Family with sequence similarity 49 member A

Overview


Name	Family with sequence similarity 49 member A
Smed ID	SMED30007853
Length (bp)	1436

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Family with sequence similarity 49 member A (SMED30007853) t-SNE clustered cells

Violin plots show distribution of expression levels for Family with sequence similarity 49 member A (SMED30007853) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Family with sequence similarity 49 member A (SMED30007853) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30007853

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30007853	h1SMcG0003784	Contig2300	GPL15192	PMID:23079596 Forsthoefel et al., 2012
pharynx	SMED30007853	h1SMcG0003784	dd_Smed_v4_1856_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30007853	h1SMcG0003784	dd_Smed_v4_1856_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30007853	h1SMcG0003784	dd_Smed_v4_1856_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30007853	h1SMcG0003784	dd_Smed_v4_1856_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30007853	h1SMcG0003784	dd_Smed_v4_1856_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30007853	h1SMcG0003784	dd_Smed_v4_1856_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30007853	h1SMcG0003784	dd_Smed_v6_1856_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018

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Homology

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Human
Match: FAM49B (family with sequence similarity 49 member B [Source:HGNC Symbol;Acc:HGNC:25216])

HSP 1 Score: 276.174 bits (705), Expect = 6.213e-89
Identity = 152/328 (46.34%), Postives = 215/328 (65.55%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K IK+++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSML 323

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Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K IK+++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSML 323

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Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K IK+++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSML 323

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Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K IK+++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSML 323

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Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K IK+++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSML 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Celegans
Match: R07G3.8 (pep chromosome:WBcel235:II:7618238:7620513:-1 gene:WBGene00019944.1 transcript:R07G3.8.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R07G3.8)

HSP 1 Score: 160.229 bits (404), Expect = 9.085e-45
Identity = 103/332 (31.02%), Postives = 171/332 (51.51%), Query Frame = 1

Query:   76 GNILKLLSRNIEETKDDSN----VFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLP-QTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
             + L+++   I  T DD++    +F+DFEN QPT+ E+ IY+     L     +L  + +Y       +  + N ++    K    ++ P +      YE   ++ + VP ++  L S    + E L +KQ+  KQFA ++ F+L+FD +KM +  I ND SYYRR         +D  V +   V         +F  E  PMLK +   +  +     S+PI  TT+   T+  +CR ++AN E   RL     +  LC RVMT ++I++D +D NG F   S ID++  ++++K +  P Q+  L + +RF+T H+ND STPK+++ LI
Sbjct:   10 ASCLEMIRSIIRSTADDNSKWVEIFVDFENAQPTDEEREIYNMAEEVLNDCDLVLADVSSYGNGCYAERNQLKNDSDTQALKVLMTKLEPFVARTCSYYEHVAKIEKIVPIILWELSSGPLPLEEQLANKQSIAKQFARLIGFVLDFDVVKMRTAQITNDYSYYRRAKHIVYQDFEDQGVPELPQV--------QMFLCEGNPMLKALCNGVDSYMQTHQSLPINNTTDVFVTIINVCRFMLANDECLARLTDS--SKHLCCRVMTGLVILFDHVDQNGAFVSNSSIDMRDVVRLIKLNTTPEQSDCLLAGLRFTTKHYNDSSTPKSLRHLI 331

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Fly
Match: CG32066 (gene:FBgn0052066 transcript:FBtr0076277)

HSP 1 Score: 244.588 bits (623), Expect = 5.218e-77
Identity = 138/336 (41.07%), Postives = 210/336 (62.50%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSN--------VFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MG +L LLSR      DDSN        VF+DFEN  PTE E+ +YD +   L  S+ +L  ++ Y+GA   I+EAI++  + ++  KAW  V+PL+ +LK CYE ++EL + VP+++  L   + +  +HLE++QA  KQ A+IL+F+L FD  KM +P+IQND SYYRR  SR     Q V   +   V+ EL   MSLFYA +TPMLK+++ + S++   D +  ++ TTE L TMAK+C  ++ NP+L  + I   DT ML LRVM  ++I+YD + P G F + + +D+K C+++L+     +   L +A+R++T H N E+TPK I+ L+
Sbjct:    1 MGKLLSLLSR------DDSNCCAAKSYDVFLDFENAAPTETERAVYDEVERVLRESEVVLDEIQIYRGAGKEIREAIAD-PSPEVTAKAWAAVLPLVNKLKRCYEHSMELDKIVPKLLGQLVGGKLNPTQHLETQQALVKQLAEILEFVLKFDEYKMKTPAIQNDFSYYRRIVSR-----QRVDSTENMLVSTELANRMSLFYAHATPMLKVLSEATSKF-VNDNADDVQNTTETLGTMAKVCLRMLENPKLLQQ-IEREDTKMLVLRVMVGLVILYDHVHPEGAFVRGAHVDVKGCVRLLQAQPAIKAEPLLNALRYTTKHLNGENTPKNIQRLL 322

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Fly
Match: CG32066 (gene:FBgn0052066 transcript:FBtr0076278)

HSP 1 Score: 244.588 bits (623), Expect = 5.218e-77
Identity = 138/336 (41.07%), Postives = 210/336 (62.50%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSN--------VFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MG +L LLSR      DDSN        VF+DFEN  PTE E+ +YD +   L  S+ +L  ++ Y+GA   I+EAI++  + ++  KAW  V+PL+ +LK CYE ++EL + VP+++  L   + +  +HLE++QA  KQ A+IL+F+L FD  KM +P+IQND SYYRR  SR     Q V   +   V+ EL   MSLFYA +TPMLK+++ + S++   D +  ++ TTE L TMAK+C  ++ NP+L  + I   DT ML LRVM  ++I+YD + P G F + + +D+K C+++L+     +   L +A+R++T H N E+TPK I+ L+
Sbjct:    1 MGKLLSLLSR------DDSNCCAAKSYDVFLDFENAAPTETERAVYDEVERVLRESEVVLDEIQIYRGAGKEIREAIAD-PSPEVTAKAWAAVLPLVNKLKRCYEHSMELDKIVPKLLGQLVGGKLNPTQHLETQQALVKQLAEILEFVLKFDEYKMKTPAIQNDFSYYRRIVSR-----QRVDSTENMLVSTELANRMSLFYAHATPMLKVLSEATSKF-VNDNADDVQNTTETLGTMAKVCLRMLENPKLLQQ-IEREDTKMLVLRVMVGLVILYDHVHPEGAFVRGAHVDVKGCVRLLQAQPAIKAEPLLNALRYTTKHLNGENTPKNIQRLL 322

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Zebrafish
Match: fam49al (family with sequence similarity 49 member A, like [Source:ZFIN;Acc:ZDB-GENE-040801-125])

HSP 1 Score: 278.485 bits (711), Expect = 3.848e-90
Identity = 150/328 (45.73%), Postives = 217/328 (66.16%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN++K+L +++E      + F+DFEN QPTE E  +Y+ +++ LE +  IL  L++Y GA   I+EAI N  +  LQ+KAWN V PL+ +LK  YEF++ L   +  ++  L S   +  +HLE +QA  KQFA+IL F L+FD LKM +P+IQND SYYRR  SR R   Q +    E  V +E+   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  DT++ C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R++T H ND+ST K I+AL+
Sbjct:    1 MGNLIKVLGKDLENC---PHFFLDFENAQPTEAETAVYNQVSAVLEEAHGILAELQSYNGAGQEIREAIQNPNDLQLQEKAWNAVCPLVAKLKRFYEFSLRLENALRSLLEALTSPPYAPMQHLEREQALAKQFAEILHFTLSFDELKMTNPAIQNDFSYYRRTISRNRLNNQQLEA--ENEVNNEMANRMSLFYAEATPMLKTLSNATTKFVSENKTLPIEDTTDCLSTMACVCRVMLETPEYRCRF-TNTDTMLFCMRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPSNSVEGLLNALRYTTRHLNDDSTSKQIRALL 322

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Zebrafish
Match: fam49al (family with sequence similarity 49 member A, like [Source:ZFIN;Acc:ZDB-GENE-040801-125])

HSP 1 Score: 276.944 bits (707), Expect = 1.580e-89
Identity = 152/328 (46.34%), Postives = 216/328 (65.85%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LKLL+    E +    VF+DFE+ QPTE E  +Y+ +++ LE +  IL  L++Y GA   I+EAI N  +  LQ+KAWN V PL+ +LK  YEF++ L   +  ++  L S   +  +HLE +QA  KQFA+IL F L+FD LKM +P+IQND SYYRR  SR R   Q +    E  V +E+   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  DT++ C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R++T H ND+ST K I+AL+
Sbjct:    1 MGNLLKLLA--CTELEHGPIVFLDFEHAQPTEAETAVYNQVSAVLEEAHGILAELQSYNGAGQEIREAIQNPNDLQLQEKAWNAVCPLVAKLKRFYEFSLRLENALRSLLEALTSPPYAPMQHLEREQALAKQFAEILHFTLSFDELKMTNPAIQNDFSYYRRTISRNRLNNQQLEA--ENEVNNEMANRMSLFYAEATPMLKTLSNATTKFVSENKTLPIEDTTDCLSTMACVCRVMLETPEYRCRF-TNTDTMLFCMRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPSNSVEGLLNALRYTTRHLNDDSTSKQIRALL 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Zebrafish
Match: fam49ba (family with sequence similarity 49 member Ba [Source:ZFIN;Acc:ZDB-GENE-030131-9537])

HSP 1 Score: 270.396 bits (690), Expect = 7.127e-87
Identity = 142/328 (43.29%), Postives = 216/328 (65.85%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN++K+L+R+I+   +  N F+DFEN +PTE E+ +++ +   L  +  ILQ L++Y GA   I++AI + ++  +Q++AW  VVPL+ +LK  YEF+++L +T+  ++  L S   S  +HLE +QA  +QFA+IL F L FD LKM +P+IQND SYYRR  SR R   Q  T  +   V +EL   MSLFYA +TPMLK ++ + +++ ++   +P+E TT+CL+TMA +C+ ++  PE   R  +  DTV+ CLRVM  VII+YD + P G F K+SKID+K C+K+L+         L +A+R++T H NDEST K IK ++
Sbjct:    1 MGNLIKVLTRDID--NNAGNFFLDFENAKPTEAERRVWEEVNGVLREAAIILQDLQSYSGAGEAIRQAIQHPSDERVQEQAWAAVVPLVGKLKKFYEFSLKLEDTLQNLLEYLTSSRCSPTQHLEQEQALARQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRIINQ--TAEEHNEVDNELANRMSLFYANATPMLKTLSDATTKFVSKHAELPVENTTDCLSTMASVCKVMLETPEYRSRFAS-EDTVLFCLRVMVGVIILYDYVHPAGAFVKSSKIDMKGCIKVLRYQPANSVEGLLNALRYTTKHLNDESTSKQIKNML 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Zebrafish
Match: fam49a (family with sequence similarity 49 member A [Source:ZFIN;Acc:ZDB-GENE-031002-50])

HSP 1 Score: 270.011 bits (689), Expect = 7.451e-87
Identity = 137/328 (41.77%), Postives = 210/328 (64.02%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+R IE   +  + F+DFEN QPT+ E+ +++ + + L+ S+ IL  L+ YKGA   I++AI N  +  LQ++AWN V PL+  LK  Y F+++L + +  ++  L     +  +HLE +QA  KQFA+IL F L FD LKM  P+IQND        +  RN   ++ +  E  V +E+   MSLFYAE+TPMLK ++ + + +  E+ ++P+E TT+CL+TMA +C+ ++  PE   R     DT++ C+RVM  VII+YD + PNG F K+SKID+K C+K+LK+        L +A++F+T H NDESTPK I+ ++
Sbjct:    1 MGNLLKVLTREIE---NYPHFFLDFENAQPTDCEREVWNQVNAVLQESESILSGLQAYKGAGQEIRDAIQNPNDMLLQERAWNSVCPLVIRLKKFYAFSLKLEQALQSLLESLTCPPYTPTQHLEREQALAKQFAEILHFTLRFDELKMRIPAIQNDF--SYYRRTISRNRLNNMNLDIENEVNNEMANRMSLFYAEATPMLKTLSTATTNFVTENKTLPLENTTDCLSTMASVCKVMLETPEYTSRF-NSEDTLLFCMRVMVGVIILYDHVHPNGAFNKSSKIDMKGCIKVLKDQPADNVEGLLNALKFTTKHLNDESTPKNIRTML 322

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Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+R IE   +  + F+DFEN QPT+ E+ +++ + + L+ S+ IL  L+ YKGA   I++AI N  +  LQ++AWN V PL+  LK  Y F+++L + +  ++  L     +  +HLE +QA  KQFA+IL F L FD LKM  P+IQND        +  RN   ++ +  E  V +E+   MSLFYAE+TPMLK ++ + + +  E+ ++P+E TT+CL+TMA +C+ ++  PE   R     DT++ C+RVM  VII+YD + PNG F K+SKID+K C+K+LK+        L +A++F+T H NDESTPK I+ ++
Sbjct:    1 MGNLLKVLTREIE---NYPHFFLDFENAQPTDCEREVWNQVNAVLQESESILSGLQAYKGAGQEIRDAIQNPNDMLLQERAWNSVCPLVIRLKKFYAFSLKLEQALQSLLESLTCPPYTPTQHLEREQALAKQFAEILHFTLRFDELKMRIPAIQNDF--SYYRRTISRNRLNNMNLDIENEVNNEMANRMSLFYAEATPMLKTLSTATTNFVTENKTLPLENTTDCLSTMASVCKVMLETPEYTSRF-NSEDTLLFCMRVMVGVIILYDHVHPNGAFNKSSKIDMKGCIKVLKDQPADNVEGLLNALKFTTKHLNDESTPKNIRTML 322

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Xenopus
Match: fam49b (family with sequence similarity 49 member B [Source:NCBI gene;Acc:448066])

HSP 1 Score: 280.796 bits (717), Expect = 7.133e-91
Identity = 152/328 (46.34%), Postives = 218/328 (66.46%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN++K+L+R+I+   + ++ F+DFEN QP+E EK +Y+ +   L+ ++ IL  L++Y+GA   I+EAI + T+  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R++T H NDE+T K IK ++
Sbjct:    1 MGNLIKVLTRDIDH--NAAHFFLDFENAQPSESEKEVYNQVNVVLKDAEGILDHLQSYRGAGHEIREAIQHATDEKLQEKAWAAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMR--INNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPPNSVEGLLNALRYTTKHLNDETTSKQIKTML 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Xenopus
Match: fam49b (family with sequence similarity 49 member B [Source:NCBI gene;Acc:448066])

HSP 1 Score: 276.559 bits (706), Expect = 3.504e-89
Identity = 152/328 (46.34%), Postives = 214/328 (65.24%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QP+E EK +Y+ +   L+ ++ IL  L++Y+GA   I+EAI + T+  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R++T H NDE+T K IK ++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPSESEKEVYNQVNVVLKDAEGILDHLQSYRGAGHEIREAIQHATDEKLQEKAWAAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMR--INNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPPNSVEGLLNALRYTTKHLNDETTSKQIKTML 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Xenopus
Match: fam49a (family with sequence similarity 49 member A [Source:NCBI gene;Acc:549592])

HSP 1 Score: 269.24 bits (687), Expect = 2.305e-86
Identity = 141/328 (42.99%), Postives = 209/328 (63.72%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    E     N F+DFEN QPT+ E+ +++ + + L+ S+ IL  L+ YKGA   I++AI N  +  LQ+KAWN V PL+  LK  YEF++ L + +  ++  L     +  +HLE +QA  K+FA+IL F L FD LKM +P+IQND        +  RN   ++ +  E  V +E+   MSLFYAE+TPMLK ++ + + + +++ ++PIE TT+CL+TMA +C+ ++  PE   R  T  DT+M C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+RF+T H NDEST K I+A++
Sbjct:    1 MGNLLKVLT--CTELDQGPNFFLDFENAQPTDGEREVWNQVNAVLQDSESILSDLQAYKGAGQEIRDAIQNPNDIQLQEKAWNSVCPLVVRLKRFYEFSLRLEKALQSLLESLTCPPYTPTQHLEREQALAKEFAEILHFTLRFDELKMRNPAIQNDF--SYYRRTISRNRINNMHLDIENDVNNEMANRMSLFYAEATPMLKTLSNATTSFVSDNKTLPIENTTDCLSTMASVCKVMLETPEYRSRF-TSEDTLMFCMRVMVGVIILYDHVHPVGAFCKTSKIDMKGCIKVLKEQPPDSVEGLLNALRFTTKHLNDESTSKQIRAML 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Xenopus
Match: ENSXETT00000046848.1 (uncharacterized loc548655 [Source:NCBI gene;Acc:548655])

HSP 1 Score: 268.47 bits (685), Expect = 7.807e-86
Identity = 136/329 (41.34%), Postives = 213/329 (64.74%), Query Frame = 1

Query:   70 LMGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            +MGN++K+L +++E      + F+DFEN QPTE E  +++ + S LE ++ +L  L++Y+GA   I++AI N  +  LQ++AW  V PL+ +LK  YEF++ L   +  ++  L S   +  +HLE +QA  KQFA+IL F L+FD LKM +P+IQND        +  RN   +  V  +  V +E+   MSLFYA++TPMLK ++ + +++ +E+ S+PIE TT+CL+TMA +CR ++  P    R  T  +T++ C+RVM  VII+YD + P G F KTSKID+K C+K+LK+     T  L +A+R++T H ND++T K I+AL+
Sbjct:   20 VMGNLIKVLGKDLENCP---HFFLDFENAQPTEAETAVWNQVNSVLEEAQGVLAELQSYRGAGQEIRQAIQNPLDLHLQEEAWRAVCPLVAKLKRFYEFSLRLENALHSLLEALTSPPFAPTQHLEREQALAKQFAEILHFTLSFDELKMTNPAIQNDF--SYYRRTVSRNRLNNFQVDADSDVNNEMANRMSLFYADATPMLKTLSNATTKFVSENKSLPIEDTTDCLSTMACVCRVMLETPGYRSRF-TSNETLLFCMRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPSTSTEGLLNALRYTTRHLNDDTTSKQIRALL 342

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Xenopus
Match: fam49b (family with sequence similarity 49 member B [Source:NCBI gene;Acc:448066])

HSP 1 Score: 260.381 bits (664), Expect = 3.234e-82
Identity = 146/321 (45.48%), Postives = 210/321 (65.42%), Query Frame = 1

Query:   40 FSISKIV*SFLMGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRF 1002
            FSI ++     MGN++K+L+R+I+   + ++ F+DFEN QP+E EK +Y+ +   L+ ++ IL  L++Y+GA   I+EAI + T+  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R+
Sbjct:   21 FSIFRLA---GMGNLIKVLTRDIDH--NAAHFFLDFENAQPSESEKEVYNQVNVVLKDAEGILDHLQSYRGAGHEIREAIQHATDEKLQEKAWAAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMR--INNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPPNSVEGLLNALRY 333

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Mouse
Match: Fam49b (family with sequence similarity 49, member B [Source:MGI Symbol;Acc:MGI:1923520])

HSP 1 Score: 275.404 bits (703), Expect = 8.597e-89
Identity = 151/328 (46.04%), Postives = 215/328 (65.55%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K I++++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIRSML 323

[Close]

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K I++++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIRSML 323

[Close]

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K I++++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIRSML 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Mouse
Match: Fam49a (family with sequence similarity 49, member A [Source:MGI Symbol;Acc:MGI:1261783])

HSP 1 Score: 275.018 bits (702), Expect = 1.176e-88
Identity = 145/328 (44.21%), Postives = 211/328 (64.33%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+R IE   +  + F+DFEN QPTE E+ I++ I++ L+ S+ IL  L+ YKGA   I++AI N  +  LQ+KAWN V PL+  LK  YEF+I L + +  ++  L     +  +HLE +QA  K+FA+IL F L FD LKM +P+IQND        +  RN   ++ +  E  V +E+   MSLFYAE+TPMLK ++ +   + +E+ ++PIE TT+CL+TM  +C+ ++  PE   R  T  +T+M C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+RF+T H NDEST K I+A++
Sbjct:    1 MGNLLKVLTREIE---NYPHFFLDFENAQPTEGEREIWNQISAVLQDSESILTDLQAYKGAGPEIRDAIQNPNDIQLQEKAWNAVCPLVVRLKRFYEFSIRLEKALQSLLESLTCPPYTPTQHLEREQALAKEFAEILHFTLRFDELKMRNPAIQNDF--SYYRRTISRNRINNMHLDIENEVNNEMANRMSLFYAEATPMLKTLSNATMHFVSENKTLPIENTTDCLSTMTSVCKVMLETPEYRSRF-TSEETLMFCMRVMVGVIILYDHVHPVGAFCKTSKIDMKGCIKVLKEQAPDSVEGLLNALRFTTKHLNDESTSKQIRAML 322

[Close]

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+R IE   +  + F+DFEN QPTE E+ I++ I++ L+ S+ IL  L+ YKGA   I++AI N  +  LQ+KAWN V PL+  LK  YEF+I L + +  ++  L     +  +HLE +QA  K+FA+IL F L FD LKM +P+IQND        +  RN   ++ +  E  V +E+   MSLFYAE+TPMLK ++ +   + +E+ ++PIE TT+CL+TM  +C+ ++  PE   R  T  +T+M C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+RF+T H NDEST K I+A++
Sbjct:    1 MGNLLKVLTREIE---NYPHFFLDFENAQPTEGEREIWNQISAVLQDSESILTDLQAYKGAGPEIRDAIQNPNDIQLQEKAWNAVCPLVVRLKRFYEFSIRLEKALQSLLESLTCPPYTPTQHLEREQALAKEFAEILHFTLRFDELKMRNPAIQNDF--SYYRRTISRNRINNMHLDIENEVNNEMANRMSLFYAEATPMLKTLSNATMHFVSENKTLPIENTTDCLSTMTSVCKVMLETPEYRSRF-TSEETLMFCMRVMVGVIILYDHVHPVGAFCKTSKIDMKGCIKVLKEQAPDSVEGLLNALRFTTKHLNDESTSKQIRAML 322

[Close]

BLAST of Family with sequence similarity 49 member A vs. UniProt/SwissProt
Match: sp|Q9NUQ9|CYRIB_HUMAN (CYFIP-related Rac1 interactor B OS=Homo sapiens OX=9606 GN=CYRIB PE=1 SV=1)

HSP 1 Score: 276.174 bits (705), Expect = 2.983e-88
Identity = 152/328 (46.34%), Postives = 215/328 (65.55%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K IK+++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSML 323

[Close]

BLAST of Family with sequence similarity 49 member A vs. UniProt/SwissProt
Match: sp|Q2KJI3|CYRIB_BOVIN (CYFIP-related Rac1 interactor B OS=Bos taurus OX=9913 GN=CYRIB PE=2 SV=1)

HSP 1 Score: 276.174 bits (705), Expect = 2.983e-88
Identity = 152/328 (46.34%), Postives = 215/328 (65.55%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K IK+++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSML 323

[Close]

BLAST of Family with sequence similarity 49 member A vs. UniProt/SwissProt
Match: sp|Q921M7|CYRIB_MOUSE (CYFIP-related Rac1 interactor B OS=Mus musculus OX=10090 GN=Cyrib PE=1 SV=1)

HSP 1 Score: 275.404 bits (703), Expect = 6.013e-88
Identity = 151/328 (46.04%), Postives = 215/328 (65.55%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPTE EK IY+ +   L+ ++ IL+ L++Y+GA   I+EAI +  +  LQ+KAW  VVPL+ +LK  YEF+  L   +  ++  L S   S  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  +TV  CLRVM  VII+YD + P G F KTSKID+K C+K+LK+        L +A+R++T H NDE+T K I++++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIRSML 323

[Close]

BLAST of Family with sequence similarity 49 member A vs. UniProt/SwissProt
Match: sp|Q5R6L2|CYRIA_PONAB (CYFIP-related Rac1 interactor A OS=Pongo abelii OX=9601 GN=CYRIA PE=2 SV=1)

HSP 1 Score: 275.018 bits (702), Expect = 7.710e-88
Identity = 145/328 (44.21%), Postives = 211/328 (64.33%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+R IE   +  + F+DFEN QPTE E+ I++ I++ L+ S+ IL  L+ YKGA   I++AI N  +  LQ+KAWN V PL+  LK  YEF+I L + +  ++  L     +  +HLE +QA  K+FA+IL F L FD LKM +P+IQND        +  RN   ++ +  E  V +E+   MSLFYAE+TPMLK ++ +   + +E+ ++PIE TT+CL+TM  +C+ ++  PE   R  T  +T+M C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+RF+T H NDEST K I+A++
Sbjct:    1 MGNLLKVLTREIE---NYPHFFLDFENAQPTEGEREIWNQISAVLQDSESILADLQAYKGAGPEIRDAIQNPNDIQLQEKAWNAVCPLVVRLKRFYEFSIRLEKALQSLLESLTCPPYTPTQHLEREQALAKEFAEILHFTLRFDELKMRNPAIQNDF--SYYRRTISRNRINNMHLDIENEVNNEMANRMSLFYAEATPMLKTLSNATMHFVSENKTLPIENTTDCLSTMTSVCKVMLETPEYRSRF-TSEETLMFCMRVMVGVIILYDHVHPVGAFCKTSKIDMKGCIKVLKEQAPDSVEGLLNALRFTTKHLNDESTSKQIRAML 322

[Close]

BLAST of Family with sequence similarity 49 member A vs. UniProt/SwissProt
Match: sp|Q9H0Q0|CYRIA_HUMAN (CYFIP-related Rac1 interactor A OS=Homo sapiens OX=9606 GN=CYRIA PE=2 SV=1)

HSP 1 Score: 275.018 bits (702), Expect = 7.710e-88
Identity = 145/328 (44.21%), Postives = 211/328 (64.33%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+R IE   +  + F+DFEN QPTE E+ I++ I++ L+ S+ IL  L+ YKGA   I++AI N  +  LQ+KAWN V PL+  LK  YEF+I L + +  ++  L     +  +HLE +QA  K+FA+IL F L FD LKM +P+IQND        +  RN   ++ +  E  V +E+   MSLFYAE+TPMLK ++ +   + +E+ ++PIE TT+CL+TM  +C+ ++  PE   R  T  +T+M C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+RF+T H NDEST K I+A++
Sbjct:    1 MGNLLKVLTREIE---NYPHFFLDFENAQPTEGEREIWNQISAVLQDSESILADLQAYKGAGPEIRDAIQNPNDIQLQEKAWNAVCPLVVRLKRFYEFSIRLEKALQSLLESLTCPPYTPTQHLEREQALAKEFAEILHFTLRFDELKMRNPAIQNDF--SYYRRTISRNRINNMHLDIENEVNNEMANRMSLFYAEATPMLKTLSNATMHFVSENKTLPIENTTDCLSTMTSVCKVMLETPEYRSRF-TSEETLMFCMRVMVGVIILYDHVHPVGAFCKTSKIDMKGCIKVLKEQAPDSVEGLLNALRFTTKHLNDESTSKQIRAML 322

[Close]

BLAST of Family with sequence similarity 49 member A vs. TrEMBL
Match: A0A068Y603 (Protein FAM49B OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000486100 PE=4 SV=1)

HSP 1 Score: 338.576 bits (867), Expect = 6.263e-109
Identity = 168/343 (48.98%), Postives = 241/343 (70.26%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXX---XXNYGQDVTV----------VKE--EAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGNI++LL+   EE KDD+++F+DFENCQP++ E  ++  I +KL  + DIL  ++NY GAA  I+ AI  YT++  Q+ AW  +VPL+ +L+ICY+F + LA+TVPR++  LCS E ++ EHLES+QA FKQFA+ILDFI+ FD++KM  PSIQND S+YRR   R     ++ + +            +++  E ++DE C  MSLFYAE+TPMLKLI+R  ++    D  +P++ T+ECLA MA ICRG++  P L  R +T  DT+ML LRVMT VII+YD +DP GVF+KTSK+D+K+C+++LKE        L +AI++ST+HF DE+TP+ IK L+
Sbjct:    1 MGNIIRLLTGRFEEIKDDADIFVDFENCQPSDEEYNLWMEINTKLAHTDDILMIVQNYPGAATQIRSAIERYTDDAAQEAAWEALVPLVHQLRICYDFGVYLAQTVPRLLHALCSDELTVWEHLESQQALFKQFAEILDFIMQFDNIKMTKPSIQNDFSFYRRLRQRRRPAVDFARQIAAPCNVDGAEPFLRQGIEELSDECCSKMSLFYAEATPMLKLISRYATQCHMVDAMIPMDVTSECLAAMAHICRGLLVKPSLRSR-VTRDDTLMLLLRVMTGVIILYDHIDPYGVFRKTSKLDVKSCVRLLKEQNPKSVQCLLNAIKYSTLHFTDETTPRVIKQLL 342

[Close]

BLAST of Family with sequence similarity 49 member A vs. TrEMBL
Match: A0A068WPI3 (Protein FAM49B OS=Echinococcus granulosus OX=6210 GN=EgrG_000486100 PE=4 SV=1)

HSP 1 Score: 338.191 bits (866), Expect = 1.542e-108
Identity = 168/343 (48.98%), Postives = 241/343 (70.26%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXX---XXNYGQDVTV----------VKE--EAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGNI++LL+   EE KDD+++F+DFENCQP++ E  ++  I +KL  + DIL  + NY GAA  I+ AI  YT++  Q+ AW  +VPL+ +L+ICY+F + LA+TVPR++  LCS E ++ EHLES+QA FKQFA+ILDFI+ FD++KM  PSIQND S+YRR   R     ++ + ++           +++  E ++DE C  MSLFYAE+TPMLKLI+R  ++    D  +P++ T+ECLA MA ICRG++  P L  R +T  DT+ML LRVMT VII+YD +DP GVF+KTSK+D+K+C+++LKE        L +AI++ST+HF DE+TP+ IK L+
Sbjct:    1 MGNIIRLLTGRFEEIKDDADIFVDFENCQPSDEEYDLWMEINTKLAHTDDILMIVRNYPGAAAQIRSAIERYTDDAAQEAAWEALVPLVHQLRICYDFGVYLAQTVPRLLHALCSDELTVWEHLESQQALFKQFAEILDFIMQFDNIKMTKPSIQNDFSFYRRLRQRRRPAVDFSRQISAPCNVDGAEPFLRQGIEELSDECCSKMSLFYAEATPMLKLISRYATQCHMVDAMIPMDVTSECLAAMAHICRGLLVKPSLRSR-VTRDDTLMLLLRVMTGVIILYDHIDPYGVFRKTSKLDVKSCVRLLKEQNPKSVQCLLNAIKYSTLHFTDETTPRVIKQLL 342

[Close]

BLAST of Family with sequence similarity 49 member A vs. TrEMBL
Match: A0A0V0J7Z3 (Protein FAM49B OS=Schistocephalus solidus OX=70667 GN=FA49B PE=4 SV=1)

HSP 1 Score: 331.643 bits (849), Expect = 2.427e-107
Identity = 168/334 (50.30%), Postives = 239/334 (71.56%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXX------XNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGNIL+LL+   EE KDD ++F+DFENCQP+E E  ++  I  KL  + D+L  ++NY GAA  I+ AI  +++ + Q +AW  + PL+++L+ CY+F +ELA+T+PR++  LCS E ++ EHLES+QA FKQFA+ILDFI+ FD LKM  PSIQND S++RR  SRR           D  + + + +TDE C  MSLFYAE+TPMLKL+ R  ++++  + S+    T+ECLA MA ICRG+++ P L  R +T  DT+MLCLRVMT VII+YD +DP+GVF+KTSK+D+K+C+++LKE        L +AI++ST+HFNDE+TP+ IK L+
Sbjct:    1 MGNILRLLTSRSEEIKDDVDIFVDFENCQPSEEEYDLWLEINEKLAHTDDVLHLVQNYPGAAAEIRAAIERFSDANAQLQAWKALSPLVQQLRFCYDFGVELAQTIPRLLHALCSDELTVWEHLESQQALFKQFAEILDFIMKFDDLKMTKPSIQNDFSFFRRLRSRRRVNPPLYQVSDDGCMRRADDLTDEYCSKMSLFYAEATPMLKLVGRYTTQYQLMESSITCNVTSECLAAMAHICRGLLSKPCLRGR-VTKADTLMLCLRVMTGVIILYDHVDPSGVFRKTSKLDVKSCVRLLKEQNPKSVECLLNAIKYSTLHFNDETTPRVIKHLL 333

[Close]

BLAST of Family with sequence similarity 49 member A vs. TrEMBL
Match: A0A5K3EFZ7 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 330.102 bits (845), Expect = 1.680e-106
Identity = 167/342 (48.83%), Postives = 235/342 (68.71%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXX----------XXXXXNYGQDVTVV----KEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGNI++ L+   EE KDD ++F+DFENCQP+  E  ++  I +KL  ++D+L  + NY GAA  I+ AI   ++   Q+ AW  +VPL+ +L+ICY+F + LAETVPR++  LCS E ++ EHLES+QA FKQFA+ILDFI+ FD++KM  PSIQND S+YRR             +   Y  D T      + E ++DE C  MSLFYAE+TPMLKLI+R  ++    DV++P++ T+ECLA MA ICRG++  P +  R +T  DT+ML LRVMT VII+YD +DP GVF+KTSK+D+K+C+++LKE        L +AI++ST+HF DE+TP+ IK L+
Sbjct:    1 MGNIIRFLTSRSEEIKDDFDIFVDFENCQPSNEEYDLWLEINAKLAHAEDVLLLVRNYPGAAPQIRTAIERCSDEAAQEAAWRALVPLVHQLRICYDFGVYLAETVPRLLYALCSDELTVWEHLESQQALFKQFAEILDFIMQFDNIKMTKPSIQNDFSFYRRLRQRRRPVTDPSQQNVPYCVDNTEAFLRQEMEELSDECCSKMSLFYAEATPMLKLISRYATQCHVVDVTIPMDVTSECLAAMAHICRGLLVKPGMRSR-VTRDDTLMLLLRVMTGVIILYDHIDPYGVFRKTSKLDVKSCVRLLKEQNPKNVQCLLNAIKYSTLHFTDETTPRVIKQLL 341

[Close]

BLAST of Family with sequence similarity 49 member A vs. TrEMBL
Match: A0A1S3JJY7 (protein FAM49B OS=Lingula unguis OX=7574 GN=LOC106173906 PE=4 SV=1)

HSP 1 Score: 298.516 bits (763), Expect = 1.452e-94
Identity = 153/328 (46.65%), Postives = 226/328 (68.90%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LKLLS++   TK D  +F+DFEN Q TE E P+Y  +   L+ +  IL+ L+ Y+GA+  I+EAISN +N+DLQ+KAW  V PL+ +LK  YEF+I+L   VP+++  LCS +++  EHLE++QA FKQFA ILDF L FD LKM +P+IQND SYYRR  SR +   +  + +  + V++E+   MSLFYA +TPMLK ++ + +++ +E+  +P+E TT+CL+TMA ICR ++ NPE + R     +T++ C+RVM  VII+YD + P G F K S ID+K+ +K+LK+        L +A+R++T H ND++TPK  K L+
Sbjct:    1 MGNLLKLLSKDYTPTKVD--IFVDFENAQATEHEFPLYTKVEEVLKDACHILEELQQYRGASSEIREAISNPSNDDLQEKAWEAVRPLVLQLKRYYEFSIQLENIVPQLLGKLCSNDKTAKEHLETQQALFKQFAQILDFTLKFDDLKMNNPAIQNDFSYYRRTLSRMKMTNEHSSNMDNQEVSNEIANRMSLFYAHATPMLKTLSDTTTKFVSENKDIPVENTTDCLSTMASICRVMIENPEYYTRFQN-EETLLFCMRVMVGVIILYDHVHPVGAFAKNSHIDVKSSIKVLKDQHPVNLEALLNALRYTTKHLNDDATPKGTKTLL 325

[Close]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Cavefish
Match: fam49al (protein FAM49A-like [Source:NCBI gene;Acc:103035846])

HSP 1 Score: 276.559 bits (706), Expect = 2.348e-89
Identity = 149/328 (45.43%), Postives = 217/328 (66.16%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN++K+L +++E      + F+DFEN QPTE E  +++ +++ LE +  IL  L++Y GA   I+EAI N  +  LQ+KAWN V PL+ +LK  YEF++ L   +  ++  L S   +  +HLE +QA  KQFA+IL F L+FD LKM +P+IQND SYYRR  SR R   Q +    E  V +E+   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  DT++ C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R++T H ND+ST K I+AL+
Sbjct:    1 MGNLIKVLGKDLENC---PHFFLDFENAQPTEAETAVWNQVSAVLEEAHGILAELQSYNGAGQEIREAIQNPNDLQLQEKAWNAVCPLVAKLKRFYEFSLRLENALRSLLEALTSPPYAPMQHLEREQALAKQFAEILHFTLSFDELKMTNPAIQNDFSYYRRTISRNRLNNQQLEA--ENEVNNEMANRMSLFYAEATPMLKTLSNATTKFVSENKTLPIEDTTDCLSTMACVCRVMLETPEYRCRF-TNTDTMLFCMRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPSNSVEGLLNALRYTTRHLNDDSTSKQIRALL 322

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Cavefish
Match: fam49al (protein FAM49A-like [Source:NCBI gene;Acc:103035846])

HSP 1 Score: 274.248 bits (700), Expect = 1.565e-88
Identity = 150/328 (45.73%), Postives = 216/328 (65.85%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    E +    VF+DFE+ QPTE E  +++ +++ LE +  IL  L++Y GA   I+EAI N  +  LQ+KAWN V PL+ +LK  YEF++ L   +  ++  L S   +  +HLE +QA  KQFA+IL F L+FD LKM +P+IQND SYYRR  SR R   Q +    E  V +E+   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  DT++ C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R++T H ND+ST K I+AL+
Sbjct:    1 MGNLLKVLA--CAELEHGQIVFLDFEHAQPTEAETAVWNQVSAVLEEAHGILAELQSYNGAGQEIREAIQNPNDLQLQEKAWNAVCPLVAKLKRFYEFSLRLENALRSLLEALTSPPYAPMQHLEREQALAKQFAEILHFTLSFDELKMTNPAIQNDFSYYRRTISRNRLNNQQLEA--ENEVNNEMANRMSLFYAEATPMLKTLSNATTKFVSENKTLPIEDTTDCLSTMACVCRVMLETPEYRCRF-TNTDTMLFCMRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPSNSVEGLLNALRYTTRHLNDDSTSKQIRALL 323

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Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    E +    VF+DFE+ QPTE E  +++ +++ LE +  IL  L++Y GA   I+EAI N  +  LQ+KAWN V PL+ +LK  YEF++ L   +  ++  L S   +  +HLE +QA  KQFA+IL F L+FD LKM +P+IQND SYYRR  SR R   Q +    E  V +E+   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  DT++ C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R++T H ND+ST K I+AL+
Sbjct:    1 MGNLLKVLA--CAELEHGQIVFLDFEHAQPTEAETAVWNQVSAVLEEAHGILAELQSYNGAGQEIREAIQNPNDLQLQEKAWNAVCPLVAKLKRFYEFSLRLENALRSLLEALTSPPYAPMQHLEREQALAKQFAEILHFTLSFDELKMTNPAIQNDFSYYRRTISRNRLNNQQLEA--ENEVNNEMANRMSLFYAEATPMLKTLSNATTKFVSENKTLPIEDTTDCLSTMACVCRVMLETPEYRCRF-TNTDTMLFCMRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPSNSVEGLLNALRYTTRHLNDDSTSKQIRALL 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Cavefish
Match: fam49ba (protein FAM49B-like [Source:NCBI gene;Acc:103039003])

HSP 1 Score: 272.322 bits (695), Expect = 1.077e-87
Identity = 144/328 (43.90%), Postives = 221/328 (67.38%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN++K+L+R+I+   +  N F+DFEN QPTE E+  ++ +++ LE +  ILQ L++Y GA   I++AI    +  +Q+KAW+ VVPL+ +LK  YEF+++L  T+  ++  L S   S  +HLE +QA  +QFA+IL F L FD LKM +P+IQND SYYRR  SR R    ++   +E  V +EL   MSLFYA +TPMLK ++ + +++ +++  +PIE TT+CL+TMA +C+ ++  PE   R  +  DTV+ CLRVM  VII+YD + P G F K+SKID+K C+K+L++    +   L +A+R++T H NDE+T K IK+++
Sbjct:    1 MGNLIKVLTRDID--NNAGNFFLDFENAQPTEAERQQWEQVSAVLEEAMSILQDLQSYSGAGEAIRQAIQQPNDESVQEKAWSSVVPLVGKLKKFYEFSVKLEGTLHGLLGFLTSARCSPTQHLEQEQALARQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRI--NNLATEEENEVNNELANRMSLFYANATPMLKTLSDATTKFVSDNTDLPIENTTDCLSTMASVCKVMLETPEYRSRFAS-EDTVLFCLRVMVGVIILYDYVHPAGAFVKSSKIDMKGCIKVLRDQPPNRVEGLLNALRYTTKHLNDETTSKQIKSML 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Cavefish
Match: fam49bb (protein FAM49B [Source:NCBI gene;Acc:103032810])

HSP 1 Score: 256.529 bits (654), Expect = 1.495e-81
Identity = 144/329 (43.77%), Postives = 210/329 (63.83%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQS-INEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + + + N F+DFEN QPTE E+  +D +   L+ ++ IL  L+ YKGA   I+EAI N  +  LQ +AW  VVPL+ +LK  YEF+  L   +  ++  L +   S   +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  +R R    +V    E  V +EL   +SLFYA++TPMLK ++   +++ +E+ ++PIE TT+ L+TMA +C+ ++  PE   R  +   TV  CLRVM  VII+YD + P G F K+SKID+K C+K+L++        L +A+R++T H NDEST KTIK+++
Sbjct:    1 MGNLLKVLT--CTDLEQEPNFFLDFENAQPTEAERETWDEVDVVLKDAQVILDELQAYKGAGQEIREAIQNPNDEALQDQAWAAVVPLVGKLKKFYEFSQRLEAALHSLLRALTNETHSDPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLNRMR--INNVPAEGENEVNNELANRISLFYADATPMLKTLSDGTTKFVSENKNLPIENTTDVLSTMASVCKVMLETPEYRSRF-SSEATVSFCLRVMVGVIILYDYVHPVGAFAKSSKIDMKGCIKVLRDQPPNSVEGLLNALRYTTKHLNDESTAKTIKSML 324

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003669.1 (pep scaffold:Pmarinus_7.0:GL479009:168657:184855:-1 gene:ENSPMAG00000003343.1 transcript:ENSPMAT00000003669.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 264.618 bits (675), Expect = 1.629e-85
Identity = 147/330 (44.55%), Postives = 210/330 (63.64%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXX--NYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + +   N F+DFEN QPT+ E+  +  + S L+ ++ +L  L+ Y GA   I+EAISN  N   Q+KAWN V PL+ +LK  +EF+  L   +  ++  L     +  +HLE +QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SR R  N G DV    E  V +E+   MSLFYAE+TPMLK ++   +R+  E  S+P+E TT+CL+TMA++C+ ++  PE   R  +  +TV  CLRVM  VII+YD + P G F K+SKID+K C+K+LK+        L +A+R++T H N+E+T K IKA++
Sbjct:    1 MGNLLKVLT--CTDLEQGPNFFLDFENAQPTDNEQQTWMSVGSVLQGTRSVLSELQEYCGAGNEIREAISNPGNEIFQEKAWNAVCPLVSKLKRFFEFSQRLDRALQSLLVALTCPPLTSMQHLEREQALAKQFAEILHFTLQFDELKMTNPAIQNDFSYYRRTLSRMRINNMGSDV----EMEVNNEMANRMSLFYAEATPMLKTLSDGTTRFVQEHKSLPLENTTDCLSTMARVCKVMLETPEYRKRFAS-EETVFFCLRVMVGVIILYDHVHPVGAFAKSSKIDMKGCIKVLKDQPANSVEGLLNALRYNTKHLNEETTSKQIKAML 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Sea Lamprey
Match: fam49al (family with sequence similarity 49 member A, like [Source:ZFIN;Acc:ZDB-GENE-040801-125])

HSP 1 Score: 220.32 bits (560), Expect = 4.719e-69
Identity = 114/269 (42.38%), Postives = 169/269 (62.83%), Query Frame = 1

Query:  250 GAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            G      +AISN  + +LQ+KAW  V PL+ +LK  YEF++ LAE +  ++  L     +  +HLE +QA  KQFA+IL F L FD LKM +P+IQND        +  RN   +   + E  V +E+   MSLFYAE+TPMLK ++   +++ +E+ ++PIE TT+CL+TMA +C+ ++  PE   R  T  +TV  CLRVM  VII+YD + P G F ++SKID+K C+K+LKE        L +A+R++T H NDE+T K +K+++
Sbjct:    1 GGGDAGPQAISNSNDVELQEKAWKAVCPLVAKLKRYYEFSLCLAEALRSLLTALTCPPCTPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDF--SYYRRTLSRNRINNTYQIAENEVNNEMANRMSLFYAEATPMLKTLSDVTTKFVSENKTLPIENTTDCLSTMASVCKVMLETPEYRSRF-TNEETVSFCLRVMVGVIILYDHVHPVGAFARSSKIDMKGCIKVLKEQPPNSVEGLLNALRYTTRHLNDENTSKQVKSML 266

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Nematostella
Match: EDO39426 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA43])

HSP 1 Score: 286.96 bits (733), Expect = 8.424e-94
Identity = 151/328 (46.04%), Postives = 220/328 (67.07%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+L+LLSR+   T    ++F+DFEN QPTE E+ +Y+ +   L+ +  +L+ L +Y GA+  I+EAISN  N DLQ+ AW EVVPL+ +LK  YE+A EL   +P+++  LC+   +  EHLE  QA  KQFA+IL F L FD LKM +P+IQND SYYRR  SRR+    D     E  V++E+   MSLFYA  TP+LK+++ + +++ +E+ S+PIE TT+CL+T+A +CR ++ N  +  R     +T++ CLRVM  VII+YD + P G F KTS IDIK+ +K+L++        L +A+R++T H NDE+TPK I+AL+
Sbjct:    1 MGNLLRLLSRDDPGTGK-VDIFLDFENAQPTETEREVYEVVKGVLDSADRMLEELRSYPGASQAIREAISNPMNEDLQEIAWREVVPLVGKLKTFYEYATELESVLPQLLHALCAGPDTPIEHLEKHQALAKQFAEILHFTLKFDDLKMTNPNIQNDFSYYRRTLSRRKMANSDD---DEVVVSNEMANRMSLFYAYPTPLLKILSDATTKFVSENKSLPIENTTDCLSTLANLCRTMIENENISSRFQNEEETILFCLRVMVGVIILYDHVHPVGAFAKTSNIDIKSSIKVLRDQPQGTVDGLLNALRYTTKHLNDETTPKNIRALL 324

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Nematostella
Match: EDO45302 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSY6])

HSP 1 Score: 116.316 bits (290), Expect = 3.354e-31
Identity = 57/122 (46.72%), Postives = 80/122 (65.57%), Query Frame = 1

Query:  151 NCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLK 516
            + QPTE E+ +Y+ +   L+ +  +L+ L +Y GA+  I+EAISN  N DLQ+ AW EVVPL+ +LK  YE+A EL   +P+++  LC+   +  EHLE  QA  KQFA+IL F L FD LK
Sbjct:    7 DAQPTETEREVYEVVKGVLDSADRMLEELRSYPGASQAIREAISNPMNEDLQEIAWREVVPLVGKLKTFYEYATELESVLPQLLHALCAGPDTPIEHLEKHQALAKQFAEILHFTLKFDDLK 128

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Medaka
Match: fam49al (protein FAM49A [Source:NCBI gene;Acc:101166565])

HSP 1 Score: 275.789 bits (704), Expect = 3.630e-89
Identity = 149/328 (45.43%), Postives = 217/328 (66.16%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN++K+L +++E      + F+DFEN QPTE E  +++ +++ LE +  IL  L++Y GA   I+EAI N  +  LQ+KAWN V PL+ +LK  YEF++ L   +  ++  L S   +  +HLE +QA  KQFA+IL F L+FD LKM +P+IQND SYYRR  SR R   Q +    E  V +E+   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  DT++ C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R++T H ND+ST K I+AL+
Sbjct:    1 MGNLIKVLGKDLENC---PHFFLDFENAQPTEAETAVWNQVSAVLEEAHGILAELQSYNGAGQEIREAIQNPGDLALQEKAWNAVCPLVAKLKRFYEFSLRLENALRSLLEALTSPPYAPMQHLEREQALAKQFAEILHFTLSFDELKMTNPAIQNDFSYYRRTISRNRLNNQQLEA--ENEVNNEMANRMSLFYAEATPMLKTLSNATTKFVSENKTLPIEDTTDCLSTMACVCRVMLETPEYRCRF-TNTDTMLFCMRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPSNSVEGLLNALRYTTRHLNDDSTSKQIRALL 322

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Medaka
Match: fam49al (protein FAM49A [Source:NCBI gene;Acc:101166565])

HSP 1 Score: 273.092 bits (697), Expect = 5.374e-88
Identity = 150/328 (45.73%), Postives = 216/328 (65.85%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    E +    VF+DFE+ QPTE E  +++ +++ LE +  IL  L++Y GA   I+EAI N  +  LQ+KAWN V PL+ +LK  YEF++ L   +  ++  L S   +  +HLE +QA  KQFA+IL F L+FD LKM +P+IQND SYYRR  SR R   Q +    E  V +E+   MSLFYAE+TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +CR ++  PE   R  T  DT++ C+RVM  VII+YD + P G F KTSKID+K C+K+LKE        L +A+R++T H ND+ST K I+AL+
Sbjct:    1 MGNLLKVLA--CAELEHGPIVFLDFEHAQPTEAETAVWNQVSAVLEEAHGILAELQSYNGAGQEIREAIQNPGDLALQEKAWNAVCPLVAKLKRFYEFSLRLENALRSLLEALTSPPYAPMQHLEREQALAKQFAEILHFTLSFDELKMTNPAIQNDFSYYRRTISRNRLNNQQLEA--ENEVNNEMANRMSLFYAEATPMLKTLSNATTKFVSENKTLPIEDTTDCLSTMACVCRVMLETPEYRCRF-TNTDTMLFCMRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKEQPSNSVEGLLNALRYTTRHLNDDSTSKQIRALL 323

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Medaka
Match: fam49a (family with sequence similarity 49 member A [Source:NCBI gene;Acc:101164615])

HSP 1 Score: 271.937 bits (694), Expect = 3.114e-87
Identity = 139/328 (42.38%), Postives = 210/328 (64.02%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+R IE   +  + F+DFEN Q TE E+ ++D + + L+ S+ IL  L+ YKGA   I++AI N  +  LQ++AWN V PL+ +LK  Y F++ L E +  ++  L     +  +HLE +QA  KQFA+IL F L FD LKM  P+IQND        +  RN   ++ +  E  V +E+   MSLFYAE+TPMLK ++ + + + +E+ ++P+E TT+CL+TMA +C+ ++  PE   R     DT++ C+RVM  VII+YD + PNG F K+SKID+K C+K+LK+        L +A++F+T H NDESTPK I+ ++
Sbjct:    1 MGNLLKVLTREIE---NYPSFFLDFENAQATEGEREVWDQVNAVLQDSESILTGLQAYKGAGQEIRDAIQNPNDMTLQERAWNSVCPLVIKLKKFYSFSLRLEEALRSLLTSLTCPPLTPTQHLEREQALAKQFAEILHFTLRFDELKMRIPAIQNDF--SYYRRTISRNRINNMNLDIENEVNNEMANRMSLFYAEATPMLKTLSTATTNFVSENKTLPLENTTDCLSTMASVCKVMLETPEYSSRF-NSEDTLLFCMRVMVGVIILYDHVHPNGAFNKSSKIDMKGCIKVLKDQPADTVEGLLNALKFTTKHLNDESTPKNIRTML 322

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BLAST of Family with sequence similarity 49 member A vs. Ensembl Medaka
Match: fam49bb (protein FAM49B [Source:NCBI gene;Acc:101167518])

HSP 1 Score: 266.929 bits (681), Expect = 1.279e-85
Identity = 150/330 (45.45%), Postives = 216/330 (65.45%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCS--YEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN+LK+L+    + + + N F+DFEN QPT+ E+ ++  + + L+ S+ IL  L+ YKGA   I+EAI N ++  LQ+ AW  VVPL+ +LK  YEF+  L   +  ++  L S  Y  S  +HLE +QA  KQFA+ILDF L FD LKM +P+IQND SYYRR  SR R    +V    E  V +EL   +SLFYA++TPMLK ++ + +++ +E+ ++PIE TT+CL+TMA +C+ ++  PE   R I    TV  CLRVM  VII+YD + P G F K+SKID+K C+K+LK+        L +A+R++T H NDEST KTIK+++
Sbjct:    1 MGNLLKVLT--CTDLEQEPNFFLDFENAQPTDAEREVWGQVDAVLKDSEGILDELQAYKGAGQEIREAIQNPSDEALQELAWAAVVPLVWKLKKFYEFSQRLEAALHSLLGALTSETYSDST-QHLEREQALAKQFAEILDFTLRFDELKMTNPAIQNDFSYYRRTLSRMR--INNVPAELENEVNNELANRISLFYADATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCKVMLETPEYRGRFINE-STVSFCLRVMVGVIILYDYVHPVGAFAKSSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDESTNKTIKSML 324

[Close]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Medaka
Match: fam49ba (protein FAM49B [Source:NCBI gene;Acc:101156770])

HSP 1 Score: 263.848 bits (673), Expect = 1.755e-84
Identity = 136/334 (40.72%), Postives = 212/334 (63.47%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVK------EEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIRFSTVHFNDESTPKTIKALI 1056
            MGN++K+L+R+I+   +  NVF+DFEN QP+  E  I++ +   LE ++ +L  L+ Y+GA   I++AI +  + D+Q+KAW+ VVPL+ +LK  YEF+ +L  ++  ++ VL     +  + LE KQA  +QFA IL F L FD LKM +P+IQND SY          Y + ++ ++         V +EL  +MSLFYA +TPMLK ++ + S++ +++  VPIE TT+CL+TMA +C+ ++  PE   R  T  +TV+ CLRVM  VII+YD + P G F KTS ID+K C+++L+E        L +A+R++T H NDE+T K I+ ++
Sbjct:    1 MGNLIKVLTRDID--NNAGNVFLDFENAQPSPSETDIWETVKQTLEEAQVVLNDLQAYRGAGEEIRQAIQSPADEDVQEKAWSAVVPLVAKLKTFYEFSQKLESSLRSLLDVLTRSGTTPTQQLEQKQALARQFAHILHFTLRFDELKMTNPAIQNDFSY----------YRRTISRMRINNLPVSGEVNNELANHMSLFYANATPMLKTLSNATSKFVSDNPDVPIENTTDCLSTMACVCKVMLETPEYRSRF-TSEETVLFCLRVMVGVIILYDHVHPAGAFVKTSNIDMKGCIRVLREQAPSSVEGLLNALRYTTKHLNDETTSKQIRNML 321

[Close]

BLAST of Family with sequence similarity 49 member A vs. Planmine SMEST
Match: SMESG000040316.1 (SMESG000040316.1)

HSP 1 Score: 616.305 bits (1588), Expect = 0.000e+0
Identity = 309/309 (100.00%), Postives = 309/309 (100.00%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIR 999
            MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLSYYRRCCSRRRNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIR
Sbjct:    1 MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLSYYRRCCSRRRNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIR 309

[Close]

BLAST of Family with sequence similarity 49 member A vs. Planmine SMEST
Match: SMESG000040316.1 (SMESG000040316.1)

HSP 1 Score: 605.134 bits (1559), Expect = 0.000e+0
Identity = 308/322 (95.65%), Postives = 309/322 (95.96%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFE-------------NCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIR 999
            MGNILKLLSRNIEETKDDSNVFIDFE             +CQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLSYYRRCCSRRRNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIR
Sbjct:    1 MGNILKLLSRNIEETKDDSNVFIDFESNQFFYFIIYIFKDCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLSYYRRCCSRRRNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIR 322

[Close]

BLAST of Family with sequence similarity 49 member A vs. Planmine SMEST
Match: SMESG000040316.1 (SMESG000040316.1)

HSP 1 Score: 499.59 bits (1285), Expect = 7.803e-172
Identity = 266/322 (82.61%), Postives = 267/322 (82.92%), Query Frame = 1

Query:   73 MGNILKLLSRNIEETKDDSNVFIDFE-------------NCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLXXXXXXXXXXXNYGQDVTVVKEEAVTDELCGNMSLFYAESTPMLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIR 999
            MGNILKLLSRNIEETKDDSNVFIDFE             +CQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLSYYRRCCSRRRNYGQD                                          VSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIR
Sbjct:    1 MGNILKLLSRNIEETKDDSNVFIDFESNQFFYFIIYIFKDCQPTEVEKPIYDHIASKLERSKDILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAIELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMMSPSIQNDLSYYRRCCSRRRNYGQD------------------------------------------VSVPIETTTECLATMAKICRGIVANPELHHRLITPPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQTSTLFSAIR 280

The following BLAST results are available for this feature:

BLAST of Family with sequence similarity 49 member A vs. Ensembl Human
BLAST of Family with sequence similarity 49 member A vs. Ensembl Celegans
BLAST of Family with sequence similarity 49 member A vs. Ensembl Fly
BLAST of Family with sequence similarity 49 member A vs. Ensembl Zebrafish
BLAST of Family with sequence similarity 49 member A vs. Ensembl Xenopus
BLAST of Family with sequence similarity 49 member A vs. Ensembl Mouse
BLAST of Family with sequence similarity 49 member A vs. UniProt/SwissProt
BLAST of Family with sequence similarity 49 member A vs. TrEMBL
BLAST of Family with sequence similarity 49 member A vs. Ensembl Cavefish
BLAST of Family with sequence similarity 49 member A vs. Ensembl Sea Lamprey
BLAST of Family with sequence similarity 49 member A vs. Ensembl Yeast
BLAST of Family with sequence similarity 49 member A vs. Ensembl Nematostella
BLAST of Family with sequence similarity 49 member A vs. Ensembl Medaka
BLAST of Family with sequence similarity 49 member A vs. Planmine SMEST

BLAST of Family with sequence similarity 49 member A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
FAM49B	6.213e-89	46.34	family with sequence similarity 49 member B [Sourc...	[more]
FAM49B	6.213e-89	46.34	family with sequence similarity 49 member B [Sourc...	[more]
FAM49B	6.213e-89	46.34	family with sequence similarity 49 member B [Sourc...	[more]
FAM49B	6.213e-89	46.34	family with sequence similarity 49 member B [Sourc...	[more]
FAM49B	6.213e-89	46.34	family with sequence similarity 49 member B [Sourc...	[more]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
R07G3.8	9.085e-45	31.02	pep chromosome:WBcel235:II:7618238:7620513:-1 gene...	[more]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
CG32066	5.218e-77	41.07	gene:FBgn0052066 transcript:FBtr0076277	[more]
CG32066	5.218e-77	41.07	gene:FBgn0052066 transcript:FBtr0076278	[more]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
fam49al	3.848e-90	45.73	family with sequence similarity 49 member A, like ...	[more]
fam49al	1.580e-89	46.34	family with sequence similarity 49 member A, like ...	[more]
fam49ba	7.127e-87	43.29	family with sequence similarity 49 member Ba [Sour...	[more]
fam49a	7.451e-87	41.77	family with sequence similarity 49 member A [Sourc...	[more]
fam49a	7.451e-87	41.77	family with sequence similarity 49 member A [Sourc...	[more]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
fam49b	7.133e-91	46.34	family with sequence similarity 49 member B [Sourc...	[more]
fam49b	3.504e-89	46.34	family with sequence similarity 49 member B [Sourc...	[more]
fam49a	2.305e-86	42.99	family with sequence similarity 49 member A [Sourc...	[more]
ENSXETT00000046848.1	7.807e-86	41.34	uncharacterized loc548655 [Source:NCBI gene;Acc:54...	[more]
fam49b	3.234e-82	45.48	family with sequence similarity 49 member B [Sourc...	[more]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Fam49b	8.597e-89	46.04	family with sequence similarity 49, member B [Sour...	[more]
Fam49b	8.597e-89	46.04	family with sequence similarity 49, member B [Sour...	[more]
Fam49b	8.597e-89	46.04	family with sequence similarity 49, member B [Sour...	[more]
Fam49a	1.176e-88	44.21	family with sequence similarity 49, member A [Sour...	[more]
Fam49a	1.176e-88	44.21	family with sequence similarity 49, member A [Sour...	[more]

BLAST of Family with sequence similarity 49 member A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9NUQ9\|CYRIB_HUMAN	2.983e-88	46.34	CYFIP-related Rac1 interactor B OS=Homo sapiens OX...	[more]
sp\|Q2KJI3\|CYRIB_BOVIN	2.983e-88	46.34	CYFIP-related Rac1 interactor B OS=Bos taurus OX=9...	[more]
sp\|Q921M7\|CYRIB_MOUSE	6.013e-88	46.04	CYFIP-related Rac1 interactor B OS=Mus musculus OX...	[more]
sp\|Q5R6L2\|CYRIA_PONAB	7.710e-88	44.21	CYFIP-related Rac1 interactor A OS=Pongo abelii OX...	[more]
sp\|Q9H0Q0\|CYRIA_HUMAN	7.710e-88	44.21	CYFIP-related Rac1 interactor A OS=Homo sapiens OX...	[more]

BLAST of Family with sequence similarity 49 member A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A068Y603	6.263e-109	48.98	Protein FAM49B OS=Echinococcus multilocularis OX=6...	[more]
A0A068WPI3	1.542e-108	48.98	Protein FAM49B OS=Echinococcus granulosus OX=6210 ...	[more]
A0A0V0J7Z3	2.427e-107	50.30	Protein FAM49B OS=Schistocephalus solidus OX=70667...	[more]
A0A5K3EFZ7	1.680e-106	48.83	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A1S3JJY7	1.452e-94	46.65	protein FAM49B OS=Lingula unguis OX=7574 GN=LOC106...	[more]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
fam49al	2.348e-89	45.43	protein FAM49A-like [Source:NCBI gene;Acc:10303584...	[more]
fam49al	1.565e-88	45.73	protein FAM49A-like [Source:NCBI gene;Acc:10303584...	[more]
fam49al	1.565e-88	45.73	protein FAM49A-like [Source:NCBI gene;Acc:10303584...	[more]
fam49ba	1.077e-87	43.90	protein FAM49B-like [Source:NCBI gene;Acc:10303900...	[more]
fam49bb	1.495e-81	43.77	protein FAM49B [Source:NCBI gene;Acc:103032810]	[more]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000003669.1	1.629e-85	44.55	pep scaffold:Pmarinus_7.0:GL479009:168657:184855:-...	[more]
fam49al	4.719e-69	42.38	family with sequence similarity 49 member A, like ...	[more]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Family with sequence similarity 49 member A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO39426	8.424e-94	46.04	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45302	3.354e-31	46.72	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Family with sequence similarity 49 member A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
fam49al	3.630e-89	45.43	protein FAM49A [Source:NCBI gene;Acc:101166565]	[more]
fam49al	5.374e-88	45.73	protein FAM49A [Source:NCBI gene;Acc:101166565]	[more]
fam49a	3.114e-87	42.38	family with sequence similarity 49 member A [Sourc...	[more]
fam49bb	1.279e-85	45.45	protein FAM49B [Source:NCBI gene;Acc:101167518]	[more]
fam49ba	1.755e-84	40.72	protein FAM49B [Source:NCBI gene;Acc:101156770]	[more]

BLAST of Family with sequence similarity 49 member A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000040316.1	0.000e+0	100.00	SMESG000040316.1	[more]
SMESG000040316.1	0.000e+0	95.65	SMESG000040316.1	[more]
SMESG000040316.1	7.803e-172	82.61	SMESG000040316.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30007853 ID=SMED30007853|Name=Family with sequence similarity 49 member A|organism=Schmidtea mediterranea sexual|type=transcript|length=1436bp
TTTAGGAATATTTAAGTGTTGAATTTATAAAACTATAAATTTAGTATTAG
TAAAATTGTATAATCGTTTCTAATGGGAAACATTCTTAAGTTATTAAGCA
GGAATATAGAAGAAACAAAGGACGATTCTAATGTCTTCATAGATTTTGAA
AATTGTCAACCAACGGAAGTTGAAAAACCAATTTATGATCATATTGCGTC
TAAGTTAGAAAGATCTAAAGATATTTTACAACGATTGGAAAATTATAAAG
GTGCTGCCATTGTTATTAAAGAAGCTATAAGTAATTATACTAACAATGAT
TTACAAAAAAAAGCTTGGAATGAGGTTGTTCCACTTATGAAAGAATTAAA
AATATGTTATGAATTCGCTATAGAATTAGCTGAAACGGTTCCAAGAGTAA
TGGCAGTCCTGTGTTCATATGAACAGTCGATCAATGAGCATCTGGAATCG
AAACAAGCTACTTTCAAACAATTTGCTGATATATTGGATTTTATTTTAAA
TTTTGACAGTTTAAAAATGATGAGCCCATCGATTCAAAATGATTTAAGTT
ATTATCGACGATGTTGTTCTAGGCGAAGAAATTACGGACAAGATGTCACA
GTAGTCAAAGAAGAAGCAGTGACAGATGAATTATGTGGAAATATGTCTTT
GTTTTATGCCGAGTCAACTCCAATGTTAAAGCTGATAACTCGTTCTATTT
CTCGATGGCGAGCTGAGGATGTTAGTGTCCCAATAGAAACAACAACTGAA
TGCTTGGCAACTATGGCTAAAATCTGTCGTGGAATCGTTGCTAATCCGGA
GTTGCACCATAGACTTATAACACCTCCAGATACGGTTATGTTGTGTTTGC
GAGTTATGACTGCAGTCATTATTATTTACGATTTATTGGATCCTAATGGA
GTTTTTAAAAAAACATCTAAAATCGATATTAAAGCTTGTCTCAAAATATT
AAAAGAACATGGTCTGCCTCAAACCTCCACTTTATTCAGTGCTATTAGAT
TTTCAACAGTTCATTTTAATGACGAGTCAACTCCAAAAACAATCAAGGCG
CTAATAATTGAAGCTACTGCATAAAGTCTTGAATTTATGTATATTAAAAA
TCAAACTATTATTATGATATATATTTGCTCAATTATCTTATGAGATTTCG
CATATGTTCTTCCTATTGATATTTTCTTCAGGAATTTTTTAATGTCTAAA
ATTTGATAATAATTGTTGGGTTTTTCTAGAAAATTTAAAAATTTCAATTT
TTAAAAAAATAATTTAATTCAACCATAATTTTTGTCTAGAAATTTTGTAT
ATTTTATTAACTAAATCGTTTGGTTATTATTGTATTAACTGATTTAACAT
TTTATAATTGCATGATTTTGTTTATTAATTTTTAATTTGATTTTGTCTAG
ATTTTCCACTATATTTTTAATAAAGATTGATTGTTA

protein sequence of SMED30007853-orf-1

>SMED30007853-orf-1 ID=SMED30007853-orf-1|Name=SMED30007853-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=334bp
MGNILKLLSRNIEETKDDSNVFIDFENCQPTEVEKPIYDHIASKLERSKD
ILQRLENYKGAAIVIKEAISNYTNNDLQKKAWNEVVPLMKELKICYEFAI
ELAETVPRVMAVLCSYEQSINEHLESKQATFKQFADILDFILNFDSLKMM
SPSIQNDLSYYRRCCSRRRNYGQDVTVVKEEAVTDELCGNMSLFYAESTP
MLKLITRSISRWRAEDVSVPIETTTECLATMAKICRGIVANPELHHRLIT
PPDTVMLCLRVMTAVIIIYDLLDPNGVFKKTSKIDIKACLKILKEHGLPQ
TSTLFSAIRFSTVHFNDESTPKTIKALIIEATA*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0045580	regulation of T cell differentiation
GO:0048538	thymus development
GO:0002576	platelet degranulation

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000020	protonephridia
PLANA:0000026	gut
PLANA:0000070	intestinal phagocyte
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR039789	FAM49
IPR009828	DUF1394

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding

Vocabulary: **cellular component**
Term	Definition
GO:0005576	extracellular region
GO:0005929	cilium
GO:0016020	membrane
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular exosome

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR009828	Protein of unknown function DUF1394	PFAM	PF07159	DUF1394	coord: 20..325 e-value: 4.8E-112 score: 374.1
IPR039789	Protein FAM49	PANTHER	PTHR12422	UNCHARACTERIZED	coord: 1..328

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Family with sequence similarity 49 member A

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Owlery

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