Mitogen-activated protein kinase kinase kinase 3

Overview
NameMitogen-activated protein kinase kinase kinase 3
Smed IDSMED30007714
Length (bp)1815
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mitogen-activated protein kinase kinase kinase 3 (SMED30007714) t-SNE clustered cells

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase kinase 3 (SMED30007714) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mitogen-activated protein kinase kinase kinase 3 (SMED30007714) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase kinase 3 (SMED30007714) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30007714

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
neoblastSMED30007714SMESG000016834.1 dd_Smed_v4_7460_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30007714SMESG000016834.1 dd_Smed_v4_7460_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30007714SMESG000016834.1 dd_Smed_v4_7460_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30007714SMESG000016834.1 dd_Smed_v4_7460_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 179.874 bits (455), Expect = 2.586e-48
Identity = 100/263 (38.02%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L++ RIVQY+G ++  +E  L IFME++P GS+ D++    ++      +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F+  +   + + RP+A ELL   F
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQ-LLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 621
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 179.874 bits (455), Expect = 2.785e-48
Identity = 100/263 (38.02%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L++ RIVQY+G ++  +E  L IFME++P GS+ D++    ++      +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F+  +   + + RP+A ELL   F
Sbjct:  358 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQ-LLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 617
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 180.259 bits (456), Expect = 3.157e-48
Identity = 100/263 (38.02%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L++ RIVQY+G ++  +E  L IFME++P GS+ D++    ++      +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F+  +   + + RP+A ELL   F
Sbjct:  393 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQ-LLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 652
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 180.259 bits (456), Expect = 3.157e-48
Identity = 100/263 (38.02%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L++ RIVQY+G ++  +E  L IFME++P GS+ D++    ++      +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F+  +   + + RP+A ELL   F
Sbjct:  393 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQ-LLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 652
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 180.259 bits (456), Expect = 3.382e-48
Identity = 100/263 (38.02%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L++ RIVQY+G ++  +E  L IFME++P GS+ D++    ++      +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F+  +   + + RP+A ELL   F
Sbjct:  389 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQ-LLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 648
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 144.821 bits (364), Expect = 1.691e-36
Identity = 93/272 (34.19%), Postives = 150/272 (55.15%), Query Frame = 3 
Query:  858 CDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKR--DIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKI-GNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
             + KL P+ +    F + E IG G+FG V+    +   R  AIK I+  + +    DI+  I   L    +  + +YFG+    S+L I ME+L  GS  D +++   +   ++    R+IL+GLE+LH ++ IHRD+K  N+L+ +  ++K+ADFG++  L  T    I   +F G+P + APE++    Y+  ADIWSLG T I +   +PP+ DL  P  V+F I  N   +   S  S+  + F+   L  DP++RP+A+ LLK +F+
Sbjct:    4 ANSKLDPEVI----FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQ-VLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRI---TFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLH-PMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 265
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 144.821 bits (364), Expect = 2.008e-36
Identity = 90/258 (34.88%), Postives = 144/258 (55.81%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKR--DIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKI-GNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            F + E IG G+FG V+    +   R  AIK I+  + +    DI+  I   L    +  + +YFG+    S+L I ME+L  GS  D +++   +   ++    R+IL+GLE+LH ++ IHRD+K  N+L+ +  ++K+ADFG++  L  T    I   +F G+P + APE++    Y+  ADIWSLG T I +   +PP+ DL  P  V+F I  N   +   S  S+  + F+   L  DP++RP+A+ LLK +F+
Sbjct:   34 FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQ-VLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRI---TFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLH-PMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 285
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: nsy-1 (Mitogen-activated protein kinase kinase kinase nsy-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21029])

HSP 1 Score: 146.362 bits (368), Expect = 2.026e-36
Identity = 90/260 (34.62%), Postives = 145/260 (55.77%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNIN-SFLPMLKNARIVQYFG-----AIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRY-SRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKK-LELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            +G G +GTV+  +     R   +K I   K+D+    L    S    L +A IVQY G        +     IFME +P GSL+  +  +     +N + Y  +QILEGL++LH  KI+HRD+K  N+L++  + + K++DFG  +   R  G++  T++F GT  + APE++      Y  PADIWS G T++ M T +PP+ +++ P A +F++G  K    +P++I+E+ R FI     P+  DRP+A +LL+  F+
Sbjct:  656 LGKGTYGTVYAARDMDTQRQIVVKEIE-VKYDEEVQPLMEEISLHSTLCHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCK---RLAGLNPVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFI 911
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 144.821 bits (364), Expect = 2.137e-36
Identity = 90/258 (34.88%), Postives = 144/258 (55.81%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKR--DIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKI-GNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            F + E IG G+FG V+    +   R  AIK I+  + +    DI+  I   L    +  + +YFG+    S+L I ME+L  GS  D +++   +   ++    R+IL+GLE+LH ++ IHRD+K  N+L+ +  ++K+ADFG++  L  T    I   +F G+P + APE++    Y+  ADIWSLG T I +   +PP+ DL  P  V+F I  N   +   S  S+  + F+   L  DP++RP+A+ LLK +F+
Sbjct:   19 FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQ-VLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRI---TFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLH-PMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 270
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: nsy-1 (Mitogen-activated protein kinase kinase kinase nsy-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21029])

HSP 1 Score: 146.362 bits (368), Expect = 2.250e-36
Identity = 90/260 (34.62%), Postives = 145/260 (55.77%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNIN-SFLPMLKNARIVQYFG-----AIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRY-SRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKK-LELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            +G G +GTV+  +     R   +K I   K+D+    L    S    L +A IVQY G        +     IFME +P GSL+  +  +     +N + Y  +QILEGL++LH  KI+HRD+K  N+L++  + + K++DFG  +   R  G++  T++F GT  + APE++      Y  PADIWS G T++ M T +PP+ +++ P A +F++G  K    +P++I+E+ R FI     P+  DRP+A +LL+  F+
Sbjct:  670 LGKGTYGTVYAARDMDTQRQIVVKEIE-VKYDEEVQPLMEEISLHSTLCHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCK---RLAGLNPVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFI 925
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: GckIII (gene:FBgn0266465 transcript:FBtr0083399)

HSP 1 Score: 145.976 bits (367), Expect = 9.960e-37
Identity = 86/259 (33.20%), Postives = 143/259 (55.21%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKR--DIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            F + E IG G+FG VF    +   +  AIK I+  + +    DI+  I   L    +  + +Y+G+    ++L I ME+L  GS  D + +  S +  ++    R++L+GL++LH ++ +HRD+K  N+L+ ++ ++KLADFG++  L  T   +    +F GTP + APE++    Y+  ADIWSLG T I +   +PP  +L  P  V+F I      +L    ++  + F+   L  DP++RPTA ELLK  F+ +
Sbjct:   13 FTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEI-MVLSQCDSPYVTKYYGSFLKGTKLWIIMEYLGGGSALD-LMKAGSFEEMHIGIILREVLKGLDYLHSERKLHRDIKAANVLLSEQGDVKLADFGVAGQLTNT---TSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAKGEPPNSELH-PMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENRPTAKELLKYPFIKK 265
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: Mekk1 (gene:FBgn0024329 transcript:FBtr0083684)

HSP 1 Score: 145.591 bits (366), Expect = 5.111e-36
Identity = 97/319 (30.41%), Postives = 166/319 (52.04%), Query Frame = 3 
Query:  741 SPMVI-AERNKDLINMLNA----GVEARQLRQQISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPML---KNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNI-LMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMS---GDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            +P+ +  ER +D +N L+     G+  R+L  Q+ ++    NS     +  +S+  + +HRG +IG G FG V+    +      A+K I     + R ++ N+   L +L   K+  +V+Y+G      EL IFME    G+L   +    ++      R++ Q+L G+  LH   I+HRD+K  NI L+D  N++KL DFG +  +     +  + + + GT  + APE+ +    D +   ADIWS+G  ++ M + + P+   ++ + ++FK+G  +K + P  +S+E   FI   LQ DPK R TA ELL+  F
Sbjct: 1229 TPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSL----NSSDKVHIRARSVHFR-WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALK-NVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNF 1541
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: Mekk1 (gene:FBgn0024329 transcript:FBtr0331353)

HSP 1 Score: 145.591 bits (366), Expect = 5.250e-36
Identity = 97/319 (30.41%), Postives = 166/319 (52.04%), Query Frame = 3 
Query:  741 SPMVI-AERNKDLINMLNA----GVEARQLRQQISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPML---KNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNI-LMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMS---GDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            +P+ +  ER +D +N L+     G+  R+L  Q+ ++    NS     +  +S+  + +HRG +IG G FG V+    +      A+K I     + R ++ N+   L +L   K+  +V+Y+G      EL IFME    G+L   +    ++      R++ Q+L G+  LH   I+HRD+K  NI L+D  N++KL DFG +  +     +  + + + GT  + APE+ +    D +   ADIWS+G  ++ M + + P+   ++ + ++FK+G  +K + P  +S+E   FI   LQ DPK R TA ELL+  F
Sbjct: 1136 TPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSL----NSSDKVHIRARSVHFR-WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALK-NVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNF 1448
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: Ask1 (gene:FBgn0014006 transcript:FBtr0300256)

HSP 1 Score: 142.124 bits (357), Expect = 6.165e-35
Identity = 90/259 (34.75%), Postives = 143/259 (55.21%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFI---NYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDN---VIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENN-IKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGD--PYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKL-ELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            +G G +GTV+  +        AIK +   N         E+ ++S    L++  IV+Y G+        IFME +P GSL+D +  +     DN   +  YS+QILEGL++LH + I+HRD+K  N+L++  +  +K++DFG S+ L R + +   T++F GT  + APE++      Y   ADIWS G T + M T +PP+ +L +  A +FK+G  KK   +P ++S   + FIL        DRP+A++LL+  FL
Sbjct:  591 LGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHS---QLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPM---TETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFL 843
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: Ask1 (gene:FBgn0014006 transcript:FBtr0083819)

HSP 1 Score: 141.739 bits (356), Expect = 8.813e-35
Identity = 90/259 (34.75%), Postives = 143/259 (55.21%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFI---NYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDN---VIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENN-IKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGD--PYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKK-LELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            +G G +GTV+  +        AIK +   N         E+ ++S    L++  IV+Y G+        IFME +P GSL+D +  +     DN   +  YS+QILEGL++LH + I+HRD+K  N+L++  +  +K++DFG S+ L R + +   T++F GT  + APE++      Y   ADIWS G T + M T +PP+ +L +  A +FK+G  KK   +P ++S   + FIL        DRP+A++LL+  FL
Sbjct:  424 LGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHS---QLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPM---TETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFL 676
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 184.111 bits (466), Expect = 4.628e-50
Identity = 103/263 (39.16%), Postives = 151/263 (57.41%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K +++      T  +   +E  I   L  L + RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L      S   +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F L  +  + K RP+A ELL+  F
Sbjct:  344 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQ-LLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEA-MAAIFKIATQPTNPQLPSHISEHTRDF-LRCIFVEAKYRPSAEELLRHPF 603
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 183.341 bits (464), Expect = 9.315e-50
Identity = 103/263 (39.16%), Postives = 151/263 (57.41%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K +++      T  +   +E  I   L  L + RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L      S   +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F L  +  + K RP+A ELL+  F
Sbjct:  356 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQ-LLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEA-MAAIFKIATQPTNPQLPSHISEHTRDF-LRCIFVEAKYRPSAEELLRHPF 615
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 183.341 bits (464), Expect = 1.235e-49
Identity = 103/263 (39.16%), Postives = 151/263 (57.41%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K +++      T  +   +E  I   L  L + RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L      S   +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F L  +  + K RP+A ELL+  F
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQ-LLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEA-MAAIFKIATQPTNPQLPSHISEHTRDF-LRCIFVEAKYRPSAEELLRHPF 621
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 172.17 bits (435), Expect = 8.759e-46
Identity = 101/263 (38.40%), Postives = 152/263 (57.79%), Query Frame = 3 
Query:  909 GEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSF---LPMLKN---ARIVQYFGAIKT--ESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLL--IRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            G+ +G GAFG VF C  +   R  A+K + +   D  +    +++    + +LKN    RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG SR L  I   G  I  KS  GTP + +PE++SG+ Y   ADIWS+G T++ M+T +PP+ + E   A IFKI  +     LP  +S+  R F+  +   + K RP A +LL+  F+
Sbjct:  365 GKLLGQGAFGRVFLCYDADTGRELAVKQVQFDP-DSPETSKEVSALECEIQLLKNLFHERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGI--KSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPPWAEFEA-MAAIFKIATQPTNPTLPPHVSDHCRDFLKRIFV-ETKQRPAAEDLLRHTFV 622
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k15 (mitogen-activated protein kinase kinase kinase 15 [Source:ZFIN;Acc:ZDB-GENE-091204-246])

HSP 1 Score: 175.252 bits (443), Expect = 9.635e-46
Identity = 104/264 (39.39%), Postives = 154/264 (58.33%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFI-----NYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKI-SRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEK-KLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ*IE 1679
            +G G +G V+  +        AIK I      Y++    +I L+       LK+  IVQY G++  +  + IFME +P GSL+  + S+   +K   +I Y+RQILEG+ +LH  +I+HRD+K  N+L++  + + K++DFG S+   R  G++  T++F GT  + APEI+   P  Y  PADIWSLG TII M T +PP+H+L  P A +FK+G  K   E+P  +S E + FIL   +PDP  R  A +LLK  FL Q I+
Sbjct:  471 LGRGTYGVVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALH-----KYLKHRNIVQYLGSVSEDGYIKIFMEQVPGGSLSALLRSKWGPLKEATIIFYTRQILEGIRYLHENQIVHRDIKGDNVLVNTYSGVLKISDFGTSK---RLAGVNPCTETFTGTLQYMAPEIIDKGPRGYGAPADIWSLGCTIIEMATGKPPFHELGEPQAAMFKVGMFKIHPEIPESLSSEAKSFILSSFEPDPNKRAMAGDLLKDPFLRQNIK 726
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 183.341 bits (464), Expect = 1.613e-49
Identity = 101/263 (38.40%), Postives = 151/263 (57.41%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAI--KTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L + RIVQY+G++  K E  L IFME++P GS+ D++    ++  +   RY+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LP + SE+ R F+  +L  + + RPTA EL++  F
Sbjct:  365 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQ-LLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPPNTSEQCRDFVKRIL-VEARQRPTAEELIRHPF 624
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 182.956 bits (463), Expect = 1.684e-49
Identity = 101/263 (38.40%), Postives = 151/263 (57.41%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAI--KTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L + RIVQY+G++  K E  L IFME++P GS+ D++    ++  +   RY+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LP + SE+ R F+  +L  + + RPTA EL++  F
Sbjct:  347 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQ-LLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPPNTSEQCRDFVKRILV-EARQRPTAEELIRHPF 606
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 181.415 bits (459), Expect = 7.902e-49
Identity = 106/301 (35.22%), Postives = 168/301 (55.81%), Query Frame = 3 
Query:  801 EARQLRQQISAMGLQ---CNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSF------LPMLKNARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            E R+ R   S  G       SQ  +   P++ E+ +   G+ +G GAFG V+ C      R  A+K + +   D ++    +N+       L + ++ RIVQY+G ++  TE +L IF+E++P GS+ D++    ++  +   RY+RQIL+G+ +LHG  I+HRD+K  NIL D   N+KL DFG S+ +          KS  GTP + +PE++SG+ Y   AD+WS+  T++ M+T +PP+ + E   A IFKI  +  K  LP  +S+  R F+  +   + K RPTA ELL+  F+S
Sbjct:  320 EQRKKRWNSSEQGFPFFCSTSQEQNNKSPQAPENWRL--GKLLGRGAFGEVYLCYDVDKGRELAVKQVPFDP-DSQETSKEVNALECEIQLLKLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWSEYEA-MAAIFKIATQPTKPRLPDTVSDACRDFMKQIFV-EEKRRPTAEELLRHLFVS 615
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 181.415 bits (459), Expect = 8.703e-49
Identity = 106/301 (35.22%), Postives = 168/301 (55.81%), Query Frame = 3 
Query:  801 EARQLRQQISAMGLQ---CNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSF------LPMLKNARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            E R+ R   S  G       SQ  +   P++ E+ +   G+ +G GAFG V+ C      R  A+K + +   D ++    +N+       L + ++ RIVQY+G ++  TE +L IF+E++P GS+ D++    ++  +   RY+RQIL+G+ +LHG  I+HRD+K  NIL D   N+KL DFG S+ +          KS  GTP + +PE++SG+ Y   AD+WS+  T++ M+T +PP+ + E   A IFKI  +  K  LP  +S+  R F+  +   + K RPTA ELL+  F+S
Sbjct:  327 EQRKKRWNSSEQGFPFFCSTSQEQNNKSPQAPENWRL--GKLLGRGAFGEVYLCYDVDKGRELAVKQVPFDP-DSQETSKEVNALECEIQLLKLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWSEYEA-MAAIFKIATQPTKPRLPDTVSDACRDFMKQIFV-EEKRRPTAEELLRHLFVS 622
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 175.637 bits (444), Expect = 6.758e-47
Identity = 100/262 (38.17%), Postives = 153/262 (58.40%), Query Frame = 3 
Query:  909 GEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELN--INSF---LPMLKN---ARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            G+ +G GAFG V+ C  +   R  A+K +   +FD   +E +  +N+    + +LKN    RIVQY+G ++   E  L IFME++P GS+ D++    ++      +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          KS  GTP + +PE++SG+ Y   ADIWS+G T++ M+T +PP+ + E   A IFKI  +    +LP+ +SE  R F+  +   + K RP++ ELL+  F
Sbjct:  342 GKLLGQGAFGRVYLCYDADTGRELAVKQV---QFDPDSLETSKEVNALECEIQLLKNLLHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEA-MAAIFKIATQPTNPQLPAHVSEHCRDFLKRIFV-EAKVRPSSEELLRHTF 598
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874])

HSP 1 Score: 179.874 bits (455), Expect = 1.793e-48
Identity = 103/265 (38.87%), Postives = 152/265 (57.36%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLL--IRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L++ RIVQY+G ++  +E  L IFME++P GS+ D++    ++      +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L  I   G  I  +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F+  +   + + RP+A ELL   F
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQ-LLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGI--RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 621
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k15 (mitogen-activated protein kinase kinase kinase 15 [Source:MGI Symbol;Acc:MGI:2448588])

HSP 1 Score: 177.948 bits (450), Expect = 1.500e-46
Identity = 107/264 (40.53%), Postives = 161/264 (60.98%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDI--------ELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKI-SRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEK-KLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            +G G++G V+    +G D S  ++ I   +  +RDI        E+ ++ +L   K+  IVQY G++     + IFME +P GSL+  + S+   +K   +  Y++QILEGL++LH  +I+HRD+K  N+L++  + + K++DFG S+   R  GI+  T++F GT  + APEI+   P  Y  PADIWSLG TII M TS+PP+H+L  P A +FK+G  K   E+P  +S E R FIL   +PDP+ R TAA+LL+  FL Q
Sbjct:  662 LGKGSYGIVY----AGRDLSNQVR-IAIKEIPERDIRYSQPLHEEIALHKYL---KHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSK---RLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQEGFLRQ 914
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873])

HSP 1 Score: 169.474 bits (428), Expect = 8.024e-45
Identity = 97/261 (37.16%), Postives = 149/261 (57.09%), Query Frame = 3 
Query:  909 GEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSF---LPMLKN---ARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            G+ +G GAFG V+ C      R  A+K + +   +  +    +N+    + +LKN    RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   NIKL DFG S+ L          KS  GTP + +PE++SG+ Y   ADIWS+  T++ M+T +PP+ + E   A IFKI  +    +LP  +S+  R F+  +   + K RP+A ELL+  F+
Sbjct:  359 GKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNP-ESPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEA-MAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFV-EAKLRPSAEELLRHMFV 616
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k6 (mitogen-activated protein kinase kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1855691])

HSP 1 Score: 157.147 bits (396), Expect = 1.274e-39
Identity = 95/261 (36.40%), Postives = 147/261 (56.32%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNIN-----SFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDN---VIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEK-KLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            +G G +G V+    +G DR   ++ I   +  +RD   +       +    L++  IV+Y G+      L IFME +P GSL+  +        DN   +  Y+RQIL+GL +LH  +I+HRD+K  N+L++  + + K++DFG S+   R  GI+  T++F GT  + APEI+   P  Y   ADIWSLG T+I M T +PP+H+L +P A +F++G  K    +P  +S E + F+L   +PDP+ R +A ELL   FL
Sbjct:  655 LGRGTYGVVY----AGRDRHTRVR-IAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSK---RLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFL 907
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k5 (mitogen-activated protein kinase kinase kinase 5 [Source:MGI Symbol;Acc:MGI:1346876])

HSP 1 Score: 155.992 bits (393), Expect = 2.743e-39
Identity = 99/261 (37.93%), Postives = 148/261 (56.70%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFI-----NYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDN---VIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEK-KLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            +G G +G V+  +        AIK I      Y++    +I L+ +     LK+  IVQY G+      + IFME +P GSL+  +  +     DN   +  Y++QILEGL++LH  +I+HRD+K  N+L++  + + K++DFG S+   R  GI+  T++F GT  + APEI+   P  Y   ADIWSLG TII M T +PP+++L  P A +FK+G  K   E+P  +S E + FIL   +PDP  R  A +LL  +FL
Sbjct:  693 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKH-----LKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSK---RLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFL 945
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q99759|M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2)

HSP 1 Score: 179.874 bits (455), Expect = 1.242e-47
Identity = 100/263 (38.02%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L++ RIVQY+G ++  +E  L IFME++P GS+ D++    ++      +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F+  +   + + RP+A ELL   F
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQ-LLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 621
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q61084|M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus OX=10090 GN=Map3k3 PE=1 SV=1)

HSP 1 Score: 179.874 bits (455), Expect = 1.254e-47
Identity = 103/265 (38.87%), Postives = 152/265 (57.36%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLL--IRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L++ RIVQY+G ++  +E  L IFME++P GS+ D++    ++      +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L  I   G  I  +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +    +LPS ISE  R F+  +   + + RP+A ELL   F
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQ-LLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGI--RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 621
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|A2AQW0|M3K15_MOUSE (Mitogen-activated protein kinase kinase kinase 15 OS=Mus musculus OX=10090 GN=Map3k15 PE=1 SV=1)

HSP 1 Score: 177.948 bits (450), Expect = 1.049e-45
Identity = 107/264 (40.53%), Postives = 161/264 (60.98%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDI--------ELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKI-SRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEK-KLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            +G G++G V+    +G D S  ++ I   +  +RDI        E+ ++ +L   K+  IVQY G++     + IFME +P GSL+  + S+   +K   +  Y++QILEGL++LH  +I+HRD+K  N+L++  + + K++DFG S+   R  GI+  T++F GT  + APEI+   P  Y  PADIWSLG TII M TS+PP+H+L  P A +FK+G  K   E+P  +S E R FIL   +PDP+ R TAA+LL+  FL Q
Sbjct:  662 LGKGSYGIVY----AGRDLSNQVR-IAIKEIPERDIRYSQPLHEEIALHKYL---KHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSK---RLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQEGFLRQ 914
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q6ZN16|M3K15_HUMAN (Mitogen-activated protein kinase kinase kinase 15 OS=Homo sapiens OX=9606 GN=MAP3K15 PE=1 SV=2)

HSP 1 Score: 176.407 bits (446), Expect = 2.977e-45
Identity = 105/261 (40.23%), Postives = 153/261 (58.62%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFI-----NYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKI-SRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEK-KLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            +G G +G V+  +        AIK I      Y++    +I L+       LK+  IVQY G++     + IFME +P GSL+  + S+   +K   +  Y++QILEGL++LH  +I+HRD+K  N+L++  + + K++DFG S+   R  G++  T++F GT  + APEI+   P  Y  PADIWSLG TII M TS+PP+H+L  P A +FK+G  K   E+P  +S E R FIL   +PDP  R T AELL+  FL Q
Sbjct:  658 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALH-----KYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSK---RLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQ 910
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q9Y2U5|M3K2_HUMAN (Mitogen-activated protein kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP3K2 PE=1 SV=2)

HSP 1 Score: 170.244 bits (430), Expect = 3.187e-44
Identity = 97/261 (37.16%), Postives = 149/261 (57.09%), Query Frame = 3 
Query:  909 GEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSF---LPMLKN---ARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            G+ +G GAFG V+ C      R  A+K + +   D  +    +N+    + +LKN    RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          KS  GTP + +PE++SG+ Y   ADIWS+  T++ M+T +PP+ + E   A IFKI  +    +LP  +S+  R F+  +   + K RP+A ELL+  F+
Sbjct:  359 GKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDP-DSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEA-MAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFV 616
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A0H3YJG2 (Slc42a-1 OS=Schmidtea mediterranea OX=79327 GN=slc42a-1 PE=2 SV=1)

HSP 1 Score: 254.988 bits (650), Expect = 2.371e-70
Identity = 150/406 (36.95%), Postives = 231/406 (56.90%), Query Frame = 3 
Query:  447 PVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNLSPMVIAERNKDLINMLNAGVEARQLRQQISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFA---GTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLE--LPSDISEEMRIFILDLLQPDPKDRPTAAELL 1649
            P+  AC  GH  I+++ I QKCN+++      R +H A      +I+K+LI++   + +     + PIH AC  + +E  Q+L+++NCD+        SP+ IAE   D  NM+    E + +R+  + M L+C   C+HK C  S + KK    + I  G++GTVF    SG DR FA+K I       R IE NIN F  +L + RIV++FGA   +    IFME+L   +L  K  +++S  P +++ +++QILE L FLH + IIHRD+KP N+L+D + N+KL+DFG+S LL     ++ D +      GT  + APEI++ + Y    DIWSLGAT+I + T QPPYH+L    A+I  I   +++E  LP  + + +   I  +L+ D   R +A +LL
Sbjct:  542 PILYACKYGHRKIVKYFIKQKCNVDSFDCEFRRALHYAVISNNNDIVKLLIESGAAINVPDSLLMMPIHLACKVNNIEAAQLLMENNCDMVTLDKLKRSPLQIAETG-DFENMIKLIKECQIIREIAAEMQLKCGKLCNHKFCYTSFQRKKIKNRKCIASGSYGTVFLYNESGTDRKFAVKKIPKQNIRARYIEANINDFKNLLCHERIVKHFGAFHKKENHYIFMEYLD--TLQKKKYQKKS--PGDLLLFAKQILEALSFLHERSIIHRDIKPENVLLDIDGNLKLSDFGLSLLL---SSVAEDIQKEGRCCGTYCYAAPEILNAELYTCSVDIWSLGATMIQLCTGQPPYHNL-GDGAIITVISTTREIEYKLPEYMPKYISNLIDHMLEKDQYKRLSAKKLL 938

HSP 2 Score: 67.781 bits (164), Expect = 5.627e-8
Identity = 44/175 (25.14%), Postives = 85/175 (48.57%), Query Frame = 3 
Query:  132 SSIDEFELFIDAVERNSAKSFSEYFKSEYLNSK-DKNSMLPIHIACYEGHTQMVQMLISKKCDLEACTKYNC---RPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLR 644
            S  ++F   I A++  S +   +Y+    L  K    S  PI  AC  GH ++V+  I +KC++++   ++C   R +H+A    + DI+K+L+     I+  +     P+HLAC   +    Q L++  C++ T       P+ +A       ++K++ + +   EI A+  L+
Sbjct:  502 SEFEKFGQLIKAIKDGSIEDVKKYYSRRILEIKLGSYSRSPILYACKYGHRKIVKYFIKQKCNVDS---FDCEFRRALHYAVISNNNDIVKLLIESGAAINVPDSLLMMPIHLACKVNNIEAAQLLMENNCDMVTLDKLKRSPLQIAETGDFENMIKLIKECQIIREIAAEMQLK 673
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A7S4G7 (Predicted protein (Fragment) OS=Nematostella vectensis OX=45351 GN=v1g104385 PE=4 SV=1)

HSP 1 Score: 191.045 bits (484), Expect = 1.329e-52
Identity = 104/263 (39.54%), Postives = 161/263 (61.22%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFI------NYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            + +G+ +G GAFG V+ C      R  A+K I      + TK + + +E  I  F+   +N RIVQY+G    +  + IFME+LP GS+++ I +  ++      +YSRQILEG+ +LH  +I+HRD+K  NIL D   N+KLADFG S+ L +T       +S  GTP + APE+++G+ Y   AD+WS+G T++ M+T++PP+ D E P A +FKI  +  + ELPSD+S +   F+   L+ + K RP+A ELL+  F++
Sbjct:    4 WRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEIE-FMKAFRNERIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRL-QTIRSKTGFRSVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFE-PMAALFKIATQPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADELLRFSFVT 263
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A267FTA2 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig024460g1 PE=4 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 1.864e-49
Identity = 104/266 (39.10%), Postives = 159/266 (59.77%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY-------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLE--LPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            + +G+ +G GAFG V+ C      R FA+K +         T  + + +E+ I + L    + RIVQY G  +    LCIFME++  GSL D+I R   I+     +Y+R +LEGL FLH   I+HRD+K  NIL D + N+KL+DFG ++  I+T   ++ TK FAGT  + APE++ G  Y+  ADIWSLG+T++  +T  PPYH LE   +VI++I +++K++  LPS+++E  R FI        + RP A  LL+ +F ++
Sbjct:  268 WKQGDLLGQGAFGKVYKCHDQDSGRLFAMKVVQLDANQDPATSREVKALEIEIQT-LKKFSHERIVQYLGYHQDAYRLCIFMEYMDCGSLRDEIKRFGPIREILARKYTRMVLEGLSFLHRNTIVHRDIKGANILKDSQGNVKLSDFGSAK-HIKTLQSAMSTK-FAGTAPYIAPEVIRGKKYHYKADIWSLGSTVVEFLTGHPPYHQLENAVSVIYRIVSDQKVDYTLPSEVTETARQFIDACFTHALEQRPDADSLLRHRFCTE 530
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A210PFZ5 (Mitogen-activated protein kinase kinase kinase 2 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT24565 PE=4 SV=1)

HSP 1 Score: 186.422 bits (472), Expect = 2.402e-49
Identity = 102/264 (38.64%), Postives = 158/264 (59.85%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDK------RDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKK--LELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            + +G  +G G+FG VF C      R  A+K +N  + +       R +E  I   L   ++ RIV YFG  +  S L IFME++P GS+ D++++   +      +Y+RQ+LEGL FLH   I+HRD+K  N+L D + NIKLADFG S+ L  T   +   KSF GTP++ APE+++G+ Y   AD+WSLG T++ MI+ +PP+ +LE+  A I+KI   ++   ELP   SE  R F+    + +P +RP++ +LL+ +F +
Sbjct:  130 WKKGHRLGSGSFGEVFVCYDKDSGRELAVKQVNLNQMNAETSKEVRALENEIQ-LLRNFQHERIVSYFGCHQDHSILSIFMEYMPGGSIKDELAKYGPLTEGVTRKYTRQMLEGLAFLHKNVIVHRDIKAANVLRDLQGNIKLADFGASKRL-HTICSATGFKSFVGTPHYMAPEVINGEGYGRKADVWSLGCTVVEMISGKPPWSELES-MAAIYKIATAERPEFELPQRSSEFSREFLRLTFRRNPLERPSSEDLLRHRFTA 390
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A1I8I3V2 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011660g3 PE=4 SV=1)

HSP 1 Score: 189.119 bits (479), Expect = 4.726e-49
Identity = 103/266 (38.72%), Postives = 159/266 (59.77%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY-------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLE--LPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            + +G+ +G GAFG V+ C      R FA+K +         T  + + +E+ I + L    + RIVQY G  +    LCIFME++  GSL D+I R   I+     +Y+R +LEGL FLH   I+HRD+K  NIL D + N+KL+DFG ++  I+T   ++ T +FAGT  + APE++ G  Y+  ADIWSLG+T++  +T  PPYH LE   +VI++I +++K++  LPS+++E  R FI        + RP A  LL+ +F ++
Sbjct:  268 WKQGDLLGQGAFGKVYKCHDQDSGRLFAMKVVQLDANQDPATSREVKALEIEIQT-LKKFSHERIVQYLGYHQDAYRLCIFMEYMDCGSLRDEIKRFGPIREILARKYTRMVLEGLSFLHRNTIVHRDIKGANILKDSQGNVKLSDFGSAK-HIKTLQSAMST-TFAGTAPYIAPEVIRGKKYHYKADIWSLGSTVVEFLTGHPPYHQLENAVSVIYRIVSDQKVDYTLPSEVTETARQFIDACFTHALEQRPDADSLLRHRFCTE 530
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 184.882 bits (468), Expect = 2.573e-50
Identity = 103/263 (39.16%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLE-LPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L + RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L      S   +S  GTP + +PE++SGD Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +     LPS  SE+ R FI  +   + K RP+A ELL+  F
Sbjct:  356 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQ-LLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPILPSHTSEQTRDFIRRIFV-EAKHRPSAEELLRHPF 615
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 184.882 bits (468), Expect = 2.573e-50
Identity = 103/263 (39.16%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLE-LPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L + RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L      S   +S  GTP + +PE++SGD Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +     LPS  SE+ R FI  +   + K RP+A ELL+  F
Sbjct:  356 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQ-LLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPILPSHTSEQTRDFIRRIFV-EAKHRPSAEELLRHPF 615
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 184.882 bits (468), Expect = 2.573e-50
Identity = 103/263 (39.16%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLE-LPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L + RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L      S   +S  GTP + +PE++SGD Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +     LPS  SE+ R FI  +   + K RP+A ELL+  F
Sbjct:  356 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQ-LLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPILPSHTSEQTRDFIRRIFV-EAKHRPSAEELLRHPF 615
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:103026704])

HSP 1 Score: 172.17 bits (435), Expect = 7.081e-46
Identity = 102/263 (38.78%), Postives = 153/263 (58.17%), Query Frame = 3 
Query:  909 GEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSF---LPMLKN---ARIVQYFGAIKT--ESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLL--IRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            G+ +G GAFG VF C  +   R  A+K + +   D  +    +++    + +LKN    RIVQY+G ++   E  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG SR L  I   G  I  KS  GTP + +PE++SG+ Y   ADIWS+G T++ M+T +PP+ + E   A IFKI  +     LP+ +S+  R F+  +   + K RP A ELL+  F+
Sbjct:  362 GKLLGQGAFGRVFLCYDADTGRELAVKQVQFDP-DSPETSKEVSALECEIQLLKNLFHERIVQYYGCLRDTHERTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGI--KSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTLRPPWAEFEA-MAAIFKIATQPTNPALPAHVSDHCRDFLKRIFV-ETKQRPAAEELLRHIFV 619
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k15 (mitogen-activated protein kinase kinase kinase 15 [Source:ZFIN;Acc:ZDB-GENE-091204-246])

HSP 1 Score: 174.481 bits (441), Expect = 1.570e-45
Identity = 103/259 (39.77%), Postives = 151/259 (58.30%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFI-----NYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKI-SRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEK-KLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            +G G +G V+  +        AIK I      Y++    +I L+       LK   IVQY G++  +  + IFME +P GSL+  + S+   +K   +I Y+RQILEGL +LH  +I+HRD+K  N+L++  + + K++DFG S+   R  G++  T++F GT  + APEI+   P  Y  PADIWSLG TII M T +PP+H+L  P A +FK+G  K   E+P  +S E + FIL   +PDP  R TA +LLK  F+
Sbjct:  647 LGRGTYGVVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALH-----KYLKQRNIVQYLGSVSEDGYIKIFMEQVPGGSLSALLRSKWGPLKEATIIFYTRQILEGLRYLHENQIVHRDIKGDNVLVNTYSGVLKISDFGTSK---RLAGVNPCTETFTGTLQYMAPEIIDKGPRGYGAPADIWSLGCTIIEMATGKPPFHELGEPQAAMFKVGMFKIHPEIPESLSTEAKSFILRCFEPDPNKRATAGDLLKDLFV 897
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 177.948 bits (450), Expect = 1.391e-48
Identity = 99/266 (37.22%), Postives = 153/266 (57.52%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELN--INSF------LPMLKNARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKK-LELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            + RG+ +G GAFG V+ C  +   R  A+K +   +FD   +E +  +N+       L  L++ RIVQYFG ++   +  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ FLHG  I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE+++G+ Y   ADIWS+G T++ M+T +PP+ + E   A IFKI  +     LP   SE  R  +  +   + K RP+A +LL+  F+
Sbjct:  359 WQRGKLLGQGAFGRVYLCYDADTGRELAVKQV---QFDPGSVETSKEVNALECEIQLLKNLQHERIVQYFGCLRDPQQKTLSIFMEYMPGGSIKDQLRAYGALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGTAMRSVTGTPYWMSPEVINGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEA-MAAIFKIATQPTDPRLPLHASEHARDLLRRIFV-EAKLRPSAEDLLRHPFV 619
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92])

HSP 1 Score: 140.584 bits (353), Expect = 1.564e-36
Identity = 92/279 (32.97%), Postives = 147/279 (52.69%), Query Frame = 3 
Query:  852 SQCDHKLCPKSL---ESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNIN-SFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLK--PGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            ++C H   P++      + F + E IG G+FG VF    +      AIK I+  + +    ++    + L    +  +  YFG+    ++L I ME+L  GS  D I +   ++   +    R+IL+GL++LH ++ IHRD+K    N+L+ ++ ++KLADFG++  L  T    I   +F GTP + APE++    Y+  ADIWSLG T I +   +PP  +L  P  V+F I       L  + S+  + F+   L  DP+ RPTA ELLK KF+ +
Sbjct:    7 TRCPHPRPPQNSCADPEELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALDLI-KPGPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDT---QIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSELH-PMRVLFLIPKNNPPTLEGNYSKAFKEFVDSCLNKDPQFRPTAKELLKHKFIQR 280
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66])

HSP 1 Score: 142.124 bits (357), Expect = 1.269e-35
Identity = 98/266 (36.84%), Postives = 141/266 (53.01%), Query Frame = 3 
Query:  915 EIGHGAFGTVFHC--KGSGI-DRSFAIKFINYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLND-KISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGIS----RLLIRTDGISIDTKSFAGTPNFTAPEI-----MSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEK--KLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            E+G GAFG V+    K SG+   +  I+  +  + +   +E+ I   L +  +  IV    A   E++L IF+EF P G+++   +  ER +    +    +Q+LE L +LH  +IIHRDLK GNIL+  E ++KLADFG+S    R L R D       SF GTP + APE+     M   PY+  ADIWSLG T+I +   +PP H+L  P  V+ KI       L  PS  S E   F+   L  +P+ R  A +LL+  F+S
Sbjct:   38 ELGDGAFGKVYKAQNKESGVLAAAKVIETKSEEELEDYMVEIEI---LALCDHPNIVGLLNAFYYENKLWIFIEFCPGGAVDAIMLELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVSAKNTRTLQRRD-------SFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPNHEL-NPMRVMLKIAKNDPPSLSFPSKWSAEFTDFLKKCLDKNPETRWNALQLLQHSFIS 292
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008193.1 (pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-1 gene:ENSPMAG00000007385.1 transcript:ENSPMAT00000008193.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 125.561 bits (314), Expect = 1.040e-31
Identity = 77/245 (31.43%), Postives = 129/245 (52.65%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIG-NEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELL 1649
            +G GA G VF  K  G     A+K +   K      E +I   L  L++  I+ + G        CI ME+   G L + +   R I P+ ++ ++R I  G+ +LH  KIIHRDLK  N+L+  ++ +K++DFG S+ + R     +   SFAGT  + APE++  +P +   DIWS G  +  ++T + PY D+++  A+I+ +G N   L +P+   E  +I +       P++RP+  ++L
Sbjct:   20 LGSGAQGAVFLGKFRG--EHVAVKKVREQK------ETDIK-HLHKLRHPNIITFKGVCTHAPCYCIIMEYCAQGQLYEVLRAGRRISPELLVGWTRGIARGMSYLHLHKIIHRDLKSPNVLITHDDEVKISDFGTSKEM-REKSTRM---SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYRDVDSS-AIIWGVGSNSLHLPIPASCPEGFKILLTQCWNSKPRNRPSFRQIL 250
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002962.1 (pep scaffold:Pmarinus_7.0:GL476671:16080:33623:-1 gene:ENSPMAG00000002691.1 transcript:ENSPMAT00000002962.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 128.257 bits (321), Expect = 3.995e-31
Identity = 82/257 (31.91%), Postives = 130/257 (50.58%), Query Frame = 3 
Query:  915 EIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNI---NSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKIS-RERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEI---MSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            EIGHG+FG V+  +        AIK ++Y+     +   +I     FL  LK+  I++Y G    E    + ME+  LGS +D +   ++ ++   +   +   L+GL FLH   +IHRD+K GNIL+ +   +KLADFG       +  ++    SF GTP + APE+   M    Y+   D+WSLG T I +   +PP  ++    A+     N+       + S+  R F+   LQ + +DRPT+A LL+  F+
Sbjct:   35 EIGHGSFGAVYFARNIHTSEVVAIKKMSYSGKQSNEKWQDIIKEVKFLTKLKHPNIIEYKGCYLREHTAWMIMEYC-LGSASDLLEVHKKPLQEIEIAAIAHGALQGLAFLHNHTMIHRDVKAGNILLTEPGQVKLADFG-------SASLTAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSPEWSDYFRNFVDSCLQKNGQDRPTSAGLLRHAFV 283
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 156.377 bits (394), Expect = 1.617e-40
Identity = 98/262 (37.40%), Postives = 148/262 (56.49%), Query Frame = 3 
Query:  882 SLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELN-INSFLPMLKNAR---IVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIR-YSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLK 1652
            S +S ++H  + IG G++G V+       D+  AIK + Y    + D ELN I + + +LKN     IV+Y G I+   EL I +E+   GSL   ISR  +   +N  + Y  Q L GL++LHG+ +IHRD+K  NIL+  +N +KLADFG+S +      ++    + AGT N+ APEI+     +  +DIWSLGAT++ M+T  PPYH+L T   + + + N+     PS  SE ++ F+      +   RPTA +LLK
Sbjct:   19 SEKSVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVY----ENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTI------VNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNL-TDANIYYAVENDTYYP-PSSFSEPLKDFLSKCFVKNMYKRPTADQLLK 268
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 140.584 bits (353), Expect = 2.677e-35
Identity = 94/273 (34.43%), Postives = 148/273 (54.21%), Query Frame = 3 
Query:  864 HKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPM--LKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE--KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            +++C     S K+    +IG GA G V+     G + S AIK +N  K  K+  EL IN  L M   K+  IV +  +   + +L + ME++  GSL D ++    +    +    R+ L GLEFLH K ++HRD+K  NIL+  E +IKL DFG      + + +++   +  GTP + APE++S   Y    DIWSLG  II MI  +PPY + ETP   ++ I      KL+ P ++S  ++ F+   L  +P+DR +A ELL  +++++
Sbjct:  608 NEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKK--ELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTH-CILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFG---FCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLN-ETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITE 873
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 133.65 bits (335), Expect = 4.352e-33
Identity = 95/262 (36.26%), Postives = 140/262 (53.44%), Query Frame = 3 
Query:  891 SKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY-TKFDK-RDIELNINSFLPMLKN-ARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPE-IMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            S  F R E IG G FG V+        R +AIK +N  +  D+  D++  I  FL  LK  + I +Y+G+   ++ L I ME    GSL   + R   I    +    R++L  L+ +H   +IHRD+K  N+L+ +E N+KL DFG++  + +T   S+  ++ AGTP + APE IM G  Y+   DIWSLG T   + T  PPY D+E   A+   I ++         S  ++ FI   L  DPK+R +A +LLKSKF+
Sbjct:   20 SSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQ-FLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLL-RPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQT---SLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFI 276
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 129.798 bits (325), Expect = 5.793e-32
Identity = 73/208 (35.10%), Postives = 114/208 (54.81%), Query Frame = 3 
Query: 1041 SFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            + L  L +  IV Y+GA +    L IF+E++P GS++  ++     +   +  ++RQIL G+ +LH K IIHRD+K  NIL+D +  +K+ DFGIS+ L   +       S  G+  + +PE++        ADIWS G  +I M T + P+ D     A IFKIG     E+PS  + E + F+    + D + RP+A ELL+  +L
Sbjct:  506 NLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQA-IFKIGTNTTPEIPSWATSEGKNFLRKAFELDYQYRPSALELLQHPWL 712
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: SSK22 (MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication [Source:SGD;Acc:S000000669])

HSP 1 Score: 126.716 bits (317), Expect = 8.640e-31
Identity = 92/289 (31.83%), Postives = 146/289 (50.52%), Query Frame = 3 
Query:  891 SKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY--TKFDKRDIEL--NINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIR-YSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLI--RTDGI--------SIDTKSF---AGTPNFTAPEIMSGDPYNVPA---DIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPS--DISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ*IEIIY 1688
            S ++ +   IG G FG V+           A+K I    T   K+   L     + L ML +  IVQY+G      ++ IFME+   GSL   +   R I+ + V + Y+ ++LEGL +LH   ++HRD+KP NIL+D    IK  DFG +R ++  RT  +         ++TKS     GTP + APE +SG          D+W+LG  ++ M T + P+ +L+  WA+++ +   +  +LP+  +++   R F+   L  DP  R TA ELL   ++ Q  EI +
Sbjct: 1031 SMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGR-IEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWMIQIREIAF 1318
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7])

HSP 1 Score: 191.815 bits (486), Expect = 1.277e-56
Identity = 104/263 (39.54%), Postives = 161/263 (61.22%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFI------NYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            + +G+ +G GAFG V+ C      R  A+K I      + TK + + +E  I  F+   +N RIVQY+G    +  + IFME+LP GS+++ I +  ++      +YSRQILEG+ +LH  +I+HRD+K  NIL D   N+KLADFG S+ L +T       +S  GTP + APE+++G+ Y   AD+WS+G T++ M+T++PP+ D E P A +FKI  +  + ELPSD+S +   F+   L+ + K RP+A ELL+  F++
Sbjct:    4 WRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEIE-FMKAFRNERIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRL-QTIRSKTGFRSVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFE-PMAALFKIATQPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADELLRFSFVT 263
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4])

HSP 1 Score: 145.206 bits (365), Expect = 2.957e-38
Identity = 91/258 (35.27%), Postives = 143/258 (55.43%), Query Frame = 3 
Query:  894 KKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNIN-SFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            K F + E IG G+FG VF    +  +   AIK I+  + +    ++    + L    +  + +Y G+    ++L I ME+L  GS  D + +  +I+   +    R++L+GL++LH +K +HRD+K  N+LM +  ++KLADFG++  L  TD ++    +F GTP + APE++    Y+  ADIWSLG T I +   +PP  DL  P  V+F I      EL  + S+  + F+   L  DP DRPTA ELLK +F+
Sbjct:    9 KLFSKLERIGKGSFGEVFKGIDNRTNEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSLYVTKYHGSYLKGTKLWIIMEYLGGGSALD-LMKAGNIEEFYIATILREVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQL--TDTLN-KRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPNSDLH-PMRVLFLIPKNNPPELTGNFSKAFKEFVSLCLNKDPNDRPTAKELLKHRFI 261
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO47821 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL88])

HSP 1 Score: 139.043 bits (349), Expect = 3.601e-37
Identity = 92/277 (33.21%), Postives = 141/277 (50.90%), Query Frame = 3 
Query:  888 ESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY---------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDT----KSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKL-ELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            E  ++ +G  +G GAFGTVF           A+K +            +++K   E+ +   L  LK+  IVQY G    +S+  + IFMEF+P GS+   + R  +       RY+RQIL+G+ +LH   +IHRD+K GNI++     IKL DFG ++ +    G  +      +S  GTP + APE++    +   +DIWS+G T+  M T QPP+ ++  P + IF IGN   +  L    S     F+   +  D   RP+A ELL+  FL +
Sbjct:    1 EEIEWQKGNVLGKGAFGTVF-LGLVNTGELIAVKQVELHPNNVDAAERQYEKLQEEVGL---LKSLKHKNIVQYIGTCMDDSQCTINIFMEFVPGGSIAQALKRFGAFVEPVFRRYTRQILDGVSYLHNNNVIHRDIKGGNIMLMPNGVIKLIDFGCAKKICMV-GAHVSKSNILRSMRGTPYWMAPEVIRETGHGRKSDIWSIGCTVFEMATGQPPWSNV-PPLSAIFAIGNGSPVPRLDESFSAAAIDFVTSCMTRDQDTRPSADELLRHDFLQE 271
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO36150 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJF2])

HSP 1 Score: 143.665 bits (361), Expect = 6.499e-36
Identity = 82/272 (30.15%), Postives = 147/272 (54.04%), Query Frame = 3 
Query:  885 LESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIE------LNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDEN-NIKLADFG-ISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPY--HDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            LE+  + +GE +G GAF + +  +        A+K +++ +  K + +      ++  + L  LK+  +++  GA +      IF+E++  GS++  +S+    +   +IRY RQIL+G+ +LH  +++HRD+K  NIL+D    +I++ADFG  +RL  +  G         GT  F APE++ G+ Y    D+WS+G  +I M T +PP+  H+     A+IFKI       ++P  ++  +R  +L  L+  P+DRP A +LL+    +
Sbjct:  572 LENVHWKKGELLGTGAFSSCYGARDVMTGSLMAVKQVSFCRNSKSEQDKVCQTIMDEIAILARLKHPHLIKCLGATRHTGHFNIFLEWMAGGSISMLLSKYGPFEEAILIRYLRQILQGVSYLHENQVVHRDIKGANILVDSTGQDIRIADFGAAARLATQITGAGEFQGQLLGTIAFMAPEVLRGESYGRSCDVWSVGCVLIEMATGKPPWNAHEHSNHLALIFKIACAIGPPDIPEHLNPGVRDVVLRCLESKPEDRPAAVDLLQHPLFT 843
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9])

HSP 1 Score: 135.961 bits (341), Expect = 1.602e-35
Identity = 86/254 (33.86%), Postives = 142/254 (55.91%), Query Frame = 3 
Query:  912 EEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKIS-RERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE--KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            E++G G++G+VF        +  AIK +     D ++I   I S +    +  +V+Y+G+    ++L I ME+   GS++D +  R +++  + +    +  L+GLE+LH ++ IHRD+K GNIL++ E + KLADFG++  L  TD ++    +  GTP + APE++    Y+  ADIWSLG T + M   +PPY D+  P   IF I  +       P   SE+ + F+   L  +P++R TA ELL+  F+
Sbjct:   28 EKLGEGSYGSVFKAMHKESGQVVAIKQVP-VDTDLQEIIKEI-SMMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDLMKIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQL--TDTMA-KRNTVIGTPFWMAPEVIQEVGYDCLADIWSLGITAMEMAEGKPPYADIH-PMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSFI 275
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290])

HSP 1 Score: 178.333 bits (451), Expect = 4.380e-48
Identity = 101/263 (38.40%), Postives = 149/263 (56.65%), Query Frame = 3 
Query:  900 FHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINY------TKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESE--LCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLE-LPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKF 1661
            + RG+ +G GAFG V+ C      R  A K + +      T  +   +E  I   L  L + RIVQY+G ++  SE  L IFME++P GS+ D++    ++  +   +Y+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG S+ L          +S  GTP + +PE++SG+ Y   AD+WSLG T++ M+T +PP+ + E   A IFKI  +     LPS  S++ R FI  +   + K RP+A ELL+  F
Sbjct:  353 WRRGKLLGQGAFGLVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQ-LLKNLHHERIVQYYGCLRDHSEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPLLPSHTSDQARDFIHCIFV-EAKHRPSAEELLRHPF 612
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297])

HSP 1 Score: 173.711 bits (439), Expect = 3.651e-46
Identity = 105/265 (39.62%), Postives = 153/265 (57.74%), Query Frame = 3 
Query:  909 GEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELN-----INSFLPMLKN---ARIVQYFGAIK--TESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLL--IRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            G+ +G GAFG V+ C  +   R  A+K +   +FD    E +     +   + +LKN    RIVQY+G ++   E  L IFME +P GS+ D++    ++  +   RY+RQILEG+ +LH   I+HRD+K  NIL D   N+KL DFG SR L  I   G  I  KS  GTP + +PE++SG+ Y   ADIWS+G T++ M+T +PP+ + E   A IFKI  +    ELP  +S+  R F+  +   + K RP+A ELL+  F+
Sbjct:  392 GKLLGQGAFGRVYLCYDADTGRELAVKQV---QFDPESPETSKEVSALECEIQLLKNLCHERIVQYYGCLRDTMERTLSIFMEHMPGGSIKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSGTGI--KSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTQRPPWAEFEA-MAAIFKIATQPTNPELPVHVSDHCREFLRRIFV-ETKQRPSADELLRHIFV 649
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 169.088 bits (427), Expect = 6.874e-45
Identity = 95/290 (32.76%), Postives = 156/290 (53.79%), Query Frame = 3 
Query:  822 QISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSF------LPMLKNARIVQYFGAIKT--ESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            ++ ++G   +  C             + +G+ +G GAFG V+ C  +   R  A K + +   D ++    +N+       L  L++ RIVQY+G ++   + +L IF+EF+P GS+ D++    ++      RY+RQIL+G+ +LH   I+HRD+K  NIL D   N+KL DFG S+ +          KS  GTP + +PE+++G+ Y   AD+WS+  T++ M+T +PP+ + E   A IFKI  +  K  LP  +S+  R F+  +   + K RPTA  LL   F+
Sbjct:  301 ELRSLGRSADKSCQRGTAKSPRAPVNWRQGKLLGRGAFGEVYLCYDADTGRELAAKQVPFDP-DCQETSKEVNALECEIQLLKNLRHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEA-MAAIFKIATQPTKPTLPEGVSDASRDFLRQVFV-EEKWRPTADILLNHPFV 587
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k15 (mitogen-activated protein kinase kinase kinase 15 [Source:NCBI gene;Acc:101156777])

HSP 1 Score: 172.17 bits (435), Expect = 8.252e-45
Identity = 103/259 (39.77%), Postives = 150/259 (57.92%), Query Frame = 3 
Query:  918 IGHGAFGTVFHCKGSGIDRSFAIKFI-----NYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKI-SRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNI-KLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDP--YNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEK-KLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            +G G +G V+  +        AIK I      Y++    +I L+       LK+  IVQY G+I     + IFME +P GSL+  + S+   +K   +I Y+RQILEGL +LH  +I+HRD+K  N+L++  + + K++DFG S+   R  G++  T++F GT  + APEI+   P  Y  PADIWSLG TII M T +PP+H+L  P A +FK+G  K   E+P  +S E + FIL   +PDP  RP   +LLK  F+
Sbjct:  624 LGRGTYGVVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALH-----KYLKHRNIVQYLGSISENGFIKIFMEQVPGGSLSALLRSKWGPLKEATIIFYTRQILEGLRYLHENQIVHRDIKGDNVLVNTYSGVLKISDFGTSK---RLAGVNPCTETFTGTLQYMAPEIIDKGPRGYGAPADIWSLGCTIIEMATGKPPFHELGEPQAAMFKVGMFKIHPEIPESLSLEAKSFILRCFEPDPNKRPITTDLLKDPFI 874
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 169.088 bits (427), Expect = 8.512e-45
Identity = 98/292 (33.56%), Postives = 159/292 (54.45%), Query Frame = 3 
Query:  822 QISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSF------LPMLKNARIVQYFGAIKT--ESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLL--IRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNE-KKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFL 1664
            ++ ++G   +  C             + +G+ +G GAFG V+ C  +   R  A K + +   D ++    +N+       L  L++ RIVQY+G ++   + +L IF+EF+P GS+ D++    ++      RY+RQIL+G+ +LH   I+HRD+K  NIL D   N+KL DFG S+ +  I   G  I  KS  GTP + +PE+++G+ Y   AD+WS+  T++ M+T +PP+ + E   A IFKI  +  K  LP  +S+  R F+  +   + K RPTA  LL   F+
Sbjct:  331 ELRSLGRSADKSCQRGTAKSPRAPVNWRQGKLLGRGAFGEVYLCYDADTGRELAAKQVPFDP-DCQETSKEVNALECEIQLLKNLRHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGI--KSVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEA-MAAIFKIATQPTKPTLPEGVSDASRDFLRQVFV-EEKWRPTADILLNHPFV 617
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000016834.1 (SMESG000016834.1)

HSP 1 Score: 1053.51 bits (2723), Expect = 0.000e+0
Identity = 509/520 (97.88%), Postives = 514/520 (98.85%), Query Frame = 3 
Query:  111 MNFSDSCSSIDEFELFIDAVERNSAKSFSEYFKSEYLNSKDKNSMLPIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNLSPMVIAERNKDLINMLNAGVEARQLRQQISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            MNFSDSCSSIDEFELFIDAVERNS KSFSEYFKSEYLNSKDKNSMLPIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNLSPMVIAE NKDLINMLNA VEARQLRQQISAMGLQCNSQCDHKLCP SLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFI+YTKFDKR+IELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDN+IRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKS AGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYH+LETP AV+FKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ
Sbjct:    1 MNFSDSCSSIDEFELFIDAVERNSVKSFSEYFKSEYLNSKDKNSMLPIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNLSPMVIAEGNKDLINMLNAAVEARQLRQQISAMGLQCNSQCDHKLCPISLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFISYTKFDKRNIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNIIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSLAGTPNFTAPEIMSGDPYNVPADIWSLGATIINMITSQPPYHNLETPLAVVFKIGNEKKLELPSDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 520
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000017261.1 (SMESG000017261.1)

HSP 1 Score: 501.13 bits (1289), Expect = 5.873e-172
Identity = 263/570 (46.14%), Postives = 354/570 (62.11%), Query Frame = 3 
Query:  141 DEFELFIDAVERNSAKSFSEYFKSEYLNSKDKNSMLPIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLE----------------------------------------------------ICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNLSPMVIA--ERNKDLINMLNAGVEARQLRQQISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIM----SGDPYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELP--SDISEEMRIFILDLLQPDPKDRPTAAELLKSKFLSQ 1670
            +EF+LFI+A++  SA  F  YFK EYL  KD +   PIH AC+ GH ++V++LI   CD+EA  K+N RP+H+AC +GH + +K+L+   C+I + +  + +P+H AC  G +  ++ LI+ KC++E   + N RP+H A   G +E +K+LI+NKCD+E                                                     C     RPIH+AC +  ++V++ LI   CDI A    NLSP+ IA   +NK+L+ +L    +A +L QQI  MGL+C S C+H+LC  SL  K F +G EIG GAFG V+ CKGSGID  FA+K+I   K   + IE NIN FLP L + RI++YFGAI+TE  LCIFME+L  GSL D+I R+RS+  +N+IRYS+QILEGLEFLHG  IIHRD+KP NILM + NNIK+ DFG+SR L+RT G     ++  GTPNFTAPE+      G PY V ADIWSLGAT+INMIT +PPY     P+AV+ KI + KKL+LP    +S+EM+ FI  +L PDP  R TAA+LLK K  S+
Sbjct:    3 EEFKLFINAIKSGSAVLFRRYFKEEYLERKDADLWSPIHHACFAGHAEIVKLLIEHNCDIEALDKWNLRPIHYACYQGHSEAVKLLIEHKCDIEAFDWWNQRPIHYACYQGRSEAVKLLIEHKCDIEAIDEWNQRPIHHACDQGHSEAVKLLIENKCDIEALDESGDSPMEIAVKSHNERIIHILNGPCLLRACKNGDLKKVSTYLNGAAIEYCDKDQRRPIHWACESGNIKVVKSLIKTKCDISARDKSNLSPLDIAIKNQNKELVELL----KAEELEQQILMMGLKCKSFCNHRLCNTSLRKKTFDKGSEIGSGAFGHVYKCKGSGIDTVFAVKWIELKKIGVKCIEENINKFLPKLNHQRIIKYFGAIQTEDHLCIFMEYLSGGSLEDEIKRKRSLATENIIRYSKQILEGLEFLHGNNIIHRDIKPDNILMSNGNNIKITDFGVSRSLLRTCGNVTKAETTIGTPNFTAPEVFLTSDEGPPYTVSADIWSLGATVINMITGRPPYCGCH-PYAVVKKIADTKKLDLPDSQSMSKEMKEFIEKMLDPDPDQRSTAAQLLKLKLFSE 567
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000017274.1 (SMESG000017274.1)

HSP 1 Score: 502.286 bits (1292), Expect = 9.125e-172
Identity = 264/553 (47.74%), Postives = 355/553 (64.20%), Query Frame = 3 
Query:  141 DEFELFIDAVERNSAKSFSEYFKSEYLNSKDKNSMLPIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNL---------------------------------SPMVIAER--NKDLINMLNAGVEARQLRQQ----ISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGD---PYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSD--ISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            +EF+LFI+A++  SA+ F  YFK E+L  KD     PIH AC  GH ++V++LI  KCD+EA    N RP+H AC  GH + +K+L+   C+I + + D+W+P+H AC  GH  I++ LI+ KC++E     N RP+HLA  HG +E +K+LI+NKCD+E   ++  RPIH AC     E +++LI+HNCDIEA   +N                                  SPM  A +  N ++I +LN     RQ +QQ    IS MGL C S CDHKLCP SL  K F +G  IG GAFG ++  +GSGI   FAIK +N    D++ IE NI  FLP L + RIV+YFGAI+TE  LC+FME+ P GSLN +IS + SI+ DNVIRYS+QILEGL+FLHG KIIHRD+KP NIL+D+ENNIKLADFG+ R L+RT G S    +  GT NFTAPE++      PY+  ADIWS+GAT+INMI+ +PPY +  + +AVIFK+   KKL+LP    ++ +++ FI ++L P+PK R +AA+LLK K  S
Sbjct:   70 EEFKLFINAIKSGSAELFRRYFKEEFLERKDAGLRRPIHHACIAGHAEIVKLLIEHKCDIEALDWRNRRPIHLACYHGHSEAVKLLIEHKCDIEALDWDNWRPIHHACIAGHAEIVKLLIEHKCDIEALDWRNRRPIHLACYHGHSEAVKLLIENKCDIEALDEQKRRPIHLACYQGHSEAVKLLIEHNCDIEALDWWNQRPIHHACIQGHSEAVKLLIENKCDIDARDESGNSPMEFAMKSGNTEIIKILNEARLERQRQQQLERQISKMGLTCESGCDHKLCPTSLRDKSFDKGSMIGRGAFGKIYKLQGSGISSVFAIKRMNSEGVDEKYIEGNIYKFLPKLDHQRIVKYFGAIQTEKHLCLFMEYFPRGSLNTEISNKGSIETDNVIRYSKQILEGLKFLHGNKIIHRDIKPDNILLDEENNIKLADFGLGRSLMRTCGKSTRIDTTVGTANFTAPEVLEATDDAPYHESADIWSVGATVINMISGRPPYDNYPS-FAVIFKVMTLKKLDLPKPQLMTAQIKSFIEEMLNPNPKKRSSAAQLLKLKLFS 621
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000017274.1 (SMESG000017274.1)

HSP 1 Score: 502.286 bits (1292), Expect = 1.182e-171
Identity = 265/558 (47.49%), Postives = 357/558 (63.98%), Query Frame = 3 
Query:  126 SCSSIDEFELFIDAVERNSAKSFSEYFKSEYLNSKDKNSMLPIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNL---------------------------------SPMVIAER--NKDLINMLNAGVEARQLRQQ----ISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGD---PYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSD--ISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            S +  +EF+LFI+A++  SA+ F  YFK E+L  KD     PIH AC  GH ++V++LI  KCD+EA    N RP+H AC  GH + +K+L+   C+I + + D+W+P+H AC  GH  I++ LI+ KC++E     N RP+HLA  HG +E +K+LI+NKCD+E   ++  RPIH AC     E +++LI+HNCDIEA   +N                                  SPM  A +  N ++I +LN     RQ +QQ    IS MGL C S CDHKLCP SL  K F +G  IG GAFG ++  +GSGI   FAIK +N    D++ IE NI  FLP L + RIV+YFGAI+TE  LC+FME+ P GSLN +IS + SI+ DNVIRYS+QILEGL+FLHG KIIHRD+KP NIL+D+ENNIKLADFG+ R L+RT G S    +  GT NFTAPE++      PY+  ADIWS+GAT+INMI+ +PPY +  + +AVIFK+   KKL+LP    ++ +++ FI ++L P+PK R +AA+LLK K  S
Sbjct:   70 SLTPCEEFKLFINAIKSGSAELFRRYFKEEFLERKDAGLRRPIHHACIAGHAEIVKLLIEHKCDIEALDWRNRRPIHLACYHGHSEAVKLLIEHKCDIEALDWDNWRPIHHACIAGHAEIVKLLIEHKCDIEALDWRNRRPIHLACYHGHSEAVKLLIENKCDIEALDEQKRRPIHLACYQGHSEAVKLLIEHNCDIEALDWWNQRPIHHACIQGHSEAVKLLIENKCDIDARDESGNSPMEFAMKSGNTEIIKILNEARLERQRQQQLERQISKMGLTCESGCDHKLCPTSLRDKSFDKGSMIGRGAFGKIYKLQGSGISSVFAIKRMNSEGVDEKYIEGNIYKFLPKLDHQRIVKYFGAIQTEKHLCLFMEYFPRGSLNTEISNKGSIETDNVIRYSKQILEGLKFLHGNKIIHRDIKPDNILLDEENNIKLADFGLGRSLMRTCGKSTRIDTTVGTANFTAPEVLEATDDAPYHESADIWSVGATVINMISGRPPYDNYPS-FAVIFKVMTLKKLDLPKPQLMTAQIKSFIEEMLNPNPKKRSSAAQLLKLKLFS 626
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000017084.1 (SMESG000017084.1)

HSP 1 Score: 478.019 bits (1229), Expect = 3.389e-161
Identity = 252/536 (47.01%), Postives = 334/536 (62.31%), Query Frame = 3 
Query:  249 PIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEI--------------------------------CADKNL--------------------RPIHFACANDRVEVLQILIDHNCDIEACADFNLSPMVIAERN--KDLINMLNAGV----EARQLRQQISAMGLQCNSQCDHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKFDKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKISRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKLADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGD---PYNVPADIWSLGATIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSD--ISEEMRIFILDLLQPDPKDRPTAAELLKSKFLS 1667
            PIH+AC +GH++ V++LI  KCD+EA   +N RP+H AC  G+ + +K+L+   C+I + +    +P+HLAC  G +  ++ LID KC++E     N RP+HLA   G +E +K+LID+KC++E                                 C D N+                    RPIH+AC +  +E++++LI  NCDI      N SP  IA +N  K+L+ ++   +    +  +L QQIS M L C S CDHKLCP+SL +K F +G  +G G+FG VF  +GSGID  FAIK I     D + IE NI+ FLP L N RIV+YFGAIKT+  LC+FME+ P GSL  KI  E+SI  DNVIRYS+QILEGLEFLHG KIIHRD+KP NILMD  NNIKLADFG++R L+RT G+S   K+F GT NFT+PE+++ D   PY V +DIWS+GAT+INMI+ + P HD   P  VI KI +EKKLELP    +S EM+ FI ++L PDP  RPTAA+LLK K  S
Sbjct:  171 PIHLACDQGHSEAVKLLIENKCDIEALDIWNQRPIHLACYHGNSEAIKLLIEHKCDIEALDWQKQRPIHLACYQGRSEAVKLLIDHKCDIEALDWLNQRPIHLACDQGYSEAVKLLIDHKCNIEALDGNGDSPLALAEKTGNKGIICILNGARLLLACKDGNVEKVSSLLSDTTIEYYDKDKRRPIHWACESGNIEIVKLLIKTNCDITVRDKSNSSPFDIAVKNDNKELVEIVKCAILDQQQKHELEQQISTMRLTCESGCDHKLCPESLRTKSFDKGSRVGMGSFGEVFKLRGSGIDTDFAIKRIQLEGIDAKYIEGNIHKFLPKLNNIRIVKYFGAIKTKKHLCLFMEYFPQGSLETKILSEKSIATDNVIRYSKQILEGLEFLHGNKIIHRDIKPANILMDQLNNIKLADFGVARSLMRTTGLSTRAKTFVGTVNFTSPEVLNADDDSPYTVSSDIWSVGATVINMISGKAPLHDCLPP-KVIIKISSEKKLELPESQLMSAEMKSFIEEMLNPDPDQRPTAAQLLKLKLFS 705

HSP 2 Score: 175.252 bits (443), Expect = 1.343e-46
Identity = 85/232 (36.64%), Postives = 141/232 (60.78%), Query Frame = 3 
Query:  144 EFELFIDAVERNSAKSFSEYFKSEYLNSKDKNSMLPIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNLSPMVIA--ERNKDLINML---NAGVEARQLRQQ 824
            +FELF++A+   S + F  YFK+EYL  +D      IH ACY+GH++++++LI+  CD+E   + + RP+H AC + H + +K+L+  NC+I + +    +P+H AC  GH+  ++ LI+  C++E     N RP+H+A  HG +E +K+LI++ CD+E     N RPIH AC     E +++LI++ CDIEA   +N  P+ +A    N + I +L      +EA   ++Q
Sbjct:    4 QFELFMEAIISGSTELFGRYFKAEYLEREDTKGWRSIHHACYQGHSEVIKLLITHNCDIETHDEDDQRPIHLACYQRHSEAVKLLIEHNCDIEALDGWKQRPIHHACYQGHSEAVKLLIEHNCDIEALDGWNWRPIHIACYHGHSEAIKLLIEHNCDIEALNGWNRRPIHLACDQGHSEAVKLLIENKCDIEALDIWNQRPIHLACYHGNSEAIKLLIEHKCDIEALDWQKQ 235

HSP 3 Score: 168.703 bits (426), Expect = 2.163e-44
Identity = 77/170 (45.29%), Postives = 113/170 (66.47%), Query Frame = 3 
Query:  249 PIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNLSPMVIA 758
            PIH ACY+GH++ V++LI   CD+EA   +N RP+H AC  GH + +K+L+  NC+I + N  + +P+HLAC  GH+  ++ LI+ KC++E     N RP+HLA  HG +E +K+LI++KCD+E    +  RPIH AC   R E +++LIDH CDIEA    N  P+ +A
Sbjct:  105 PIHHACYQGHSEAVKLLIEHNCDIEALDGWNWRPIHIACYHGHSEAIKLLIEHNCDIEALNGWNRRPIHLACDQGHSEAVKLLIENKCDIEALDIWNQRPIHLACYHGNSEAIKLLIEHKCDIEALDWQKQRPIHLACYQGRSEAVKLLIDHKCDIEALDWLNQRPIHLA 274

HSP 4 Score: 164.081 bits (414), Expect = 8.316e-43
Identity = 78/185 (42.16%), Postives = 120/185 (64.86%), Query Frame = 3 
Query:  249 PIHIACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQNCNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLASAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNCDIEACADFNLSPMVIAER--NKDLINMLNAG 797
            PIHIACY GH++ +++LI   CD+EA   +N RP+H AC +GH + +K+L+   C+I + +  + +P+HLAC  G++  ++ LI+ KC++E       RP+HLA   G++E +K+LID+KCD+E     N RPIH AC     E +++LIDH C+IEA      SP+ +AE+  NK +I +LN  
Sbjct:  138 PIHIACYHGHSEAIKLLIEHNCDIEALNGWNRRPIHLACDQGHSEAVKLLIENKCDIEALDIWNQRPIHLACYHGNSEAIKLLIEHKCDIEALDWQKQRPIHLACYQGRSEAVKLLIDHKCDIEALDWLNQRPIHLACDQGYSEAVKLLIDHKCNIEALDGNGDSPLALAEKTGNKGIICILNGA 322
The following BLAST results are available for this feature:
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP3K32.586e-4838.02mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K32.785e-4838.02mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K33.157e-4838.02mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K33.157e-4838.02mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K33.382e-4838.02mitogen-activated protein kinase kinase kinase 3 [... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gck-11.691e-3634.19Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
gck-12.008e-3634.88Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
nsy-12.026e-3634.62Mitogen-activated protein kinase kinase kinase nsy... [more]
gck-12.137e-3634.88Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
nsy-12.250e-3634.62Mitogen-activated protein kinase kinase kinase nsy... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
GckIII9.960e-3733.20gene:FBgn0266465 transcript:FBtr0083399[more]
Mekk15.111e-3630.41gene:FBgn0024329 transcript:FBtr0083684[more]
Mekk15.250e-3630.41gene:FBgn0024329 transcript:FBtr0331353[more]
Ask16.165e-3534.75gene:FBgn0014006 transcript:FBtr0300256[more]
Ask18.813e-3534.75gene:FBgn0014006 transcript:FBtr0083819[more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k34.628e-5039.16mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k39.315e-5039.16mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k31.235e-4939.16mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k28.759e-4638.40mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k159.635e-4639.39mitogen-activated protein kinase kinase kinase 15 ... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
samd81.613e-4938.40sterile alpha motif domain containing 8 [Source:Xe... [more]
samd81.684e-4938.40sterile alpha motif domain containing 8 [Source:Xe... [more]
dennd1a7.902e-4935.22DENN domain containing 1A [Source:Xenbase;Acc:XB-G... [more]
dennd1a8.703e-4935.22DENN domain containing 1A [Source:Xenbase;Acc:XB-G... [more]
MAP3K26.758e-4738.17mitogen-activated protein kinase kinase kinase 2 [... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Map3k31.793e-4838.87mitogen-activated protein kinase kinase kinase 3 [... [more]
Map3k151.500e-4640.53mitogen-activated protein kinase kinase kinase 15 ... [more]
Map3k28.024e-4537.16mitogen-activated protein kinase kinase kinase 2 [... [more]
Map3k61.274e-3936.40mitogen-activated protein kinase kinase kinase 6 [... [more]
Map3k52.743e-3937.93mitogen-activated protein kinase kinase kinase 5 [... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q99759|M3K3_HUMAN1.242e-4738.02Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|Q61084|M3K3_MOUSE1.254e-4738.87Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|A2AQW0|M3K15_MOUSE1.049e-4540.53Mitogen-activated protein kinase kinase kinase 15 ... [more]
sp|Q6ZN16|M3K15_HUMAN2.977e-4540.23Mitogen-activated protein kinase kinase kinase 15 ... [more]
sp|Q9Y2U5|M3K2_HUMAN3.187e-4437.16Mitogen-activated protein kinase kinase kinase 2 O... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0H3YJG22.371e-7036.95Slc42a-1 OS=Schmidtea mediterranea OX=79327 GN=slc... [more]
A7S4G71.329e-5239.54Predicted protein (Fragment) OS=Nematostella vecte... [more]
A0A267FTA21.864e-4939.10Protein kinase domain-containing protein OS=Macros... [more]
A0A210PFZ52.402e-4938.64Mitogen-activated protein kinase kinase kinase 2 O... [more]
A0A1I8I3V24.726e-4938.72Protein kinase domain-containing protein OS=Macros... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k32.573e-5039.16mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k32.573e-5039.16mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k32.573e-5039.16mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k27.081e-4638.78mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k151.570e-4539.77mitogen-activated protein kinase kinase kinase 15 ... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k21.391e-4837.22mitogen-activated protein kinase kinase kinase 2 [... [more]
stk25a1.564e-3632.97serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-G... [more]
slka1.269e-3536.84STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-0504... [more]
ENSPMAT00000008193.11.040e-3131.43pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-... [more]
ENSPMAT00000002962.13.995e-3131.91pep scaffold:Pmarinus_7.0:GL476671:16080:33623:-1 ... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
CDC151.617e-4037.40Protein kinase of the Mitotic Exit Network; locali... [more]
STE202.677e-3534.43Cdc42p-activated signal transducing kinase; involv... [more]
KIC14.352e-3336.26Protein kinase of the PAK/Ste20 family, required f... [more]
STE115.793e-3235.10Signal transducing MEK kinase; involved in pheromo... [more]
SSK228.640e-3131.83MAP kinase kinase kinase of HOG1 mitogen-activated... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO414101.277e-5639.54Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO319342.957e-3835.27Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO478213.601e-3733.21Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO361506.499e-3630.15Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO428451.602e-3533.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k34.380e-4838.40mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k23.651e-4639.62mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k226.874e-4532.76mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k158.252e-4539.77mitogen-activated protein kinase kinase kinase 15 ... [more]
map3k228.512e-4533.56mitogen-activated protein kinase kinase kinase 3 [... [more]
back to top
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000016834.10.000e+097.88SMESG000016834.1[more]
SMESG000017261.15.873e-17246.14SMESG000017261.1[more]
SMESG000017274.19.125e-17247.74SMESG000017274.1[more]
SMESG000017274.11.182e-17147.49SMESG000017274.1[more]
SMESG000017084.13.389e-16147.01SMESG000017084.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30007714 ID=SMED30007714|Name=Mitogen-activated protein kinase kinase kinase 3|organism=Schmidtea mediterranea sexual|type=transcript|length=1815bp
TATTTAAGATATGTAATCACATCAATTCAAATAATAAACATATTTTTGAT
AAATTTAAAATTTTGGTGAATTGTTTCCGAATTCTGGAAAACAGCAAATT
GTTATTTTAAATGAATTTCTCTGACAGCTGTAGTTCGATAGACGAGTTCG
AATTGTTTATAGATGCAGTCGAGCGGAACTCAGCGAAATCATTTAGTGAA
TATTTCAAGAGCGAATATTTAAATAGTAAAGATAAAAACTCGATGCTGCC
GATCCATATTGCGTGCTATGAAGGGCACACGCAAATGGTGCAAATGCTTA
TTTCAAAAAAATGTGACCTTGAAGCATGCACAAAATATAATTGTCGGCCA
GTTCATTTTGCATGTGCCCGAGGTCACTTGGACATATTAAAAATCCTTGT
TAATCAGAACTGCAACATTCATTCGCATAATAAAGATCACTGGCAGCCGG
TTCATTTGGCATGTGCCTGTGGTCACACGGGCATATTACAGTTCCTCATC
GATCAGAAGTGCAACCTAGAAACATGTGCTGATAATAATTTGCGCCCGGT
CCATTTAGCAAGTGCCCACGGTCAAGCGGAAATATTAAAAGTCCTAATTG
ATAATAAGTGTGACCTTGAAATATGTGCCGATAAAAATTTGCGTCCGATT
CATTTTGCATGTGCTAATGATCGAGTGGAAGTGTTACAAATTCTTATCGA
TCATAATTGTGATATTGAGGCTTGTGCTGACTTTAATTTGTCTCCGATGG
TCATCGCTGAACGCAATAAGGACCTCATAAATATGCTCAATGCTGGGGTG
GAAGCACGGCAGCTAAGGCAACAAATTTCCGCAATGGGATTGCAGTGCAA
TTCTCAATGTGACCATAAACTGTGTCCTAAATCACTGGAATCAAAAAAAT
TTCATAGAGGTGAAGAAATTGGCCACGGAGCATTTGGAACAGTATTCCAT
TGTAAAGGATCAGGGATTGATAGGTCTTTCGCAATTAAATTTATCAATTA
TACAAAATTTGACAAGAGAGATATTGAACTAAATATCAATAGTTTCCTCC
CTATGCTCAAAAATGCAAGAATTGTTCAATATTTTGGAGCAATTAAAACG
GAATCTGAATTGTGCATTTTTATGGAATTCCTTCCTTTGGGATCTCTCAA
TGATAAAATAAGCAGAGAACGCTCCATAAAACCTGACAATGTCATCCGCT
ACTCCAGGCAGATACTTGAAGGATTGGAATTTCTTCATGGGAAAAAAATT
ATTCATCGAGATTTAAAGCCGGGAAACATTTTGATGGATGACGAGAATAA
TATAAAATTGGCAGATTTTGGCATCAGCCGTTTATTAATTAGAACTGATG
GTATCTCGATTGATACCAAATCATTTGCTGGGACACCGAATTTTACTGCT
CCAGAAATTATGAGCGGAGATCCTTACAATGTGCCTGCGGACATTTGGTC
GCTGGGGGCTACAATCATCAACATGATTACTAGTCAGCCGCCTTATCATG
ATTTGGAAACGCCATGGGCTGTAATATTCAAAATTGGTAATGAGAAAAAA
CTAGAATTGCCTTCAGATATTTCCGAGGAGATGAGGATTTTCATATTAGA
TTTGCTTCAGCCCGACCCCAAAGACCGCCCGACTGCAGCAGAGTTGTTAA
AGTCTAAATTTCTTTCACAGTAAATTGAAATAATTTATTCCACAAATTAT
TTTGGTCTTTGTTTTATATTATTGCCAATAATTTTTAAATGTTTTGTTTT
AATTTGCATCGGATTTTTTTATTTGTAAAATTAAAAATCATGTAAAGGTG
CCAAATAAATAAAAG
back to top

protein sequence of SMED30007714-orf-1

>SMED30007714-orf-1 ID=SMED30007714-orf-1|Name=SMED30007714-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=521bp
MNFSDSCSSIDEFELFIDAVERNSAKSFSEYFKSEYLNSKDKNSMLPIHI
ACYEGHTQMVQMLISKKCDLEACTKYNCRPVHFACARGHLDILKILVNQN
CNIHSHNKDHWQPVHLACACGHTGILQFLIDQKCNLETCADNNLRPVHLA
SAHGQAEILKVLIDNKCDLEICADKNLRPIHFACANDRVEVLQILIDHNC
DIEACADFNLSPMVIAERNKDLINMLNAGVEARQLRQQISAMGLQCNSQC
DHKLCPKSLESKKFHRGEEIGHGAFGTVFHCKGSGIDRSFAIKFINYTKF
DKRDIELNINSFLPMLKNARIVQYFGAIKTESELCIFMEFLPLGSLNDKI
SRERSIKPDNVIRYSRQILEGLEFLHGKKIIHRDLKPGNILMDDENNIKL
ADFGISRLLIRTDGISIDTKSFAGTPNFTAPEIMSGDPYNVPADIWSLGA
TIINMITSQPPYHDLETPWAVIFKIGNEKKLELPSDISEEMRIFILDLLQ
PDPKDRPTAAELLKSKFLSQ*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0003001lateral region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR036770Ankyrin_rpt-contain_sf
IPR002110Ankyrin_rpt
IPR000719Prot_kinase_dom
IPR020683Ankyrin_rpt-contain_dom
IPR008271Ser/Thr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0004709MAP kinase kinase kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0000165MAPK cascade
GO:0000186activation of MAPKK activity
GO:0016310phosphorylation
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 264..518
e-value: 5.2E-80
score: 281.8
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 264..518
e-value: 6.5E-62
score: 209.3
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 264..518
score: 47.071
IPR002110Ankyrin repeatSMARTSM00248ANK_2acoord: 76..105
e-value: 0.013
score: 24.7
coord: 109..138
e-value: 0.22
score: 20.6
coord: 142..171
e-value: 0.15
score: 21.1
coord: 175..204
e-value: 0.12
score: 21.5
coord: 43..72
e-value: 0.0046
score: 26.2
IPR002110Ankyrin repeatPFAMPF00023Ankcoord: 47..74
e-value: 0.016
score: 15.6
IPR002110Ankyrin repeatPROSITEPS50088ANK_REPEATcoord: 76..108
score: 9.725
IPR002110Ankyrin repeatPROSITEPS50088ANK_REPEATcoord: 43..75
score: 9.591
IPR002110Ankyrin repeatPROSITEPS50088ANK_REPEATcoord: 175..207
score: 9.03
IPR002110Ankyrin repeatPROSITEPS50088ANK_REPEATcoord: 142..174
score: 9.164
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 245..520
e-value: 8.9E-72
score: 243.4
NoneNo IPR availablePIRSFPIRSF000654ILKcoord: 140..516
e-value: 9.0E-46
score: 154.1
coord: 19..82
e-value: 9.7E-7
score: 25.4
coord: 77..147
e-value: 1.6E-7
score: 27.9
NoneNo IPR availablePANTHERPTHR11584SERINE/THREONINE PROTEIN KINASEcoord: 247..518
NoneNo IPR availablePANTHERPTHR11584:SF369APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM Ccoord: 247..518
IPR036770Ankyrin repeat-containing domain superfamilyGENE3DG3DSA:1.25.40.20coord: 11..115
e-value: 2.3E-23
score: 84.2
IPR036770Ankyrin repeat-containing domain superfamilyGENE3DG3DSA:1.25.40.20coord: 116..230
e-value: 2.8E-23
score: 84.2
IPR036770Ankyrin repeat-containing domain superfamilySUPERFAMILYSSF48403Ankyrin repeatcoord: 15..219
IPR020683Ankyrin repeat-containing domainPFAMPF12796Ank_2coord: 82..170
e-value: 1.2E-12
score: 48.3
IPR020683Ankyrin repeat-containing domainPROSITEPS50297ANK_REP_REGIONcoord: 37..216
score: 39.894
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 270..293
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 380..392
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 262..518