Porphobilinogen deaminase

Overview
NamePorphobilinogen deaminase
Smed IDSMED30007511
Length (bp)1272
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Porphobilinogen deaminase (SMED30007511) t-SNE clustered cells

Violin plots show distribution of expression levels for Porphobilinogen deaminase (SMED30007511) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Porphobilinogen deaminase (SMED30007511) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Porphobilinogen deaminase (SMED30007511) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30007511

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pigment cellSMED30007511SMESG000025072.1 SmedASXL_004510SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult RNA-sequencing evidence
cephalic gangliaSMED30007511SMESG000025072.1 dd_Smed_v4_11623_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30007511SMESG000025072.1 dd_Smed_v4_11623_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pigment cellSMED30007511SMESG000025072.1 dd_Smed_v6_11623_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Porphobilinogen deaminase vs. Ensembl Human
Match: HMBS (hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982])

HSP 1 Score: 218.009 bits (554), Expect = 6.724e-67
Identity = 133/353 (37.68%), Postives = 199/353 (56.37%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIED--LSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V  LK+    L+++I+      +K+    L+ I +  L  K+L H AL  +E+D++VHS+KD+   L P F IG IC R++  D VV      GKTLE LP  SV+GTSSLRR ++L+RK+PH +   I+G+L+ R++KLD+QQ         +SA+ILA AG+ R+   +R+ Q L   +  YAVGQGAL  E R  D +  +L+ V++D +++L CI ER+FL+  +   S  VAV +   +    L   V S DGS  I++    T+    V ++  D PE++    GI    I +         +NLG ++A LL S  A  IL   R+
Sbjct:    2 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEH-ALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQE--------FSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH---VPAQHEDGPEDDPQLVGITARNIPR---GPQLAAQNLGISLANLLLSKGAKNILDVARQ 339          
BLAST of Porphobilinogen deaminase vs. Ensembl Human
Match: HMBS (hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982])

HSP 1 Score: 218.009 bits (554), Expect = 6.724e-67
Identity = 133/353 (37.68%), Postives = 199/353 (56.37%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIED--LSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V  LK+    L+++I+      +K+    L+ I +  L  K+L H AL  +E+D++VHS+KD+   L P F IG IC R++  D VV      GKTLE LP  SV+GTSSLRR ++L+RK+PH +   I+G+L+ R++KLD+QQ         +SA+ILA AG+ R+   +R+ Q L   +  YAVGQGAL  E R  D +  +L+ V++D +++L CI ER+FL+  +   S  VAV +   +    L   V S DGS  I++    T+    V ++  D PE++    GI    I +         +NLG ++A LL S  A  IL   R+
Sbjct:    2 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEH-ALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQE--------FSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH---VPAQHEDGPEDDPQLVGITARNIPR---GPQLAAQNLGISLANLLLSKGAKNILDVARQ 339          
BLAST of Porphobilinogen deaminase vs. Ensembl Human
Match: HMBS (hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982])

HSP 1 Score: 218.009 bits (554), Expect = 6.724e-67
Identity = 133/353 (37.68%), Postives = 199/353 (56.37%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIED--LSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V  LK+    L+++I+      +K+    L+ I +  L  K+L H AL  +E+D++VHS+KD+   L P F IG IC R++  D VV      GKTLE LP  SV+GTSSLRR ++L+RK+PH +   I+G+L+ R++KLD+QQ         +SA+ILA AG+ R+   +R+ Q L   +  YAVGQGAL  E R  D +  +L+ V++D +++L CI ER+FL+  +   S  VAV +   +    L   V S DGS  I++    T+    V ++  D PE++    GI    I +         +NLG ++A LL S  A  IL   R+
Sbjct:    2 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEH-ALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQE--------FSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH---VPAQHEDGPEDDPQLVGITARNIPR---GPQLAAQNLGISLANLLLSKGAKNILDVARQ 339          
BLAST of Porphobilinogen deaminase vs. Ensembl Human
Match: HMBS (hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982])

HSP 1 Score: 218.009 bits (554), Expect = 1.318e-66
Identity = 134/353 (37.96%), Postives = 199/353 (56.37%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLSY--KKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V  LK+    L+++I+      +K+    L+ I + S   K+L H AL  +E+D++VHS+KD+   L P F IG IC R++  D VV      GKTLE LP  SV+GTSSLRR ++L+RK+PH +   I+G+L+ R++KLD+QQ         +SA+ILA AG+ R+   +R+ Q L   +  YAVGQGAL  E R  D +  +L+ V++D +++L CI ER+FL+  +   S  VAV +   +    L   V S DGS  I++    T+    V ++  D PE++    GI    I +      Q   NLG ++A LL S  A  IL   R+
Sbjct:   19 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEH-ALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQE--------FSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH---VPAQHEDGPEDDPQLVGITARNIPRGPQLAAQ---NLGISLANLLLSKGAKNILDVARQ 356          
BLAST of Porphobilinogen deaminase vs. Ensembl Human
Match: HMBS (hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982])

HSP 1 Score: 212.231 bits (539), Expect = 1.012e-64
Identity = 134/353 (37.96%), Postives = 198/353 (56.09%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANI--EDLSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V  LK+    L+++I       +K+    L+ I  + L  K+L H AL  +E+D++VHS+KD+   L P F IG IC R++  D VV      GKTLE LP  SV+GTSSLRR ++L+RK+PH +   I+G+L+ R++KLD+QQ         +SA+ILA AG+ R+   +R+ Q L   +  YAVGQGAL  E R  D +  +L+ V++D +++L CI ER+FL+  +   S  VAV +   +    L   V S DGS  I++    T+    V ++  D PE++    GI    I +      Q   NLG ++A LL S  A  IL   R+
Sbjct:    2 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEI------RDKILDTALSKIGEKSLFTKELEH-ALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQE--------FSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH---VPAQHEDGPEDDPQLVGITARNIPRGPQLAAQ---NLGISLANLLLSKGAKNILDVARQ 333          
BLAST of Porphobilinogen deaminase vs. Ensembl Fly
Match: l(3)02640 (gene:FBgn0010786 transcript:FBtr0072679)

HSP 1 Score: 166.392 bits (420), Expect = 3.951e-45
Identity = 97/260 (37.31%), Postives = 145/260 (55.77%), Query Frame = 2
Query:   68 KKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQS 844
            +K  R+G+R S LAL QT  ++  L+      +++I T     +++    L  I + S + +    AL    +D +VHS+KD+   L     IG +  R+   D +V+R + +G T+  LP GSVIGTSSLRR ++++R YPH  +  I+G+L+ R+ KLD       A+   +S +ILA+AG++R+    RISQ L  TD  YAVGQGALA ECR +D +   +L  +    +    + ERSFLK      S  VAV S
Sbjct:    5 EKVIRVGSRKSELALIQTKHVIGRLQKLYPKQKFEIHTMSTFGDRVLNVSLPKIGEKSLFTRDLEDALRNGGVDFVVHSLKDLPTALPTGMAIGAVLEREDARDALVLRENFKGHTIASLPKGSVIGTSSLRRTAQIRRMYPHLTVCDIRGNLNTRLAKLD-------AADSKFSGIILAQAGLVRMGWMSRISQVLEPTDLLYAVGQGALAVECRANDDQVLAMLQKLMCLNTTCRILAERSFLKTLGGGCSAPVAVWS 257          
BLAST of Porphobilinogen deaminase vs. Ensembl Zebrafish
Match: hmbsb (hydroxymethylbilane synthase, b [Source:ZFIN;Acc:ZDB-GENE-050522-491])

HSP 1 Score: 193.356 bits (490), Expect = 2.058e-57
Identity = 128/351 (36.47%), Postives = 189/351 (53.85%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +VE LK    ++ ++I+      +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L   F IG +  R++  D VV+    +GK L+ L   SVIGTSSLRR ++LK+++PH +   I+G+L+ R++KLD+           +SA+ILA AG+ R+  E+RISQ L   D  YAVGQGALA E R  D +  E++SV+ND  + LSCI ER+FLK  +   S  VAV S    S   L   V S DGS  +++    +   +    E+  + E     GI      K+          LG ++  LL S  A  IL   R+
Sbjct:   16 RVIRVGTRKSQLARIQTDSVVEKLKELYPDVLFEIVAMSTTGDKILDTALSKIGEKSLFTKELENALEKNEVDLVVHSLKDLPTVLPGGFTIGAVLKRENPHDAVVLHPKNKGKRLDSLSNKSVIGTSSLRRAAQLKKRFPHLEFKDIRGNLNTRLKKLDENND--------FSAIILAAAGLKRMGWENRISQILGPEDCMYAVGQGALAVEVRARDLDILEMVSVLNDSDTALSCIAERAFLKHLEGGCSVPVAVHSEVKNSQLYLTGAVYSLDGSDSLKETMQTSFNPDTQAEEQEKVDEKVQRLGITAL---KVPEAAQDAAMKLGVDLGNLLLSKGAKEILTVARQ 355          
BLAST of Porphobilinogen deaminase vs. Ensembl Zebrafish
Match: hmbsb (hydroxymethylbilane synthase, b [Source:ZFIN;Acc:ZDB-GENE-050522-491])

HSP 1 Score: 184.111 bits (466), Expect = 9.276e-55
Identity = 107/259 (41.31%), Postives = 157/259 (60.62%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQS 844
            +  R+GTR S LA  QT+ +VE LK    ++ ++I+      +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L   F IG +  R++  D VV+    +GK L+ L   SVIGTSSLRR ++LK+++PH +   I+G+L+ R++KLD+           +SA+ILA AG+ R+  E+RISQ L   D  YAVGQGALA E R  D +  E++SV+ND  + LSCI ER+FLK  +   S  VAV S
Sbjct:   30 RVIRVGTRKSQLARIQTDSVVEKLKELYPDVLFEIVAMSTTGDKILDTALSKIGEKSLFTKELENALEKNEVDLVVHSLKDLPTVLPGGFTIGAVLKRENPHDAVVLHPKNKGKRLDSLSNKSVIGTSSLRRAAQLKKRFPHLEFKDIRGNLNTRLKKLDENND--------FSAIILAAAGLKRMGWENRISQILGPEDCMYAVGQGALAVEVRARDLDILEMVSVLNDSDTALSCIAERAFLKHLEGGCSVPVAVHS 280          
BLAST of Porphobilinogen deaminase vs. Ensembl Zebrafish
Match: hmbsa (hydroxymethylbilane synthase a [Source:ZFIN;Acc:ZDB-GENE-040426-1375])

HSP 1 Score: 177.563 bits (449), Expect = 2.049e-51
Identity = 129/353 (36.54%), Postives = 194/353 (54.96%), Query Frame = 2
Query:   65 SKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            + +  R+GTR S LA  QT+ +   LK    ++  +I+    I +K+    L+ I + S + K    AL  +E+DI+VHS+KD+   L P F IG I  R++  D VV+     G TL+ LP  SVIGTSSLRR ++LK+++P  +   I+G+L+ R++KLD++          Y+A+ILA AG+ R+  E RISQ L   D  YAVGQGALA E R  D +  E++SV++   ++L CI ER+FLK  +   S  VAV +    S   L   V S DG+ C+  + T+  C  L +++ N+  +     G+    I    L   +K   LG ++A +L +  A  IL   RK
Sbjct:   15 ASRVIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLFTKELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSLPEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKDD--------YAAIILAAAGLKRMGWESRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLRCISERAFLKQLEGGCSVPVAVHTEVKGSMLYLTGAVYSLDGADCL--KDTMQTCVEL-DNKVNESTQRSANVGVTACNISSSALEAAEK---LGLDLANVLLNKGAKDILTTARK 353          
BLAST of Porphobilinogen deaminase vs. Ensembl Zebrafish
Match: hmbsa (hydroxymethylbilane synthase a [Source:ZFIN;Acc:ZDB-GENE-040426-1375])

HSP 1 Score: 177.178 bits (448), Expect = 2.812e-51
Identity = 129/353 (36.54%), Postives = 194/353 (54.96%), Query Frame = 2
Query:   65 SKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            + +  R+GTR S LA  QT+ +   LK    ++  +I+    I +K+    L+ I + S + K    AL  +E+DI+VHS+KD+   L P F IG I  R++  D VV+     G TL+ LP  SVIGTSSLRR ++LK+++P  +   I+G+L+ R++KLD+        +  Y+A+ILA AG+ R+  E RISQ L   D  YAVGQGALA E R  D +  E++SV++   ++L CI ER+FLK  +   S  VAV +    S   L   V S DG+ C+  + T+  C  L +++ N+  +     G+    I    L   +K   LG ++A +L +  A  IL   RK
Sbjct:   18 ASRVIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLFTKELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSLPEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDE--------KDDYAAIILAAAGLKRMGWESRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLRCISERAFLKQLEGGCSVPVAVHTEVKGSMLYLTGAVYSLDGADCL--KDTMQTCVEL-DNKVNESTQRSANVGVTACNISSSALEAAEK---LGLDLANVLLNKGAKDILTTARK 356          
BLAST of Porphobilinogen deaminase vs. Ensembl Zebrafish
Match: hmbsb (hydroxymethylbilane synthase, b [Source:ZFIN;Acc:ZDB-GENE-050522-491])

HSP 1 Score: 150.214 bits (378), Expect = 1.606e-42
Identity = 88/218 (40.37%), Postives = 131/218 (60.09%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDD 721
            +  R+GTR S LA  QT+ +VE LK    ++ ++I+      +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L   F IG +  R++  D VV+    +GK L+ L   SVIGTSSLRR ++LK+++PH +   I+G+L+ R++KLD+           +SA+ILA AG+ R+  E+RISQ L   D  YAVGQGALA E R  D
Sbjct:   18 RVIRVGTRKSQLARIQTDSVVEKLKELYPDVLFEIVAMSTTGDKILDTALSKIGEKSLFTKELENALEKNEVDLVVHSLKDLPTVLPGGFTIGAVLKRENPHDAVVLHPKNKGKRLDSLSNKSVIGTSSLRRAAQLKKRFPHLEFKDIRGNLNTRLKKLDENND--------FSAIILAAAGLKRMGWENRISQILGPEDCMYAVGQGALAVEVRARD 227          
BLAST of Porphobilinogen deaminase vs. Ensembl Xenopus
Match: neurl1b (neuralized E3 ubiquitin protein ligase 1B [Source:Xenbase;Acc:XB-GENE-6469687])

HSP 1 Score: 208.764 bits (530), Expect = 2.767e-63
Identity = 130/353 (36.83%), Postives = 195/353 (55.24%), Query Frame = 2
Query:   65 SKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +K   R+GTR S LA  QT+ +VE+L  +  +  + I+      +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L P F IG +C R++  D VV      G TL  LP  SVIGTSSLRR ++LK+K+PH +   I+G+L+ R++KLD+++         +SA+ILA AG+ R+  E+RI Q L   +  YAVGQGALA E R  D +   ++S + D +++L CI ER+F+K  +   S  VAV +V  +S   L   V S DGS  +  ++T+  C N  + E     ++    GI   G+    L   + C  LG  +A LL S  A  IL   R+
Sbjct:    7 NKHVIRVGTRKSQLARIQTDSVVEMLSKRFPSTHFDIVAMSTTGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTSLPPGFTIGAVCKRENPYDAVVFHPKRYGNTLSTLPEKSVIGTSSLRRAAQLKKKFPHLEFKDIRGNLNTRMKKLDEKED--------FSAIILAAAGLRRMGWENRIGQILTSDECLYAVGQGALAIEVRAKDQDILSMVSALQDPETVLRCIAERAFMKRLEGGCSVPVAVNTVVKDSQLYLTGAVYSLDGSDSL--KETMQSCINFPQQEVEGPNDDVQHVGITALGVSHQALESAE-C--LGTGLADLLLSKGAKEILTVARQ 346          
BLAST of Porphobilinogen deaminase vs. Ensembl Xenopus
Match: neurl1b (neuralized E3 ubiquitin protein ligase 1B [Source:Xenbase;Acc:XB-GENE-6469687])

HSP 1 Score: 208.764 bits (530), Expect = 3.082e-63
Identity = 129/353 (36.54%), Postives = 194/353 (54.96%), Query Frame = 2
Query:   65 SKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +K   R+GTR S LA  QT+ +VE+L  +  +  + I+      +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L P F IG +C R++  D VV      G TL  LP  SVIGTSSLRR ++LK+K+PH +   I+G+L+ R++KLD+++         +SA+ILA AG+ R+  E+RI Q L   +  YAVGQGALA E R  D +   ++S + D +++L CI ER+F+K  +   S  VAV +V  +S   L   V S DGS  +  ++T+  C N  + E     ++    GI   G+    L   +    LG  +A LL S  A  IL   R+
Sbjct:   14 NKHVIRVGTRKSQLARIQTDSVVEMLSKRFPSTHFDIVAMSTTGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTSLPPGFTIGAVCKRENPYDAVVFHPKRYGNTLSTLPEKSVIGTSSLRRAAQLKKKFPHLEFKDIRGNLNTRMKKLDEKED--------FSAIILAAAGLRRMGWENRIGQILTSDECLYAVGQGALAIEVRAKDQDILSMVSALQDPETVLRCIAERAFMKRLEGGCSVPVAVNTVVKDSQLYLTGAVYSLDGSDSL--KETMQSCINFPQQEVEGPNDDVQHVGITALGVSHQAL---ESAECLGTGLADLLLSKGAKEILTVARQ 353          
BLAST of Porphobilinogen deaminase vs. Ensembl Xenopus
Match: neurl1b (neuralized E3 ubiquitin protein ligase 1B [Source:Xenbase;Acc:XB-GENE-6469687])

HSP 1 Score: 186.037 bits (471), Expect = 2.879e-55
Identity = 111/286 (38.81%), Postives = 162/286 (56.64%), Query Frame = 2
Query:  263 ALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            AL  +E+D++VHS+KD+   L P F IG +C R++  D VV      G TL  LP  SVIGTSSLRR ++LK+K+PH +   I+G+L+ R++KLD+++         +SA+ILA AG+ R+  E+RI Q L   +  YAVGQGALA E R  D +   ++S + D +++L CI ER+F+K  +   S  VAV +V  +S   L   V S DGS  +  ++T+  C N  + E     ++    GI   G+    L   + C  LG  +A LL S  A  IL   R+
Sbjct:   10 ALERNEVDLVVHSLKDLPTSLPPGFTIGAVCKRENPYDAVVFHPKRYGNTLSTLPEKSVIGTSSLRRAAQLKKKFPHLEFKDIRGNLNTRMKKLDEKED--------FSAIILAAAGLRRMGWENRIGQILTSDECLYAVGQGALAIEVRAKDQDILSMVSALQDPETVLRCIAERAFMKRLEGGCSVPVAVNTVVKDSQLYLTGAVYSLDGSDSL--KETMQSCINFPQQEVEGPNDDVQHVGITALGVSHQALESAE-C--LGTGLADLLLSKGAKEILTVARQ 282          
BLAST of Porphobilinogen deaminase vs. Ensembl Xenopus
Match: neurl1b (neuralized E3 ubiquitin protein ligase 1B [Source:Xenbase;Acc:XB-GENE-6469687])

HSP 1 Score: 186.037 bits (471), Expect = 3.426e-55
Identity = 111/286 (38.81%), Postives = 162/286 (56.64%), Query Frame = 2
Query:  263 ALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            AL  +E+D++VHS+KD+   L P F IG +C R++  D VV      G TL  LP  SVIGTSSLRR ++LK+K+PH +   I+G+L+ R++KLD+++         +SA+ILA AG+ R+  E+RI Q L   +  YAVGQGALA E R  D +   ++S + D +++L CI ER+F+K  +   S  VAV +V  +S   L   V S DGS  +  ++T+  C N  + E     ++    GI   G+    L   + C  LG  +A LL S  A  IL   R+
Sbjct:   15 ALERNEVDLVVHSLKDLPTSLPPGFTIGAVCKRENPYDAVVFHPKRYGNTLSTLPEKSVIGTSSLRRAAQLKKKFPHLEFKDIRGNLNTRMKKLDEKED--------FSAIILAAAGLRRMGWENRIGQILTSDECLYAVGQGALAIEVRAKDQDILSMVSALQDPETVLRCIAERAFMKRLEGGCSVPVAVNTVVKDSQLYLTGAVYSLDGSDSL--KETMQSCINFPQQEVEGPNDDVQHVGITALGVSHQALESAE-C--LGTGLADLLLSKGAKEILTVARQ 287          
BLAST of Porphobilinogen deaminase vs. Ensembl Xenopus
Match: neurl1b (neuralized E3 ubiquitin protein ligase 1B [Source:Xenbase;Acc:XB-GENE-6469687])

HSP 1 Score: 183.341 bits (464), Expect = 4.703e-54
Identity = 110/286 (38.46%), Postives = 159/286 (55.59%), Query Frame = 2
Query:  263 ALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            AL  +E+D++VHS+KD+   L P F IG +C R++  D VV      G TL  LP  SVIGTSSLRR ++LK+K+PH +   I+G+L+ R++KLD+++         +SA+ILA AG+ R+  E+RI Q L   +  YAVGQGALA E R  D +   ++S + D +++L CI ER+F+K  +   S  VAV +V  +S   L   V S DGS  +++     L    VE   +D+       GI   G+    L   +    LG  +A LL S  A  IL   R+
Sbjct:   29 ALERNEVDLVVHSLKDLPTSLPPGFTIGAVCKRENPYDAVVFHPKRYGNTLSTLPEKSVIGTSSLRRAAQLKKKFPHLEFKDIRGNLNTRMKKLDEKED--------FSAIILAAAGLRRMGWENRIGQILTSDECLYAVGQGALAIEVRAKDQDILSMVSALQDPETVLRCIAERAFMKRLEGGCSVPVAVNTVVKDSQLYLTGAVYSLDGSDSLKETMQRKLISLEVEGPNDDV----QHVGITALGVSHQAL---ESAECLGTGLADLLLSKGAKEILTVARQ 299          
BLAST of Porphobilinogen deaminase vs. Ensembl Mouse
Match: Hmbs (hydroxymethylbilane synthase [Source:MGI Symbol;Acc:MGI:96112])

HSP 1 Score: 209.92 bits (533), Expect = 6.744e-64
Identity = 129/352 (36.65%), Postives = 200/352 (56.82%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V +LK+    ++++I+      +K+    L+ I + S + K    AL  +E+D++VHS+KDV   L P F IG IC R++  D VV      GKTLE LP  S +GTSSLRR+++L+RK+PH +   I+G+L+ R++KLD+ Q         +SA++LA AG+ R+  ++R+ Q L   +  YAVGQGALA E R  D +  +L+SV++D +++L CI ER+FL+  +   S  VAV +V  +    L   V S DGS  +++    T+    V  ++ D PE++    GI    I +          NLG ++A LL +  A  IL   R+
Sbjct:    2 RVIRVGTRKSQLARIQTDTVVAMLKALYPGIQFEIIAMSTTGDKILDTALSKIGEKSLFTKELENALEKNEVDLVVHSLKDVPTILPPGFTIGAICKRENPCDAVVFHPKFIGKTLETLPEKSAVGTSSLRRVAQLQRKFPHLEFKSIRGNLNTRLRKLDELQE--------FSAIVLAVAGLQRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVSVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTVMKDGQLYLTGGVWSLDGSDSMQETMQATIQ---VPVQQEDGPEDDPQLVGITARNIPR---GAQLAAENLGISLASLLLNKGAKNILDVARQ 339          
BLAST of Porphobilinogen deaminase vs. Ensembl Mouse
Match: Hmbs (hydroxymethylbilane synthase [Source:MGI Symbol;Acc:MGI:96112])

HSP 1 Score: 210.305 bits (534), Expect = 8.823e-64
Identity = 129/352 (36.65%), Postives = 200/352 (56.82%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V +LK+    ++++I+      +K+    L+ I + S + K    AL  +E+D++VHS+KDV   L P F IG IC R++  D VV      GKTLE LP  S +GTSSLRR+++L+RK+PH +   I+G+L+ R++KLD+ Q         +SA++LA AG+ R+  ++R+ Q L   +  YAVGQGALA E R  D +  +L+SV++D +++L CI ER+FL+  +   S  VAV +V  +    L   V S DGS  +++    T+    V  ++ D PE++    GI    I +          NLG ++A LL +  A  IL   R+
Sbjct:   19 RVIRVGTRKSQLARIQTDTVVAMLKALYPGIQFEIIAMSTTGDKILDTALSKIGEKSLFTKELENALEKNEVDLVVHSLKDVPTILPPGFTIGAICKRENPCDAVVFHPKFIGKTLETLPEKSAVGTSSLRRVAQLQRKFPHLEFKSIRGNLNTRLRKLDELQE--------FSAIVLAVAGLQRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVSVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTVMKDGQLYLTGGVWSLDGSDSMQETMQATIQ---VPVQQEDGPEDDPQLVGITARNIPR---GAQLAAENLGISLASLLLNKGAKNILDVARQ 356          
BLAST of Porphobilinogen deaminase vs. Ensembl Mouse
Match: Hmbs (hydroxymethylbilane synthase [Source:MGI Symbol;Acc:MGI:96112])

HSP 1 Score: 82.8037 bits (203), Expect = 1.109e-18
Identity = 44/115 (38.26%), Postives = 69/115 (60.00%), Query Frame = 2
Query:  590 ALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTL 934
            A++LA AG+ R+  ++R+ Q L   +  YAVGQGALA E R  D +  +L+SV++D +++L CI ER+FL+  +   S  VAV +V  +    L   V S DGS  +++    T+
Sbjct:    2 AIVLAVAGLQRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVSVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTVMKDGQLYLTGGVWSLDGSDSMQETMQATI 116          
BLAST of Porphobilinogen deaminase vs. UniProt/SwissProt
Match: sp|P08397|HEM3_HUMAN (Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2)

HSP 1 Score: 218.009 bits (554), Expect = 6.328e-66
Identity = 134/353 (37.96%), Postives = 199/353 (56.37%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLSY--KKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V  LK+    L+++I+      +K+    L+ I + S   K+L H AL  +E+D++VHS+KD+   L P F IG IC R++  D VV      GKTLE LP  SV+GTSSLRR ++L+RK+PH +   I+G+L+ R++KLD+QQ         +SA+ILA AG+ R+   +R+ Q L   +  YAVGQGAL  E R  D +  +L+ V++D +++L CI ER+FL+  +   S  VAV +   +    L   V S DGS  I++    T+    V ++  D PE++    GI    I +      Q   NLG ++A LL S  A  IL   R+
Sbjct:   19 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEH-ALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQE--------FSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH---VPAQHEDGPEDDPQLVGITARNIPRGPQLAAQ---NLGISLANLLLSKGAKNILDVARQ 356          
BLAST of Porphobilinogen deaminase vs. UniProt/SwissProt
Match: sp|P22907|HEM3_MOUSE (Porphobilinogen deaminase OS=Mus musculus OX=10090 GN=Hmbs PE=1 SV=2)

HSP 1 Score: 210.305 bits (534), Expect = 6.172e-63
Identity = 129/352 (36.65%), Postives = 200/352 (56.82%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V +LK+    ++++I+      +K+    L+ I + S + K    AL  +E+D++VHS+KDV   L P F IG IC R++  D VV      GKTLE LP  S +GTSSLRR+++L+RK+PH +   I+G+L+ R++KLD+ Q         +SA++LA AG+ R+  ++R+ Q L   +  YAVGQGALA E R  D +  +L+SV++D +++L CI ER+FL+  +   S  VAV +V  +    L   V S DGS  +++    T+    V  ++ D PE++    GI    I +          NLG ++A LL +  A  IL   R+
Sbjct:   19 RVIRVGTRKSQLARIQTDTVVAMLKALYPGIQFEIIAMSTTGDKILDTALSKIGEKSLFTKELENALEKNEVDLVVHSLKDVPTILPPGFTIGAICKRENPCDAVVFHPKFIGKTLETLPEKSAVGTSSLRRVAQLQRKFPHLEFKSIRGNLNTRLRKLDELQE--------FSAIVLAVAGLQRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVSVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTVMKDGQLYLTGGVWSLDGSDSMQETMQATIQ---VPVQQEDGPEDDPQLVGITARNIPR---GAQLAAENLGISLASLLLNKGAKNILDVARQ 356          
BLAST of Porphobilinogen deaminase vs. UniProt/SwissProt
Match: sp|P19356|HEM3_RAT (Porphobilinogen deaminase OS=Rattus norvegicus OX=10116 GN=Hmbs PE=1 SV=2)

HSP 1 Score: 209.149 bits (531), Expect = 1.681e-62
Identity = 129/352 (36.65%), Postives = 199/352 (56.53%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V +LK+    ++++I+      +K+    L+ I + S + K    AL  +E+D++VHS+KDV   L P F IG IC R++  D VV      GKTLE LP  S +GTSSLRR+++L+RK+PH +   I+G+L+ R++KLD+Q          +SA+ILA AG+ R+  ++R+ Q L   +  YAVGQGALA E R  D +  +L+ V++D +++L CI ER+FL+  +   S  VAV +V  +    L   V S DGS  +++    T+    V  ++ D PE++    GI    I +          NLG ++A LL +  A  IL   R+
Sbjct:   19 RVIRVGTRKSQLARIQTDTVVAMLKTLYPGIQFEIIAMSTTGDKILDTALSKIGEKSLFTKELENALEKNEVDLVVHSLKDVPTILPPGFTIGAICKRENPCDAVVFHPKFIGKTLETLPEKSAVGTSSLRRVAQLQRKFPHLEFKSIRGNLNTRLRKLDEQLE--------FSAIILAVAGLQRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTVMKDGQLYLTGGVWSLDGSDSMQETMQATIQ---VPVQQEDGPEDDPQLVGITARNIPR---GAQLAAENLGISLASLLLNKGAKNILDVARQ 356          
BLAST of Porphobilinogen deaminase vs. UniProt/SwissProt
Match: sp|Q2KIN5|HEM3_BOVIN (Porphobilinogen deaminase OS=Bos taurus OX=9913 GN=HMBS PE=2 SV=1)

HSP 1 Score: 208.379 bits (529), Expect = 3.219e-62
Identity = 129/353 (36.54%), Postives = 197/353 (55.81%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIED--LSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENE-NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  R+GTR S LA  QT+ +V  LK+    L+++I+      +K+    L+ I +  L  K+L H AL  +E+D++VHS+KD+   L P F IG +C R+S  D VV      GKTLE LP  SV+GTSSLRR ++L+RK+PH +   I+G+L+ R++KLD+ Q         +SA+ILA AG+ R+  ++R+ Q L   +  YAVGQGAL  E R  D +  +L+ V++D +++L CI ERSFL+  +   S  VAV +   +    L   V S +G++ ++     T+    V  +  D PE++    GI    I +          NLG ++A LL +  A  IL   R+
Sbjct:   19 RVIRVGTRKSQLARIQTDSVVATLKALYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEH-ALERNEVDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFKSIRGNLNTRLRKLDELQE--------FSAIILATAGLQRMGWQNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERSFLRHLEGGCSVPVAVHTAIKDGQLYLTGGVWSLNGAETMQDTMQTTIH---VPVQHEDGPEDDPQLVGITARNIPR---QPQLAAENLGISLATLLLNKGAKNILDVARQ 356          
BLAST of Porphobilinogen deaminase vs. UniProt/SwissProt
Match: sp|Q31PM2|HEM3_SYNE7 (Porphobilinogen deaminase OS=Synechococcus elongatus (strain PCC 7942 / FACHB-805) OX=1140 GN=hemC PE=3 SV=1)

HSP 1 Score: 171.785 bits (434), Expect = 8.399e-49
Identity = 97/284 (34.15%), Postives = 153/284 (53.87%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKE 919
            +  RIG+R S LAL QT+ +   L+    + ++ + T     + +    LA I D   + K   +A+   E+D  VHS+KD+  +L    ++GC+  R+   D +V+    +   LE LP G+VIGTSSLRR+++L+  YPH     ++G+L+ R+ KLD  +         Y ALILA AG+ RL++  RI Q +    + +AVGQGAL  ECR +DPE  ELL  +  E +   C+ ER+FL+  +      + V +   +   TL   V+S DG + +  +
Sbjct:    7 RPIRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFTKELEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDRFKDHQLETLPEGTVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGE---------YDALILAAAGLQRLSMADRIHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEGGCQVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQ 281          
BLAST of Porphobilinogen deaminase vs. TrEMBL
Match: A0A2R4LGK7 (Porphobilinogen deaminase OS=Dugesia japonica OX=6161 GN=PBGD PE=2 SV=1)

HSP 1 Score: 273.092 bits (697), Expect = 1.280e-84
Identity = 150/364 (41.21%), Postives = 229/364 (62.91%), Query Frame = 2
Query:   68 KKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQ----TDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNL---VESEKNDLPENE--------NFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHE 1111
            K+  R+G+R+S LA+ QTN I++LL+ K+ ++E++++  + I + +    L  I + S + K   +AL   E+D +VHS+KDV   +S EF+IG + MR++C+D VV +++ + K+L  LP GS++GTSS+RR ++LK+K+P  + + I+G+L+ R+ KLDD +       G ++K Y A+ILAKAG+ RLN  +RIS+ L + DT YAVGQGALACECR +D ETR+LL+ INDE S+L+CI ER+FL   D   S  + V++   E+    + C+ S DGS  I  +  + L +      E+ KN    N+        NFTGI I+GID  T  K++ C  LG N+A  +     D IL+E
Sbjct:    7 KRIVRVGSRTSTLAVTQTNMIIDLLREKNNDVEFKLVIMDTIGDTILNMNLYKIGNSSLFTKELELALLADEVDFVVHSLKDVPTSISNEFIIGSVSMRETCDDAVVFKINSEYKSLSSLPNGSIVGTSSVRRTAQLKKKFPQLEFVSIRGNLNTRLLKLDDPEKAFKMRKGDNQK-YDAIILAKAGLERLNWAYRISETLSYDDTLYAVGQGALACECRYNDIETRKLLATINDEYSILTCIVERTFLHKLDGGCSTPIGVRTYLKENQLIFQGCLMSLDGSNTITNKIEIELPNTTKSSSEAPKNGHKSNQKMNGVSHLNFTGIDIYGIDSQTKIKIETCAILGVNLANSILFQGGDKILNE 369          
BLAST of Porphobilinogen deaminase vs. TrEMBL
Match: A0A4Y2CF70 (Porphobilinogen deaminase OS=Araneus ventricosus OX=182803 GN=Hmbs PE=3 SV=1)

HSP 1 Score: 227.639 bits (579), Expect = 4.797e-67
Identity = 145/348 (41.67%), Postives = 204/348 (58.62%), Query Frame = 2
Query:   77 FRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENR 1117
             RIG+R S LAL QTN + +LL+   + + Y I++   I +K+  K L+ I + S + K   IAL   E+ I+VHS+KD+   L    VI  IC R++  DVVV   +   K L+ELP GSVIGTSSLRRI++LKR +P+     I+G+L+ R +KLD+         K YSA+ILA AG+IRL+LEHRI+Q L   D  YAVGQGALA ECR  D  T +LLS I+ E++ L C+ ER+F+K  +   S  + V S       TL+  V S DGSK I +E T    D++ +S KN +   +++ GI+   +    L   +   +LG+ +A+ L    A  IL E R
Sbjct:   34 IRIGSRKSQLALFQTNFVADLLRKHYSGIAYDIVSMSTIGDKILDKALSKIGEKSLFTKELEIALEKEEVHIVVHSLKDLPTTLPDGMVIAAICERENPFDVVVFSSEHDYKNLKELPDGSVIGTSSLRRIAQLKRLFPNLQFESIRGNLNTRFRKLDED--------KIYSAIILAAAGVIRLDLEHRINQVLTPEDCMYAVGQGALAIECRGSDTSTIKLLSKISHEETTLCCVAERAFMKTLEGGCSVPIGVYSTLENKKLTLRGGVYSLDGSKSIIEEIT----DDIYDS-KNSITPQKHYVGIVAPHLPHHVLNAAE---SLGQKLAESLLQKGASDILKEAR 365          
BLAST of Porphobilinogen deaminase vs. TrEMBL
Match: A0A0P5YB44 (Porphobilinogen deaminase OS=Daphnia magna OX=35525 PE=3 SV=1)

HSP 1 Score: 220.32 bits (560), Expect = 2.635e-64
Identity = 136/373 (36.46%), Postives = 212/373 (56.84%), Query Frame = 2
Query:    8 FVTRIIYFLSIMFNLSSKFSKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRKE 1123
            FV   I+FL   F L  K +K T R+G+R S LAL Q+  ++ELL  +  +  + + T   I +++  + L+ I + S + +   +AL  +++D++VHS+KD+   L    VIG I  R+   D V+M       TL  LP GSV+GTSSLRR ++LKR +PH  I  I+G+L+ R++KLD++ T        Y+ALILA AG+ R+N E RIS+ L    + YA+GQGAL  ECR DD  TR+LL+  +  +++L C+ ER+FL+  +   S  VAV+S F +    LK  V S DG + I +   + L D       +D+P  +++T ++      L  +++     LG ++A  + +    IIL E +KE
Sbjct:    4 FVISDIFFLKERFFLG-KRAKTTIRVGSRKSQLALIQSKHVLELLTQRYEDKNFHLETMTTIGDEVLDRALSQIGEKSLFTRELEVALEHNKVDLVVHSLKDMPTSLPIGMVIGAILEREDPRDAVIMSPKFFECTLATLPTGSVVGTSSLRRAAQLKRHFPHLVIQDIRGNLNTRLRKLDEEGT--------YAALILATAGVKRMNWESRISEHLNTDVSMYAIGQGALGIECRQDDMATRQLLAPFSHAETLLCCVAERAFLRTLEGGCSAPVAVESRFLDDVLYLKGGVWSLDGKRSITQSLDVKLAD------IDDVPPAQSYTAVV---SSHLNNSRLALAEWLGVSLAGKIVALGGGIILDEAKKE 358          
BLAST of Porphobilinogen deaminase vs. TrEMBL
Match: A0A2L2Y8Y0 (Porphobilinogen deaminase (Fragment) OS=Parasteatoda tepidariorum OX=114398 PE=2 SV=1)

HSP 1 Score: 220.32 bits (560), Expect = 3.902e-64
Identity = 140/349 (40.11%), Postives = 205/349 (58.74%), Query Frame = 2
Query:   77 FRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESD-YTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENR 1117
             R+G+R S LAL Q+N +V+LL+ +  N+ Y I+      +K+    L+ I + S + K   IAL   E+D++VHS+KD+   L P  VIG IC R++  DVVV   D +   L++LP GS++GTSSLRRI++L R +P      I+G+L+ R++KLD+         K YSALI+A AG+IRL+LEHRI   L   +  YAVGQGALA ECR  D +T ELLS I+D+ + L CI ERSF+K+ +   S  +AV S   +++  TL   V S DGSK I +E    L  +L  ++       +++  I+      L+   + K  +LG+++A L     A+ IL E R
Sbjct:   39 IRVGSRKSQLALFQSNFVVDLLRKQYKNIAYDIVPMSTTGDKILNVALSKIGEKSLFTKELEIALEKREVDVVVHSLKDLPTTLPPGMVIGAICQRENPFDVVVFSPDCKCSHLKDLPKGSIVGTSSLRRIAQLGRVFPQLTFESIRGNLNTRLRKLDED--------KNYSALIIAAAGLIRLDLEHRIGMILKPEECMYAVGQGALAIECRESDVQTIELLSQISDKNTTLRCIAERSFMKSLEGGCSVPIAVNSSIDKNEKLTLCGGVFSLDGSKSIIEE----LSVDLKPTKPFQFQVKKHYAAIV---APHLSHNILSKAESLGKDLADLFLEKGAEAILKEAR 372          
BLAST of Porphobilinogen deaminase vs. TrEMBL
Match: A0A087TRQ7 (Porphobilinogen deaminase (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_26221 PE=3 SV=1)

HSP 1 Score: 219.55 bits (558), Expect = 4.543e-64
Identity = 140/364 (38.46%), Postives = 213/364 (58.52%), Query Frame = 2
Query:   47 NLSSKFSKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRKEKKCS 1135
            N+ +  +K   R+G+R S LAL Q+N +V+LLK    +++Y I+T     +K+    L+ I + S + K   +AL   E+D+IVHS+KD+   L P  VIG IC R++  DV V       K L+ LP GSVIGTSSLRR+++L++ YP+     ++G+L+ R++KLD+ +T        +SALILA AG+IRL+L +RI Q     +  YAVGQGALA EC+ DD ET +L+S I+D+ + L CI ERSF+K  +   S  VAV S       TL+  V S DG K I ++ ++      +E     +P+ +++ G++   + +  L   +   +LG  +A+LL S  A  IL E R + + S
Sbjct:   22 NVINGSTKARIRVGSRKSQLALFQSNFVVDLLKENYGSIKYDIITMTTTGDKILDVALSKIGEKSLFTKELEVALEKQEVDVIVHSLKDLPTSLPPGMVIGAICKRENPFDVAVFPPGSNCKDLKSLPPGSVIGTSSLRRVAQLRKMYPNLAFQSVRGNLNTRLRKLDEDKT--------FSALILAAAGLIRLDLSNRIDQTFTPEECMYAVGQGALAIECQEDDLETIQLISKISDKDTTLCCIAERSFMKTLEGGCSVPVAVYSKIEGKKLTLQGGVFSLDGCKSIIEKISMD-----IEHADKCVPK-QHYAGVVAPHLPQYCLCNAE---HLGMELAELLLSKGALDILKEARAKNESS 368          
BLAST of Porphobilinogen deaminase vs. Ensembl Cavefish
Match: hmbsb (porphobilinogen deaminase-like [Source:NCBI gene;Acc:103033329])

HSP 1 Score: 195.667 bits (496), Expect = 8.292e-58
Identity = 135/376 (35.90%), Postives = 202/376 (53.72%), Query Frame = 2
Query:   20 IIYFLSIMFNLSSKFSK-------KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTL-CDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            II+++  M +   K+++       +  RIGTR S LA  QT+ + E LK    ++  +I+      +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L   F IG +  R+S  D VV+     GK+L+ LP  SVIGTSSLRR ++LK+++PH +   I+G+L+ R++KLD+           +SA+ILA AG+ R+  + RISQ L   D  YAVGQGALA E R  D +  E++SV++D  ++L CI ER+FL+  +   S  VAV +    S   L   V S DGS  ++     T+  DN  E EK D  E     G+      K++         LG ++A LL S  A  IL   R+
Sbjct:   37 IIHYIKTMADGPYKYARDEEGKVSRVIRIGTRKSQLARIQTDSVAEKLKELYPDVLLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTILPVGFTIGAVLKRESPYDAVVLHPKNAGKSLDLLPNKSVIGTSSLRRAAQLKKRFPHLEFKDIRGNLNTRLKKLDENSD--------FSAIILAAAGLRRMGWDSRISQILGPEDCMYAVGQGALAIEVRASDQDILEMVSVLHDPDTVLRCIAERAFLRHLEGGCSVPVAVHTEVKNSQLYLTGAVYSLDGSDSLKDTMQTTVSSDNQEEQEKVD--EKVQRVGVTAL---KVSGAAQDAAEKLGVDLANLLLSKGAKEILTVARQ 399          
BLAST of Porphobilinogen deaminase vs. Ensembl Cavefish
Match: hmbsb (porphobilinogen deaminase-like [Source:NCBI gene;Acc:103033329])

HSP 1 Score: 195.667 bits (496), Expect = 8.292e-58
Identity = 135/376 (35.90%), Postives = 202/376 (53.72%), Query Frame = 2
Query:   20 IIYFLSIMFNLSSKFSK-------KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTL-CDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            II+++  M +   K+++       +  RIGTR S LA  QT+ + E LK    ++  +I+      +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L   F IG +  R+S  D VV+     GK+L+ LP  SVIGTSSLRR ++LK+++PH +   I+G+L+ R++KLD+           +SA+ILA AG+ R+  + RISQ L   D  YAVGQGALA E R  D +  E++SV++D  ++L CI ER+FL+  +   S  VAV +    S   L   V S DGS  ++     T+  DN  E EK D  E     G+      K++         LG ++A LL S  A  IL   R+
Sbjct:   37 IIHYIKTMADGPYKYARDEEGKVSRVIRIGTRKSQLARIQTDSVAEKLKELYPDVLLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTILPVGFTIGAVLKRESPYDAVVLHPKNAGKSLDLLPNKSVIGTSSLRRAAQLKKRFPHLEFKDIRGNLNTRLKKLDENSD--------FSAIILAAAGLRRMGWDSRISQILGPEDCMYAVGQGALAIEVRASDQDILEMVSVLHDPDTVLRCIAERAFLRHLEGGCSVPVAVHTEVKNSQLYLTGAVYSLDGSDSLKDTMQTTVSSDNQEEQEKVD--EKVQRVGVTAL---KVSGAAQDAAEKLGVDLANLLLSKGAKEILTVARQ 399          
BLAST of Porphobilinogen deaminase vs. Ensembl Cavefish
Match: hmbsb (porphobilinogen deaminase-like [Source:NCBI gene;Acc:103033329])

HSP 1 Score: 191.43 bits (485), Expect = 1.242e-56
Identity = 131/352 (37.22%), Postives = 191/352 (54.26%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTL-CDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  RIGTR S LA  QT+ + E LK    ++  +I+      +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L   F IG +  R+S  D VV+     GK+L+ LP  SVIGTSSLRR ++LK+++PH +   I+G+L+ R++KLD+           +SA+ILA AG+ R+  + RISQ L   D  YAVGQGALA E R  D +  E++SV++D  ++L CI ER+FL+  +   S  VAV +    S   L   V S DGS  ++     T+  DN  E EK D  E     G+      K++         LG ++A LL S  A  IL   R+
Sbjct:   22 RVIRIGTRKSQLARIQTDSVAEKLKELYPDVLLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTILPVGFTIGAVLKRESPYDAVVLHPKNAGKSLDLLPNKSVIGTSSLRRAAQLKKRFPHLEFKDIRGNLNTRLKKLDENSD--------FSAIILAAAGLRRMGWDSRISQILGPEDCMYAVGQGALAIEVRASDQDILEMVSVLHDPDTVLRCIAERAFLRHLEGGCSVPVAVHTEVKNSQLYLTGAVYSLDGSDSLKDTMQTTVSSDNQEEQEKVD--EKVQRVGVTAL---KVSGAAQDAAEKLGVDLANLLLSKGAKEILTVARQ 360          
BLAST of Porphobilinogen deaminase vs. Ensembl Cavefish
Match: hmbsa (hydroxymethylbilane synthase [Source:NCBI gene;Acc:103032521])

HSP 1 Score: 175.252 bits (443), Expect = 1.409e-50
Identity = 111/282 (39.36%), Postives = 169/282 (59.93%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIE 913
            +  R+GTR S LA  QT+ + E LK   A+L+ +I+    I +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L P F IG +  R++  D VV+     G TL+ LP  SVIGTSSLRR ++LK+++P  +   I+G+L+ R++KLD+++         ++A+ILA AG+ R+  E RISQ L   D  YAVGQGALA E R  D +  E++S+++   ++L CI ER+FLK  +   S  VAV +   +S   L   V S DG+ C++
Sbjct:   17 RVIRMGTRKSQLARIQTDSVAEKLKELYADLQLEIVAMSTIGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTSLPPGFTIGAVLERENPHDAVVLHPKNAGLTLDSLPEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKED--------FAAIILAAAGLKRMGWESRISQVLGPEDCMYAVGQGALAIEVRARDRDILEMVSILHHPDTVLRCIAERAFLKQLEGGCSVPVAVYTEVKDSVLYLTGAVYSLDGADCLK 290          
BLAST of Porphobilinogen deaminase vs. Ensembl Cavefish
Match: hmbsb (porphobilinogen deaminase-like [Source:NCBI gene;Acc:103033329])

HSP 1 Score: 174.481 bits (441), Expect = 1.685e-50
Identity = 128/351 (36.47%), Postives = 185/351 (52.71%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTL-CDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  RIGTR S LA  QT+ + E LK    ++ +  L P + T K +  EL N            AL  +E+D++VHS+KD+   L   F IG +  R+S  D VV+     GK+L+ LP  SVIGTSSLRR ++LK+++PH +   I+G+L+ R++KLD+           +SA+ILA AG+ R+  + RISQ L   D  YAVGQGALA E R  D +  E++SV++D  ++L CI ER+FL+    R    +      T + Y+L       DGS  ++     T+  DN  E EK D  E     G+      K++         LG ++A LL S  A  IL   R+
Sbjct:   18 RVIRIGTRKSQLARIQTDSVAEKLKELYPDVLF--LFPTSPTFK-SFSELEN------------ALERNEVDLVVHSLKDLPTILPVGFTIGAVLKRESPYDAVVLHPKNAGKSLDLLPNKSVIGTSSLRRAAQLKKRFPHLEFKDIRGNLNTRLKKLDENSD--------FSAIILAAAGLRRMGWDSRISQILGPEDCMYAVGQGALAIEVRASDQDILEMVSVLHDPDTVLRCIAERAFLRHL-VRILLFLLKYLYLTGAVYSL-------DGSDSLKDTMQTTVSSDNQEEQEKVD--EKVQRVGVTAL---KVSGAAQDAAEKLGVDLANLLLSKGAKEILTVARQ 332          
BLAST of Porphobilinogen deaminase vs. Ensembl Sea Lamprey
Match: hmbsa (hydroxymethylbilane synthase a [Source:ZFIN;Acc:ZDB-GENE-040426-1375])

HSP 1 Score: 170.244 bits (430), Expect = 4.019e-51
Identity = 89/218 (40.83%), Postives = 132/218 (60.55%), Query Frame = 2
Query:  281 LDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTL 934
            +D++VHS+KD+   L P F +G I  R++ +D +V+   L G TLE LP  SVIGTSSLRR ++LKR +PH     ++G+L+ R++KLD+           YSAL+LA AG+ R+  + RISQ +      YAVGQGALA E R +D    ELLS ++   ++L C+ ER+FL+  +   S  VAV S     + +L   V S DG+ C++  + ++L
Sbjct:    1 VDLVVHSLKDLPTTLPPGFTVGAILQRENPQDALVLTPQLAGHTLESLPDKSVIGTSSLRRAAQLKRNFPHLAFKDVRGNLNTRLRKLDELGE--------YSALVLAAAGLSRMGWDDRISQIIDPGVCLYAVGQGALAVEVRAEDRHVLELLSFLHHRDTVLRCVAERAFLRTLEGGCSVPVAVHSHMEGKELSLTGAVYSLDGADCLKDTQKVSL 210          
BLAST of Porphobilinogen deaminase vs. Ensembl Yeast
Match: HEM3 (Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid [Source:SGD;Acc:S000002364])

HSP 1 Score: 166.392 bits (420), Expect = 1.756e-48
Identity = 103/312 (33.01%), Postives = 170/312 (54.49%), Query Frame = 2
Query:   62 FSKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLSYKKLSHIALNLH--------ELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTES--DYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKND 967
               +T  IG R S LA+ Q+N +++L++ K  + + ++ T + + +++  K L +      K L    L  H        +LD+IVHS+KD+   L   F +G I  R    D +VM      K+L++LP G ++GTSS+RR ++LKRKYPH     ++G++  R+QKLDD ++       PY  +ILA AG++R+ LE+RI+Q       ++AVGQGAL  E R  D +  ++L  I D  + + C+ ER+ ++  +   S  + V+S + E      LKA V   +G++ +E E      + L+E+ K D
Sbjct:    1 MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYS---FGGKALWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKS-------PYQCIILASAGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDE-----IEMLIENVKED 297          
BLAST of Porphobilinogen deaminase vs. Ensembl Medaka
Match: hmbsb (hydroxymethylbilane synthase [Source:NCBI gene;Acc:101164176])

HSP 1 Score: 178.718 bits (452), Expect = 6.003e-52
Identity = 126/351 (35.90%), Postives = 192/351 (54.70%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  RIGTR S LA  QT+ +   L+    ++  +I+    I +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L   F IG +  R++  D VV+     GKTL  LP  SV+GTSSLRR ++LKR++PH +   I+G+L+ R++KLDD++         ++A+ILA AG+ R+  E RIS  L   D  YAVGQGALA E R  D +  +++SV++D  ++L CI ER+FLK  +   S  VAV +   +S   L   V S DGS+ +++    ++C     SE+ D  E     G+      K+          LG ++A LL +  A  IL   R+
Sbjct:   18 RVIRIGTRKSQLARIQTDSVAAKLQELYPDVRLEIVAMSTIGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTSLPAGFTIGAVLRRENPHDAVVLHPKNAGKTLASLPKNSVVGTSSLRRAAQLKRRFPHLEFKDIRGNLNTRLKKLDDKED--------FAAIILAAAGLKRMGWEDRISAVLQPEDCMYAVGQGALAVEVRAKDTDILDMVSVLHDPDTVLRCIAERAFLKRLEGGCSVPVAVHTYIKDSQLYLTGAVYSLDGSESLKETMQTSICSGGSCSEEVD--ERLQRVGVTAT---KIPADLQDGAERLGVDLADLLLTKGAKEILTVARQ 355          
BLAST of Porphobilinogen deaminase vs. Ensembl Medaka
Match: hmbsb (hydroxymethylbilane synthase [Source:NCBI gene;Acc:101164176])

HSP 1 Score: 178.718 bits (452), Expect = 6.003e-52
Identity = 126/351 (35.90%), Postives = 192/351 (54.70%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  RIGTR S LA  QT+ +   L+    ++  +I+    I +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L   F IG +  R++  D VV+     GKTL  LP  SV+GTSSLRR ++LKR++PH +   I+G+L+ R++KLDD++         ++A+ILA AG+ R+  E RIS  L   D  YAVGQGALA E R  D +  +++SV++D  ++L CI ER+FLK  +   S  VAV +   +S   L   V S DGS+ +++    ++C     SE+ D  E     G+      K+          LG ++A LL +  A  IL   R+
Sbjct:   18 RVIRIGTRKSQLARIQTDSVAAKLQELYPDVRLEIVAMSTIGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTSLPAGFTIGAVLRRENPHDAVVLHPKNAGKTLASLPKNSVVGTSSLRRAAQLKRRFPHLEFKDIRGNLNTRLKKLDDKED--------FAAIILAAAGLKRMGWEDRISAVLQPEDCMYAVGQGALAVEVRAKDTDILDMVSVLHDPDTVLRCIAERAFLKRLEGGCSVPVAVHTYIKDSQLYLTGAVYSLDGSESLKETMQTSICSGGSCSEEVD--ERLQRVGVTAT---KIPADLQDGAERLGVDLADLLLTKGAKEILTVARQ 355          
BLAST of Porphobilinogen deaminase vs. Ensembl Medaka
Match: hmbsb (hydroxymethylbilane synthase [Source:NCBI gene;Acc:101164176])

HSP 1 Score: 178.718 bits (452), Expect = 6.688e-52
Identity = 126/351 (35.90%), Postives = 192/351 (54.70%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRK 1120
            +  RIGTR S LA  QT+ +   L+    ++  +I+    I +K+    L+ I + S + K    AL  +E+D++VHS+KD+   L   F IG +  R++  D VV+     GKTL  LP  SV+GTSSLRR ++LKR++PH +   I+G+L+ R++KLDD++         ++A+ILA AG+ R+  E RIS  L   D  YAVGQGALA E R  D +  +++SV++D  ++L CI ER+FLK  +   S  VAV +   +S   L   V S DGS+ +++    ++C     SE+ D  E     G+      K+          LG ++A LL +  A  IL   R+
Sbjct:   16 RVIRIGTRKSQLARIQTDSVAAKLQELYPDVRLEIVAMSTIGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTSLPAGFTIGAVLRRENPHDAVVLHPKNAGKTLASLPKNSVVGTSSLRRAAQLKRRFPHLEFKDIRGNLNTRLKKLDDKED--------FAAIILAAAGLKRMGWEDRISAVLQPEDCMYAVGQGALAVEVRAKDTDILDMVSVLHDPDTVLRCIAERAFLKRLEGGCSVPVAVHTYIKDSQLYLTGAVYSLDGSESLKETMQTSICSGGSCSEEVD--ERLQRVGVTAT---KIPADLQDGAERLGVDLADLLLTKGAKEILTVARQ 353          
BLAST of Porphobilinogen deaminase vs. Ensembl Medaka
Match: hmbsb (hydroxymethylbilane synthase [Source:NCBI gene;Acc:101164176])

HSP 1 Score: 166.777 bits (421), Expect = 1.815e-47
Identity = 107/282 (37.94%), Postives = 160/282 (56.74%), Query Frame = 2
Query:   71 KTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEK 916
            +  RIGTR S LA  QT+ +   L+    ++  +I   E          L+      + K    AL  +E+D++VHS+KD+   L   F IG +  R++  D VV+     GKTL  LP  SV+GTSSLRR ++LKR++PH +   I+G+L+ R++KLDD++         ++A+ILA AG+ R+  E RIS  L   D  YAVGQGALA E R  D +  +++SV++D  ++L CI ER+FLK  +   S  VAV +   +S   L   V S DGS+ +++
Sbjct:   18 RVIRIGTRKSQLARIQTDSVAAKLQELYPDVRLEI--GETFRLGFCQTTLSTCNKSLFTKELENALERNEVDLVVHSLKDLPTSLPAGFTIGAVLRRENPHDAVVLHPKNAGKTLASLPKNSVVGTSSLRRAAQLKRRFPHLEFKDIRGNLNTRLKKLDDKED--------FAAIILAAAGLKRMGWEDRISAVLQPEDCMYAVGQGALAVEVRAKDTDILDMVSVLHDPDTVLRCIAERAFLKRLEGGCSVPVAVHTYIKDSQLYLTGAVYSLDGSESLKE 289          
BLAST of Porphobilinogen deaminase vs. Planmine SMEST
Match: SMESG000025072.1 (SMESG000025072.1)

HSP 1 Score: 775.007 bits (2000), Expect = 0.000e+0
Identity = 380/381 (99.74%), Postives = 381/381 (100.00%), Query Frame = 2
Query:    2 NDFVTRIIYFLSIMFNLSSKFSKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHENRKEKKCSKHK 1144
            NDFVTRIIYFLSIMFNLSSKFSKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIIL+ENRKEKKCSKHK
Sbjct:    4 NDFVTRIIYFLSIMFNLSSKFSKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLSYKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILNENRKEKKCSKHK 384          
BLAST of Porphobilinogen deaminase vs. Planmine SMEST
Match: SMESG000024741.1 (SMESG000024741.1)

HSP 1 Score: 277.33 bits (708), Expect = 1.023e-89
Identity = 153/370 (41.35%), Postives = 243/370 (65.68%), Query Frame = 2
Query:   50 LSSKFSKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQ----QTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCI---------EKEKTL--TLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHE 1111
            + S+ +K+  R+G+R+S LA+ QT+ I++LLK+K+ ++E++++T + + +K+   +L  I D + + K   +AL  +E+D +VHS+KDV   +S +FVIG I +R+SC+D VV++++ + K LE LP GSVIGTSS+RRIS+LKRKYPH     I+G+L+ R+ KLDD     Q + G ++K Y A+ILAKAG+ RL   HRIS+ L + DTFYAVGQGALACECR +D E R++L+ INDE SML+C+ ER+F+   +   S  + V+S F E+ + LK C+ + +GS+ +         E EK L  +L +   ++   +   +  +TGI I+G++ +  ++++ C  LG  +A     +  D IL+E
Sbjct:    1 MESELTKRIVRVGSRTSLLAMTQTHMIIDLLKNKNPDIEFRLITMDTMGDKILNTKLYQIGDTALFTKELELALLENEVDFVVHSLKDVPTIMSKQFVIGSISLRESCDDAVVLKLNSKYKNLESLPEGSVIGTSSVRRISQLKRKYPHLKFSSIRGNLNTRLLKLDDPEKAFQMNKGDNQK-YEAIILAKAGLERLTWNHRISEVLSYEDTFYAVGQGALACECRRNDIEMRKILATINDEHSMLTCMAERAFMHELEGGCSTPIGVRSTFKENKFILKGCLLNLEGSESVFVKDEIDLPEYEKRLVQSLTNGHNKTSMINGDSDTTYTGIEIYGLNPVAYSRIKACIKLGLQLATNTLLNGGDKILNE 369          
BLAST of Porphobilinogen deaminase vs. Planmine SMEST
Match: SMESG000071507.1 (SMESG000071507.1)

HSP 1 Score: 265.388 bits (677), Expect = 3.494e-85
Identity = 148/363 (40.77%), Postives = 226/363 (62.26%), Query Frame = 2
Query:   68 KKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQ----QTDPGASRKPYSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGSKCIEKEKTLTLCD----------NLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIILHE 1111
            K+  ++G+R S LA  QT  +++LL++++ ++E+Q++T + I +KL   +L+   D S + K   +AL  +E+D +VHS+KDV   +S +FVIG I  R+SC+D VV+R++ + + LE LP GS+IGTSS RRI++LKRKYPH     ++G+L  R+ KLDD     Q + G ++K + A+ILAKAG+ RL  +HRIS+ L + DTFYAVGQGALACECR +D + R+LL+ INDE SML+CI ERSF+       S    V+S   E+   L+ C+ + +G++ +  +  + L +          N +++   D      FTG+ I+GI  L  +KM+ C  LG  +A  +     D IL E
Sbjct:    7 KRIVKVGSRMSLLAKTQTQMVIDLLENRNPDMEFQLVTMDKIGDKLLNLKLSQTVDTSLFTKELELALMANEVDFVVHSLKDVPTVISKQFVIGSISARESCDDAVVLRLNSEYQNLESLPEGSMIGTSSARRIAQLKRKYPHLKFSSMRGNLTTRLMKLDDPEKAFQMNKGDNQK-FEAIILAKAGLERLAWDHRISEVLSYEDTFYAVGQGALACECRRNDIDIRKLLADINDETSMLTCIAERSFICELKVGYSAPFGVRSTLKENRLVLQGCLLNGEGTESVIVKSEIDLVEKSNQFLSKTCNRMQAANGD--SGVRFTGVEIYGIGSLAYSKMEACVELGLQMAANILLGGGDKILKE 366          
BLAST of Porphobilinogen deaminase vs. Planmine SMEST
Match: SMESG000024670.1 (SMESG000024670.1)

HSP 1 Score: 245.743 bits (626), Expect = 5.107e-77
Identity = 155/388 (39.95%), Postives = 224/388 (57.73%), Query Frame = 2
Query:   65 SKKTFRIGTRSSPLALAQTNRIVELLKSKDANLEYQILTPENITEKLTMKELANIEDLS-YKKLSHIALNLHELDIIVHSMKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTSSLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTD--PGASRKP-YSALILAKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVINDEKSMLSCIGERSFLKAFDCRASEAVAVQS-VFTESDYTLKACVSSNDGSKCIEKEKTLTLCDNLV------------ESEKNDLPE------------------------NENFTGILIWGIDKLTLTKMQKCRNLGENVAKLLKSSDADIIL 1105
            +++T RIG+R+S LAL QT+ I+ LL    + ++++++T + I + +  KEL+ I D S + K   +AL   E+D +VHS+KDV   LS EFVIGCIC+R+S ED VVM+ +   KTLEELP  SV+GTSS+RRI++LK +Y H     ++G+L+ R++KLD    +   G    P YSALILAKAG+ R+ L  RISQ L    + YAVGQGALACECR DD  T +LLS I+D++S ++ I ERS ++  D   S  +AV+S V  +   TL+A V + DG++CI  E T  L +  +            E+E N  P                         N  F G  ++ I ++   +M   + LG  VA+ L ++ A  IL
Sbjct:    9 NRRTIRIGSRTSELALKQTHLIMNLLSKAHSEIDFKVVTMDTIGDIILDKELSKIGDKSLFTKELELALMAKEVDFVVHSLKDVPTALSDEFVIGCICLRESPEDAVVMKKNSIYKTLEELPTDSVVGTSSVRRIAQLKNRYSHLKFSSVRGNLNTRLKKLDAISIEEISGTGDVPSYSALILAKAGLERIGLSFRISQVLSHEGSLYAVGQGALACECRADDLSTLKLLSSIHDDESGITSIAERSLMRYLDGGCSTPIAVRSKVNKDGSLTLRAAVMNTDGTECISDEMTTRLPEEHIQEFLEKINSSESETEDNCPPSKKMKTNQSNYGEITEKEILLGKDPNSIFLGTRVFPICEIGRMRMAISQRLGAEVARRLLAAGAKQIL 396          
The following BLAST results are available for this feature:
BLAST of Porphobilinogen deaminase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HMBS6.724e-6737.68hydroxymethylbilane synthase [Source:HGNC Symbol;A... [more]
HMBS6.724e-6737.68hydroxymethylbilane synthase [Source:HGNC Symbol;A... [more]
HMBS6.724e-6737.68hydroxymethylbilane synthase [Source:HGNC Symbol;A... [more]
HMBS1.318e-6637.96hydroxymethylbilane synthase [Source:HGNC Symbol;A... [more]
HMBS1.012e-6437.96hydroxymethylbilane synthase [Source:HGNC Symbol;A... [more]
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BLAST of Porphobilinogen deaminase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Porphobilinogen deaminase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
l(3)026403.951e-4537.31gene:FBgn0010786 transcript:FBtr0072679[more]
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BLAST of Porphobilinogen deaminase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hmbsb2.058e-5736.47hydroxymethylbilane synthase, b [Source:ZFIN;Acc:Z... [more]
hmbsb9.276e-5541.31hydroxymethylbilane synthase, b [Source:ZFIN;Acc:Z... [more]
hmbsa2.049e-5136.54hydroxymethylbilane synthase a [Source:ZFIN;Acc:ZD... [more]
hmbsa2.812e-5136.54hydroxymethylbilane synthase a [Source:ZFIN;Acc:ZD... [more]
hmbsb1.606e-4240.37hydroxymethylbilane synthase, b [Source:ZFIN;Acc:Z... [more]
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BLAST of Porphobilinogen deaminase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
neurl1b2.767e-6336.83neuralized E3 ubiquitin protein ligase 1B [Source:... [more]
neurl1b3.082e-6336.54neuralized E3 ubiquitin protein ligase 1B [Source:... [more]
neurl1b2.879e-5538.81neuralized E3 ubiquitin protein ligase 1B [Source:... [more]
neurl1b3.426e-5538.81neuralized E3 ubiquitin protein ligase 1B [Source:... [more]
neurl1b4.703e-5438.46neuralized E3 ubiquitin protein ligase 1B [Source:... [more]
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BLAST of Porphobilinogen deaminase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Hmbs6.744e-6436.65hydroxymethylbilane synthase [Source:MGI Symbol;Ac... [more]
Hmbs8.823e-6436.65hydroxymethylbilane synthase [Source:MGI Symbol;Ac... [more]
Hmbs1.109e-1838.26hydroxymethylbilane synthase [Source:MGI Symbol;Ac... [more]
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BLAST of Porphobilinogen deaminase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P08397|HEM3_HUMAN6.328e-6637.96Porphobilinogen deaminase OS=Homo sapiens OX=9606 ... [more]
sp|P22907|HEM3_MOUSE6.172e-6336.65Porphobilinogen deaminase OS=Mus musculus OX=10090... [more]
sp|P19356|HEM3_RAT1.681e-6236.65Porphobilinogen deaminase OS=Rattus norvegicus OX=... [more]
sp|Q2KIN5|HEM3_BOVIN3.219e-6236.54Porphobilinogen deaminase OS=Bos taurus OX=9913 GN... [more]
sp|Q31PM2|HEM3_SYNE78.399e-4934.15Porphobilinogen deaminase OS=Synechococcus elongat... [more]
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BLAST of Porphobilinogen deaminase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2R4LGK71.280e-8441.21Porphobilinogen deaminase OS=Dugesia japonica OX=6... [more]
A0A4Y2CF704.797e-6741.67Porphobilinogen deaminase OS=Araneus ventricosus O... [more]
A0A0P5YB442.635e-6436.46Porphobilinogen deaminase OS=Daphnia magna OX=3552... [more]
A0A2L2Y8Y03.902e-6440.11Porphobilinogen deaminase (Fragment) OS=Parasteato... [more]
A0A087TRQ74.543e-6438.46Porphobilinogen deaminase (Fragment) OS=Stegodyphu... [more]
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BLAST of Porphobilinogen deaminase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hmbsb8.292e-5835.90porphobilinogen deaminase-like [Source:NCBI gene;A... [more]
hmbsb8.292e-5835.90porphobilinogen deaminase-like [Source:NCBI gene;A... [more]
hmbsb1.242e-5637.22porphobilinogen deaminase-like [Source:NCBI gene;A... [more]
hmbsa1.409e-5039.36hydroxymethylbilane synthase [Source:NCBI gene;Acc... [more]
hmbsb1.685e-5036.47porphobilinogen deaminase-like [Source:NCBI gene;A... [more]
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BLAST of Porphobilinogen deaminase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
hmbsa4.019e-5140.83hydroxymethylbilane synthase a [Source:ZFIN;Acc:ZD... [more]
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BLAST of Porphobilinogen deaminase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
HEM31.756e-4833.01Porphobilinogen deaminase; catalyzes the conversio... [more]
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BLAST of Porphobilinogen deaminase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Porphobilinogen deaminase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
hmbsb6.003e-5235.90hydroxymethylbilane synthase [Source:NCBI gene;Acc... [more]
hmbsb6.003e-5235.90hydroxymethylbilane synthase [Source:NCBI gene;Acc... [more]
hmbsb6.688e-5235.90hydroxymethylbilane synthase [Source:NCBI gene;Acc... [more]
hmbsb1.815e-4737.94hydroxymethylbilane synthase [Source:NCBI gene;Acc... [more]
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BLAST of Porphobilinogen deaminase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000025072.10.000e+099.74SMESG000025072.1[more]
SMESG000024741.11.023e-8941.35SMESG000024741.1[more]
SMESG000071507.13.494e-8540.77SMESG000071507.1[more]
SMESG000024670.15.107e-7739.95SMESG000024670.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30007511 ID=SMED30007511|Name=Porphobilinogen deaminase|organism=Schmidtea mediterranea sexual|type=transcript|length=1272bp
CAACGATTTCGTCACTAGAATCATTTATTTTTTATCAATTATGTTTAATT
TATCTTCTAAATTTTCCAAAAAAACCTTTCGAATAGGAACTCGAAGTAGC
CCTTTAGCATTAGCTCAAACCAACCGAATAGTAGAGTTATTGAAATCAAA
AGATGCGAATTTAGAATATCAAATCTTGACTCCAGAAAATATTACTGAAA
AACTCACTATGAAGGAATTAGCGAACATCGAAGATCTCTCATACAAAAAA
TTATCACATATCGCTTTAAATCTTCATGAATTGGATATAATCGTTCATTC
AATGAAGGACGTTTCCAAAAAGCTTTCACCTGAATTTGTAATTGGATGCA
TATGTATGAGAGATAGTTGTGAAGACGTTGTCGTAATGCGTGTGGATCTT
CAGGGGAAAACTTTAGAAGAATTACCCATTGGTTCAGTTATCGGAACAAG
CTCTTTGAGACGAATTTCCAAATTAAAAAGAAAATACCCGCATTTTGATA
TTATACCTATTAAAGGGGACTTGGACAAGAGAATTCAAAAATTAGATGAC
CAACAAACGGATCCTGGAGCGAGCCGAAAACCATACAGTGCTCTGATTTT
GGCTAAGGCCGGTATTATTCGGTTAAATCTGGAACATCGAATTAGTCAGG
AATTAATATTCACGGATACATTTTATGCGGTGGGACAAGGAGCACTGGCA
TGTGAGTGTCGAACTGATGATCCCGAAACTCGAGAATTGCTGTCAGTGAT
AAACGATGAAAAATCCATGTTAAGCTGCATTGGTGAAAGAAGTTTTTTGA
AAGCGTTTGATTGTAGAGCTTCAGAAGCCGTAGCAGTCCAGTCAGTTTTT
ACAGAATCCGATTATACATTGAAAGCGTGCGTGTCGAGCAATGACGGCAG
CAAATGTATTGAAAAGGAAAAAACTTTAACGTTGTGTGATAATTTAGTGG
AAAGCGAAAAAAATGATTTACCAGAAAATGAAAACTTTACTGGGATATTA
ATATGGGGAATTGATAAGCTAACTTTGACAAAAATGCAGAAATGTAGAAA
TCTTGGAGAAAACGTTGCCAAATTATTAAAATCCTCTGATGCTGATATTA
TTCTCCATGAAAATCGCAAAGAAAAAAAGTGTTCAAAGCATAAATAATGG
AACATCAAGATTATTGAACTCATGAACTGACTTTATTGAAGTGTGATTAA
AACACTTTCAGTCATTTTTAAGAATTTTTTCTCATTTGTAATTTAATTTA
ATTGAAAACATTAATACAACAG
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protein sequence of SMED30007511-orf-1

>SMED30007511-orf-1 ID=SMED30007511-orf-1|Name=SMED30007511-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=382bp
NDFVTRIIYFLSIMFNLSSKFSKKTFRIGTRSSPLALAQTNRIVELLKSK
DANLEYQILTPENITEKLTMKELANIEDLSYKKLSHIALNLHELDIIVHS
MKDVSKKLSPEFVIGCICMRDSCEDVVVMRVDLQGKTLEELPIGSVIGTS
SLRRISKLKRKYPHFDIIPIKGDLDKRIQKLDDQQTDPGASRKPYSALIL
AKAGIIRLNLEHRISQELIFTDTFYAVGQGALACECRTDDPETRELLSVI
NDEKSMLSCIGERSFLKAFDCRASEAVAVQSVFTESDYTLKACVSSNDGS
KCIEKEKTLTLCDNLVESEKNDLPENENFTGILIWGIDKLTLTKMQKCRN
LGENVAKLLKSSDADIILHENRKEKKCSKHK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002075pigment cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036803Porphobilinogen_deaminase_C_sf
IPR000860HemC
IPR022418Porphobilinogen_deaminase_C
IPR022417Porphobilin_deaminase_N
Vocabulary: biological process
TermDefinition
GO:0033014tetrapyrrole biosynthetic process
GO:0018160peptidyl-pyrromethane cofactor linkage
Vocabulary: molecular function
TermDefinition
GO:0004418hydroxymethylbilane synthase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000860Porphobilinogen deaminasePRINTSPR00151PORPHBDMNASEcoord: 146..163
score: 56.61
coord: 95..114
score: 44.05
coord: 261..278
score: 25.13
coord: 165..182
score: 33.33
IPR000860Porphobilinogen deaminaseTIGRFAMTIGR00212TIGR00212coord: 27..308
e-value: 7.8E-67
score: 223.3
IPR000860Porphobilinogen deaminasePANTHERPTHR11557PORPHOBILINOGEN DEAMINASEcoord: 20..376
IPR022418Porphobilinogen deaminase, C-terminalPFAMPF03900Porphobil_deamCcoord: 257..308
e-value: 1.4E-4
score: 22.2
IPR036803Porphobilinogen deaminase, C-terminal domain superfamilyGENE3DG3DSA:3.30.160.40coord: 252..378
e-value: 5.6E-17
score: 64.1
IPR036803Porphobilinogen deaminase, C-terminal domain superfamilySUPERFAMILYSSF54782Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domaincoord: 251..313
IPR022417Porphobilinogen deaminase, N-terminalPFAMPF01379Porphobil_deamcoord: 27..244
e-value: 4.0E-52
score: 176.7
NoneNo IPR availableGENE3DG3DSA:3.40.190.10coord: 27..242
e-value: 6.1E-58
score: 197.4
NoneNo IPR availableGENE3DG3DSA:3.40.190.10coord: 119..230
e-value: 6.1E-58
score: 197.4
NoneNo IPR availableSUPERFAMILYSSF53850Periplasmic binding protein-like IIcoord: 24..250