Myotubularin-related protein 2

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            GENI     +VT     T    G L +TNYRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S N+ LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  +T+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:    9 GENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF-----------------KSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAEL 535          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            GENI     +VT     T    G L +TNYRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S N+ LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  +T+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:    9 GENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF-----------------KSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAEL 535          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            GENI     +VT     T    G L +TNYRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S N+ LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  +T+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:    9 GENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF-----------------KSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAEL 535          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            GENI     +VT     T    G L +TNYRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S N+ LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  +T+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:    9 GENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF-----------------KSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAEL 535          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            GENI     +VT     T    G L +TNYRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S N+ LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  +T+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:   81 GENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF-----------------KSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAEL 607          

Query:  150 NLLQEVYDFK--CGENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEK-----------GDGN-CLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHK--EPGYRNSVLSDEYQRQLI-ESNNWRISKVNHNFEVCETYPDEVAVPKDVSDET---ITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQR-RTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLR 1745
            +++QE  D K    E+++  E NVT F    K   G +++T YR++F               + +  K ++   L++P+G +   EK           GD N   TI CKD+R         S+        L +Y  P S N+ +FA VH     +  + G++      EY+R  I  S  W+   +N +++  ETYP    +P    +E    +    +FR+K R PVL WI+  T A+++R SQP TG++ KR+  DER+L +I +ANA    L I+DARP +NA+ N A+GGG E    Y +    FLNI NIHV+R+S+++L     P+ D   ++KAL+E+KWLN+++ IL G++     +++++ SVL+HCSDGWDRTAQ+TSL  + LD Y+RTI GF  LI+KEW   GHK  +R G   + +          ER+P+F+QF DC+WQI +QF  AFEF ++ LI ++D +Y+  +G FL+NSE+ R +  +    T+SFW +V  + +K+RNP+F       ++V+     L  +  W  YY R
Sbjct:   18 SMIQESIDLKLLAAESLIWTEKNVTYFGPLGKFP-GKIVITRYRMVFL--------------VGDGGKMYEQWKLDIPLGQVSRIEKVGRKTTSVAKRGDDNYGFTIYCKDYRVYRFTCNPASSDRKNVCDSLNRYAFPLSHNLPMFASVHAAETPRLMKDGWKIYSAEKEYERLGIPNSRLWKEVDINKDYKFSETYPRTFVIPTVSWEEGKPFVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISGKRSAEDERHLTNIMNANANCRELLILDARPAVNAKLNKAKGGGYEEN--YVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSILEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDNYSD-------GERSPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFLYNSEKIRLKDKKCDETTISFWSYVLENKKKFRNPMFKHG--KSNKVINVNPSLCGLHVWIDYYAR 545          

Query:  348 EFKSLDLNLPVGFIQEFEKGD----GNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENI-KLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQR---TGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTP 1664
            E  S +L L  G I   EKG     G  L I+CK F+ +TL +  D +  D ++ L ++   P S N+ +L AF + + +    G+R    + E  RQ I  + W  S +N  + +C+TYP+++  P   S   +  +C+FR++ R PVL + H  T+A L R +QP TG +  R   DE+ ++ +  AN  ++ L ++D RP +NA  N  +G G E +  Y+++ + F +I NIHVMR S  +L D      D + + K LE + WL ++R ++  SL +AE I+   S +VHCSDGWDRT+Q+ +L QL+LDPY+RTI GFQ LI+K+WL  GHK   R    G L +E G         E +PIF Q++DC+WQI QQ   AF+FNE++LI++ + VYS  FG F+ N ++ RR   +  +T S W  +++  + Y NP ++P
Sbjct:   42 ENGSKELWLATGLISSVEKGTLTAAGCMLVIRCKHFQVITLLISRDKSCQDLYETL-QRAAKPVSVNVTELLAFENREPVEDVRGWRRLDWNSEMTRQGITKSQWTESNINEGYTICDTYPNKLWFPTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLTGFS-ARCVEDEKLMELVGKANTNSDNLFLVDTRPRVNAMVNKVQGKGFEDERNYSNMRFHFFDIENIHVMRASQARLLDAVTKCRDVTEYWKTLEASGWLKHVRSVVECSLFLAESISRGTSCVVHCSDGWDRTSQVVALCQLLLDPYYRTIHGFQVLIEKDWLGFGHKFDDRCGHVGALNDEAG--------KEVSPIFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDLNLSKRTKSLWTWMDARHDDYMNPFYSP 478          

Query:  348 EFKSLDLNLPVGFIQEFEKGD----GNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENI-KLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQR---TGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFP-QYRLPCIRFWKSYYLR 1745
            E  S +L L  G I   EKG     G  L I+CK F+ +TL +  D +  D ++ L ++   P S N+ +L AF + + +    G+R    + E  RQ I  + W  S +N  + +C+TYP+++  P   S   +  +C+FR++ R PVL + H  T+A L R +QP TG +  R   DE+ ++ +  AN  ++ L ++D RP +NA  N  +G G E +  Y+++ + F +I NIHVMR S  +L D      D + + K LE + WL ++R ++  SL +AE I+   S +VHCSDGWDRT+Q+ +L QL+LDPY+RTI GFQ LI+K+WL  GHK   R    G L +E G         E +PIF Q++DC+WQI QQ   AF+FNE++LI++ + VYS  FG F+ N ++ RR   +  +T S W  +++  + Y NP ++P   + H  L     R      W + Y R
Sbjct:  148 ENGSKELWLATGLISSVEKGTLTAAGCMLVIRCKHFQVITLLISRDKSCQDLYETL-QRAAKPVSVNVTELLAFENREPVEDVRGWRRLDWNSEMTRQGITKSQWTESNINEGYTICDTYPNKLWFPTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLTGFS-ARCVEDEKLMELVGKANTNSDNLFLVDTRPRVNAMVNKVQGKGFEDERNYSNMRFHFFDIENIHVMRASQARLLDAVTKCRDVTEYWKTLEASGWLKHVRSVVECSLFLAESISRGTSCVVHCSDGWDRTSQVVALCQLLLDPYYRTIHGFQVLIEKDWLGFGHKFDDRCGHVGALNDEAG--------KEVSPIFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDLNLSKRTKSLWTWMDARHDDYMNPFYSP---TAHVALLDLDTRAARFTVWTAMYNR 609          

Query:  348 EFKSLDLNLPVGFIQEFEKGD----GNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENI-KLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQR---TGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFP-QYRLPCIRFWKSYYLR 1745
            E  S +L L  G I   EKG     G  L I+CK F+ +TL +  D +  D ++ L ++   P S N+ +L AF + + +    G+R    + E  RQ I  + W  S +N  + +C+TYP+++  P   S   +  +C+FR++ R PVL + H  T+A L R +QP TG +  R   DE+ ++ +  AN  ++ L ++D RP +NA  N  +G G E +  Y+++ + F +I NIHVMR S  +L D      D + + K LE + WL ++R ++  SL +AE I+   S +VHCSDGWDRT+Q+ +L QL+LDPY+RTI GFQ LI+K+WL  GHK   R    G L +E G         E +PIF Q++DC+WQI QQ   AF+FNE++LI++ + VYS  FG F+ N ++ RR   +  +T S W  +++  + Y NP ++P   + H  L     R      W + Y R
Sbjct:  148 ENGSKELWLATGLISSVEKGTLTAAGCMLVIRCKHFQVITLLISRDKSCQDLYETL-QRAAKPVSVNVTELLAFENREPVEDVRGWRRLDWNSEMTRQGITKSQWTESNINEGYTICDTYPNKLWFPTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLTGFS-ARCVEDEKLMELVGKANTNSDNLFLVDTRPRVNAMVNKVQGKGFEDERNYSNMRFHFFDIENIHVMRASQARLLDAVTKCRDVTEYWKTLEASGWLKHVRSVVECSLFLAESISRGTSCVVHCSDGWDRTSQVVALCQLLLDPYYRTIHGFQVLIEKDWLGFGHKFDDRCGHVGALNDEAG--------KEVSPIFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDLNLSKRTKSLWTWMDARHDDYMNPFYSP---TAHVALLDLDTRAARFTVWTAMYNR 609          

Query:  348 EFKSLDLNLPVGFIQEFEKGD----GNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQR---TGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTP 1664
            E  S +L L  G I   EKG     G  L I+CK F+ +TL +  D +  D ++ L ++   P +   +L AF + + +    G+R    + E  RQ I  + W  S +N  + +C+TYP+++  P   S   +  +C+FR++ R PVL + H  T+A L R +QP TG +  R   DE+ ++ +  AN  ++ L ++D RP +NA  N  +G G E +  Y+++ + F +I NIHVMR S  +L D      D + + K LE + WL ++R ++  SL +AE I+   S +VHCSDGWDRT+Q+ +L QL+LDPY+RTI GFQ LI+K+WL  GHK   R    G L +E G         E +PIF Q++DC+WQI QQ   AF+FNE++LI++ + VYS  FG F+ N ++ RR   +  +T S W  +++  + Y NP ++P
Sbjct:   42 ENGSKELWLATGLISSVEKGTLTAAGCMLVIRCKHFQVITLLISRDKSCQDLYETL-QRAAKPVNVT-ELLAFENREPVEDVRGWRRLDWNSEMTRQGITKSQWTESNINEGYTICDTYPNKLWFPTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLTGFS-ARCVEDEKLMELVGKANTNSDNLFLVDTRPRVNAMVNKVQGKGFEDERNYSNMRFHFFDIENIHVMRASQARLLDAVTKCRDVTEYWKTLEASGWLKHVRSVVECSLFLAESISRGTSCVVHCSDGWDRTSQVVALCQLLLDPYYRTIHGFQVLIEKDWLGFGHKFDDRCGHVGALNDEAG--------KEVSPIFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDLNLSKRTKSLWTWMDARHDDYMNPFYSP 476          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDA--MHKEPGYRNSVLSD---EYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLR 1745
            GE    ++N+VT          G L +TNYRL             +F  +P   +E   + +++P+G I   EK  G          + I CKD R++    K  ++S     + L+    P S + +LFAF H  A  ++   G+    + +   E +R  + ++ WR +K+N ++ +C++YP   AVPK  SD+ +    QFR++ R PVL W++P T+AT+TR SQP  G++ KRN  DE YL  I +ANA ++ LTI+DARP  NA AN A+GGG ES++ Y ++  +FL+I NIHVMRES+RK+ + C+P  D+S W  A++ T WL +IR IL G++ + +K+ +   SV+VHCSDGWDRTAQ+T+L  L+LDP++RT+RGF+ LI+KEWL  GHK  QR        G   +    ++R+P+FLQFID VWQ++QQF  AFEFNE FLI ++D +YS  FG FL N+E +R   ++  KT S W H+NS +++Y NPLF         VL P   +  +R WK  Y R
Sbjct:   52 GEEDQDQKNDVTYVCPYRGPVFGALTITNYRL-------------YFRSLPLRDQE-PPVVVDVPLGVIARVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQR-------IGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLYCR 565          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDA--MHKEPGYRNSVLSD---EYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLR 1745
            GE    ++N+VT          G L +TNYRL             +F  +P   +E   + +++P+G I   EK  G          + I CKD R++    K  ++S     + L+    P S + +LFAF H  A  ++   G+    + +   E +R  + ++ WR +K+N ++ +C++YP   AVPK  SD+ +    QFR++ R PVL W++P T+AT+TR SQP  G++ KRN  DE YL  I +ANA ++ LTI+DARP  NA AN A+GGG ES++ Y ++  +FL+I NIHVMRES+RK+ + C+P  D+S W  A++ T WL +IR IL G++ + +K+ +   SV+VHCSDGWDRTAQ+T+L  L+LDP++RT+RGF+ LI+KEWL  GHK  QR        G   +    ++R+P+FLQFID VWQ++QQF  AFEFNE FLI ++D +YS  FG FL N+E +R   ++  KT S W H+NS +++Y NPLF         VL P   +  +R WK  Y R
Sbjct:   52 GEEDQDQKNDVTYVCPYRGPVFGALTITNYRL-------------YFRSLPLRDQE-PPVVVDVPLGVIARVEKIGGATSRGENSYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAAANSVNGNGGWDGWAVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQR-------IGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLYCR 565          

Query:  183 GENIVKEENNVTLFD-FSTKGQN-GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFE-KGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAF---VHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPK-PDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTP-ADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD 1784
            G +++K+  NV + D ++TK    G L LT   L+F   +SN                 ++  L++ V  I++      G+ L I+CK F SVT  +  DS   D +  LL K   P S N KL+ F    + D   K  G+    L  E++  L+ +  W +  +N  +E+C+TYP ++ VPK+ +   + ++ +FR+K R PVL ++H + KA++ R SQP +G +  R   DE+ L++I+  N+  + + ++D RP INA AN A G G E++  Y +I + FL I NIHV R S++K+ + C  K P  S +  ALE + WL +IR IL  S  +A  ++   SV+VHCSDGWDRTAQ+ SL QLML+PY+RTI+GFQ LI+K+WL  GHK S+R G +          +   E +PIF QF+DC WQ+  Q   AFEFNE+FL+ L D V+S  FG F+ N E+ R   ++  +T S W ++ + + +Y NPL+ P  DE+    L PQ    CI+FW+  Y R       ++P+ D
Sbjct:   74 GNSVLKKVENVRMIDRYNTKNPTVGTLYLTATHLIFVEPDSNK----------------ETWILHMHVASIEKLPLSTTGSPLLIRCKTFLSVTFVIPKDSECHDVYTSLL-KLFQPVSIN-KLYCFNYQPNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLH-NNKASICRCSQPLSGFS-ARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHI---------QTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLYKPNVDEAIKANLAPQ----CIKFWRGMYSRFESGIHPREPLGD 582          

Query:  192 IVKEENNVTLFDFSTKGQN-GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFE-KGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVH---FDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPK-PDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTP-ADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD 1784
            + K EN   +  ++TK    G L LT   L+F   +SN                 ++  L++ V  I++      G+ L I+CK F SVT  +  DS   D +  LL K   P S N KL+ F +    D   K  G+    L  E++  L+ +  W +  +N  +E+C+TYP ++ VPK+ +   + ++ +FR+K R PVL ++H + KA++ R SQP +G +  R   DE+ L++I+  N+  + + ++D RP INA AN A G G E++  Y +I + FL I NIHV R S++K+ + C  K P  S +  ALE + WL +IR IL  S  +A  ++   SV+VHCSDGWDRTAQ+ SL QLML+PY+RTI+GFQ LI+K+WL  GHK S+R G +          +   E +PIF QF+DC WQ+  Q   AFEFNE+FL+ L D V+S  FG F+ N E+ R   ++  +T S W ++ + + +Y NPL+ P  DE+    L PQ    CI+FW+  Y R       ++P+ D
Sbjct:    6 LAKVENVRMIDRYNTKNPTVGTLYLTATHLIFVEPDSNK----------------ETWILHMHVASIEKLPLSTTGSPLLIRCKTFLSVTFVIPKDSECHDVYTSLL-KLFQPVSIN-KLYCFNYQPNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLH-NNKASICRCSQPLSGFS-ARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHI---------QTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLYKPNVDEAIKANLAPQ----CIKFWRGMYSRFESGIHPREPLGD 510          

Query:  411 GNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVH---FDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPK-PDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTP-ADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD 1784
            G+ L I+CK F SVT  +  DS   D +  LL K   P S N KL+ F +    D   K  G+    L  E++  L+ +  W +  +N  +E+C+TYP ++ VPK+ +   + ++ +FR+K R PVL ++H + KA++ R SQP +G +  R   DE+ L++I+  N+  + + ++D RP INA AN A G G E++  Y +I + FL I NIHV R S++K+ + C  K P  S +  ALE + WL +IR IL  S  +A  ++   SV+VHCSDGWDRTAQ+ SL QLML+PY+RTI+GFQ LI+K+WL  GHK S+R G +          +   E +PIF QF+DC WQ+  Q   AFEFNE+FL+ L D V+S  FG F+ N E+ R   ++  +T S W ++ + + +Y NPL+ P  DE+    L PQ    CI+FW+  Y R       ++P+ D
Sbjct:   15 GSPLLIRCKTFLSVTFVIPKDSECHDVYTSLL-KLFQPVSIN-KLYCFNYQPNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLH-NNKASICRCSQPLSGFS-ARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHI---------QTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLYKPNVDEAIKANLAPQ----CIKFWRGMYSRFESGIHPREPLGD 460          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLR--HYLQSRSQDPIAD-YSRILSRR----KRIFQTQL-NRQPESDEETNIAQP 1877
            G + +TNYRL F + +S         E P        + LN+P+G I   EK  G          L I CKD R++   LK + +S     +++ KY  P S  ++LFAF+  +  ++E G+      +EY+RQ + +N WR++ +N N+E+C+TYP  + VP   +++ +     FR++ R PV+ W H +  A +TR SQP  G++ KRN+ DERYL  I++AN    L TI DARP +NA AN A GGG E  + Y +    FL+I NIHVMRES++KL D+ YP  + S+W  +LE T WL +I+ +L G++ VA+K++S  SV+VHCSDGWDRTAQ+TSL  LMLD Y+RT+RGFQ L++KEW+  GHK + R G      G  +   Q  +R+PIFLQFIDCVWQ+T+QF  AFEFNE+ L+ ++D +YS  FG FL+N E  R +N V TKT+S W ++NSD   Y NP +TP      RVL+P   +  +  W +YY+R    +Q + Q P+   Y  +L+ R    K++ + QL +  P S   TN + P
Sbjct:   94 GKVFITNYRLYFKNTDS---------ETP--------VTLNIPLGVISRVEKMGGASSRGENSYGLEITCKDMRNLRFALKQEGHSRRDIFEIIFKYAFPLSHGMQLFAFLSQEK-YEENGWNVYEALEEYRRQGLPNNEWRVTFINKNYELCDTYPTILVVPYKATEDDLRKVATFRSRCRIPVMSWFHKENHAVITRCSQPLVGMSGKRNKDDERYLDLIREANGTTKL-TIYDARPNVNAVANKATGGGYEGDDAYQNAELVFLDIHNIHVMRESLKKLKDIVYPNVEESHWLSSLESTHWLEHIKLVLSGAIQVADKVSSGSSVMVHCSDGWDRTAQLTSLSMLMLDSYYRTLRGFQVLMEKEWISFGHKFASRIG-----HGDKNHADQ--DRSPIFLQFIDCVWQMTKQFPTAFEFNERLLVVILDHLYSCRFGTFLYNCESVRDSNNVRTKTVSLWSYINSDTSLYINPFYTPESS---RVLYPVASMRHLELWVTYYIRWNPRIQHQQQSPVEQRYKELLALRDQYLKKLEELQLSDSAPSSTHLTNSSTP 623          

Query:  249 GLLMLTNYRLLFWSYNSNS-FGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEK-----GDGNC-LTIKCKDFRSVTLKLKNDSNSVDR-FDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            G L +TNYRL F   +    FG                  L+LP+G +   EK     G G+    + CKD R++    K   +S+ +   ++L K+  P S N+ LFAF  +  +  E G++      E +RQ + + +WRISK+N ++E+C++YP  + VP  ++D+ +     FR K R PVL WIHP+++A + RSSQP  G   +R + DE+ L++I DANA ++ L I DARP +NA AN  +GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + S+W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  +MLD ++RTIRGFQ L++KEWL  GH+  QR G      G  + T    +R+PIFLQFIDCVWQ+T+QF AAFEFNE FLI ++D +YS LFG FL NSEQQR   E+  +T+S W  VNS +E++ NPL+     S H VLFP   +  ++ W SYY+R   + R Q+P+   Y  +L++R  +
Sbjct:   80 GSLTVTNYRLFFRCTDREPVFG------------------LDLPLGVLSRVEKIGAATGRGDVSYGLACKDMRNLRFVHKEPDDSLKKSVFEVLMKFAFPVSNNMSLFAF-EYKQVFPENGWKVYDPLAECKRQGLPNESWRISKLNDHYELCDSYPATLVVPVTITDDELRRVSSFRAKGRIPVLSWIHPESQAAVVRSSQPMVGQNGRRCKEDEKLLQAIMDANAQSHKLFIFDARPSVNAAANKMKGGGFESEDAYQNAELVFLDIHNIHVMRESLRKLKEVVYPNIEESHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLALIMLDSHYRTIRGFQILVEKEWLSFGHRFQQRVG-----HGDKNHTD--VDRSPIFLQFIDCVWQMTRQFPAAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRLKEEIPKRTVSLWSFVNSQLEEFVNPLYV--HYSSH-VLFPTVGIRHLQLWVSYYIRWNPRMRPQEPVHQRYKELLAKRAEL 583          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEK-------GDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPI 1778
            G L +T+++L F S   +S               F  LD+NL  G +   E         D   L I CKD R+     K +  S     K+L KY  P S N+ LFAF + +    E G++      EY+RQ + + +W ISKVN  +EVCETYP  + +P +V+++ +     FR K RFPVL WIHP+++A + R  QP  G + +R   DERYL++I DANA ++ L I DAR    A  N A+ GG E+++ Y ++  +FL IPNIHVMRES+RKL ++ YP  D  +W   ++ T WL Y+R +L G++ +A++I S + SV+VHCSDGWDRTAQ+TSL  LMLD ++R+++GFQ L++KEWL  GH+ + R        G        SER+P+F+QFIDCVWQ+T+QF +AFEFNE FLI ++D ++S LFG FL+NSEQ+R + EVY KT+S W +VNS IE++ NPL+   +   H VL+P   L  +  W SYY+R   + R Q PI
Sbjct:   93 GTLTITDFKLYFKSLTRDS--------------PF-VLDVNL--GAVSRLESIAVQSHGDDTQGLEIVCKDLRTPRFAYKKEGQSNLEMFKILSKYAFPLSHNLPLFAFKYRETF-PEDGWKIYDPVAEYKRQGLPNESWIISKVNSGYEVCETYPALLVLPSNVTEDELKRVAAFRAKRRFPVLSWIHPESQAAIVRCGQPQVGPSDRRCREDERYLQTILDANAQSHKLCIFDARQSTVADTNKAKDGGYENESFYINVELNFLEIPNIHVMRESLRKLKEVVYPAIDQQHWFSNVDATHWLEYVRLLLAGAVRIADRIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDAHYRSLKGFQVLLEKEWLSFGHRFASRV-------GHGDGNHANSERSPLFVQFIDCVWQMTRQFPSAFEFNELFLITVLDHLFSCLFGTFLYNSEQERVSKEVYNKTVSLWSYVNSQIEEFTNPLYVNYE---HHVLYPIASLRHLELWVSYYVRWNPRMRPQVPI 582          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEK-------GDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPI 1778
            G L +T+++L F S   +S               F  LD+NL  G +   E         D   L I CKD R+     K +  S     K+L KY  P S N+ LFAF + +    E G++      EY+RQ + + +W ISKVN  +EVCETYP  + +P +V+++ +     FR K RFPVL WIHP+++A + R  QP  G + +R   DERYL++I DANA ++ L I DAR    A  N A+ GG E+++ Y ++  +FL IPNIHVMRES+RKL ++ YP  D  +W   ++ T WL Y+R +L G++ +A++I S + SV+VHCSDGWDRTAQ+TSL  LMLD ++R+++GFQ L++KEWL  GH+ + R        G        SER+P+F+QFIDCVWQ+T+QF +AFEFNE FLI ++D ++S LFG FL+NSEQ+R + EVY KT+S W +VNS IE++ NPL+   +   H VL+P   L  +  W SYY+R   + R Q PI
Sbjct:  115 GTLTITDFKLYFKSLTRDS--------------PF-VLDVNL--GAVSRLESIAVQSHGDDTQGLEIVCKDLRTPRFAYKKEGQSNLEMFKILSKYAFPLSHNLPLFAFKYRETF-PEDGWKIYDPVAEYKRQGLPNESWIISKVNSGYEVCETYPALLVLPSNVTEDELKRVAAFRAKRRFPVLSWIHPESQAAIVRCGQPQVGPSDRRCREDERYLQTILDANAQSHKLCIFDARQSTVADTNKAKDGGYENESFYINVELNFLEIPNIHVMRESLRKLKEVVYPAIDQQHWFSNVDATHWLEYVRLLLAGAVRIADRIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDAHYRSLKGFQVLLEKEWLSFGHRFASRV-------GHGDGNHANSERSPLFVQFIDCVWQMTRQFPSAFEFNELFLITVLDHLFSCLFGTFLYNSEQERVSKEVYNKTVSLWSYVNSQIEEFTNPLYVNYE---HHVLYPIASLRHLELWVSYYVRWNPRMRPQVPI 604          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEK-------GDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAE-KINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPI 1778
            GE I     +V      T    G L +T+Y+L F S   ++     F            LD+NL  G I   E         + + + I CKD RS     K +  S     + L KY  P S  + LFAF  +     E G++      EY+R  + + +W ISK+N N+EVC+TYP  +  P  + ++ I     FR K+R PVL WIHP+T+AT+ R SQP  G T +R + DE YL++I DANA ++ L I DAR    A  +  + GG E++N Y ++  +FL IPNIHVMRES+RKL ++ YP  +   WH A++ T WL YIR +L G++ +A+   +S+ SV+VHCSDGWDRTAQ+TSL  LMLD Y+RT+RGFQ L++KEW+  GHK + R G   E   +       SER+P+F+QFIDCVWQ+ +QF +AFEFNE FLI ++D +YS LFG FL+NSEQ+R   EV  KT+S W ++NS  E + NP +   D   H VL+P   L  +  W  YY+R   + R Q P+
Sbjct:  120 GETIKTTVKDVMYICPFTGAVTGTLTITDYKLYFVSLERDA----PFI-----------LDVNL--GAISRLETISVQSLGENTSGMEIVCKDMRSPRFAYKKEEQSKLEILETLTKYAFPLSNELSLFAF-QYKEQFPEDGWKVYDPVAEYKRMGLPNESWSISKINSNYEVCDTYPALLVTPTSIKEDEIRRVASFRVKHRIPVLSWIHPETQATIVRCSQPMVGPTDRRCKEDEHYLQTIMDANAQSHKLAIFDARQNTVAHNHKTKDGGYENENFYPNMELNFLEIPNIHVMRESLRKLKEVVYPTIEEQRWHSAIDATHWLEYIRLLLAGAVRIADKVESSKSSVVVHCSDGWDRTAQLTSLSMLMLDSYYRTLRGFQVLLEKEWISFGHKFAARIGHGDENHAN-------SERSPLFVQFIDCVWQMMRQFPSAFEFNELFLITILDYLYSCLFGTFLYNSEQERVEKEVNRKTVSLWSYINSQSEDFTNPFY--VDYENH-VLYPLASLRHLELWVGYYVRWNPRMRPQMPV 631          

Query:  162 EVYDFKCGENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDG--------NCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQL 1832
            E++ + C   +     +VT     +    G   +TNYRL F                  S++  + L L+ P+G I   EK  G        N + I CKD R++    K D  +     + L K+  P +  + LFAF  +  +  E G++      EY+RQ I + +WRI++VN  +E+C+TYP  + VP ++SD+ +     FR ++R PVL WIHP+++A +TR SQP  G+  KR++ DE+YL+SI DANA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES RKL ++ YP    +NW   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRT Q+TSL  +MLD Y+RTIRGF+ L++KEW+  GH+  QRT       G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL N E Q+    V  +++S W  +NS +E + NPL+   + S H VL+P      +  W  YY+R   ++R    I    ++L  ++   Q +L
Sbjct:   17 EIFAYTC--ILYLSAKDVTYICPFSGAYRGSFTVTNYRLYF-----------------RSLERDRHLVLDAPLGIISRIEKIGGAASRGENPNGIEIVCKDMRNIRFAYKQDLRTRKSVFENLVKFAFPLNYGLPLFAF-EYKEVFPENGWKVYDPIQEYRRQGIPNESWRITRVNERYELCDTYPACLVVPANISDDELRKIAAFRAQDRIPVLSWIHPESQAAITRCSQPLPGVNGKRSKEDEKYLQSIMDANAQSHKVFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESQRKLKEISYPSIQEANWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTPQLTSLAMIMLDGYYRTIRGFEVLVEKEWVSFGHRFYQRT-------GHGDKNHADADRSPMFLQFIDCVWQMTRQFPNAFEFNEHFLIIILDHLYSCLFGTFLCNCELQKLKEGVLEESVSLWSFINSQLEDFINPLYV--NYSSH-VLYPVTSTRNLELWAGYYIRWNPRTRPPGAINSRYKVLLAKRAELQKRL 552          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDG--------NCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQL 1832
            G   +TNYRL F                  S++  + L L+ P+G I   EK  G        N + I CKD R++    K D  +     + L K+  P +  + LFAF  +  +  E G++      EY+RQ I + +WRI++VN  +E+C+TYP  + VP ++SD+ +     FR ++R PVL WIHP+++A +TR SQP  G+  KR++ DE+YL+SI DANA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES RKL ++ YP    +NW   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRT Q+TSL  +MLD Y+RTIRGF+ L++KEW+  GH+  QRT       G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL N E Q+    V  +++S W  +NS +E + NPL+   + S H VL+P      +  W  YY+R   ++R    I    ++L  ++   Q +L
Sbjct:   29 GSFTVTNYRLYF-----------------RSLERDRHLVLDAPLGIISRIEKIGGAASRGENPNGIEIVCKDMRNIRFAYKQDLRTRKSVFENLVKFAFPLNYGLPLFAF-EYKEVFPENGWKVYDPIQEYRRQGIPNESWRITRVNERYELCDTYPACLVVPANISDDELRKIAAFRAQDRIPVLSWIHPESQAAITRCSQPLPGVNGKRSKEDEKYLQSIMDANAQSHKVFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESQRKLKEISYPSIQEANWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTPQLTSLAMIMLDGYYRTIRGFEVLVEKEWVSFGHRFYQRT-------GHGDKNHADADRSPMFLQFIDCVWQMTRQFPNAFEFNEHFLIIILDHLYSCLFGTFLCNCELQKLKEGVLEESVSLWSFINSQLEDFINPLYV--NYSSH-VLYPVTSTRNLELWAGYYIRWNPRTRPPGAINSRYKVLLAKRAELQKRL 537          

Query:  270 YRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEK-------GDGNCLTIKCKDFRSVTLKLKNDS-NSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPI 1778
            Y   FW   S +   + F     +++      L++P+G I   EK            + I CKD R++ L  K +  N ++ F+ L++    P S  + LFAF + +      G++    + EY+RQ + + +W+I+K+N+ +E+C+TYP    VP  V DE       FR K R PVL WIHP+++AT+TR SQP  G   KR + DE+YL++I DANA ++ L I DAR    A  N  +GGG ES++ Y +    FL I NIHVMRES+RKL ++ YP  D + W   ++ T WL YIR +L GS+ +A+++ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTI+GF+ L++KEW+  GH+ + R        G        ++R+PIFLQFIDCVWQ+T QF AAFEFNE FLI ++D +YS LFG FL+NSEQQR   E+ TKTLS W ++NS ++++ NP +   +   H VL+P   L  +  W +YY+R   ++R Q PI
Sbjct:   43 YICPFWGAVSGTLTVTDFKMYFKNVERDPPFILDVPLGVISRVEKIGVQSQGSHSYGIEIVCKDMRNLRLAYKQEEQNKLEIFENLIKNAF-PVSNKLPLFAFSYKEKFSVN-GWKVYDPTAEYKRQGLPNESWKITKINNTYELCDTYPAVFVVPTSVLDEDFARVVAFRAKGRIPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNKTKGGGYESESAYPNAELIFLEIHNIHVMRESLRKLKEIVYPAIDEARWLSNVDGTHWLEYIRMLLAGSVRIADRVESSKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFEVLLEKEWISFGHRFAMRV-------GHGDDNHADADRSPIFLQFIDCVWQMTNQFPAAFEFNELFLITILDHLYSCLFGTFLYNSEQQRMKEEIQTKTLSLWSYINSHVDEFTNPFYVNYE---HHVLYPVASLSHLELWVNYYVRWNPRTRPQMPI 542          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDG--------NCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQL 1832
            G   +TNYRL F                  S++  + L L+ P+G I   EK  G        N + I CKD R++    K D  +     + L K+  P +  + LFAF  +  +  E G++      EY+RQ I + +WRI++VN  +E+C+TYP  + VP ++SD+ +     FR ++R PVL WIHP+++A +TR SQP  G+  KR++ DE+YL+SI DANA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES RKL ++ YP    +NW   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRT Q+TSL  +MLD Y+RTIRGF+ L++KEW+  GH+  QRT       G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL N E Q+    V  +++S W  +NS +E + NPL+   + S H VL+P      +  W  YY+R   ++R    I    ++L  ++   Q +L
Sbjct:   57 GSFTVTNYRLYF-----------------RSLERDRHLVLDAPLGIISRIEKIGGAASRGENPNGIEIVCKDMRNIRFAYKQDLRTRKSVFENLVKFAFPLNYGLPLFAF-EYKEVFPENGWKVYDPIQEYRRQGIPNESWRITRVNERYELCDTYPACLVVPANISDDELRKIAAFRAQDRIPVLSWIHPESQAAITRCSQPLPGVNGKRSKEDEKYLQSIMDANAQSHKVFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESQRKLKEISYPSIQEANWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTPQLTSLAMIMLDGYYRTIRGFEVLVEKEWVSFGHRFYQRT-------GHGDKNHADADRSPMFLQFIDCVWQMTRQFPNAFEFNEHFLIIILDHLYSCLFGTFLCNCELQKLKEGVLEESVSLWSFINSQLEDFINPLYV--NYSSH-VLYPVTSTRNLELWAGYYIRWNPRTRPPGAINSRYKVLLAKRAELQKRL 565          

Query:  270 YRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEK-------GDGNCLTIKCKDFRSVTLKLKNDS-NSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPI 1778
            Y   FW   S +   + F     +++      L++P+G I   EK            + I CKD R++ L  K +  N ++ F+ L++    P S  + LFAF + +      G++    + EY+RQ + + +W+I+K+N+ +E+C+TYP    VP  V DE       FR K R PVL WIHP+++AT+TR SQP  G   KR + DE+YL++I DANA ++ L I DAR    A  N  +GGG ES++ Y +    FL I NIHVMRES+RKL ++ YP  D + W   ++ T WL YIR +L GS+ +A+++ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTI+GF+ L++KEW+  GH+ + R        G        ++R+PIFLQFIDCVWQ+T QF AAFEFNE FLI ++D +YS LFG FL+NSEQQR   E+ TKTLS W ++NS ++++ NP +   +   H VL+P   L  +  W +YY+R   ++R Q PI
Sbjct:   70 YICPFWGAVSGTLTVTDFKMYFKNVERDPPFILDVPLGVISRVEKIGVQSQGSHSYGIEIVCKDMRNLRLAYKQEEQNKLEIFENLIKNAF-PVSNKLPLFAFSYKEKFSVN-GWKVYDPTAEYKRQGLPNESWKITKINNTYELCDTYPAVFVVPTSVLDEDFARVVAFRAKGRIPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNKTKGGGYESESAYPNAELIFLEIHNIHVMRESLRKLKEIVYPAIDEARWLSNVDGTHWLEYIRMLLAGSVRIADRVESSKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFEVLLEKEWISFGHRFAMRV-------GHGDDNHADADRSPIFLQFIDCVWQMTNQFPAAFEFNELFLITILDHLYSCLFGTFLYNSEQQRMKEEIQTKTLSLWSYINSHVDEFTNPFYVNYE---HHVLYPVASLSHLELWVNYYVRWNPRTRPQMPI 569          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPI-ADYSRILSRRKRI 1817
            GENI     +VT     T    G L +T+YRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S  + LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  KT+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:    9 GENIKDMAKDVTYICPFTGAVRGTLTVTSYRLYF-----------------KSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNGLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPTIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHSRYKELLAKRAEL 535          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPI-ADYSRILSRRKRI 1817
            GENI     +VT     T    G L +T+YRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S  + LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  KT+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:   81 GENIKDMAKDVTYICPFTGAVRGTLTVTSYRLYF-----------------KSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNGLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPTIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHSRYKELLAKRAEL 607          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDP 1775
            GE ++ E+  + +  F+   + G + +TNYRL   S  ++S                 +L L++P+G I   EK  G          L I CKD R++   LK + +S     ++L K+  P + N+ LFAFV+ +  + + G+      +EY+RQ + +++WRIS +N  +E+CETYP  + VP   SD+ +     FR++NR PVL WIHP+ K  + R SQP  G++ KRN+ DE+YL  I++ N   + L I DARP +NA AN A GGG ES + Y +    FL+I NIHVMRES++K+ D+ YP  + S+W  +LE T WL +I+ +L G++ VA++++S + SVLVHCSDGWDRTAQ+TSL  LMLD ++RTI GF+ L+ KEW+  GHK + R        G        ++R+PIFLQFIDCVWQ+++QF  AFEFNE FLI ++D +YS  FG FLFN +  R   ++  +T+S W  +NS+ +K++NP +T   +  +RVL+P   +  +  W +YY+R   + + Q P
Sbjct:   40 GELLITEKEVIYICPFNGPIK-GRVYITNYRLYLRSLETDS-----------------ALILDVPLGVISRIEKMGGATSRGENSYGLDITCKDLRNLRFALKQEGHSRRDMFEILVKHAFPLAHNLPLFAFVNEEKFNVD-GWTVYNPVEEYRRQGLPNHHWRISFINKCYELCETYPALLVVPYRTSDDDLRRIATFRSRNRLPVLSWIHPENKMVIMRCSQPLVGMSGKRNKDDEKYLDVIRETNKQTSKLMIYDARPSVNAVANKATGGGYESDDAYQNSELSFLDIHNIHVMRESLKKVKDIVYPNIEESHWLSSLESTHWLEHIKLVLTGAIQVADQVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRTIEGFEILVQKEWISFGHKFASR-------IGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNEGFLITVLDHLYSCRFGTFLFNCDSARERQKLTERTVSLWSLINSNKDKFKNPFYT---KEINRVLYPVASMRHLELWVNYYIRWNPRVKQQQP 550          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDP 1775
            GE ++ E+  + +  F+   + G + +TNYRL   S  ++S                 +L L++P+G I   EK  G          L I CKD R++   LK + +S     ++L K+  P + N+ LFAFV+ +  + + G+      +EY+RQ + +++WRIS +N  +E+CETYP  + VP   SD+ +     FR++NR PVL WIHP+ K  + R SQP  G++ KRN+ DE+YL  I++ N   + L I DARP +NA AN A GGG ES + Y +    FL+I NIHVMRES++K+ D+ YP  + S+W  +LE T WL +I+ +L G++ VA++++S + SVLVHCSDGWDRTAQ+TSL  LMLD ++RTI GF+ L+ KEW+  GHK + R        G        ++R+PIFLQFIDCVWQ+++QF  AFEFNE FLI ++D +YS  FG FLFN +  R   ++  +T+S W  +NS+ +K++NP +T   +  +RVL+P   +  +  W +YY+R   + + Q P
Sbjct:   40 GELLITEKEVIYICPFNGPIK-GRVYITNYRLYLRSLETDS-----------------ALILDVPLGVISRIEKMGGATSRGENSYGLDITCKDLRNLRFALKQEGHSRRDMFEILVKHAFPLAHNLPLFAFVNEEKFNVD-GWTVYNPVEEYRRQGLPNHHWRISFINKCYELCETYPALLVVPYRTSDDDLRRIATFRSRNRLPVLSWIHPENKMVIMRCSQPLVGMSGKRNKDDEKYLDVIRETNKQTSKLMIYDARPSVNAVANKATGGGYESDDAYQNSELSFLDIHNIHVMRESLKKVKDIVYPNIEESHWLSSLESTHWLEHIKLVLTGAIQVADQVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRTIEGFEILVQKEWISFGHKFASR-------IGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNEGFLITVLDHLYSCRFGTFLFNCDSARERQKLTERTVSLWSLINSNKDKFKNPFYT---KEINRVLYPVASMRHLELWVNYYIRWNPRVKQQQP 550          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDP 1775
            GE ++ E+  + +  F+   + G + +TNYRL   S  ++S                 +L L++P+G I   EK  G          L I CKD R++   LK + +S     ++L K+  P + N+ LFAFV+ +  + + G+      +EY+RQ + +++WRIS +N  +E+CETYP  + VP   SD+ +     FR++NR PVL WIHP+ K  + R SQP  G++ KRN+ DE+YL  I++ N   + L I DARP +NA AN A GGG ES + Y +    FL+I NIHVMRES++K+ D+ YP  + S+W  +LE T WL +I+ +L G++ VA++++S + SVLVHCSDGWDRTAQ+TSL  LMLD ++RTI GF+ L+ KEW+  GHK + R        G        ++R+PIFLQFIDCVWQ+++QF  AFEFNE FLI ++D +YS  FG FLFN +  R   ++  +T+S W  +NS+ +K++NP +T   +  +RVL+P   +  +  W +YY+R   + + Q P
Sbjct:   40 GELLITEKEVIYICPFNGPIK-GRVYITNYRLYLRSLETDS-----------------ALILDVPLGVISRIEKMGGATSRGENSYGLDITCKDLRNLRFALKQEGHSRRDMFEILVKHAFPLAHNLPLFAFVNEEKFNVD-GWTVYNPVEEYRRQGLPNHHWRISFINKCYELCETYPALLVVPYRTSDDDLRRIATFRSRNRLPVLSWIHPENKMVIMRCSQPLVGMSGKRNKDDEKYLDVIRETNKQTSKLMIYDARPSVNAVANKATGGGYESDDAYQNSELSFLDIHNIHVMRESLKKVKDIVYPNIEESHWLSSLESTHWLEHIKLVLTGAIQVADQVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRTIEGFEILVQKEWISFGHKFASR-------IGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNEGFLITVLDHLYSCRFGTFLFNCDSARERQKLTERTVSLWSLINSNKDKFKNPFYT---KEINRVLYPVASMRHLELWVNYYIRWNPRVKQQQP 550          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRIFQTQLNRQPE-SDEETNIAQPAGEARQ 1895
            GENI     +VT     T    G L +TNYRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S N+ LFAF  +  +  E G++      EY+RQ I + +WRI+KVN  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+++ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  +T+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  + +     Q E S+  T+ ++ AG   Q
Sbjct:   81 GENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF-----------------KSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLSLFAF-EYKEVFPENGWKLYDSLSEYRRQGIPNESWRITKVNERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADRVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPRRTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYVRWNPRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRSTSSSERAGSPAQ 634          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRIFQTQLNRQPE-SDEETNIAQPAGEARQ 1895
            GE I     +VT     T    G L +TNYRL F                  S++      L+  +G I   EK  G          L I CKD R++    K +  +     + L KY  P S N+ LFAF  +  +  E G++      EY+RQ I + +WR+SK+N ++E+C+TYP  +AVP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL +SEQQR    +  KT+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+P+ + Y  +L++R  + +     Q E ++  T+ ++ AG   Q
Sbjct:    9 GETIKDMAKDVTYICPFTGAIRGTLTVTNYRLYF-----------------KSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLEIVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAF-EYKEVFPENGWKVYDPIWEYRRQGIPNESWRLSKINEHYELCDTYPAILAVPVNIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLSLLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCSSEQQRVKESLPKKTVSLWSYINSQLEDFTNPLYV--SYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPVHNRYKELLAKRAELQKKVEELQREITNRSTSSSERAGSPAQ 562          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            GENI     +VT     T    G L +TNYRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S N+ LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  +T+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:   81 GENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF-----------------KSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAEL 607          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            GENI     +VT     T    G L +TNYRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S N+ LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RT RGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  +T+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:   81 GENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF-----------------KSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHEIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVIVHCSDGWDRTAQLTSLAMLMLDGYYRTTRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAEL 607          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPI-ADYSRILSRRKRI 1817
            GENI     +VT     T    G L +T+YRL F                  S++      L+  +G I   EK  G          L   CKD R++    K +  +     + L KY  P S  + LFAF  +  +  E G++      EY+RQ I + +WRI+K+N  +E+C+TYP  + VP ++ DE +     FR++ R PVL WIHP+++AT+TR SQP  G++ KR++ DE+YL++I D+NA ++ + I DARP +NA AN A+GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + ++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RTIRGF+ L++KEWL  GH+   R        G        ++R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS LFG FL NSEQQR    +  KT+S W ++NS +E + NPL+     S H VL+P   +  +  W  YY+R   + + Q+PI + Y  +L++R  +
Sbjct:   81 GENIKDMAKDVTYICPFTGAVRGTLTVTSYRLYF-----------------KSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNGLPLFAF-EYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPTIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV-------GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLY--GSYSNH-VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHSRYKELLAKRAEL 607          

Query:  246 NGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIK-EFKSLDLNLPVGFIQEFEK---GDGNC----LTIKCKDFRSVTLKL------------KNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLS----------DEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKI-NSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEF--------------GSTSSTSQKS---ERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRIL-SRRKRIFQTQLNRQPESDEETNIAQPAGEA 1889
             G+L LTNY+ +F+ YN  +   S ++ +P+      +   L +P+G IQ  ++   G G C    L I CKD R + L L            + DS     F   +  Y  P      LFA+V       E  + N V S          DEY RQ I +N W+I+K+N ++ + +TYP  +AVP DVSDE +      R++ R PVL W+HP++KA+LTR+SQP  G+  +R+ +DE  ++ I+ ANA  N L I DARP +NA AN +RGGG+E+   Y ++ Y FLNI NIH MR ++  + ++C+P+P  S+W K L ++KWL +I+QI+  +  VA+KI N + SVLVHCSDGWDRTAQ+TSL  LMLDP++RT+RGF+ L++KEW   GHK +QRTGG T+                G  SS  + S   ER+P+FLQFIDCVWQ+TQQF  +FEFNE+FLI +MD +Y+  FG FLFN E Q R + V  +T+S W +V+SDI  Y+NPL+TPA+ SGHR++FPQ+ L  ++FW +YY+R +   R QDP+A   R L    KR  +     Q  +++    ++P+ EA
Sbjct:   38 TGILELTNYKFVFYQYNKQT-DASQYHTLPSFFGLHQRQFMLQVPLGVIQSIDQKHGGQGACRGLGLYIVCKDLRYIKLILTVCSDFHVHPFWEQDSGRSSGFYDKMRAYTFPSISKQPLFAYVF-----GEHCFANKVFSFNGWEVYRPEDEYHRQNIFTNGWKITKINMDYRLSDTYPAVLAVPWDVSDELLMACAPHRSRGRVPVLSWLHPESKASLTRASQPQVGVQGRRSAADEELVQQIRTANANANSLLIFDARPQMNAMANKSRGGGVENPTYYENVQYMFLNIQNIHAMRAALTNVFEVCFPQPKESDWFKFLADSKWLYHIKQIIFAATSVADKIENHKTSVLVHCSDGWDRTAQVTSLAMLMLDPFYRTLRGFEVLVEKEWCSFGHKFAQRTGGPTDGGVVLPLTGSTIAPLPGKNSSPGRPSNSEERSPVFLQFIDCVWQMTQQFPHSFEFNERFLITIMDELYAAKFGTFLFNCEMQARDHGVRERTVSLWSYVDSDIHSYQNPLYTPAEVSGHRIIFPQHSLAQLQFWSAYYVRWHPIMRLQDPVARRDRALVDVMKRFRELTTAAQRNTNDLPVSSKPSTEA 628          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIK-EFKSLDLNLPVGFIQEFEK-------GDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEP-----GYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKI-NSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEF---------------GSTSS--TSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPESDEETNIAQPAG 1883
            G + LTNYR +F S+       S+++ +P  +    K   L +P+G IQ  E+         G  L I CKD R+V L L + + +   ++KL + Y  P      LFA+   +    E      G+      +EY RQ I +N W+++K+N ++ + +TYP  +AVP +V+DE +      R++ R PVL W+HP++KA+LTR+SQP  G+  +R+ +DE  ++ I+ ANA  N L I DARP +NA AN  RGGG+E+   Y ++ Y FLNI NIH MR S+  + + CYP P   NW KAL ++KWL +I+QI+  +  VA+KI N + SVLVHCSDGWDRTAQ+TSL  LMLDP++RT+RGF+ LI+KEW   GHK +QRTGG  +                 GS+ S   S   ER+P+FLQFIDCVWQ+TQQF  +FEFNE+FLI +MD VY+  FG FLFN E Q R + V  +T+S W ++NSD++ Y+NP++TPA+ SGHR++FPQ+ L  ++FW  YY+R +   RSQDP+    R L    + F+ +L    +     +IA+PA 
Sbjct:   39 GNVELTNYRFIF-SHQLKHGDASYYHTLPAFVGLTHKLFVLQVPLGVIQSIEQKHTVQAASKGIGLYIVCKDLRNVKLLLTDFARATTFYEKL-KAYAFPSISKQPLFAYTFGERCIAENVFPFNGWEVYTPEEEYHRQNIFTNGWKLTKINVDYRLSDTYPALLAVPWEVTDELLMACAPHRSRGRVPVLSWLHPESKASLTRASQPQVGMQGRRSAADEELVRLIRTANANANNLLIFDARPQMNAVANKGRGGGVENPTYYENVQYVFLNIQNIHAMRASLTNVYEACYPMPKEGNWFKALADSKWLYHIKQIIFAATSVADKIENHKSSVLVHCSDGWDRTAQVTSLAMLMLDPFYRTLRGFEVLIEKEWCSFGHKFAQRTGGPADGGVVMPSNAGMPPLPPNGSSISPKPSSADERSPVFLQFIDCVWQMTQQFPHSFEFNERFLITIMDEVYAARFGTFLFNCEMQARDHGVRERTVSLWSYMNSDLKSYQNPMYTPAEVSGHRIIFPQHSLVHLQFWSGYYVRWHPIMRSQDPVLRRDRALVDVMKRFR-ELTIAAQRTAAGDIAEPAA 611          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIK-EFKSLDLNLPVGFIQEFEK-------GDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEP-----GYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKI-NSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEF---------------GSTSS--TSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPESDEETNIAQPAG 1883
            G + LTNYR +F S+       S ++ +P  +    K   L +P+G IQ  E+         G  L + CKD R+V L L + + +   ++KL + Y  P      LFA+   +    E      G+      +EY RQ I +N W+++K+N ++ + +TYP  +AVP +V+DE +      R++ R PVL W+HP++KA+LTR+SQP  G+  +R+ +DE  ++ I+ ANA  N L I DARP +NA AN  RGGG+E+   Y ++ Y FLNI NIH MR S+  + + CYP P   NW KAL ++KWL +I+QI+  +  VA+KI N + SVLVHCSDGWDRTAQ+T+L  LMLDP++RT+RGF+ LI+KEW   GHK +QRTGG  +                 GS+ S   S   ER+P+FLQFIDCVWQ+TQQF  +FEFNE+FLI +MD VY+  FG FLFN E Q R + V  +T+S W ++NSD++ Y+NP++TPA+ SGHR++FPQ+ L  ++FW  YY+R +   RSQDP+    R L    + F+ +L    +     +IA+PA 
Sbjct:   39 GSVELTNYRFIF-SHQLKHGDTSCYHTLPAFVGLTHKLFVLQVPLGIIQSIEQKHTVQAAAKGIGLYVVCKDLRNVKLLLTDLARATTFYEKL-KAYTFPSISKQPLFAYTFGERCIAENVFPFNGWEVYTPEEEYHRQNIFTNGWKLTKINVDYRLSDTYPALLAVPWEVTDELLMACAPHRSRGRVPVLSWLHPESKASLTRASQPQVGMQGRRSAADEELVRLIRTANANANNLLIFDARPQMNAVANKGRGGGVENPTYYENVQYVFLNIQNIHAMRASLTNVYEACYPMPKEGNWFKALADSKWLYHIKQIIFAATSVADKIENHKSSVLVHCSDGWDRTAQVTALAMLMLDPFYRTLRGFEVLIEKEWCSFGHKFAQRTGGPADGGVVMPPNTGMPPLPPNGSSVSPKPSSADERSPVFLQFIDCVWQMTQQFPHSFEFNERFLITIMDEVYAARFGTFLFNCEMQARDHGVRERTVSLWSYMNSDLKSYQNPMYTPAEVSGHRIIFPQHSLVHLQFWSGYYVRWHPIMRSQDPVLRRDRALVDVMKRFR-ELTIAAQRTAAGDIAEPAA 611          

Query:  246 NGLLMLTNYRLLFW-SYNSNSFGKSHFYE--IPNSIKEFKSLDLNLPVGFIQEFE--------KGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEP-----GYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKI-NSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEF----------------GSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRIL 1799
            +GLL LTNY+LLF  +       + H Y   I  + ++F    L +P+G IQ  E        +  G  L I CKD R + L L +++ +   +D+L   Y  P      LFA+V  +    E      G+      DEY RQ I +N W+++KVN ++ + +TYP  +AVP +VSDE +T     R++ R PVL W+HP++KA+LTR+SQP  G+  +R+ +DE  ++ I+ ANA  N L I DARP  NA AN  RGGG+E+   Y ++ Y FLNI NIH MR ++ K+ + C+P+P++  W KAL ++KWL +I+QI+  +  VA+KI N + SVLVHCSDGWDRTAQ+TSL  LMLDP++RT+RGF+ LI+KEW   GHK +QRTGG  +                  G T   S   ER+P+FLQFIDCVWQ+ QQF  +FEFNE+FLI +MD +Y+  +G FLFNSE Q R + V  +T+S W H+  D + Y NPL+TPA+ SGHRV+FPQ+ L  ++FW +YY+R +   R Q+P+A   R L
Sbjct:   37 SGLLELTNYKLLFCQTLKPQDANQYHTYPSFITYAQRQFV---LQIPLGVIQTIEQKHAQTGSRTGGLGLYIMCKDLRDIKLMLTDNARASLFYDQL-RAYAFPSISRQPLFAYVFGEKCLAEKVYHFNGWDVYDPEDEYHRQNIFTNGWKVTKVNADYRLSDTYPALLAVPWEVSDELLTACAPHRSRGRVPVLSWLHPESKASLTRASQPQVGVQGRRSAADEELVRQIRAANANANSLLIFDARPHANAVANKGRGGGVENPTYYENVQYMFLNIQNIHAMRAALTKIFEACFPRPEDGRWLKALADSKWLYHIKQIIFAATSVADKIENHKTSVLVHCSDGWDRTAQVTSLAMLMLDPFYRTLRGFEVLIEKEWCSFGHKFAQRTGGPADGGVVLPSGPNSSGPVASNGGTGRPSSPDERSPVFLQFIDCVWQMMQQFPHSFEFNERFLITIMDELYAARYGTFLFNSEMQARDHGVRERTISLWSHIAYDYKGYINPLYTPAEVSGHRVIFPQHSLAQLQFWTAYYIRWHPIMRLQEPVARRDRAL 583          

Query:  246 NGLLMLTNYRLLFW-SYNSNSFGKSHFYE--IPNSIKEFKSLDLNLPVGFIQEFE--------KGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEP-----GYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKI-NSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEF----------------GSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRIL 1799
            +GLL LTNY+LLF  +       + H Y   I  + ++F    L +P+G IQ  E        +  G  L I CKD R + L L +++ +   +D+L   Y  P      LFA+V  +    E      G+      DEY RQ I +N W+++KVN ++ + +TYP  +AVP +VSDE +T     R++ R PVL W+HP++KA+LTR+SQP  G+  +R+ +DE  ++ I+ ANA  N L I DARP  NA AN  RGGG+E+   Y ++ Y FLNI NIH MR ++ K+ + C+P+P++  W KAL ++KWL +I+QI+  +  VA+KI N + SVLVHCSDGWDRTAQ+TSL  LMLDP++RT+RGF+ LI+KEW   GHK +QRTGG  +                  G T   S   ER+P+FLQFIDCVWQ+ QQF  +FEFNE+FLI +MD +Y+  +G FLFNSE Q R + V  +T+S W H+  D + Y NPL+TPA+ SGHRV+FPQ+ L  ++FW +YY+R +   R Q+P+A   R L
Sbjct:   37 SGLLELTNYKLLFCQTLKPQDANQYHTYPSFITYAQRQFV---LQIPLGVIQTIEQKHAQTGSRTGGLGLYIMCKDLRDIKLMLTDNARASLFYDQL-RAYAFPSISRQPLFAYVFGEKCLAEKVYHFNGWDVYDPEDEYHRQNIFTNGWKVTKVNADYRLSDTYPALLAVPWEVSDELLTACAPHRSRGRVPVLSWLHPESKASLTRASQPQVGVQGRRSAADEELVRQIRAANANANSLLIFDARPHANAVANKGRGGGVENPTYYENVQYMFLNIQNIHAMRAALTKIFEACFPRPEDGRWLKALADSKWLYHIKQIIFAATSVADKIENHKTSVLVHCSDGWDRTAQVTSLAMLMLDPFYRTLRGFEVLIEKEWCSFGHKFAQRTGGPADGGVVLPGGPNSSGPVASNGGTGRPSSPDERSPVFLQFIDCVWQMMQQFPHSFEFNERFLITIMDELYAARYGTFLFNSEMQARDHGVRERTISLWSHIAYDYKGYINPLYTPAEVSGHRVIFPQHSLAQLQFWTAYYIRWHPIMRLQEPVARRDRAL 583          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC------LTIKCKDFRSVTLKLKNDSNSVDR-FDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFT--PADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRR----KRIFQTQ---LNRQPESDEETN 1865
            G L +TNYRLLF   N            P  +       L+LP+G I   +K  G          + CKD R++    K   +S+ +   ++L K+  P S N+ LFAF  ++ +  E G++      EY+RQ + + +WRISKVN ++E+C++YP  + VP  ++D+ +     FR K R PVL W+HP+++A + R SQP +G++ KR + DE+ L++I DANA ++ + I DARP +NA AN  +GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + S+W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  +MLD ++RT+ GFQ LI+KEW+  GH+  QR G      G  + T   ++R+PIFLQFIDCVWQ+TQQF AAFEFNE FLI L+D +YS LFG FL NSEQQR   E+  +T+S W  VNS +E++ NPL+   PA      VL P   +  ++ W SYY+R   + R Q+P+   Y  +L++R    KR+ + Q    NR   S E   
Sbjct:   98 GTLTVTNYRLLFRGINRE----------PGVV-------LDLPLGVISRVDKIGGASSRGDVSYHLFCKDMRNLRFVHKQPDDSLKKSVFEVLTKFAFPVSNNLSLFAF-EYNQVFPENGWKVYDPLAEYRRQGLPNESWRISKVNDHYELCDSYPAALVVPVTITDDELRRVAAFRAKGRIPVLSWLHPESQAAVVRCSQPMSGVSGKRCKEDEKLLQAIMDANAQSHKIFIFDARPSVNAAANKMKGGGCESEDAYQNAELVFLDIHNIHVMRESLRKLKEVVYPNIEESHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLSLIMLDSHYRTVTGFQKLIEKEWISFGHRFQQRVG-----HGDQNHTD--ADRSPIFLQFIDCVWQMTQQFPAAFEFNEYFLITLLDQLYSCLFGTFLCNSEQQRVKEELVKRTVSVWSLVNSQLEEFVNPLYVHYPA-----HVLLPSVSIRHLQLWVSYYIRWNPRMRPQEPVHQRYKELLAKRAELQKRVEELQREVANRASTSSERAG 624          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC------LTIKCKDFRSVTLKLKNDSNSVDR-FDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFT--PADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRIFQ--TQLNRQPESDEETNIAQPAGEARQI 1898
            G L +TNYRLLF   N            P  +       L+LP+G I   +K  G          + CKD R++    K   +S+ +   ++L K+  P S N+ LFAF  ++ +  E G++      EY+RQ + + +WRISKVN ++E+C++YP  + VP  ++D+ +     FR K R PVL W+HP+++A + R SQP +G++ KR + DE+ L++I DANA ++ + I DARP +NA AN  +GGG ES++ Y +    FL+I NIHVMRES+RKL ++ YP  + S+W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRTAQ+TSL  +MLD ++RT+ GFQ LI+KEW+  GH+  QR G      G  + T   ++R+PIFLQFIDCVWQ+TQQF AAFEFNE FLI L+D +YS LFG FL NSEQQR   E+  +T+S W  VNS +E++ NPL+   PA      VL P   +  ++ W SYY+R   + R Q+P+   Y  +L++R  + +   +L R+  +   T+  +     R I
Sbjct:  123 GTLTVTNYRLLFRGINRE----------PGVV-------LDLPLGVISRVDKIGGASSRGDVSYHLFCKDMRNLRFVHKQPDDSLKKSVFEVLTKFAFPVSNNLSLFAF-EYNQVFPENGWKVYDPLAEYRRQGLPNESWRISKVNDHYELCDSYPAALVVPVTITDDELRRVAAFRAKGRIPVLSWLHPESQAAVVRCSQPMSGVSGKRCKEDEKLLQAIMDANAQSHKIFIFDARPSVNAAANKMKGGGCESEDAYQNAELVFLDIHNIHVMRESLRKLKEVVYPNIEESHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLSLIMLDSHYRTVTGFQKLIEKEWISFGHRFQQRVG-----HGDQNHTD--ADRSPIFLQFIDCVWQMTQQFPAAFEFNEYFLITLLDQLYSCLFGTFLCNSEQQRVKEELVKRTVSVWSLVNSQLEEFVNPLYVHYPA-----HVLLPSVSIRHLQLWVSYYIRWNPRMRPQEPVHQRYKELLAKRAELQKRVEELQREVANRASTSSERAGSPTRSI 655          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPE 1847
            GE I     +V      +   +G L +T+Y+L F      S  +   + +  ++     L+    +G     E   G  L I CKD R+     K    S     ++L KY  P S N+ LFAF  +     E G++      EY+RQ + + +W ISK+N ++EVCETYP  + +P  +S++ +     FR K RFPVL WIHP+++A + R  QP  G + +R   DERYL+++ DANA ++ L I DAR    A  N A+ GG E+++ Y ++  +FL IPNIHVMRES+RKL ++ YP  D   W  +++ T WL YIR +L G++ +A++I S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+R++RGFQ L++KEWL  GH+ + R        G        SER+P+F+QFIDCVWQ+T+QF +AFEFNE FLI ++D +YS LFG FL+NSEQ+R + EV++KT+S W ++NS +E + NPL+   +   H VL+P   L  +  W SYY+R   ++R Q P+  + + L     + + +L R+ E
Sbjct:   85 GEIIKAIAKDVMYICPFSGAVSGTLTITDYKLYF-----KSLARDPPFVLDVNLGAVSRLET---IGVQSHGENTRG--LEIVCKDLRNPRFAYKKQEQSKLEIFEMLSKYAFPLSHNMTLFAF-RYQEKFPEDGWKVYDPVAEYKRQGLPNESWLISKINSSYEVCETYPALLVLPASISEDELKRVAAFRAKRRFPVLSWIHPESQAAIVRCGQPQVGPSDRRCREDERYLQTVLDANAQSHKLCIYDARQSSVADTNKAKDGGYENESFYPNVELNFLEIPNIHVMRESLRKLKEVVYPAIDEQRWFSSVDATHWLEYIRLLLAGAVRIADRIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRSLRGFQVLLEKEWLSFGHRFASRV-------GHGDQNHANSERSPLFVQFIDCVWQMTRQFPSAFEFNELFLITMLDHLYSCLFGTFLYNSEQERVSKEVFSKTVSLWSYINSQVEDFSNPLYVNCE---HHVLYPVASLRNLELWVSYYVRWSPRTRPQVPVHHHMKEL----LLMRAELQRRVE 615          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPE 1847
            GE I     +V      +   +G L +T+Y+L F      S  +   + +  ++     L+    +G     E   G  L I CKD R+     K    S     ++L KY  P S N+ LFAF  +     E G++      EY+RQ + + +W ISK+N ++EVCETYP  + +P  +S++ +     FR K RFPVL WIHP+++A + R  QP  G + +R   DERYL+++ DANA ++ L I DAR    A  N A+ GG E+++ Y ++  +FL IPNIHVMRES+RKL ++ YP  D   W  +++ T WL YIR +L G++ +A++I S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+R++RGFQ L++KEWL  GH+ + R        G        SER+P+F+QFIDCVWQ+T+QF +AFEFNE FLI ++D +YS LFG FL+NSEQ+R + EV++KT+S W ++NS +E + NPL+   +   H VL+P   L  +  W SYY+R   ++R Q P+  + + L     + + +L R+ E
Sbjct:  108 GEIIKAIAKDVMYICPFSGAVSGTLTITDYKLYF-----KSLARDPPFVLDVNLGAVSRLET---IGVQSHGENTRG--LEIVCKDLRNPRFAYKKQEQSKLEIFEMLSKYAFPLSHNMTLFAF-RYQEKFPEDGWKVYDPVAEYKRQGLPNESWLISKINSSYEVCETYPALLVLPASISEDELKRVAAFRAKRRFPVLSWIHPESQAAIVRCGQPQVGPSDRRCREDERYLQTVLDANAQSHKLCIYDARQSSVADTNKAKDGGYENESFYPNVELNFLEIPNIHVMRESLRKLKEVVYPAIDEQRWFSSVDATHWLEYIRLLLAGAVRIADRIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRSLRGFQVLLEKEWLSFGHRFASRV-------GHGDQNHANSERSPLFVQFIDCVWQMTRQFPSAFEFNELFLITMLDHLYSCLFGTFLYNSEQERVSKEVFSKTVSLWSYINSQVEDFSNPLYVNCE---HHVLYPVASLRNLELWVSYYVRWSPRTRPQVPVHHHMKEL----LLMRAELQRRVE 638          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSV-DRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPI 1778
            GE  + +++ + +  F+     G + +TNYRL F S ++ S                 ++ L++P+G I   EK  G          L I CKD R++   LK + +S  D F ++  KY  P S    LFAF+  +   +E G+      DEY+RQ + +  WRIS +N N+E+C+TYP  + VP   ++E +     FR++ R PVL WIH D +A + R SQP  G++ KRN+ DERYL  I++AN    L TI DARP +NA AN A GGG E  + Y +    FL+I NIHVMRES++KL D+ YP  + S+W  +LE T WL +I+ +L G++ VA+K++S  SV+VHCSDGWDRTAQ+TSL  LMLD YFRT RGFQ L++KEW+  GHK + R G      G  +   Q  +R+PIFLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS  FG FL+N E  R    V  KT+S W  +NS    Y NP +T   ES H VL+P   +  +  W +YY+R   + R Q P+
Sbjct:   40 GEERIIDKDLIYMCPFN-GALKGKVFITNYRLYFRSTDTES-----------------TVTLDVPLGNISRIEKMGGASSRGENSYGLDITCKDMRNLRFALKQEGHSRRDLFGEIF-KYAFPLSHGQPLFAFLSQEKF-EENGWNVYKPMDEYRRQGLPNERWRISFINSNYELCDTYPTILVVPFKATEEDLRRVATFRSRCRIPVLSWIHRDNQAVIMRCSQPLVGMSGKRNKDDERYLDIIREANGTTKL-TIYDARPNVNAVANKATGGGYEGDDAYQNAELVFLDIHNIHVMRESLKKLKDIVYPNVEESHWLSSLESTHWLEHIKLVLSGAIQVADKVSSGNSVVVHCSDGWDRTAQLTSLSMLMLDSYFRTFRGFQVLLEKEWIGFGHKFASRIG-----HGDKNHADQ--DRSPIFLQFIDCVWQMTKQFPTAFEFNEHFLITVLDHLYSCRFGTFLYNCESVRENYNVRAKTVSLWSLINSSTSIYMNPFYTA--ESSH-VLYPVASMRHLELWVNYYIRWNPRIRHQLPL 549          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNN-LLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADY-SRILSRRKRI 1817
            GE++  EE  VT          G L++T+YRL F S      G      +P          L++P+G +   EK  G          L + CKD R++    + + +S  +    L K+  P S +++LFAF + +  H E G++      EYQR  +++  W+ISK+N ++E+C+TYP  + VP++ +D+ +     FR++ R PVL W+HP   A+LTR SQP  G++ KR+  DERYL+ I  ANA  +  L I DARP +NA AN A+GGG E++  Y    + FL+I NIHVMRES+RKL +L +P    S W  +LE T WL +I+ +L G++ +AEK+  +R SVLVHCSDGWDRTAQ+++L  L+LDPY+RT+RGF+ L++KEW+  GHK  QR        G        S+R+PIFLQF+DCVWQ+T+QF  AFEFNE+FLI L+D +YS L+G F+ N E+ RR      KT+S W  VNS  +++ +PL+   D    RVL P + +  ++ W SYY+R    ++  DP+ +  S +L++R+ +
Sbjct:   20 GESVKAEEPGVTYLCPYAGKLRGTLVITSYRLYFQSKEREEEG------LP--------FTLDVPLGVVNRIEKAGGASSRGEDAYRLEVTCKDLRNLRFAHRQEGHSRRKVFDTLVKFAFPLSHSMRLFAFDYKERFH-EDGWKIYDPEKEYQRLGMDNPPWKISKLNESYELCDTYPTVLVVPRNATDDDLRRTAAFRSRGRLPVLSWLHPRNLASLTRCSQPQVGVSGKRSREDERYLQLIMMANASQSRRLAIYDARPGVNAIANKAKGGGYETEEAYPFAEFVFLDIHNIHVMRESLRKLKELVFPTVTESRWLSSLEATHWLEHIKAVLSGAIQIAEKLELERTSVLVHCSDGWDRTAQLSALAMLLLDPYYRTLRGFEVLVEKEWVSSGHKFQQRV-------GHGDKNHADSDRSPIFLQFVDCVWQLTKQFPTAFEFNERFLIMLLDNLYSCLYGTFMGNCEKGRRQERTREKTVSLWSMVNSRQQEFISPLY---DREYTRVLTPVHSMRQLQLWVSYYIRWDPIAQLPDPVEELCSNLLAKREEL 550          

Query:  405 GDGNCLTIKCKDFRSVTLKL------KNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCY-PKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-----SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSD--IEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLR 1745
            G    LTIKCKD R + L +       N ++S++    L    +         F    F+A+  E G+ + +   E+ R    + +WR+S VN +F VC +YP  V +PK + DE +     FR   RFPVL + H      + R SQP TG   KR + DE+ + ++           IID R +  A+   A+GGG E +  Y        +I   ++M++S  KL + C  P  +   W   LE + WL +I+ IL  + + A+ ++S R     SVLVH SDG D T Q+++L Q++LD   RT+RGFQ L+++EWL  GH   +R         S  +  +  + AP FL F+DC  QI +QF  +FEF E+FL+ L +  Y+  FG FL NSE +R   +V  KT+S W  VN    +E+Y NPL+ P + +    ++P      +  W+  +LR
Sbjct:   64 GTVGTLTIKCKDLRIILLHIPGMEECHNIASSIEVLSTLTAVNLY-----YPFFYRPMFEAL--EDGWHSFLPEHEFTRLTSHTADWRLSHVNKDFTVCPSYPPVVIIPKAIDDEMVKKVSAFRQNGRFPVLSYYHKTNGMVMMRCSQPLTGSGGKRCKDDEKLVNAVLGPGKRG---YIIDTRSLHIAQQARAKGGGYEPEAHYPQWRRINKSIERYNLMQDSFIKLVEACNDPSHNMDRWLSKLEASNWLGHIKDILTAACLAAQCLDSARTREGASVLVHGSDGTDSTLQVSALAQVILDQDCRTLRGFQALVEREWLQAGHPFQERCS------RSAFANVKPRQEAPSFLLFLDCCQQIQRQFPCSFEFGERFLVLLFEHAYASQFGTFLCNSELERMKMKVQQKTVSMWSWVNRPEVMEQYLNPLYEPNNLA----IWPSVAPQSLVLWEGVFLR 504          

Query: 1203 SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLN 1835
            SVLVHCSDGWDRTAQ+ S+ +++LDPY+RT+RGF  LI+KEW+  GHK SQR G +              E +P+FLQ ++CVWQ++ QF  AFEF+E+ L  +    +S  FGNFL N E++R    V  KT S W  +    E++ NPL+         VL P     C RFW+  +      S S+  +A+    L ++ +  Q ++ 
Sbjct:    9 SVLVHCSDGWDRTAQVCSVAEILLDPYYRTLRGFLVLIEKEWISFGHKFSQRCGFV---------EGDAREVSPVFLQLLECVWQLSLQFPCAFEFSERLLTSVHAHTHSCQFGNFLGNCERERAQLRVKEKTYSLWAFLWDKREEFYNPLYRADHRQNRGVLKPNLAPQCFRFWRGMFDAQDGASYSRPQVAEAVSKLQKKTQRLQGEVT 210          

Query:  405 GDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVH---FDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAY--NNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKP-DNSNWHKALEETKWLNYIRQILLGSLMVA 1181
              G  L +  K FRS+ LK + + +  D     + K   P + +  LFAF +     A  +E G+    L  E++R  + + +W+++ +N N+EVC TYP ++ VP  +S + +  + +FR+K RFP L ++H    A + R SQP +G +  R   DE+ L+++  AN    +  L ++D RP +NA AN A G G E++  Y +I ++FL I NIHVMR S+ KL D+   +      +   LE + WL +I+ IL  S  VA
Sbjct:   70 AGGPLLLLHTKTFRSLHLKFQCEQDCQD-VQLSIVKLCRP-AHHRDLFAFSYSPRVRATDREEGWTLLDLRSEFRRMGVPNKHWKLTDINANYEVCGTYPADLFVPC-ISTDIVLGSARFRSKARFPTLSYLHAHNGAAICRCSQPLSGFS-TRCAEDEQLLQAVWRANPGPGHETLYVVDTRPKLNAMANRAAGRGYENEENYANIRFEFLGIENIHVMRSSLAKLLDVSQARGLSQREFVSGLEASGWLRHIQTILQASTAVA 330          

Query:  957 ANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNS---NWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQR---------RTNEVYTKTL-SFWDHVNSDIEK----YRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPESDEETNIAQPAGEARQ 1895
            A+ ++G GI+ + ++       +  P++  ++ S +KL   C P    S    ++K+LEE++WL  I+++L  + +V E ++   SV+V   +GWD T Q+ S+ QL+ DP++RT+ GF+ L++KEW+  GH+ S R+        + +  SQ S  AP+FLQF+DCV Q+  QF   FEFN+ +L  L     S  F  FL +S+ +R         +  ++ +K   S WD+V   I K    + N ++ PAD  G  VL P   L C+R W  YY+    +S  + P  D+  I  R               D  + + QP G   Q
Sbjct: 1351 ADKSQGKGIKFEGVH-GCEVLLVEYPDVRAVKASFKKLLRACVPSTSPSQDMTFYKSLEESEWLQQIQRLLQLAELVVELLDGGSSVMVSLEEGWDITTQLVSMVQLLSDPFYRTLDGFRLLVEKEWISFGHRFSHRS--------NQTLASQGSGLAPLFLQFLDCVHQVHNQFPTEFEFNQYYLKFLAYHFVSNRFRTFLLDSDYERIEMGMMYEEKGEKLGSKPARSLWDYVER-IHKTSPVFYNYMYMPAD--GEEVLQPFSMLACLRVW-DYYVE---ESLGEGPSFDWELINGR--------------CDVASEVEQPDGTVPQ 1650          

Query:  633 ESNNWRISKVNHNFEVCE--TYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQP 833
            +S  +RIS VN  +  C   +YP  + VP++V D T+    +   +NRFPV+CW H  TKA L RSS P
Sbjct: 1138 KSEIYRISTVNRMYGTCRRCSYPGLLIVPQNVQDSTLQKISRCYRQNRFPVICWRHSQTKAVLLRSSGP 1206          

Query:  612 EYQRQLIESNN----WRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYL----KSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYT-----------------SISYDFLNIPNIHV-------MRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLG-SLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSST-------------------------SQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLI-------DLMDAVYSGL-------------------------FGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESG 1679
            E++RQ ++S +    WR+S VN ++E C TYP ++ VP+  SD  + +A +FR++ R PVL + H  T   + RSSQP  GL  +R+  DE+ +     S  + +       I+DARP  NA A MA GGG E+ + Y                  +++  FL I NIH+       M E + +  DL  P     N  ++ + + WL     IL    +++   I +  +VLVHCSDGWDRT+Q+ SL ++ LDP++RT  GF  L++K+W   GH+  +R+G L  +     +T                         ++  E        I+ + +I+++F   F+ N++ L          +D VY  L                         +G FL NSE+++    +  KT S WD+  S  +++ NP F     SG
Sbjct:  164 EFRRQGLDSKDETCPWRLSTVNEHYEFCPTYPSKLFVPRSTSDILLKHASKFRSQKRIPVLTYHHKATDCNILRSSQPLPGLINQRSIQDEKLVWESFNSFCNKDIRRTKHVIVDARPRTNALAQMALGGGTENMDNYNFFLADNNMGVDKSLKLPTVTRLFLGIDNIHIVSNTAAYMTEVICQGGDLNLPL--EQNLIRSQKFSNWLKLNTLILKSVDMLLKSIIFNHSNVLVHCSDGWDRTSQVVSLLEICLDPFYRTFEGFMILVEKDWCSFGHRFLERSGHLNSDIRFHDNTMHSNFNDVDTNGDDLDIGVNTQDDYAEDDEGGEDETNLIN-LSRISKKFNENFKLNKKSLKFVSPVFQQFLDCVYQLLTQNPDLFEFNERFLRRLVYHLYSCQYGTFLSNSEKEKFQQNLPNKTKSVWDYFRSRRKQFINPNFIQRKRSG 606          

Query:  183 GENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLR 1745
            GE       +VT     T    G L +TNY+L F + +          +IP +++        +P+G I   EK  G          L I CKDFR++    K +++S     + +  Y  P S     FA+   D      G+       E++R  + ++ W ++++N  +E+ +TYP  V VP  VSDE I     FR++NR PVLCW+HP   A++TR+SQP  GL   RN+ DE+Y ++I +AN   + L I DARP INA AN A+GGG E++  Y +    FL+I NIHVMRES+RKL D+C+P  D+++W   LE TKWL++I+ I+ G++ +A+ ++  R SV+VHCSDGWDRT Q+T+L  L++DPY+RTI GF+ LI+KEWL  GHK +QR       +G         +R+P+FLQFIDCVWQ+T+QF  AFEFNE FLI ++D +YS +FG FL+NSE QR   +V T+T S W ++N+ + +++NPL+ P       VLFP   L  +  W  YY+R
Sbjct:   43 GEKPQATAKDVTYLCPFTGPVRGFLYITNYKLFFKADD----------DIPFTVE--------VPLGTIYRVEKIGGTTSRGENAYGLEIYCKDFRNLRFAHKQENHSRRLIYERIMHYAFPASNGKPYFAYSFKDEFEYN-GWDVYDAEKEFERLGLPTDCWYVTRINEKYELSDTYPAVVGVPSSVSDEDIKKVAVFRSRNRLPVLCWLHPTNNASITRASQPNRGLL-ARNKDDEKYFQAILEANPQCHKLLIFDARPRINAVANQAKGGGYETEENYQNTEVIFLDIANIHVMRESLRKLKDICFPNIDDTHWLTNLENTKWLDHIKMIMAGAVRIADAVDRCRTSVVVHCSDGWDRTPQLTALAMLLMDPYYRTIIGFEVLIEKEWLSFGHKFNQR-------YGHGDKNHADDQRSPVFLQFIDCVWQVTRQFPCAFEFNETFLITILDHLYSCMFGTFLYNSESQREKEDVKTRTTSLWSYINTSMMEFKNPLYAPYLH--QHVLFPVPSLRRLELWTRYYIR 543          

Query:  228 FSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVH---FDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLC--YPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRH 1748
            FS K   G L LT   L+F     +  G    + + + I   + L LN             G+ L I+CK F++ TL +  +    D +  LL  + + R +   L+AF +    + + +  G+    +  +Y R  + S+ W  +++N ++E+C+TYP+ + VPK  + E +  + +FR++ R PVL + H  T+A + R SQP  G    R   DE+ ++++ ++N  +  + I+D RP +NA AN A G G ES++ Y ++ + F+ I NIHVMR+S+ K+ ++    PK     ++  LE + WL +I+ IL  S+ +A+ +  ++ SVLVHCSDGWDRTAQ  SL  ++LDPY+RTI GFQ LI+KEWL  GHK + R G L          S + E +P+FLQF++ +WQ+ QQF  +F+FNE+FL+ L D VYS  FG FL N +++RR   +  +T S W ++  +I  Y NPL+    +     L+P      IRFW++ Y R+
Sbjct:   22 FSKKVSRGTLYLTPTHLIF----VDPVGAKETWILHSHILSLEKLPLN-----------AAGSPLRIRCKTFQNATLIIPKEKECHDIYTALL--FFSNREKLEDLYAFSYSPQTEKLTQSAGWALFDIKSDYTRMGVPSDLWTATQLNKDYELCDTYPNILYVPKSATKEVLVGSSRFRSRGRLPVLSFYHKSTQAAVCRCSQPLGGFK-GRCPEDEQMIQALLNSNPNSKFIYIVDTRPRLNALANRAAGKGYESEDFYENVKFQFVGIENIHVMRQSLFKMLEVVGESPKTPAGAFYSGLEASNWLKHIKNILDTSVFIAKAVAMEKASVLVHCSDGWDRTAQTCSLASIILDPYYRTIHGFQVLIEKEWLSFGHKFTDRCGLL---------QSDQKEFSPVFLQFLESIWQLLQQFPFSFQFNERFLLTLHDHVYSCQFGTFLGNCQKERRDLGLPKRTYSLWGYMWQNISDYANPLYREVTQDD--ALWPDTSPQAIRFWRAMYNRY 505          

Query:  204 ENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNS--------VLSDEYQRQLIES---NNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDA------------------NAYN-------------------------NLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQ-RSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADE 1673
            E N    +F T   +  L L+N+RL                        FK   LN+P+  I+  E  D   L + CKD RS  +   ++  SVD   K+  K + P S    LFAF H+      P    S           +E  R   E+   + WRIS  N +FEVC TYP    +P  +SD  +     FR   RFP + W H    A + R SQP  G    R+  DE  L++I  A                  N  N                           + I+DAR    A AN  +GGG E    Y +    F+N+ NIH +R S   L  LC    D  NW   +E+T WL++I  ++  ++ +   +++  R V+VHCSDGWDRT QI +L +L+LDP++RTI GF+ LID+EWL  GH+ + R G          S   ++ER P+FLQ++DCV Q+ +QF ++FEF+E +LI L+   YS LFG FL N+E  R T+ +  +TLS W ++    + +RN L+    +
Sbjct:   35 ELNGECVEFLTATADATLALSNFRLFI---------------------TFKCSFLNIPLMLIESVELRDLFILQVNCKDARSFRIVFDSNDQSVDWLHKVSAKIL-PYSRIEDLFAFAHYAWSMASPNSFTSQDASATPYSFLEEVHRMGFETGVDSPWRISDANSSFEVCRTYPRLHVIPSSISDSDLAKVASFRCSGRFPSIVWRHMTNGAVIARCSQPQVGWLGWRSAEDELLLQAIGQACTSDRYPSVAKLLNGITVNGINKKHDMGDVLNGPADMSEDGPIARNPKQVLIVDARSYTAAYANRGKGGGFEYTEYYPNCEVMFMNLANIHGIRRSFHSLRALCSGSYDVPNWWSLIEKTNWLHHISMLIKSAVTIVHAVHTDGRPVVVHCSDGWDRTTQIVALAELLLDPFYRTIEGFKILIDREWLQFGHRFADRCG--------HGSDIDENERCPVFLQWLDCVHQLQKQFPSSFEFSETYLIKLLHHTYSCLFGTFLGNNEHGRHTDAIKARTLSVWSYILPRKKDFRNLLYAGGGD 549          

Query:  207 NNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEK---GDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKL-FAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATG-LTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKA-LEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSD--IEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQD 1772
            +NV L   +T    G L +T + L+F                  S +  +S +L L +  ++  EK   G    LTI CK+F  V +++ ND          ++      ++ +K  F + H  A+  E G+       ++ +    + +WRIS VN N+EVC +YP  V VP  VSD+ +  + QFR   RFPVLC+ H  T++ L RS +P  G ++ KR + DE+ + S   +        I+D R       + ++GGG+E ++ Y        NI    V+ +S+ KL + C+ +  + N + + LE   W++ I+ +L  +  VA  +++    VLVH   G D T Q+TSL Q++LDP  RT+RGFQ+L+D+EW+  GH  S R   +   F ST    Q     P+FL F+DCVWQI QQF  +FEF++ FLI L +  Y   FG FL N+E+ R T ++  KT+S W ++N D  +E   NP++    E    VL+P      +  W   YL+   Q R+ D
Sbjct:   13 DNVLLKRRNTPYIEGTLCITGHHLIF------------------SSRTQRSEELFLLISGVEHVEKKFVGQEAILTICCKNFDLVKMRI-NDMEKALNLISTIDALSTLENQTLKYPFFYRHVGALSGEDGWDMFSNDLDFAKVCSSTQSWRISHVNINYEVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSNKRCKEDEKLVNSALGSMKKG---MIVDTRSTPAVMNSRSKGGGLEPESNYPQWKRSNHNIEKHTVLIDSVCKLMEACFDQNLSMNAYLSRLESCGWMDQIQAVLGTACYVAHCLHTDGIPVLVHDGAGLDATLQVTSLSQVILDPDCRTVRGFQSLVDREWIRGGHPFSNRCTRVG--FSSTKYKGQ----GPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFGTFLCNNEKNRVTVKLKEKTISLWSYLNQDEILEDMLNPMY----ERNESVLWPSVAPQSLVLWPGLYLKWQKQQRNGD 511          

Query:  999 YTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRH 1748
            Y   S  FL+IPNIH +R+S+ +L  +C        W   LE T+WL YI  IL G+  +A  ++   S LVHCSDGWDRT+Q+T L QL+LDPY+RT  GFQ LI+KEW+  GH+   R G  T            S+R+PIFLQF+DCVWQ+ +QF +AF+F   +L+ L D V S  FGNFL+N+ Q+R    +   T+S W H+N+  + Y N ++ P +      L P   L  ++ W  Y+LR+
Sbjct:    1 YQGCSLVFLDIPNIHAVRDSLDRLQAVC-ESSSQKKWLSHLESTQWLAYIAAILKGATTIARFVDKGVSTLVHCSDGWDRTSQLTLLAQLLLDPYYRTFTGFQVLIEKEWISFGHRFRDRLGHPT----------CPSQRSPIFLQFLDCVWQVHKQFPSAFQFTANYLLKLADHVNSQWFGNFLYNNVQERHHAFITRTTVSLWSHLNAVKDNYTNSIYQPTE-----TLVPVSSLRRLQLWSDYFLRY 234          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGN---CLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            G +MLTNYRL F                  S +   +  L++P+G ++  E    +      I CKD R++    K    +     +++ K+  P S  ++LFAF H+  +  E G++      EY+RQ I + +WRI+K+N ++E+C+TYP  + VP ++ D+ +     FR K R PVL WIHP+++AT+TR SQP  G+  KR + DE+YL++I DANA ++ L I DARP ++A AN  +GGG+ES++ Y +    FL+I NIHVMRES+RK+ +  YP  D+++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRT Q+TSL  LMLD Y+RTIRGF+ LI+KEWL  GH+  QR G      G  + T   +ER+P+F+QF+DCVWQ+T+QF +AFEFNE FLI +++ ++S LFG FL N EQQR   EV  KT+S W ++NS +E++ NP +   + S H VLFP   L  +  W SYY+R   + R Q+P+   Y  +L++R  +
Sbjct:   53 GTVMLTNYRLFF-----------------KSTEREPTFMLDMPLGVVRRVEIYRTHRDVSYDIICKDTRNLRFLQKYPEETKKSIFEVMTKFAFPVSNGLQLFAF-HYQQVFPENGWKVYDALAEYKRQGIPNESWRITKINDHYELCDTYPASLVVPVNIPDDELKKVAAFRGKGRIPVLSWIHPESQATVTRCSQPMAGVNGKRCKEDEKYLQAIMDANAQSHKLFIFDARPNVSALANKMKGGGVESEDAYQNAELVFLDIHNIHVMRESLRKVKEAIYPNIDDAHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTTQLTSLAMLMLDGYYRTIRGFEILIEKEWLSFGHRFQQRIG-----HGDKNYTD--AERSPVFVQFVDCVWQLTRQFPSAFEFNEYFLITILEHLFSCLFGTFLCNCEQQRLKEEVPKKTVSLWSYINSQLEEFTNPFY--VNYSNH-VLFPVVSLHHLELWVSYYIRWNPRMRPQEPLHQRYKELLAKRAEL 552          

Query:  249 GLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGN---CLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIAD-YSRILSRRKRI 1817
            G +MLTNYRL F                  S +   +  L++P+G ++  E    +      I CKD R++    K    +     +++ K+  P S  ++LFAF H+  +  E G++      EY+RQ I + +WRI+K+N ++E+C+TYP  + VP ++ D+ +     FR K R PVL WIHP+++AT+TR SQP  G+  KR + DE+YL++I DANA ++ L I DARP ++A AN  +GGG+ES++ Y +    FL+I NIHVMRES+RK+ +  YP  D+++W   LE T WL +I+ IL G+L +A+K+ S + SV+VHCSDGWDRT Q+TSL  LMLD Y+RTIRGF+ LI+KEWL  GH+  QR G      G  + T   +ER+P+F+QF+DCVWQ+T+QF +AFEFNE FLI +++ ++S LFG FL N EQQR   EV  KT+S W ++NS +E++ NP +   + S H VLFP   L  +  W SYY+R   + R Q+P+   Y  +L++R  +
Sbjct:  104 GTVMLTNYRLFF-----------------KSTEREPTFMLDMPLGVVRRVEIYRTHRDVSYDIICKDTRNLRFLQKYPEETKKSIFEVMTKFAFPVSNGLQLFAF-HYQQVFPENGWKVYDALAEYKRQGIPNESWRITKINDHYELCDTYPASLVVPVNIPDDELKKVAAFRGKGRIPVLSWIHPESQATVTRCSQPMAGVNGKRCKEDEKYLQAIMDANAQSHKLFIFDARPNVSALANKMKGGGVESEDAYQNAELVFLDIHNIHVMRESLRKVKEAIYPNIDDAHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTTQLTSLAMLMLDGYYRTIRGFEILIEKEWLSFGHRFQQRIG-----HGDKNYTD--AERSPVFVQFVDCVWQLTRQFPSAFEFNEYFLITILEHLFSCLFGTFLCNCEQQRLKEEVPKKTVSLWSYINSQLEEFTNPFYV--NYSNH-VLFPVVSLHHLELWVSYYIRWNPRMRPQEPLHQRYKELLAKRAEL 603          

Query:  150 NLLQEVYDFKCGENIV-KEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNC--------LTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLR--HYLQSRSQDPIAD-YSRILSRR----KRIFQTQL 1832
            +LL  V      E I+ K+   +  F+ + KG+   +++TNYRL F                 NS+     + L++P+G I   EK  G          L I CKD R++   LK + +S     +LL +Y  P S    LFA+++ +    E G+      +E++RQ + +N WRI+ +N N+E+C+TYP  +AVP   ++E +     FR++ R PVL WIH + KA + R SQP  G++ KRN+ DERYL  I++AN    L TI DARP +NA AN A GGG E    Y +    FL+I NIHVMRES++KL D+ YP  + S+W  +LE T WL +I+ +L G++ VA+K++   SV+VHCSDGWDRTAQ+TSL  LMLD +FRT+RG Q LI+KEW+  GHK + R G      G  + T Q  +R+PIF+QFIDCVWQ+T+QF  AFEFNE  L+ ++D +YS  FG FL+N E  R  NEV TKTLS W  VNS +E Y NP +TP  ESG RVL+P   +  +  W +YY+R    +Q + Q P+   Y  +L+ R    K++ Q Q+
Sbjct:   27 DLLANVSLLPGEERIIDKDVIYICPFNGAVKGK---VLITNYRLYF-----------------NSVDLDVLVSLDVPLGAISRVEKMGGASSRGENSYGLDITCKDMRNLRFALKQEGHSRRDLFELLFRYAFPLSHGSPLFAYLNQEKF-PENGWSIYKPVEEFRRQGLPNNKWRITFINKNYELCDTYPTVLAVPFKSTEEDLKRVATFRSRGRIPVLSWIHRENKAVIVRCSQPLVGMSGKRNKDDERYLDLIREANDTTKL-TIYDARPSVNAVANKATGGGYEGDE-YQNAELVFLDIQNIHVMRESLKKLKDIVYPTVEESHWLSSLESTHWLEHIKLVLSGAIQVADKVSGGHSVVVHCSDGWDRTAQLTSLAMLMLDSHFRTLRGLQVLIEKEWISFGHKFASRIG-----HGDKNHTDQ--DRSPIFVQFIDCVWQMTKQFPTAFEFNENLLLTILDHLYSCRFGTFLYNCESARDQNEVRTKTLSLWSLVNSKMEIYLNPFYTP--ESG-RVLYPVASMRHLELWVTYYIRWNPRIQHQQQSPVEQRYRELLALRDEYLKKLEQLQM 570          

Query:  246 NGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPV-------GFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPE 1847
            +G L +T+Y+L F S       +S F            LD+NL V        F  + E   G  L + CKD RS     K +       D +L KY+ P S N+ LFAF + +    + G++    + EY+RQ + + +W IS+VN  +E+C+TYP  + +P ++++E +     FR ++R PVL WIHP+++AT+ R SQP  G + +R + DER L+ I DANA ++ LTI DAR    A +N A+ GG ES++ Y +    FL IPNIHV+RES RKL D+ YP  D ++WH A+++T WL YIR +L G+  VA K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RT+ GFQ L++KEW+  GHK   R G   ++          SER+P+F+QF+DCVWQ+T+QF +AFEFNE FLI ++D +YS LFG FL NSEQ+R   EV TKT S W ++NS  E + NP +   +   + VL+P      +  W  Y+ R     RSQ P+    + L     I + +L R+ E
Sbjct:  111 SGTLTITDYKLYFTSGEK----ESPFV-----------LDINLGVISRLEAISFPDQEEMTKG--LELVCKDMRSPRFAFKFEETQPSVVD-VLNKYVFPLSHNLPLFAFQYKETFPAD-GWKVYDAAAEYRRQGLPNESWTISRVNSIYELCDTYPSTLVIPTNITEEDLKRVASFRARHRVPVLSWIHPESQATIVRCSQPLVGPSDRRCKEDERLLQVIMDANAQSHKLTIFDARQSSVAISNKAKDGGFESESFYANAELIFLEIPNIHVIRESQRKLKDMLYPTIDEAHWHSAIDQTHWLEYIRLLLAGAAKVAHKVESGKSSVVVHCSDGWDRTAQLTSLSMLMLDGYYRTLTGFQVLVEKEWISFGHKFCARVGHGDKDHAD-------SERSPLFVQFVDCVWQMTRQFPSAFEFNELFLITVLDYLYSCLFGTFLCNSEQERVAQEVQTKTASLWSYINSQSEDFTNPFY---ENYQNHVLYPLASSRHLELWTGYHARWNPHMRSQVPVHQTLKEL----LILRAELQRKVE 619          

Query:  246 NGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPV-------GFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPE 1847
            +G L +T+Y+L F S       +S F            LD+NL V        F  + E   G  L + CKD RS     K +       D +L KY+ P S N+ LFAF + +    + G++    + EY+RQ + + +W IS+VN  +E+C+TYP  + +P ++++E +     FR ++R PVL WIHP+++AT+ R SQP  G + +R + DER L+ I DANA ++ LTI DAR    A +N A+ GG ES++ Y +    FL IPNIHV+RES RKL D+ YP  D ++WH A+++T WL YIR +L G+  VA K+ S + SV+VHCSDGWDRTAQ+TSL  LMLD Y+RT+ GFQ L++KEW+  GHK   R G   ++          SER+P+F+QF+DCVWQ+T+QF +AFEFNE FLI ++D +YS LFG FL NSEQ+R   EV TKT S W ++NS  E + NP +   +   + VL+P      +  W  Y+ R     RSQ P+    + L     I + +L R+ E
Sbjct:  132 SGTLTITDYKLYFTSGEK----ESPFV-----------LDINLGVISRLEAISFPDQEEMTKG--LELVCKDMRSPRFAFKFEETQPSVVD-VLNKYVFPLSHNLPLFAFQYKETFPAD-GWKVYDAAAEYRRQGLPNESWTISRVNSIYELCDTYPSTLVIPTNITEEDLKRVASFRARHRVPVLSWIHPESQATIVRCSQPLVGPSDRRCKEDERLLQVIMDANAQSHKLTIFDARQSSVAISNKAKDGGFESESFYANAELIFLEIPNIHVIRESQRKLKDMLYPTIDEAHWHSAIDQTHWLEYIRLLLAGAAKVAHKVESGKSSVVVHCSDGWDRTAQLTSLSMLMLDGYYRTLTGFQVLVEKEWISFGHKFCARVGHGDKDHAD-------SERSPLFVQFVDCVWQMTRQFPSAFEFNELFLITVLDYLYSCLFGTFLCNSEQERVAQEVQTKTASLWSYINSQSEDFTNPFY---ENYQNHVLYPLASSRHLELWTGYHARWNPHMRSQVPVHQTLKEL----LILRAELQRKVE 640          

Query:  138 MIGKNLLQEVYDFKCGENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPESDEETNIAQPAGEARQI 1898
            MIGKNLLQEVYDFKCGENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNS DRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGY NSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPESDEETNIAQPAGEARQI
Sbjct:    1 MIGKNLLQEVYDFKCGENIVKEENNVTLFDFSTKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSADRFDKLLEKYMNPRSENIKLFAFVHFDAMHKEPGYSNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRILSRRKRIFQTQLNRQPESDEETNIAQPAGEARQI 587          

Query:  246 NGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENI------KLFAFVHFDAMHKEPGYR--------------NSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDA---NAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQ-RSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESG------HRVLFPQY 1703
            N  + LTNYRL F   N+                  K   + +P+  + + E+ D   LT+  K       KL  DS+ +         ++   SEN+      K+FAF  F+++ K    +              + VL  E++R    +  W+I+ VN  F+VC +YP    VP  +SDE I    +FR   RFP + W      A + R +QP  GL + RN  DE + K +      N     L IIDAR    A+ N  RGGG+E    Y      F+ + NIH +R S   ++       +  NW  ++E + WL Y+ ++L  +  +A  +N   RSV++HCSDGWDRT Q+TSL Q++LD ++RTI+GF+ LI++EW+  GHK S R G         + +    E +PIF+Q++DC+ Q+ +Q+   FEFNE FL+ L   VYSGLFGNF+FNSE++R+ N VY+ T   W+ ++   E   NPLF     +        +V++P+Y
Sbjct:   30 NYTMSLTNYRLCFICKNNVD----------------KICHIGIPLNLLLKIEQVDFKHLTLWTK--VGSVYKLSFDSSDI------CHDWLMNISENLNIKTSGKMFAFNFFESLEKLKSEKWLLYGIKQKSKSSDSKVLKKEFKRMKFSNKIWKITDVNKKFQVCNSYPPYHIVPCSISDEDIKAMAEFRGNKRFPSVVWRSQKNGAVIIRCAQPQVGLMFWRNSFDETFFKEVLKCLKCNGNKKRLLIIDARHYSTAQFNRIRGGGVEYSEYYGEAEIVFMQLENIHSVRSSFDCISMF---SMNGENWFTSIENSCWLKYLSKLLKSACDIARALNEDGRSVIIHCSDGWDRTPQLTSLSQILLDDFYRTIKGFKVLIEREWIHFGHKFSDRCG--------FNKSVDNKEWSPIFVQWLDCIHQLIRQYPCYFEFNETFLVKLALHVYSGLFGNFMFNSEEERQNNGVYSSTACIWNFLSESNEDIINPLFYKFSVAETNFDVYKKVIYPKY 510          

Query:  255 LMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENI------KLFAFVHFDAMHKEPGYR--------------NSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDA---NAYNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQ-RSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESG------HRVLFPQY 1703
            + LTNYRL F   N+                  K   + +P+  + + E+ D   LT+  K       KL  DS+ +         ++   SEN+      K+FAF  F+++ K    +              + VL  E++R    +  W+I+ VN  F+VC +YP    VP  +SDE I    +FR   RFP + W      A + R +QP  GL + RN  DE + K +      N     L IIDAR    A+ N  RGGG+E    Y      F+ + NIH +R S   ++       +  NW  ++E + WL Y+ ++L  +  +A  +N   RSV++HCSDGWDRT Q+TSL Q++LD ++RTI+GF+ LI++EW+  GHK S R G         + +    E +PIF+Q++DC+ Q+ +Q+   FEFNE FL+ L   VYSGLFGNF+FNSE++R+ N VY+ T   W+ ++   E   NPLF     +        +V++P+Y
Sbjct:    1 MSLTNYRLCFICKNNVD----------------KICHIGIPLNLLLKIEQVDFKHLTLWTK--VGSVYKLSFDSSDI------CHDWLMNISENLNIKTSGKMFAFNFFESLEKLKSEKWLLYGIKQKSKSSDSKVLKKEFKRMKFSNKIWKITDVNKKFQVCNSYPPYHIVPCSISDEDIKAMAEFRGNKRFPSVVWRSQKNGAVIIRCAQPQVGLMFWRNSFDETFFKEVLKCLKCNGNKKRLLIIDARHYSTAQFNRIRGGGVEYSEYYGEAEIVFMQLENIHSVRSSFDCISMF---SMNGENWFTSIENSCWLKYLSKLLKSACDIARALNEDGRSVIIHCSDGWDRTPQLTSLSQILLDDFYRTIKGFKVLIEREWIHFGHKFSDRCG--------FNKSVDNKEWSPIFVQWLDCIHQLIRQYPCYFEFNETFLVKLALHVYSGLFGNFMFNSEEERQNNGVYSSTACIWNFLSESNEDIINPLFYKFSVAETNFDVYKKVIYPKY 478          

Query:  582 PGYRNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANAYNNL------LTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQR-SVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVY---TKTLSFWDHV-NSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYL 1742
            P     +++ E+ R     + WRIS +N  F++C TYP    VPK   D  I    +FR+K RF  + +   +    + RS QP TG++  RNE+DE+Y   I D      L      L I DAR   +A+ N  +GGG+ES+  Y+  S +FLNIPN+H +R S          + D+ N+++ + ++ WL  IRQ++  +  + + +  ++ SVL+HCSDGWDRT Q+ SL Q+++DPY+RTI GF+ LI +EW+L GHK ++R      +F          E +PIF+Q++DCV+Q+ QQF   F FNE FLI L   VYSG+FG F          N V    T+T S W  +   ++  + NPL++P      +++ P++++  I+ W + Y 
Sbjct:   45 PNNEKEIITKEFDRMQFSGDFWRISSINEEFKICSTYPQYHIVPKSFPDNLIKEMAKFRSKGRFISVSYRSIEAGTVMLRSGQPLTGVSCWRNEADEKYFHVINDNRTCEVLETEGLQLKIYDARSYTSAQLNRVKGGGMESETNYSIKSLEFLNIPNMHAVRNSFESFTKALL-ENDSDNFYELIFKSNWLQLIRQLIKSASQITDTMCIKKISVLIHCSDGWDRTPQLVSLSQILMDPYYRTIEGFRILIYREWILFGHKFNERCALWPVDFS--------REYSPIFVQWLDCVYQLLQQFPDYFHFNETFLIKLAIHVYSGMFGTF----------NTVISNTTETCSLWSFLCQKEMHDFINPLYSP--HKTFKLIKPKFQMSNIKLWNNLYF 421          

Query:  207 NNVTLFDF--STKGQNGLLMLTNYRLLFWSYNSNSFGKSHFYEIPNSIKEFKSLDLNLPVGFIQEFEKGDGNCLTIKCKDFRSVTLKLKNDSNSVDRFDKLLEKYMNPRSENIKLFAFV-HFDAMHKEP-GY--RNSVLSDEYQRQLIESNNWRISKVNHNFEVCETYPDEVAVPKDVSDETITNACQFRTKNRFPVLCWIHPDTKATLTRSSQPATGLTWKRNESDERYLKSIKDANA--YNNLLTIIDARPMINARANMARGGGIESQNIYTSISYDFLNIPNIHVMRESMRKLADLCYPKPDNSNWHKALEETKWLNYIRQILLGSLMVAEKINSQRSVLVHCSDGWDRTAQITSLPQLMLDPYFRTIRGFQTLIDKEWLLMGHKISQRTGGLTEEFGSTSSTSQKSERAPIFLQFIDCVWQITQQFLAAFEFNEQFLIDLMDAVYSGLFGNFLFNSEQQRRTNEVYTKTLSFWDHVNSDIEKYRNPLFTPADESGHRVLFPQYRLPCIRFWKSYYLRHYLQSRSQDPIADYSRI 1796
            +NV L D   S+ G  G L +T   L+F S                 +KE K + ++L            G  L I  KDF      ++ D+N  D+   +L K +    ++ KL  F  + +    +P G+   N  L+  + R  I +  W  + +N N+++ +TYP  + +P   S   +    +FR++ RFPVL + +   K+ L R SQP  G + +  E D   LK IKDA +  +++ L ++D RP INA  N ARG G ES   Y  I + F  I NIHVMR S+ KL   C     +   H  ++++ WL +I+ I   SL +A+K+    +V+VHCSDGWDRT+Q+  L Q+++DPY+RTI G + +I+K+WL  GHK S R G L        S+   +E +P+F QF+DCV+Q+ ++F   F++NE+ L  L       +FG F+ N E+ R   + Y +  S W +V +++  Y NP +   +    +VL    R     FW + Y           PI D S +
Sbjct:   10 DNVRLLDSYESSIGIKGKLHITVSHLIFLS---------------EDLKEEKWILIHLISSIDSPSVNSMGKVLIISLKDFHIYRFVIE-DNNGSDKLRLVLLKLIANVDQHSKLPCFSPNSNQQFPQPIGWILSNKRLTSSFMRMGIPNRQWEFTDINTNYKMSDTYPSVIVIPVGTSKAIMEACSKFRSRGRFPVLSYYYSPAKSALCRCSQPLVGFSARCTE-DITMLKRIKDAASEEHSDKLHVVDTRPKINALTNRARGKGYESDIDYEKIVFQFFQIENIHVMRSSLEKLLKACRNMRQSHLSH--VDKSGWLKHIKWIYDASLYIAQKLLLGENVVVHCSDGWDRTSQVCGLTQIIIDPYYRTIEGLEDVIEKDWLSFGHKFSDRCGHL--------SSVDPTEISPVFTQFLDCVFQLLKKFPNQFQYNERLLRHLHRWSQDCVFGTFVGNCEKDRLDLKNYERCYSVWGYVKNNLWDYLNPYYDSNEII--KVLDEPLRNSDFSFWSALYC----------PIEDLSTV 508