Otoferlin

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKT-KPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVS-----------GNENL--------------------------------GKSDFNVPSYNLTKLERHEGHIRLPSDTSSVE-SDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPK---HIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH----LPKKEENFESQY------------------VHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            M+L++ L++++ ++   +   KV FR   F +   +  +   +    F WP+A  +D+ + L I+    ++   +KL G   +VL  ++ +  + + +T +D+   I   +L  E+ Y +              G+E+L                                G+S F+  +  L K   H+   + P + + +E  D D+      D +D       S  +L      K  K    ++P + +  D+Q+S+T+ EAR L G N++P+  V  G  K+ T +K  TN P+YNEYF FDF +S   + ++II+I  +  K+ + +     G ++G F +D  TVYS   H F +KWA+L DP   +SG KG+VK D++V+  GD  K P+K ++ ++ +IE N+L+P+ +   +R      V +Y+AE LP MNT +M+N+K+A +G+ K L DPYV+V FAG  G T V   SY P WN+Q++FT+ FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLL+ +      TS P+ +    V V    P+S + AGK E + LF +  EA++I +  G   KP+TFE++IG  G   D  S      P+KE   E +                     S T P      D  YFH+PY  +KPC+Y+ +   D R RL+  NI+D +  +L E +  +  +  + +K    R ++  +E       + LS     +G + +T LD +  K     LE M     +    +   T+   ++   +F++ L     +PQH +PD+F++M+ +N RVAY R+ ++DL+ S +  E G+ C  V T++LK      LP K       + +QA++++YLWLGL K  + +  GLP GF      +       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DN+        ++  PP +V+EI+D DS    +F+GR F +P V +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  K           +L  +   V D  +G      + +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNFN  +    + LP N    PP++I  ++   FG   +VG+H ++ L  +
Sbjct:    1 MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFS--AMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRS-----GTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGV-PPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDK---GFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGD--KPITFEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMI-KTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLK------LPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK----------ADLPPINGPV-DVDRG----PIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF 1229          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDI-VPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDA--CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            I+ +K+Y  ELE+  ++  F+    +F+L RGK  +++DG   ++R  G FKG++C+Y V       +D+  E   +S    F                         +DP  ++ +VRVYVV+  +LHPADINGKADPYI +R+G  +IRD+ENYI K LNP+FG+ F++E +FP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY+ HGY  W+D   P+ IL  LC+   +  P +      V++  + F   S IED++G +  + E +AL+ L +WEDI    C+LV EH+ETRPL   +KPGIEQG LE+WVDMFP     P  P+DISPRKP  YELR++I  T+ V L D +FFT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWR++F FDYL AE+ IV  K ++++  DE EYK P  L +Q+ D+D   +D  +G ++  L++FP+ AK  K C     +        ++FK K+V+GWWPL+         E +  E+ G VE E+ L+  EEAE NP GL R EP PLEKPNRPD SF+ FLNP  + +YF+
Sbjct: 1405 IDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVP----LPEDVSREAGYDSTYGMF--------------------QGIPSNDP--INVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLL------ARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFL 1958          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKT-KPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVS-----------GNENL--------------------------------GKSDFNVPSYNLTKLERHEGHIRLPSDTSSVE-SDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPK---HIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH----LPKKEENFESQY------------------VHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            M+L++ L++++ ++   +   KV FR   F +   +  +   +    F WP+A  +D+ + L I+    ++   +KL G   +VL  ++ +  + + +T +D+   I   +L  E+ Y +              G+E+L                                G+S F+  +  L K   H+   + P + + +E  D D+      D +D       S  +L      K  K    ++P + +  D+Q+S+T+ EAR L G N++P+  V  G  K+ T +K  TN P+YNEYF FDF +S   + ++II+I  +  K+ + +     G ++G F +D  TVYS   H F +KWA+L DP   +SG KG+VK D++V+  GD  K P+K ++ ++ +IE N+L+P+ +   +R      V +Y+AE LP MNT +M+N+K+A +G+ K L DPYV+V FAG  G T V   SY P WN+Q++FT+ FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLL+ +      TS P+ +    V V    P+S + AGK E + LF +  EA++I +  G   KP+TFE++IG  G   D  S      P+KE   E +                     S T P      D  YFH+PY  +KPC+Y+ +   D R RL+  NI+D +  +L E +  +  +  + +K    R ++  +E       + LS     +G + +T LD +  K     LE M     +    +   T+   ++   +F++ L     +PQH +PD+F++M+ +N RVAY R+ ++DL+ S +  E G+ C  V T++LK      LP K       + +QA++++YLWLGL K  + +  GLP GF      +       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DN+        ++  PP +V+EI+D DS    +F+GR F +P V +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  K           +L  +   V D  +G      + +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNFN  +    + LP N    PP++I  ++   FG   +VG+H ++ L  +
Sbjct:    1 MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFS--AMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRS-----GTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGV-PPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDK---GFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGD--KPITFEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMI-KTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLK------LPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK----------ADLPPINGPV-DVDRG----PIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF 1229          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDI-VPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDA--CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYR 5985
            I+ +K+Y  ELE+  ++  F+    +F+L RGK  +++DG   ++R  G FKG++C+Y V       +D+  E   +S    F                         +DP  ++ +VRVYVV+  +LHPADINGKADPYI +R+G  +IRD+ENYI K LNP+FG+ F++E +FP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY+ HGY  W+D   P+ IL  LC+   +  P +      V++  + F   S IED++G +  + E +AL+ L +WEDI    C+LV EH+ETRPL   +KPGIEQG LE+WVDMFP     P  P+DISPRKP  YELR++I  T+ V L D +FFT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWR++F FDYL AE+ IV  K ++++  DE EYK P  L +Q+ D+D   +D  +G ++  L++FP+ AK  K C     +        ++FK K+V+GWWPL+         E +  E+ G VE E+ L+  EEAE NP GL R EP PLEKPNRPD +F+ FLNP  +IKY I  R
Sbjct: 1405 IDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVP----LPEDVSREAGYDSTYGMF--------------------QGIPSNDP--INVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLL------ARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTR 1961          

Query:  511 SDTSSVESDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKV-IGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT-------------------------------------------TSQPDSIKIG---VDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKK------EENF-------ESQYVHSLTEPKYAYTF---------DNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKM-KMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFT----SKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLE--NLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLD--HESDHLQ-------SLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVT--------------NPVPGEPEK-----------------LIRFVPKEEMESA-DWWTRYYATLGDLDDPNLYKPEDEILVESESEDEIRRDI 4005
             DT +++ +  + +  P  D+   D   +   S  P+R  KL   I    ++ +++QI++TI EAR L G+NI+P+  +  G +K+ + +K  TN+PFYNEYF FDF   ++ L ++II+I         V  H   G V IG F +D  TVY+   H F  KWA+L DP    +G KG++K D+SV+  GD  K   KT   E+P IE N+LIP      +R      V +Y+AE LP MN+ IM+N+ +A +GD K L DP+VEVSFAG  G T V      P W++Q+IF E FPP   R++I V D   + D  ++T FIDL KI N  + ++ GFLPT+GP+WINLYG+PR +S   ++   Q  N+   EGV+FRGR+L+ I                                              SQ  S K     V+V S +     V  K E +LLF + FEAT+I ++IG K  P++FE+SIG  G   D  SH   K      EE+        +    H +  P  + T          +  Y ++P+ +KKPC+Y I+   D   RL   N+L+K+   L E + +V  L    ++    + +K  +  F       +S  +       +T LD K   L    LE M K +  +  +     ++D  I +  +FV+ +   + +PQH +PDVF++M+ +N RVAY RI ++DL++S +  + G+ CG + T +LK        +   +++QA++ +YLWLG +K        LP G+  +  +    +  PP  + Y E+  FQLR ++Y  R LI +D +GLSDPF KV    H + + +  +T SP W++ ++ +++V + + K +   PP VV+E++D D+    E++G     P V +   +Y   +L +  ++ G +  GD+L  F+L+++ P      + G P +E  ++ ++                  +P ++RP +  +R+E+L WGVR++++++++S                V++P+ +IE GG  +KS +I+ +  +PNF+    +  + LP N    PP+SI  +++  FG   +VG + I  L ++    K+ E L    + D  Q       SLTA     A+S      A     +  P  T     + A+P +                PV  EP K                   R +  E  E+  DWW++YYA+L          P+ +        DE+  DI
Sbjct:   29 GDTEALQEEPSHQEG-PRGDLVHDDASIFPVPSASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKIS--------VFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEP-IEKNLLIPNGF-PLERPWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDK-GFLPTFGPAWINLYGSPRNHS---LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFFEATMIDRKIGDK--PISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADFLEESIEEVRELIKISQEAPEEK-MKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPG----KRPAGWSVQAKVDVYLWLGSIKHASAILDNLPVGYEAEMSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSG----LQGLPPVEPPDITQIYP----------------VPANIRPVLSKYRVEVLFWGVREMKKVQLLS----------------VDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLC--KLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDI 1250          

Query: 4234 IKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMI-EDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDS-IVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCD--PFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIV 6087
            ++IY  +LE+  ++  F+   ++F L+RGK  E+D G +  DR  G FKG+ CIY   +D+  E        D  +L                      ++ + +   H V  ++RVY+V   NL PAD +GK+DPYI++++G  EI+DR+ YIPK LNP+FGR FE++ TFP+ES L + +YD D +  DDLIGET IDLENR+ S HR  CGL S Y   GY  W+D+  PT IL  LC+ N +  P +      ++I  + F+  ++  E+D    ++S E LAL VLH+WEDI PE  C+LV EHIETRPLY ++KPG+EQG L+MWVDMFP     P PP+DISPR+P  YELR+ I  TE+V L D N FT +KS DIY+K W+K  + D Q+TD H+ SL+G+G FNWRF+F F YL AE   ++ K +NI+ +++ E KTP  L +QV D + L SD  +G L+  L+ FP+ AK  K+CD   F+++    K ++F+ K+VRGWWP                E+ G VE E  LV  EEAE NP G  R+EP PL KPNRPD SF  F++P+  + Y I    K  +I   I++I ++ +VLFIY  PG  SR IV
Sbjct: 1277 LQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLD-GDRVIGKFKGSFCIYKSPQDSSSE--------DSGQL----------------------RIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP--GKIQIGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDI-PEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPF-----------SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDI-VPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDA--CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYR 5985
            I+ +K+Y  ELE+  ++  F+    +F+L RGK  +++DG   ++R  G FKG++C+Y V       +D+  E   +S    F                         +DP  ++ +VRVYVV+  +LHPADINGKADPYI +R+G  +IRD+ENYI K LNP+FG+ F++E +FP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY+ HGY  W+D   P+ IL  LC+   +  P +      V++  + F   S IED++G +  + E +AL+ L +WEDI    C+LV EH+ETRPL   +KPGIEQG LE+WVDMFP     P  P+DISPRKP  YELR++I  T+ V L D +FFT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWR++F FDYL AE+ IV  K ++++  DE EYK P  L +Q+ D+D   +D  +G ++  L++FP+ AK  K C     +        ++FK K+V+GWWPL+         E +  E+ G VE E+ L+  EEAE NP GL R EP PLEKPNRPD +F+ FLNP  +IKY I  R
Sbjct:  638 IDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVP----LPEDVSREAGYDSTYGMF--------------------QGIPSNDP--INVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLAR------NENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTR 1194          

Query: 2152 RYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            R ++  +E       + LS     +G + +T LD +  K     LE M     +    +   T+   ++   +F++ L     +PQH +PD+F++M+ +N RVAY R+ ++DL+ S +  E G+ C  V T++LK      LP K       + +QA++++YLWLGL K  + +  GLP GF      +       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DN+        ++  PP +V+EI+D DS    +F+GR F +P V +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  K           +L  +   V D  +G      + +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNFN  +    + LP N    PP++I  ++   FG   +VG+H ++ L  +
Sbjct:   11 RRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLK------LPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK----------ADLPPINGPV-DVDRG----PIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF 482          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDI-VPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDA--CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            I+ +K+Y  ELE+  ++  F+    +F+L RGK  +++DG   ++R  G FKG++C+Y V       +D+  E   +S    F                         +DP  ++ +VRVYVV+  +LHPADINGKADPYI +R+G  +IRD+ENYI K LNP+FG+ F++E +FP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY+ HGY  W+D   P+ IL  LC+   +  P +      V++  + F   S IED++G +  + E +AL+ L +WEDI    C+LV EH+ETRPL   +KPGIEQG LE+WVDMFP     P  P+DISPRKP  YELR++I  T+ V L D +FFT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWR++F FDYL AE+ IV  K ++++  DE EYK P  L +Q+ D+D   +D  +G ++  L++FP+ AK  K C     +        ++FK K+V+GWWPL+         E +  E+ G VE E+ L+  EEAE NP GL R EP PLEKPNRPD SF+ FLNP  + +YF+
Sbjct:  638 IDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVP----LPEDVSREAGYDSTYGMF--------------------QGIPSNDP--INVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLL------ARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFL 1191          

Query: 2152 RYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            R ++  +E       + LS     +G + +T LD +  K     LE M     +    +   T+   ++   +F++ L     +PQH +PD+F++M+ +N RVAY R+ ++DL+ S +  E G+ C  V T++LK      LP K       + +QA++++YLWLGL K  + +  GLP GF      +       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DN+        ++  PP +V+EI+D DS    +F+GR F +P V +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  K           +L  +   V D  +G      + +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNFN  +    + LP N    PP++I  ++   FG   +VG+H ++ L  +
Sbjct:   11 RRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLK------LPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK----------ADLPPINGPV-DVDRG----PIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF 482          

Query: 5059 GSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFP-SGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKF------PKPAKYYKS---------------------CDPFQHSDACA-------------------------KFNLFKNKKVRGWWPLV---YNPKXXXXXXXNGLEIG-------GTVEMEMDLVLGEEAESNPAGLGREEPLP---LEKPNRPDGSFLNFLNPW------NTIKYFIKY 5982
            GSQ   L+ +AL +L        +  LV EH+E+RPL+  +    ++G L M+VD+FP    AIP P +I+PRKP +Y+LRI ++          +F   E   D+Y+KA++        KTDTHFR L G G FNWRF+  FDY   E  +V   KN +     E      L +++ D +    D ++G ++  L  F      P     Y +                     C  F     C                            N+F+++ + GWWP++   Y  ++    ++   ++G       G VEM+M L+  +EA+  PAG  R EP     LEKP+R      ++ N W        IKYF  Y
Sbjct: 1635 GSQ---LQTIALFILR-------QMNLVPEHVESRPLFSDKGGRTQKGELRMFVDIFPMEYGAIPAPFNIAPRKPINYQLRIAVMDVRGAIPVKRSF--AEPVSDLYVKAFINGM-TKGHKTDTHFRVLDGTGEFNWRFLLNFDYNPWEKKVVAYTKNRFFCKPVEELVDPILVIELWDKNKFRKDRLLGDIELDLLDFIEGIGSPSDVGVYSTKKRQRGVKCPKCCTRRGCLCKCCIFCFETKCLCGKRKVKKKPFPKPVLFVEPEGYDDTVNIFESRNLYGWWPMLTEEYPHEEPQNAKKKNDDVGKDPKWIMGLVEMDMLLLTKQEADQEPAGKKRSEPNHSPFLEKPDRK-----SWANSWLVSRIKPCIKYFWHY 1996          

Query: 4564 VDFI------VRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYD 4989
            VDF+      VRVY+++   L      G+ D Y+ +  G + +  ++NY  +  +PIFG   +M VT P E  L + V    R+  D  IG TTIDLENR L+  R T GL   +   G ++W+D   P  ILKS C K  +  PK +
Sbjct: 1375 VDFVGPTRCLVRVYIIEANGLISNARKGRVDSYVKLHCGKQNVNLKKNYRSECCDPIFGERVDMTVTIPLEKDLKITVMGKRRILSDQEIGSTTIDLENRLLTKWRATGGLSGQFTVQGELQWRDQMTPMEILKSYCYKMMLSVPKIE 1522          

Query: 2731 MEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNV-YRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLI---SVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY--YVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDL 3927
            M+   +QLR Y+  G +L+    +  S  FV++   ++ +++ +   +++PIW+ET++  +++     + +   PP V +E+    S+ +E  +G    +P+V I G+       QW+ + +      G +L  F+L   +              ++L+ +  +   N K     E+  IP + RP    F ++ L WGVR L        K+H ++ ++R        P + + IG        ++D    PNF + +I    VI  LP   +  PP+ IN  +   F  + +VG+ +++DL +Y  ++  K+      +SDH +    Q D+      V  + FD             ++    P +T                + M   DWW+RYYA++   
Sbjct:  967 MQTGKWQLRCYIMWGNDLLPVVKNS-SRAFVRISFAQYSKQTLLVDNSQNPIWNETVMFKSVLIAGGTRDIMKYPPVVSVEVVGECSNNEEANLGHFETKPNV-ICGNTDVRGTPQWFPLKFSNGRTRGAVLACFELYSEED-------------KDLIPLEPKCKHNYK-----ERSEIPTEFRPQFDKFHVQFLCWGVRNL--------KKHKLLAVRR--------PFVGLTIGDQEFTLQPLKDVRRDPNFPEPMIVFGEVI--LPSALELSPPLIINLFDARAFNRQPLVGSCLVSDLHKYVSHIVPKV------KSDHAERW-EQLDL------VITEEFDQI-----------IRMVRVPTLTT---------------DPMVPLDWWSRYYASMSQF 1294          

Query:  931 IGEFSIDAKTVYSNESHSFFYKWAVL----IDPKAP---TSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWN-------QQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVDVRSCNPV--SNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRG------KKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTA-KKTLLDVKYQKLIRM--GLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQ--AQLQIYLWLGLLKDMRLYK 2661
            +GEFS     V  +   S   KW  L    +D + P        G++KV LSV    + P      D +E           QI          + + V+  E L     + M N ++      K     YV V    +   T + S     D N       Q+I    ++P  +S +  ++ D        I    + +  I       E G+LPT+GP+++N++   R   ++   +  +G  Q+   G  F GRL IAI      +     +     +P+  + ++    E Y  F S+    +I  +      P+   +SIG+ G   +E+            +  +S T P        +YF +P+ + +P   + AP E    R+ + N+L K+   L   + +V  + ++         ++A+  +++ ++    S  K L  I      A  + +LD + +K++++    EK   S   +   +    + M +K  +  ++  +    D Q  +P V + M+     + + +I   ++  S    + G+ CG    + ++   +  L  + N   +  A L   +W G    +  +K
Sbjct:  175 VGEFSCYLSEVIHSPDRSVIAKWVALGFPGMDDEEPDDIAYENCGFLKVTLSVYRIDESPPTLIDDDGKE-----------QIWSGAHLIDYTLKIRVFSVEQL----IRQMINERKI-----KKKQRFYVMVQCGAHKTETTMESAFLDEDANIASVKFEQEIYLPIQWPTVISEIIFSLFDKKGRGKTCIGKATLPMKMIYEPG---ETGYLPTFGPAFLNVFDCERVTRFSIFSRKMRGSQQD---GSRFVGRLFIAIDCVEYMEKANAQIMHLDHSPIMEAESICKNLEWYNCFCSMSGLNMINPQFAS--DPVCIMMSIGSFGSTSNEF------------RSCNSSTLPAEPNWDGCKYFTMPWGNLRPVAEVNAPWEVIEHRIEMSNVLMKMTNMLDTMIWEVRRIGNKAIDHVSSVGMEALECLEQQID----SASKYLGRINPVSSNALDRHILDYRKEKILKLREHFEKEAFSIDYSDGEVDAKLLRMLLKIRSMTLELAE----DVQMTIPPVLIKMMSHGKLIGFAKIPISEIFQSDDEAQSGEWCGRTRAINIQ---WPTLVDQRNRKREHVAVLHAKMWFGRTDQLTKWK 727          

Query: 5059 GSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFP-SGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKF------PKPAKYYKS---------------------CDPFQHSDACA-------------------------KFNLFKNKKVRGWWPLV---YNPKXXXXXXXNGLEIG-------GTVEMEMDLVLGEEAESNPAGLGREEPLP---LEKPNRPDGSFLNFLNPW------NTIKYFIKY 5982
            GSQ   L+ +AL +L        +  LV EH+E+RPL+  +    ++G L M+VD+FP    AIP P +I+PRKP +Y+LRI ++          +F   E   D+Y+KA++        KTDTHFR L G G FNWRF+  FDY   E  +V   KN +     E      L +++ D +    D ++G ++  L  F      P     Y +                     C  F     C                            N+F+++ + GWWP++   Y  ++    ++   ++G       G VEM+M L+  +EA+  PAG  R EP     LEKP+R      ++ N W        IKYF  Y
Sbjct: 1508 GSQ---LQTIALFILR-------QMNLVPEHVESRPLFSDKGGRTQKGELRMFVDIFPMEYGAIPAPFNIAPRKPINYQLRIAVMDVRGAIPVKRSF--AEPVSDLYVKAFINGM-TKGHKTDTHFRVLDGTGEFNWRFLLNFDYNPWEKKVVAYTKNRFFCKPVEELVDPILVIELWDKNKFRKDRLLGDIELDLLDFIEGIGSPSDVGVYSTKKRQRGVKCPKCCTRRGCLCKCCIFCFETKCLCGKRKVKKKPFPKPVLFVEPEGYDDTVNIFESRNLYGWWPMLTEEYPHEEPQNAKKKNDDVGKDPKWIMGLVEMDMLLLTKQEADQEPAGKKRSEPNHSPFLEKPDRK-----SWANSWLVSRIKPCIKYFWHY 1869          

Query: 4564 VDFI------VRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYD 4989
            VDF+      VRVY+++   L      G+ D Y+ +  G + +  ++NY  +  +PIFG   +M VT P E  L + V    R+  D  IG TTIDLENR L+  R T GL   +   G ++W+D   P  ILKS C K  +  PK +
Sbjct: 1248 VDFVGPTRCLVRVYIIEANGLISNARKGRVDSYVKLHCGKQNVNLKKNYRSECCDPIFGERVDMTVTIPLEKDLKITVMGKRRILSDQEIGSTTIDLENRLLTKWRATGGLSGQFTVQGELQWRDQMTPMEILKSYCYKMMLSVPKIE 1395          

Query: 2731 MEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNV-YRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLI---SVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY--YVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDL 3927
            M+   +QLR Y+  G +L+    +  S  FV++   ++ +++ +   +++PIW+ET++  +++     + +   PP V +E+    S+ +E  +G    +P+V I G+       QW+ + +      G +L  F+L   +              ++L+ +  +   N K     E+  IP + RP    F ++ L WGVR L        K+H ++ ++R        P + + IG        ++D    PNF + +I    VI  LP   +  PP+ IN  +   F  + +VG+ +++DL +Y  ++  K+      +SDH +    Q D+      V  + FD             ++    P +T                + M   DWW+RYYA++   
Sbjct:  840 MQTGKWQLRCYIMWGNDLLPVVKNS-SRAFVRISFAQYSKQTLLVDNSQNPIWNETVMFKSVLIAGGTRDIMKYPPVVSVEVVGECSNNEEANLGHFETKPNV-ICGNTDVRGTPQWFPLKFSNGRTRGAVLACFELYSEED-------------KDLIPLEPKCKHNYK-----ERSEIPTEFRPQFDKFHVQFLCWGVRNL--------KKHKLLAVRR--------PFVGLTIGDQEFTLQPLKDVRRDPNFPEPMIVFGEVI--LPSALELSPPLIINLFDARAFNRQPLVGSCLVSDLHKYVSHIVPKV------KSDHAERW-EQLDL------VITEEFDQI-----------IRMVRVPTLTT---------------DPMVPLDWWSRYYASMSQF 1167          

Query:  931 IGEFSIDAKTVYSNESHSFFYKWAVL----IDPKAP---TSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWN-------QQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVDVRSCNPV--SNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRG------KKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTA-KKTLLDVKYQKLIRM--GLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQ--AQLQIYLWLGLLKDMRLYK 2661
            +GEFS     V  +   S   KW  L    +D + P        G++KV LSV    + P      D +E           QI          + + V+  E L     + M N ++      K     YV V    +   T + S     D N       Q+I    ++P  +S +  ++ D        I    + +  I       E G+LPT+GP+++N++   R   ++   +  +G  Q+   G  F GRL IAI      +     +     +P+  + ++    E Y  F S+    +I  +      P+   +SIG+ G   +E+            +  +S T P        +YF +P+ + +P   + AP E    R+ + N+L K+   L   + +V  + ++         ++A+  +++ ++    S  K L  I      A  + +LD + +K++++    EK   S   +   +    + M +K  +  ++  +    D Q  +P V + M+     + + +I   ++  S    + G+ CG    + ++   +  L  + N   +  A L   +W G    +  +K
Sbjct:   48 VGEFSCYLSEVIHSPDRSVIAKWVALGFPGMDDEEPDDIAYENCGFLKVTLSVYRIDESPPTLIDDDGKE-----------QIWSGAHLIDYTLKIRVFSVEQL----IRQMINERKI-----KKKQRFYVMVQCGAHKTETTMESAFLDEDANIASVKFEQEIYLPIQWPTVISEIIFSLFDKKGRGKTCIGKATLPMKMIYEPG---ETGYLPTFGPAFLNVFDCERVTRFSIFSRKMRGSQQD---GSRFVGRLFIAIDCVEYMEKANAQIMHLDHSPIMEAESICKNLEWYNCFCSMSGLNMINPQFAS--DPVCIMMSIGSFGSTSNEF------------RSCNSSTLPAEPNWDGCKYFTMPWGNLRPVAEVNAPWEVIEHRIEMSNVLMKMTNMLDTMIWEVRRIGNKAIDHVSSVGMEALECLEQQID----SASKYLGRINPVSSNALDRHILDYRKEKILKLREHFEKEAFSIDYSDGEVDAKLLRMLLKIRSMTLELAE----DVQMTIPPVLIKMMSHGKLIGFAKIPISEIFQSDDEAQSGEWCGRTRAINIQ---WPTLVDQRNRKREHVAVLHAKMWFGRTDQLTKWK 600          

Query: 5059 GSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFP-SGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKF------PKPAKYYKS---------------------CDPFQHSDACA-------------------------KFNLFKNKKVRGWWPLV---YNPKXXXXXXXNGLEIG-------GTVEMEMDLVLGEEAESNPAGLGREEPLP---LEKPNRPDGSFLNFLNPW------NTIKYFIKY 5982
            GSQ   L+ +AL +L        +  LV EH+E+RPL+  +    ++G L M+VD+FP    AIP P +I+PRKP +Y+LRI ++          +F   E   D+Y+KA++        KTDTHFR L G G FNWRF+  FDY   E  +V   KN +     E      L +++ D +    D ++G ++  L  F      P     Y +                     C  F     C                            N+F+++ + GWWP++   Y  ++    ++   ++G       G VEM+M L+  +EA+  PAG  R EP     LEKP+R      ++ N W        IKYF  Y
Sbjct: 1508 GSQ---LQTIALFILR-------QMNLVPEHVESRPLFSDKGGRTQKGELRMFVDIFPMEYGAIPAPFNIAPRKPINYQLRIAVMDVRGAIPVKRSF--AEPVSDLYVKAFINGM-TKGHKTDTHFRVLDGTGEFNWRFLLNFDYNPWEKKVVAYTKNRFFCKPVEELVDPILVIELWDKNKFRKDRLLGDIELDLLDFIEGIGSPSDVGVYSTKKRQRGVKCPKCCTRRGCLCKCCIFCFETKCLCGKRKVKKKPFPKPVLFVEPEGYDDTVNIFESRNLYGWWPMLTEEYPHEEPQNAKKKNDDVGKDPKWIMGLVEMDMLLLTKQEADQEPAGKKRSEPNHSPFLEKPDRK-----SWANSWLVSRIKPCIKYFWHY 1869          

Query: 4564 VDFI------VRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYD 4989
            VDF+      VRVY+++   L      G+ D Y+ +  G + +  ++NY  +  +PIFG   +M VT P E  L + V    R+  D  IG TTIDLENR L+  R T GL   +   G ++W+D   P  ILKS C K  +  PK +
Sbjct: 1248 VDFVGPTRCLVRVYIIEANGLISNARKGRVDSYVKLHCGKQNVNLKKNYRSECCDPIFGERVDMTVTIPLEKDLKITVMGKRRILSDQEIGSTTIDLENRLLTKWRATGGLSGQFTVQGELQWRDQMTPMEILKSYCYKMMLSVPKIE 1395          

Query: 2731 MEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNV-YRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLI---SVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY--YVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDL 3927
            M+   +QLR Y+  G +L+    +  S  FV++   ++ +++ +   +++PIW+ET++  +++     + +   PP V +E+    S+ +E  +G    +P+V I G+       QW+ + +      G +L  F+L   +              ++L+ +  +   N K     E+  IP + RP    F ++ L WGVR L        K+H ++ ++R        P + + IG        ++D    PNF + +I    VI  LP   +  PP+ IN  +   F  + +VG+ +++DL +Y  ++  K+      +SDH +    Q D+      V  + FD             ++    P +T                + M   DWW+RYYA++   
Sbjct:  840 MQTGKWQLRCYIMWGNDLLPVVKNS-SRAFVRISFAQYSKQTLLVDNSQNPIWNETVMFKSVLIAGGTRDIMKYPPVVSVEVVGECSNNEEANLGHFETKPNV-ICGNTDVRGTPQWFPLKFSNGRTRGAVLACFELYSEED-------------KDLIPLEPKCKHNYK-----ERSEIPTEFRPQFDKFHVQFLCWGVRNL--------KKHKLLAVRR--------PFVGLTIGDQEFTLQPLKDVRRDPNFPEPMIVFGEVI--LPSALELSPPLIINLFDARAFNRQPLVGSCLVSDLHKYVSHIVPKV------KSDHAERW-EQLDL------VITEEFDQI-----------IRMVRVPTLTT---------------DPMVPLDWWSRYYASMSQF 1167          

Query:  931 IGEFSIDAKTVYSNESHSFFYKWAVL----IDPKAP---TSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWN-------QQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVDVRSCNPV--SNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRG------KKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTA-KKTLLDVKYQKLIRM--GLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQ--AQLQIYLWLGLLKDMRLYK 2661
            +GEFS     V  +   S   KW  L    +D + P        G++KV LSV    + P      D +E           QI          + + V+  E L     + M N ++      K     YV V    +   T + S     D N       Q+I    ++P  +S +  ++ D        I    + +  I       E G+LPT+GP+++N++   R   ++   +  +G  Q+   G  F GRL IAI      +     +     +P+  + ++    E Y  F S+    +I  +      P+   +SIG+ G   +E+            +  +S T P        +YF +P+ + +P   + AP E    R+ + N+L K+   L   + +V  + ++         ++A+  +++ ++    S  K L  I      A  + +LD + +K++++    EK   S   +   +    + M +K  +  ++  +    D Q  +P V + M+     + + +I   ++  S    + G+ CG    + ++   +  L  + N   +  A L   +W G    +  +K
Sbjct:   48 VGEFSCYLSEVIHSPDRSVIAKWVALGFPGMDDEEPDDIAYENCGFLKVTLSVYRIDESPPTLIDDDGKE-----------QIWSGAHLIDYTLKIRVFSVEQL----IRQMINERKI-----KKKQRFYVMVQCGAHKTETTMESAFLDEDANIASVKFEQEIYLPIQWPTVISEIIFSLFDKKGRGKTCIGKATLPMKMIYEPG---ETGYLPTFGPAFLNVFDCERVTRFSIFSRKMRGSQQD---GSRFVGRLFIAIDCVEYMEKANAQIMHLDHSPIMEAESICKNLEWYNCFCSMSGLNMINPQFAS--DPVCIMMSIGSFGSTSNEF------------RSCNSSTLPAEPNWDGCKYFTMPWGNLRPVAEVNAPWEVIEHRIEMSNVLMKMTNMLDTMIWEVRRIGNKAIDHVSSVGMEALECLEQQID----SASKYLGRINPVSSNALDRHILDYRKEKILKLREHFEKEAFSIDYSDGEVDAKLLRMLLKIRSMTLELAE----DVQMTIPPVLIKMMSHGKLIGFAKIPISEIFQSDDEAQSGEWCGRTRAINIQ---WPTLVDQRNRKREHVAVLHAKMWFGRTDQLTKWK 600          

Query: 4582 VYVVKGINLHPADINGKADPYILVR--IGNKEIRDRENYIPKT-LNPIFGRCFEMEVTFPQ--ESFLLVQVYDWDRLTKDDLIG 4818
            + V K  NL P DI G +DPY+ +      K  + +++   +  LNP+F      ++   Q  E+ +L+QV DWDR+ KDDL+G
Sbjct:  286 INVSKAYNLRPMDITGASDPYVKIEQTFNGKRFKSKKSSTKRANLNPVFHETLVFDIPSSQIAETNILIQVMDWDRIGKDDLLG 369          

Query: 4582 VYVVKGINLHPADINGKADPYILVR--IGNKEIRDRENYIPKT-LNPIFGRCFEMEVTFPQ--ESFLLVQVYDWDRLTKDDLIG 4818
            + V K  NL P DI G +DPY+ +      K  + +++   +  LNP+F      ++   Q  E+ +L+QV DWDR+ KDDL+G
Sbjct:  221 INVSKAYNLRPMDITGASDPYVKIEQTFNGKRFKSKKSSTKRANLNPVFHETLVFDIPSSQIAETNILIQVMDWDRIGKDDLLG 304          

Query: 4561 SVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +V  +VRVYVV+G+ + P D+ G +D Y+ + +G K   DR ++ P   NP+FGR FEME T P +  L V VYD D++ KD++IG+T IDLE+RW + HR T GL + Y   GY  W D +LP+ IL  LC+K  I  P Y    + +E+ G  F  +++I  D+  Q    E L+L VL N  D +P    KLV EH+ETR L   + P +EQG L++W+++F +   +P PIDI+P  PA +E+R+V+     ++  D N F K  S D+Y+  W +  D   Q TD H+RS +G   FNWR VF   Y   ED +V + K    ++E E+K P  + +QV D D+L  D  +  L+  LS    P    + C P+       + NLFK K + GW+PL  N      +        G +++ +++    EA + PAG G++ P+ LE P RPD SF    +P  + ++ +
Sbjct:  152 TVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKI-KDEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYY--YGNVIEVDGMLFGDETLISKDEELQ----ERLSLAVLKNM-DKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPSPIDITPVPPADFEVRVVVKNLVGIQAGDKNIFGKLMS-DVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMVIRRKAGL-LEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR--KRINLFKRKVINGWFPLQSN--AHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPPYRPDSSFNPLTHPCKSFQHIL 610          

Query: 4561 SVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPEC--KLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +V  +VRVYVV+G+ + P D+ G +D Y+ + +G K   DR ++ P   NP+FGR FEME T P +  L V VYD D++ KD++IG+T IDLE+RW + HR T GL + Y   GY  W D +LP+ IL  LC+K  I  P Y    + +E+ G  F  +++I  D+  Q    E L+L VL N  D +P    KLV EH+ETR L   + P +EQG L++W+++F +   +P PIDI+P  PA +E+R+V+     ++  D N F K  S D+Y+  W +  D   Q TD H+RS +G   FNWR VF   Y   ED +V + K    ++E E+K P  + +QV D D+L  D  +  L+  LS    P    + C P+       + NLFK K + GW+PL  N      +        G +++ +++    EA + PAG G++ P+ LE P RPD SF    +P  + ++ +
Sbjct:  855 TVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKI-KDEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYY--YGNVIEVDGMLFGDETLISKDEELQ----ERLSLAVLKNM-DKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPSPIDITPVPPADFEVRVVVKNLVGIQAGDKNIFGKLMS-DVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMVIRRKAGL-LEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR--KRINLFKRKVINGWFPLQSN--AHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPPYRPDSSFNPLTHPCKSFQHIL 1313          

Query: 4561 SVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPEC--KLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +V  +VRVYVV+G+ + P D+ G +D Y+ + +G K   DR ++ P   NP+FGR FEME T P +  L V VYD D++ KD++IG+T IDLE+RW + HR T GL + Y   GY  W D +LP+ IL  LC+K  I  P Y    + +E+ G  F  +++I  D+  Q    E L+L VL N  D +P    KLV EH+ETR L   + P +EQG L++W+++F +   +P PIDI+P  PA +E+R+V+     ++  D N F K  S D+Y+  W +  D   Q TD H+RS +G   FNWR VF   Y   ED +V + K    ++E E+K P  + +QV D D+L  D  +  L+  LS    P    + C P+       + NLFK K + GW+PL  N      +        G +++ +++    EA + PAG G++ P+ LE P RPD SF    +P  + ++ +
Sbjct:  943 TVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKI-KDEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYY--YGNVIEVDGMLFGDETLISKDEELQ----ERLSLAVLKNM-DKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPSPIDITPVPPADFEVRVVVKNLVGIQAGDKNIFGKLMS-DVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMVIRRKAGL-LEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR--KRINLFKRKVINGWFPLQSN--AHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPPYRPDSSFNPLTHPCKSFQHIL 1401          

Query: 4561 SVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPEC--KLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +V  +VRVYVV+G+ + P D+ G +D Y+ + +G K   DR ++ P   NP+FGR FEME T P +  L V VYD D++ KD++IG+T IDLE+RW + HR T GL + Y   GY  W D +LP+ IL  LC+K  I  P Y    + +E+ G  F  +++I  D+  Q    E L+L VL N  D +P    KLV EH+ETR L   + P +EQG L++W+++F +   +P PIDI+P  PA +E+R+V+     ++  D N F K  S D+Y+  W +  D   Q TD H+RS +G   FNWR VF   Y   ED +V + K    ++E E+K P  + +QV D D+L  D  +  L+  LS    P    + C P+       + NLFK K + GW+PL  N      +        G +++ +++    EA + PAG G++ P+ LE P RPD SF    +P  + ++ +
Sbjct: 1151 TVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKI-KDEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYY--YGNVIEVDGMLFGDETLISKDEELQ----ERLSLAVLKNM-DKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPSPIDITPVPPADFEVRVVVKNLVGIQAGDKNIFGKLMS-DVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMVIRRKAGL-LEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR--KRINLFKRKVINGWFPLQSNAH--PSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPPYRPDSSFNPLTHPCKSFQHIL 1609          

Query:  670 KDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTS------GEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAIL---GDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLY 1563
            ++F I +T+++A  +          +   K  + T+    T  PF+NEYF F+F  +  EL+   I  +    K H+  +      V+GE  +D  +V++  +H +F KW  L  P              G++++DL+++ +   P       +E+D        +       ++++            L  +N    SNI+  +    G     ++  ++VSFAG+ G T V+  + +P WN +I F   +P    R  I +   + ++ + ++   + L +I  +         P+ GP++++LY
Sbjct:   13 QEFLICITVHKAAQVGVTTGELYVRISLDKMTKSTKSFPNTENPFFNEYFVFEFHCTLTELLRLTILFEL---KKHMTYKK---NVVVGELLVDLHSVWNQSNHGYFKKWGRLEAPIGENQTLENAVAPHGYLQLDLAIV-SQHSPVSYALGSEEQDTQNLNKWTVDHDFDDIEKNL------------LTNVNIFAPSNIRYFVAFYRGYFIKQSNYMIQVSFAGFNGKTPVVKNTTTPVWNYEINFAWMYPSVAQRFLILIFAHEHLQWKCVAEFELCLEEIAFNGT-------PSLGPTYLHLY 293          

Query: 4561 SVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPEC--KLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKP 5913
            +V  +VRVYVV+G+ + P D+ G +D Y+ + +G K   DR ++ P   NP+FGR FEME T P +  L V VYD D++ KD++IG+T IDLE+RW + HR T GL + Y   GY  W D +LP+ IL  LC+K  I  P Y    + +E+ G  F  +++I  D+  Q    E L+L VL N  D +P    KLV EH+ETR L   + P +EQG L++W+++F +   +P PIDI+P  PA +E+R+V+     ++  D N F K  S D+Y+  W +  D   Q TD H+RS +G   FNWR VF   Y   ED +V + K    ++E E+K P  + +QV D D+L  D  +  L+  LS    P    + C P+       + NLFK K + GW+PL  N      +        G +++ +++    EA + PAG G++ P+ LE P
Sbjct:  608 TVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKI-KDEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYY--YGNVIEVDGMLFGDETLISKDEELQ----ERLSLAVLKNM-DKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPSPIDITPVPPADFEVRVVVKNLVGIQAGDKNIFGKLMS-DVYVIGWCEDED-KRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMVIRRKAGL-LEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKR--KRINLFKRKVINGWFPLQSN--AHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPP 1045          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKT-KPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEY------------------------------NSPVSGNENL-----GKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEP---SDDIDVK--------DGDNYSELSL------LPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIK-----TTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYS-----------------------HLPKKEENFESQYVHSL--TEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIE--YYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSD-----AKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATL 3918
            M+L+V L+++T ++   +   KV FR   F +   +  +        F WPI  ++D  + L I+    ++   ++L G   +VL  ++ +  + + +T +D+        ++ EI+Y                              +S +SG         G+S   +P++   K  +          T + + D   GD+     ++D+D K        D D  S  S+      +  +  K    ++P S +  D+QISVT+ EAR L G N++P+  V  G++K+ T +K  TN P+YNEYF FDF +    + ++II+I  +  K+ + +     G ++G F +D  TVY+   H F +KWA+L DP   T+G KG+VK D++V+  GD  K P+K  + ++ +IE N+L+P+ +  ++R      V +Y+AE LP MNT IM+N+K+A +G+ + L DPYV V FAG  G T V   SY P WN+Q+IFTE FPP   RL++ +RDSD + D  I T FIDL K+ N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLLI+I      TTS        V +   + +S +  GK E + LF S  EAT+I ++IG   KP++FE++IG  G   D  S                       H   +EE  +   + S+  T P      D  YFH+PY  KKPC+Y+ +  +D R RL+  NI+DK+  +L E +  V  +  + +K    R ++  +E    S  + ++     +  + +T LD +  K     +E M          +   T+   +K + +F++ L     +PQH +PDVF++MI +N R+AY RI ++D+++S +  E G+ CG V  V+L+      LP K       + +QA+L++YLWLGL K  + + +GLP GF      K      +PP  + Y  +  FQLR ++Y  R+L  +D SGLSDPF +V    H + + V  ET  P WD+ ++ DN+        ++  PP +V+E++D D+    EFIGR F +P   +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  +       P ++          D+ +G      L +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I+++  +PNF+  +    + LP N    PP++I  ++   FG   +VG+H +T L +  Y   DK   +  H  D + +++ + ++K     V  +A           T A VK D      + +       + E++    P E M   DWW++Y+A++
Sbjct:    1 MALVVHLKTVTELRGKGDRIAKVTFRGLSFFSRVLENCEDEARFEQAFRWPIGSQVDGDEMLEIQVFNYSKVFTNRLIGTFRMVLQKVVEEGHLEVSDTLIDDNNTAIQTTISIEIKYQTMDGSVKVWSDGEFLDIPDDLDGTFQFETDSLLSGRSQSSGTSPGRSIHGIPTFR--KAGKGVFSAMKLGKTRTSKDDHKKGDDAAILDAEDLDRKAMRLGGILDPDTISLASVTAVTTNVSNKRSKPDIKMEPSSGRPVDYQISVTVIEARQLVGLNMDPVVCVEIGEEKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKIIKISVIHSKNLLRS-----GTLVGTFKLDVGTVYTQPEHQFHHKWAMLSDPDDITTGCKGYVKCDIAVVGKGDNIKTPHKASEADEDDIEGNLLLPEGV-PSERQWARFYVKIYRAEGLPKMNTSIMANVKKAFIGENRDLVDPYVLVQFAGQKGKTSVQKSSYEPIWNEQVIFTEMFPPLCRRLKVQIRDSDKVNDVAIGTHFIDLRKVSNDGDK---GFLPTMGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLISIAVEILDTTSAEIMSSTEVHMEPVSNISESATGKMEEFFLFGSFLEATMIDRKIGD--KPISFEVTIGNYGNQIDGVSKPALAKKKKEGGGESEEEESELIHNSSEEEAEDDGDLTSVPSTPPMKPVITDRNYFHLPYFEKKPCIYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEII-KTEKAYPERRLRGVLEELSTSCSRFVTLANKDQNLSGRTKLDRERLKSCMREMESMGQQAKTIRTQVKRNTVRDKLKLVLNFLQRLRFLADEPQHSIPDVFIWMISNNKRIAYARIPSKDILYSIVDEEMGKDCGKVKAVFLR------LPGKKGFGPAGWTVQAKLEMYLWLGLNKQRKDFLIGLPSGFEENKAVKGIGIQAVPPISLVYNMKQVFQLRAHMYQARSLFAADTSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDNVELYGEAGELRDDPPIIVIELYDQDTVGKAEFIGRTFAKPLTKMVDEHYGPPRFPPQLEYYQIYRGNCAAGDLLAAFELLQIGPAGR----AALPPIDG-------PTDSDRG----PILPVPLGIRPVLSRYRIEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYILVGSHAVTTLRKFIYSPPDKTANNWAHTGDIVVNMSPEPNIKKMDTVVKIEA----------TTDAVVKVDLNEDEKEKEKKKKKKKKGEEVEEEEPDESM--LDWWSKYFASI 1326          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEI-QDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYR 5985
            ++ + +Y+ ELE+  ++G F+    +F+LYRGK  ++DD   + +DR  G FKG++C+Y +   + I  +  FD +                             +  F S PH+  ++ +VR+Y+++  +LHPADINGKADPYI++++G  +IRD+ENYI K LNP+FG+ F++E TFP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+ S Y+ HGY  W+D Q P  IL  LC++  +  P Y      V++  + F   + IED+ G + ++ E LAL VL +WE+I P   CKL+ EH+ETRPL   +KPGIEQG +EMWVDMFP     P P IDISPRKP  YELR++I  T+ V L D ++FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRFVF FDYL AE+ IV  K ++++  DE EYK P  L +QV D+D   +D  +G ++  L+KFP+ AK  K C  D           ++FK K+V+GWWP V       + E +  E+ G VE E+ L+  EEAE +P GLGR +P PLEKPNRPD +FL FL+P   I+Y I  R
Sbjct: 1399 VDELMVYNKELES--EFGSFEDWLHTFNLYRGKAGDDDDHNVVDEDRIVGRFKGSLCMYKLPLSEEITREAGFDPN-----------------------------MGMFQSIPHNDPINVLVRIYIIRATDLHPADINGKADPYIVIKLGKSDIRDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGIASNYSVHGYNVWRDPQKPAQILAKLCKEGKLDGPHYGP-GGRVKVANRIFLGPTEIEDESGLKKQTEEHLALTVLRHWEEI-PRVGCKLIPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDVPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNKFPRGAKTAKQCSLDMVLKEHELPTISIFKQKRVKGWWPFV------AQNENDEFELTGKVEAELHLLTAEEAEKSPVGLGRNDPEPLEKPNRPDTTFLWFLSPLKAIRYLICNR 1956          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKT-KPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEY------------------------------NSPVSGNENL-----GKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEP---SDDIDVK--------DGDNYSELSL------LPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIK-----TTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYS-----------------------HLPKKEENFESQYVHSL--TEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIE--YYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSD-----AKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATL 3918
            M+L+V L+++T ++   +   KV FR   F +   +  +        F WPI  ++D  + L I+    ++   ++L G   +VL  ++ +  + + +T +D+        ++ EI+Y                              +S +SG         G+S   +P++   K  +          T + + D   GD+     ++D+D K        D D  S  S+      +  +  K    ++P S +  D+QISVT+ EAR L G N++P+  V  G++K+ T +K  TN P+YNEYF FDF +    + ++II+I  +  K+ + +     G ++G F +D  TVY+   H F +KWA+L DP   T+G KG+VK D++V+  GD  K P+K  + ++ +IE N+L+P+ +  ++R      V +Y+AE LP MNT IM+N+K+A +G+ + L DPYV V FAG  G T V   SY P WN+Q+IFTE FPP   RL++ +RDSD + D  I T FIDL K+ N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLLI+I      TTS        V +   + +S +  GK E + LF S  EAT+I ++IG   KP++FE++IG  G   D  S                       H   +EE  +   + S+  T P      D  YFH+PY  KKPC+Y+ +  +D R RL+  NI+DK+  +L E +  V  +  + +K    R ++  +E    S  + ++     +  + +T LD +  K     +E M          +   T+   +K + +F++ L     +PQH +PDVF++MI +N R+AY RI ++D+++S +  E G+ CG V  V+L+      LP K       + +QA+L++YLWLGL K  + + +GLP GF      K      +PP  + Y  +  FQLR ++Y  R+L  +D SGLSDPF +V    H + + V  ET  P WD+ ++ DN+        ++  PP +V+E++D D+    EFIGR F +P   +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  +       P ++          D+ +G      L +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I+++  +PNF+  +    + LP N    PP++I  ++   FG   +VG+H +T L +  Y   DK   +  H  D + +++ + ++K     V  +A           T A VK D      + +       + E++    P E M   DWW++Y+A++
Sbjct:    1 MALVVHLKTVTELRGKGDRIAKVTFRGLSFFSRVLENCEDEARFEQAFRWPIGSQVDGDEMLEIQVFNYSKVFTNRLIGTFRMVLQKVVEEGHLEVSDTLIDDNNTAIQTTISIEIKYQTMDGSVKVWSDGEFLDIPDDLDGTFQFETDSLLSGRSQSSGTSPGRSIHGIPTFR--KAGKGVFSAMKLGKTRTSKDDHKKGDDAAILDAEDLDRKAMRLGGILDPDTISLASVTAVTTNVSNKRSKPDIKMEPSSGRPVDYQISVTVIEARQLVGLNMDPVVCVEIGEEKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKIIKISVIHSKNLLRS-----GTLVGTFKLDVGTVYTQPEHQFHHKWAMLSDPDDITTGCKGYVKCDIAVVGKGDNIKTPHKASEADEDDIEGNLLLPEGV-PSERQWARFYVKIYRAEGLPKMNTSIMANVKKAFIGENRDLVDPYVLVQFAGQKGKTSVQKSSYEPIWNEQVIFTEMFPPLCRRLKVQIRDSDKVNDVAIGTHFIDLRKVSNDGDK---GFLPTMGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLISIAVEILDTTSAEIMSSTEVHMEPVSNISESATGKMEEFFLFGSFLEATMIDRKIGD--KPISFEVTIGNYGNQIDGVSKPALAKKKKEGGGESEEEESELIHNSSEEEAEDDGDLTSVPSTPPMKPVITDRNYFHLPYFEKKPCIYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEII-KTEKAYPERRLRGVLEELSTSCSRFVTLANKDQNLSGRTKLDRERLKSCMREMESMGQQAKTIRTQVKRNTVRDKLKLVLNFLQRLRFLADEPQHSIPDVFIWMISNNKRIAYARIPSKDILYSIVDEEMGKDCGKVKAVFLR------LPGKKGFGPAGWTVQAKLEMYLWLGLNKQRKDFLIGLPSGFEENKAVKGIGIQAVPPISLVYNMKQVFQLRAHMYQARSLFAADTSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDNVELYGEAGELRDDPPIIVIELYDQDTVGKAEFIGRTFAKPLTKMVDEHYGPPRFPPQLEYYQIYRGNCAAGDLLAAFELLQIGPAGR----AALPPIDG-------PTDSDRG----PILPVPLGIRPVLSRYRIEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYILVGSHAVTTLRKFIYSPPDKTANNWAHTGDIVVNMSPEPNIKKMDTVVKIEA----------TTDAVVKVDLNEDEKEKEKKKKKKKKGEEVEEEEPDESM--LDWWSKYFASI 1326          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEI-QDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            ++ + +Y+ ELE+  ++G F+    +F+LYRGK  ++DD   + +DR  G FKG++C+Y +   + I  +  FD +                             +  F S PH+  ++ +VR+Y+++  +LHPADINGKADPYI++++G  +IRD+ENYI K LNP+FG+ F++E TFP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+ S Y+ HGY  W+D Q P  IL  LC++  +  P Y      V++  + F   + IED+ G + ++ E LAL VL +WE+I P   CKL+ EH+ETRPL   +KPGIEQG +EMWVDMFP     P P IDISPRKP  YELR++I  T+ V L D ++FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRFVF FDYL AE+ IV  K ++++  DE EYK P  L +QV D+D   +D  +G ++  L+KFP+ AK  K C  D           ++FK K+V+GWWP V       + E +  E+ G VE E+ L+  EEAE +P GLGR +P PLEKPNRPD S + F+NP  +I+YFI
Sbjct: 1399 VDELMVYNKELES--EFGSFEDWLHTFNLYRGKAGDDDDHNVVDEDRIVGRFKGSLCMYKLPLSEEITREAGFDPN-----------------------------MGMFQSIPHNDPINVLVRIYIIRATDLHPADINGKADPYIVIKLGKSDIRDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGIASNYSVHGYNVWRDPQKPAQILAKLCKEGKLDGPHYGP-GGRVKVANRIFLGPTEIEDESGLKKQTEEHLALTVLRHWEEI-PRVGCKLIPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDVPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNKFPRGAKTAKQCSLDMVLKEHELPTISIFKQKRVKGWWPFV------AQNENDEFELTGKVEAELHLLTAEEAEKSPVGLGRNDPEPLEKPNRPDTSLMWFMNPLRSIRYFI 1953          

Query:  535 DSDNGDNEPS----DDIDVKDGDNYSELSL------LPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPDSI-KIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKE-----ENFESQYVH----------------SLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSF---VKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            D   G +EP+    +D+ + D D  S  S+      +  +  K    I+P + +  DFQ+SVT+ EAR L G N++P+  V  G  K+ T +K  TN P+YNEYF FDF +    + ++I+++  +  K+ + +     G ++G F +D  T+Y+   H FF+KWA L DP+  T+G KG+VK D++V+  GD  K P+K ++ ++ +IE+N+L+P+ +   +R      + +Y+AE LP MNT IM+N+K+A +G+ K L DPYV+V FAG  G T +   SY P WN+QI+FTE+FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R+Y+   ++   Q  N+ L EGV+FR RLLI++      TS P+ +    V V     +S+N  GK E + LF S  EAT+I ++IG   KP+ FE++IG  G   D  +    K+     ++ ES+ +H                S T P      D  YFH+PY  +KPC+Y+ +  +D R RL+  N+LDK+  +L E +  V  +  + +K    R ++  +E    S    +S   + +  A +T LD +  KL    +E M          +    +   IK   +F   ++FL D   +PQH +PD++++MI +N R+AY R+ ++D+++S++  E G+ CG V T++ K      LP K       + +QA+ ++YLWLGL +  + Y  GLP GF      K       PP  + Y  +  FQLRV++Y  R+L  +D +GLSDPF ++    H + + V +ET  P WD+ ++ D++        ++  PP +V+EI+D D+    +F+GR F +P   +  + Y   +    L+++ +YRG   AG++L +F+L++I P  K       P ++          D  +G      L +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I+++  +PNF+  +    + LP N    PP++I  ++   FG   +VG+H +T L ++
Sbjct:   11 DDGKGQDEPAILETEDMRMPDPDTISLASVTAVTTNVSNKRSKPDIKIEPSAGRPMDFQVSVTVIEARQLVGLNMDPVVCVEIGDDKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKILKVSVIHSKNLLRS-----GTLVGSFKLDVGTIYTQPDHQFFHKWATLCDPEDITAGLKGYVKCDIAVVAKGDTIKTPHKANENDEDDIESNLLLPEDV-PAERQWARFYLKIYRAEGLPKMNTSIMANVKKAFIGENKDLVDPYVQVLFAGQKGKTSIQKSSYEPIWNEQIVFTEQFPPLCRRMKLQIRDSDKVNDVAIGTHFIDLRKIANDGDK---GFLPTLGPAWVNMYGSTRSYT---LMDEYQDLNEGLGEGVSFRARLLISLAVEILDTSSPEVMSSTEVQVEGIPNISDNATGKVEEFFLFGSFLEATMIDRKIGD--KPINFEVTIGNYGSELDTPTKPKSKKKKGDGDDEESELIHGSSDEEVDDGGDVTSVSTTPPMKPVITDRNYFHLPYFERKPCIYIYSWWQDQRRRLYNANVLDKMADKLEEGLNDVQEII-KTEKAYPERRLRGVLEELSNSCSTFVSLANNDQNQAGRTKLDKERVKLCMQEVESMGQQAKTMRSQVKKSNVKDRIKLAQNFLHKLRFLSD---EPQHSVPDIYIWMISNNKRIAYARVPSKDILYSSVEEECGKDCGKVQTIFFK------LPGKKSFGPAGWTVQAKTELYLWLGLNRQRKDYLCGLPNGFEENKAVKGPGVQSSPPISLMYTMKQIFQLRVHMYQARSLFAADSTGLSDPFARIFFSTHSQVTEVLNETLCPTWDQLLVFDHVELYGEAGELRDDPPIIVIEIYDQDTVGKADFMGRTFAKPITKMSDEHYGPPRFPPQLEYYQIYRGNCTAGEMLAAFELLQIGPGGK----ADLPPIDG-------PTDIDRG----PILPVPIGIRPVLSKYRIEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVTTLRKF 1042          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEE---DDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            IE  K+Y+ ELE   +Y  F+    +F+L+RGK  ++   D     +DR  G FKG++CIY V  D++     FD +                             +  F + PH+  ++ +VR+YVV+  +LHPADINGKADPYI +++G  EI+D+ENYI K LNP+FG+ F++E T P +S L V +YDWD +  DDLIGET IDLENR+ S HR TCG+ STY  HGY  W+D   P+ IL  LC+   I  P+Y      V++  + +   + +ED++G + ++ E LAL VL++WEDI P   CKLV EH+ETRPL   +KPGIEQG +EMWVDMFP   + P P +DISPRKP  +ELR+++  T+ V L D + FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRF++ FDYL+AE+ IV  K ++++  DE EYK P  LN+QV D+D   +D  +G ++  L++FP+ AK  K C  +   + +     N+FK K+++GWWP V   +       + LEI G VE E+ L+ GEEAE +P G GR EP PLEKPNRPD +FL F+ P   I++ +
Sbjct: 1179 IEEFKVYNRELE--YEYNQFEDWLHTFNLHRGKCSDDADVDQNAADEDRLIGKFKGSLCIYKVSSDDMSRDMGFDSN-----------------------------MGMFQNIPHNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKSEIKDKENYISKQLNPVFGKSFDVEATLPMDSTLTVSIYDWDLVGTDDLIGETKIDLENRFYSKHRATCGISSTYAIHGYNVWRDPLKPSHILAKLCKDGKIDAPQYGP-GGRVKVTNRVYTGPTEVEDENGLKKQTDEHLALAVLNHWEDI-PRIGCKLVPEHMETRPLLNPDKPGIEQGRIEMWVDMFPKDMSAPGPALDISPRKPKKFELRVIVWNTDEVVLEDDDIFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFIYPFDYLQAEEKIVISKKESMFSWDETEYKIPARLNLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIEMVTNENEMPMVNIFKQKRIKGWWPFVARDE------NDELEITGKVEAELQLLTGEEAEKSPVGEGRNEPEPLEKPNRPDTAFLWFMMPLKAIRHLV 1734          

Query: 4240 IYSCELENIKDYGGFKQPFRSFSLYRGKQEEED-DGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIV-PECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIVD 6090
            +Y  ELE   ++G F    ++F L+RGK  EED   YE   RF G FKG  C+Y + E         D + +E  + S                    K+ + +    +V+ ++RVY+    NLHPAD +GKADPYI++++G  EI+DR+NYIPK LNP+FGR FE + TFP+ES L + +YD+D +  DDLIGET IDLENR+ S HR TC L + Y   GY  W+D   P  +L  LC++N +  P++      + I  K F   ++  D+D   ++S E LAL VLH W ++    CKLV EHIETR LYL++KPGI+QG L+MWVD+FP     P PP+DISPRKP  YELRI+I  TE+V L DTNF T ++S DIY+K W+K  + D Q+TD H+ SL+G+G FNWRFVF F YL AE  +V  K ++IY +D+ E K P  L MQV D + L SD  +G ++  L  FP+ AK  K+C     ++     ++F+ K+ +GWWP +              E+ G VE E  LV  EEAE NP G  R+EP PLEKPNRPD SF  F+NP+    + I    K  +I  L++LI  L +VL  Y  PG  S  IV+
Sbjct:    1 VYDKELE--AEFGPFDDWVKTFELFRGKANEEDGSAYE---RFVGKFKGRFCLYKLPEA--------DGEAEEGYVDS-----------------GQFKINQGIPPNTAVNVLIRVYIA--FNLHPADPDGKADPYIVLKLGKTEIKDRDNYIPKQLNPVFGRSFEFQATFPKESLLTILIYDYDLVGGDDLIGETQIDLENRFYSRHRATCSLPTEYAIEGYNAWRDCMKPVDLLIKLCKENRLDNPQFSP--GRITIGNKVFMGKTVFPDED-QMVESYEHLALKVLHRWSEMPNGGCKLVPEHIETRALYLKDKPGIDQGHLQMWVDIFPLDMPHPGPPVDISPRKPKGYELRIIIWNTEDVILEDTNFITGQQSSDIYVKGWLKGLEDDGQETDVHYNSLTGEGNFNWRFVFPFSYLPAEKVVVVQKRESIYSLDKTEQKMPAVLVMQVWDFERLSSDDFLGSVELDLHGFPRGAKSAKACKMEMLTELTENISIFQQKRSKGWWPFI-----------KAGELTGKVEAEFHLVTAEEAEKNPVGRARKEPEPLEKPNRPDTSFSWFMNPFKCFFHLIWGNYKKYIIAGLVLLILTLFLVLLFYTLPGALSTKIVN 575          

Query:  664 KIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGD-KPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT--------------------------------TSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKE------------ENFESQYVHSLTEPKYAYTFDNQ--YFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLS-AIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIE----CLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH--KDCFTSK--MPPKIIDYMEESD-FQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDL 3627
            K ++FQIS+ I E R L G NI+P   +  G  K+ T +K  TN PFYNEYF FD   ++    +++I++  +  K       I     +G F ID  TVYS   H F  KWA L DP     G KG++K D+SV   GD  P     +D EE   I+ ++L+P+ L   +R      V VY+AE LP +N+ IM+N+ +A +GD  AL DPYVEVSF G  G T     S  P WN+Q++F E FPP   RL+I V D   + D  I T +IDLH I N  + +  GFLPT+GP+WINLYG+ R    + ++   Q  N+ + EGV++RGRL I +                                    +  S  IG +V    P         E +LLF  +FEA++I ++IG +  P+T E +IG  G   D  +  P K+            +   +    S T P+     D Q  Y H+P  ++KPC+Y+ +  ED   RL   N+LD +     E V +V  L  +    +A   +   +  F     + ++ A K  +G+   TLLD K   + +  LE M       +E     L+V  + +  + +   ++FL +   +PQH LPDVF+ ++ +N RVAY RI ARDL+ S  P ++G+ CG + T++LK      + +   + +QA+L ++LWLG   +       LP GF      F  +   PP+ + Y  ++  F+LR ++Y  R LI +D++GLSDPF  V    H + + +  +T +P W++ I + N+        +   PP +V+E++D D     E++G     P V +  ++Y+  +LQ+  ++ G++  GDIL +F+LI+    S        P L+               E D   + +P  +RP +  +R+E+L WG+R+L++++++S                V++P++ I+  G  + S +I+ +  +PNF   + +  + LP +    PP+++  +++  FG   +VG+HVI +L
Sbjct:  102 KPQNFQISINITEIRQLVGDNIDPSVVIEIGDDKKQTSVKEGTNAPFYNEYFVFDIYCNQDIFFDKVIKLSVMHSK-------IMKSYCVGTFKIDVGTVYSQPGHQFINKWATLTDPADIRVGVKGYLKCDISVSGKGDVAPPSQKFSDAEE--QIDKHLLLPEGL-NPERPWARFYVIVYRAEGLPRINSSIMANVTKAFVGDTTALIDPYVEVSFFGQVGRTSTQKSSADPVWNEQVVFKEMFPPLCQRLKIRVLDEGSMNDVAIGTHYIDLHTISNDTDGDN-GFLPTFGPAWINLYGSLRN---STLVDDSQELNEGVGEGVSYRGRLYIELSVEILSGGAAESKSLLSKFSPKDAKGGKTGTGAGGEEEKSKMIGPEVIPVEPPQKMRDEDMETFLLFGCVFEASMIDRKIGDR--PVTLEFTIGNFGNLIDGAAPPPSKKKLEDVSVTAPLLDTTATMPCKSTTTPERPIFGDAQRHYMHLPIAAQKPCVYVYSSWEDRAYRLHHANMLDTIALMFEEGVAKVTEL-DKMLSPEAWSLMHHVLREFRRDAKEFIAFAEKKVKGS-NLTLLDKKRLTMCKQELESMTEMAGGLLEPKRRSLTVKEMLLEAQKIKKKLRFLVE---EPQHTLPDVFVCLVSNNKRVAYARIPARDLLFSESPEQRGRDCGKIKTLFLK----PPVKRAPGWTVQAKLDVFLWLGTCAESSRMLDNLPSGFELVSTSFEDRTGAPPEYLLYTGKTHMFELRAHMYQARGLIAADNTGLSDPFAWVSFLSHSQCTGIIKQTLTPTWNQVIKMTNMSLYGGLYDIAQEPPLIVIEVYD-DDAVGSEYLGSTVAVPVVKLSEEQYSPPQLQYSPLFCGSLSGGDILGAFELIQSGEHS-------LPVLD---------------EPDGVVIPVPSYIRPVLCKYRIEVLFWGLRELKKVQLLS----------------VDRPQVFIKCAGSGVNSSVIQSYKKNPNFTIIVDAFDVELPEDEHLLPPLTLTVVDWRAFGRSTLVGSHVINNL 1082          

Query: 4132 LFQHKSTKELFLKEVQEHLILEDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEED-DGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIV-PECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIVD 6090
            LF++ S      KEV    ++E  +L+       +++Y  ELE   ++G F    ++F L+RGK  EED   YE   RF G FKG  C+Y + E +   ++ +  D  + K+                         + +    +V+ ++RVY+V   NLHPAD +GKADPYI++++G  EI+DR+NYIPK LNP+FGR FE + TFP+ES L + +YD+D +  DDLIGET IDLENR+ S HR TC L + Y   GY  W+D   P  +L  LC++N +  P++      + I  K F   ++  D+D   ++S E LAL VLH W ++    CKLV EHIETR LYL++KPGI+QG L+MWVD+FP     P PP+DISPRKP  YELRI+I  TE+V L DTNF T ++S DIY+K W+K  + D Q+TD H+ SL+G+G FNWRFVF F YL AE  +V  K ++IY +D+ E K P  L MQV D + L SD  +G ++  L  FP+ AK  K+C     ++     ++F+ K+ +GWWP +              E+ G VE E  LV  EEAE NP G  R+EP PLEKPNRPD SF  F+NP+    + I    K  +I  L++LI  L +VL  Y  PG  S  IV+
Sbjct: 1183 LFENTSGMRDRKKEVNYKSVIEQPRLA------TLQVYDKELE--AEFGPFDDWVKTFELFRGKANEEDGSAYE---RFVGKFKGRFCLYKLPEADGEAEEGY-VDSGQFKI------------------------NQGIPPNTAVNVLIRVYIVAAFNLHPADPDGKADPYIVLKLGKTEIKDRDNYIPKQLNPVFGRSFEFQATFPKESLLTILIYDYDLVGGDDLIGETQIDLENRFYSRHRATCSLPTEYAIEGYNAWRDCMKPVDLLIKLCKENRLDNPQFSP--GRITIGNKVFMGKTVFPDED-QMVESYEHLALKVLHRWSEMPNGGCKLVPEHIETRALYLKDKPGIDQGHLQMWVDIFPLDMPHPGPPVDISPRKPKGYELRIIIWNTEDVILEDTNFITGQQSSDIYVKGWLKGLEDDGQETDVHYNSLTGEGNFNWRFVFPFSYLPAEKVVVVQKRESIYSLDKTEQKMPAVLVMQVWDFERLSSDDFLGSVELDLHGFPRGAKSAKACKMEMLTELTENISIFQQKRSKGWWPFI-----------KAGELTGKVEAEFHLVTAEEAEKNPVGRARKEPEPLEKPNRPDTSFSWFMNPFKCFFHLIWGNYKKYIIAGLVLLILTLFLVLLFYTLPGALSTKIVN 1789          

Query:  247 FILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGN------------ENLGKSDFNVPSYNLTKLERHEGHIRLPS--------------DTSSVESDSDNGDNEPS----DDIDVK--------DGDNYSELSL------LPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIF-PGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTE-----------------------PKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEK---LRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIE--YYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDV------------TNPVPGEPEKLIRFVPKEEMESADWWTRYYATL 3918
            + +  RFG  +L G   +VL  ++ +  + + +T +D+       +++ E+ Y + + G+             NL       P + +    R   + RLP                 +    D     +EP+    +D+D K        D D  S  S+      +  +  K    ++P + +  D+Q+S+T+ EAR L G N++P+  V  G +K+ T +K  TN P+YNE       +S       + R +A+ K S I ++++   G ++G F +D  TVY+   H F++KWA+L DP   T+G KG++K D++V+  GD  K P+K ++ ++ +IE N+L+P  +   +R      V +Y+AE LP MNT IM+N+K+A++G+ K L DPYV+V+FAG  G T V   SY P WN+QIIFTE FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT+GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLL+++      T+ P+ +    V +    PV+    GK E + LF +  E+T+I ++IG K  P+ FE++IG  G   D  S    ++       V   TE                              D  YFH+P+  KKPC Y+ +  +D R RL+  NI+DK+  +L E +  V+ +  + +K    R ++  +E    S  + ++     +    +T LD +  K     LE M          +   T+   +K + +F++ L     +PQH +PD+F++M+ +N R+AY RI ++D+++S +  E G+ CG V  V+LK      LP K       + +QA++++Y+WLGL K  R +  GLP GF      K       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DNI        ++  PP +V+EI+D D+    +F+GR F +P V +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  K       P +E              G  D E+   L +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I+++  +PNF+  +    + LP N    PP++I  ++   FG   +VG+H ++ L    Y   DK ++     +  +    A  + +  S        + + E   +K +  VK +A   V                    E++    P E M   DWW++Y+A++
Sbjct:   46 YCVFLRFGA-RLIGTFRMVLQQVVEEAQLEVTDTLIDDNNSAIRTSVSIELRYQT-MDGSVGAWNDGEFMDGTNLQSESMATPLWPVPTPHRTLSNRRLPLICRVGKGVFSAMKLGKTRPPKDESRKQDEPAVLETEDLDRKAIRLAGGLDPDTISLASVTAVTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDEKKYTSMKESTNCPYYNE-------VSATVPTSPVPRDRAV-KVSVIHSKNLLRSGTLVGSFKLDVGTVYTQPEHQFYHKWALLSDPDDITAGLKGYLKCDIAVVGKGDNIKTPHKANETDEDDIEGNLLLPDGV-PAERQWARFYVKIYRAEGLPRMNTSIMANVKKALIGENKDLVDPYVQVAFAGQKGKTSVQKSSYEPMWNEQIIFTEMFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKIANEGDK---GFLPTFGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLLSLAVEILDTTNPELTSSTEVQIEGAQPVAETCTGKMEEFFLFGAFLESTMIDRKIGDK--PINFEVTIGNYGNQIDGISKPSMRKRKEGGDGVEEETELLQNSSDDEADEDGEMLSISSSPAMKPLITDRNYFHLPFFDKKPCTYIKSWWQDQRRRLYNANIMDKIADKLEEGLNDVHEMI-KTEKPYPERRLRGVLEELSSSCFRFVTLANKDQNQNGQTKLDRERLKSCMRELENMGTQAKTMRSQVKKNTVKDKLKLVQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRIAYARIPSKDILYSIVDEETGKDCGKVKCVFLK------LPGKRGFGPAGWTVQAKMEVYMWLGLSKQRRDFLCGLPCGFEEIKAVKGPGLQSFPPISLSYTKKQVFQLRAHMYQARSLFAADSSGLSDPFARVFFNTQSQCTEVLNETLCPTWDQLLVFDNIELYGEAHEMRDDPPIIVIEIYDQDTVGKADFMGRTFAKPVVKMSDERYCPPRFPPQLEYYQIYRGNSTAGDLLGAFELLQIGPAGKS----DLPQIE--------------GPTDIERGPILPVPLGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGRGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDKNSQQWTTAAKLMNGYLAMTNGRPRSRTTGEIVINMEPEAPVKKMETMVKLEAVSSVFILLGGEEEKDKKKKKKKGVEEIEEEEPDESM--LDWWSKYFASI 1311          

Query: 4240 IYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCD-PFQHSDA-CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +Y+ ELE   +Y  F+    +F+L RGK  ++DD    ++R  G FKG++C+Y V   +++ ++  +D         +FG                      F   P++  ++ +VRVYVV+  +LHPADINGKADPY+++++G  +I+D+ENYI K LNP+FG+ F++E TFP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY  HGY  W+D   PT IL  LC++  I  P Y      V++  + F   + I+D++G + ++ E LAL VL +WEDI P   CKLV EH+ETRPL   +KPGIEQG +EMWVDMFP     P P IDISPRKP  YELR++I  T+ V L D ++FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRF+F FDYL AE+ IV  K ++++  DE EYK P  L +QV D+D   +D  +G ++  L++FP+ AK  K C       D      ++FK K+V+GWWP V         E + +E+ G VE E+ L+  EEAE  PAGLGR EP PLEKPNRPD SF+ FLNP  +I+YFI
Sbjct: 1333 VYNKELET--EYDNFEDWLHTFNLLRGKIGDDDDTVSEEERIVGRFKGSMCVYKVPLPEDVTKEAGYD--------PNFG---------------------MFQGIPNNDPMNVLVRVYVVRATDLHPADINGKADPYVVIKLGKTDIKDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGISKTYAIHGYNLWRDPVKPTQILSKLCKEGKIDGPHYGP-GGRVKVTNRVFTGPTEIDDENGQKKQTDEHLALSVLQHWEDI-PRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDMPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFLFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIEMAEPDVDLPMVSIFKQKRVKGWWPFV------ARNENDEMELTGKVEAELHLLSAEEAEKTPAGLGRNEPDPLEKPNRPDTSFIWFLNPLKSIRYFI 1881          

Query:  697 YEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTE-----------------------PKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQ-AMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIE-IDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEK---LRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDL 3627
            ++AR L G N++P+  V  G +K+ T +K  TN P+YNE       +S       +I  K L +           G ++G F +D  TVY+   H F++KWA+L DP   T+G KG++K D++V+  GD  K P+K ++ ++ +IE N+L+P  +   +R      V +Y+AE LP MNT IM+N+K+A++G+ K L DPYV+V+FAG  G T V   SY P WN+QIIFTE FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT+GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLL+++      T+ P+ +    V +    PV+    GK E + LF +  E+T+I ++IG K  P+ FE++IG  G   D  S    ++       V   TE                              D  YFH+P+  KKPC Y+ +  +D R RL+  NI+DK+  +L      + YL  +G + + A    +   E        V       R T         + +   MG +   M   V        T+   +K + +F++ L     +PQH +PD+F++M+ +N R+AY RI ++D+++S +  E G+ CG V  V+LK      LP K       + +QA++++Y+WLGL K  R +  GLP GF      K       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DNI        ++  PP +V+EI+D D+    +F+GR F +P V +  + Y   +    L+++ +YRG   AGD+L +F+L++ I P  K       P +E              G  D E+   L +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I+++  +PNF+  +    + LP N    PP++I  ++   FG   +VG+H ++ L
Sbjct:    3 FKARQLVGLNMDPVVCVEVGDEKKYTSMKESTNCPYYNE-------VSATVPTSPVIHSKNLLRS----------GTLVGSFKLDVGTVYTQPEHQFYHKWALLSDPDDITAGLKGYLKCDIAVVGKGDNIKTPHKANETDEDDIEGNLLLPDGV-PAERQWARFYVKIYRAEGLPRMNTSIMANVKKALIGENKDLVDPYVQVAFAGQKGKTSVQKSSYEPMWNEQIIFTEMFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKIANEGDK---GFLPTFGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLLSLAVEILDTTNPELTSSTEVQIEGAQPVAETCTGKMEEFFLFGAFLESTMIDRKIGDK--PINFEVTIGNYGNQIDGISKPSMRKRKEGGDGVEEETELLQNSSDDEADEDGEMLSISSSPAMKPLITDRNYFHLPFFDKKPCTYIKSWWQDQRRRLYNANIMDKIADKL-----SICYLGQQGPEPEWADETGQGEAEVLHEGAGNVFVLEGLGRLTGDGLTNHDCFAQQENMGTQAKTMRSQVKKN-----TVKDKLKLVQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRIAYARIPSKDILYSIVDEETGKDCGKVKCVFLK------LPGKRGFGPAGWTVQAKMEVYMWLGLSKQRRDFLCGLPCGFEEIKAVKGPGLQSFPPISLSYTKKQVFQLRAHMYQARSLFAADSSGLSDPFARVFFNTQSQCTEVLNETLCPTWDQLLVFDNIELYGEAHEMRDDPPIIVIEIYDQDTVGKADFMGRTFAKPVVKMSDERYCPPRFPPQLEYYQIYRGNSTAGDLLGAFELLQVIGPAGKS----DLPQIE--------------GPTDIERGPILPVPLGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGRGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSL 950          

Query: 4240 IYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCD-PFQHSDA-CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTI 5964
            +Y+ ELE   +Y  F+    +F+L RGK  ++DD    ++R  G FKG++C+Y V   +++ ++  +D         +FG                      F   P++  ++ +VRVYVV+  +LHPADINGKADPY+++++G  +I+D+ENYI K LNP+FG+ F++E TFP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY  HGY  W+D   PT IL  LC++  I  P Y                        G + ++ E LAL VL +WEDI P   CKLV EH+ETRPL   +KPGIEQG +EMWVDMFP     P P IDISPRKP  YELR++I  T+ V L D ++FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRF+F FDYL AE+ IV  K ++++  DE EYK P  L +QV D+D   +D  +G ++  L++FP+ AK  K C       D      ++FK K+V+GWWP V         E + +E+ G VE E+ L+  EEAE  PAGLGR EP PLEKPNRP+ S    L+P   +
Sbjct: 1028 VYNKELET--EYDNFEDWLHTFNLLRGKIGDDDDTVSEEERIVGRFKGSMCVYKVPLPEDVTKEAGYD--------PNFG---------------------MFQGIPNNDPMNVLVRVYVVRATDLHPADINGKADPYVVIKLGKTDIKDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGISKTYAIHGYNLWRDPVKPTQILSKLCKEGKIDGPHYGP----------------------GQKKQTDEHLALSVLQHWEDI-PRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDMPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFLFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIEMAEPDVDLPMVSIFKQKRVKGWWPFV------ARNENDEMELTGKVEAELHLLSAEEAEKTPAGLGRNEPDPLEKPNRPNPSLAWMLSPLRVV 1551          

Query:  592 NYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSN-----------NVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTE-----------------------PKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQ--VNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIE-IDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEK---LRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDL 3627
            ++SE  ++P   +  P    P+       Q+S+T+ EAR L G N++P+  V  G +K+ T +K  TN P+YNE       +S       +I  K L +           G ++G F +D  TVY+   H F++KWA+L DP   T+G KG++K D++V+  GD  K P+K ++ ++ +IE N+L+P  +   +R      V +Y+AE LP MNT IM+N+K+A++G+ K L DPYV+V+FAG  G T V   SY P WN+QIIFTE FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT+GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLL+++      T+ P+ +    V +    PV+               GK E + LF +  E+T+I ++IG K  P+ FE++IG  G   D  S    ++       V   TE                              D  YFH+P+  KKPC Y+ +  +D R RL+  NI+DK+  +L     Q     L      V  +  + +       + D    A +   GT  KT+     +  ++   +K+K+                 +++    ++FL D   +PQH +PD+F++M+ +N R+AY RI ++D+++S +  E G+ CG V  V+LK      LP K       + +QA++++Y+WLGL K  R +  GLP GF      K       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DNI        ++  PP +V+EI+D D+    +F+GR F +P V +  + Y   +    L+++ +YRG   AGD+L +F+L++ I P  K       P +E              G  D E+   L +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I+++  +PNF+  +    + LP N    PP++I  ++   FG   +VG+H ++ L
Sbjct:   10 HFSEPQVIPPSLYLFPFIPTPVPSVPSLPQVSITVIEARQLVGLNMDPVVCVEVGDEKKYTSMKESTNCPYYNE-------VSATVPTSPVIHSKNLLRS----------GTLVGSFKLDVGTVYTQPEHQFYHKWALLSDPDDITAGLKGYLKCDIAVVGKGDNIKTPHKANETDEDDIEGNLLLPDGV-PAERQWARFYVKIYRAEGLPRMNTSIMANVKKALIGENKDLVDPYVQVAFAGQKGKTSVQKSSYEPMWNEQIIFTEMFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKIANEGDK---GFLPTFGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLLSLAVEILDTTNPELTSSTEVQIEGAQPVAEVRTTLSYHLHLTCTGKMEEFFLFGAFLESTMIDRKIGDK--PINFEVTIGNYGNQIDGISKPSMRKRKEGGDGVEEETELLQNSSDDEADEDGEMLSISSSPAMKPLITDRNYFHLPFFDKKPCTYIKSWWQDQRRRLYNANIMDKIADKLVNETGQGEAEVLHEGAGNVFVLEGLGRLTGDGLTNHD--CFAQQENMGTQAKTMRSQVKKNTVK---DKLKL-----------------VQNFLQKLRFLAD---EPQHSIPDIFIWMMSNNKRIAYARIPSKDILYSIVDEETGKDCGKVKCVFLK------LPGKRGFGPAGWTVQAKMEVYMWLGLSKQRRDFLCGLPCGFEEIKAVKGPGLQSFPPISLSYTKKQVFQLRAHMYQARSLFAADSSGLSDPFARVFFNTQSQCTEVLNETLCPTWDQLLVFDNIELYGEAHEMRDDPPIIVIEIYDQDTVGKADFMGRTFAKPVVKMSDERYCPPRFPPQLEYYQIYRGNSTAGDLLGAFELLQVIGPAGKS----DLPQIE--------------GPTDIERGPILPVPLGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGRGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSL 989          

Query: 4210 SDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCD-PFQHSDA-CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTI 5964
            +   W     +Y+ ELE   +Y  F+    +F+L RGK  ++DD    ++R  G FKG++C+Y V   +++ ++  +D         +FG                      F   P++  ++ +VRVYVV+  +LHPADINGKADPY+++++G  +I+D+ENYI K LNP+FG+ F++E TFP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY  HGY  W+D   PT IL  LC++  I  P Y      V++  + F          G + ++ E LAL VL +WEDI P   CKLV EH+ETRPL   +KPGIEQG +EMWVDMFP     P P IDISPRKP  YELR++I  T+ V L D ++FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRF+F FDYL AE+ IV  K ++++  DE EYK P  L +QV D+D   +D  +G ++  L++FP+ AK  K C       D      ++FK K+V+GWWP V         E + +E+ G VE E+ L+  EEAE  PAGLGR EP PLEKPNRP+ S    L+P   +
Sbjct: 1000 NSQQWTTAGIVYNKELET--EYDNFEDWLHTFNLLRGKIGDDDDTVSEEERIVGRFKGSMCVYKVPLPEDVTKEAGYD--------PNFG---------------------MFQGIPNNDPMNVLVRVYVVRATDLHPADINGKADPYVVIKLGKTDIKDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGISKTYAIHGYNLWRDPVKPTQILSKLCKEGKIDGPHYGP-GGRVKVTNRVFT---------GQKKQTDEHLALSVLQHWEDI-PRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDMPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFLFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIEMAEPDVDLPMVSIFKQKRVKGWWPFV------ARNENDEMELTGKVEAELHLLSAEEAEKTPAGLGRNEPDPLEKPNRPNPSLAWMLSPLRVV 1545          

Query:  676 FQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNK-TDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAI----------------------------------------------KTTSQPDSI-KIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQ----------------------YVHSLTEPKYAYTFDNQYFH-IPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAK---KTLLDVKYQKLIRMGLEKMKMSWSVTIEC---LSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKT--NYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKM------PPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSD-GVSNKAFDNKDEK---------------GPEKTKAGVKSDAKPDVTNPVPGE------PEKLIRFVPKEEMESA-DWWTRYYATLGDLDDPNLYKPEDEI 3963
             QI++TI EAR L G+NI+P+  +  G  K+ T +K  TN PFYNEYF FDF   + +L ++IIR+  +  K       +    +IG F +D  TVY+   H F  KWA+L DP    +G KG++K D+SV   GD  +   K +D EE   IE N+LIP+    ++R      V +Y+AE LP MN+ IM+N+ +A +GD K L DPYV V FAG  G T        P W++QI+F E FPP   R++I V D   + D  ++T FIDL KI +  + ++ GFLPT+GP+WINLYG+PR  +   +++  Q  N+   EGV+FRGR+LI I                                              K TS  D    I V+V   +        K E +LLF SIFEATLI ++IG K   ++FE S+G  G   D  SH   K+++ E +                      ++   T  K   T  N+ +H +P+  +KPC+Y+ +   D   RL+  N+L K+   L + + QV  L     K+  +   +K  +     I++  + I +    +K    T LD K   L R  LE M  +    ++    +S+  +   ++ L   +KFL D   +PQH +PDVF++++ +N RVAY RI ARD+++S +  E+G  CG + T++ K      LP K    +N+QA++ +YLWLG  K        LP G+  +  ++        PP  + Y  +  FQLR ++Y  R LI +D SGLSDPF KV    H + + +  +T SP W++ ++ +N+V     K +   PP++V+E++D D+ +  E+IG     P+V +    Y+ +KL +  ++ G +  G++L +F+L+++ P S    V   P +E      AQ+              +P ++RP +  +R+E+L WGVR+L++++++S                V++P+++IE  G  +KS +I+ + ++PNFN       + LP N    PP+SI  +++  FG   +VG H I  L ++  +         ++  +  L AQ     + D G  +  + + D                  P  T A   + A    ++P   +       +K  R +  E  E+  DWW++YYA++  L      +P D I
Sbjct:   19 LQIAITITEARQLIGENIDPVVIIEIGDDKKQTTVKEGTNAPFYNEYFVFDFIGPQEQLFDKIIRLSVMHNK-------LLGSILIGSFRVDLGTVYNEPGHQFCDKWALLTDPSDIRTGVKGYLKCDISVAGKGDTVQSSQKISDAEE--QIEKNLLIPKGF-PSERPWARFYVRIYRAEGLPKMNSSIMANVTKAFIGDSKDLVDPYVVVMFAGQMGRTTAQKNCADPLWHEQIVFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISDEQDGDK-GFLPTFGPAWINLYGSPRNTT---LMEDHQELNEGHGEGVSFRGRILIEIAVEILSGGAHESKFSKAIKDMKLPLKDSKSSKGSGKEKGEKGSEDAKPTSAVDKTNSIQVEVEPFDVPPEFQEEKSEDFLLFGSIFEATLIDRKIGDKG--ISFECSVGNYGNVLDGVSHSGTKKKSPEHEDGEGAPLLQPEEGEAAPEVSLSFISVTTPEKPLITDGNRNYHYLPFYERKPCIYVKSTWGDQTFRLYSSNMLQKMADHLEDGLEQVKELV----KISDLAPEEKMRDVLTEFINQSRAFISTAEKRSKMTNTTALDKKRVTLCRQELEAMSANAKAIVQQKKKMSLSDMTREMQSLIDNIKFLVD---EPQHTVPDVFIWLLSNNKRVAYARIPARDILYSTLAEERGHHCGKIKTLFFK------LPGKRPPGWNVQAKVDVYLWLGSSKYSHFIFENLPGGYEVETHSASSGHHGSPPPGNLVYKSQHMFQLRAHMYQARGLIAADTSGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNNLVIYGELKDIAEDPPNIVIEVYDDDALSKSEYIGSTVASPTVILANQTYSPAKLTYHPLFCGNLSGGELLAAFELLQV-PESG---VQSLPPIET--PDAAQI------------YPVPSNIRPVLSKYRVEVLFWGVRELKKVQLLS----------------VDRPQVLIECAGKGVKSCVIQSYKSNPNFNVIGDWFEVELPENEVLHPPLSICVVDWRAFGRSTLVGTHTINCLKQFLYKPH-----REQTSAIVGLVAQSPPYDSPDPGEQDHIYVDIDPSLRKDMPQSRPHSPAPSPTATLAPSPTPAAGPASDPAASKGSLRRSTKKKKRTIADESAENVIDWWSKYYASVEKLQKVISLEPTDII 1154          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQD-RFAGVFKGNICIY-NVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAED-SIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDAC--AKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +  ++IYS ELEN  ++  F+   R+F L RGK    DD + + D R  G FKG+  IY NV  D+ + KD              G Q               L++ + +   H+V  ++RVY+V G NL PAD +GK+DPYI++R+G  EI+DR+NYIPK LNP+FGR FEM+ TFP++S L + +YD D +  DDLIGET IDLENR+ S HR TCGL S Y   GY  W+DS  PT IL  LC+ N +  P        ++I GK F   ++   DD  Q++S E LAL  LH+W DI P+  C LV EHIETRPLY ++KPGIEQG ++MWVDMFP+   +P PP+DISPRKP  YELRI+I  TE+V L D N FT +KS DIY+K W+K  + D Q+TD H+ SL+G+G FNWRFVF F YL AE   +V K +NI+ +++ E K P  L +QV D D L SD  +G ++  L+ F + AK  K CD    +      K ++F+ K++RGWWP V +            E+ G VE E  LV  EEAE NP G  R+EP PLEKPNRP+ SF  F+NP+  + + I
Sbjct: 1174 LATLQIYSNELEN--EFKNFEDWVRTFELLRGKST--DDEHSVHDDRIIGKFKGSFSIYKNV--DDTNPKD--------------GGQ---------------LRILQGIPPNHTVKVLIRVYIVAGFNLSPADPDGKSDPYIVLRLGKTEIKDRDNYIPKQLNPVFGRSFEMQATFPKDSILSIVIYDHDMIGTDDLIGETKIDLENRFFSRHRATCGLQSQYEIEGYNAWRDSTKPTEILAKLCKDNKLDGPYLRP--GQIQIGGKIFTGQTIFNQDD-EQVESYEHLALKALHSWSDI-PDIGCNLVPEHIETRPLYHKDKPGIEQGRIQMWVDMFPTDLPLPGPPVDISPRKPKGYELRIIIWNTEDVILEDENIFTGQKSSDIYVKGWLKGIEDDSQETDVHYNSLTGEGNFNWRFVFPFSYLPAEKLMVVSKRENIFSLEKTERKIPTVLLLQVWDFDRLSSDDFLGSMELNLNAFHRGAKTAKGCDLSMAATPKDENKISIFQQKRIRGWWPFVKSG-----------ELTGKVEAEFHLVTTEEAEKNPVGRARKEPEPLEKPNRPNTSFNWFVNPFKCLYHLI 1715          

Query:  676 FQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAI----------------------------------------------KTTSQPD---SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFEL-SIGTTGICPDEYSHLPKKEENFESQ----------------------YVHSLTEPKYAYTFDNQYFH-IPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKT--NYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKM------PPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESA-DWWTRYYATLGDLDDPNLYKPEDEI 3963
             QI++TI EAR L G+NI+P+  +  G  K+ T +K  TN PFYNEYF FDF   + +L ++IIR+  +  K       +    +IG F +D  TVY+   H F  KWA+L DP    +G KG++K D+SV   GD  +   K    E+  IE N+LIP+    ++R      V +Y+AE LP MN+ IM+N+ +A +GD K L DPYV V FAG  G T        P W++QI+F E FPP   R++I V D   + D  ++T FIDL KI +  + ++ GFLPT+GP+WINLYG+PR  +   +++  Q  N+   EGV+FRGR+LI I                                              K TS  D   SI++ V+     P  +    K E +LLF SIFEATLI ++IG K   ++FE+ S G  G   D  SH   K+++ E +                      ++   T  K   T  N+ +H +P+  +KPC+Y+ +   D   RL+  N+L K+   L + + QV  L     K+  +   +K  +     I++  + I +    +K T      +K + +              C     +     +L+ F       +  PQH +PDVF++++ +N RVAY RI ARD+++S +  E+G  CG + T++ K      LP K    +N+QA++ +YLWLG  K        LP G+  +  ++        PP  + Y  +  FQLR ++Y  R LI +D SGLSDPF KV    H + + +  +T SP W++ ++ +N+V     K +   PP++V+E++D D+ +  E+IG     P+V +    Y+ +KL +  ++ G +  G++L +F+L++         V   P +E      AQ+              +P ++RP +  +R+E+L WGVR+L++++++S                V++P+++IE  G  +KS +I+ + ++PNFN       + LP N    PP+SI  +++  FG   +VG H I  L ++  +            H +  +A   + A S     ++  +     P  T A V+   +           +K  R +  E  E+  DWW++YYA++  L      +P D I
Sbjct:   39 LQIAITITEARQLIGENIDPVVIIEIGDDKKQTTVKEGTNAPFYNEYFVFDFIGPQEQLFDKIIRLSVMHNK-------LLGSILIGSFRVDLGTVYNEPGHQFCDKWALLTDPSDIRTGVKGYLKCDISVAGKGDTVQSSQKISDAEE-QIEKNLLIPKGF-PSERPWARFYVRIYRAEGLPKMNSSIMANVTKAFIGDSKDLVDPYVVVMFAGQMGRTTAQKNCADPLWHEQIVFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISDEQDGDK-GFLPTFGPAWINLYGSPRNTT---LMEDHQELNEGHGEGVSFRGRILIEIAVEILSGGAHESKFSKAIKDMKLPLKDSKSSKGSGKEKGEKGSEDAKPTSAVDKTNSIQVEVEPFDVPPEVSFSVEKSEDFLLFGSIFEATLIDRKIGDKG--ISFEIISTGNYGNVLDGVSHSGTKKKSPEHEDGEGAPLLQPEEGEAAPEVSLSFISVTTPEKPLITDGNRNYHYLPFYERKPCIYVKSTWGDQTFRLYSSNMLQKMADHLEDGLEQVKELV----KISDLAPEEKMRDVLTEFINQSRAFISTAEKRSKMTNTTALDKKRVTL--------------CRQELVVGPKRYNLSHF-------LAQPQHTVPDVFIWLLSNNKRVAYARIPARDILYSTLAEERGHHCGKIKTLFFK------LPGKRPPGWNVQAKVDVYLWLGSSKYSHFIFENLPGGYEVETHSASSGHHGSPPPGNLVYKSQHMFQLRAHMYQARGLIAADTSGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNNLVIYGELKDIAEDPPNIVIEVYDDDALSKSEYIGSTVASPTVILANQTYSPAKLTYHPLFCGNLSGGELLAAFELLQSG-------VQSLPPIET--PDAAQI------------YPVPSNIRPVLSKYRVEVLFWGVRELKKVQLLS----------------VDRPQVLIECAGKGVKSCVIQSYKSNPNFNVIGDWFEVELPENEVLHPPLSICVVDWRAFGRSTLVGTHTINCLKQFLYK-----------PHREQTSAIVGLVAQSPKDMPQSRPHSPAPSPTATLALVRGSLRRST--------KKKKRTIADESAENVIDWWSKYYASVEKLQKVISLEPTDII 1114          

Query: 4237 KIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQD-RFAGVFKGNICIY-NVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAED-SIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDAC--AKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            KIYS ELEN  ++  F+   R+F L RGK    DD + + D R  G FKG+  IY NV  D+ + KD              G Q               L++ + +   H+V  ++RVY+V G NL PAD +GK+DPYI++R+G  EI+DR+NYIPK LNP+FGR FEM+ TFP++S L + +YD D +  DDLIGET IDLENR+ S HR TCGL S Y   GY  W+DS  PT IL  LC+ N +  P        ++I GK F   ++   DD  Q++S E LAL  LH+W DI P+  C LV EHIETRPLY ++KPGIEQG ++MWVDMFP+   +P PP+DISPRKP  YELRI+I  TE+V L D N FT +KS DIY+K W+K  + D Q+TD H+ SL+G+G FNWRFVF F YL AE   +V K +NI+ +++ E K P  L +QV D D L SD  +G ++  L+ F + AK  K CD    +      K ++F+ K++RGWWP V +            E+ G VE E  LV  EEAE NP G  R+EP PLEKPNRP+ SF  F+NP+  + + I
Sbjct: 1137 KIYSNELEN--EFKNFEDWVRTFELLRGKST--DDEHSVHDDRIIGKFKGSFSIYKNV--DDTNPKD--------------GGQ---------------LRILQGIPPNHTVKVLIRVYIVAGFNLSPADPDGKSDPYIVLRLGKTEIKDRDNYIPKQLNPVFGRSFEMQATFPKDSILSIVIYDHDMIGTDDLIGETKIDLENRFFSRHRATCGLQSQYEIEGYNAWRDSTKPTEILAKLCKDNKLDGPYLRP--GQIQIGGKIFTGQTIFNQDD-EQVESYEHLALKALHSWSDI-PDIGCNLVPEHIETRPLYHKDKPGIEQGRIQMWVDMFPTDLPLPGPPVDISPRKPKGYELRIIIWNTEDVILEDENIFTGQKSSDIYVKGWLKGIEDDSQETDVHYNSLTGEGNFNWRFVFPFSYLPAEKLMVVSKRENIFSLEKTERKIPTVLLLQVWDFDRLSSDDFLGSMELNLNAFHRGAKTAKGCDLSMAATPKDENKISIFQQKRIRGWWPFVKSG-----------ELTGKVEAEFHLVTTEEAEKNPVGRARKEPEPLEKPNRPNTSFNWFVNPFKCLYHLI 1674          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKT-KPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSP---------------------------------------VSGNENLGKSDFNV-PSYNLTKLERHEGHIRLPSDTSSVE-SDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPK---HIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH----LPKKEENFESQY------------------VHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            M+LIV L++++ ++   +   KV FR   F +   +  +   +    F WP+A  +D+ + L I+    ++   +KL G   +VL  ++ +  + + +T +D+   I   +L+ E+ Y +                                        +SG ++  ++  +V  +  L K   H+   +   + + +E  D D+   +  D +D       S  +L      K  K    ++P + +  D+Q+S+T+ EAR L G N++P+  V  G  K+ T +K  TN P+YNEYF FDF +S   + ++II+I  +  K+ + +     G ++G F +D  TVYS   H F +KWA+L DP   ++G KG+VK D++V+  GD  K P+K ++ ++ +IE N+L+P+ +   +R      V +Y+AE LP MNT +M+N+K+A +G+ K L DPYV+V FAG  G T V   SY P WN+Q++FT+ FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RL++ +      TS P+ +    V V    PVS +  G+ E + LF +  EA++I ++ G   KP+TFE++IG  G   D  S      P+KE   E +                     S T P      D  YFH+PY  +KPC+Y+ +   D R RL+  NI+D +  +L E +  V  +  + +K    R ++  +E       + LS     +G + +T LD +  K     LE M          +   T+   ++   +F++ L     +PQH +PDVF++M+ +N R+AY R+ ++DL+ S +  E G+ C  V T++LK      LP K       + +QA+L++YLWLGL K  + +  GLP GF      +       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DN+        ++  PP +V+EI+D DS    +F+GR F +P V +  + Y   +    L+++ +YRG+  AGD+L +F+L++I P  K       P +   ++M        +G      + +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNFN  +    + LP N    PP++I  ++   FG   +VG+H ++ L  +
Sbjct:    1 MALIVHLKTVSELRGKGDRIAKVTFRGQSFYSRVLENCEGVADFDETFRWPVASSIDRNEVLEIQIFNYSKVFSNKLIGTFCMVLQKVVEENRVEVTDTLMDDSNAIIKTSLSMEVRYQATDGTVGPWDDGDFLGDESLQEEKDSQETDGLLPGSRPSTRISGEKSFRRAGRSVFSAMKLGKTRSHKEEPQRQDEPAVLEMEDLDHLAIQLGDGLDPDSVSLASVTALTSNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRS-----GTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGV-PPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDK---GFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRKNGD--KPITFEVTIGNYGNEVDGMSRPLRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLASVSSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMI-KTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGRSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRSCQNFLQKLRFLADEPQHSIPDVFIWMMSNNKRIAYARVPSKDLLFSIVEEELGKDCAKVKTLFLK------LPGKRGFGSAGWTVQAKLELYLWLGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGSATAGDLLAAFELLQIGPSGK----ADLPPINGPVDM-------DRG----PIMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF 1228          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDA--CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            I+ +K+Y  ELE+  ++  F+    +F+L RGK  +++DG   ++R  G FKG++C+Y V   +++  +  +D         ++G                      F   P +  ++ +VR+YVV+  +LHPADINGKADPYI +++G  +IRD+ENYI K LNP+FG+ F++E +FP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY+ HGY  W+D   P+ IL  LC++  +  P +   +  V +  + F   S IED++G +  + E +AL  L +WEDI P   C+LV EH+ETRPL   +KPGIEQG LE+WVDMFP     P  P+DISPRKP  YELR+++  T+ V L D +FFT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWR++F FDYL AE+ IV  K ++++  DE EYK P  L +Q+ D+D   +D  +G ++  L++FP+ AK  K C     +        ++FK K+V+GWWPL+         E +  E+ G VE E+ L+  EEAE NP GL R EP PLEKPNRPD SF+ FLNP  + +YF+
Sbjct: 1405 IDELKVYPKELES--EFDSFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYD--------PTYG---------------------MFQGIPSNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNIWRDPMKPSQILTRLCKEGKVDGPHFGP-HGRVRVANRVFTGPSEIEDENGQRKPTDEHVALSALRHWEDI-PRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLL------ARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFL 1958          

Query:  646 IDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH----LPKKEENFESQY------------------VHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            ++P + +  D+Q+S+T+ EAR L G N++P+  V  G  K+ T +K  TN P+YNEYF FDF +S   + ++II+I  +  K+ + +     G ++G F +D  TVYS   H F +KWA+L DP   ++G KG+VK D++V+  GD  K P+K ++ ++ +IE N+L+P+ +   +R      V +Y+AE LP MNT +M+N+K+A +G+ K L DPYV+V FAG  G T V   SY P WN+Q++FT+ FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RL++ +      TS P+ +    V V    PVS +  G+ E + LF +  EA++I ++ G   KP+TFE++IG  G   D  S      P+KE   E +                     S T P      D  YFH+PY  +KPC+Y+ +   D R RL+  NI+D +  +L E +  V  +  + +K    R ++  +E       + LS     +G + +T LD +  K     LE M          +   T+   ++   +F++ L     +PQH +PDVF++M+ +N R+AY R+ ++DL+ S +  E G+ C  V T++LK      LP K       + +QA+L++YLWLGL K  + +  GLP GF      +       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DN+        ++  PP +V+EI+D DS    +F+GR F +P V +  + Y   +    L+++ +YRG+  AGD+L +F+L++I P  K       P +   ++M        +G      + +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNFN  +    + LP N    PP++I  ++   FG   +VG+H ++ L  +
Sbjct:  258 MEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRS-----GTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGV-PPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDK---GFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRKNGD--KPITFEVTIGNYGNEVDGMSRPLRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLASVSSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMI-KTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGRSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRSCQNFLQKLRFLADEPQHSIPDVFIWMMSNNKRIAYARVPSKDLLFSIVEEELGKDCAKVKTLFLK------LPGKRGFGSAGWTVQAKLELYLWLGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGSATAGDLLAAFELLQIGPSGK----ADLPPINGPVDM-------DRG----PIMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF 1243          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDA--CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYR 5985
            I+ +K+Y  ELE+  ++  F+    +F+L RGK  +++DG   ++R  G FKG++C+Y V   +++  +  +D         ++G                      F   P +  ++ +VR+YVV+  +LHPADINGKADPYI +++G  +IRD+ENYI K LNP+FG+ F++E +FP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY+ HGY  W+D   P+ IL  LC++  +  P +   +  V +  + F   S IED++G +  + E +AL  L +WEDI P   C+LV EH+ETRPL   +KPGIEQG LE+WVDMFP     P  P+DISPRKP  YELR+++  T+ V L D +FFT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWR++F FDYL AE+ IV  K ++++  DE EYK P  L +Q+ D+D   +D  +G ++  L++FP+ AK  K C     +        ++FK K+V+GWWPL+         E +  E+ G VE E+ L+  EEAE NP GL R EP PLEKPNRPD +F+ FLNP  +IKY I  R
Sbjct: 1400 IDELKVYPKELES--EFDSFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYD--------PTYG---------------------MFQGIPSNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNIWRDPMKPSQILTRLCKEGKVDGPHFGP-HGRVRVANRVFTGPSEIEDENGQRKPTDEHVALSALRHWEDI-PRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLL------ARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTR 1956          

Query:  619 ERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPK-RPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAI--------------------------------------------------KTTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFE---------------------SQYVHSLTEPKYAYTFDNQ--YFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMK-MSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKT--NYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKD----CFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVP-GFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESD 3681
            +R  KL   I    +K +++QI+VTI EAR L G+NI+P+  +  G  K+ + +K  TN+PFYNEYF FDF   ++ L ++II+I  L  K       +    +IG F +D  TVY+   H F  KWA+L DP    +G KG++K D+SV   GD  K  P  +D EE   IE N+LIPQ    ++R      V +Y+AE LP MN+ IM+N+ +A +GD K L DP+VEVSFAG TG T V      P W++Q++F E FPP   R++I V D   + D  ++T FIDL KI N  + ++ GFLPT+GP+WINLYG+PR +S   ++   Q  N+   EGV+FRGR+L+ I                                                  +TT + +S ++ V+  +  P    +  K E +LLF + FEAT+I ++IG K  P++FE+S+G  G   D  SH   K+++ E                     +  + S T P+     D    Y ++P+ +KKPC+  I+   D   RL   N+L+K+   L E + +V  L    ++    + +K ++  F       +S  +    T  +T LD K   L    L+ M   +  V  +     ++D  I++  +FV+ +   + +PQH +PDVF++M+ +N RVAY RI A+DL++S I  + G+ CG + T +LK      LP K    + +QA++ IYLWLG  +        LP G+  +       +  PP  + Y  +  FQLR ++Y  R LI +D +GLSDPF KV      + + +  +T SP W++ ++ + +V +   K +   PP VV+E++D D+    E++G     P V +   +Y   KL +  ++ G +  GD+L  F+L+++ P   +   P G P +  +                     +P ++RP +  +R+E+L WGVR++++++++S                V++P+++IE GG  +KS +I+ +  +PNF+    +  + LP N    PP+SI  +++  FG   +VG + I  L ++  + +    L  ++D
Sbjct:   63 KRRAKLLTKIHDGEIKSQNYQITVTITEARQLVGENIDPVVTIEIGDDKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVLHHK-------LIGSILIGSFRVDVGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDILKTNPKTSDAEE--QIEKNLLIPQGF-PSERPWARFYVRLYRAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTSVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDK-GFLPTFGPAWINLYGSPRNHS---LMDDYQELNEGFGEGVSFRGRILVEIAVEILSGGAQESKFSKALKELKLSSKDKDSKSSKGSSKDKADKADDSKAQQTTDKTNSTEVEVESFAVPP--EIIPEKYEDFLLFGAFFEATMIDRKIGDK--PISFEVSVGNFGNLIDGGSHHGSKKKSTELTEEDVLPLLHEGEKDVAQDSAISMASTTHPEKPLVTDGNRNYNYLPFGAKKPCVSFISSWGDQTFRLHWSNMLEKMADLLEEGIEEVRELVKVSQEAPEEK-MKTALRDFITQSRVFISEAEKKPKTLNQTALDKKRLTLCWQELKAMADEAEGVIRQQKKKLSLDEMIREAQNFVEKIHFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPIEEQMGKHCGKIKTHFLK------LPGKRPPGWTVQAKVDIYLWLGSTRYSNTILDNLPVGYEAEMPPKSSGTHHPPSALLYQAQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSQCQTTKIISQTLSPTWNQMLLFNELVLHGEEKELLESPPHVVVELYDSDAVGKPEYLGATVAAPVVTLADQDYEPPKLSYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPTGPPDITQIYP-------------------VPSNIRPVLSKYRVEVLFWGVREMKKVQLLS----------------VDRPQVLIECGGGGVKSCVIQSYKNNPNFSVQAEAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINCLKQFLCKPRETFALTSQTD 1105          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQ-IKSLEPLALVVLHNWEDIVPEC--KLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGT-AIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCD--PFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIV 6087
            +  +KIY  +LE+  ++  F+   ++F L+RGK  EED G +  DR  G FKG+ CIY   ED+  E        D  +L                      ++ + +   H V  ++RVY+V   NL PAD +GK+DPYI++R+G  EI+DR+ YIPK LNP+FGR FE++ TFP+ES L V +YD D +  DDLIGET IDLENR+ S HR  CGL S Y   GY  W+D+  PT IL  LC+ N +  P +      ++I  K F+  ++  ++D  + ++S E LAL VLH+WEDI PE   +LV EHIETRPLY ++KPG+EQG L+MWVDMFP  T  + PP+DISPRKP  YELR+ I  TE+V L D N FT +KS DIY+K W+K  + D Q+TD H+ SL+G+G FNWRF+F F YL AE  +V  K +NI+ +++ E KTP  L +QV D + L SD  +G L+  L+ FP+ AK  K+CD   F+++    K ++F+ K+VRGWWP   +            E+ G VE E  LV  EEAE NP G  R+EP PL KPNRPD SF  F++P+  + + I    K  +I   I++I ++ +VLFIY  PG  SR IV
Sbjct: 1278 LAALKIYDGDLES--EFNNFEDWVKTFELFRGKSTEEDHGLD-GDRVIGKFKGSFCIYKSPEDSTSE--------DSGQL----------------------RIQQGIPPNHPVQVLIRVYIVAAFNLSPADPDGKSDPYIVLRLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDMIGSDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYF--RPGKIQIGKKVFSGKTVFNEEDSEEMVESYEHLALKVLHSWEDI-PEAGWRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDTPQLGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWIKGLEDDRQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLSKFENAVQENKISIFQQKRVRGWWPFAKSK-----------ELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFVSPFKCLYHLIWKNYKKYIIIAFILIILIVFLVLFIYTLPGAISRRIV 1858          

Query:  619 ERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPK-RPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAI--------------------------------------------------KTTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFE---------------------SQYVHSLTEPKYAYTFDNQ--YFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMK-MSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKT--NYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKD----CFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVP-GFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESD 3681
            +R  KL   I    +K +++QI+VTI EAR L G+NI+P+  +  G  K+ + +K  TN+PFYNEYF FDF   ++ L ++II+I  L  K       +    +IG F +D  TVY+   H F  KWA+L DP    +G KG++K D+SV   GD  K  P  +D EE   IE N+LIPQ    ++R      V +Y+AE LP MN+ IM+N+ +A +GD K L DP+VEVSFAG TG T V      P W++Q++F E FPP   R++I V D   + D  ++T FIDL KI N  + ++ GFLPT+GP+WINLYG+PR +S   ++   Q  N+   EGV+FRGR+L+ I                                                  +TT + +S ++ V+  +  P    +  K E +LLF + FEAT+I ++IG K  P++FE+S+G  G   D  SH   K+++ E                     +  + S T P+     D    Y ++P+ +KKPC+  I+   D   RL   N+L+K+   L E + +V  L    ++    + +K ++  F       +S  +    T  +T LD K   L    L+ M   +  V  +     ++D  I++  +FV+ +   + +PQH +PDVF++M+ +N RVAY RI A+DL++S I  + G+ CG + T +LK      LP K    + +QA++ IYLWLG  +        LP G+  +       +  PP  + Y  +  FQLR ++Y  R LI +D +GLSDPF KV      + + +  +T SP W++ ++ + +V +   K +   PP VV+E++D D+    E++G     P V +   +Y   KL +  ++ G +  GD+L  F+L+++ P   +   P G P +  +                     +P ++RP +  +R+E+L WGVR++++++++S                V++P+++IE GG  +KS +I+ +  +PNF+    +  + LP N    PP+SI  +++  FG   +VG + I  L ++  + +    L  ++D
Sbjct:   63 KRRAKLLTKIHDGEIKSQNYQITVTITEARQLVGENIDPVVTIEIGDDKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVLHHK-------LIGSILIGSFRVDVGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDILKTNPKTSDAEE--QIEKNLLIPQGF-PSERPWARFYVRLYRAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTSVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDK-GFLPTFGPAWINLYGSPRNHS---LMDDYQELNEGFGEGVSFRGRILVEIAVEILSGGAQESKFSKALKELKLSSKDKDSKSSKGSSKDKADKADDSKAQQTTDKTNSTEVEVESFAVPP--EIIPEKYEDFLLFGAFFEATMIDRKIGDK--PISFEVSVGNFGNLIDGGSHHGSKKKSTELTEEDVLPLLHEGEKDVAQDSAISMASTTHPEKPLVTDGNRNYNYLPFGAKKPCVSFISSWGDQTFRLHWSNMLEKMADLLEEGIEEVRELVKVSQEAPEEK-MKTALRDFITQSRVFISEAEKKPKTLNQTALDKKRLTLCWQELKAMADEAEGVIRQQKKKLSLDEMIREAQNFVEKIHFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPIEEQMGKHCGKIKTHFLK------LPGKRPPGWTVQAKVDIYLWLGSTRYSNTILDNLPVGYEAEMPPKSSGTHHPPSALLYQAQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSQCQTTKIISQTLSPTWNQMLLFNELVLHGEEKELLESPPHVVVELYDSDAVGKPEYLGATVAAPVVTLADQDYEPPKLSYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPTGPPDITQIYP-------------------VPSNIRPVLSKYRVEVLFWGVREMKKVQLLS----------------VDRPQVLIECGGGGVKSCVIQSYKNNPNFSVQAEAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINCLKQFLCKPRETFALTSQTD 1105          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQ-IKSLEPLALVVLHNWEDIVPEC--KLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGT-AIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCD--PFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIV 6087
            +  +KIY  +LE+  ++  F+   ++F L+RGK  EED G +  DR  G FKG+ CIY   ED+  E        D  +L                      ++ + +   H V  ++RVY+V   NL PAD +GK+DPYI++R+G  EI+DR+ YIPK LNP+FGR FE++ TFP+ES L V +YD D +  DDLIGET IDLENR+ S HR  CGL S Y   GY  W+D+  PT IL  LC+ N +  P +      ++I  K F+  ++  ++D  + ++S E LAL VLH+WEDI PE   +LV EHIETRPLY ++KPG+EQG L+MWVDMFP  T  + PP+DISPRKP  YELR+ I  TE+V L D N FT +KS DIY+K W+K  + D Q+TD H+ SL+G+G FNWRF+F F YL AE  +V  K +NI+ +++ E KTP  L +QV D + L SD  +G L+  L+ FP+ AK  K+CD   F+++    K ++F+ K+VRGWWP   +            E+ G VE E  LV  EEAE NP G  R+EP PL KPNRPD SF  F++P+  + + I    K  +I   I++I ++ +VLFIY  PG  SR IV
Sbjct: 1278 LAALKIYDGDLES--EFNNFEDWVKTFELFRGKSTEEDHGLD-GDRVIGKFKGSFCIYKSPEDSTSE--------DSGQL----------------------RIQQGIPPNHPVQVLIRVYIVAAFNLSPADPDGKSDPYIVLRLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDMIGSDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYF--RPGKIQIGKKVFSGKTVFNEEDSEEMVESYEHLALKVLHSWEDI-PEAGWRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDTPQLGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWIKGLEDDRQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLSKFENAVQENKISIFQQKRVRGWWPFAKSK-----------ELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFVSPFKCLYHLIWKNYKKYIIIAFILIILIVFLVLFIYTLPGAISRRIV 1858          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFN----------VPSYNLTKLERHEGHI---------RLPSDTSSVESDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSL-KIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKS--HIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAI--------------KTTS----------------------------QPDSIKIG-----------VDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQY--VHSLTE-----------------PKYAYTFDNQ--YFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTL-----LDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAI---KDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLY------------KMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVED----KINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATL 3918
            M+L V ++ LTG+    +  +++ FR    +T         ++G  F WP        +SL ++ +  +R    +  G + I L  L     + L E  VDE++R++ I +  +++Y  P        + DF           +P+     +E  E  +         RL     + + + +  + EP  + +     +    S L  R   LP+  DP  + K +DFQ+ VT+ EA+ L G NINP   V  G Q++ T     TN PFYNEYF F+F  +RL L + ++ I A   ++   + TR       IG F +D           F  KWA L DP+   +G KG+VK+ LSV   GD P  P         +IE N+L+P  + Q +R    + V VY+AE LP + T ++ ++ +A L D   L DPYV VSF G  G T V     +P WN+Q+ F E FPP    LR+ +RD+  + D  ++T  +DL +I NS      GF PT+GP+W+ LYG+        +    Q  N+ L EG+ FRGRLL+A+              +TT                             QP S               V+V    P+  N     E +LLF  +FEAT+I   + KK  P++ E+SIG  G   ++     + +E  ES    V  L E                  ++    D    Y  +P R +KPCL++ +  ED+  RL   N + K+ + L   +++V  +  R       R +K+++E        V  + + C G  ++T+     LD    KL+   L  M       +  L +  +   +   K L + ++FL     +PQ  LPDV ++M     RVAY RI A+D+++S +  E+G+ CG + ++ L       +P      + A+L+++LWLGL K  +                GLP+  ++D F                FQLR +LY  R ++ +DDSGLSDPF +V+I    + + V  +T SP+WDE ++ D ++ +   + ++  PP VV+ +FD +      F+GR F  P V +  D Y   +LQ++ + +G   AG+++ +F+LIE+D +S  +  P  PS     ++ + V   S        L +P  VRP +  FR+E+L WG+R L R+                 +F + +P++++E+ G R++S+++ ++  +PNF + +  V + LP      PP+SI  I    FG   +VG+H++  ++ + ++     +  E+ + E+  L     Q +      G S +       K P K          P++   +P +PE++            DWW++YYA+L
Sbjct:    1 MALTVCVRHLTGLPGTHDRQVRLCFRGFTQKTRKIHCGREADVGELFRWPHYGSPLAGESLSVQVVNCSRVFSPRPLGTLVISLQQLQSAGHLVLREALVDERLRVSPIQVELDLKYQPPEGAAGTWAEEDFGTPIRDSLELIIPNVGFQDMEPGEAQLERRAVALGRRLARSLGTQDDEENELELEPELEEEPDVEISGVVFSPLKSRALGLPRG-DPFKVCKAQDFQVGVTVLEAQKLVGVNINPYVAVRVGDQRKVTATLRGTNCPFYNEYFLFEFHETRLHLQDLLLEITAFHSQTLPFMATR-------IGTFRMDLGMALDQPDGHFHQKWAPLHDPRDTRAGTKGFVKITLSVRARGDLPLPPPPPCPGTSSDIEKNLLLPHGV-QAERPWARLRVRVYRAEGLPTVRTGLLGSLARA-LHDQNVLLDPYVRVSFLGQQGETSVRGEETAPKWNEQLSFVELFPPLTRSLRLQLRDNAPLVDVALATHVLDLRQISNSGRAA--GFNPTFGPAWVPLYGS---LPSGRLRDDLQSLNEGLGEGIWFRGRLLVAVSMEVYEGRVEPKPSQTTQRSGLSRLTGKKKKKKEKTRQGQTPAGILQPASASTSEDAPEIPSAMEVEVEDLLPLPENALASFEDFLLFGVLFEATMIDPSLAKK--PISLEISIGHAGRQEEQSGQGSRADEGSESSTLEVQPLLESEDRGAGQEEQELLGTPAQWPEPVDGNGPYLCLPLRHRKPCLHVWSCWEDYTWRLQSSNSVCKVAERLDHGLQEVEKMQRRSGPGACTR-LKQTLEEL------VAGSRQFCHGAERRTMTRPNALDRCRAKLLTHSLNLMARQGLRLLRSLRLNNMQRTVVLAKKLLARLRFLAQ---EPQPPLPDVLVWMFSGQRRVAYARIPAQDILYSVVEEERGRDCGKIQSLLL------TVPGAAPGEVCAKLELFLWLGLGKQAKACTSELPMDLLPEPSSGLPQSLYRDDFRY--------------FQLRAHLYQARGVLAADDSGLSDPFARVLISTQCQTTRVLEQTLSPLWDELLVFDQLIVDGRREHLREEPPLVVINVFDHNKFGPAVFLGRAFAAPRVKLIEDPYQRPELQFFPLRKGPQAAGEVIATFELIELD-YSGHLE-PSVPSDVEPRDLASLVEPISG------HLSLPPSVRPVLRAFRVEVLFWGLRGLGRVH----------------LFEIEKPQVVLEVAGRRVESEVLPNYRENPNFTELVRHVTVDLPEQPYLQPPLSILVIERRAFGRTVLVGSHIVPHMLRFILQGHEDPQEEEETEEETRDLVPHGPQGEKSLPEAGTSRQLL-----KAPLKKLTLGLLGQGPELEEDIP-DPEEM------------DWWSKYYASL 1319          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIK-----SLEPLALVVLHNWEDIVP-ECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNK-NIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSD-ACAKFNLFKNKKVRGWWPLV---------------------------YNPKXXXXXXXNG--LEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIVDKI 6096
            I  +KIY+  LE+  ++  F+     F LYRG+  ++ +G      F G FKG+  IY                  ES+  SF E   ++                 +     +  +VRVY+VK  NL PAD NGKADPY++V  G ++   +E YIPK LNPIFG   E+ V+ P +  L V V+D D +  DDLIGET IDLENR+ S HR  CGL S Y+ +GY  W+D+  P+ IL  LC++  +P P+Y      V++  + F + S     D  + K     S E  AL VL  W+++     +LV EH+ETRPLY    PG+ QG L MW+D+FPS    PPP+DI PR+P SYELR+VI  T++V L D N  T E+S DIY+K+W+K  + D Q+TD HF SL+G+G FNWRFVF+FDYL  E  +  + K   + ++E E++ P  L +QV D D + ++  +G L+ +L    + A+  + C      D A  + NLF+  ++RGWWP+V                             P+D +  +  G    + G VE E +L+  EEAE  P G GR+EP PLEKPNRP  SF  F+NP  T  +FI  R   IL+ +L++ +  + ++L  Y  PG  S VI   +
Sbjct: 1368 IATLKIYNSSLED--EFSHFEDWLSVFPLYRGQGGQDGEGEGASGHFVGKFKGSFLIY-----------------PESEAKSFSEPQISRG----------------VPQNRPIKLLVRVYIVKATNLAPADPNGKADPYVVVSAGKEQRDTKERYIPKQLNPIFGEVLELSVSLPAQPELTVAVFDHDLVGSDDLIGETHIDLENRFYSHHRANCGLASQYDVNGYNAWRDAFRPSQILAGLCQRCGLPVPEYRA--GAVKVGSRVFLTPSEAPPPDDRKPKVTSEASEEAQALHVLRRWQEMPGLGIQLVPEHVETRPLYHPRSPGLLQGSLHMWIDIFPSDVPAPPPVDIKPRQPISYELRVVIWNTDDVALDDVNPLTGERSSDIYVKSWVKGLEQDRQETDVHFNSLTGEGNFNWRFVFRFDYLPTEREVSVRRKPGPFALEEAEFRQPAVLVLQVWDYDRISANDFLGSLELQLPDMVRGARDPEHCSVRLALDGAGPRCNLFRCHRLRGWWPVVKMKDMEDVEREAREAQAGKKRKRKRRAGRPEDLEFTDTGGNVYILTGKVEAEFELLTVEEAEKRPVGKGRKEPEPLEKPNRPKTSFNWFVNPLKTFIFFIWRRYWRILVLLLLLALITIFLLLVFYTIPGQISEVIFSPV 1991          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKT-KPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEY------------------------------NSPVSGNENL-----GKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEP---SDDIDVK--------DGDNYSELSL------LPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIK-----TTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYS-----------------------HLPKKEENFESQYVHSL--TEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIE--YYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSD-----AKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATL 3918
            M+L+V L+++T ++   +   KV FR   F +   +  +        F WPI  ++D  + L I+    ++   ++L G   +VL  ++ +  + + +T +D+        ++ EI+Y                              +S +SG         G+S   +P++   K  +          T + + D   GD+     ++D+D K        D D  S  S+      +  +  K    ++P S +  D+QISVT+ EAR L G N++P+  V  G++K+ T +K  TN P+YNEYF FDF +    + ++II+I  +  K+ + +     G ++G F +D  TVY+   H F +KWA+L DP   T+G KG+VK D++V+  GD  K P+K  + ++ +IE N+L+P+ +  ++R      V +Y+AE LP MNT IM+N+K+A +G+ + L DPYV V FAG  G T V   SY P WN+Q+IFTE FPP   RL++ +RDSD + D  I T FIDL K+ N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLLI+I      TTS        V +   + +S +  GK E + LF S  EAT+I ++IG   KP++FE++IG  G   D  S                       H   +EE  +   + S+  T P      D  YFH+PY  KKPC+Y+ +  +D R RL+  NI+DK+  +L E +  V  +  + +K    R ++  +E    S  + ++     +  + +T LD +  K     +E M          +   T+   +K + +F++ L     +PQH +PDVF++MI +N R+AY RI ++D+++S +  E G+ CG V  V+L+      LP K       + +QA+L++YLWLGL K  + + +GLP GF      K      +PP  + Y  +  FQLR ++Y  R+L  +D SGLSDPF +V    H + + V  ET  P WD+ ++ DN+        ++  PP +V+E++D D+    EFIGR F +P   +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  +       P ++          D+ +G      L +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I+++  +PNF+  +    + LP N    PP++I  ++   FG   +VG+H +T L +  Y   DK   +  H  D + +++ + ++K     V  +A           T A VK D      + +       + E++    P E M   DWW++Y+A++
Sbjct:    1 MALVVHLKTVTELRGKGDRIAKVTFRGLSFFSRVLENCEDEARFEQAFRWPIGSQVDGDEMLEIQVFNYSKVFTNRLIGTFRMVLQKVVEEGHLEVSDTLIDDNNTAIQTTISIEIKYQTMDGSVKVWSDGEFLDIPDDLDGTFQFETDSLLSGRSQSSGTSPGRSIHGIPTFR--KAGKGVFSAMKLGKTRTSKDDHKKGDDAAILDAEDLDRKAMRLGGILDPDTISLASVTAVTTNVSNKRSKPDIKMEPSSGRPVDYQISVTVIEARQLVGLNMDPVVCVEIGEEKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKIIKISVIHSKNLLRS-----GTLVGTFKLDVGTVYTQPEHQFHHKWAMLSDPDDITTGCKGYVKCDIAVVGKGDNIKTPHKASEADEDDIEGNLLLPEGV-PSERQWARFYVKIYRAEGLPKMNTSIMANVKKAFIGENRDLVDPYVLVQFAGQKGKTSVQKSSYEPIWNEQVIFTEMFPPLCRRLKVQIRDSDKVNDVAIGTHFIDLRKVSNDGDK---GFLPTMGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLISIAVEILDTTSAEIMSSTEVHMEPVSNISESATGKMEEFFLFGSFLEATMIDRKIGD--KPISFEVTIGNYGNQIDGVSKPALAKKKKEGGGESEEEESELIHNSSEEEAEDDGDLTSVPSTPPMKPVITDRNYFHLPYFEKKPCIYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEII-KTEKAYPERRLRGVLEELSTSCSRFVTLANKDQNLSGRTKLDRERLKSCMREMESMGQQAKTIRTQVKRNTVRDKLKLVLNFLQRLRFLADEPQHSIPDVFIWMISNNKRIAYARIPSKDILYSIVDEEMGKDCGKVKAVFLR------LPGKKGFGPAGWTVQAKLEMYLWLGLNKQRKDFLIGLPSGFEENKAVKGIGIQAVPPISLVYNMKQVFQLRAHMYQARSLFAADTSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDNVELYGEAGELRDDPPIIVIELYDQDTVGKAEFIGRTFAKPLTKMVDEHYGPPRFPPQLEYYQIYRGNCAAGDLLAAFELLQIGPAGR----AALPPIDG-------PTDSDRG----PILPVPLGIRPVLSRYRIEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYILVGSHAVTTLRKFIYSPPDKTANNWAHTGDIVVNMSPEPNIKKMDTVVKIEA----------TTDAVVKVDLNEDEKEKEKKKKKKKKGEEVEEEEPDESM--LDWWSKYFASI 1326          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEI-QDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            ++ + +Y+ ELE+  ++G F+    +F+LYRGK  ++DD   + +DR  G FKG++C+Y +   + I  +  FD +                             +  F S PH+  ++ +VR+Y+++  +LHPADINGKADPYI++++G  +IRD+ENYI K LNP+FG+ F++E TFP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+ S Y+ HGY  W+D Q P  IL  LC++  +  P Y      V++  + F   + IED+ G + ++ E LAL VL +WE+I P   CKL+ EH+ETRPL   +KPGIEQG +EMWVDMFP     P P IDISPRKP  YELR++I  T+ V L D ++FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRFVF FDYL AE+ IV  K ++++  DE EYK P  L +QV D+D   +D  +G ++  L+KFP+ AK  K C  D           ++FK K+V+GWWP V       + E +  E+ G VE E+ L+  EEAE +P GLGR +P PLEKPNRPD S + F+NP  +I+YFI
Sbjct: 1399 VDELMVYNKELES--EFGSFEDWLHTFNLYRGKAGDDDDHNVVDEDRIVGRFKGSLCMYKLPLSEEITREAGFDPN-----------------------------MGMFQSIPHNDPINVLVRIYIIRATDLHPADINGKADPYIVIKLGKSDIRDKENYISKQLNPVFGKSFDIEATFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGIASNYSVHGYNVWRDPQKPAQILAKLCKEGKLDGPHYGP-GGRVKVANRIFLGPTEIEDESGLKKQTEEHLALTVLRHWEEI-PRVGCKLIPEHVETRPLLNPDKPGIEQGRIEMWVDMFPMDVPAPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFDYLMAEEKIVISKKESMFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNKFPRGAKTAKQCSLDMVLKEHELPTISIFKQKRVKGWWPFV------AQNENDEFELTGKVEAELHLLTAEEAEKSPVGLGRNDPEPLEKPNRPDTSLMWFMNPLRSIRYFI 1953          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKT-KPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVS-----------GNENL--------------------------------GKSDFNVPSYNLTKLERHEGHIRLPSDTSSVE-SDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPK---HIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH----LPKKEENFESQY------------------VHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            M+L++ L++++ ++   +   KV FR   F +   +  +   +    F WP+A  +D+ + L I+    ++   +KL G   +VL  ++ +  + + +T +D+   I   +L  E+ Y +              G+E+L                                G+S F+  +  L K   H+   + P + + +E  D D+      D +D       S  +L      K  K    ++P + +  D+Q+S+T+ EAR L G N++P+  V  G  K+ T +K  TN P+YNEYF FDF +S   + ++II+I  +  K+ + +     G ++G F +D  TVYS   H F +KWA+L DP   +SG KG+VK D++V+  GD  K P+K ++ ++ +IE N+L+P+ +   +R      V +Y+AE LP MNT +M+N+K+A +G+ K L DPYV+V FAG  G T V   SY P WN+Q++FT+ FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLL+ +      TS P+ +    V V    P+S + AGK E + LF +  EA++I +  G   KP+TFE++IG  G   D  S      P+KE   E +                     S T P      D  YFH+PY  +KPC+Y+ +   D R RL+  NI+D +  +L E +  +  +  + +K    R ++  +E       + LS     +G + +T LD +  K     LE M     +    +   T+   ++   +F++ L     +PQH +PD+F++M+ +N RVAY R+ ++DL+ S +  E G+ C  V T++LK      LP K       + +QA++++YLWLGL K  + +  GLP GF      +       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DN+        ++  PP +V+EI+D DS    +F+GR F +P V +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  K           +L  +   V D  +G      + +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNFN  +    + LP N    PP++I  ++   FG   +VG+H ++ L  +
Sbjct:    1 MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFS--AMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRS-----GTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGV-PPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDK---GFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGD--KPITFEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMI-KTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLK------LPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK----------ADLPPINGPV-DVDRG----PIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF 1229          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDI-VPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDA--CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            I+ +K+Y  ELE+  ++  F+    +F+L RGK  +++DG   ++R  G FKG++C+Y V       +D+  E   +S    F                         +DP  ++ +VRVYVV+  +LHPADINGKADPYI +R+G  +IRD+ENYI K LNP+FG+ F++E +FP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY+ HGY  W+D   P+ IL  LC+   +  P +      V++  + F   S IED++G +  + E +AL+ L +WEDI    C+LV EH+ETRPL   +KPGIEQG LE+WVDMFP     P  P+DISPRKP  YELR++I  T+ V L D +FFT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWR++F FDYL AE+ IV  K ++++  DE EYK P  L +Q+ D+D   +D  +G ++  L++FP+ AK  K C     +        ++FK K+V+GWWPL+         E +  E+ G VE E+ L+  EEAE NP GL R EP PLEKPNRPD SF+ FLNP  + +YF+
Sbjct: 1405 IDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVP----LPEDVSREAGYDSTYGMF--------------------QGIPSNDP--INVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLL------ARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFL 1958          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKT-KPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSP---------------------------------------VSGNENLGKSDFNV-PSYNLTKLERHEGHIRLPSDTSSVE-SDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPK---HIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH----LPKKEENFESQY------------------VHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            M+LIV L++++ ++   +   KV FR   F +   +  +   +    F WP+A  +D+ + L I+    ++   +KL G   +VL  ++ +  + + +T +D+   I   +L+ E+ Y +                                        +SG ++  ++  +V  +  L K   H+   +   + + +E  D D+   +  D +D       S  +L      K  K    ++P + +  D+Q+S+T+ EAR L G N++P+  V  G  K+ T +K  TN P+YNEYF FDF +S   + ++II+I  +  K+ + +     G ++G F +D  TVYS   H F +KWA+L DP   ++G KG+VK D++V+  GD  K P+K ++ ++ +IE N+L+P+ +   +R      V +Y+AE LP MNT +M+N+K+A +G+ K L DPYV+V FAG  G T V   SY P WN+Q++FT+ FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RL++ +      TS P+ +    V V    PVS +  G+ E + LF +  EA++I ++ G   KP+TFE++IG  G   D  S      P+KE   E +                     S T P      D  YFH+PY  +KPC+Y+ +   D R RL+  NI+D +  +L E +  V  +  + +K    R ++  +E       + LS     +G + +T LD +  K     LE M          +   T+   ++   +F++ L     +PQH +PDVF++M+ +N R+AY R+ ++DL+ S +  E G+ C  V T++LK      LP K       + +QA+L++YLWLGL K  + +  GLP GF      +       PP  + Y ++  FQLR ++Y  R+L  +D SGLSDPF +V      + + V +ET  P WD+ ++ DN+        ++  PP +V+EI+D DS    +F+GR F +P V +  + Y   +    L+++ +YRG+  AGD+L +F+L++I P  K       P +   ++M        +G      + +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNFN  +    + LP N    PP++I  ++   FG   +VG+H ++ L  +
Sbjct:    1 MALIVHLKTVSELRGKGDRIAKVTFRGQSFYSRVLENCEGVADFDETFRWPVASSIDRNEVLEIQIFNYSKVFSNKLIGTFCMVLQKVVEENRVEVTDTLMDDSNAIIKTSLSMEVRYQATDGTVGPWDDGDFLGDESLQEEKDSQETDGLLPGSRPSTRISGEKSFRRAGRSVFSAMKLGKTRSHKEEPQRQDEPAVLEMEDLDHLAIQLGDGLDPDSVSLASVTALTSNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRS-----GTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGV-PPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDK---GFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRKNGD--KPITFEVTIGNYGNEVDGMSRPLRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLASVSSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMI-KTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGRSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDVFIWMMSNNKRIAYARVPSKDLLFSIVEEELGKDCAKVKTLFLK------LPGKRGFGSAGWTVQAKLELYLWLGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGSATAGDLLAAFELLQIGPSGK----ADLPPINGPVDM-------DRG----PIMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF 1228          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDA--CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            I+ +K+Y  ELE+  ++  F+    +F+L RGK  +++DG   ++R  G FKG++C+Y V   +++  +  +D         ++G                      F   P +  ++ +VR+YVV+  +LHPADINGKADPYI +++G  +IRD+ENYI K LNP+FG+ F++E +FP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY+ HGY  W+D   P+ IL  LC++  +  P +   +  V +  + F   S IED++G +  + E +AL  L +WEDI P   C+LV EH+ETRPL   +KPGIEQG LE+WVDMFP     P  P+DISPRKP  YELR+++  T+ V L D +FFT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWR++F FDYL AE+ IV  K ++++  DE EYK P  L +Q+ D+D   +D  +G ++  L++FP+ AK  K C     +        ++FK K+V+GWWPL+         E +  E+ G VE E+ L+  EEAE NP GL R EP PLEKPNRPD SF+ FLNP  + +YF+
Sbjct: 1405 IDELKVYPKELES--EFDSFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYD--------PTYG---------------------MFQGIPSNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNIWRDPMKPSQILTRLCKEGKVDGPHFGP-HGRVRVANRVFTGPSEIEDENGQRKPTDEHVALSALRHWEDI-PRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLL------ARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFL 1958          

Query:  646 IDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH----LPKKEENFESQY------------------VHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            ++P + +  D+Q+S+T+ EAR L G N++P+  V  G  K+ T +K  TN P+YNEYF FDF +S   + ++II+I  +  K+ + +     G ++G F +D  TVYS   H F +KWA+L DP   ++G KG+VK D++V+  GD  K P+K ++ ++ +IE N+L+P+ +   +R      V +Y+AE LP MNT +M+N+K+A +G+ K L DPYV+V FAG  G T V   SY P WN+Q++FT+ FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RL++ +      TS P+ +    V V    PVS +  G+ E + LF +  EA++I ++ G   KP+TFE++IG  G   D  S      P+KE   E +                     S T P      D  YFH+PY  +KPC+Y+ +   D R RL+  NI+D +  +L E +  V  +  + +K    R ++  +E       + LS     +G + +T LD +  K     LE M          +   T+   ++   +F++ L     +PQH +PDVF++M+ +N R+AY R+ ++DL+ S +  E G+ C  V T++LK      LP K       + +QA+L++YLWLGL K  + +  GLP GF      +       PP  + Y ++  FQLR ++Y  R+L  +D +GLSDPF +V      + + V +ET  P WD+ ++ DN+        ++  PP +V+EI+D DS    +F+GR F +P V +  + Y   +    L+++ +YRG   AGD+L +F+L++I P  K       P +   ++M        +G      + +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNFN  +    + LP N    PP++I  ++   FG   +VG+H ++ L  +
Sbjct:  259 MEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRS-----GTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGV-PPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDK---GFLPTLGPAWVNMYGSTRNYT---LLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRKNGD--KPVTFEVTIGNYGNEVDGTSRPQRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLASVSSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMI-KTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGHSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDVFIWMMSNNKRIAYARVPSKDLLFSIVEEELGKDCAKVKTLFLK------LPGKRGFGSAGWTVQAKLELYLWLGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQTFQLRAHMYQARSLFAADSTGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPSGK----ADLPPINGPVDM-------DRG----PIMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF 1244          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDA--CAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYR 5985
            I+ +K+Y  ELE+  ++  F+    +F+L RGK  +++DG   ++R  G FKG++C+Y V   +++  +  +D         ++G                      F   P +  ++ +VR+YVV+  +LHPADINGKADPYI +++G  +IRD+ENYI K LNP+FG+ F++E +FP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+  TY+ HGY  W+D   P+ IL  LC++  +  P +   +  V++  + F   S IED++G +  + E +AL  L +WEDI P   C+LV EH+ETRPL   +KPGIEQG LE+WVDMFP     P  P+DISPRKP  YELR+++  T+ V L D +FFT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWR++F FDYL AE+ IV  K ++++  DE EYK P  L +Q+ D+D   +D  +G ++  L++FP+ AK  K C     +        ++FK K+V+GWWPL+         E +  E+ G VE E+ L+  EEAE NP GL R EP PLEKPNRPD +F+ FLNP  +IKY I  R
Sbjct: 1401 IDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYD--------PTYG---------------------MFQGIPSNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNIWRDPMKPSQILTRLCKEGKVDGPHFGP-HGRVKVANRVFTGPSEIEDENGQRKPTDEHVALSALRHWEDI-PRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLL------ARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTR 1957          

Query:  511 SDTSSVESDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKV-IGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT-------------------------------------------TSQPDSIKIG---VDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKK------EENF-------ESQYVHSLTEPKYAYTF---------DNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKM-KMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFT----SKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLE--NLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLD--HESDHLQ-------SLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVT--------------NPVPGEPEK-----------------LIRFVPKEEMESA-DWWTRYYATLGDLDDPNLYKPEDEILVESESEDEIRRDI 4005
             DT +++ +  + +  P  D+   D   +   S  P+R  KL   I    ++ +++QI++TI EAR L G+NI+P+  +  G +K+ + +K  TN+PFYNEYF FDF   ++ L ++II+I         V  H   G V IG F +D  TVY+   H F  KWA+L DP    +G KG++K D+SV+  GD  K   KT   E+P IE N+LIP      +R      V +Y+AE LP MN+ IM+N+ +A +GD K L DP+VEVSFAG  G T V      P W++Q+IF E FPP   R++I V D   + D  ++T FIDL KI N  + ++ GFLPT+GP+WINLYG+PR +S   ++   Q  N+   EGV+FRGR+L+ I                                              SQ  S K     V+V S +     V  K E +LLF + FEAT+I ++IG K  P++FE+SIG  G   D  SH   K      EE+        +    H +  P  + T          +  Y ++P+ +KKPC+Y I+   D   RL   N+L+K+   L E + +V  L    ++    + +K  +  F       +S  +       +T LD K   L    LE M K +  +  +     ++D  I +  +FV+ +   + +PQH +PDVF++M+ +N RVAY RI ++DL++S +  + G+ CG + T +LK        +   +++QA++ +YLWLG +K        LP G+  +  +    +  PP  + Y E+  FQLR ++Y  R LI +D +GLSDPF KV    H + + +  +T SP W++ ++ +++V + + K +   PP VV+E++D D+    E++G     P V +   +Y   +L +  ++ G +  GD+L  F+L+++ P      + G P +E  ++ ++                  +P ++RP +  +R+E+L WGVR++++++++S                V++P+ +IE GG  +KS +I+ +  +PNF+    +  + LP N    PP+SI  +++  FG   +VG + I  L ++    K+ E L    + D  Q       SLTA     A+S      A     +  P  T     + A+P +                PV  EP K                   R +  E  E+  DWW++YYA+L          P+ +        DE+  DI
Sbjct:   29 GDTEALQEEPSHQEG-PRGDLVHDDASIFPVPSASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKIS--------VFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEP-IEKNLLIPNGF-PLERPWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDK-GFLPTFGPAWINLYGSPRNHS---LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFFEATMIDRKIGDK--PISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADFLEESIEEVRELIKISQEAPEEK-MKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPG----KRPAGWSVQAKVDVYLWLGSIKHASAILDNLPVGYEAEMSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSG----LQGLPPVEPPDITQIYP----------------VPANIRPVLSKYRVEVLFWGVREMKKVQLLS----------------VDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLC--KLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDI 1250          

Query: 4234 IKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMI-EDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDS-IVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCD--PFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIV 6087
            ++IY  +LE+  ++  F+   ++F L+RGK  E+D G +  DR  G FKG+ CIY   +D+  E        D  +L                      ++ + +   H V  ++RVY+V   NL PAD +GK+DPYI++++G  EI+DR+ YIPK LNP+FGR FE++ TFP+ES L + +YD D +  DDLIGET IDLENR+ S HR  CGL S Y   GY  W+D+  PT IL  LC+ N +  P +      ++I  + F+  ++  E+D    ++S E LAL VLH+WEDI PE  C+LV EHIETRPLY ++KPG+EQG L+MWVDMFP     P PP+DISPR+P  YELR+ I  TE+V L D N FT +KS DIY+K W+K  + D Q+TD H+ SL+G+G FNWRF+F F YL AE   ++ K +NI+ +++ E KTP  L +QV D + L SD  +G L+  L+ FP+ AK  K+CD   F+++    K ++F+ K+VRGWWP                E+ G VE E  LV  EEAE NP G  R+EP PL KPNRPD SF  F++P+  + Y I    K  +I   I++I ++ +VLFIY  PG  SR IV
Sbjct: 1277 LQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLD-GDRVIGKFKGSFCIYKSPQDSSSE--------DSGQL----------------------RIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP--GKIQIGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDI-PEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPF-----------SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDH-QFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVP------------SYNLTKLERHEGHIR----LPSDTSSVESDSDNGDNEPS-----DDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPK-RPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT-------TSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTG------------------------------------------ICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKS-CRGT--AKKTLLDVKYQKLIRMGLEKMKMSWSVTIECL--------------SVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIR---------------VAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKM-GLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFI---RGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGF-PSLENLMEMTAQVNDNSKGEKDE-------EKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINE-----------------DLDHESDHLQSL-TAQFDMKANSD-GVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTN-------------------------------------PVPGE------PEKLIRFVP-KEEMESADWWTRYYATLGDLDD-------PNLYKPEDE-----ILVESESE-DEIRRDIFLGYRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLF-----QHKSTKELFLKEVQEHLILEDEKLS------DNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPP-IDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNI-YEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQ--HSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            M+LIV+L+SL G++   +  +KV FR + Q  +P   ++     G +F WP+ R +D+ DSL I+    ++   ++  GV+ I L  L     ++L E  +D     T++ L+ E+ Y SP S   +  + DF  P             +N  +     GH       P+D  ++ ++S   D+  S     D+      D  S L     +  ++   +DP   +++DFQ+SVTI EAR LSG NINP  EV  G Q + T+ +M TN+P+YN+YF+F+FR ++ +LM+Q+I I+A++K S +++R +F G +IGEF +D +TVYS     FF KWA LIDPK   SG KG+VK D++VL  G+K K +P KT   ++ +IEAN+L+P I    +R + ++SV +Y+AE LP MNT +M++IKQA+ GD K LADPYV+VSFAG++  TK I  SY+P WN+ IIFTE FPP  +R+RI++ D D + +E I+T FIDL +IMN++   E G LP +GPSW+NLYGTPR Y+Y  M    +  N  + EGVA+RGRLL+AIKT              K G  V S   V   V G++E YLL   +F+A  I  +IGKK K LTFELSIGT G                                          +     +   +K      Q+  S + P         Y+H+P+  +KPCLY+    EDHR R+ I NILD+L  E    + +   L SR K+    R ++ ++     +I    + +++ C GT    +T LD + +  +R+ LEK ++        L              S  ++   ++D  +  + + +   +PQH LPDVF++++  +                 +A+ R+ AR ++ +A   E G+ CG V T++L+K       Q + + +Q QL++ LWLG  ++        +P G+  D    + PP  + Y E +  + R Y++M RNLIGSD+SGLSD F +V+IG+ +  + V  E+ SP+WD T+ +  ++   N   V   PP VV+E+FD D+    EF+GR FCRP V +   + DEY   +L WW VYRG + AG++L SF+L+++D   +    P F  SLE +   +A +   S G  D+         L +P  VRP +  +R+E+L WGVR L R+++ S                V+ PRI +E GG R+ S+ IE     PNF  NL  + L LPVN  +WPP+   C +   FG   +VGNHV+  +++Y  +DK                    +  H  D L +  TA+    A+S  GV N +F  + E  PE         A P  T+                                      +PG       P+K  +  P +E++   DWW R+YA + +LDD       P      DE     I VE  SE D    D  +   VE    D++ +     +    +KK++K  KKKK+K+R F     + K  +  +L E  E    +DE+        DN W+ ++K+Y   LE ++D+GGF   F +F LYRGKQE  DD    + R  G+FKGN+C+Y + +           +  E  L S                     L+K L   + V  +VRVY+V+ ++LHPAD NGK+DPY+++R+GN  I ++ENYIPK LNP+FG+CFE+E  FPQ+S L + V DWD L+ DDLIGET IDLENR  S HR TCGL   Y+  GY +W+D QLP+ IL  LC +N + PPKY+     V + G+TF   S +ED+ G++ +S EPLAL VL+NW D V    LV EH+E+RPL+  EKPGIEQG +EMWVD+FP+    PPP +DISPR+P +YELR++I  T  V+L +T+  +     DI++K WMK   ID Q TD H+RSL+G+G FNWRF+FQF+YLKAED IVYK K+  + IDE E K PC L++QV D+D++ +D  +G L  RLS+ P+ AK  K+C  FQ          ++F+N++ RGWWP +   +DE  E+    E+GG V+ E+ L+   EAE+NPAGLGR EP PL +PNRP+ SF   L+P   +K+ I
Sbjct:    1 MALIVSLRSLDGLEGKSDRILKVTFRGNTQTTSPVASSRFQCYFGQQFQWPVGRPIDEADSLEIRAYNYSKILNNRQIGVLRISLQHLAETGSLDLREHLIDANNAPTNVILDCELRYYSPDSRIGDWQQDDFLYPVDGGVLKDGDGSDFNDDEALEAGGHAEDEADWPADARALLANS--ADDRLSSLQFEDEAASMLSDGASSLGNEMRKTLEVAAVLDPTLHRMEDFQVSVTIVEARQLSGANINPCVEVRIGDQLKRTDTQMSTNSPYYNQYFAFEFRTTKADLMDQVIHIRAVNKGSMMISR-LFAGDLIGEFRLDVRTVYSAPDRMFFQKWACLIDPKDALSGPKGYVKCDINVLGKGEKLKVQPKKTKSSDEEDIEANLLLP-IGVPIKRQMADISVIIYRAEGLPKMNTDLMASIKQALAGDSKPLADPYVQVSFAGHSAKTKSIKNSYNPHWNEAIIFTELFPPLCNRIRISLFDWDAVYNECIATHFIDLGQIMNNS---ENGHLPIFGPSWVNLYGTPRNYNYENMFHPKEELNHGMGEGVAYRGRLLMAIKTEIKQAGGVGGGGGSKAGARVVSAAQVPEAVTGRKEDYLLAGILFDAGAIDADIGKKGKLLTFELSIGTHGNHVDGSFDDASDEDSADEASDFSDSAAGEDSDAELEGAQNRRLLAGGTAVAKEKLRGQRHQWCRSQSRPLMPLPAHEDYYHVPFMERKPCLYIRFGHEDHRQRMLIANILDRLCSEFESGIEEAQELVSREKRGAPSR-LRDALRRLSGAIPTASTTVRTVCHGTRAGPRTRLDQRRELAVRLALEKARVKSGALARQLRRHCAKAATNSSGGSASSLRGHLRDCRALARRIRELAEEPQHALPDVFVWLLAQDGGGGGGGQRQRRRQQQRLAFARLPARQVLQAAGEHETGRDCGRVITLFLRKPGRKGAGQ-SGWTLQCQLKLLLWLGPFREAATSLWPAVPAGYLGDPMRRRRPPSELVYGERTVLEFRAYVFMARNLIGSDESGLSDAFARVVIGDQVVSTHVIPESLSPVWDRTLSVTPLIIYLNEVDVLNHPPVVVVEVFDDDTIGKSEFLGRCFCRPQVTLLSSQQDEYRPPQLDWWEVYRGQLNAGELLASFELVQLDANGR---TPDFVESLEQIRIASANIPRGSSGRGDDSDATVQSHHLPVPQSVRPQLAPYRIEVLFWGVRDLARVQLQS----------------VDSPRIEVEFGGRRVWSETIESCRLKPNFPRNLKCLDLMLPVNRWYWPPLMFQCEDSRQFGRTVLVGNHVVPSVLKYIRKDKSERRDKSGTVSSVAASNNIGNRKHWKDQLTAAKTAKTPTAASSAAGVDNPSFIPEPETEPEVLAGHPAGTADPPGTSQAAQAALPAITAEAAGSEVGQSSEARTLDLAAENGQGTIPGTAMDLKLPQK--KLPPSREDLLEMDWWGRFYAAIDNLDDEIVDQTDPESDSDTDEDILRDIDVEIRSEGDPAAEDNIVDIPVEEVKVDKKKQKKAEKKAKKLRKKRQKLLKKKKRKERRFRLPFGERKDARAAYLAEKHED---DDEQQGGRPHGEDNGWVSQMKLYHQPLEAVRDFGGFSHAFHTFPLYRGKQE--DDDAPPESRAVGIFKGNLCVYQISQAEF--------EAPEPTLPSL------------------FTLHKDLPSNNPVSVLVRVYIVRCVDLHPADPNGKSDPYLILRLGNTTINEKENYIPKQLNPVFGKCFELEAKFPQDSGLQLLVMDWDLLSGDDLIGETRIDLENRLYSRHRATCGLPIEYSTFGYNRWRDQQLPSTILARLCRENELDPPKYEPAYSRVTVDGRTFYEHSEVEDEAGNKTQSNEPLALKVLNNW-DQVTGVALVPEHVESRPLFSPEKPGIEQGRVEMWVDLFPTELGSPPPQVDISPRQPVAYELRVIIWDTAEVKLDETD-LSGASCSDIFVKGWMKGLGIDEQVTDVHYRSLTGEGNFNWRFIFQFEYLKAEDKIVYKVKDSPFAIDEEERKAPCQLHLQVWDADIVSADDFLGGLDLRLSRLPRGAKSAKACGAFQLERDSGVRAISIFRNRRCRGWWPFIGESEDEPGEQ----ELGGKVDAELQLLTAAEAEANPAGLGRSEPQPLPEPNRPETSFNFLLSPLKALKFLI 2114          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDH-QFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVP------------SYNLTKLERHEGHIR----LPSDTSSVESDSDNGDNEPS-----DDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPK-RPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT-------TSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTG------------------------------------------ICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKS-CRGT--AKKTLLDVKYQKLIRMGLEKMKMSWSVTIECL--------------SVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIR---------------VAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKM-GLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFI---RGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGF-PSLENLMEMTAQVNDNSKGEKDE-------EKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDK--------------INEDLDHESDHLQSLTAQFDMK-----ANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTN-------------------------------------PVPGE------PEKLIRFVP-KEEMESADWWTRYYATLGDLDD---PNLYKPEDE-----ILVESESE-DEIRRDIFLGYRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLF-----QHKSTKELFLKEVQEHLILEDEKLS------DNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPP-IDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNI-YEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQ--HSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            M+LIV+L+SL G++   +  +KV FR + Q  +P   ++     G +F WP+ R +D+ DSL I+    ++   ++  GV+ I L  L     ++L E  +D     T++ L+ E+ Y SP S   +  + DF  P             +N  +     GH       P+D  ++ ++S   D+  S     D+      D  S L     +  ++   +DP   +++DFQ+SVTI EAR LSG NINP  EV  G Q + T+ +M TN+P+YN+YF+F+FR ++ +LM+Q+I I+A++K S +++R +F G +IGEF +D +TVYS     FF KWA LIDPK   SG KG+VK D++VL  G+K K +P KT   ++ +IEAN+L+P I    +R + ++SV +Y+AE LP MNT +M++IKQA+ GD K LADPYV+VSFAG++  TK I  SY+P WN+ IIFTE FPP  +R+RI++ D D + +E I+T FIDL +IMN++   E G LP +GPSW+NLYGTPR Y+Y  M    +  N+ + EGVA+RGRLL+AIKT              K G  V S   V   V G++E YLL   +F+A  I   IGKK K LTFELSIGT G                                          +     +   +K      Q+  S + P         Y+H+P+  +KPCLY+    EDHR R+ I NILD+L  E    + +   L SR K+    R +  ++     +I    + +++ C GT    +T LD + +  +R+ LEK ++        L              S  ++   ++D  +  + + +   +PQH LPDVF++++  +                 +A+ R+ AR ++ +A   E G+ CG V T++L+K       Q + + +Q QL++ LWLG  ++        +P G+  D    + PP  + Y E +  + R Y++M RNLIGSD+SGLSD F +V+IG+ +  + V  E+ SP+WD T+ +  ++   N   V   PP VV+E+FD D+    EF+GR FCRP V +   + D+Y   +L WW VYRG + AG++L SF+L+++D   +    P F  SLE +   +A +   S G  D          L +P  VRP +  +R+E+L WGVR L R+++ S                V+ PRI +E GG R+ S+ IE     PNF  NL  + L LPVN  +WPP+   C +   FG   +VGNHV+  +++Y  +DK               + ++ +       LTA    K     +++ GV N +F  + E  PE         A P  T+                                      +PG       P+K  +  P +E++   DWW R+YA + +LDD   P      DE     I VE  SE D    D  +   VE    D++ +     +    +KK++K  KKKK+K+R F     + K  +  +L E  E    +DE+        DN W+ ++K+Y   LE ++D+GGF   F +F LYRGKQE  DD    + R  G+FKGN+C+Y + +           +  E  L S                     L+K L   + V  +VRVY+V+ ++LHPAD NGK+DPY+++R+GN  I ++ENYIPK LNP+FG+CFE+E  FPQ+S L + V DWD L+ DDLIGET IDLENR  S HR TCGL   Y+  GY +W+D QLP+ IL  LC +N + PPKY+     V + G+TF   S +ED+ G++ +S EPLAL VL+NW D V    LV EH+E+RPL+  EKPGIEQG +EMWVD+FP+    PPP +DISPR+P +YELR++I  T  V+L +T+  +     DI++K WMK   ID Q TD H+RSL+G+G FNWRF+FQF+YLKAED IVYK K+  + IDE E K PC L++QV D+D++ +D  +G L  RLS+ P+ AK  K+C  FQ          ++F+N++ RGWWP +   +DE  E     E+GG V+ E+ L+   EAE+NPAGLGR EP PL +PNRP+ SF   L+P   +K+ I
Sbjct:    1 MALIVSLRSLDGLEGKSDRILKVTFRGNTQTTSPVASSRFQCYFGQQFQWPVGRPIDEADSLEIRAYNYSKILNNRQIGVLRISLQHLAETGSLDLREHLIDANNAPTNVILDCELRYYSPDSRIGDWQQDDFLYPVDGGVLKDGDGSDFNDDEALEAGGHAEDEADWPADARALLANS--ADDRLSSLQFEDEAASMLSDGASSLGNEMRKTLEVAAVLDPTLHRMEDFQVSVTIVEARQLSGANINPCVEVRIGDQLKRTDTQMSTNSPYYNQYFAFEFRTTKADLMDQVIHIRAVNKGSMMISR-LFAGDLIGEFRLDVRTVYSAPDRMFFQKWACLIDPKDALSGPKGYVKCDINVLGKGEKLKVQPKKTKSSDEEDIEANLLLP-IGVPIKRQMADISVIIYRAEGLPKMNTDLMASIKQALAGDSKPLADPYVQVSFAGHSAKTKSIKNSYNPHWNEAIIFTELFPPLCNRIRISLFDWDAVYNECIATHFIDLGQIMNNS---ENGHLPIFGPSWVNLYGTPRNYNYENMFHPKEELNRGMGEGVAYRGRLLMAIKTEIKQAGGVGGGGGSKAGARVVSAAQVPEAVTGRKEDYLLAGILFDAGAIDANIGKKGKLLTFELSIGTHGNHVDGSFDDASDEDSADEASDFSDSAAGEDSDAELEGAQNRRLLAGGTAVAKEKLRGQRHQWCRSQSRPLMPLPAHEDYYHVPFMERKPCLYIRFGHEDHRQRMLIANILDRLCSEFESGIEEAQELVSREKRGAPSR-LHDALRRLSGAIPTASTTVRAVCHGTRAGPRTRLDQRRELAVRLALEKARVKSGALARQLRRHCAKAATNSSGGSASSLRGHLRDCRALARRIRELAEEPQHALPDVFVWLLAQDGGGGGGGQRQRRRQQQRLAFARLPARQVLQAAGEHETGRDCGRVITLFLRKPGRKGAGQ-SGWTLQCQLKLLLWLGPFREAATSLWPAVPAGYLGDPMRRRRPPSELVYGERTVLEFRAYVFMARNLIGSDESGLSDAFARVVIGDQVVSTHVIPESLSPVWDRTLSVTPLIIYLNEVDVLNHPPVVVVEVFDDDTIGKSEFLGRCFCRPQVTLLSSQQDDYRPPQLDWWEVYRGQLNAGELLASFELVQLDANGR---TPDFVESLEQIRVASANIPRGSSGRGDHSDATVQSHHLPVPPSVRPQLAPYRIEVLFWGVRDLARVQLQS----------------VDSPRIEVEFGGRRVWSETIESCRLKPNFPRNLKCLDLMLPVNRWYWPPLMFQCEDSRQFGRTVLVGNHVVPSVLKYIRKDKSERRDKSGTVSSVAASNNIGNRKHWKDQLTAAKTAKTPTAVSSAAGVDNPSFIPEPETEPEVLAGHPAGTADPPGTSQAAQAALPAITAEAAGSEVGQSSEARTLDLAAENGQGTIPGTAMDLKLPQK--KLPPSREDLLEMDWWGRFYAAIDNLDDETDPESDSDTDEDILRDIDVEIRSEGDPAVEDNIVDIPVEEVKVDKKKQKKAEKKAKKLRKKRQKLLKKKKRKERRFRLPFGERKDARAAYLAEKHED---DDEQQGGRPHGEDNGWVSQMKLYHQPLEAVRDFGGFSHAFHTFPLYRGKQE--DDDAPPESRAVGIFKGNLCVYQISQAEF--------EAPEPTLPSL------------------FTLHKDLPSNNPVSVLVRVYIVRCVDLHPADPNGKSDPYLILRLGNTTINEKENYIPKQLNPVFGKCFELEAKFPQDSGLQLLVMDWDLLSGDDLIGETRIDLENRLYSRHRATCGLPIEYSTFGYNRWRDQQLPSTILARLCRENELDPPKYEPAYSRVTVDGRTFYEHSEVEDEAGNKTQSNEPLALKVLNNW-DQVTGVALVPEHVESRPLFSPEKPGIEQGRVEMWVDLFPTELGSPPPQVDISPRQPVAYELRVIIWDTAEVKLDETD-LSGASCSDIFVKGWMKGLGIDEQVTDVHYRSLTGEGNFNWRFIFQFEYLKAEDKIVYKVKDSPFAIDEEERKAPCQLHLQVWDADIVSADDFLGGLDLRLSRLPRGAKSAKACGAFQLERDSGVRAISIFRNRRCRGWWPFIGESEDEPGEP----ELGGKVDAELQLLTAAEAEANPAGLGRSEPQPLPEPNRPETSFNFLLSPLKALKFLI 2110          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLT-KLERHEGHIRLPSDTSSVESDSDNGDNEPSDDIDVKDGD--NYSELSLLPE-RDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQIL-CQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSI-KIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTG-----------ICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKM-SWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTA-------------------------QVNDNSKGEKDEEKLRIPFDV------RPP----------IGLFRLELLIWGVRQLQRI-EIISPKRH---------AVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYY---------------------VEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNK----AFDNKDEKGPEK------------------------TKAGVKSDAKPDVTNPVPGEPEKLIRFVPK-EEMESADWWTRYYAT---------------LGDLDDPNLYKPEDEILVESESEDEIRRDIF-------LGYRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLFQHKST---KELFLKEVQEHLIL-EDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPP-IDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIVDKITGG 6105
            MSL V ++ + G+    E  +K  FR    +T     + S     +  WP++R LD  D LV+    + +  P  L G + + L +L  +  + L E  VDE  R T + + FEI + SP      + + + + P   L   L+ + G  R      + ES  D  D     +    DGD  N S+    PE RD ++   I     K + +Q+ V + EAR L G NINP+  V  GK+ Q T  K  TN PFY+ YFSFD + +R +L+ + I+I+  + + H + R + PGKVIGEF  D +TVY  + H+ F KWAV++DPK P +G KG+VKVD+SV+  G +  R NK + ++D NIEAN+++P+ L  Q Q ++  +++ VYQAEDLP M+T I + ++QA +G+G A  DP VEV +AG+   TK      SP WNQ++IF   FPP    +R+ V+++  IK+E I+T  IDL  IM+       G+LP++GP+WINLYGTPR Y+YA+M++ +   N  L EGVA+RGRLL+AI T  + D+I ++G  +    PVS  VAGK+ +Y LFASIF+AT+I Q +G K KP++FE+S+G  G             P E++   +  E  +  +  S TEP    T D +Y+ + +  +KPC+YMI+  EDHR R+ IPNIL++L + L   + +  +   R +  +A ++ +  M      I  V+  ++ CRGTA +T LD+ + + IR  L+++ + +W ++   +    I   ++++N+ +K +   M  P   LPD+F+ MIQD  RV + R+ ARD+ +S +  EKG+  G + T++++K     + +K  + IQ QL +YLWLGLLKD   YK+G+P G    CF+   PP  + Y++ S F+LR Y+++ RNLI SD+SGLSDP  +V+I E++ ++   ++T SP+WD  ++   ++F ++PK +K     +V+E+FD D   + EF+GR FC  +V+I GD+Y    LQWW +YRG   AG++L +FDLI++D    R+   G P+   +   T                            +++ + + DEE   +  D       +PP          +GL   +L +    +  RI + I P            ++  + R  + PV +P++ IEIGG +I+S+I+ D      F ++     + LPV+ ++WPP+ +NC +   FG K +VG +  +++ +Y                      +  ++N  LD   D   +++ +   K  SD  +++      ++ +E  P +                        ++ G + D  PD  +   G PE ++   P  E++ SAD+WTRY+AT               L D D  +L +  D+I V  E  +E+  +I           +     + ++  +    +   + +K+++K+ +KKK ++ F  K T   K+++ KE  + LIL E  +  D SW+E+I IY   LE I+D+ GF  PFR+F LY+GKQ E++   E   R AG  KGN+ IY V +D        +    +++L  F                      K L     V   VRVYVV+ I LHPAD NG ADPY+++ +G   I ++++Y PKTLNP FG+ +E     P +S L +QV D+DR+  +DLIGET ID+ENR+ SPHR TCGLM+ YN HGY+KWKDS LPT IL+  C+K  I  P Y+ + + V + G+  ++ + I ++ G  +KS+EPLAL VL  +  +    +LV EH+ETR L   ++PG+ QG L++WVD+F     +PPP IDISPR+P  YELR++I  T +V L DT+ F+ E S DIY++ W+K   +D QKTD H+RSLSG+G FNWRF+F FDY+KAED I +K+K  ++++    K+ C L +Q+ D+D+  SD  +G +   LS  P+ AK  KSC   Q +  C +F+LFKN +VRGWWP         +E    LE+ G VE EM+L+   +AE++PAG  REEP  L KPNRPD SF   L P NT++YF KY+LKWILIKILI+ +F+LII LFIY FPG     IV KI G 
Sbjct:    1 MSLTVRVKYIDGLVGKGERVVKGNFRGSVQKTKRVLGRDSVYFDYQLTWPVSRPLDDRDKLVLSVYTVRKVPPWSLLGTVTVNLYSLNREPRLQLRENLVDENNRATSMIVAFEIAHQSPDGRVSGIDQQELSFPVTPLDYGLQAYPGDERSDPQIEAGESALDFEDEYTVLERMQGDGDVENLSDAFSGPEPRDPRITDRIGETIFKAQPYQLVVNVIEARRLFGTNINPVVTVTVGKEVQKTPAKFATNHPFYDSYFSFDLQRARQQLLTETIKIQVFNIRQHPMLR-LLPGKVIGEFVTDVRTVYDYKQHTIFNKWAVIVDPKDPWAGPKGYVKVDMSVVEQGQQMVR-NKREIDQDENIEANLILPRYLRGQKQDTMVSLAIQVYQAEDLPPMHTDISNKMRQAFVGEGAANVDPLVEVCYAGFKCQTKTKRYDASPIWNQELIFNNYFPPLTHAIRVNVKNAG-IKNEIIATHLIDLTTIMDLRTG---GYLPSFGPAWINLYGTPRIYTYAQMLRPEDELNLGLGEGVAYRGRLLMAI-TAKKDDTIERVGTAIEVATPVSETVAGKKNVYFLFASIFDATVIDQNLGSKNKPISFEISMGLFGNQLDGKRGGVDEIPIEFAKSAEGRERVD--WRKSTTEPMLPRTDDKEYYFLDFGPRKPCIYMISYFEDHRCRMCIPNILERLYEYLNYGLERFRFFTLRRQPHKARQWFRTLMRRLSKRITSVIQDVEGCRGTAMRTKLDIYHARRIRRDLKRIAVQAWKLS--SVQKHEIGEKVREVNAMLKRIVKLMQHPLDALPDIFISMIQDGRRVGFARVPARDIYYSVVESEKGKWNGQLATIFIRKQGREGVGEK-GWKIQCQLSVYLWLGLLKDFTAYKLGIPGGVDPMCFSRTKPPDELVYLQRSRFELRCYIFIARNLIASDESGLSDPLARVLIKEYVLQTQPLYQTMSPMWD-VLLHKQLLFYHDPKSMKENLQQLVVEVFDVDPGNELEFLGRCFCGINVWIEGDKYKPPGLQWWPLYRGQTDAGELLAAFDLIQLD---TRVPFEGIPTFAEIAAYTKDFDQRVILKSIPGMVLDDEDDLNRESTDEDYESDVDEEDELLDADSIIVAQHKPPRQKDRRRTVKLGLAPPQLAVRRREEDYRIPDSIRPPLQRFRFEVLFWSMFGMVRQQLLPVRRPKVTIEIGGTKIESEIMHDLRKRRLFENHFKVADVYLPVDERYWPPVVMNCHDNRTFGTKVIVGTYTFSNVRDYLDVSSLGLPEDDEDSMYDEGPNLAPRLNIRLDSLFDKEDAMSGRDQSKKRSDASASRRSEVTIEDSEESEPTEINLDDINPNFVAPKLEGSMDKRSLSETGEQRDP-PDYMDITAGGPEAVVHMGPTPEQLASADFWTRYFATINAADTYKEEEHHDELTDSDASSLSEKLDQIKVAEEPAEEVPMEILDPSATAQQKRKWWKKKKKQKRILTGREKRQLEIEKRRRKRVQKKKLRQKFAEKFTGDSKKMYYKEHYDDLILNEGTQGEDLSWVEKIMIYPTGLEEIEDFKGFVDPFRNFPLYKGKQTEDEASPE--SRLAGFLKGNLLIYAVNDDA-------EMPTQQTELKLF----------------------KTLPLKARVKLTVRVYVVRAIGLHPADRNGLADPYLILSLGKVVIDEKDDYKPKTLNPYFGKYYEFTAMLPVDSMLTIQVMDYDRVGSNDLIGETRIDIENRYHSPHRATCGLMNVYNTHGYVKWKDSLLPTEILERQCQKRGIEQPVYNLLENKVTVGGQDLHAITEITNESGGTVKSVEPLALEVLKRFSTLPSGIELVPEHVETRALVHPDRPGMSQGRLQLWVDIFDRSLGVPPPAIDISPRQPIQYELRVIIWNTADVILNDTSLFSSEMSSDIYVRGWVKGVGVDDQKTDIHYRSLSGEGNFNWRFIFPFDYIKAEDRIEFKDKGPFDVEPITIKSNCELTLQIWDADVFSSDNFLGGITMHLSAIPRCAKTPKSCGLHQLAPDCPRFSLFKNSQVRGWWPCA-------DEVFEKLEVQGKVECEMNLLTAVDAENSPAGRAREEPNALPKPNRPDSSFQRILGPLNTLRYFCKYKLKWILIKILIIFLFLLIIALFIYTFPG----AIVHKIVGA 2104          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDH-QFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVP------------SYNLTKLERHEGHIR----LPSDTSSVESDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKD----FQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIK-----------ALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPK-RPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT-------TSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTG------------------------------------------ICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGT--AKKTLLDVKYQKLIRMGLEKMKMSWSVTIECL--------------SVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIR---------------VAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKM-GLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGF-PSLENLMEMTAQVNDNSKGEKDE-------EKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDK--------------INEDLDHESDHLQSLTAQFDMK-----ANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTN-------------------------------------PVPGE------PEKLIRFVP-KEEMESADWWTRYYATLGDLDD---PNLYKPEDE-----ILVESESE-DEIRRDIFLGYRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLF-----QHKSTKELFLKEVQEHLILEDEKLS------DNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPP-IDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNI-YEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQ--HSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            M+LIV+L+SL G++   +  +KV FR + Q  +P   ++     G +F WP+ R +D+ DSL I+    ++   ++  GV+ I L  L     ++L E  +D     T++ L+ E+ Y SP S   +  + DF  P             +N  +     GH       P+D  ++ ++S +              D  S L    E    L      L  +++       +SVTI EAR LSG NINP  EV  G Q + T+ +M TN+P+YN+YF+F+FR ++ +LM+Q+I I+           A++K S +++R +F G +IGEF +D +TVYS     FF KWA LIDPK   SG KG+VK D++VL  G+K K +P KT   ++ +IEAN+L+P I    +R + ++SV +Y+AE LP MNT +M++IKQA+ GD K LADPYV+VSFAG++  TK I  SY+P WN+ IIFTE FPP  +R+RI++ D D + +E I+T FIDL +IMN++   E G LP +GPSW+NLYGTPR Y+Y  M    +  N+ + EGVA+RGRLL+AIKT              K G  V S   V   V G++E YLL   +F+A  I   IGKK K LTFELSIGT G                                          +     +   +K      Q+  S + P         Y+H+P+  +KPCLY+    EDHR R+ I NILD+L+                     A+R +  ++ T   ++  V      C GT    +T LD + +  +R+ LEK ++        L              S  ++   ++D  +  + + +   +PQH LPDVF++++  +                 +A+ R+ AR ++ +A   E G+ CG V T++L+K       Q + + +Q QL++ LWLG  ++        +P G+  D    + PP  + Y E +  + R Y++M RNLIGSD+SGLSD F +V+IG+ +  + V  E+ SP+WD T+ +  ++   N   V   PP VV+E+FD D+                                     + AG++L SF+L+++D   +    P F  SLE +   +A +   S G  D          L +P  VRP +  +R+E+L WGVR L R+++ S                V+ PRI +E GG R+ S+ IE     PNF  NL  + L LPVN  +WPP+   C +   FG   +VGNHV+  +++Y  +DK               + ++ +       LTA    K     +++ GV N +F  + E  PE         A P  T+                                      +PG       P+K  +  P +E++   DWW R+YA + +LDD   P      DE     I VE  SE D    D  +   VE    D++ +     +    +KK++K  KKKK+K+R F     + K  +  +L E  E    +DE+        DN W+ ++K+Y   LE ++D+GGF   F +F LYRGKQE  DD    + R  G+FKGN+C+Y + +           +  E  L S                     L+K L   + V  +VRVY+V+ ++LHPAD NGK+DPY+++R+GN  I ++ENYIPK LNP+FG+CFE+E  FPQ+S L + V DWD L+ DDLIGET IDLENR  S HR TCGL   Y+  GY +W+D QLP+ IL  LC +N + PPKY+     V + G+TF   S +ED+ G++ +S EPLAL VL+NW D V    LV EH+E+RPL+  EKPGIEQG +EMWVD+FP+    PPP +DISPR+P +YELR++I  T  V+L +T+  +     DI++K WMK   ID Q TD H+RSL+G+G FNWRF+FQF+YLKAED IVYK K+  + IDE E K PC L++QV D+D++ +D  +G L  RLS+ P+ AK  K+C  FQ          ++F+N++ RGWWP +   +DE  E+    E+GG V+ E+ L+   EAE+NPAGLGR EP PL +PNRP+ SF   L+P   +K+ I
Sbjct:    1 MALIVSLRSLDGLEGKSDRILKVTFRGNTQTTSPVASSRFQCYFGQQFQWPVGRPIDEADSLEIRAYNYSKILNNRQIGVLRISLQHLAETGSLDLREHLIDANNAPTNVILDCELRYYSPDSRIGDWQQDDFLYPVDGGVLKDGDGSDFNDDEALEAGGHAEDEADWPADARALLANSAD--------------DRLSSLQFEDEAASMLSDGASSLGNEMRKTLEVAAVSVTIVEARQLSGANINPCVEVRIGDQLKRTDTQMSTNSPYYNQYFAFEFRTTKADLMDQVIHIRSTRPTCCTESQAVNKGSMMISR-LFAGDLIGEFRLDVRTVYSAPDRMFFQKWACLIDPKDALSGPKGYVKCDINVLGKGEKLKVQPKKTKSSDEEDIEANLLLP-IGVPIKRQMADISVIIYRAEGLPKMNTDLMASIKQALAGDSKPLADPYVQVSFAGHSAKTKSIKNSYNPHWNEAIIFTELFPPLCNRIRISLFDWDAVYNECIATHFIDLGQIMNNS---ENGHLPIFGPSWVNLYGTPRNYNYENMFHPKEELNRGMGEGVAYRGRLLMAIKTEIKQAGGVGGGGGSKAGARVVSAAQVPEAVTGRKEDYLLAGILFDAGAIDANIGKKGKLLTFELSIGTHGNHVDGSFDDASDEDSADEASDFSDSAAGEDSDAELEGAQNRRLLAGGTAVAKEKLRGQRHQWCRSQSRPLMPLPAHEDYYHVPFMERKPCLYIRFGHEDHRQRMLIANILDRLRLH------------------DALRRLSGAIPTASTTVRAV------CHGTRAGPRTRLDQRRELAVRLALEKARVKSGALARQLRRHCAKAATNSSGGSASSLRGHLRDCRALARRIRELAEEPQHALPDVFVWLLAQDGGGGGGGQRQRRRQQQRLAFARLPARQVLQAAGEHETGRDCGRVITLFLRKPGRKGAGQ-SGWTLQCQLKLLLWLGPFREAATSLWPAVPAGYLGDPMRRRRPPSELVYGERTVLEFRAYVFMARNLIGSDESGLSDAFARVVIGDQVVSTHVIPESLSPVWDRTLSVTPLIIYLNEVDVLNHPPVVVVEVFDDDT------------------------------------ILNAGELLASFELVQLDANGR---TPDFVESLEQIRVASANIPRGSSGRGDHSDATVQSHHLPVPPSVRPQLAPYRIEVLFWGVRDLARVQLQS----------------VDSPRIEVEFGGRRVWSETIESCRLKPNFPRNLKCLDLMLPVNRWYWPPLMFQCEDSRQFGRTVLVGNHVVPSVLKYIRKDKSERRDKSGTVSSVAASNNIGNRKHWKDQLTAAKTAKTPTAVSSAAGVDNPSFIPEPETEPEVLAGHPAGTADPPGTSQAAQAALPAITAEAAGSEVGQSSEARTLDLAAENGQGTIPGTAMDLKLPQK--KLPPSREDLLEMDWWGRFYAAIDNLDDETDPESDSDTDEDILRDIDVEIRSEGDPAVEDNIVDIPVEEVKVDKKKQKKAEKKAKKLRKKRQKLLKKKKRKERRFRLPFGERKDARAAYLAEKHED---DDEQQGGRPHGEDNGWVSQMKLYHQPLEAVRDFGGFSHAFHTFPLYRGKQE--DDDAPPESRAVGIFKGNLCVYQISQAEF--------EAPEPTLPSL------------------FTLHKDLPSNNPVSVLVRVYIVRCVDLHPADPNGKSDPYLILRLGNTTINEKENYIPKQLNPVFGKCFELEAKFPQDSGLQLLVMDWDLLSGDDLIGETRIDLENRLYSRHRATCGLPIEYSTFGYNRWRDQQLPSTILARLCRENELDPPKYEPAYSRVTVDGRTFYEHSEVEDEAGNKTQSNEPLALKVLNNW-DQVTGVALVPEHVESRPLFSPEKPGIEQGRVEMWVDLFPTELGSPPPQVDISPRQPVAYELRVIIWDTAEVKLDETD-LSGASCSDIFVKGWMKGLGIDEQVTDVHYRSLTGEGNFNWRFIFQFEYLKAEDKIVYKVKDSPFAIDEEERKAPCQLHLQVWDADIVSADDFLGGLDLRLSRLPRGAKSAKACGAFQLERDSGVRAISIFRNRRCRGWWPFIGESEDEPGEQ----ELGGKVDAELQLLTAAEAEANPAGLGRSEPQPLPEPNRPETSFNFLLSPLKALKFLI 2045          

Query:  190 RFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMV--QQCIN--LDET------FVDEQMRITDIALNFE-IEYNSPVSGNENLGKSDFNVPSYNLTK----LERHEGHIRLPSDTSSVESDSDN----GDNEPSDDIDVKD------------------------------------GDNYSELSLLPERDFKLPKHIDPL-----SLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT--TSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPD-----EYSHLPKKEENFES-----QYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAK--KTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGF------HKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEI-DPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEK--LRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKG---PEKTKAGVKSDAKPDVTNPVP-GEPEKLIRFVPKEEMESADWWTRYYATLGDLDDPNLYKPEDEILVESESEDEIRRDIFLG--YRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLFQHKSTKELFLKEVQEHLILEDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQ---EEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKF-NLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKP 5913
            R+ WPI R LD  + L I+ +  NR  PDK+ G   + L  ++   + CI+  L+++        D+Q  + DI  N   +E +   S  E++G     VP  +L +    L     H RL    SS  ++  N    G   P       +                                    GD     S+  E D K    +D       ++K  DFQIS+TI EAR L+G N++P+  +  G QK+ T +K  TN P+YNEYF FDF +  + L E+II +          +R +   K +G F +D  TV+    H F++KWA+L+DP   T+G KG++K D+SV+  GD  K P  ++K+ED NIEAN+L+P  +    R      + +Y+A+ LP MN+ IM+N+K+A  G+   L DPYV+VSFAG TG T V    Y+P WN+Q++FTE FPP   R++I +RD+D +  + I T FIDL  I N     E+GFLPT+GPS+++LYG+ R YS   +I      N  L EGV++RGR+L+AI+T  T   D I   V++    P+S    GK E + LFA+I +A +I +++G K  P+ FE+S+G  G   D     +  H+  ++++ E+     +   S T P    T +  Y+ +PY   KPC+++ +   D+R R++I N ++K+ ++L + +++VN+L    +    +R +K+ +E   I   K ++  K  +  A   KT LD +  KL +  +E +          ++  ++    K  +S++  L   + DPQH +PD+FL+++    R AY RI+ARD++++ +  E+G+ CG V T++LK      LP K     T + IQA+LQI LWLGLLK  + +  G+P G+              +PP  I Y E+  FQLR ++Y  R+LIGSD SGLSDPF  VI GE  + + V  ET SP WDE +I D I+     + ++  PP V++EIFD D     EFIGR   +P V +RGD Y   K    L+W++V R    AG++L +F+L+E  D  SK   +P  P        T Q +D+   +  +    L +P  +RP +  +R+E+L WG+R L+R+ +++                V++PR+ I+  G+ + S II +   +PNF+  +  + L LP    + PP++I  ++   FG   +VG H I   I+ Y+            +  +S+ A          ++    D   EK    P++    +   ++     P P  + +K      + E E  DWWT+YY++ GD+        +D     S+++  +R DI       VE  S    D                            F+   T   F+ ++      + ++ S  S I     +  ELE I ++ GFK    +F LYRGK+   E EDD     +R  G FKG I IY     N         D ++  L  F                 N  L + L     +  +VRVYVVK + LHP D+NGKADPYI++++G K + D+ENY+ K LNP+FG+CFE E TFPQ+S L VQ++DWD ++ DD+IGET IDLENR+ S HR TCG+   Y   GY  W+D   PT IL  LC++  I PP Y   +  V  +    N D   E DD   ++  E +AL +LH W +    C L  EHIETR LY  EKPG+EQG +EMWVDMFP    +P PP +ISPRKP  YELR++I  T+ V L D  FFT EK  DIY+K W+K T+ D Q TD H+RSL+G+G FNWRFV+ FDYL AE  IV  K ++++  DE+E K P  L++QV D+D   +D  +G L   L+KFP+ AK  K C  +    +D      N+FK K+++GWWP      +E       LE+ G VE E+ L+  EEAE NP GLGR EP PL+KP
Sbjct:   33 RYDWPIGRPLDHNELLQIELVSQNRVLPDKIIGYYGLFLQRVISDGRLCISDYLNDSNHKTLPVNDDQQMLIDIEQNIANLERSLSTSQAESVGGGSIKVPRKSLLQRAISLNVSSSHERLDKRKSSALANVKNLIKIGKQRPPKSRTTSEESLLIYADEPGRVSRLSGADSAPISRAGSQASVTSMGDTLEYASIPVELDKKPRVKVDMATTVHSAMKALDFQISITIIEARQLTGLNMDPVVCIQIGDQKKFTSVKESTNCPYYNEYFVFDFHMPPIMLFEKIITLTVWQ------SRKLRSNKFVGSFKLDVATVWCQTDHQFYHKWALLMDPDDITAGPKGYLKCDISVIGKGDSIKVPQISEKDED-NIEANLLLPDGV-PVDRQHARFIIKIYRADGLPKMNSSIMANVKKAFTGELNDLVDPYVQVSFAGLTGQTSVKKNCYAPVWNEQLVFTEMFPPLCQRIKIQLRDNDPVNPKVIGTHFIDLKAISNDG---EKGFLPTFGPSFVHLYGSTRDYS---LIDEHSNLNIGLGEGVSYRGRILLAIRTELTENIDLIPSDVELDQIPPISETSYGKNEEFFLFATILDANMIEKKLGDK--PMYFEISVGNAGNAMDGQNLSKKEHVEIEKDDLEAVVTDLESWQSTTPPTKPMTHNKLYYFLPYWDNKPCMHIKSVWPDYRRRMYISNQIEKIAEKLDDGLQEVNHLIEMERSGSDLR-LKQVLEELMIGCQKYVTLAKDAQSGAGTGKTKLDKERMKLCQREIENIGTLARNLRAIVTKSSLKERYKTAHSYLATLQSLVDDPQHAVPDIFLWLVSGGKRQAYHRIIARDILYAIVDEERGKSCGKVQTIFLK------LPGKKAVGPTGWAIQAKLQISLWLGLLKQKKNFLNGVPNGYEITQEIRNADRPHALPPLTIHYTEKHVFQLRAHIYQARSLIGSDASGLSDPFATVIAGEFSKTTQVIDETVSPTWDELLIFDEILIYGTSEDIQQDPPFVIIEIFDQDKVGKSEFIGRTMAKPHVKLRGDAYWKPKFPPSLEWFDVKRSADRAGELLATFELLEYPDGDSKEEALPPTPE-------TKQASDSKDTDMKDLGPILPVPKGIRPTLCTYRIEVLFWGLRDLKRVHLMT----------------VDKPRVDIDCAGHTLYSPIIPNAKKNPNFSSPIKFLDLELPEQELYRPPLTIRAVDCRSFGRYTLVGTHTINS-IQKYIYVPRTRREREAEERKRSINAANQTNETHATLNTSTDDENKEKSPLLPKEPNGAISYGSRETTKKPKPETQKKKSEEDELEHEEEDRDWWTKYYSS-GDV-------VKDTRTPASKNQSLLRHDISPSDLEDVEVISSKSTDRKKFG-----------------------FKAVGTATRFVTKLSPKATGKPKRKSAFSRI-----FDMELEKIPEFNGFKDWLHTFELYRGKKSADESEDD-----NRIVGSFKGAITIYKWPLPN---------DFEDFHLTGF---------------DLNYGLLQGLPSNEQIRVLVRVYVVKALELHPMDLNGKADPYIVLQLGAKRVTDKENYVSKQLNPVFGKCFEFEATFPQDSLLTVQIFDWDLVSADDMIGETKIDLENRFYSRHRATCGIALKYEEDGYNAWRDPMKPTQILAKLCKEAKIDPPVYTPGHVKVGRITVPVNVD---EVDDLKIME--ERMALTILHKWHEFPIGCYLTPEHIETRSLYNPEKPGMEQGKIEMWVDMFPMDMPLPGPPTNISPRKPKGYELRVIIWNTDEVVLEDDAFFTGEKMSDIYVKGWVKGTE-DNQSTDIHYRSLTGEGNFNWRFVYNFDYLSAERRIVITKKESVFSWDESETKIPARLDLQVWDADHFSADDFLGALTLDLNKFPRGAKSAKLCTLEMITRNDGSVPMVNIFKQKRIKGWWPFYIKKDNEV------LELTGKVEAELHLLTQEEAEKNPVGLGRNEPEPLDKP 1922          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKT-KPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLG-----------KSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEPSDDIDVK--------DGDNYSELSL------LPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIK-----TTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH---------------------LPKKEENFESQ-----YVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEK---LRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            M+L+V L+++T ++   +   KV FR   F +   +  +        F WP+A K+D  + L I     ++   ++L G   +VL  ++ +  + + +T +D+       +++ EI Y  P+ G+  +            +  F   + +L     H   +   S  S + S  D+      +D+D K        D D  S  S+      +  +  K    ++P + +  D+QISVT+ EAR L G N++P+  V  G+ K+ T +K  TN P+YNEYF FDF +    + ++I+++  +  K+ + +     G ++G F +D  TVYS   H F++KWA+L DP   T+G KG++K D++V+  GD  K P+K ++ ++ +IE N+L+P+ +  ++R      V +Y+AE LP MNT IM+N+K+A +G+ + L DPYV+V FAG  G T V   SY P WN+QIIFTE FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ L EGV+FR RLLI++      TTS        V +   + +S +  GK E + LF S  EAT++ ++IG K  P+ FE++IG  G   D  S                      L +   + E++        S T P      D  YFH+PY  KKPC+Y+ +  +D R RL+  NI+DK+  +L E +  V  +  + +K    R ++  +E       + ++     +  A +T LD +  K     +E M          +   T+   +K   +F++ L     +PQH +PDVF++M+ +N R+AY RI  +D++ S +  E G+ CG V  V+L+      LP K       + +QA+L++YLWLGL K  + +  GLP GF      K      +PP  + Y  +  FQLR ++Y  R+L  +D SGLSDPF +V    H + + V  ET  P WD+ ++ DN+        ++  PP +V+EI+D D+    E+IGR F +P   +  + Y   +    L+++ +YRG   AG++L +F+L++I P + R  +P                    G  D ++   L +P  +RP +  +R+E+L WG+R L+RI +                  V++PR+ IE  G  I+S + +++  +PNF+  +    + LP N    PP++I  ++   FG   +VG+H +T L ++
Sbjct:    1 MALVVYLKTVTELRGKGDRIAKVSFRGLSFYSRVLENCEDEARFEEAFRWPVASKVDGNEMLEIHIYNYSKVFTNRLIGTFRMVLQKVVEEGHLEVSDTLIDDNNTAIQTSISIEIRYQ-PMDGSVRVWSDGEFLDVPEEREMFQFETESLLSSHSHICSVCATSVFSLIFSFLDDAAILEMEDLDRKAMRLGGGLDPDTISLASVTAVTTNVSNKRSKPDIKMEPSAGRPVDYQISVTVIEARQLVGLNMDPVVCVEIGEDKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKILKLSVIHSKNLLRS-----GTLVGTFKLDVGTVYSQPEHQFYHKWAMLSDPDDITAGCKGYIKCDIAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGV-PSERQWARFYVKIYRAEGLPKMNTSIMANVKKAFIGENRDLVDPYVQVQFAGQKGKTSVQKSSYEPIWNEQIIFTEMFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKIANDGDK---GFLPTMGPAWVNMYGSTRNYT---LMDEHQDLNEGLGEGVSFRARLLISVAVEILDTTSPEIMSSTEVQMEPVSNISESATGKLEEFFLFGSFLEATMVDRKIGDK--PINFEVTIGNYGNQLDGVSKPVSGKKKKREGGGESDEEESELIQNSSDEETEDDGDLVSVSSTPPMKPVITDRNYFHLPYFEKKPCIYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEII-KTEKAYPERRLRGVLEELSTGCSRFVTLANKDQNQAGRTKLDRERLKSCMREMESMGQQAKTIRSQVKRNTVRDKLKLALNFLQRLRFLADEPQHSIPDVFIWMMSNNKRIAYARIPTKDILFSIVDEEMGKDCGKVKAVFLR------LPGKKGFGPAGWTVQAKLEMYLWLGLNKQRKDFLSGLPNGFEENKAVKGTGLQAVPPISLTYNMKQVFQLRAHMYQARSLFAADTSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDNVELYGEATELRDDPPIIVIEIYDQDTVGKAEYIGRTFAKPLTKMVDEHYGPPRFPPQLEYYQIYRGNCTAGELLAAFELLQIGP-AGRTELPPI-----------------DGPTDVDRGPILPVPLGIRPVLSRYRIEVLFWGLRDLKRINLAQ----------------VDRPRVDIECAGKGIQSALNQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVTSLRKF 1212          

Query: 4240 IYSCELENIKDYGGFKQPFRSFSLYRGKQ-EEEDDGYEIQDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +Y+ ELE   ++  F+    +F+LYRGK  +++D      DR  G FKG++C+Y +   D I     FD +                             +  F S PH+  ++ +VRVYV++  +LHPADINGKADPY+++++G  EI+D+ENYI K LNP+FG+ F++E TFP ES L V VYDWD +  DDLIGET IDLENR+ S HR TCG+ S Y+ HGY  W+D Q PT IL  LC++  +  P Y      V++  + F   + IED++G + ++ E LAL  L +WE+I P   CKL+ EH+ETRPL   +KPGIEQG LEMWVDMFP     P P IDISPRKP  YELR++I  T+ V L D ++FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRFVF FDYL AE+ IV  K ++++  DE EYK P  L MQV D+D   +D  +G ++  L++FP+ AK  K C  D   +       ++FK K+V+GWWP V   +       + LE+ G VE E+ L+  EEAE +P GLGR EP PLEKPNRPD S + F+NP  +++YFI
Sbjct: 1285 VYNKELET--EFDHFEDWLHTFNLYRGKAIDDDDQNIVDDDRIVGRFKGSLCMYKLPLSDEITRDVGFDPN-----------------------------MGMFQSIPHNDPINVLVRVYVIRATDLHPADINGKADPYVVIKLGKSEIKDKENYISKQLNPVFGKSFDIEATFPMESMLTVSVYDWDLVGTDDLIGETKIDLENRYYSKHRATCGIASNYSLHGYNVWRDPQKPTQILAKLCKEGKLDGPHYGP-GGKVKVANRIFLGPTDIEDENGLKKQTEEHLALTALKHWEEI-PRVGCKLIPEHVETRPLLNPDKPGIEQGRLEMWVDMFPMDVPSPGPAIDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFDYLMAEEKIVISKKESLFSWDETEYKIPARLTMQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSIDMVLNEQELPTISIFKQKRVKGWWPFVARDE------NDDLELTGKVEAELHLMTAEEAEKSPVGLGRNEPDPLEKPNRPDTSLMWFMNPLKSLRYFI 1834          

Query:  646 IDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPDSI-KIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTG------------------ICPDEYSHLPKKEENFE----SQYVH-SLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH-----KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            I+P + +  DFQISVT+ E R L G N++P+  V  G +K+ T +K  TN P+YNEYF FDF +    + ++I+++  +  K+ + +     G V+G F +D  TVYS   H F++KWA+L DP   T+G KG+VK D++V+  GD  K P+K ++ ++ +IE N+L+P+ +   +R      + +Y+AE LP MNT IM+N+K+A +G+ K L DPYV+V FAG  G T V    Y P WN+QI+FTE+FPP   R+++ +RDSD + D  + T FIDL KI N  +K   GFLPT GP+W+N+YG+ R+Y+   ++   Q  N+ L EGV+FR RLL+++      TS P+ +    V V     +S+N AGK E + LF +  EAT+I ++IG   KP+ FE++IG  G                     DE S L +   + E     + V  S T P      D  YFH+PY  +KPC+Y+ +  +D R RL+  NI+D +  +L E +  V  +  + +K    R ++  +E         L      +  + KT LD +  K     LE M          +   T+    K    F++ L     +PQH +PD++++MI +  R+AY R+ ++D+++S +  E G+ CG V T++ K      LP K       + +QA+ ++YLWLGL +  + +  GLP GF      K       PP  + Y  +  FQLRV+LY  R+L  +D +GLSDPF +V    H + + + +ET  P WD+ ++ DN+        ++  PP +V+EI+D D+    +F+GR F +P   +  + Y   +    L+++ VYRG   AG++L +F+L++I P  K       P ++   +M        +G      L +P  +RP +  +R+E+L WG+R L+R+ +                  V++PR+ IE  G  I+S +I+++  +PNF+  +    + LP N    PP++I  ++   FG   +VG+H +T L ++
Sbjct:  162 IEPGAGRPMDFQISVTVIECRQLVGLNMDPVVCVEIGDEKKYTSMKESTNCPYYNEYFVFDFHLPPDVIFDKILKLSVIHSKNLLRS-----GTVVGTFKMDVGTVYSQADHQFYHKWAILCDPDDITAGCKGYVKCDIAVVAKGDNIKTPHKANETDEDDIEGNLLLPEGV-PAERQWARFYLKIYRAEGLPKMNTSIMANVKKAFIGENKDLIDPYVQVQFAGQKGKTSVQKSCYEPIWNEQIVFTEQFPPLCKRMKVQIRDSDKVNDVALGTHFIDLRKISNDGDK---GFLPTLGPAWVNMYGSTRSYT---LMDEYQDLNEGLGEGVSFRARLLVSLAVEILDTSSPEVMCSTEVQVEGVPNISDNAAGKIEEFFLFGAFLEATMIDRKIGD--KPINFEVTIGNYGSEVDDTPTKPKSKKSKKGDGDDEESELIQGSSDEEVTDDGELVSVSTTPPMKPVITDRNYFHLPYFERKPCIYIKSWWQDQRRRLYNANIIDNIADKLEEGLNDVQEIF-KTEKAFPERRLRGVLEDLSHGCSNFLELANKDQNQSGKTKLDRERLKSCMRELENMSQQAKTMRTQVKKKTVKDKFKQAQIFLQKLRFLADEPQHSVPDIYIWMISNGKRIAYARVPSKDILYSNVEEETGKDCGKVKTIFFK------LPGKKGFGPAGWTVQAKTEMYLWLGLNRQRKDFLSGLPNGFEENKAVKGPGMQSAPPISLIYTMKQIFQLRVHLYQARSLFAADSTGLSDPFARVFFSTHSQVTEILNETLCPTWDQLLVFDNVELYGEACELRDDPPIIVIEIYDQDTVGKADFMGRTFAKPITKMSDEHYGPPRFPPQLEYYQVYRGNCTAGEMLAAFELLQIGPGGK----ADLPPIDGPTDM-------DRG----PILPVPIGIRPVLSKYRIEVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGIQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVTSLRKF 1148          

Query: 4237 KIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDD-GYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            ++++ ELEN  ++  F+    +F+LYRGK  ++D+     +DR  G FKG++C+Y V   +    D+  E   +S +                          F + PH+  ++ +VRVYV++  +LHPADINGKADPYI +++G  EI+D+ENYI K LNP+FG+ F++E TFP +S L V VYDWD +  DDLIGET IDLENR+ + HR TCG+ ++Y  HGY  W+D   PT IL  LC+   + PP+Y      V++  + +   + IED++G + ++ E LAL VL++WED+ P   CKLV EH+ETRPL   +KPGIEQG +EMWVDMFP     P P +DISPRKP  +ELR++I  T+ V L D + FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRF++ FDYL AE+ IV  K ++++  DE EYK P  LN+QV D+D   +D  +G ++  L++FP+ AK  K C  D   +       N+FK K+++GWWP V   +       + LEI G VE E+ L+ GEEAE +P G GR EP PLEKPNRPD + L FL P   IK+ +
Sbjct: 1231 QVFNRELEN--EFEHFEDWLHTFNLYRGKSGDDDEQNASDEDRLIGKFKGSLCMYKVPMTD----DMGREMGIDSNMG------------------------MFQNIPHNDPINILVRVYVIRATDLHPADINGKADPYIAIKLGKTEIKDKENYISKQLNPVFGKSFDIEATFPMDSSLTVSVYDWDLVGTDDLIGETKIDLENRYYTKHRATCGITASYAIHGYNVWRDPMKPTHILAKLCKDGKLDPPQYGP-GGRVKVANRVYTGPTEIEDENGLKKQTDEHLALAVLNHWEDM-PRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPKDMPAPGPALDISPRKPKKFELRVIIWNTDEVVLEDDDIFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFIYPFDYLMAEEKIVISKKESMFSWDETEYKIPARLNIQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTIDMVLNEQEMPMVNIFKQKRIKGWWPFVARDE------NDELEITGKVEAELHLMTGEEAEKSPVGEGRNEPEPLEKPNRPDTTLLWFLMPLKAIKHLV 1781          

Query:  682 ISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNK-TDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIA----IKTTSQPDSIKIGVDVRSCNPVSNNVAGK---------------------------RELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVH---------------------SLTEPKYAYTFDNQ--YFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCE--YVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKM-KMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSK---MPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLI 3630
            IS+ I EAR L G+NI+P   +  G +K+ + +K  TN PFYNEYF FDF   +    +++I++  +  K       I     IG F ID  TVY+   H F  KWA LIDP   ++G KG +K D+ V   GD   R  K +D EE   IE N L+P+    + R      V VY+AE LP MN+ IM+N+ +A + D  AL DPYV VSF    G T     +  P WN+Q++F E FPP   RL+I V D   + D  I T +IDL +I N  + ++ GFLPT+GP+WIN+YG+ R    + ++  +Q  N+ + EGV++RGRL I     I T          + + S +      AGK                            E ++LF ++FEAT+I + IG K  P++FE +IG  G   D  +  P  ++  E  + H                     S T P+  +T      Y+++P  ++KPC+++    ED   RL   N+LD++        Y     ++AS  KKV+                D  L            T+LD K   L +  LE M +++ ++T     V TI   +++     + +   + +PQH LPD+F++M+ +N R+AY RI AR+L++S    EKG+ CG ++T++LK        +   + +QA++ +YLWLG   +       LPEGF     +S+     P+I+ Y +  +FQLR ++Y  R LI +D++GLSDPF +V    H   + + ++T +P W++ +++D +  +     +   PP + +E++D D+    E++G     P V +  + YT+  L +  ++ G++  GDIL +F+LIE+ P S +  +P +   E  +                    +P  +RP +  +R+E+L WG+R+L+++++++                V++P++ IE  G  + S +I+ + ++PNF+  + +  + LP +    PP++I  +++  FG   +VGNHVI +LI
Sbjct:   38 ISINITEARQLVGENIDPSVVIEIGDEKKQSSVKEGTNAPFYNEYFVFDFFAHQEIFFDKVIKLSVMHSK-------IMKSYCIGTFKIDVGTVYNQPGHQFTNKWAALIDPNDISTGVKGHLKCDICVTGKGDVSPRSQKFSDAEE--QIEKNPLVPEGF-PSMRPWARYYVKVYRAEGLPRMNSSIMANVTKAFVSDNTALIDPYVVVSFFSQVGRTSTQKSTADPVWNEQVVFKEMFPPLCRRLKIQVLDEGSMNDVAIGTHYIDLCRISNDQDGDK-GFLPTFGPAWINIYGSARN---STLVDDNQEMNEGIGEGVSYRGRLYIQLAVEILTGGAESKSMFSLKLPSKDAKGGKTAGKDPKAGTGGADTSFIVGNLVFVKVSEENMENFILFGAMFEATMIDRRIGDK--PISFEFTIGNCGNFIDGAAP-PAAKKRGERGFDHPGQEGAMTTPLLEGQAALSCKSTTRPEKPHTGHGNRVYYYLPISTQKPCIHVQCSWEDRTYRLHHSNMLDRIAFLFVSTAYYCGQEFIASVEKKVK----------------DNCL------------TMLDKKRLTLCKQELESMIEVAGTITEPKRKVLTIKEMLQESRKLTQKIRFLVEEPQHTLPDIFVWMLSNNKRLAYARIPARNLLYSENVVEKGKDCGKISTLFLKPPG----KRGATWAVQAKVDVYLWLGKCTESSNMLKNLPEGFEIHGVSSEESGGAPEIVLYKDHHEFQLRAHMYQARGLIAADNTGLSDPFARVSFQSHTHVTAIINQTLTPTWNQMLMMDKLSLHGMLTELAQEPPLITIEVYDDDALGKPEYLGSTVAVPVVKLAEEPYTAPSLHYSPLFCGSLSGGDILGAFELIEV-PKSGKHSLPPYDDPEGSI------------------YPVPSYIRPVLRKYRIEVLFWGLRELKKVQLLT----------------VDRPQVFIECAGKGVSSSVIQSYKSNPNFSMIVDAFEVELPEDEYLHPPLTITVVDWRAFGRSTLVGNHVINNLI 997          

Query: 4234 IKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVP-ECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAED-SIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIV 6087
            +KIY  ELE   ++G F    ++F LYRGK  EE+      +RF G FKG  C+Y +             D +E      G+   N+                 +    +V+ ++RVY+V   NLHPAD +GKADPYI++++G   I+DR+NYIPK LNP+FGR FE++ +FP+ES L + +YD+D +  DDLIGET IDLENR+ S HR  CG+ S Y   GY  W+D   PT +L  LC+ N +  P++      + I  K +   ++  D+D   ++S E LAL VLH WE++    CKLV EHIETR LY+++KPG++QG ++MWVD+FP     P PP+DISPRKP  YELRI+I  TE+V L DTNF T ++S DIY+K W+K  + D Q+TD H+ SL+G+G FNWRFVF F YL AE   +V K +NI+ +D+ E K P  L MQV D + L SD  +G ++  L  FP+ AK  K C      ++    ++F+ K+ +GWWP + +            E+ G VE E  LV  EEAE NP G  R+EP PLEKPNRPD +F  F+NP+    + I    K  +I  L++LI  L + L  Y  PG  S  IV
Sbjct: 1147 LKIYDKELE--AEFGPFDDWVKTFELYRGKANEEESSS--AERFVGNFKGRFCLYKL------------PDSEEYDCVDSGDYKINQG----------------IPPNTAVNVLIRVYIVSASNLHPADPDGKADPYIVLKLGKTVIKDRDNYIPKQLNPVFGRSFEIQASFPKESLLKILIYDYDVIGGDDLIGETQIDLENRFYSRHRAMCGIPSEYAIDGYNAWRDCIKPTDLLIKLCKDNRLDSPRFTP--GRITIGEKVYTGKTVFADED-QMVESYEHLALKVLHRWEEMPGVGCKLVPEHIETRALYIKDKPGLDQGQVQMWVDIFPMDMPHPGPPVDISPRKPKGYELRIIIWNTEDVILEDTNFITGQQSSDIYVKGWLKGLEDDGQETDVHYNSLTGEGNFNWRFVFPFHYLPAEKLVVVSKRENIFSLDKTEQKLPAVLVMQVWDFERLSSDDFLGSVELDLHGFPRGAKTAKDCKMEMLKESNDNISIFQQKRSKGWWPFIKSE-----------ELTGKVEAEFHLVTAEEAEKNPVGRARKEPEPLEKPNRPDTTFSWFVNPFKCFFHLIWKNYKKYIIIALLLLILALFLALLFYTLPGALSNKIV 1721          

Query: 4153 KELFLKEVQEHLILEDEKLS-DNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFN------SDSMIEDDDGSQ---IKSLEPLALVVLHNWEDI----VPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNK-NIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSD-ACAKFNLFKNKKVRGWWPLV----------------------------------YNPKXXXXXXXNG--LEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIV 6087
            KE+  KE  + +++E E  +     I  +K+Y  ELEN  ++  F     +F +Y+GK   ED+  +  DR  G +KG+  IY +  +   E++  D                                   +     +  + RVYVVK  NL PAD NGKADPY++V+IG +++  +E YIPK L+P+FG  FE+ V+FP E+ L + ++D D +  DD+IGET IDLENR+ S HR  CGL   Y+  GY KW+DS+ P+AIL  LC KN IP P+Y   +  V+++ K F        + +++ +  ++    +  E  AL VL  W ++    V  C LV EH+E R L   EKPG+ QG L MW+DMFP     PPP++I PR P SYELR++I  T++V L D N FT E S DIY+K W+K  D + Q+TD HF SL+G+G FNWRFVF FDYL  E  IVYK K +I+ ++E+E++    L +QV D D + S+  +G ++ RL+   + AK  + C      D A  +F++F++K+++GWWPL+                                    P+D    +  G    + G VE E  LV  EEAE NP G  R+EP PL+KPNRP  SF  F+NP  T  +FI  + K  +I ++I+ I  L + L +Y  P + S++IV
Sbjct: 1228 KEVKYKEEDDAVVVEIEPPAPKRKKISTLKLYKSELEN--EFSQFMDWLHTFPIYKGKANLEDEDDDDSDRIMGKYKGSFLIYPISSEEQEEEEDIDFQITRG-----------------------------IPKNSPIKVLTRVYVVKATNLAPADPNGKADPYVVVKIGQQQLDSKERYIPKQLHPVFGEVFELTVSFPLETELNIIIFDHDLVGSDDMIGETRIDLENRFYSRHRAGCGLALYYDKDGYNKWRDSRKPSAILADLCRKNGIPSPEY--RDTEVKVLNKIFKIPNEAFPEELLKKNKKTEEDYAEMDEHRALSVLQRWAEMREFTVGACPLVPEHVEVRSLLNPEKPGLPQGYLHMWIDMFPVDVPPPPPVNIKPRLPVSYELRVIIWNTDDVVLDDVNPFTGEPSSDIYVKGWIKGLDDEKQETDVHFNSLTGEGNFNWRFVFHFDYLPTEKEIVYKKKESIFSLEESEFRQHAVLVLQVWDYDRIGSNDFLGSIELRLNDMVRAAKSSELCSVKMAKDKASPRFSIFRSKRMKGWWPLIKLKSQEDIEREEREREMEKKNKKKKKKKQSKRGKMKPEDLQFVDSTGNTFLLMGKVEAEFQLVTAEEAEKNPVGKARKEPEPLDKPNRPKTSFNWFVNPMKTFVFFIWKKYKKYIIVLVILAILALFLFLILYTLPTHISQLIV 1891          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEPSD-DIDVK-----------------------DGDNYSELSL-------LPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKK--SHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDK---PKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGR--LLIAIKTTSQPD----------SIK-------------------------------------------IGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPD----------------------EYSHLPKKEENFESQYVHSLTEPKYAY--TFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFH--------KDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTV 2862
            MS+ V L+++  +    +  +++ FRD   +T   + +        F WP   K+ K + L I     +R   ++L G + + L  ++    + L E   D    +TDI +  ++ Y+            DF       TK+E  +    +  +T  +E     G+  P   D D +                       D  ++S+L +       +  R   L KH    + K+K FQ++V + EA+ L G NINP   +  G +K+ T  +  TN PFYNE F F+F+ ++  L +++I I  + KK  + ++TR       IG F ID  TVY    H F+ KWA + DPK   SG KG+VK  LSV+  GD       P  T + ED  IE N+L+P+ +   +R   +  + +Y+AEDLP MN   + +  + ++GD K   DPYV+V+FAG  G T V+S + +P+WN+QI F E+FPP   R+++ + D   + D  ++T F+DL +I   +N    GF PT+GPSW+NLYG+P+  +  ++    Q  N+ L++G+ +RGR  L ++++  S P           SIK                                           + V+V   +P+  N  G++E +LLFAS FE T+I   IG K   +TFELSIG  G   D                      E     ++EE        S+T P+ A    +D  +  I    +KPC+Y+    EDH  R    N L K+   L   + +V  L  R +     R ++  +E  F+S  K  S+    +  A+   LD      I+  +  +          ++  T+   + D+   +K +     +PQ  LPDVFL+M+    RVAY RI A  ++ S +  E+G+ CG V+T+Y+K       P      I A+L++Y+WLG+ K  +     LP  F                MPP  +   +   FQLR ++Y  R +I +DD+GLSDPF KV+     + + V
Sbjct:    1 MSITVYLKTIYNLPGKYDRKVELSFRDFTHKTKILQCENVAIFKENFRWPHYGKIQKDEVLTISVYNSSRMFSNRLLGKLVVSLQHVVTAGRLVLREPLTDSNYSLTDIYVELDVRYHPLQGAAGEWSGEDF-------TKVEDRDESGLVIKNTGFLEP----GNLRPQQLDRDARMLGRSLMKIDNEDGEDDDDDDYDDDYDFSDLEISSMTFTPILSRCRALSKHELAAAPKVKSFQVNVNVIEAQNLVGVNINPAVYITVGHEKKRTATQKSTNCPFYNENFMFEFQETQDVLFDKVIEISVVHKKTLAFLMTR-------IGTFKIDISTVYQQPDHRFYQKWAPITDPKDTRSGVKGYVKCTLSVMMKGDSMNMASLPPATSQNED--IERNLLLPKRMA-AERPWAKFLLKIYRAEDLPSMNAGFLGSFSK-MMGDKKVFIDPYVQVTFAGQQGETSVVSNTNAPEWNEQISFIEQFPPLARRIKVQILDDSNMGDVAVATHFLDLQQI---SNPNRNGFNPTFGPSWVNLYGSPQNSTLRDI---HQDLNEGLSDGIFYRGRVQLSLSVEIYSSPTTAVIENKSSLSIKSPLSKLTFKRKSRKSREKSKESAGAQAASGPAEESEASEVPEAVTVEVEEIHPLPENFVGEKEEFLLFASFFEVTMIDPSIGSKF--VTFELSIGNYGKTADVVVKSKKSGSREDLSEDRQGLLESDDELEREEPAAGPLDKSVTAPRRAQPTEYDGSFSCISLLREKPCIYVWNYFEDHTFRYHNCNWLSKMADRLEYGIDEVEMLLKRPRSNAKERLMEVLLE--FVSTCKQYSSSLDRKRQARPNPLDKHRSTFIKRNIIILAKQALRVRRRVTRRTVRDKLADVRRILKRIHFLTKEPQSTLPDVFLWMMSGGKRVAYARIPAHTVLFSLVEEERGKDCGKVSTIYMK------TPGGPLGEIFAKLEVYMWLGVTKYSKNCVTSLPAEFRPVYEGATFGTPLPPNMPPTKLAVEDSRYFQLRAHIYQARGIIAADDNGLSDPFTKVVFSTQCQVTQV 1021          

Query: 4228 ERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQI--KSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAED-SIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC-----DPFQHSDACAKFN----LFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEP---LPLEKPNRPDGSFLNFLNPWNTIKYFIKYR 5985
            + +K++  ELEN+ +Y G      +F LYRGK E+++D   +     G FKG+  +Y           L D+    S    F E                      L D    + +VR+YVV+GI+L P D NG  DPYI + +G K + DR+NYIP TLNP+FGR FE+    PQ+  L + VYD+D LT D+ +GET IDLENR LS     CGL  TY   G  +W+D   P+ IL+++     + PP+ +   +T+   G+ +       + +  Q    + E ++L VL           L+ EH+ETR LY   +P + QG L+MWVD+FP    +P PP DISPRK   Y LR+++  T NV L +T+  T E+  DIY+K WM   + D QKTD H+RSL G G FNWRF+++FDYL AE   +V K ++ + +D+ E+K P  L +Q+ D+D    D  +G ++  L     PAK  + C     +  + S +  KF+    LF  K VRGWWP       +        E+GG VEM +++V  +EAE  PAG GREEP     L  PNRP+ SF  F NP  T+K+ +  R
Sbjct: 1364 DTLKVFENELENVTEYKGLTDFCNTFKLYRGKTEDDEDDPTV----VGEFKGSFKVY----------PLSDDPAIPSPPRQFRE----------------------LPDSGPQECVVRIYVVRGIDLQPKDNNGLCDPYIKISLGKKIVDDRDNYIPNTLNPVFGRMFEVSCFLPQDKDLKISVYDFDLLTHDEKVGETVIDLENRLLSRFGSYCGLPQTYCTSGLNQWRDQLKPSQILQNVARLKGVSPPRSEDNGNTLAFNGQEYRLSDFEANKELHQHLGPATERISLHVLRT-------QGLIPEHVETRTLYSTFQPTLSQGCLQMWVDVFPKSLGLPGPPFDISPRKAKKYVLRVIVWNTTNVILDETS-ITGERMSDIYVKGWMPGKEEDKQKTDVHYRSLDGDGNFNWRFIYEFDYLPAEQLCLVSKKEHFWSLDKTEFKIPPQLIIQIWDNDKFSLDDYLGTVELDLHHLISPAKMPEKCNLKMLEQAKASKSPLKFDSSKSLFAQKSVRGWWPCYIEKDGKK-------ELGGKVEMTLEIVHEKEAEERPAGKGREEPNMNPKLNPPNRPETSFFWFTNPCKTMKFIVWRR 1914          

Query:  676 FQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHI-----VTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPN-IEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAI--LGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSD-MIKDETISTVFIDLHKIMNSANKEEE-------GFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVDVRSCNPVSNNVAGK---RELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEK-GQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGL 2637
            F+I V + E R L G NI P+ +V    +   T +K + N PF+NE  SF        LM  I     +  K  I      T  IFP        ID   +Y   +H    KW +L DP   + G KG++KV   ++  GD P    KTD++ D + +E+N+L+P  +     +   + + V++AED+P M+  I  ++K A    GD K L DP++E  FAG    TK+I  + +P+WNQ +    +FP    R+++ V D D + +++ + T +++L KI +S  + E        GFLP +GPS+INLYG+PR ++   +    +  N    EG A+RGR+LI + T       K   DV + +     VA K   R  Y L A    AT+I +      +P+ FE+SIG  G            + +   + + S T+   A    N Y+++P+   KP + +++  ED   RL   NI+  +   L   + ++         VQA     +  E +   + +VL  I  C         ++    ++     K+ +  S  I C++  T+ M                  PQ+ +PDV ++M++   RVAY+R+ A  +++S +  +  GQ CG   T+ L+      + +     + AQ+++ +WLGL
Sbjct:  138 FKIRVRVIEGRQLPGNNIKPVVKVNVCGETHRTRIK-RGNNPFFNEVISFYTIFLIPGLMYLIRNYAVIVNKVKIYIFICFTSFIFP-------QIDIGYIYDEPAHCVMRKWLLLNDPDDSSCGAKGYLKVSAFIVGTGDDPPV-EKTDRDTDSDDVESNLLLPAGIALRWVT---LQLKVFRAEDIPQMDDSISQSLKAAFGGTGDKKNLVDPFLEAWFAGKKICTKIIESNANPEWNQLVNLHVKFPSMCERIKLTVYDWDRLTRNDAVGTTYLNLTKIASSGGEVEAETGEPDVGFLPAFGPSYINLYGSPREFT--GLPDPYEDLNFGKGEGAAYRGRVLIELSTKLDG---KADTDVEAISNDDILVAQKYQRRRKYCLCAVFHSATMILE----PGEPIQFEVSIGNYG-----------NKLDSTCKPLASTTQYSCAVFDGNHYYYLPWADTKPVVAIMSFWEDISHRLDAVNIILNIANRLECNITELK------TAVQAKAPDLRLAEIWQKLVSQVLEDISRCFYFPTIHHTNLFLLNILNETALKLFLYVSYCIFCIT-WTLHM---------------FPQPQNSMPDVIIWMLRGEKRVAYSRVPAHQVLYSVLGEQACGQYCGKTQTIVLQYP----MDKNKGSKLPAQVRVNMWLGL 753          

Query: 2743 DFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            ++ LRVY+Y  RNL+  D    SDP+V V      + + +   + +P+WD+T+I + +    +P+ +   PP VVLEIFD D    +E +GR  C P V +     T  KL W  V     PAG++LVS +LI +   +    +P  P                  ++ +E   +P  VRP + L  +E+L WG+R ++  ++                 PV+ P +++E GG R++S +I++    PNF+ N++ + + LP    + PP+ +  I++  FG K VVG   I  L EY
Sbjct: 1042 EYHLRVYVYQARNLMALDKDSFSDPYVHVSFLHMSQTTEIIKASLNPMWDQTLIFNRVEIYGDPQTIARDPPQVVLEIFDSDQVGKDELLGRSTCPPLVKLDPGMDTPPKLLWRPVIHKGTPAGEVLVSAELI-LRNKTGETDLPLVPP-----------------KRGDELYMVPQGVRPVVQLTAIEILAWGLRNMKMYQLA----------------PVSSPSLVVECGGERVQSAVIKNIKKSPNFSGNVLQLKVLLPKEEMYTPPIVLKVIDHRPFGRKPVVGQCTINSLEEY 1305          

Query:  646 IDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT-----TSQPDSIKIGVDVRSCNPVSN-NVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHL--------------------------PKKEENFESQYVHSLTEPKYA-YTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKD-LNSFVKFLDDKMLDPQHGLPDVFLYMIQDNI-RVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGF-HKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            +DP + K + +Q+SV I EAR L G N++P+  V  G++K+ T  K  TN P+YNEYF FDF      + ++II++  +  K+ I +     G ++G F +D  TVYS   H F++KWAVL DP   T+G KG+V  D++V+  GD  K P+K+   +  +IE N+L+P+ +    R      V +Y+AE LP MNT I++N+K+A++G  + L DPYV+VSFAG  G T V   SY P WN+Q++FTE FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT+GP+W+N+YG+ R Y+   ++   Q  N  L EGV+FR RLL+ I       TS   S    + V S   V++ + +GK E + LF +  EAT+I ++I  K   ++FE+SIG  G   D  +                               +   +     S T P Y   T D QYFH+PY  +KPC+Y+ +   D R RL+  NI+DK+  +L E +  V     + ++    R ++ ++E   +   + L+          +T LD    K+    LE+M     +      + T   + +   +S ++     M  PQ  +PD+F++M+ +   RVAY RI A+D+++S +  E G+ CG V T++L+      LP K       + +QA+L+ YLWLGL K  + +  GLP GF  K    + +PP +++Y + S F+LR ++Y  R+L  +D +GLSDPF +VI   H + + VF ET  P WD+ +   ++     P+ ++  PP VV+E+FD D+    EFIGR   +P V I  + Y   +    L ++ +YRG + AG++L SF+L+++ P     + P            + +ND  +G      + +P  +RP +  +R+E+L WG+R L+R+++ S                V++PR+ IE  G  I+S +I D+  +PNF+  +    + LP N  F PP++I  ++   FG   +VG+  +T L ++
Sbjct:    8 VDPTAGKPQSYQVSVMIIEARQLVGLNMDPVVIVEVGEEKKQTSQKESTNCPYYNEYFVFDFHTPPNMMFDKIIKLSVIHSKNLIRS-----GTLVGTFKLDVGTVYSQPDHRFYHKWAVLTDPDDITAGIKGYVNCDIAVVGKGDNIKTPHKSVDNDADSIEGNLLLPEGI-PADRQWARFFVRIYKAEGLPKMNTAIVANVKKALMGQERDLVDPYVQVSFAGQKGKTSVQRSSYEPVWNEQVVFTELFPPLCRRMKLQIRDSDKVNDTAIGTHFIDLKKICNDGDK---GFLPTFGPAWVNMYGSTRNYT---LMDEHQELNDGLGEGVSFRARLLLGISMEILDITSPELSTNTEISVESIPHVADESCSGKMEEFFLFGAFLEATMIDRKISDKL--ISFEISIGNYGNSLDGLNKSNILDRSDDEDEYDEGDEDDETELLNDETDDAEMDDDTSGSSTTPSYKPETNDRQYFHMPYYEQKPCVYVRSAWHDQRRRLYNSNIIDKIADKLEEGISDV-LETMKMERPHPERRLRGALEEMSVGCSRFLTLANKDPSAFGRTRLDRDRLKICMRELEQMGPQAKLGRARTRIHTAPHSTRHTTSSTLRSTAALMAAPQDSIPDIFIWMLVNKTKRVAYARIPAKDILYSIVEEETGKDCGKVKTLFLR------LPGKRVFGSGGWTMQAKLEAYLWLGLNKQRKDFLTGLPSGFEEKKIGVTGVPPSVLNYHKRSQFELRAHMYQARSLFAADSTGLSDPFARVIFSTHCKSTEVFQETLCPTWDQLLQFQDVYMYGEPRELRDDPPMVVIEVFDQDTVGKAEFIGRALAKPVVKISTEPYEPPRFPPMLDYYQIYRGPVTAGELLASFELLQVPPADNCKFPP-----------VSGLNDTDRG----PIIPVPKGIRPVLAKYRIEVLFWGLRDLKRVQLQS----------------VDRPRVDIECAGKGIQSVVIADFNKNPNFSHLVKFFEVDLPENELFHPPLNIRVVDCRAFGRYILVGSQTVTSLRKF 997          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQ-EDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVP-ECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIVDKITGG 6105
            +E +K+Y  ELE   ++  F+    +F+LYRGK  +EDD  + ++R  G FKG+ C+Y     DN+ ++  +D        A FG                 +      +DP  ++ +VRVY+V+  +LHPADINGKADPYI++++G  E++D ENYI K LNPIFG+ F++E TFP ES L VQV DWD +  DDLIGET IDLE+R+ S HR TCG+   Y  HGY  W+D   PT IL  LC+ N +  P Y      V++  + FN  + +EDD G + ++ E LAL VLH+WE+I    CKLV EH+ETRPL   +K GIEQG LEMWVDMFP     P PP+DISPRKP SYELRI+I  T+ V L D  F T EK  DIY++ W+K    D Q TD H+ SL+G+G FNWRF++ FDYL AE+ IV  K ++++  DE EYK P  L +QV D+D   +D  +G ++  L++FP+ AK  K C  +  +   +    ++FK K+V+GWWP V   +++++      E+ G VE E+ L+  EEAE NPAGLGR EP PLEKPNRPD SF+ FLNP  +IKY I +R KWI+IK+++ L+ ++++ LFIYN PG     +V K+ G 
Sbjct: 1178 VEELKVYDKELE--AEFDNFEDWLHTFNLYRGKTSDEDDILD-EERVVGRFKGSTCVYKWPLADNVLKEVGYD--------AQFG-----------------MFQGIPTNDP--INVLVRVYIVRATDLHPADINGKADPYIVIKLGKTEVKDNENYISKQLNPIFGKSFDIEATFPMESMLTVQVMDWDLVGMDDLIGETKIDLESRYYSRHRATCGIAQQYAVHGYNTWRDPMKPTQILAKLCKDNKVDGPHYGP-GGRVKVANRIFNGPTEMEDDSGHKKQTEEHLALKVLHSWEEIARVGCKLVPEHVETRPLLHPDKTGIEQGRLEMWVDMFPKDMPHPGPPVDISPRKPKSYELRIIIWNTDEVILEDDAFMTGEKMSDIYVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFIYPFDYLVAEEKIVISKKESLFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKSSKQCTLNMLKMDGSVPMISIFKLKRVKGWWPFVSRDENDEQ------ELTGKVEAELHLLTAEEAEKNPAGLGRNEPDPLEKPNRPDTSFIWFLNPLKSIKYVICHRYKWIIIKLVVALLMLVLLGLFIYNMPG----YMVKKLLGA 1769          

Query:  511 SDTSSVESDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT-----TSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGIC--------PDEYSH------------------LPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKL-IRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNI-RVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYN-----IQAQLQIYLWLGLLKDMRLYKMGLPEGF-HKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEI 3147
            SD S   S S  GDN   D I +  G    E S +  +  K  + +DP + K + +Q+SV I  A+ L G NI+P+  +  G  K+ T ++  TN P YNEYF FDF  +   + + +I++  +  K  I +     G  IG F +D  TVYS   H F++KWA LIDP   T+  +G+V+ D++V+  GD  K+ +K+ + +D ++E N+++P   C+ +R      V +Y+A  LP MNT I++N+K+A++G  K L DPYV+VSFAG  G T V + SY P WN+Q++ T+ FPP   R+++ +RDSD + D  I + FIDL KI N+ +K   GF+PT+GP+W+N+YG+ R Y+   ++   Q  N  L EGV+FR RLL+ + T     TS   +    V V     ++++V GK E + LF +  EAT+I + I +K   ++FE+SIG  G          P E S                     K +   E   + S T P    T D QYFH+PY  +KPC+Y+ +   D R RL+  NI+DK+  +L E +  V   A +  K    R ++ ++E      ++  S       +   T LD K  K+ ++  +  ++ S+   +  L +  I+  ++ + + +  L   + DPQH +PDVF++M+ +   R+A+ RI A+D++++    E G+ CG V T++LK      LP K ++      +QA+L++YLWLG  K    +  G+P GF  K      +PP+++ Y + S F+LR ++Y  R+L  +D +GLSDPF +VI   H + + VF ET  P WD+ +   ++     P+ ++  PP VV+E++D ++    EFIGR   +P V I  + Y   +    L ++ +YRG + AG++L SF+L+++
Sbjct:  216 SDGSGGMSVSGKGDN--LDTISIASGK--VETSDVSNKRSKPEQRVDPTAGKPQSYQVSVMIIRAQKLVGLNIDPMVILEVGDAKKKTRIEKSTNCPNYNEYFVFDFNTAPNTMFDTMIKLTVVHNKDAIRS-----GTPIGTFKLDVGTVYSQPDHRFYHKWATLIDPDDITADVRGYVQCDITVVGKGDNIKKSHKSIESDDDSLEGNLILPD-GCKGERQWARFYVNIYKAVGLPKMNTAIVANVKKALMGQEKDLVDPYVQVSFAGQKGKTSVQNNSYEPVWNEQVVLTDIFPPLCRRMKLQIRDSDKVNDVAIGSHFIDLTKICNNGDK---GFMPTFGPAWVNMYGSTRNYT---LVDEHQELNDGLGEGVSFRARLLLQLTTELLDKTSPELNNTTEVMVEDIPRINDSVLGKMEEFFLFGAFMEATMIDRSISEKL--ISFEISIGNYGNSIDGLNKSNPQERSDDEDEDDDEDDEEETVLLTAQKAKGTDELSSMFSTTPPMKPETNDRQYFHMPYYEQKPCVYVESTWHDQRRRLYNSNIIDKIADKLDEGISDVKE-AMKTDKPHPERRLRGALEEMSSGCERFCSLANKDSSSIDCTDLDRKRLKMRLKELIYNIQHSFKTMLCMLFIQIINDMMRVMRNLLSALIACIKDPQHSIPDVFIWMLVNKTKRIAFARIPAKDILYANADEELGKDCGKVKTLFLK------LPGKRSFGPGGWAMQAKLEVYLWLGTNKQRNNFLNGMPTGFVEKKSIDPTVPPRVLTYSKRSQFELRAHMYQARSLFAADSTGLSDPFARVIFSTHCKSTEVFQETLCPTWDQLLEYQDVYMYGEPRELRDDPPMVVIEVYDQNTMGKSEFIGRALAKPVVKISTEPYEPPRFPPMLDYYQIYRGPLTAGELLASFELLQV 1112          

Query: 4237 KIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPG 6066
            K++  ELE   ++  F+    +FSLYRGK E++D   E +DR  G FKG++C+Y         ++L  E   + +   F                         +DP  +  +VRVYVV+  +LHPAD+NGKADPYI+V++G  E++D+ENYI K LNP+FG+ F++E  FP +S L V +YDWD +  DDLIGET IDLENR  S HR TCG+   Y+ HGY  W+D   P+ IL  LC++  + PP+Y      V++  +TF + + +ED++G +  + E +AL VLH+WE+I   CKL+ EHIETRPL   EKPGIEQG +EMWVDMFP+    P PPIDI+PRKP S E+R++I  T++V L D +  T EKS DI++++W+K    D Q TD H+ S++G+G FNWRFVF FDYL AE+ IV  K ++++  DE EYK P  L +QV D+D   +D  +G ++  L++FP+ AK  K C  D  +   +    ++FK K+++GWWP           E + LE+ G VE E+ L+  EEAE +PAGLGR EP PLEKPNRPD SF+ FL P  +IKY I +R KW+++KI++ L+ + ++ LF+YN PG
Sbjct:  407 KMFDKELEG--EFDNFEDWLHTFSLYRGKIEDDDSSME-EDRLVGRFKGSLCVYKYP----LPEELAREVGYDPQFGMFQGIPS--------------------NDP--IGVLVRVYVVRANDLHPADVNGKADPYIVVKLGKHEVKDKENYISKQLNPVFGKSFDIEAVFPMDSMLTVSIYDWDLVGTDDLIGETKIDLENRLYSKHRATCGISQRYSIHGYNMWRDPLKPSQILARLCKEVKVDPPQYSP-EGRVKVANRTFTAATEVEDENGQKKPTDEHMALTVLHHWEEIPGACKLIPEHIETRPLLHPEKPGIEQGRIEMWVDMFPADVPRPGPPIDIAPRKPKSLEMRVIIWNTDDVILEDDSLLTGEKSSDIFVRSWLKGQQEDKQDTDVHYNSVTGEGNFNWRFVFPFDYLVAEEKIVMSKKESVFSWDETEYKIPARLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTSKLCSLDMLKTDGSVPMISIFKQKRIKGWWPFAAR------NENDELELTGKVEAEIHLLTSEEAEKSPAGLGRNEPDPLEKPNRPDTSFMWFLTPLRSIKYLICHRYKWLIVKIVLALLLLAMLALFLYNMPG 984          

Query: 2668 LPEGFHK------DCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVP--GFPSLENLMEMTAQVN-DNSKGEKDEEK---LRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAG-VKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDLD 3930
            LP G+ +            +PP  + Y E+  FQLRV++Y  R+L  +D +GLSDPF ++I   H + + V  ET  P WD+ ++ D+I      + ++  PP +V+E+FD D+    +FIGR   +P V +  ++Y + +    L ++ +YRG   AG++L +F+L+++       + P    P    L+  + + +     G  D E    L +P  +RP +  +R+E+L WG+R L+RI++++                V++PR+ +E  G  ++S +I  +  +PNF+       + LP N    PP++I  ++   FG   +VG H +T L                         +F ++A S   +       D   P    +G V     P VT   P      I   P EE+   DWW++Y+ ++  L+
Sbjct:    1 LPNGYEQKKAKNSSPIAQALPPISLIYKEKQMFQLRVHMYQARSLFAADSTGLSDPFGRIIFSTHSQATEVIPETLCPTWDQMLVFDSIELYGEAQELRDDPPIIVIEVFDQDTVGKADFIGRALAKPVVKMSNEKYDAPRFPPQLDYYQIYRGNSTAGELLAAFELLQVATSPTHHHAPRTTAPRPATLIPPSGKGDLPPISGPTDTEHGTILPVPRGIRPILSKYRIEVLFWGLRDLKRIQLVT----------------VDRPRVDVECSGKSVQSVVIPSYKQNPNFSTLFKHFEVDLPDNELLHPPLNIRVVDCRAFGRYTLVGTHTVTSL------------------------RKFILRAPSKTKAANIRTIGDPNDPRLPASGSVCQSVCPQVTAHQP------IIHQPDEEL--LDWWSKYFVSIETLN 390          

Query:  655 LSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILG---DGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSD-MIKDETISTVFIDLHKIMNSANKEEE---------------------GFLPTYGPSWINLYGTPRTYS-----YAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVD-VRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTG-----ICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDN-QYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVL----SAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEK-GQMCGMVNTVYLKKMNFSILPQKTN-YNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSD 2814
            +S K +DFQ+ + + EAR L G NI P+ +V    Q + T ++ + N PF++E F F+F +S  EL +++I  K L   S      +     IG F +D  TVY    H+F  KW +L DP+  +SG KG++KV L VL AGD+P        EE  +IE N+L P            +++  Y+AED+P M+  ++  +KQ I G   + K L DPY+EVSFAG T  TK+I ++ +P+WNQ I    RFP    RLRI + D D +  ++ + T F+ + +I      E E                     GFLPT+GP +INLYG+PR ++     Y E+       N    EGVA+RGR+L+ + TT   D I   V+ + S + +      +R  Y L A+ + AT++ +E+    +P+ FE+SIG  G      CP   S          +QY  ++        FD    +++P+ + KP + + +  ED   RL   NIL   ++ L     +VN    R   +QA   ++    ++  +ID ++     A+         T LD +  +     L  +  S     E      ++  + +L+ +++ L +   +PQ+ +PDV ++M++ + RVA+ RI A +++HS++ P   G+ CG+  T+ LK       PQ T+ + I  Q+++ +WL L  D +              F      K+  + E  + Q R+ L  G    G      SD
Sbjct:  204 VSRKPRDFQVRIRVIEARQLPGNNIKPVVKVTVAGQSKRTRIR-KGNNPFFDETFFFNFHLSSAELFDELIYFKVLHSHS------LRADSEIGTFKLDVGTVYDEPRHTFQRKWLLLCDPEDLSSGAKGYLKVTLLVLGAGDEPPEDRSEAVEEREDIENNLLRP---AGVSLRGAFLTLRAYRAEDVPQMDDAVLDTVKQ-IFGFDSNKKNLVDPYLEVSFAGKTLCTKIIEKNANPEWNQAISLPIRFPSMCERLRITLYDWDRLTHNDAVGTAFLSMSQISCPGGDEPEAFITMRCLRLNLLRLIEDEGTGFLPTFGPCFINLYGSPREFTGFPDPYEEL-------NFGKGEGVAYRGRILVEL-TTKLEDHINNKVEPIPSDDLLRVEKYLRRRRYNLCATFYSATML-REVN---EPIQFEVSIGNYGNKYDVTCPPLAS---------TTQYSRAV--------FDGCSSYYLPWGNIKPVVTLTSYWEDVGHRLEALNILMHTQRRL-----EVNIGRVRA-TLQAREPVEAVAVSWLHAIDTLIEDCSQALPEITERPNVTPLDREVWRARSATLALILRSAQRLRE--EATRVEETLSELDDWLERLTELTREPQNSIPDVVVWMLRGDRRVAFARIPAHEVMHSSLGPHACGKNCGITQTIVLK------YPQDTHGFKIPGQVRVRIWLSLAADSK-------------SFNETSEGKLAVFAETYENQTRLALVGGWGTTGLTRHKFSD 899          

Query: 4900 GYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTF-NSDSMIEDDDGSQIKSL-EPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQ-GLLEMWVDMFPSGTAIP-PPIDISPRKPAS-YELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAED-SIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAK-----FNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEP---LPLEKPNRPDGSFLNFLNPWNTIKYFIKYR 5985
            G  +W+D   P+ IL+ +    + P P Y+   D + + G+ +  SD   +      +  + E LAL +L +         L+ EH+ETR L    +PG+EQ G L MWVD+FP     P PP DI+PRK    Y+LR +I  T++V L +T+  T EK  DIY+K W+   D   QKTD H+RSL G+G FNWR++F F+Y+ AE+  +V + ++ + +D+ E + P    +Q+ D+D    D  +G L   LS  P PAK  + C          K      +LF+ K V+GWWP +     +         I G VEM ++++  +EAE  PAGLGREEP     L+ PNRP+ SFL F +P  T KY I  R
Sbjct:    2 GQNQWRDQMTPSMILEGVARAKSWPQPIYE--GDRLTLKGRDYLMSDFEAKAPTNPHLGPVKERLALHLLRS-------MGLIPEHVETRTLEHSIQPGLEQQGKLMMWVDVFPKNMGPPGPPFDITPRKAKKRYQLRCIIWNTKDVILDETSI-TGEKMSDIYVKGWIDGRDDAKQKTDVHYRSLGGEGNFNWRYIFPFEYVPAENICVVSRKEHFWSLDKTELRLPPKFTIQIWDNDKFSPDDYLGYLDLNLSHMPVPAKSAEKCSLEMVETPTGKKKHKTTSLFEQKNVKGWWPCIAEEDGKKI-------IAGKVEMTLEILADKEAEERPAGLGREEPNMNPKLDPPNRPETSFLWFTSPLKTFKYIIWRR 360          

Query:  682 ISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPK----APTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIG---VDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGIC-----PDEYSHLPKKEENFESQ------------------YVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNIL----DKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAK--KTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKD----LNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKM---PPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTS----SKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYY-VEDKINEDLDHESDHL---QSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKL---------------IRFVPKEEMESADWWTRYYATLGD 3924
            I + I+EAR L+G  I+P+  V  G QK+ T +K QTN PFY+E+F FDF++  + L ++I+  +  + ++ +       G +IG F +D  TVY+   H F  +WAVL DP+    A  +G KG+ +VD++VL  GD P +     K+ D +IE N+L+P  +   +R    + + +Y+AE LP MN+ +M+N+K+A  G+ + L +PYVEV FAG+   T V   +Y P WN+Q++F+E FPP   R++I ++DSD + DE I T FIDL +I N       GF+PT+GP W NLYG+ R YS   +       N  L EGVAFRGRLLIA+       + + G   V+V    P+S+  AGK E + LFA  +EA++I +++G K   ++FE+SIG  G        DE SH    +    +Q                  +++SLT P    T D QY+HIP+   KPC ++    +DHR RL+  N+L    ++L+  L + + +V             R++ + +       ++ L+ IKS    +   +T LD +  KL +  +E +  S     E  +    D  +KD     N+ ++ L +  ++PQ  +PDVF++M+    RVAY+RI ++ +++S +  E+G+  G + TV+L+      LP K       + IQA+L I +WLGL K  + Y    P+G+       K+   PP  + Y E+  F LR ++Y  R+LIGSD SGLSD F +VI    +  + V  ETRSP WD+T+I   +V   +   +   PP +V+EIFD D   D EFIGR   RP V +  + Y        L+W+ V RG   AG++L +F+L+++   S   ++P              VN       D     +P  +RP +   R+E+L WGVR+++RI + +                V++P++ I++ G+ I+S +I +   +PNF + +    + LP N ++ PP++I   +   FG   +VG HV+  L  Y    +K  E ++         + L A    +  S G    A +  D    E  +  +++    D   P+      +                +    ++ +S DWW+RYY TL D
Sbjct:  262 IQIRIHEARQLAGTQIDPVCTVSVGNQKKSTTIKEQTNCPFYDEFFVFDFKMPPMVLFDKIVMFQFYTGRNLVSQ-----GALIGSFKLDVGTVYAQPDHRFCRRWAVLTDPEETLGASGAGVKGYARVDITVLGKGD-PAKEQPGIKDNDDDIEGNLLLPDGV-PAERPKARVIIKIYRAEGLPKMNSGLMANVKKAFTGEVRDLVNPYVEVQFAGHRARTTVKKNTYEPKWNEQVVFSELFPPLCRRIKIQLKDSDSVTDEVIGTHFIDLSRISNDG---ANGFMPTFGPCWANLYGSTRDYS---LFDEHNDLNNGLGEGVAFRGRLLIAVHAEFGESASESGIRQVEVEPTAPISDTAAGKDEQFQLFACFYEASMIDRKVGDKM--VSFEMSIGNWGNSIDGQPIDEVSHATHIQHTSNTQHTQSTMGGDEDRRDGDNPFLYSLTPPVKPVTNDRQYYHIPWEDSKPCTHIKFMWQDHRRRLYNSNVLLKICERLEDGLTDCIERVKM-----DLPNTFRWLSRVLSELINGCNQYLNLIKSMPTASHVGRTKLDKERLKLCQYEVESVCTS---AQELKTSTKDDTHMKDNLKAANALLQRLLNIAVEPQDTIPDVFIWMLCGGKRVAYSRIPSQHIMYSLVEEERGKDSGRMQTVFLR------LPGKRGDGPKGWAIQAKLNIMIWLGLHKHKKDYLKDAPKGYQTPKNAHKLMAPPPNHLIYTEKQKFVLRAHVYQARSLIGSDASGLSDAFARVIFTHLVSDTRVIWETRSPTWDQTLIFQEVVLWGDVNEIAVNPPTIVVEIFDKDIGGDSEFIGRALARPIVKMACEPYEKPFFPPALEWFQVCRGEENAGEMLAAFELLQVT--SGTCFLP---------SEVEPVN-----TPDGPITPVPVGIRPVMKKHRIEVLFWGVREMKRINLTT----------------VDRPQVDIDLAGHVIQSTVITNAKKNPNFQNPVCYFDVELPENERYCPPLTIRVRDCRTFGRFTLVGTHVLNSLHRYLQTGEKEKERIEKAGKSCLDRKRLLANGPSRPTSPGGGEVALEMDDAPPIEMEQMELQARLITDTETPIAVVATDMHASTDHEKKKEKGDKDKKEDDDDEDSLDWWSRYYETLKD 1352          

Query: 4234 IKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNK-NIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +KI+  ELE + D+ GF     SF L+RGK+  EDD  +   R  G FKG++ ++                     L    E D                   FL  P +  V+ +VRVYVVK +NLHP+D+NGKADPY++V +G   +RDR+NY+ K LNP FGRCFE E   P +S L V +YDWD +  DDLIGET +DLENR+ S HR TCGL   Y   G+ KW+D   PT IL  LC++  +  P Y      V +  K F +   I ++ G   +S EP AL  L  ++ +     LV EH+ETR L+  EKPG+EQG LEMWVDMFP     P  P+DI+PRKP SYELR++I  TE+V L + N  T EK  DI++K W++    D Q+TD H+RSL+G+G FNWRF+F F Y KAE+ IV   K + +  DE+E K P  L++QV D+D   +D  IG L   L++ P+ AK  KSC  D  +   +  + + FK K ++G+WP   N ++E+      +E+ G VE E++L+  EEAE  PAG  RE+P  LEKPNRPD +++  +NP   +K  I
Sbjct: 1402 MKIFKLELECMHDFNGFNDWLHSFPLFRGKKTSEDD--DDDHRIVGKFKGSLKVWKY------------------PLPEHVEMDPIVGT--------------FLKLPSNEPVNVLVRVYVVKALNLHPSDVNGKADPYLVVNLGKHRVRDRDNYVSKQLNPTFGRCFEFEAIIPMDSMLTVGIYDWDLVGSDDLIGETKVDLENRFYSRHRATCGLQDQYATFGFNKWRDPLRPTQILAKLCKEEGLDGPHYS--TGRVRVDNKVFVAAPQILEESGHWKQSDEPSALRCLKQFQTLKRGFTLVPEHVETRALFNPEKPGVEQGKLEMWVDMFPMDMPSPGAPVDITPRKPTSYELRVIIWNTEDVLLEEANMLTGEKCSDIFIKGWLEGLKDDKQQTDVHYRSLTGEGNFNWRFIFPFQYQKAEERIVITRKASFFSWDESEEKVPARLHLQVWDADAFSADDFIGDLCLDLTRMPRGAKTSKSCTLDLLKQDGSVPQVSFFKMKHMKGFWPFFVNTEEEE------IELAGKVEAELELLTQEEAEKKPAGRAREDPQALEKPNRPDVAWMMMMNPLRGLKAMI 1946          

Query: 4237 KIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKY----DKMNDTVEIMGKTFNSD--SMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAI-PPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNK-NIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKF-NLFKNKKVRGWWPLVYNPKXXXXXXXNGL-EIGGTVEMEMDLVLGEEAESNPAGLGREEP---LPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +  S ELE I+++GG +    SFSLYRGK ++ DD  E   +  G FKG   IY      + E +  D D  E+   +                         L     +D +VRVY++  I+L P D  G ADPY++V++G K++ +++ Y P TLNPIFG+ FE++   P    L + + D+D LT+DD+IGET IDLE R L+ +R  CG+  TY + G  +W+D + P  +L+  CE+       Y    D   D + +  + +  D      + +       + LAL VL+  E        + EH+ETR L    +P IEQG +++WVD+FP    +  P +DI+ R+P +YELR+++  T  V + +T+  T E+  DIY+K W++    D +KTD H+RSL G G FNWR VF F YL  E  +V + K + + +D  E +    LNMQ+ D+D    D  +G  +  L K PKP +  K C   +      ++ +LF+   ++GWW             + G+ E  G +EM ++++   EA   PAG GR+EP     L++PNRP  SFL F +P+ T+KY I
Sbjct: 1279 RTLSPELEKIEEFGGLEDMIASFSLYRGKAKKRDDDDEETQKVVGEFKGTFRIYP-----LPEAEGVDPDLPETVFTN-------------------------LPPNEPIDCVVRVYILSAIDLQPQDPGGLADPYVVVQLGKKKLDNKDQYKPNTLNPIFGKMFELDAVIPVHKDLKITLMDYDLLTRDDMIGETVIDLEQRLLTRYRAKCGIPKTYCDSGPNQWRDHKRPMELLREWCEETEKNFKFYKGTKDGTPDRIVVGYRVYQLDEFGAFRNPNEHLGAKHQRLALHVLNQLE-------FIPEHVETRGLRSPMQPNIEQGKVQLWVDIFPKNEGVLKPSVDITAREPTNYELRVIVWNTSGVIMDETS-ITGEQMSDIYVKGWLEGMGDDKEKTDVHYRSLDGDGNFNWRMVFNFLYLPIEKKMVIREKEHFWSLDAKEVRLAPRLNMQIWDNDTFSYDDFLGSCQLDLIKLPKPCQTAKRCGTSRDPGKNGEYVDLFQQHSIQGWWACY----------QEGIEEPTGKIEMTIEVLNSNEAAVKPAGKGRDEPNQNPHLDEPNRPATSFLWFTSPFKTLKYII 1823          

Query:  658 SLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKP----KRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIK---QAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMI-KDETISTVFIDLHKIMNSANKEEE----------GFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVD-VRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECL-----SVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLG 2634
            S K++DFQI V I E R LSG NI+P+  V    QK+ T++   TN P YNE F+F+F  S  EL + +    A+S  S+     I P K + +     K  Y +   SF +   V +         +G++KV   VL  GD+P    K P K + E+D  IE+N L+P  +    R     ++ ++QAED+P M++ +  +IK   + I G  K L DPYV+V+F G    T +  +  +P++ +Q+     FP    R++I + D D +  D+ I T F+ L  I    ++  E           F PT+GP ++N YG+PR +S  E+   D   N+ + EGVA+RGR+LI ++TT   + I+  V  + + + V      +RE Y LFA  +EAT+I    G    P+ FE+SIG  G   DE                 + T P         Y ++P+ ++KP + + +  ED   RL   N++ +L  +L   V++V          +   ++        + I   +  +     ++K    D+  +K++ +      ++ +  ++       +   ++  + +LN +++ L D  ++PQ+ +PDV ++MI  + R+AY RI A++++ S  P   G++CG    + LK         K +  I A +++ LW G
Sbjct:    5 SDKVQDFQIRVKILEGRQLSGNNIHPVVRVAMSNQKRETKIVRSTNKPVYNESFTFNFHTSEAELFDDLFS-PAVSAHSYW-RWGIRPKKQLFQGLPRPKCAYIS---SFAFLNVVFL--------FQGYLKVTAMVLGPGDEPPIKAKLPPKEEDEDD--IESNCLMPMGVA---RQPALFNLRIFQAEDIPQMDSGMGRSIKKFFKGIFGGAKGLVDPYVKVNFCGKKIETSIKYQDDNPEFKEQVKIPLMFPSMCERIKIQLYDWDRVGNDDCIGTAFLSLSSISGQGDEGNELLVILHPSLLCFPPTFGPCFVNFYGSPREFS--ELPDQDDALNKGIGEGVAYRGRVLIELETTLGSNEIEQEVSQIETEDIVRVQPFLRREKYKLFACFYEATMIKDVDG----PVEFEVSIGNYGNKMDE-------------SVAPANTAPSNPLFDGCHYNYLPWGNEKPVVVVESFWEDIAFRLEPLNLISRLCDKLEVNVKRVRSALDAPTPPKEDAFVPMVTSILEVLISDCIPHVGVLSKSSKHCSYDILGRKVLPLNHRDHDLNLTTELKSALDFPGAEINMEQTVGELNGYLQRLRDVAIEPQNCIPDVIVWMISGSERIAYYRIPAQEVLFSTTPDACGKICGKTVELRLKYPGKKGQDLKDHPEIPALVRVELWFG 650          

Query: 2629 LGLLKDMRLYKMGLPEGFHK-DCFTSKMPP--------------------KIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENL-MEMTAQVN-DNSKGEKDEEKLRIPF--DVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLI-SVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDLDD 3933
            +  ++  R+ +  +PEG  K D   SK+PP                    K +       FQ+  Y+Y  R+L+  D+SG++DP+V+V      + + V  +T  P WD+T+I    +F+    I +  PP VV+E+FD D    ++F+GR   +P   I G+E  + KL W+ +  G    G+IL + +L  +     +        L N  ++    VN  +    +D E   +P    +RP +    +E+L WGVR +++ ++ S                +  P +  EIGG  I+SDI+ D    PNF   ++   I+ LPV   + PPM+I   +   FG K  V  H I  L  +                                           +    T AG      P      PG+P + +  VP+ E    DWW++YYA+L   +D
Sbjct:  872 MDFVRRRRMMRKLIPEGGGKIDPKKSKLPPILRNKAKGITFFRTPSLSISKSVISCTPHKFQMWAYVYQARDLLAKDESGMNDPYVRVAFANQSQMTEVKQKTLCPTWDQTLIFHVDLFDSLENIQRN-PPTVVMELFDKDQVGKDDFLGRTEFKPYPRIHGNEGPACKLLWYPISHGDEDGGEILAACELFLVSFIFFQCTTKLETGLLNFHLQDDGVVNIPHPPTPRDAEGEILPVRDRIRPVLQKTVVEVLCWGVRNMKKYQLAS----------------IKSPSVQFEIGGEIIQSDILTDAKKFPNFGRPILPRKIINLPVEEMYTPPMNIRIHDNRTFGRKPTVAVHSIKSLTRF-------------------------------------------RCAAPTPAGQIQVEGP----AAPGQPAEGV--VPEAESHKFDWWSKYYASLNQTED 1266          

Query: 4573 IVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMND---TVEIMGKTFNSDSMIEDDDGSQIKSLE------PLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFP-SGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC----DPFQHSDACAKF-NLF--KNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEP 5895
            IVRVY++ G++L   D +G  DPY++V IG KE   R++Y  KTLNP+FG  FE   + P    L + V D+DRL++DDLIGETTIDLE R LS +  TCGL  TY   G   W+DS+ P  IL+ +C    +  P +    D   TV +    FN    IED D  Q++S E       L+L  LH          +V EH+ETRPLY   +P IEQG L++WVD+FP +  +I PPI+I PRKP  + LR++I  T +V L +T+  T EK  DIYLK W++  D  L KTD H+RSLSG G FNWR  F F +L  E  +    K ++   E E K    L +Q+ ++D    D  +G     L + PKP    + C    DP    +    F +LF      +RGWW    +     + +       G V+M ++++  EEA++ P GLGR EP
Sbjct:  487 IVRVYIICGMDLQSQDTDGFGDPYLVVSIGKKEFSTRKDYKKKTLNPVFGEMFEFHASIPSSKDLKITVMDYDRLSRDDLIGETTIDLEQRLLSGYHATCGLPKTYFKSGPYAWRDSKTPKEILREVCLDRGLNRPDFYHKGDQAVTVVVGEDQFN----IEDLDDYQLESNELGSSEQRLSLHALH-------AMGMVPEHVETRPLYSPLQPRIEQGKLQLWVDIFPCTEGSIKPPIEIEPRKPKDFVLRVIIWDTTDVELQETS-ITGEKMSDIYLKGWLEEIDEKL-KTDVHYRSLSGDGNFNWRMEFPFSFLTIEKKLHLSKKKLWGKCE-EVKVDAKLKIQIWENDKFSPDDFLGTRSLPLHRLPKPCSNSRWCGTKYDPGVRQNPDDDFVDLFTLHTHSIRGWWACWQHDSPSGKPK-------GKVDMSLEILTAEEAKARPVGLGRSEP 923          

Query:  658 SLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPN-IEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMI-KDETISTVFIDLHKIMNSANKE 1515
            S K + +Q+ V I+E R + G NI+PL  V  G +KQ T +K  TN+P YN+   F+F  S  EL ++++ ++  +      +R      ++G F  D  T+Y    H+F  KW +L       S ++G++KV   VL  GD+P          + N   +N+L+P  + + Q+++ ++ VY   AEDLP   + I+  +K A   + K   DPY+  SF G    TK      +P +NQ +      P     +++ + D D   K + I+T ++ L +I   +  E
Sbjct:   15 SSKPQHYQVRVKIHEGRQIPGTNIHPLVRVSVGNKKQSTSVKRSTNSPTYNQTLFFNFHASEAELFDELMTLEVFN------SRTFLSDSLLGFFESDIGTLYELPDHAFLRKWVLLTGAGVQESEDEGYLKVTAMVLGPGDEPPLSVFVAIVNNYNFFGSNLLLPAGV-RRQQAVFQLRVYF--AEDLP-QKSAILFFLKSA--EERKKSVDPYLTFSFCGKQIQTKTQHHENNPVFNQMLQLPVMLPSMCENIKLQLWDWDSFSKHDCIATAYLPLSEISGKSYGE 290          

Query:  655 LSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAI-LG-DGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSD-MIKDETISTVFIDLHKIMNSANKEEE------GFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNL--AEGVAFRGRLLIAIKTTSQPDSIKIGV-------DVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNY-LASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQ------AQLQIYLWLGLLK 2643
            LS K +DFQ+ V I E R LSG+NI+P+  V    Q + T++K+ TN PFY+E F F+F +S +EL ++II  +  +      +R +    +IG F  D    Y    H+   KW +L DP    +G KG++KV + VL  GD+   P K+ ++++ +IE N+L P  +     +    S+ VY+AED+P M++  +  IK+ + +G + K L DPY+  SFAG    T++   S  P++NQ++    +FP    RL++ + D D +  D+ I T  + +  I       E        FLP +GP +IN+YG+ R YS       D+  + NL   EGVA+RGR+L+ ++T       K+GV       D++S   +S     +R  Y LFA   EA++++   G    P+ FE+SIG  G   D    L     +  +   +++ +  Y       Y+ +P+   KPC+ + +  ED   RL   NIL ++ + L   + +VN  L +  +  +    +   ++     + K L  I +   T     LD+K Q+ +R+ +EK+ +S        S   +  A+ ++  F++ L D  ++PQ+ +PDV ++M+    R+AY RI A D+++       G+ CG V  +++K       P K   NI+      A +++ +WLGL K
Sbjct:   10 LSNKPQDFQVRVRIIEGRQLSGQNISPVARVTVANQTRQTKVKISTNKPFYDETFFFNFNMSPMELFDEIISFEVFN------SRKLRANAMIGYFKCDIGFFYEEPGHAAIRKWVLLTDPDDKMAGVKGYLKVTVMVLGPGDEA--PVKSAQDDNDDIETNLLQPSGVMLRPATF---SLKVYRAEDIPQMDSGFIEGIKRVLRVGEEQKELVDPYLLFSFAGMKARTRIHYNSDHPEFNQELNVQFKFPSMCERLKLQMFDWDRLTADDCIGTAHLPMSAISGQGEDGESWVERNISFLPMFGPCFINVYGSTREYSDLP----DEYDDLNLGNGEGVAYRGRVLVELET-------KLGVTPQSPTDDLQSHEIISVQPYLRRRKYKLFACFLEASMVSCSDG----PVEFEVSIGNYGNKLD----LSVPPSSSTTPPTNAVYDGCY-------YYFLPWGDTKPCVCVESHWEDIGFRLGTKNILTRMCERLEVNMDKVNLSLEANAQPAETATLLISLLDQLINDVRKPLPKIDN--NTPGVNDLDLKLQE-VRL-MEKLSISEEAIKLRESATDVREALGEIEGFLQRLRDLTVEPQNSMPDVIIWMLSGTKRIAYYRIPAFDVLYEPYSEACGENCGQVQNIFMK------YPGKKQQNIEDYPEVPAHVRMMIWLGLEK 650          

Query: 2710 PPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKL-----------RIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            P   I Y +   +QLR YL+  R+L+ SD  G+SDP+ +V+ G     +     T  P WD+T+I D +    + + V   PP V++E++D D    +EF+GR   +P V + G    + +L W++V RG    G+IL +F+L                    L+ +T   N + +G  +   L            +P  +RP +    +E+L WGVR +++ ++ S                V+ P I  E GG+ + S II++   +PNF+  L    + LP    + PPM+I   +   FG K +VG H +  L  +
Sbjct:  901 PRMFITYEKPHRYQLRAYLFQARDLLASDPDGVSDPYARVVFGTRSSVTETLARTLCPTWDQTLIFDEVNIYGSIEQVAENPPAVIIELYDKDPVGKDEFMGRCVVKPLVKLNGQGPPAPRLLWYDVERGDEYGGEILAAFELF-------------------LVSITKVQNASKRGNDEGTDLPFAPPMKGNLFLVPNGIRPVMQRTAIEVLCWGVRNMKKFQLAS----------------VSSPSIEFECGGHVVNSTIIKNTQKNPNFDQPLFFFDVYLPKEELYTPPMNIKVRDNRSFGRKPMVGLHALKSLQRF 1185          

Query: 4729 FEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNK-NIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCD 5685
            FEM  T P    L + + D+D +++DDLIGET +DLENR+L+ +R  CGL  TY   G  +W+DSQ P  IL   CE      P+Y  + +   ++     +    E+          P   + LH    ++    +V EH+ETR LY   +P IEQG L+MWVD+FP     P  P +ISPRKPA YELR++I  T +V L +T+  T EK  DIY+K W+   D D QKTD H+RSL G+G FNWRF+F F YL AE  +V K K + + +DE E + P  L +Q+ D+D    D  +G+L+  L++ PKPAK  + C+
Sbjct:    2 FEMNATIPIIKDLKISLMDYDLVSRDDLIGETVVDLENRFLTRYRACCGLPQTYCTSGINQWRDSQTPRQILDLFCESQGKGRPQY--LGNMKLVLDNRVYTLQEFEEGMIHHPHLGAPEQRLALH----VLNSMPVVPEHVETRSLYNSLQPNIEQGKLQMWVDIFPKHLGTPGAPFNISPRKPAEYELRVIIWNTSDVILEETS-ITGEKMSDIYVKGWLAGAD-DPQKTDVHYRSLDGEGNFNWRFIFPFMYLPAEKIMVVKKKVHFWSLDETEERVPLRLIIQIWDNDQFSPDDFLGQLELTLNRMPKPAKSARKCN 314          

Query:  646 IDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPDSIKIG-VDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYS-----------------------HLPKKEENFESQYVHSLTEPKYAYTF-DNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQK-----TNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHK-------DCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEK---LRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIE--YYVEDKINEDLDHESDHLQSLTAQ-----FDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDLDDPNLYKPEDEILVESESEDEIR 3996
            ++P S +  D+QIS+T+ EAR L G N++P+  V  G  K+ T +K  TN P+YNEYF FDF +    L ++II++  +  K+ + +     G ++G F +D  TVY    H F++KWA+L DP   T+G KG+VK D++V+  GD  K P+K ++ ++ +IE N+L+P+ +   +R      V +Y+AE LP MNT IM+N+K+A +G+ + L DPYV+V FAG  G T V   SY P WN+QI+FTE FPP   R+++ +RDSD + D  I T FIDL KI N  +K   GFLPT GP+W+N+YG+ R Y+   ++   Q  N+ + EGV+FR RLL+++      T+ P+ I    V V   + +S +  GK E + LF S  EAT++ ++IG   KP+TFE++IG  G   D  S                       +  + E   E   V   T P       D  YFH+PY  KKPC+Y+ +  +D R RL+  NI+DK+  +L E +  V  +  + +K    R ++  +E   +   + ++        A +T LD +  K     L+ M          +   T+   +K   SF++ L     +PQH +PDVF++M+ +N R+AY RI ++D+++S +  E G+ CG V   +LK      LP K       + +QA+L++YLWLG+ +  + +  GLP GF +         F S +PP  + Y  +  FQLR ++Y  R+L  +D SGLSDPF +V    H + + V  ET  P WD+ ++ D++        ++  PP +V+EI+D D+    EFIGR F +P++ +  + Y   +    L+++ +YRG   AG++L +F+L++I    K       P +E              G  D E+   L +P  +RP +  +R+E+L WG+R L+RI +                  V++PR+ IE  G  ++S +I+++  +PNF+  +    + LP N    PP++I  ++   FG   +VG H ++ L    Y   DK + +     D + +L  +      D     D V  K  D + +K  +K K G+  + + D         E+++           DWW++Y+A++  L +    KP D +L  S+ +++ R
Sbjct:  246 MEPGSGRPVDYQISITVVEARQLIGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVPPDVLFDKIIKLSVIHSKNLLRS-----GTLVGTFKMDVGTVYFQPEHQFYHKWAILSDPDDITAGCKGYVKCDIAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGI-PAERQWARFYVKIYRAEGLPKMNTTIMANVKKAFIGENRDLVDPYVQVQFAGQKGKTSVQKSSYEPIWNEQIVFTELFPPLCKRIKVQIRDSDKVNDVAIGTHFIDLRKISNDGDK---GFLPTLGPAWVNMYGSTRQYT---LMDEHQDLNEGIGEGVSFRARLLVSVAVEILDTTSPEIISSSDVQVEGVSNISESATGKMEEFFLFGSFLEATMVDRKIGD--KPITFEITIGNYGNQIDGVSKSPAAKKKKKDGENEEDENELILNSSEDEAEEEGDLVSVSTTPLMKPVITDRNYFHLPYFEKKPCVYIKSWWQDQRRRLYNSNIMDKIADKLEEGLNDVQEII-KTEKAFPERRLRGVLEELSVGCSRFVALANKDVNLAGRTKLDRERLKSCMRELDSMGQQAKQLRTQVKKNTVKDRLKLAQSFLQRLRFLADEPQHSIPDVFIWMMSNNKRIAYARIPSKDILYSTVEEETGKDCGKVKAAFLK------LPGKKSFGPAGWTVQAKLELYLWLGVNRQRKDFLSGLPNGFEEVKAVEGGPGFLS-LPPLSLVYSMKQVFQLRAHMYQARSLFAADSSGLSDPFARVFFSTHSQVTEVLSETLCPTWDQLLVFDDVELFGEASELREDPPIIVVEIYDQDTVGKAEFIGRTFAKPTIKMCDEHYGPPRFPPQLEYFQIYRGNCTAGELLAAFELLQIGQGGK----ADLPPIE--------------GSTDSERGPILPVPLGIRPVLSRYRIEVLFWGLRDLKRINLAQ----------------VDRPRVDIECAGRGVQSALIQNYKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYILVGTHAVSSLRRFIYSPPDKTSNNWASAGDVIVNLDTEPQIRKMDTVVKLDAV--KESDKEKKKKKKKKKGGLDEEEETD---------ERVL-----------DWWSKYFASIETLKEVIYVKPNDLLLKGSKIKEKSR 1339          

Query: 4225 IERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHS--VDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            ++ + +++ ELE+  ++G F+    +F+LYRGK  ++D+     DR  G FKG++C+Y +    + E+   +  +D +                         +  F S PH+  ++ +VR+YVV+  +LHPADINGKADPYI++R+G  E++D+ENYI K LNP+FG+ F++E TFP ES L V VYDWD +  DDLIGET IDLENR+ S  R TCG+ S+Y+ HGY  W+D   PT IL  LC++  I  P Y      V++  + F   + IED++G + ++ E LAL VL++WE+I P   CKLV EH+ETRPL   +KPGIEQG +EMWVDMFPS    P P +DISPRKP  YELR++I  T+ V L D ++FT EKS DI+++ W+K    D Q TD H+ SL+G+G FNWRFVF F+YL AE+ IV  K ++++  DE EYK P  L +QV D+D   +D  +G ++  L++FP+ AK  K C  D  ++       ++FK K+V+GWWP V   +       + +E+ G VE E+ LV  EEAE +P GLGR EP PLEKPNRPD S + FL P  +I+YFI
Sbjct: 1365 VDELVVFNKELES--EFGNFEDWLHTFNLYRGKAGDDDEHALDDDRIVGRFKGSLCMYKLP---LSEEITREAGYDPN-------------------------MGMFQSIPHNDPINVLVRIYVVRATDLHPADINGKADPYIVIRLGKTEVKDKENYISKQLNPVFGKSFDIEATFPMESMLTVSVYDWDLVGTDDLIGETKIDLENRFYSKFRATCGISSSYSVHGYNIWRDPMKPTQILTRLCKEGKIDGPHYGP-GGKVKVANRIFTGPTEIEDENGLKKQTEEHLALTVLNHWEEI-PRVGCKLVPEHVETRPLLNPDKPGIEQGRIEMWVDMFPSDMPAPGPALDISPRKPKRYELRVIIWNTDEVILEDDDYFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRFVFPFEYLVAEEKIVISKKESMFSWDETEYKIPPRLTLQVWDADHFSADDFLGAIELDLNRFPRGAKTAKQCSLDMIRNEHELPTISIFKQKRVKGWWPFVARDE------NDEMELTGKVEAELHLVTAEEAEKSPVGLGRNEPDPLEKPNRPDTSLMWFLGPLKSIRYFI 1918          

Query:  646 IDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKT----TSQPD-SIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENF----ESQYVHSLTE---------------PKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSF---VKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLK---KMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTS-----KMPPKIIDYME-ESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSK----LQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLE-LLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEY 3636
            ++P S +  D+Q+SVT+ EAR L G N++P+  V  G+ K+ T +K  TN P+YNEYF FDF +    + ++I+++  +  K+ + +     G ++G F +D  T+YS + H F++KWA+L DP   T+G KG+VK D++V+  GD  K P+K ++ ++ +IE+N+L+P+ +   +R      + +Y+AE LP MNT IM+N+K+A +G+ K L DPYV+V FAG  G T V    Y P WN+QI FTE FPP   R++I +RDSD + D  I T F+DL  I N  +K    FLPT GP+W+N+YG+ RT+S   ++   Q  N  L EGV+FR RLLI++      TS P+ S    V V     +S +  GK E + LF S  EAT+I ++IG   KP+ FE++I             PK E+      E++ +H+ +E               P       + YFH+PY  +KPC+Y+ +  +D + RL+  NI+D +  +L + +  VN +  + +K    R ++  +E       + L+     +  + +T LD +  KL    +E + +        +   T+   +K   +F   ++FL D   +PQH +PDVF++MI +  R+AY RI ++D+++S+I  EKG+ CG V T++L+   K  F        + +Q++++IYLWLGL +  + Y  GLP GF ++  +        PP  + YM  +  FQLRV++Y  R+L  +D +GLSDPF +V      + + V  ET  P WD+ ++ +N+        ++  PP +V+EI+D D+    +F+GR F +P V +  + Y   +    L+++ +YRG   AG++L +F+L++I P  K       P ++   +M        +G      L +P  +RP +  +R+E +L WG+R L+R+ +                  V++PR+ IE  G  ++S +I ++  +PNF+  +    + LP N    PP++I  ++   FG   +VG++ ++ L ++
Sbjct:   47 MEPSSGRPVDYQVSVTVIEARQLVGLNMDPMVCVEIGEDKKYTSMKESTNCPYYNEYFVFDFHVPPDVMFDKILKVSVIHSKNLLRS-----GTLVGTFKLDVGTIYS-QPHQFYHKWALLSDPDDITAGGKGYVKCDIAVVAKGDTIKTPHKANESDEDDIESNLLLPEGV-PAERQWARYYLKIYKAEGLPRMNTSIMANVKKAFIGENKDLVDPYVQVQFAGQKGKTSVQKSCYEPIWNEQIAFTEMFPPLCRRMKIQLRDSDKVNDVAIGTHFLDLRNISNDGDK----FLPTLGPAWVNMYGSTRTFS---LLDEYQELNDGLGEGVSFRARLLISLGVEILDTSSPEISCSTEVQVEGVPNISESATGKVEEFFLFGSFLEATMIDRKIGD--KPINFEVTIYYGNEIDGALQPKPKGEKGKGDEEETELIHNSSEEEMEDDGDLTSVATTPPMKPVITDNYFHLPYFERKPCIYIKSLWQDQKRRLYNSNIIDNIADKLEDGLNDVNEII-KTEKAYPERRLRGVLEELSQGC-QFLALANKDQNQSGRTKLDKERLKLCLSEVEAIGLQAKAMRSQVKKSTVRDKLKLSQNFLSKLRFLAD---EPQHSVPDVFIWMISNGKRIAYARIPSKDILYSSIDEEKGKDCGKVKTIFLRIPGKKGFG----PAGWTVQSKIEIYLWLGLTRQRKDYLNGLPNGFEENKLSKGPGLPSTPPISLTYMSVKQIFQLRVHMYQARSLFAADSTGLSDPFARVFFSTQSQVTEVLAETLCPTWDQLLVFENVELFGEAVELRDDPPIIVIEIYDQDTVGKADFMGRTFAKPVVKMADEHYGPPRFPPQLEYYQIYRGNCAAGEMLAAFELLQIGPNGK----ADLPPIDGPTDM-------DRG----PILPVPLGIRPVLSKYRIEQVLFWGLRDLKRVNLAQ----------------VDRPRVDIECAGKGVQSALIPNFKKNPNFSTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSNAVSSLRKF 1028          

Query: 4237 KIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDD-GYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPE--CKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVY-KNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSC--DPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKP 5913
            ++Y  ELE+  ++  F+    +F L+RGK  ++DD     +DR  G FKG++C+Y V +D   +         +S +  F                        + +   V+ +VR+YVV+  +LHPADINGKADPYI +++G  EI+D+ENYI K LNP+FG  F++E TFP +S L V +YDWD +  DDLIGET IDLENR+ S HR TCG+     NHGY  W+D   PT IL  LC+   +  P Y      V++  + F + + IED++  + K+ E LAL VL +WE+I P   CKLV EH+ETRPL   +KPGIEQG +E+WVDMFP     P P +DISPRKP  +ELR++I  T+ V L D + FT EKS DI+++ W+K    D Q TD H+ S++G+G FNWRFV+ FDYL AE+ IV  K ++++  DE EYK P  LN+QV D+D   +D  +  ++  L++FP+ AK  K C  +   +       ++FK K+++GWWP V         EE+  E+ G VE E+ L+ GEEAE +PAG GR EP PLEKP
Sbjct: 1111 EVYPKELES--EFDNFEDWLHTFYLFRGKAGDDDDQTVADEDRIVGKFKGSMCMYKVSDDAPRDMSF------DSNMGMFQN----------------------IPNNDPVNVLVRIYVVRATDLHPADINGKADPYIAIKLGKTEIKDKENYISKQLNPLFG-SFDVEATFPMDSTLTVSIYDWDLVGTDDLIGETKIDLENRFYSKHRATCGVA----NHGYNVWRDPMKPTHILAKLCKDGKLDGPHYGP-GGRVKVENRVFMAPTEIEDENLKK-KTDEHLALCVLTHWEEI-PRVGCKLVPEHVETRPLLHPDKPGIEQGRIELWVDMFPKEMTAPGPALDISPRKP-KFELRVIIWNTDEVVLEDDDIFTGEKSSDIFVR-WLKGQQEDKQDTDVHYHSITGEGNFNWRFVYPFDYLMAEEKIVISKKESMFAWDETEYKIPPRLNLQVWDADHFSADDFLA-IELDLNRFPRGAKTAKQCTIEMVTNEAEMPMVSIFKQKRIKGWWPFV------ARNEEDEFELTGKVEAELHLLTGEEAEKSPAGEGRNEPEPLEKP 1629          

Query: 4240 IYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDI-VPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +Y+ ELE   D+G F     ++ L+RGK  EE+   +  +RF G FK   C+Y + E          E+  E     F                   ++ + +     V  ++RVYVV   NLHPAD +GKADPYI++R+G  EI+DR+NYIPK LNP+FG  FEM+ TFPQES L V +YD+D +  DDLIGET IDLENR+ S HR TCGL + Y+  GY  W+DS  P+ +L  +C +N +  P++      + +  K F+  ++   +    ++S E L+L +LH W +I    CKLV EHIETR LY + +PG++QG ++MWVDMFP     P PP+DISPRKP  YELRI+I  TE+V L D+NF T ++S DIY+K                                          +V K  NI+ +D+ E K P  L +QV D + L SD  +G L+  L  FP  AK  K+C     +    + ++F+ K+ RGWWP                E+ G VE E  LV  EEAE NP G  R+EP PL KP RPD SF  F+NP+    + +
Sbjct:    1 LYNRELE--ADFGQFDDWVNTYELFRGKANEEEGSSD--ERFVGKFKARFCLYKLAE----------EEWGEGSDPGF------------------FRVSRGIPANSPVQVLIRVYVVSASNLHPADPDGKADPYIVLRLGKNEIKDRDNYIPKQLNPVFG-SFEMQATFPQESLLSVVIYDFDLVGGDDLIGETRIDLENRFYSRHRATCGLPTEYS-EGYNAWRDSLKPSELLSKMCRENGLDAPRFSP--GKISVADKVFHGKTLYMHE--QPVESYEHLSLKILHRWSEIPAVGCKLVPEHIETRVLYNKARPGMDQGQVQMWVDMFPMDLPHPGPPVDISPRKP-KYELRIIIWNTEDVILDDSNFLTGQQSSDIYVKV----------------------------------------VVVRKRDNIFSLDKTEQKLPAILILQVWDFETLSSDDFLGTLELDLHGFPPGAKTAKACKAEMLTGRTERISIFQQKRARGWWPF-----------SKSGELTGKVEAEFHLVTAEEAEKNPVGRARKEPEPLPKP-RPDTSFSWFMNPFKCFFHLV 490          

Query:  451 NVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFK----LPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILG---DGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSD-MIKDETISTVFIDLHKIMNSAN-------KEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKI--GVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIK-----SCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEK-GQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLY 2658
            ++PS N+  L  +  +I +    S+ E+  D  D E + D+  + G      S+    + +      +    L+ K +DFQI V + EAR L G NI P+ +V+   Q   T +K   N PF++E F ++  +   +L EQ I  +  +  S      +    ++GEF +D   VY   +H    KW +L DP   +SG KG++KV L V+  GD+P    +   ++  +IE+N+L+P  +  T R    +S+ V++AED+P M+   + +IK+ I G   + K L DP++E  FAG    T++I ++ +P+WNQ +    +FP    R+++ V D D +  ++ + T ++DL KI +S         + E GFLP +GP +INLYG+PR ++       D   N    EGVA+RGR+L+ + T     + K    + ++  + +S      R  Y L A    A++I QE G   +P+ FE+SIG  G            + +   + + S T+   A    NQY+++P+ + KP + + +  ED   RL   NI+      LC   R  + L +    + A     K  E +   +D+++  ++        G +  T LD++ +K   + L  +K   +V         I   + D+ ++V  L     +PQ+ +PDV ++M++   RVAY+RI A +++ S    +  G+ CG   TV+LK      + +     +  Q+++ +WLGL  D + +
Sbjct:   98 SLPSKNVPLLGENGQNIGVGFIFSACEAGGDENDGETATDLG-QSGSAGVPSSIKQSANVRQRLTRGQSRHRLATKPQDFQIRVRVVEARQLPGNNIKPVVKVHVCGQTHRTRIK-SGNNPFFDEMFFYNVHMLPSDLFEQSISFRVYNSYS------LRADSLMGEFKLDVGYVYDEPAHCVMRKWLLLNDPDDSSSGAKGYLKVSLFVIGTGDEPLVEKRDCDDDQDDIESNLLLPAGM--TLR-WATLSLKVFRAEDIPQMDDAFVQSIKE-IFGAEENKKNLVDPFLEARFAGKKLCTQIIEKNANPEWNQVLHLQVKFPSMCERVKLTVFDWDRLTGNDAVGTTYLDLAKIASSGGEIEGNPVESEVGFLPVFGPCYINLYGSPREFTGLPDPYDD--LNFGKGEGVAYRGRILVELSTKLDEKAEKTIDNIHIKRTSIISI----LRRKYCLCAVFHSASMI-QEPG---EPIQFEVSIGNYG-----------NKLDTTCKPLASTTQYSCAVFDGNQYYYLPWANTKPVVVLTSFWEDISHRLNAVNII------LCITHRLQSNLEAFKVAILAKVPDNKLAEVWLQLLDQLIEDLERFPTPELEGCSNLTSLDIQLKKRRDITLNSIKE--AVLRMRQEASEIRDTLSDIETWVDKLKQLAEEPQNSMPDVVIWMLRGEKRVAYSRIPAHEILFSTYSEQACGKNCGKTQTVFLKYP----MDKAKGLKVPVQIRVSMWLGLSADEKKF 811          

Query: 2746 FQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKST-VFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDLD--DPNLYKPEDEILV 3969
            + LRVY+Y  RNL+  D    SDP+  V    H+ K+T     T +P WD+T+I +++    +P+ +   PPDVVLE +D D    +E +GR  C P V +  +   S +L W  + +    AG++LV+ +LI  D  S    +P  P +                 + E    +P  +RP + L  +E+L WG+R ++  ++ S                V+ P +++E GG R+++ II++    PNF  N++ + + LP +  + PP+ +  I++  FG K VVG   I  L ++  +  +       S  +  + A                       P K  A    ++ P                +  +E E+ DWW+++YA+ G+ D   P L K  D + V
Sbjct: 1088 YHLRVYVYQARNLMSMDKDSFSDPYAHVSF-LHVSKTTEKLKATLNPTWDQTLIFNSVEIYGDPQKIAHRPPDVVLEFYDEDQVGKDEMLGRSICTPLVKLSPEMDQSPRLFWHPIIQKGQRAGEVLVAAELILKDK-SGDSDLPLLPPM-----------------RAENLYMVPQGIRPVVQLTAVEILAWGLRNMKPYQLAS----------------VSSPSLVVECGGQRVETAIIKNMKKSPNFPGNILFIKVLLPKDEMYTPPIVLKVIDHRPFGRKPVVGQCTIASLEDFRCDPYVIVSEGARSSKMALMMAS----------------------PHKDVAITMEESSP---------------LLEAQEKETVDWWSKFYASTGEQDKCGPYLKKGYDTLKV 1426          

Query: 4228 ERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFN----SDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIP-PPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCD----PFQHSDACAKF---NLFKNKKVRGWWPLVYNPKXXXXXXXNG--LEIGGTVEMEMDLVLGEEAESNPAGLGREEP--LPLEKPNRPDGSFLNFLNPWNTIKYF--IKYR 5985
            + +K+Y+CELE ++ + G     R+ +L++GK  ++D+   +  +F    +G+  IY           L D+    +    F E                      L +    + +VR+YVV+ I +   D NGK DPYI + +G K + DR+NY P TL+P FG  FE+  T PQ+  L + VYD+D+ ++D+ +GET IDLE+R LS  R  CGL  TY + G  +W+D   P+ IL+++ +   +PPP  ++   ++   GK ++    ++ +I    G +    E L+L VL N         LV EH+ETR L    K  + QG ++MWVD+FP    +P PP +ISPRK A Y LR++I  T +V L D +  T EK+ DIY+K                      +  +NW                         D+ EY+ P  L +Q+ D+D +  D  +  ++  L +   PAK  + C     P       +K    +LF  K VRGWWP            +NG  +   G VEM +++V  +EAE  PAG GR EP   P   P RP  SF  F N  + +K+   IK+R
Sbjct: 1307 DTLKVYNCELEKVEQFQGLTDFCRTINLHQGKTVDDDEDPSVVGQFK---QGSFKIY----------PLSDDPSVPAPPCQFKE----------------------LPESGPQECLVRIYVVRCIEVQSKDSNGKCDPYIKITLGKKTLDDRDNYKPNTLSPEFGM-FELSCTLPQDKDLKIAVYDFDKWSRDEEVGETVIDLEDRLLSYFRPCCGLPQTYCS-GVNQWRDQLKPSQILQNVAKMRGVPPPSIEEDGRSLLFSGKRYHLQDFANILIHSHLGPE---KERLSLHVLRN-------LGLVPEHVETRTLSSSYKSNLSQGRIQMWVDIFPKRLGLPGPPCEISPRK-AKYFLRVIIWNTSDVILDDAS-ITAEKTSDIYVKQ---------------------EQFWNW-------------------------DKTEYRNPPKLIVQIWDNDRISLDDYLS-VELDLLRLVPPAKTPEKCTLKMLPGMKGTVASKAKPTSLFSRKSVRGWWPCA--------NAQNGSCVLTQGKVEMTLEIVDEKEAEERPAGRGRNEPNMNPKLDPPRPATSFAWFTNVSSILKFMTRIKFR 1806          

Query:  640 KHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDG--KALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNIL----DKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLS--AIKSCRGTAKKTLLDVKYQKLIRMGLEK-MKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEK-GQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGL 2637
            K   PL+ + +DFQI V + E R L G +I P+  V    +   T ++   N PF++E F ++  +S  +L ++                                       H+   KW +L DP   T G +G++KV + ++  GD+    N+  + E  ++E+N+L+P  +     +   +S+ VY+AED+P  +   +  +KQ + G+G  K L DPY+EVSFAG    TK+I ++ +P+WNQ I                      +KD+ I T F++L +I +S    E GFLP +GP ++NLYG+PR   Y ++    +  N    EGVA+RGR+L+ + +T     ++  VD    + V      +R  Y L  S+F +  + QE G    P+ FE+++G  G           K ++     V   T P     FDN Y+++P+   KP + + +  ED   RL   NIL    D+L+  L       N L +    + A     +  E +   +D ++    + +       T+LD++ + L    +   M+M+  +  E   + +    I+D    +K L +   +PQ+ +PDV ++M +   RVAY R+ A  +++S+   +  G+ CG + T++++      + +     I A+L+  +WLGL
Sbjct:  139 KRNKPLASEAQDFQIRVRVIEGRHLPGIDIKPVVRVLFDGKTHRTNVR-GGNNPFFDEMFFYNVNMSLSDLSDE---------------------------------------HAIMRKWLLLKDPDDSTMGARGYLKVSIIIMGTGDEAPIENRLFRAEQDDLESNLLVPAGVSMRTAT---LSLKVYRAEDMP-QDDATVQTLKQFLGGEGDKKNLVDPYLEVSFAGKKVCTKIIQKNANPEWNQLISLN-------------------VKDDVIGTTFLNLSQISHSGGNVEVGFLPAFGPCFVNLYGSPR--EYGDLPDRFEELNFGNGEGVAYRGRVLVEL-STHLDKKVEKNVDDIPRDDVLVAQFQRRRRYSL-CSVFHSACMLQEPG---GPIRFEVTLGNYG----------NKLDSTCKPLVS--TTPNCFAVFDNHYYYLPWADTKPVVILTSYWEDISHRLDAINILLFTADQLESNL-------NLLKT---AISAKEPESRLTEIWLKLLDHIIEELVLPALEDRLNVTVLDLQKKNLREAAVYNIMQMACCMKEEARDIGSTVADIEDWLDRIKQLAE---EPQNSMPDVIIWMFRGEKRVAYARVPANQILYSSFSKQACGKHCGKIQTIFMQYP----MDKNKGVKIPAELRFNMWLGL 715          

Query: 2713 PKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLE-LLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSD-GVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDLDDPNLY 3945
            P +  +     + LRVY+Y GRNL   D +  S P+  V      + + V   T +PIWD+T+I ++I  + +P+ V +CPP+VVLE++D D    +E +G     P + ++ +     KLQW  + +    AG++L++ +L+          VP                      + E+   +P  ++P + L  +E +L WG+R ++  +                + PV+ P +I+E GG  +K+ II+++  +PNF  + + ++  LP    + PP+ +  I++  FG K VVG   I  L E+  +                       + NSD  +S++A               + +DA+ +V   V        R + +   E+ DWW+++Y++LG+    N Y
Sbjct:  969 PTVSCHFSSYIYHLRVYIYQGRNLCPMDHNSFS-PYAHVSFLHMSKTTHVIQNTLNPIWDQTLIFEDIEIHGDPQTVASCPPEVVLELYDSDQVGKDEPMGHCKYPPLINLQPNIGCRPKLQWLPITKKGHNAGELLLAAELLLKLDDDDLPIVP--------------------PRRSEKLYMVPQGIKPVVQLTAIEQVLTWGLRNMEAFQ----------------LSPVSSPSLIVECGGETVKTAIIKNFKKNPNFPGS-VLLLKLLPKEEMYAPPIVLKVIDHKPFGWKPVVGQCTIRSLGEFRCD---------------------PYRTNSDICMSSRA---------------MMADAQENVVIDVES------RAISETRDEAVDWWSKFYSSLGEQQKCNPY 1301          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDLDDPNLYKPEDEILVESESEDEIRRDIFLGYRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLFQHKSTKELFLKEVQEHLILEDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIVDKITGG 6105
            MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDLDDPNLYKPEDEILVESESEDEIRRDIFLGYRVETHSEDEEDEVVEIPEDIPKKKKKKKKKKKKKKKKRLFQHKSTKELFLKEVQEHLILEDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDENKTEEELLNEKSNLKLYKFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKDEDEEEENGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRLKWILIKILIVLIFVLIIVLFIYNFPGNFSRVIVDKITGG
Sbjct:    1 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPKEEMESADWWTRYYATLGDLDDPNLYKPEDEILVESESEDEIRRDIFLGYRVETHSEDEEDEVVEIPEDIPKKKKKKKKKKKKKKKKRLFQHKSTKELFLKEVQEHLILEDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDENKTEEELLNEKSNLKLYKFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKDEDEEEENGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRLKWILIKILIVLIFVLIIVLFIYNFPGNFSRVIVDKITGG 2017          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLTKLERHEGHIRLPSDTSSVES----DSDNGDNEPSDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGDKPKRPNKTDKEEDPNIEANILIPQILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTTSQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSHLPKKEENFESQYVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKKMNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVNDNSKGEKDEEKLRIPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKIN--EDLDHESDHLQSLTA--QFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTNPVPGEPEKLIRFVPK-EEMESADWWTRYYATLGDLDDPNLYKPEDEILVESESEDEIRRDIFLGYRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRL--FQHKSTKELFLKEVQEHLILEDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNV 4404
            MSL V L+ L G  QG + +IK++FRD + ++   KT  +   G RF WPIARK+DK D L++K    NR G DKL GV+ I    L+ +  +N+ E  VDE+M+ITDI + FEIEY SP +G++N G   FN P YNL  L+R    + LPS+ SS E     DSD+GD     D +++D  + S++SLLP+RDFKLPKHIDP SLKI+DFQISVTI EARGL G NINP+FEVYCGKQKQ TE+KMQTN+PFYNE+F+FD  +SRLE+ME II+I+ LSK +++V + IF GKV+GEFSIDAK+VY+NE HSFF KWA LIDPK+PTSGEKG+VKVD+SVLCAGDKPKRP+  D EE+PNIEAN+LIP  +  T R +CEM+V +YQAEDLPCMNT I+SNIK AI G+GKAL D YVEVSFAGYTG TKV++R+YSPDWNQQIIFTERFPP+V+RLRIAVRD+DM+KDETIST+FIDL KIM + +KEEEGFLPTYGPSWINLYGTPRT++Y ++IKGDQGQNQNLAEGVA+RGRL+IAIKT+ QPDS KIGVDVR CNPVSN VAGKRE+YLLF  I+E TLI +++GK  KPLTFE+SIG TG   D+Y+     +   E+QYVHS+T+ ++AYT+DN+YFHIPY++KKPCL+MI  SEDHRPR+FIPNI++KLK+EL E +RQ ++L    K +QA RY+K S+     SI+KV+S +KSCRGTAKKT+LDVKYQ+LIR+ LEKMK+        L    +   +++ N+ VK L+DKM DPQ+GLPD+F+YMIQ+NIRVAY RI AR++IHS++ PEKG MCGM+NTVYLK+++ S+L   T+YNIQAQLQIYLWLGLL+DMR YKMGLPEG++++CF+ KMPPK IDY++ES FQLRVYL+M RN+IGSDDSGLSDPF ++IIGEH+ KST+F +TRSPIWDET+IIDNI+FNY P ++K+ PP+VV+EIFDWDSDTDEEF+GRVFC+P V+I+GD+YT++KLQWW++YRGT+ AG+IL +FDL+E+D  +K+I V G P+++++ +MT+++NDN  GE DE KLRIP  +RP +  FR E+L+WGVRQLQRIE++  K++  +  KR GIFPVNQP+I I+I GYRI+SD I DW   PNF DNL+ + LRLP +++FWPP+SINC N T+FGLKQ+VGN  IT+L++YY  D+++   ++D  +   +S+ +   F+   +++G+ N+ F+N+D     +     +    PDVT PVPG  EK+   +P+ EEMESADWWTRYYAT+GDL D  + K   E L ESES++E+   +     +  +S+++E++VV+IP+D PKKKKKKKKK+KKKK+K    FQ  STKELFLKE  ++L +E E ++DNSWIERI +Y CELEN+KD+GGF  PF+SFSLYRGKQEE+DD +E  DRF GVFKGNICIYN+
Sbjct:    1 MSLSVNLKYLDGAAQGGDKYIKLMFRDVEKKSNRLKTSANIYFGQRFNWPIARKMDKNDILILKCYNANRVGGDKLLGVLQIATGNLINEPSMNVRENLVDERMKITDIIVAFEIEYFSPSTGSDNFGSDAFNFPVYNLKTLKRTSKKVTLPSENSSDEDEEYYDSDDGDGR---DNNIRD--DISDISLLPDRDFKLPKHIDPQSLKIEDFQISVTIVEARGLCGNNINPMFEVYCGKQKQNTEIKMQTNSPFYNEFFTFDLTMSRLEMMELIIKIRGLSKSNNVVAQRIFTGKVLGEFSIDAKSVYTNEGHSFFRKWAPLIDPKSPTSGEKGYVKVDISVLCAGDKPKRPDADDNEENPNIEANLLIPLCVSNTPRKMCEMAVLIYQAEDLPCMNTNIISNIKHAIYGEGKALTDAYVEVSFAGYTGRTKVVNRNYSPDWNQQIIFTERFPPFVTRLRIAVRDNDMVKDETISTIFIDLQKIMYTGSKEEEGFLPTYGPSWINLYGTPRTFTYTQLIKGDQGQNQNLAEGVAYRGRLMIAIKTSYQPDSSKIGVDVRPCNPVSNTVAGKREMYLLFGGIYETTLINEDLGKNGKPLTFEMSIGITGNLLDDYA-----KPTPENQYVHSMTQSRFAYTYDNKYFHIPYKNKKPCLFMITQSEDHRPRMFIPNIIEKLKRELSEIIRQTSHLRLE-KNIQARRYLKTSIINLIPSIEKVVSGVKSCRGTAKKTMLDVKYQRLIRLDLEKMKVKLQNLALELKRSNVYEKMRECNTLVKLLEDKMADPQYGLPDIFIYMIQENIRVAYARIKAREIIHSSMAPEKGIMCGMMNTVYLKRLDNSLLKLNTSYNIQAQLQIYLWLGLLRDMRGYKMGLPEGYNRECFSGKMPPKYIDYLDESMFQLRVYLFMARNVIGSDDSGLSDPFARIIIGEHVAKSTIFTQTRSPIWDETLIIDNIIFNYAPDVLKSSPPNVVVEIFDWDSDTDEEFLGRVFCQPKVYIKGDQYTTAKLQWWSIYRGTLAAGEILAAFDLVEMDMKTKKITVKGLPTVKDIKKMTSEINDNRFGEMDENKLRIPEFIRPHLSTFRFEILMWGVRQLQRIEVVHLKKNPFVASKRFGIFPVNQPKITIDIAGYRIESDKITDWTIQPNFEDNLVFLDLRLPTSTQFWPPISINCTNSTVFGLKQIVGNCAITNLVDYYQCDQVDNFREIDKTTIDERSVKSLNLFNAGNDTEGILNEGFENEDGSAINELTDMKEEKPNPDVTAPVPGTVEKVKPVLPQTEEMESADWWTRYYATIGDLGDSTIVKEVIEKLSESESDEEVTGFVLNDIEINVNSDEDEEDVVDIPDDEPKKKKKKKKKRKKKKRKFKNPFQ-PSTKELFLKEEPDNLRMESEYVTDNSWIERITMYPCELENVKDFGGFHDPFKSFSLYRGKQEEDDDNFENPDRFGGVFKGNICIYNI 1449          

Query: 4546 LSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPPPIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNIYEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQHSDACAKFNLFKNKKVRGWWPLVYNPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFIKYRXXXXXXXXXXXXXXXXXXXXXXYNFPGNFSRVIVDKITG 6102
            L D + VDF+VRVY++K INLHP+D+NGK+DPYILV++G+KE+RDRENYIPKTLNP+FG+C E+EVTFPQESFLLVQ+YDWDRLTKDDLIGETTIDLENRWLSPH+G+CG+M +Y+NHGY+KWKD +LPT ILKSLCE++N+P P YDK+ D V+I  ++F +++MIEDDDGSQIKSLEPLAL VLH+W +IVP  KLV E+IETRPLY+ EKPGI+QGLLEMWVDM+P+GTAIP PIDI+PRK   YELR  ++QTE VRL + NFFT EK+VDI++K+WMKSTDIDLQKTD H++SLSGQGLFNWRFV+ FDYLKAED IVY  K++YEIDE EYKTPCFLNMQVLDS ++MSDTIIG+ K RLSKFP+PAK+Y+SCDPFQ S+ACAKFNLF+NKKVRGWWPL+YNPKDED +EE+G EIGG VE+EM+LV  EEAESNP GLGR EP+PLE P RPDGSFL+FLNPWNTIKYFIKYRLKWILIKI ++ + +LII LFIYNFPG+ S  IV K+ G
Sbjct: 1506 LRDINPVDFVVRVYIIKAINLHPSDLNGKSDPYILVKLGDKEVRDRENYIPKTLNPVFGKCIELEVTFPQESFLLVQIYDWDRLTKDDLIGETTIDLENRWLSPHQGSCGIMPSYHNHGYLKWKDYRLPTVILKSLCEEHNVPLPIYDKLTDRVDIDDRSFFAETMIEDDDGSQIKSLEPLALEVLHHWHEIVPGKKLVPEYIETRPLYMPEKPGIQQGLLEMWVDMYPAGTAIPAPIDITPRKAIGYELRCTVIQTEKVRLINVNFFTNEKTVDIFVKSWMKSTDIDLQKTDVHYKSLSGQGLFNWRFVYNFDYLKAEDCIVYTQKSVYEIDECEYKTPCFLNMQVLDSGIIMSDTIIGKFKCRLSKFPQPAKFYRSCDPFQLSEACAKFNLFRNKKVRGWWPLIYNPKDEDSDEEDGEEIGGCVELEMELVTAEEAESNPVGLGRAEPMPLEAPMRPDGSFLSFLNPWNTIKYFIKYRLKWILIKIFVIFMALLIIALFIYNFPGSISNAIVTKMFG 2024          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEP------------------SDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGD----KPKRPNKTDKE-EDPNIEANILIPQ-ILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTT--SQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH------LPKKEENFESQ---YVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKK-MNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTDEEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVN---DNSKGEKDEEKLR---------------------------IPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKI-----------NEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTN 3825
            M+L++ L+ +  +    +  +K+ FRD +  T   + K S   G +F WP+ RKLD +D+L ++    +++  +KL G + I L  L+    I+  E  +D    I  I ++FE+ Y SP S   N  + +F  P  +           R  SD   +  DS    ++                   +D+  V+ G++    +    R   +P  + P   K +D+QIS+T+ EAR L+G NINPL EV  G++ + TE++M TN+P+YN+Y  F+F +S+ EL +Q+IR++ L+  +  ++R + PG +IGEF +D +TVY+   H F +KWA+L+DPK   SG KG+VKVDL+++  G+    KPK   K  K+ +D +IEAN+L+PQ I   T+R + E+ V +Y+AEDLP MNT IM+ IK AI GD K L DP+V+VSFAG+TG TKV   +Y+P+WN++I+FTE FP   +R+R++V D D + +E I+T +IDL +IMN  +    GFLPT+GPSW+NLYGTPR Y+Y +M++  +  N+ L EGVA+RGRLLIAIKT   S+   +  G  V S  P+S+   GK+E +LL  + +EA++I  EIGKK++P+ FELS+GTTG   D  ++      +P   +    +   + HS TEP    T D +YFH+ +  KKPCLYMI+  EDH+ R FIPNIL+KLK E    V  ++ L    ++   +R +K +++TF  +I+  L++IK  R  + KTLLD +  KL ++ LEKM++      +  +   + + +K+  + +K L++ + +PQ+GLPD+F+++IQD  R+A+ RI AR++++SAIP EKG     V TV+L+K   F + P  + + +Q QL++YLWLGLL+DM+ ++ GLP G+  DCF  + PP  I Y E+S FQLR +++M RNLIGSD+SGLSD F ++++ +H+  + V +ET SP WD+T+IID+++F Y+  ++ + PP +V+E+FD D     EF+GR FC+P+V +  +EY S +L WW +YRG M AG++L +F+LI++ P        G P +E ++  ++ +     NS   + E  L                            +P ++RP +  +R+E L WGVR++QR++++S                V++PRI IE G   + SD+I      PNF++ L  + + LP N  +WPP+ I C +   FG   ++GNHVI+++ +Y ++ KI           N    ++ ++L++   +  + A  +GV N A+ +      E T AG  S A+   TN
Sbjct:    1 MALVLNLKYVDNLDNRCDRIVKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIANWRQDEFENPITD-----------RKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESVESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISR-LLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVKHKPKSATKKPKDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEGDT---GFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLR-MKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGP--SGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIPRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDITPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMS----------------VDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDD-----ETTAAGNLSSARKSSTN 1295          

Query: 3862 VPKEEMESADWWTRYYATLGDLDDPNLYKPEDEIL-VESESEDEIRRDIFLGYRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLFQH-------KSTKELFLKEVQEHLILEDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPP-PIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNI-YEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQ--HSDACAKFNLFKNKKVRGWWPLVY----NPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +PK+E++  DWW+RYY ++ DLDD       D  L V  + E +++ D   G   E   ++E+    +  +   KKKKK KK KKK   K +F          + K L  K+  +    ++ K   ++ IER K+Y C LE +K++ GF    ++F L +G+Q+++++  +  +R  G FKGN+ IY V ++       F  + D  KL  +                        L +   V  +VR+YV++  +LHPAD NGK+DPY+L+R+GNK I ++ENYIPK LNPIFG+CFE++V FPQES LL+QV DWD ++ DD+IGET IDLENR+ S H+  CGL   + NHGY KW+D QLPT +L  LC++    PPKY+ + + V +    F +D+ IE+D+G + +S EPLAL V+ NW  +   C LV EH+ETRPL+  EKPGI+QG LEMW+DMFP     PP PIDI+PR+P SYELR++I  TE+V L+D    T EKS DI++K WMK   ID Q TD H+RSLSG+G FNWRF+F FDY+KAED IVYK K+  + IDE E K+PC L +QV D+DL+ +D  +G L+  LSK P+ AK  ++C   Q     + +  ++FKNK+ RGWWP       +PK+        L++ G ++ E  L+  EE E+ P GLGR EP  L  PNRPD SFLNF+NP  ++KY I
Sbjct: 1433 IPKDELQDIDWWSRYYVSIEDLDDDGQEDSSDSNLDVLKDIEVDVKSDDDQGGLAEIPEDEEDSSKTKKKKKKRKKKKKSKKDKKKDGDKGIFAKLPFGRVDAAKKYLEEKDDDDFEDEDNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSD--NRIVGNFKGNLNIYKVDDEE------FGVEVDVHKLMLYKS----------------------LPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKE--------LDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLI 2115          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEP------------------SDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGD----KPKRPNKTDKE-EDPNIEANILIPQ-ILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTT--SQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH------LPKKEENFESQ---YVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKK-MNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTD--------EEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVN---DNSKGEKDEEKLR---------------------------IPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKI-----------NEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDNKDEKGPEKTKAGVKSDAKPDVTN 3825
            M+L++ L+ +  +    +  +K+ FRD +  T   + K S   G +F WP+ RKLD +D+L ++    +++  +KL G + I L  L+    I+  E  +D    I  I ++FE+ Y SP S   N  + +F  P  +           R  SD   +  DS    ++                   +D+  V+ G++    +    R   +P  + P   K +D+QIS+T+ EAR L+G NINPL EV  G++ + TE++M TN+P+YN+Y  F+F +S+ EL +Q+IR++ L+  +  ++R + PG +IGEF +D +TVY+   H F +KWA+L+DPK   SG KG+VKVDL+++  G+    KPK   K  K+ +D +IEAN+L+PQ I   T+R + E+ V +Y+AEDLP MNT IM+ IK AI GD K L DP+V+VSFAG+TG TKV   +Y+P+WN++I+FTE FP   +R+R++V D D + +E I+T +IDL +IMN     + GFLPT+GPSW+NLYGTPR Y+Y +M++  +  N+ L EGVA+RGRLLIAIKT   S+   +  G  V S  P+S+   GK+E +LL  + +EA++I  EIGKK++P+ FELS+GTTG   D  ++      +P   +    +   + HS TEP    T D +YFH+ +  KKPCLYMI+  EDH+ R FIPNIL+KLK E    V  ++ L    ++   +R +K +++TF  +I+  L++IK  R  + KTLLD +  KL ++ LEKM++      +  +   + + +K+  + +K L++ + +PQ+GLPD+F+++IQD  R+A+ RI AR++++SAIP EKG     V TV+L+K   F + P  + + +Q QL++YLWLGLL+DM+ ++ GLP G+  DCF  + PP  I Y E+S FQLR +++M RNLIGSD+SGLSD F ++++ +H+  + V +ET SP WD+T+IID+++F Y+  ++ + PP +V+E+FD D  T          EF+GR FC+P+V +  +EY S +L WW +YRG M AG++L +F+LI++ P        G P +E ++  ++ +     NS   + E  L                            +P ++RP +  +R+E L WGVR++QR++++S                V++PRI IE G   + SD+I      PNF++ L  + + LP N  +WPP+ I C +   FG   ++GNHVI+++ +Y ++ KI           N    ++ ++L++   +  + A  +GV N A+ +      E T AG  S A+   TN
Sbjct:    1 MALVLNLKYVDNLDNRCDRIVKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIANWRQDEFENPITD-----------RKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESVESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISR-LLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVKHKPKSATKKPKDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEG---DTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLR-MKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGP--SGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIPRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDITPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMS----------------VDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTEEPAKKVITNTSSPNQQNNLETPEDKIAIPAIIEGVDNPAYIDD-----ETTAAGNLSSARKSSTN 1303          

Query: 3862 VPKEEMESADWWTRYYATLGDLDDPNLYKPEDEIL-VESESEDEIRRDIFLGYRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLFQH-------KSTKELFLKEVQEHLILEDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPP-PIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNI-YEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQ--HSDACAKFNLFKNKKVRGWWPLVY----NPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +PK+E++  DWW+RYY ++ DLDD       D  L V  + E +++ D   G   E   ++E+    +  +   KKKKK KK KKK   K +F          + K L  K+  +    ++ K   ++ IER K+Y C LE +K++ GF    ++F L +G+Q+++++  +  +R  G FKGN+ IY V ++       F  + D  KL  +                        L +   V  +VR+YV++  +LHPAD NGK+DPY+L+R+GNK I ++ENYIPK LNPIFG+CFE++V FPQES LL+QV DWD ++ DD+IGET IDLENR+ S H+  CGL   + NHGY KW+D QLPT +L  LC++    PPKY+ + + V +    F +D+ IE+D+G + +S EPLAL V+ NW  +   C LV EH+ETRPL+  EKPGI+QG LEMW+DMFP     PP PIDI+PR+P SYELR++I  TE+V L+D    T EKS DI++K WMK   ID Q TD H+RSLSG+G FNWRF+F FDY+KAED IVYK K+  + IDE E K+PC L +QV D+DL+ +D  +G L+  LSK P+ AK  ++C   Q     + +  ++FKNK+ RGWWP       +PK+        L++ G ++ E  L+  EE E+ P GLGR EP  L  PNRPD SFLNF+NP  ++KY I
Sbjct: 1441 IPKDELQDIDWWSRYYVSIEDLDDDGQEDSSDSNLDVLKDIEVDVKSDDDQGGLAEIPEDEEDSSKTKKKKKKRKKKKKSKKDKKKDGDKGIFAKLPFGRVDAAKKYLEEKDDDDFEDEDNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSD--NRIVGNFKGNLNIYKVDDEE------FGVEVDVHKLMLYKS----------------------LPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKE--------LDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLI 2123          

Query:   55 MSLIVTLQSLTGVKQGQEGFIKVIFRDHQFRTPNFKTKPSTNLGSRFVWPIARKLDKVDSLVIKFILLNRFGPDKLTGVINIVLSTLMVQQCINLDETFVDEQMRITDIALNFEIEYNSPVSGNENLGKSDFNVPSYNLTKLERHEGHIRLPSDTSSVESDSDNGDNEP------------------SDDIDVKDGDNYSELSLLPERDFKLPKHIDPLSLKIKDFQISVTIYEARGLSGKNINPLFEVYCGKQKQCTELKMQTNTPFYNEYFSFDFRISRLELMEQIIRIKALSKKSHIVTRHIFPGKVIGEFSIDAKTVYSNESHSFFYKWAVLIDPKAPTSGEKGWVKVDLSVLCAGD----KPKRPNKTDKE-EDPNIEANILIPQ-ILCQTQRSICEMSVYVYQAEDLPCMNTKIMSNIKQAILGDGKALADPYVEVSFAGYTGSTKVISRSYSPDWNQQIIFTERFPPYVSRLRIAVRDSDMIKDETISTVFIDLHKIMNSANKEEEGFLPTYGPSWINLYGTPRTYSYAEMIKGDQGQNQNLAEGVAFRGRLLIAIKTT--SQPDSIKIGVDVRSCNPVSNNVAGKRELYLLFASIFEATLITQEIGKKRKPLTFELSIGTTGICPDEYSH------LPKKEENFESQ---YVHSLTEPKYAYTFDNQYFHIPYRSKKPCLYMIAPSEDHRPRLFIPNILDKLKQELCEYVRQVNYLASRGKKVQAMRYIKKSMETFFISIDKVLSAIKSCRGTAKKTLLDVKYQKLIRMGLEKMKMSWSVTIECLSVCTIDMAIKDLNSFVKFLDDKMLDPQHGLPDVFLYMIQDNIRVAYTRILARDLIHSAIPPEKGQMCGMVNTVYLKK-MNFSILPQKTNYNIQAQLQIYLWLGLLKDMRLYKMGLPEGFHKDCFTSKMPPKIIDYMEESDFQLRVYLYMGRNLIGSDDSGLSDPFVKVIIGEHIRKSTVFHETRSPIWDETIIIDNIVFNYNPKIVKTCPPDVVLEIFDWDSDTD--------EEFIGRVFCRPSVFIRGDEYTSSKLQWWNVYRGTMPAGDILVSFDLIEIDPFSKRIYVPGFPSLENLMEMTAQVN---DNSKGEKDEEKLR---------------------------IPFDVRPPIGLFRLELLIWGVRQLQRIEIISPKRHAVIPIKRMGIFPVNQPRIIIEIGGYRIKSDIIEDWWTHPNFNDNLISVILRLPVNSKFWPPMSINCINYTMFGLKQVVGNHVITDLIEYYVEDKINEDLDHESDHLQSLTAQFDMKANSDGVSNKAFDN 3756
            M+L++ L+ +  +    +  +K+ FRD +  T   + K S   G +F WP+ RKLD +D+L ++    +++  +KL G + I L  L+    I+  E  +D    I  I ++FE+ Y SP S   N  + +F  P  +           R  SD   +  DS    ++                   +D+  V+ G++    +    R   +P  + P   K +D+QIS+T+ EAR L+G NINPL EV  G++ + TE++M TN+P+YN+Y  F+F +S+ EL +Q+IR++ L+  +  ++R + PG +IGEF +D +TVY+   H F +KWA+L+DPK   SG KG+VKVDL+++  G+    KPK   K  K+ +D +IEAN+L+PQ I   T+R + E+ V +Y+AEDLP MNT IM+ IK AI GD K L DP+V+VSFAG+TG TKV   +Y+P+WN++I+FTE FP   +R+R++V D D + +E I+T +IDL +IMN     + GFLPT+GPSW+NLYGTPR Y+Y +M++  +  N+ L EGVA+RGRLLIAIKT   S+   +  G  V S  P+S+   GK+E +LL  + +EA++I  EIGKK++P+ FELS+GTTG   D  ++      +P   +    +   + HS TEP    T D +YFH+ +  KKPCLYMI+  EDH+ R FIPNIL+KLK E    V  ++ L    ++   +R +K +++TF  +I+  L++IK  R  + KTLLD +  KL ++ LEKM++      +  +   + + +K+  + +K L++ + +PQ+GLPD+F+++IQD  R+A+ RI AR++++SAIP EKG     V TV+L+K   F + P  + + +Q QL++YLWLGLL+DM+ ++ GLP G+  DCF  + PP  I Y E+S FQLR +++M RNLIGSD+SGLSD F ++++ +H+  + V +ET SP WD+T+IID+++F Y+  ++ + PP +V+E+FD D  T          EF+GR FC+P+V +  +EY S +L WW +YRG M AG++L +F+LI++ P        G P +E ++  ++ +     NS   + E  L                            +P ++RP +  +R+E L WGVR++QR++++S                V++PRI IE G   + SD+I      PNF++ L  + + LP N  +WPP+ I C +   FG   ++GNHVI+++ +Y ++ KI  + D E+    +L++      N +       DN
Sbjct:    1 MALVLNLKYVDNLDNRCDRIVKINFRDFEKTTKVVRGKDSIYFGEQFQWPMGRKLDPIDTLELRLYQYSKYLNNKLIGSMTISLQKLLEDYKISYKENLIDSNHSIIRITVSFELTYYSPDSQIANWRQDEFENPITD-----------RKLSDADDISIDSHGMGSDKRTLIDPQTGEIGEFNYGQTDNESVESGEDDESFAATNARTLGVPLALHPTLHKTEDWQISITVIEARQLAGANINPLIEVRIGEKTKTTEVQMSTNSPYYNQYLCFEFHMSKAELFDQVIRLRCLAMGNMAISR-LLPGDLIGEFRMDVRTVYNAPDHMFLHKWAMLVDPKDILSGAKGYVKVDLTIMGKGEQVKHKPKSATKKPKDNDDEDIEANLLLPQTIKTGTKRQMAEICVKIYKAEDLPRMNTDIMATIKMAITGDSKPLVDPFVQVSFAGHTGRTKVKKNTYTPEWNEEIVFTEMFPTLCNRIRVSVYDWDTVFNECIATHYIDLSQIMNEG---DTGFLPTFGPSWVNLYGTPRNYTYDQMMRPKEELNRGLGEGVAYRGRLLIAIKTVLRSESGGLPAGAKVYSVPPISDGTCGKKEPFLLIGAFYEASVIDSEIGKKKQPIYFELSVGTTGNRLDSEANEEEEKEVPSVNQGNRPKIPKWCHSTTEPMLPDTNDQEYFHLSFNEKKPCLYMISYHEDHKSRDFIPNILEKLKNEFSNAVEILHELHMNERRGTHLR-MKNALDTFIENIESSLNSIKCVRHVSPKTLLDKERIKLTKVCLEKMRVKAKTMYQDCTKANLAIRLKECRAIIKKLNELIPNPQNGLPDIFIWLIQDTKRMAFARIPAREILYSAIPEEKGVKNSEVVTVFLQKPGRFGMGP--SGWTLQGQLKMYLWLGLLRDMKTFQQGLPLGYSNDCFKFRRPPMEIIYTEKSYFQLRAHMFMARNLIGSDESGLSDAFARILVNDHVVTTKVVYETLSPKWDQTLIIDHMIFYYSKDLIMSNPPVLVVEMFDEDQMTGLRSNQKGKSEFLGRCFCKPTVALEEEEYKSPRLTWWEIYRGQMNAGELLAAFELIQVFPDEGYRLANGIPRIEQMIRSSSPIGSLRSNSVFSQKELLLANMEGDINGDITPNEGVTVTAEGHFVVPVPKEIRPSLVPYRVEFLFWGVREMQRVQLMS----------------VDKPRITIEFGSSHLISDVIPSCKVKPNFSNPLKYMDIMLPENLLYWPPLMIQCEDLRQFGRTILIGNHVISNVTKYVIKGKIPTE-DDETTAAGNLSSARKSSTNFNSNVQALLDN 1273          

Query: 3862 VPKEEMESADWWTRYYATLGDL-DDPNLYKPEDEILVESESEDEIRRDIFLGYRVETHSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLFQH-------KSTKELFLKEVQEHLILEDEKLSDNSWIERIKIYSCELENIKDYGGFKQPFRSFSLYRGKQEEEDDGYEIQDRFAGVFKGNICIYNVQEDNIHEKDLFDEDHDESKLASFGEQDXXXXXXXXXXXXXXXXXXXFLSDPHSVDFIVRVYVVKGINLHPADINGKADPYILVRIGNKEIRDRENYIPKTLNPIFGRCFEMEVTFPQESFLLVQVYDWDRLTKDDLIGETTIDLENRWLSPHRGTCGLMSTYNNHGYMKWKDSQLPTAILKSLCEKNNIPPPKYDKMNDTVEIMGKTFNSDSMIEDDDGSQIKSLEPLALVVLHNWEDIVPECKLVKEHIETRPLYLQEKPGIEQGLLEMWVDMFPSGTAIPP-PIDISPRKPASYELRIVILQTENVRLTDTNFFTKEKSVDIYLKAWMKSTDIDLQKTDTHFRSLSGQGLFNWRFVFQFDYLKAEDSIVYKNKNI-YEIDENEYKTPCFLNMQVLDSDLLMSDTIIGRLKFRLSKFPKPAKYYKSCDPFQ--HSDACAKFNLFKNKKVRGWWPLVY----NPKXXXXXXXNGLEIGGTVEMEMDLVLGEEAESNPAGLGREEPLPLEKPNRPDGSFLNFLNPWNTIKYFI 5976
            +PK+E++  DWW+RYY ++ DL DD      +  + V  + E +++ D   G   E   ++E+    +  +   KKKKK KK KKK   K +F          + K L  K+  +    ++ K   ++ IER K+Y C LE +K++ GF    ++F L +G+Q+++++  +  +R  G FKGN+ IY V ++       F  + D  KL  +                        L +   V  +VR+YV++  +LHPAD NGK+DPY+L+R+GNK I ++ENYIPK LNPIFG+CFE++V FPQES LL+QV DWD ++ DD+IGET IDLENR+ S H+  CGL   + NHGY KW+D QLPT +L  LC++    PPKY+ + + V +    F +D+ IE+D+G + +S EPLAL V+ NW  +   C LV EH+ETRPL+  EKPGI+QG LEMW+DMFP     PP PIDI+PR+P SYELR++I  TE+V L+D    T EKS DI++K WMK   ID Q TD H+RSLSG+G FNWRF+F FDY+KAED IVYK K+  + IDE E K+PC L +QV D+DL+ +D  +G L+  LSK P+ AK  ++C   Q     + +  ++FKNK+ RGWWP       +PK+        L++ G ++ E  L+  EE E+ P GLGR EP  L  PNRPD SFLNF+NP  ++KY I
Sbjct: 1400 IPKDELQDIDWWSRYYVSIEDLDDDGQEDSSDSNLDVLKDIEVDVKSDDDQGGLAEIPEDEEDSSKTKKKKKKRKKKKKSKKDKKKDGDKGIFAKLPFGRVDAAKKYLEEKDDDDFEDEDNVKPDYHNLIERFKVYPCPLEEVKEFEGFAAFIQTFPLQKGRQDDDEESSD--NRIVGNFKGNLNIYKVDDEE------FGVEVDVHKLMLYKS----------------------LPNNDPVQILVRIYVIRANDLHPADPNGKSDPYLLLRLGNKVINEKENYIPKQLNPIFGKCFELDVKFPQESNLLIQVMDWDLVSGDDIIGETKIDLENRYYSKHKALCGLGQIFENHGYNKWRDIQLPTMMLAKLCKEYGFDPPKYEALVNKVTVAEVAFYADAEIEEDNGEKKQSNEPLALEVMKNWSKVPNGCLLVPEHMETRPLFNSEKPGIQQGSLEMWIDMFPKELGAPPLPIDIAPRQPISYELRVIIWNTEDVILSDGGVLTGEKSSDIFVKGWMKGLGIDDQVTDVHYRSLSGEGNFNWRFIFNFDYIKAEDKIVYKIKDSPFAIDETEIKSPCKLYLQVWDADLVTADDFLGGLELILSKIPRGAKSPQTCGLHQLNKDGSVSTISIFKNKRYRGWWPFTGENEDDPKE--------LDVNGKLDAEFQLLSKEEGEACPVGLGRNEPNALPSPNRPDSSFLNFMNPLKSLKYLI 2082