIPIPGRLTADAKGTTSVELASPLSVNVTVEREVAGMWVKIPCLDEIGSCHYPNVCDLLNQLIPPPQDCPEPLHTYGLPCHCPFKAGDYALPSSEIDIPDVE--LPGWLTNGHYRVEGIL--GSTGKELGCLKISFSLHS 197
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Zebrafish
Match: gm2a (GM2 ganglioside activator [Source:ZFIN;Acc:ZDB-GENE-050417-373])

HSP 1 Score: 76.6406 bits (187), Expect = 4.932e-17
Identity = 44/160 (27.50%), Postives = 83/160 (51.88%), Query Frame = 1 
Query:  100 KDCGSK--TIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 570
            ++CG       +   ++ P+ + +   +    KG    ++  P+ + + + ++V G+ VKIPC+  +GSC + N C+ L  LI    +CP+ +   GL C CP +  D +    +I IP+V+  +  ++++G Y V  IL   +TGK   CL I+  + +
Sbjct:   42 QNCGKPDDPANLKSLDISPDPIPIPGRLTADAKGTTSVELASPLSVNVTVEREVAGMWVKIPCLDEIGSCHYPNVCDLLNQLIPPPQDCPEPLHTYGLPCHCPFKAGDYALPSSEIDIPDVE--LPGWLTNGHYRVEGIL--GSTGKELGCLKISFSLHS 197
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Zebrafish
Match: GM2A (ganglioside GM2 activator-like [Source:NCBI gene;Acc:100534777])

HSP 1 Score: 65.855 bits (159), Expect = 7.478e-13
Identity = 41/144 (28.47%), Postives = 72/144 (50.00%), Query Frame = 1 
Query:   70 SFTFSEC--IILKDCGSKTIKVDY--FNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEEL-ENLIMGNECPKEILELGLKCECPLRKMDISF--KDHKIYIP--EVKGTIAKF 474
            +FTF++      + CG+      +   ++YPN +     +  +    +  D+  P+ + L L K+V G  VKIPC++ +GSC + + C++L E + M + CP+ +      C CP +  D ++   D  IYIP   +  TI  F
Sbjct:   37 TFTFTKFNRFSWEKCGNPDAPFHWKTLHVYPNAIPSPGIVLGTASASIAVDLTSPLPVNLTLEKEVAGAWVKIPCVNGVGSCYYPDACDQLAEVMSMFSLCPEHLRLNRSSCRCPFKAGDYNWPTSDSGIYIPNFSLSDTITNF 180
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Xenopus
Match: cdx2 (caudal type homeobox 2 [Source:Xenbase;Acc:XB-GENE-483306])

HSP 1 Score: 79.7221 bits (195), Expect = 6.659e-18
Identity = 49/170 (28.82%), Postives = 88/170 (51.76%), Query Frame = 1 
Query:   55 LLIVGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNT----GKVHLCLD 549
             L V  F++S C    D  S   K+   ++ P+ + +  ++  ST       +  PV++ +   K++LG  +K+PCI N+GSCT++N CE ++ +   G +CP+ +   GL C CP ++   S  D  + +P+V   +  ++++G Y V+ +L   N     GK    LD
Sbjct:   34 FLSVNGFSWSNC----DGESLPGKIKSLSVSPDPINIPGDLTVSTVLETKVPLTSPVKVIITAEKELLGEWMKVPCIDNVGSCTYDNVCELIDTIFPPGQQCPEPLRTYGLPCHCPFKEGVYSLPDTTLTLPDVD--LPAWLANGNYRVTGVLIADNKEIGCGKFTFSLD 197
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Xenopus
Match: cdx2 (caudal type homeobox 2 [Source:Xenbase;Acc:XB-GENE-483306])

HSP 1 Score: 79.7221 bits (195), Expect = 6.659e-18
Identity = 49/170 (28.82%), Postives = 88/170 (51.76%), Query Frame = 1 
Query:   55 LLIVGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNT----GKVHLCLD 549
             L V  F++S C    D  S   K+   ++ P+ + +  ++  ST       +  PV++ +   K++LG  +K+PCI N+GSCT++N CE ++ +   G +CP+ +   GL C CP ++   S  D  + +P+V   +  ++++G Y V+ +L   N     GK    LD
Sbjct:   34 FLSVNGFSWSNC----DGESLPGKIKSLSVSPDPINIPGDLTVSTVLETKVPLTSPVKVIITAEKELLGEWMKVPCIDNVGSCTYDNVCELIDTIFPPGQQCPEPLRTYGLPCHCPFKEGVYSLPDTTLTLPDVD--LPAWLANGNYRVTGVLIADNKEIGCGKFTFSLD 197
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Xenopus
Match: ENSXETT00000034714.1 (ganglioside GM2 activator-like [Source:NCBI gene;Acc:108644461])

HSP 1 Score: 72.4034 bits (176), Expect = 3.249e-15
Identity = 43/157 (27.39%), Postives = 79/157 (50.32%), Query Frame = 1 
Query:   55 LLIVGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELE-NLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSN 522
             L V  FT+S C      G+ +  +   ++ PN + +  E+  S      + +  P ++ L   KK+L   + +PCI N+GSCT++N CE L+ +  +G  CP+ +   G+ C CP   +  S  +    +P V+  +  +++SG Y V+ ++   N
Sbjct:   33 FLSVNDFTWSNCD-----GNWSGNIISLSVSPNPINIPGELTISIVLETTERLTAPTKIILTAKKKILLSWITLPCIDNIGSCTYDNICEVLDTSFPLGEPCPEPLHTYGIPCHCPFEGV-YSLPEATFTLPNVE--LPSWLTSGDYHVNAVIMADN 181
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Xenopus
Match: ENSXETT00000021057.1 (ganglioside GM2 activator-like [Source:NCBI gene;Acc:108644461])

HSP 1 Score: 66.2402 bits (160), Expect = 5.869e-13
Identity = 40/155 (25.81%), Postives = 78/155 (50.32%), Query Frame = 1 
Query:   64 VGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVR-LKLGLWKKVLGISVKIPCISNLGSCTFENGCEELE-NLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSN 522
            V  FT+S C      G+ +  +   ++ PN + +  E+  S      + +  P + + L +  ++L   + +PCI N+GSCT++N CE L+ +  +G  CP+ +   G+ C CP   +  S  +    +P V+  +  +++SG Y V+ ++   N
Sbjct:   33 VNDFTWSNCD-----GNWSGNIISLSVSPNPINIPGELTISIVLETTERLTAPTKVMLLKIRTRILLSWITLPCIDNIGSCTYDNICEVLDTSFPLGEPCPEPLHTYGIPCHCPFEGV-YSLPEATFTLPNVE--LPSWLTSGDYHVNAVIMADN 179
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Xenopus
Match: ENSXETT00000034666.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:3:11083466:11086128:1 gene:ENSXETG00000011805.1 transcript:ENSXETT00000034666.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.8322 bits (120), Expect = 1.762e-7
Identity = 37/163 (22.70%), Postives = 77/163 (47.24%), Query Frame = 1 
Query:   16 YLNIIEMFLVVLSLLIVGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLIM-GNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVS 501
            +L + E +  ++   ++ +F++S C   ++     +K   FN  PN +     + +S        +  P+++   + +++LG  + +PC  N GSCT +N C  L+ +   G  CP  +    + C CP +    +F    I++P +K  +  ++ SG Y  +
Sbjct:   11 HLALNEPYGQIVDTAMLSNFSWSNC---EENLPGRVKHLIFN--PNVISFPGILNFSESYETNVPLISPLKIVYNVEREILGDWINVPCFENFGSCTLDNLCNLLDLIFKPGEACPALLSTYNIPCHCPFKAGTYTFPKISIHLPNLK--VPTWLVSGKYHTT 166
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Mouse
Match: Gm2a (GM2 ganglioside activator protein [Source:MGI Symbol;Acc:MGI:95762])

HSP 1 Score: 82.0333 bits (201), Expect = 5.310e-19
Identity = 49/183 (26.78%), Postives = 92/183 (50.27%), Query Frame = 1 
Query:   22 NIIEMFLVVLSLLIVGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIE 567
            ++    LV   L  +G F++  C    D G     +    + P+ + +  ++  S +G+    +  P +++L + K+V G  VKIPC+  LGSC++EN C+ ++  I  G  CP+ +   GL C CP ++   S       +P+++  +  ++S+G Y +  IL  S+ GK   C+ I   ++
Sbjct:   17 SVAPARLVPKRLSQLGGFSWDNC----DEGKDPAVIKSLTIQPDPIVVPGDVVVSLEGKTSVPLTAPQKVELTVEKEVAGFWVKIPCVEQLGSCSYENICDLIDEYIPPGESCPEPLHTYGLPCHCPFKEGTYSLPTSNFTVPDLE--LPSWLSTGNYRIQSIL--SSGGKRLGCIKIAASLK 191
[Close]
BLAST of ganglioside GM2 activator vs. UniProt/SwissProt
Match: sp|Q8HXX6|SAP3_MACFA (Ganglioside GM2 activator OS=Macaca fascicularis OX=9541 GN=GM2A PE=2 SV=2)

HSP 1 Score: 82.4185 bits (202), Expect = 2.340e-18
Identity = 49/169 (28.99%), Postives = 87/169 (51.48%), Query Frame = 1 
Query:   64 VGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIE 567
            +GSF++  C    D G     +    + P+ + +   +  S  G     +  P++++L L K+V G+ +KIPC   +GSCTFE+ C+ L+ LI  G  CP+ +   GL C CP ++   S    +  +P ++  +  ++++G Y +  IL  SN GK   C+ I   ++
Sbjct:   28 LGSFSWDNC----DEGKDPAVIRSLTLEPDPILIPGNVTVSVVGSTSVLLSSPLKVELVLEKEVAGLWIKIPCTDYIGSCTFEDFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPHLE--LPSWLTTGNYRIESIL--SNRGKRLGCIKIAASLK 188
[Close]
BLAST of ganglioside GM2 activator vs. UniProt/SwissProt
Match: sp|Q60648|SAP3_MOUSE (Ganglioside GM2 activator OS=Mus musculus OX=10090 GN=Gm2a PE=1 SV=2)

HSP 1 Score: 82.0333 bits (201), Expect = 3.714e-18
Identity = 49/183 (26.78%), Postives = 92/183 (50.27%), Query Frame = 1 
Query:   22 NIIEMFLVVLSLLIVGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIE 567
            ++    LV   L  +G F++  C    D G     +    + P+ + +  ++  S +G+    +  P +++L + K+V G  VKIPC+  LGSC++EN C+ ++  I  G  CP+ +   GL C CP ++   S       +P+++  +  ++S+G Y +  IL  S+ GK   C+ I   ++
Sbjct:   17 SVAPARLVPKRLSQLGGFSWDNC----DEGKDPAVIKSLTIQPDPIVVPGDVVVSLEGKTSVPLTAPQKVELTVEKEVAGFWVKIPCVEQLGSCSYENICDLIDEYIPPGESCPEPLHTYGLPCHCPFKEGTYSLPTSNFTVPDLE--LPSWLSTGNYRIQSIL--SSGGKRLGCIKIAASLK 191
[Close]
BLAST of ganglioside GM2 activator vs. UniProt/SwissProt
Match: sp|P17900|SAP3_HUMAN (Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4)

HSP 1 Score: 79.7221 bits (195), Expect = 2.686e-17
Identity = 46/169 (27.22%), Postives = 87/169 (51.48%), Query Frame = 1 
Query:   64 VGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIE 567
            + SF++  C    D G     +    + P+ + +   +  S  G     +  P+++ L L K+V G+ +KIPC   +GSCTFE+ C+ L+ LI  G  CP+ +   GL C CP ++   S    +  +P+++  +  ++++G Y +  +L  S++GK   C+ I   ++
Sbjct:   31 LSSFSWDNC----DEGKDPAVIRSLTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLE--LPSWLTTGNYRIESVL--SSSGKRLGCIKIAASLK 191
[Close]
BLAST of ganglioside GM2 activator vs. TrEMBL
Match: F2U603 (ML domain-containing protein OS=Salpingoeca rosetta (strain ATCC 50818 / BSB-021) OX=946362 GN=PTSG_03577 PE=4 SV=1)

HSP 1 Score: 95.9005 bits (237), Expect = 7.059e-21
Identity = 50/175 (28.57%), Postives = 95/175 (54.29%), Query Frame = 1 
Query:   58 LIVGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI----MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 570
            + + SF+FS+C       S    V   ++ P+ +K+   I +S  G +   ++ P++ ++ L KKV G+ +KIPC+ ++GSC++++ C+ L  LI     GN CP  +  +G+ C CPL   + +     +  P +  ++  ++S+G Y  ++  + +N G V  C +I L +ET
Sbjct:   44 ITLKSFSFSDCAP----SSAPAHVSKLSISPDPIKLPGNITFSAAGSLSATVDAPIKAEVKLEKKV-GVWIKIPCVDDIGSCSYDDLCKVLAKLIPVDPHGN-CPAPLPSMGIPCRCPLTSFNFNVPTTTVSAPALPPSVPSWLSNGDYKATLEAK-TNAGDVLFCANIELSLET 211
[Close]
BLAST of ganglioside GM2 activator vs. TrEMBL
Match: A0A4W3JVK4 (ML domain-containing protein OS=Callorhinchus milii OX=7868 PE=4 SV=1)

HSP 1 Score: 90.5077 bits (223), Expect = 3.347e-19
Identity = 48/167 (28.74%), Postives = 88/167 (52.69%), Query Frame = 1 
Query:   70 SFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIE 567
            +F+++ C       ++ + +   ++ P+ + +   ++ S    V   ++ P+ + L L K+V GI V IPCI  LGSCT+EN C++L+ LI  G  CP+ +   G+ C CP +K D +  D   YIP +   +  +++SG Y  + IL         + + I+L+ +
Sbjct:    6 AFSWANCR-----NAEPVVIKSLSIKPDPVSIPGFLRASVFASVGVSLQAPLTIHLTLEKEVAGIWVTIPCIEELGSCTYENICQQLDALIPPGQNCPEPLFTYGIPCHCPFKKGDYNLPDSSFYIPSLD--LPSWLTSGNYKATAILSGEKGSLACVKISISLRAD 165
[Close]
BLAST of ganglioside GM2 activator vs. TrEMBL
Match: A0A1S3GK74 (ganglioside GM2 activator OS=Dipodomys ordii OX=10020 GN=Gm2a PE=4 SV=1)

HSP 1 Score: 90.8929 bits (224), Expect = 4.201e-19
Identity = 51/169 (30.18%), Postives = 88/169 (52.07%), Query Frame = 1 
Query:   64 VGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIE 567
            +GSF++  C    D G     +    + P+ + +   +  S +G+    +  P +++L + K+V G  VKIPC+  LGSCT+EN CE L+N I  G  CP+ +   GL C CP ++   S       +P+++  +  ++S+G Y V  IL  S+ G+   C+ I + + 
Sbjct:   36 LGSFSWDNC----DEGKDPAVIQSLTLEPDPIVVPGNVTVSVQGKTQVPLSSPQKVELTVEKEVAGFWVKIPCVEQLGSCTYENVCEMLDNYIPPGQTCPEPLYTYGLPCHCPFKEGTYSLPSSDFTLPDLE--LPSWLSTGNYRVQSIL--SSGGERLACIKIAVSLR 196
[Close]
BLAST of ganglioside GM2 activator vs. TrEMBL
Match: K4FYQ1 (Ganglioside GM2 activator OS=Callorhinchus milii OX=7868 PE=2 SV=1)

HSP 1 Score: 90.5077 bits (223), Expect = 7.076e-19
Identity = 48/167 (28.74%), Postives = 88/167 (52.69%), Query Frame = 1 
Query:   70 SFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIE 567
            +F+++ C       ++ + +   ++ P+ + +   ++ S    V   ++ P+ + L L K+V GI V IPCI  LGSCT+EN C++L+ LI  G  CP+ +   G+ C CP +K D +  D   YIP +   +  +++SG Y  + IL         + + I+L+ +
Sbjct:   34 AFSWANCR-----NAEPVVIKSLSIKPDPVSIPGFLRASVFASVGVSLQAPLTIHLTLEKEVAGIWVTIPCIEELGSCTYENICQQLDALIPPGQNCPEPLFTYGIPCHCPFKKGDYNLPDSSFYIPSLD--LPSWLTSGNYKATAILSGEKGSLACVKISISLRAD 193
[Close]
BLAST of ganglioside GM2 activator vs. TrEMBL
Match: A0A5J5MY36 (ML domain-containing protein OS=Muntiacus reevesi OX=9886 GN=FD755_000181 PE=4 SV=1)

HSP 1 Score: 89.3521 bits (220), Expect = 8.832e-19
Identity = 48/168 (28.57%), Postives = 90/168 (53.57%), Query Frame = 1 
Query:   67 GSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLIMGNE-CPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIE 567
            GSF++  C    D G     ++   + P+ + +   +  + + +    +  P++++L + K + G  VKIPC+ N+GSCT++N C  LE LI   E CP+ +   GL C CP ++   S       +P+++  +  ++S+G Y +  IL  SN+GK   C++I+  ++
Sbjct:    5 GSFSWDNC----DAGKDPAVINSLTLEPDPIAIPGNLTITAEAKTSAVLSDPLKVELTVEKHIAGFWVKIPCVDNVGSCTYDNFCNVLEMLIPIEEPCPEPLHTYGLPCHCPFKQGAYSLPKSDFMLPDLE--LPSWLSTGNYRLQTIL--SNSGKRLACVNISASLK 164
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Cavefish
Match: gm2a (GM2 ganglioside activator [Source:NCBI gene;Acc:103029073])

HSP 1 Score: 78.5666 bits (192), Expect = 9.173e-18
Identity = 42/146 (28.77%), Postives = 75/146 (51.37%), Query Frame = 1 
Query:  136 FNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 570
             ++ P+ + +  ++  S  G     +  P+ + + L K+V G  VKIPC+  +GSC + + C+ L  LI  G +CP+ +   GL C CP +  D +      Y+P +   +  ++++G Y V  +L   N GK   CL ++L I +
Sbjct:   56 LSLSPDPITIPGDLTASASGSTSVALVSPLSVNVTLDKEVAGFWVKIPCVEEIGSCHYTDACDILNQLIPPGQDCPEPLHTYGLPCHCPFKAGDYTLPQSDFYLPNLD--LPFWLTNGNYRVQGVL--GNMGKELGCLKVSLTIHS 197
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Sea Lamprey
Match: gm2a (GM2 ganglioside activator [Source:ZFIN;Acc:ZDB-GENE-050417-373])

HSP 1 Score: 75.0998 bits (183), Expect = 3.601e-17
Identity = 45/180 (25.00%), Postives = 88/180 (48.89%), Query Frame = 1 
Query:   34 MFLVVLSLLIVGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 570
            +FL+    L V SF ++ C    D       +    + P+ + +  ++  +  G     + GP+   + L K++ G+ +++PC+  +GSC +++ C+ L  L   G +CP+ +   GL C CP +K   +F +    IP V+  +  ++++G Y   + L  S  GK   CL ++L +  
Sbjct:   16 VFLISSKHLKVKSFVWNNCGPESD----VAILKSLQISPDPVVIPGDLTVALNGVTTVTLAGPIEANVTLDKELAGLWIEVPCLDQIGSCVYKDVCQLLNQLTPPGQDCPEPLFSYGLPCNCPFKKGQYNFPESDFTIPYVE--LPSWLTNGNYRSKVTL--SMGGKEVACLKLSLSLHA 187
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Nematostella
Match: EDO43020 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZX0])

HSP 1 Score: 57.7658 bits (138), Expect = 2.981e-11
Identity = 28/109 (25.69%), Postives = 56/109 (51.38%), Query Frame = 1 
Query:  118 TIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYI 444
            TI ++   + P+ + M   +  S    V + +    +L+L + K++    + IPC+++ GSCT++N C  L   +M ++C K + + G+ C+CP+     S     + I
Sbjct:    9 TIVINSLELAPDPVSMPGTVNVSLSLTVKRHLPSSTKLRLDVQKQIGSAWIPIPCVASYGSCTYDNFCNLLRG-VMFSKCNKTMEDTGIPCDCPIPTGTFSVPTQSLVI 116
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Nematostella
Match: EDO36431 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIM3])

HSP 1 Score: 54.6842 bits (130), Expect = 4.581e-9
Identity = 36/157 (22.93%), Postives = 74/157 (47.13%), Query Frame = 1 
Query:  112 SKTIKVDYFNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGI-SVKIPCISNLGSCTFENGCEELENLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPE---VKGTIAKFISSGTYDVSIILEDSNTGKVHL-CLDINLKIE 567
            S TI ++   + P+ L +   +  S    + + +     L+L + KKV G+  ++IPCI  +GSC + N CE + +    ++C + +   G+ C+CP+     +     I +P        +  ++ +G Y V     D  +   HL C+++  +++
Sbjct:  142 SDTIAINSMQLTPSPLALPGTVNVSATLTIKRHLPSYTTLRLNIQKKVFGLFWLRIPCIKGMGSCDYSNFCEMIRSAAF-SKCDEVMEAQGVPCDCPIPTGQFALPLQSIPVPADMLSAIPVPDWVVNGKYWVRAEFLDPFSR--HLGCIEVQAEVD 295
[Close]
BLAST of ganglioside GM2 activator vs. Ensembl Medaka
Match: gm2a (GM2 ganglioside activator [Source:NCBI gene;Acc:101172744])

HSP 1 Score: 80.8777 bits (198), Expect = 1.019e-18
Identity = 42/146 (28.77%), Postives = 77/146 (52.74%), Query Frame = 1 
Query:  136 FNMYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLI-MGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 570
              + P+ + +  E+  +  G    +++ P+ L + L K+V GI VK+PC+ +LGSC + + C+ L+ LI  G +CP+ +   GL C CP +    S      Y+P V   +  ++++G Y V  +L     G+   CL++ L + +
Sbjct:   54 LTVSPDPIAIPGELTAAASGSTSVELDAPLSLNVTLKKEVAGIWVKVPCLDDLGSCHYPDACDLLDQLIPPGQDCPEPLHTYGLPCHCPFKAGLYSLPQSDFYLPNVD--LPYWLTNGKYRVQGVL--GVPGQELGCLEVALSVHS 195
[Close]
BLAST of ganglioside GM2 activator vs. Planmine SMEST
Match: SMESG000000730.1 (SMESG000000730.1)

HSP 1 Score: 285.804 bits (730), Expect = 9.949e-100
Identity = 142/143 (99.30%), Postives = 142/143 (99.30%), Query Frame = 1 
Query:  142 MYPNNLKMGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 570
            MYPNNLKMGSEIQYSTKG VLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET
Sbjct:    1 MYPNNLKMGSEIQYSTKGSVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 143
[Close]
BLAST of ganglioside GM2 activator vs. Planmine SMEST
Match: SMESG000000730.1 (SMESG000000730.1)

HSP 1 Score: 270.011 bits (689), Expect = 1.061e-93
Identity = 135/136 (99.26%), Postives = 135/136 (99.26%), Query Frame = 1 
Query:  163 MGSEIQYSTKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 570
            MGSEIQYSTKG VLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET
Sbjct:    1 MGSEIQYSTKGSVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELENLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISSGTYDVSIILEDSNTGKVHLCLDINLKIET 136
The following BLAST results are available for this feature:
BLAST of ganglioside GM2 activator vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
GM2A5.592e-1827.22GM2 ganglioside activator [Source:HGNC Symbol;Acc:... [more]
GM2A1.988e-1333.33GM2 ganglioside activator [Source:HGNC Symbol;Acc:... [more]
GM2A2.232e-930.10GM2 ganglioside activator [Source:HGNC Symbol;Acc:... [more]
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BLAST of ganglioside GM2 activator vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of ganglioside GM2 activator vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of ganglioside GM2 activator vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
gm2a4.932e-1727.50GM2 ganglioside activator [Source:ZFIN;Acc:ZDB-GEN... [more]
gm2a4.932e-1727.50GM2 ganglioside activator [Source:ZFIN;Acc:ZDB-GEN... [more]
GM2A7.478e-1328.47ganglioside GM2 activator-like [Source:NCBI gene;A... [more]
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BLAST of ganglioside GM2 activator vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cdx26.659e-1828.82caudal type homeobox 2 [Source:Xenbase;Acc:XB-GENE... [more]
cdx26.659e-1828.82caudal type homeobox 2 [Source:Xenbase;Acc:XB-GENE... [more]
ENSXETT00000034714.13.249e-1527.39ganglioside GM2 activator-like [Source:NCBI gene;A... [more]
ENSXETT00000021057.15.869e-1325.81ganglioside GM2 activator-like [Source:NCBI gene;A... [more]
ENSXETT00000034666.11.762e-722.70pep primary_assembly:Xenopus_tropicalis_v9.1:3:110... [more]
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BLAST of ganglioside GM2 activator vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Gm2a5.310e-1926.78GM2 ganglioside activator protein [Source:MGI Symb... [more]
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BLAST of ganglioside GM2 activator vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q8HXX6|SAP3_MACFA2.340e-1828.99Ganglioside GM2 activator OS=Macaca fascicularis O... [more]
sp|Q60648|SAP3_MOUSE3.714e-1826.78Ganglioside GM2 activator OS=Mus musculus OX=10090... [more]
sp|P17900|SAP3_HUMAN2.686e-1727.22Ganglioside GM2 activator OS=Homo sapiens OX=9606 ... [more]
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BLAST of ganglioside GM2 activator vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
F2U6037.059e-2128.57ML domain-containing protein OS=Salpingoeca rosett... [more]
A0A4W3JVK43.347e-1928.74ML domain-containing protein OS=Callorhinchus mili... [more]
A0A1S3GK744.201e-1930.18ganglioside GM2 activator OS=Dipodomys ordii OX=10... [more]
K4FYQ17.076e-1928.74Ganglioside GM2 activator OS=Callorhinchus milii O... [more]
A0A5J5MY368.832e-1928.57ML domain-containing protein OS=Muntiacus reevesi ... [more]
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BLAST of ganglioside GM2 activator vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
gm2a9.173e-1828.77GM2 ganglioside activator [Source:NCBI gene;Acc:10... [more]
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BLAST of ganglioside GM2 activator vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
gm2a3.601e-1725.00GM2 ganglioside activator [Source:ZFIN;Acc:ZDB-GEN... [more]
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BLAST of ganglioside GM2 activator vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of ganglioside GM2 activator vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO430202.981e-1125.69Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO364314.581e-922.93Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of ganglioside GM2 activator vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
gm2a1.019e-1828.77GM2 ganglioside activator [Source:NCBI gene;Acc:10... [more]
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BLAST of ganglioside GM2 activator vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000000730.19.949e-10099.30SMESG000000730.1[more]
SMESG000000730.11.061e-9399.26SMESG000000730.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30007906 ID=SMED30007906|Name=ganglioside GM2 activator|organism=Schmidtea mediterranea sexual|type=transcript|length=635bp
GATCATTAACTAGCATACTTAAATATTATAGAAATGTTTTTGGTGGTACT
CTCATTATTAATTGTTGGTTCATTCACATTTTCTGAATGTATAATACTGA
AAGATTGTGGAAGCAAGACAATTAAAGTGGATTACTTTAATATGTACCCC
AATAACTTGAAAATGGGCTCTGAAATACAATATTCAACCAAGGGCAGAGT
CTTGCAAGATATTGAAGGTCCCGTCAGATTAAAGCTCGGTTTATGGAAAA
AAGTACTAGGAATAAGTGTCAAGATACCATGCATAAGTAATTTAGGTTCA
TGCACATTTGAAAACGGATGTGAAGAACTTGAAAACCTGATTATGGGTAA
CGAATGTCCGAAAGAAATTCTAGAACTTGGCCTTAAATGTGAGTGCCCTT
TGAGAAAGATGGACATTTCCTTCAAGGATCACAAAATATATATCCCAGAA
GTCAAAGGTACCATTGCAAAATTCATATCCAGTGGTACTTATGACGTGTC
TATTATTCTTGAAGATTCGAATACTGGAAAAGTTCATTTGTGTTTAGATA
TTAACTTAAAGATAGAAACTTAAAGACATCGACACTGTTTAATGTGACTT
ATTTTCAAGGCTTTTCATCAATTTTGTCATTAATT
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protein sequence of SMED30007906-orf-1

>SMED30007906-orf-1 ID=SMED30007906-orf-1|Name=SMED30007906-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=180bp
MFLVVLSLLIVGSFTFSECIILKDCGSKTIKVDYFNMYPNNLKMGSEIQY
STKGRVLQDIEGPVRLKLGLWKKVLGISVKIPCISNLGSCTFENGCEELE
NLIMGNECPKEILELGLKCECPLRKMDISFKDHKIYIPEVKGTIAKFISS
GTYDVSIILEDSNTGKVHLCLDINLKIET*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0004563beta-N-acetylhexosaminidase activity
GO:0008047enzyme activator activity
GO:0016787hydrolase activity
Vocabulary: biological process
TermDefinition
GO:0007611learning or memory
GO:0009313oligosaccharide catabolic process
GO:0019915lipid storage
GO:0050877neurological system process
GO:0050885neuromuscular process controlling balance
GO:0006629lipid metabolic process
GO:0006665sphingolipid metabolic process
GO:0006689ganglioside catabolic process
GO:0043085positive regulation of catalytic activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
PLANA:0000420parapharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR036846GM2-AP_sf
IPR028996GM2-AP
IPR003172ML_dom
Vocabulary: cellular component
TermDefinition
GO:0005764lysosome
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR036846GM2-AP, lipid-recognition domain superfamilyGENE3DG3DSA:2.70.220.10coord: 12..179
e-value: 1.7E-36
score: 127.7
IPR036846GM2-AP, lipid-recognition domain superfamilySUPERFAMILYSSF63707Ganglioside M2 (gm2) activatorcoord: 21..177
IPR003172MD-2-related lipid-recognition domainPFAMPF02221E1_DerP2_DerF2coord: 22..177
e-value: 1.5E-12
score: 48.1
IPR028996Ganglioside GM2 activatorPANTHERPTHR17357GM2 GANGLIOSIDE ACTIVATOR PROTEINcoord: 22..178
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..17
score: 0.788