Peroxisomal biogenesis factor 2

Overview
NamePeroxisomal biogenesis factor 2
Smed IDSMED30007676
Length (bp)916
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Peroxisomal biogenesis factor 2 (SMED30007676) t-SNE clustered cells

Violin plots show distribution of expression levels for Peroxisomal biogenesis factor 2 (SMED30007676) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Peroxisomal biogenesis factor 2 (SMED30007676) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Peroxisomal biogenesis factor 2 (SMED30007676) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30007676

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
neoblastSMED30007676 dd_Smed_v4_11478_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Category 2 cellSMED30007676 dd_Smed_v4_11478_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Human
Match: PEX2 (peroxisomal biogenesis factor 2 [Source:HGNC Symbol;Acc:HGNC:9717])

HSP 1 Score: 104.375 bits (259), Expect = 2.208e-25
Identity = 70/258 (27.13%), Postives = 120/258 (46.51%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKC-FADILKLIANFYVLFINVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSFSN--RIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +       F   +K     ++    ++  ++T G   LN+K   D           K  KI+Y +     R L+   ++ FR    +SF    + +  +  L     +INF+ FL+R ++  +  R L +H +F  P +   ++GFEY NRELLWH F E + + +P  N  + K ++        G       L +    C +C      P  + C H FCY+CA++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKACLWVFLWRFTIYSKNATVGQSVLNIKYKNDFSPNLRYQPPSKNQKIWYAVCTIGGRWLEERCYDLFRNHHLASFGKVKQCVNFVIGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKPQNIC-EVGFEYMNRELLWHGFAEFLIFLLPLINVQKLKAKLSSWCIPLTGAPNSDNTLATSGKECALCGEWPTMPHTIGCEHIFCYFCAKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Human
Match: PEX2 (peroxisomal biogenesis factor 2 [Source:HGNC Symbol;Acc:HGNC:9717])

HSP 1 Score: 104.375 bits (259), Expect = 2.208e-25
Identity = 70/258 (27.13%), Postives = 120/258 (46.51%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKC-FADILKLIANFYVLFINVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSFSN--RIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +       F   +K     ++    ++  ++T G   LN+K   D           K  KI+Y +     R L+   ++ FR    +SF    + +  +  L     +INF+ FL+R ++  +  R L +H +F  P +   ++GFEY NRELLWH F E + + +P  N  + K ++        G       L +    C +C      P  + C H FCY+CA++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKACLWVFLWRFTIYSKNATVGQSVLNIKYKNDFSPNLRYQPPSKNQKIWYAVCTIGGRWLEERCYDLFRNHHLASFGKVKQCVNFVIGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKPQNIC-EVGFEYMNRELLWHGFAEFLIFLLPLINVQKLKAKLSSWCIPLTGAPNSDNTLATSGKECALCGEWPTMPHTIGCEHIFCYFCAKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Human
Match: PEX2 (peroxisomal biogenesis factor 2 [Source:HGNC Symbol;Acc:HGNC:9717])

HSP 1 Score: 104.375 bits (259), Expect = 2.208e-25
Identity = 70/258 (27.13%), Postives = 120/258 (46.51%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKC-FADILKLIANFYVLFINVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSFSN--RIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +       F   +K     ++    ++  ++T G   LN+K   D           K  KI+Y +     R L+   ++ FR    +SF    + +  +  L     +INF+ FL+R ++  +  R L +H +F  P +   ++GFEY NRELLWH F E + + +P  N  + K ++        G       L +    C +C      P  + C H FCY+CA++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKACLWVFLWRFTIYSKNATVGQSVLNIKYKNDFSPNLRYQPPSKNQKIWYAVCTIGGRWLEERCYDLFRNHHLASFGKVKQCVNFVIGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKPQNIC-EVGFEYMNRELLWHGFAEFLIFLLPLINVQKLKAKLSSWCIPLTGAPNSDNTLATSGKECALCGEWPTMPHTIGCEHIFCYFCAKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Human
Match: PEX2 (peroxisomal biogenesis factor 2 [Source:HGNC Symbol;Acc:HGNC:9717])

HSP 1 Score: 51.6026 bits (122), Expect = 2.592e-7
Identity = 41/163 (25.15%), Postives = 76/163 (46.63%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKC-FADILKLIANFYVLFINVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSFS--NRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIF 536
            LR+ QLDALE++ ALE+++ + F +  + +       F   +K     ++    ++  ++T G   LN+K   D           K  KI+Y +     R L+   ++ FR    +SF    + +  +  L     +INF+ FL+R ++  +  R L +H +F
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKACLWVFLWRFTIYSKNATVGQSVLNIKYKNDFSPNLRYQPPSKNQKIWYAVCTIGGRWLEERCYDLFRNHHLASFGKVKQCVNFVIGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVF 177
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Celegans
Match: prx-2 (PeRoXisome assembly factor [Source:UniProtKB/TrEMBL;Acc:Q23601])

HSP 1 Score: 73.559 bits (179), Expect = 7.488e-15
Identity = 65/265 (24.53%), Postives = 121/265 (45.66%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKIINNFIENIYPYSSQQKCFADIL--KLIANF-----YVLFINVHQSDSTYGMRQLNLKISADIKYVKIFYPILLTFERLLDYL-EFNTFRQSSFSNRI-----IKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIKFGFQRKSFPLLSINDL-CTICNFRLNNP-VRLECGHFFCYYCAENDLFVEKMGYLCRICSQ 848
            LRV QLDA  +D  +  I  + ++++    +Q   +   +  KL          VL+ +     ++ G  Q+      DI Y   + P L+T   +++ +  + T R S  S RI        I+A+Y   ++++F++FL+   +  +     +L    ++ P+ +  I ++  NREL+WH+F ++I    PF  + R+++  K    RK    +  +D+ C +C+     P V  +CGH  CY C             C +CS+
Sbjct:    6 LRVDQLDAHVLDSEIRSIAQDSVDDVV---NQMPLWVARIFEKLRPELKVTLEAVLWTHRFSRGASPGQEQM------DIAYAG-YTPKLITSHFMVEVIVPYLTRRMSELSGRIDISRMYSKIEAIYELGSLLHFLYFLRSGGHSTITESIFSLRNWNNHQPTIS-SINYDTQNRELMWHAFRDVILLTYPFIEKARQRIVKKQKLDRKFTSSIGSSDIECVVCDKPSVIPMVGQKCGHVACYTC-----IATSRNMTCPLCSE 254
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Fly
Match: Pex2 (gene:FBgn0035876 transcript:FBtr0076602)

HSP 1 Score: 83.1889 bits (204), Expect = 3.787e-18
Identity = 75/283 (26.50%), Postives = 127/283 (44.88%), Query Frame = 3 
Query:   81 EKITYPLRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADI---LKLIANFYVLFINVHQSDSTYGMRQLNLKISADIKYVK--IFYPILLTFERLL-DYLEFNTFRQSSFSNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCN--ELRRKMEIKFGFQRKSF----------PLLSINDLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICSQLSASSICQ 872
            EK  Y  RV Q+DA+ ++  + ++I +N +EN+   S     F  I   L LI    + F +V +  ST+G + L L   A+   V   + + IL      +  + E    R+  + +  I  ++       ++N+  FLK  R P +    L L  I S   ++ R IG++Y  RELLW  F E++   +P  N  +L+R ++  + F  +            P ++++  CT C  R   P  + CGH +CYYC   ++  +   + C  C      S  Q
Sbjct:    2 EKNKYVPRVNQIDAIYLNKDIARLIRDNLLENLQAISP--VLFIKIQPELDLIIQSAIWFGSVGKRCSTFGQQLLVLAYDAEKLTVSRLVLHFILTVLPGYVKSWEERRLTRRVEWFSEAIMWVENSALILNILNYFRFLKTGRKPTLVDYLLGLDYI-SLRNNQRRDIGYKYLTRELLWGGFMEILGLVLPIINFRKLQRVLK-SWTFSGRRLEDRDGPAFLAPQMTLSTTCTFCGERPTLPHHMGCGHIYCYYCLNANVLTDA-SFCCPNCGSACPESGIQ 279
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Zebrafish
Match: pex2 (peroxisomal biogenesis factor 2 [Source:ZFIN;Acc:ZDB-GENE-070530-2])

HSP 1 Score: 94.3597 bits (233), Expect = 6.532e-22
Identity = 73/278 (26.26%), Postives = 118/278 (42.45%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKIINNFIENIYPYSSQQKCF----ADILKLI-------ANFYVLFINVHQSDSTYGMRQLNLK----ISADIKYVKIFYPILLTFERLLDYLEFNTFRQSSFS--------------NRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIKFGFQRKSFPLLSINDL----------CTICNFRLNNPVRLECGHFFCYYCAENDLFVE 815
            LR+ QLDA E+D ALE+++         +S   +CF      IL  +           +    ++ + +T G   LN++    +    KY  +  P    F  LL   E   FR+ S S               +++ ++  L    +++NF+ FL+R  +P +  R L +  +FS P    R I F+Y NRELLWH F E + + +P  N  + K  +   F     PL  +             C IC      P  + C H FCYYC ++++  +
Sbjct:   22 LRISQLDAFELDGALEQLV---------WSQFTQCFQHFKPGILTPVEPELKALLQLLLWRFTIYSNSATVGQSLLNIRYKNALIPGQKYRPMSRPQKFWFA-LLTVGE-KWFRERSHSLFLNHPAESNARKARKVLSILLGLTKAASLVNFLLFLQRGTFPTLTERLLGVQPVFSRP-QGPRDINFQYLNRELLWHGFAEFLIFLLPLINVWKLKAGVSALFS----PLSDLTGTQSSEETHLTECAICGEWPTMPHSIGCKHVFCYYCVKSNVIAD 283
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Xenopus
Match: ndrg2 (NDRG family member 2 [Source:Xenbase;Acc:XB-GENE-951910])

HSP 1 Score: 106.301 bits (264), Expect = 4.169e-26
Identity = 73/281 (25.98%), Postives = 128/281 (45.55%), Query Frame = 3 
Query:   81 EKITYPLRVVQLDALEIDDALEKII----NNFIENIYPYSSQQKCFADILKLIANFYVLFINVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQSSFSNRI------IKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEI------KFGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICS 845
            E+I   LR+ QLDA+E++ ALE++I    N+  +   P    +  F   +K     ++    ++  ++T G   LN++   D+          K  K+++ + +   + L+   F+ F    F          +  I  L     ++NF+ FL++ ++  +  R L +  +FS P    RQ+GFEY NRE+LWH F E + + +P  N  + K ++        G       L  I   C +C      P  + C H FCYYC +++ ++  M + C  CS
Sbjct:    9 EEINPVLRISQLDAIELNKALEQLIWSQFNSCFQGFKPGLLTR--FEPEIKAFLCLFLWRYTIYTKNATVGQAILNMQYKNDLEATKNYRPLNKQQKVWFALFMVGGKWLEERSFDLFSNHPFGASFQRTKYFLNAISGLLKFGALLNFLIFLQQGKFATLTERLLGIRSVFSRP-QDVRQVGFEYMNREILWHGFAEFLIFLLPLINTQKLKSKLFSWCKPAKGHSLSDPSLAVICKECCLCGEWPAMPHTIGCSHVFCYYCIKSN-YMADMYFTCPKCS 285
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Mouse
Match: Pex2 (peroxisomal biogenesis factor 2 [Source:MGI Symbol;Acc:MGI:107486])

HSP 1 Score: 103.99 bits (258), Expect = 2.124e-25
Identity = 70/260 (26.92%), Postives = 122/260 (46.92%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSF--SNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++   D           K  K++Y +     + L+   ++ FR    +SF  + + +  +  L     +INF+ FL++ ++  +  R L +H +F  P    R++GFEY NRELLWH F E + + +P  N  + K ++        G       L S    C +C      P  + C H FCYYC ++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSLNLIYQPPSKTQKLWYAVCTIGGKWLEERCYDLFRNRHLASFGKAKQFMNFLVGLLKLGELINFLIFLQKGKFATLTERLLGIHSVFCKP-QNMREVGFEYMNRELLWHGFAEFLIFLLPLINIQKLKAKLSSWCIPLTGAAGHDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Mouse
Match: Pex2 (peroxisomal biogenesis factor 2 [Source:MGI Symbol;Acc:MGI:107486])

HSP 1 Score: 103.99 bits (258), Expect = 2.124e-25
Identity = 70/260 (26.92%), Postives = 122/260 (46.92%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSF--SNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++   D           K  K++Y +     + L+   ++ FR    +SF  + + +  +  L     +INF+ FL++ ++  +  R L +H +F  P    R++GFEY NRELLWH F E + + +P  N  + K ++        G       L S    C +C      P  + C H FCYYC ++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSLNLIYQPPSKTQKLWYAVCTIGGKWLEERCYDLFRNRHLASFGKAKQFMNFLVGLLKLGELINFLIFLQKGKFATLTERLLGIHSVFCKP-QNMREVGFEYMNRELLWHGFAEFLIFLLPLINIQKLKAKLSSWCIPLTGAAGHDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Mouse
Match: Pex2 (peroxisomal biogenesis factor 2 [Source:MGI Symbol;Acc:MGI:107486])

HSP 1 Score: 103.99 bits (258), Expect = 2.124e-25
Identity = 70/260 (26.92%), Postives = 122/260 (46.92%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSF--SNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++   D           K  K++Y +     + L+   ++ FR    +SF  + + +  +  L     +INF+ FL++ ++  +  R L +H +F  P    R++GFEY NRELLWH F E + + +P  N  + K ++        G       L S    C +C      P  + C H FCYYC ++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSLNLIYQPPSKTQKLWYAVCTIGGKWLEERCYDLFRNRHLASFGKAKQFMNFLVGLLKLGELINFLIFLQKGKFATLTERLLGIHSVFCKP-QNMREVGFEYMNRELLWHGFAEFLIFLLPLINIQKLKAKLSSWCIPLTGAAGHDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Mouse
Match: Pex2 (peroxisomal biogenesis factor 2 [Source:MGI Symbol;Acc:MGI:107486])

HSP 1 Score: 103.99 bits (258), Expect = 2.124e-25
Identity = 70/260 (26.92%), Postives = 122/260 (46.92%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSF--SNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++   D           K  K++Y +     + L+   ++ FR    +SF  + + +  +  L     +INF+ FL++ ++  +  R L +H +F  P    R++GFEY NRELLWH F E + + +P  N  + K ++        G       L S    C +C      P  + C H FCYYC ++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSLNLIYQPPSKTQKLWYAVCTIGGKWLEERCYDLFRNRHLASFGKAKQFMNFLVGLLKLGELINFLIFLQKGKFATLTERLLGIHSVFCKP-QNMREVGFEYMNRELLWHGFAEFLIFLLPLINIQKLKAKLSSWCIPLTGAAGHDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Mouse
Match: Pex2 (peroxisomal biogenesis factor 2 [Source:MGI Symbol;Acc:MGI:107486])

HSP 1 Score: 103.99 bits (258), Expect = 2.124e-25
Identity = 70/260 (26.92%), Postives = 122/260 (46.92%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSF--SNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++   D           K  K++Y +     + L+   ++ FR    +SF  + + +  +  L     +INF+ FL++ ++  +  R L +H +F  P    R++GFEY NRELLWH F E + + +P  N  + K ++        G       L S    C +C      P  + C H FCYYC ++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSLNLIYQPPSKTQKLWYAVCTIGGKWLEERCYDLFRNRHLASFGKAKQFMNFLVGLLKLGELINFLIFLQKGKFATLTERLLGIHSVFCKP-QNMREVGFEYMNRELLWHGFAEFLIFLLPLINIQKLKAKLSSWCIPLTGAAGHDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. UniProt/SwissProt
Match: sp|P28328|PEX2_HUMAN (Peroxisome biogenesis factor 2 OS=Homo sapiens OX=9606 GN=PEX2 PE=1 SV=2)

HSP 1 Score: 104.375 bits (259), Expect = 1.060e-24
Identity = 70/258 (27.13%), Postives = 120/258 (46.51%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKC-FADILKLIANFYVLFINVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSFSN--RIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +       F   +K     ++    ++  ++T G   LN+K   D           K  KI+Y +     R L+   ++ FR    +SF    + +  +  L     +INF+ FL+R ++  +  R L +H +F  P +   ++GFEY NRELLWH F E + + +P  N  + K ++        G       L +    C +C      P  + C H FCY+CA++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKACLWVFLWRFTIYSKNATVGQSVLNIKYKNDFSPNLRYQPPSKNQKIWYAVCTIGGRWLEERCYDLFRNHHLASFGKVKQCVNFVIGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKPQNIC-EVGFEYMNRELLWHGFAEFLIFLLPLINVQKLKAKLSSWCIPLTGAPNSDNTLATSGKECALCGEWPTMPHTIGCEHIFCYFCAKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. UniProt/SwissProt
Match: sp|P24392|PEX2_RAT (Peroxisome biogenesis factor 2 OS=Rattus norvegicus OX=10116 GN=Pex2 PE=2 SV=1)

HSP 1 Score: 104.375 bits (259), Expect = 1.174e-24
Identity = 74/274 (27.01%), Postives = 127/274 (46.35%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSF--SNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICS 845
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++   D           K  K+ Y +     R L+   ++ FR    +SF  + + +  +  L     ++NF+ FL++ ++  +  R L +H +F  P S  R++GFEY NRELLWH F E + + +P  N  + K ++                L S    C +C      P  + C H FCYYC ++  F+  M + C  C 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSPNPVYQPPSKNQKLLYAVCTIGGRWLEERCYDLFRNRHLASFGKAKQCMNFVVGLLKLGELMNFLIFLQKGKFATLTERLLGIHSVFCKPQS-MREVGFEYMNRELLWHGFAEFLVFLLPLINIQKLKAKLSSWCIPLTSTAGSDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSS-FLFDMYFTCPKCG 284
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. UniProt/SwissProt
Match: sp|P55098|PEX2_MOUSE (Peroxisome biogenesis factor 2 OS=Mus musculus OX=10090 GN=Pex2 PE=2 SV=1)

HSP 1 Score: 102.834 bits (255), Expect = 3.261e-24
Identity = 70/260 (26.92%), Postives = 121/260 (46.54%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSF--SNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAEND 803
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++   D           K  K+ Y +     R L+   ++ FR    +SF  + + +  +  L     ++NF+ FL++ ++  +  R L +H +F  P    R++GFEY NRELLWH F E + + +P  N  + K ++        G       L S    C +C      P  + C H FCYYC ++ 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQHKNDSSPNPVYQPPSKNQKLLYAVCTIGGRWLEERCYDLFRNRHLASFGKAKQCMNFVVGLLKLGELMNFLIFLQKGKFATLTERLLGIHSVFCKP-QNMREVGFEYMNRELLWHGFAEFLIFLLPLINIQKLKAKLSSWCTLCTGAAGHDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSS 271
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. UniProt/SwissProt
Match: sp|Q06438|PEX2_CRIGR (Peroxisome biogenesis factor 2 OS=Cricetulus griseus OX=10029 GN=PEX2 PE=1 SV=1)

HSP 1 Score: 101.293 bits (251), Expect = 1.525e-23
Identity = 75/284 (26.41%), Postives = 132/284 (46.48%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKC-FADILKLIANFYVLFINVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSFSN--RIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICSQLSASSICQLRS 881
            LR+ QLDALE++ ALE+++ + F +  + +       F   +K     ++    ++  ++T G   LN++   D           K  K++Y +     R L+   ++ FR    +SF    + + ++  L     +INF+ FL++ ++  +  R L +H +F  P    R++GF+Y NRELLWH F E + + +P  N  + K ++        G       L S    C +C      P  + C H FCYYC ++  F+  M + C  C  +   S+  L+S
Sbjct:   14 LRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKACLWLFLWRFTIYSKNATVGQSVLNIQYKNDFSSNSRYQPPSKNQKLWYAVCTIGGRWLEERCYDLFRNRHLASFGKVKQCMNVMVGLLKLGELINFLIFLQKGKFATLTERLLGIHSVFCKP-QNIREVGFDYMNRELLWHGFAEFLIFLLPLINIQKFKAKLSSWCIPLTGAASSDSALASSGKECALCGEWPTMPHTIGCEHVFCYYCVKSS-FLFDMYFTCPKCG-IEVHSVQPLKS 294
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. UniProt/SwissProt
Match: sp|Q75JQ3|PEX2_DICDI (Peroxisome biogenesis factor 2 OS=Dictyostelium discoideum OX=44689 GN=pex2 PE=3 SV=1)

HSP 1 Score: 70.0922 bits (170), Expect = 2.899e-12
Identity = 49/170 (28.82%), Postives = 79/170 (46.47%), Query Frame = 3 
Query:  432 QALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRK-----MEIKFGF--------QRKSFPLLSINDL-------------CTICNFRLNNPVRL----ECGHFFCYYCAENDLFVEKMGYLCRICSQL 851
            ++ Y    ++NF+ FL   +Y  +  R L++ L++++P + +R I FEY NR L+WH F E I + MP  N  R K     + +K  F           S PL  +                C IC   +N+P+ +    +CGH FCYYC +    ++   + C  C+ L
Sbjct:  248 ESAYKALALLNFLTFLFNGKYVTLVNRILHMRLVYAHP-TLSRNISFEYMNRLLVWHGFTEFILFIMPLINIDRIKSFLYRLLVKTSFGNSSGNNNNTASNPLQQLQKQQLLIQQQQMALAKCPIC---MNDPISMPYSADCGHLFCYYCIKTSCMIDS-SFTCPRCNSL 412
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. TrEMBL
Match: F1RWL5 (Peroxisomal biogenesis factor 2 OS=Sus scrofa OX=9823 GN=PEX2 PE=4 SV=1)

HSP 1 Score: 118.242 bits (295), Expect = 2.502e-27
Identity = 77/274 (28.10%), Postives = 131/274 (47.81%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLK----ISADIKYV------KIFYPILLTFERLLDYLEFNTFRQSSFSN-----RIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIKF------GFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICS 845
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++     S D++Y       K++Y I     + L+   ++ FR   F++     + + L+  L     +INF+ FL+R ++  +  R L +H +F  P    R +GFEY NRELLWH F E + + +P  N  + K ++        G       L +   LC +C      P  + C H FCYYC ++  F+  M + C  C 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDFSPDLRYQPPSKTQKLWYAICTIGGKWLEERCYDVFRNRHFASFKKAKQCVHLVVGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKP-QNVRDVGFEYMNRELLWHGFAEFLIFLLPLVNIQKMKAKLSAWCTPVTGAPSGDGALGTSGKLCALCGEWPTMPHTMGCQHVFCYYCLKSS-FLFDMSFACPKCG 284
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. TrEMBL
Match: A0A4X1UJ97 (RING-type domain-containing protein OS=Sus scrofa OX=9823 GN=PEX2 PE=4 SV=1)

HSP 1 Score: 117.472 bits (293), Expect = 3.636e-27
Identity = 76/274 (27.74%), Postives = 131/274 (47.81%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLK----ISADIKYV------KIFYPILLTFERLLDYLEFNTFRQSSFSN-----RIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIKF------GFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICS 845
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++     S D++Y       K++Y +     + L+   ++ FR   F++     + + L+  L     +INF+ FL+R ++  +  R L +H +F  P    R +GFEY NRELLWH F E + + +P  N  + K ++        G       L +   LC +C      P  + C H FCYYC ++  F+  M + C  C 
Sbjct:   15 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDFSPDLRYQPPSKTQKLWYAVCTIGGKWLEERCYDVFRNRHFASFKKAKQCVHLVVGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKP-QNVRDVGFEYMNRELLWHGFAEFLIFLLPLVNIQKMKAKLSAWCTPVTGAPSGDGALGTSGKLCALCGEWPTMPHTMGCQHVFCYYCLKSS-FLFDMSFACPKCG 284
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. TrEMBL
Match: A0A480E925 (Peroxisomal biogenesis factor 2 OS=Sus scrofa OX=9823 GN=PEX2 PE=4 SV=1)

HSP 1 Score: 117.857 bits (294), Expect = 4.208e-27
Identity = 77/274 (28.10%), Postives = 131/274 (47.81%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLK----ISADIKYV------KIFYPILLTFERLLDYLEFNTFRQSSFSN-----RIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIKF------GFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICS 845
            LR+ QLDALE++ ALE+++ + F +  + +  +    A     +  F  LF+    ++  ++T G   LN++     S D++Y       K++Y I     + L+   ++ FR   F++     + + L+  L     +INF+ FL+R ++  +  R L +H +F  P    R +GFEY NRELLWH F E + + +P  N  + K ++        G       L +   LC +C      P  + C H FCYYC ++  F+  M + C  C 
Sbjct:   30 LRISQLDALELNKALEQLVWSQFTQCFHGF--KPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDFSPDLRYQPPSKTQKLWYAICTIGGKWLEERCYDVFRNRHFASFKKAKQCVHLVVGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKP-QNVRDVGFEYMNRELLWHGFAEFLIFLLPLVNIQKMKAKLSAWCTPVTGAPSGDGALGTSGKLCALCGEWPTMPHTMGCQHVFCYYCLKSS-FLFDMSFACPKCG 299
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. TrEMBL
Match: K7EW56 (Peroxisomal biogenesis factor 2 OS=Pelodiscus sinensis OX=13735 GN=PEX2 PE=4 SV=1)

HSP 1 Score: 114.775 bits (286), Expect = 4.286e-26
Identity = 79/281 (28.11%), Postives = 138/281 (49.11%), Query Frame = 3 
Query:   75 DGEKITYPLRVVQLDALEIDDALEKIINNFIENIYPYSSQQKCFADILKLIANFYVLFI---NVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLD---YLEFNTFRQSSF--SNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK-----FGFQRKSFPLLSIN-DLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICS 845
            + E++   LR+ QLDALE++ ALE+++ +   + + +  +    A I   +  F  +F+    ++  ++T G   LN++   D+          K+ K++Y I     R L+   Y  F++F+  SF  +   I  +  L     ++NF+ FL++ ++  +  R L +  +F  P    RQIGFEY NRELLWH F E + Y +P  N  + K++I           KS   L+++   C++C      P  + C H FCYYC +++   + M + C  C 
Sbjct:    7 NAERVNPVLRISQLDALELNKALEQLVWSQFSSCF-HGFKPGLLAHIEPEVKAFLWIFLWRFTIYSKNATVGQTILNIQYKNDLSHTQKYQPLSKHQKLWYLICTVGGRWLEERCYDLFSSFQLESFYRTKHFINFVAGLLKLCGLLNFLIFLQKGKFATLTERILGIRSVFCRP-QNLRQIGFEYINRELLWHGFAEFLIYLLPLINMQKLKLKISSWSLPIAVFSKSENCLAVHCKECSVCGEWPTMPHTIGCSHVFCYYCIKSNCLFD-MYFTCPKCG 284
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. TrEMBL
Match: H0XRG6 (Peroxisomal biogenesis factor 2 OS=Otolemur garnettii OX=30611 GN=PEX2 PE=4 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 5.327e-26
Identity = 76/272 (27.94%), Postives = 128/272 (47.06%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKII-NNFIENIYPYSSQQ-KCFADILKLIANFYVLFINVHQSDSTYGMRQLNLKISADI----------KYVKIFYPILLTFERLLDYLEFNTFRQ---SSFSN--RIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK------FGFQRKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICS 845
            LRV QLDALE++ ALE+++ + F +  + +      CF   +K +   ++    ++  ++T G   LN++   D           K  KI+Y +     R L+   ++ FR    +SF    + +  +  L     +INF+ FL++ ++  +  R L +H +FS P    R++GFEY NRELLWH F E + + +P  N  + K  +        G       L++    C +C      P  + C H FCYYC ++  F+  M + C  C 
Sbjct:   15 LRVSQLDALELNKALEQLVWSQFTQCFHGFKPGLLACFEPEVKALLWLFLWRFTIYSKNATVGQSVLNIQYKNDFSPNLRYQPPSKNQKIWYAVCTVGGRWLEERCYDLFRNRHLASFGKIKQCVNFMVGLSKLGGLINFLIFLQKGKFATLTERLLGIHSVFSKP-QNIREVGFEYMNRELLWHGFAEFLIFLLPLINIQKLKARLSSWCIPLTGAPNNDDTLITSGKECALCGEWPTMPHTIGCEHIFCYYCVKSS-FLFDMYFACPKCG 284
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Cavefish
Match: pex2 (peroxisomal biogenesis factor 2 [Source:NCBI gene;Acc:103035941])

HSP 1 Score: 83.5741 bits (205), Expect = 3.874e-18
Identity = 71/288 (24.65%), Postives = 118/288 (40.97%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKIINNFIENIYPYSSQQKCFADILKLI-----------ANFYVLFINVHQSDSTYGMRQLNLK----ISADIKY------VKIFYPILLTFERLLDYLEFNTFRQSSFSNRIIK-------LIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIKFGFQRKSFPLLSIN------DLCTICNFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICSQLSAS 860
            LR+ QLDA E+D ALE+++         +S   +CF      +               +    V+ + +T G   LN++    +    KY       K+++ +L    + L     + F     ++  I+       ++  L    ++ NF+ FL+   +P +  R L +  +FS P    R I F+Y NRELLWH F E + + +P  N  + K  +   F        S +        C IC      P  + C H FCYYC ++    + + + C  CS  S S
Sbjct:   22 LRISQLDAFELDGALEQLV---------WSQFARCFQHFKPGLLTPAEPELKALLQLLLWRFTVYSNSATVGQTLLNVRYRNALIPGQKYRPMSRQQKLWFALLTVGSKWLRERSHSLFLLGRPADAGIQKARGTLAVLSGLAKAASLFNFLLFLQSGTFPTLTERLLGVQPVFSRP-QGPRDINFQYVNRELLWHGFAEFLIFLLPLVNTWKLKSSLSALFSLSDKTKGSADAETAGRTECAICEEWPTMPHSIGCTHVFCYYCIKSHTMAD-IFFTCPKCSAESTS 298
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Sea Lamprey
Match: pex2 (peroxisomal biogenesis factor 2 [Source:ZFIN;Acc:ZDB-GENE-070530-2])

HSP 1 Score: 73.1738 bits (178), Expect = 3.066e-15
Identity = 64/271 (23.62%), Postives = 99/271 (36.53%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKIINNFIEN---------IYPYSSQQKCFADILKLIANFYVLFINVHQ--------SDSTYGMRQLNLKISADIKYVKIFYPILLTFERLLDYLEFNTFRQSSFSNRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELR-RKMEIKFGFQRKSFPLLSINDLCTICNFRLNNP-VRLECGHFFCYYC------AENDLFVEKMGYLCR 836
            LRV QLDALE+D  LE+++   +           +  +  + +    +L      Y     V Q        S   +G R ++L     + +  +        ER  D              +       L     ++ ++ FL+     ++  R L L+ + + P    RQ+GFEY NRELLWH F E + + +P  N  R R      G    +        +C  C      P     C H FCY+C      A  DL   + G   R
Sbjct:   13 LRVSQLDALELDRMLEQLLWEQLGRCFQAFRPGLLVGWEPELRALLRLLLWRFTLYSSEATVGQALLNIRYRSSYNHGGRHVSLSRRQKLWFAALTVGGGWASERWRDIYRGGAAALFPRLKKAAGTALGLLGATQLLAYVVFLRTGTGLSLTERLLGLNAVQARP-QGLRQVGFEYMNRELLWHGFAEFLLFVLPLVNAARLRFSPTAHGRAGGAKDPAEAATVCVACGEWPCLPHTAGGCAHVFCYHCLASRQAASADLACPRCGSPAR 282
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Nematostella
Match: EDO33162 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SSY6])

HSP 1 Score: 78.9518 bits (193), Expect = 1.170e-17
Identity = 42/117 (35.90%), Postives = 62/117 (52.99%), Query Frame = 3 
Query:  453 TVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIKFGFQRKSFP----LLSINDLCTICNFRLNNPVRLECGHFFCYYC 791
            ++INF+ FL++ RY ++  R L +H +F    S  RQ+ FE+  RELLWH F E + + +P  N  + K  I   F R + P    +      C+IC+     P +  C H FCYYC
Sbjct:   62 SMINFLVFLQKGRYQSLLERLLGIHHVFEQRQS-LRQVSFEFMTRELLWHGFAEFLFFLLPLINVHKLKNLIMRQFTRPALPSSPNVKVAFHQCSICSEPPTAPHQGACEHVFCYYC 177
[Close]
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Medaka
Match: pex2 (peroxisomal biogenesis factor 2 [Source:ZFIN;Acc:ZDB-GENE-070530-2])

HSP 1 Score: 75.8702 bits (185), Expect = 2.233e-15
Identity = 62/272 (22.79%), Postives = 109/272 (40.07%), Query Frame = 3 
Query:   99 LRVVQLDALEIDDALEKIINNFIENIYPYSSQQKCFADILKLI-------ANFYVLFINVHQSDSTYGMRQLNLKISADIKYVKIFYP----------ILLTFERLLDYLEFNTF-------RQSSFS----------NRIIKLIQALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYTNRELLWHSFNELITYFMPFCNELRRKMEIK---FGFQ----RKSFPLLSINDLCTICNFRLNNPVRLECGHFFCYYC 791
            LR+ QLDALE+D ALE+++     + +     Q C   +L  +           +    ++ + +T G   L+L+        + + P          +L    R L     +         R S F            + + L+  +    ++INF  FL+  R+P +  R      + S  P+  R + ++Y NRELLWH F + + + +P  +  + K  +    FG +    ++S     +   C +C      P  + C H FCYYC
Sbjct:   18 LRISQLDALELDAALEQLLWTRFSHCF-----QNCRPGLLTPVEPELRALLYLLLWRFTLYSNSATVGQSLLSLRYHRAGSLARRYRPLSPRQKLVLAVLAAGPRWLQDRSHSLLPLVGLGSRGSVFERDDGLFQQGLRKALTLVSGVAKFASLINFFIFLRNGRHPILSERIAGAQAVLSK-PNVTRDVTYQYMNRELLWHGFADFLIFLLPLMDTRKLKAAVSSFVFGEESSDRKESGERRELWKECGLCGEWPTMPHTVGCQHVFCYYC 283
The following BLAST results are available for this feature:
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
PEX22.208e-2527.13peroxisomal biogenesis factor 2 [Source:HGNC Symbo... [more]
PEX22.208e-2527.13peroxisomal biogenesis factor 2 [Source:HGNC Symbo... [more]
PEX22.208e-2527.13peroxisomal biogenesis factor 2 [Source:HGNC Symbo... [more]
PEX22.592e-725.15peroxisomal biogenesis factor 2 [Source:HGNC Symbo... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
prx-27.488e-1524.53PeRoXisome assembly factor [Source:UniProtKB/TrEM... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Pex23.787e-1826.50gene:FBgn0035876 transcript:FBtr0076602[more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pex26.532e-2226.26peroxisomal biogenesis factor 2 [Source:ZFIN;Acc:Z... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ndrg24.169e-2625.98NDRG family member 2 [Source:Xenbase;Acc:XB-GENE-9... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pex22.124e-2526.92peroxisomal biogenesis factor 2 [Source:MGI Symbol... [more]
Pex22.124e-2526.92peroxisomal biogenesis factor 2 [Source:MGI Symbol... [more]
Pex22.124e-2526.92peroxisomal biogenesis factor 2 [Source:MGI Symbol... [more]
Pex22.124e-2526.92peroxisomal biogenesis factor 2 [Source:MGI Symbol... [more]
Pex22.124e-2526.92peroxisomal biogenesis factor 2 [Source:MGI Symbol... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P28328|PEX2_HUMAN1.060e-2427.13Peroxisome biogenesis factor 2 OS=Homo sapiens OX=... [more]
sp|P24392|PEX2_RAT1.174e-2427.01Peroxisome biogenesis factor 2 OS=Rattus norvegicu... [more]
sp|P55098|PEX2_MOUSE3.261e-2426.92Peroxisome biogenesis factor 2 OS=Mus musculus OX=... [more]
sp|Q06438|PEX2_CRIGR1.525e-2326.41Peroxisome biogenesis factor 2 OS=Cricetulus grise... [more]
sp|Q75JQ3|PEX2_DICDI2.899e-1228.82Peroxisome biogenesis factor 2 OS=Dictyostelium di... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
F1RWL52.502e-2728.10Peroxisomal biogenesis factor 2 OS=Sus scrofa OX=9... [more]
A0A4X1UJ973.636e-2727.74RING-type domain-containing protein OS=Sus scrofa ... [more]
A0A480E9254.208e-2728.10Peroxisomal biogenesis factor 2 OS=Sus scrofa OX=9... [more]
K7EW564.286e-2628.11Peroxisomal biogenesis factor 2 OS=Pelodiscus sine... [more]
H0XRG65.327e-2627.94Peroxisomal biogenesis factor 2 OS=Otolemur garnet... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pex23.874e-1824.65peroxisomal biogenesis factor 2 [Source:NCBI gene;... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pex23.066e-1523.62peroxisomal biogenesis factor 2 [Source:ZFIN;Acc:Z... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO331621.170e-1735.90Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pex22.233e-1522.79peroxisomal biogenesis factor 2 [Source:ZFIN;Acc:Z... [more]
back to top
BLAST of Peroxisomal biogenesis factor 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30007676 ID=SMED30007676|Name=Peroxisomal biogenesis factor 2|organism=Schmidtea mediterranea sexual|type=transcript|length=916bp
TTTAAATTTATTTATAGTTTAATTAGTGAAAATATATTAATGATCATATT
CAATATATAATTTTTGCTTTTTAGGATGGCGAAAAAATAACTTATCCTTT
AAGAGTTGTTCAGTTAGATGCATTGGAAATAGATGACGCATTAGAAAAGA
TTATAAATAACTTCATTGAAAATATCTATCCATATTCTAGTCAACAAAAA
TGCTTCGCAGATATTCTTAAATTAATTGCTAATTTTTACGTGTTATTTAT
CAATGTTCATCAAAGCGATTCAACTTATGGAATGCGTCAATTGAACCTTA
AAATTAGTGCCGATATTAAATATGTTAAAATATTTTATCCGATTTTATTA
ACATTTGAAAGACTGTTAGATTATTTGGAATTTAATACTTTTCGGCAATC
TAGTTTCTCTAATCGAATTATAAAATTGATCCAAGCGCTATATAATACAT
TTACTGTGATTAATTTTATTTTTTTCCTCAAACGAGCTCGATATCCAAAC
GTATTTATGCGATTTCTCAATCTGCATCTCATCTTTTCAAATCCTCCATC
GAAAGCAAGACAAATCGGATTTGAATATACAAATCGTGAATTATTATGGC
ATTCTTTCAATGAGTTAATAACTTATTTCATGCCGTTTTGCAATGAATTA
AGGAGAAAAATGGAGATTAAATTCGGTTTTCAACGCAAAAGTTTTCCATT
GTTATCAATCAATGATTTGTGCACGATTTGCAATTTTCGCTTGAATAATC
CAGTTAGATTAGAATGTGGACATTTCTTTTGCTACTATTGCGCTGAAAAT
GATCTTTTCGTGGAGAAAATGGGATATTTATGTCGAATTTGTTCACAGCT
CTCGGCCAGCTCGATTTGTCAGTTGCGGAGCCAATCAAATGAAATTCTAA
TTTGAGTCGATTTGAG
back to top

protein sequence of SMED30007676-orf-1

>SMED30007676-orf-1 ID=SMED30007676-orf-1|Name=SMED30007676-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=208bp
MRQLNLKISADIKYVKIFYPILLTFERLLDYLEFNTFRQSSFSNRIIKLI
QALYNTFTVINFIFFLKRARYPNVFMRFLNLHLIFSNPPSKARQIGFEYT
NRELLWHSFNELITYFMPFCNELRRKMEIKFGFQRKSFPLLSINDLCTIC
NFRLNNPVRLECGHFFCYYCAENDLFVEKMGYLCRICSQLSASSICQLRS
QSNEILI*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0000038very long-chain fatty acid metabolic process
GO:0000122negative regulation of transcription from RNA polymerase II promoter
GO:0006635fatty acid beta-oxidation
GO:0007031peroxisome organization
GO:0016558protein import into peroxisome matrix
GO:0031648protein destabilization
GO:0048147negative regulation of fibroblast proliferation
GO:0050680negative regulation of epithelial cell proliferation
GO:0016055Wnt signaling pathway
GO:0016567protein ubiquitination
Vocabulary: cellular component
TermDefinition
GO:0005779integral component of peroxisomal membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0016593Cdc73/Paf1 complex
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000028Category 2 cell
Vocabulary: INTERPRO
TermDefinition
IPR001841Znf_RING
IPR006845Pex_N
IPR013083Znf_RING/FYVE/PHD
IPR017907Znf_RING_CS
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0008270zinc ion binding
GO:0046872metal ion binding
GO:0061630ubiquitin protein ligase activity
GO:0072572poly-ADP-D-ribose binding