PCI domain-containing protein

Overview
NamePCI domain-containing protein
Smed IDSMED30007345
Length (bp)1334
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of PCI domain-containing protein (SMED30007345) t-SNE clustered cells

Violin plots show distribution of expression levels for PCI domain-containing protein (SMED30007345) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30007345

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
reproductive organSMED30007345SMESG000007206.1 Contig35824newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30007345SMESG000007206.1 Contig35824uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Human
Match: PCID2 (PCI domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25653])

HSP 1 Score: 324.324 bits (830), Expect = 3.535e-107
Identity = 168/395 (42.53%), Postives = 241/395 (61.01%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I S++G   A+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A   N+     VK      G  +  A + +   F  C+ D     E SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S + +VT+ YYVGRK +FD++F++A EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + ++V  GN+  L   L K++AFFI CGI+LILEKLK I YRNLFK V   ++ H + +  F  ALKF  V D+D+DE  CILANLI+   +KGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFA---NNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Human
Match: PCID2 (PCI domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25653])

HSP 1 Score: 324.324 bits (830), Expect = 3.535e-107
Identity = 168/395 (42.53%), Postives = 241/395 (61.01%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I S++G   A+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A   N+     VK      G  +  A + +   F  C+ D     E SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S + +VT+ YYVGRK +FD++F++A EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + ++V  GN+  L   L K++AFFI CGI+LILEKLK I YRNLFK V   ++ H + +  F  ALKF  V D+D+DE  CILANLI+   +KGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFA---NNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Human
Match: PCID2 (PCI domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25653])

HSP 1 Score: 324.324 bits (830), Expect = 3.535e-107
Identity = 168/395 (42.53%), Postives = 241/395 (61.01%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I S++G   A+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A   N+     VK      G  +  A + +   F  C+ D     E SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S + +VT+ YYVGRK +FD++F++A EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + ++V  GN+  L   L K++AFFI CGI+LILEKLK I YRNLFK V   ++ H + +  F  ALKF  V D+D+DE  CILANLI+   +KGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFA---NNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Human
Match: PCID2 (PCI domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25653])

HSP 1 Score: 322.013 bits (824), Expect = 3.055e-106
Identity = 168/396 (42.42%), Postives = 242/396 (61.11%), Query Frame = 3 
Query:   93 MTIESLIANIV-RNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            M +  ++  +V   I S++G   A+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A   N+     VK      G  +  A + +   F  C+ D     E SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S + +VT+ YYVGRK +FD++F++A EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + ++V  GN+  L   L K++AFFI CGI+LILEKLK I YRNLFK V   ++ H + +  F  ALKF  V D+D+DE  CILANLI+   +KGY++HQ QKLV+SK N FP L
Sbjct:    1 MRLTDVVQQLVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFA---NNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPL 393
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Human
Match: PCID2 (PCI domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25653])

HSP 1 Score: 322.013 bits (824), Expect = 3.055e-106
Identity = 168/396 (42.42%), Postives = 242/396 (61.11%), Query Frame = 3 
Query:   93 MTIESLIANIV-RNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            M +  ++  +V   I S++G   A+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A   N+     VK      G  +  A + +   F  C+ D     E SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S + +VT+ YYVGRK +FD++F++A EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + ++V  GN+  L   L K++AFFI CGI+LILEKLK I YRNLFK V   ++ H + +  F  ALKF  V D+D+DE  CILANLI+   +KGY++HQ QKLV+SK N FP L
Sbjct:    1 MRLTDVVQQLVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFA---NNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPL 393
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Celegans
Match: C27F2.10 (PCI domain-containing protein 2 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q95QU0])

HSP 1 Score: 290.812 bits (743), Expect = 2.143e-94
Identity = 166/409 (40.59%), Postives = 248/409 (60.64%), Query Frame = 3 
Query:   75 NIEDFEMTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTL----IGFHSEYVKMGSQFSLWKEMLIAHLKIINYVH-DKNFKCAFDYQIQLIQLI-FDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNS-KTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLG-IAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +IED+   IESL+          NG +++K  S  D H Q+  +     G  S+  ++ S+  ++ E++  HL ++  +H  ++   A   QIQ+IQL   ++ ++ +++NWFLP+ Y +  DLR L+    +  +G    D   ++ S    A   I   +  C  D +    ++K++ M+ M NQLF+IYF IN+  L KPLI AI+N G +   F +S +V +NY++GRK +FD +   A + L +AF NC  +S+ NK+ IL+YLIPVKM +G +    LL +Y L EF  ++  V++GN++ LD  L  N+AFFI CGI+L+LEKL+ I +R LFK VS+ +    IP+  F  AL+F GV D+DMDE  CI+ANLI   KIKGYL+HQ QKLVISK NAFP+L
Sbjct:    6 SIEDYFGQIESLL----YRQDWTNGEKISKFVSTYDEHAQEPFMHIEAYGSRSKRCRV-SEDEVFDEIVCLHLHVLYNIHVAQDLITAQSTQIQIIQLFNKEILQKRKDENWFLPIFYRLCTDLRWLSKGAEACVSGDDEGD--SNANSFFESAAKAITECYRTCVSDVHAEEGTTKKVAMLNMTNQLFQIYFQINKLNLLKPLIRAIDNCGSLYHDFLMSDKVAYNYFLGRKAMFDADLNLAEKSLLYAFRNCPADSMSNKRKILIYLIPVKMFLGHMPTSQLLHEYRLDEFQDVVAGVKDGNLAQLDGALAANEAFFIKCGIFLMLEKLRMITFRTLFKKVSQIVGTAQIPLDAFQTALRFVGVTDVDMDELECIIANLIASKKIKGYLSHQHQKLVISKMNAFPTL 407
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Celegans
Match: C27F2.10 (PCI domain-containing protein 2 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q95QU0])

HSP 1 Score: 290.812 bits (743), Expect = 2.143e-94
Identity = 166/409 (40.59%), Postives = 248/409 (60.64%), Query Frame = 3 
Query:   75 NIEDFEMTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTL----IGFHSEYVKMGSQFSLWKEMLIAHLKIINYVH-DKNFKCAFDYQIQLIQLI-FDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNS-KTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLG-IAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +IED+   IESL+          NG +++K  S  D H Q+  +     G  S+  ++ S+  ++ E++  HL ++  +H  ++   A   QIQ+IQL   ++ ++ +++NWFLP+ Y +  DLR L+    +  +G    D   ++ S    A   I   +  C  D +    ++K++ M+ M NQLF+IYF IN+  L KPLI AI+N G +   F +S +V +NY++GRK +FD +   A + L +AF NC  +S+ NK+ IL+YLIPVKM +G +    LL +Y L EF  ++  V++GN++ LD  L  N+AFFI CGI+L+LEKL+ I +R LFK VS+ +    IP+  F  AL+F GV D+DMDE  CI+ANLI   KIKGYL+HQ QKLVISK NAFP+L
Sbjct:    6 SIEDYFGQIESLL----YRQDWTNGEKISKFVSTYDEHAQEPFMHIEAYGSRSKRCRV-SEDEVFDEIVCLHLHVLYNIHVAQDLITAQSTQIQIIQLFNKEILQKRKDENWFLPIFYRLCTDLRWLSKGAEACVSGDDEGD--SNANSFFESAAKAITECYRTCVSDVHAEEGTTKKVAMLNMTNQLFQIYFQINKLNLLKPLIRAIDNCGSLYHDFLMSDKVAYNYFLGRKAMFDADLNLAEKSLLYAFRNCPADSMSNKRKILIYLIPVKMFLGHMPTSQLLHEYRLDEFQDVVAGVKDGNLAQLDGALAANEAFFIKCGIFLMLEKLRMITFRTLFKKVSQIVGTAQIPLDAFQTALRFVGVTDVDMDELECIIANLIASKKIKGYLSHQHQKLVISKMNAFPTL 407
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Fly
Match: PCID2 (gene:FBgn0036184 transcript:FBtr0076102)

HSP 1 Score: 294.664 bits (753), Expect = 5.596e-96
Identity = 155/400 (38.75%), Postives = 238/400 (59.50%), Query Frame = 3 
Query:   96 TIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQF--SLWKEMLIAHLKIINYV--HDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHL 1283
            T+ + ++ ++   +  +G  LA   SL D H+Q+  L     E  K+  +F      E++ AHLK++ ++      +  A+  Q      +  L +Q++++NW LP++Y + +DLR LA A                G  +  A D I   F  C+ D   + E +KRLGMM + NQLFKIYF IN+  LCKPLI AI+N    + F +  Q+T+ Y+VGR+ +FD+N+Q AV+YL++AF NC      NK+ IL+YL+PVKML+G L  +SLL +Y+L  F+ +  +++ GN++  D  +   +   I  GIYL++EKLK++ YRNLFK V    ++H + +  F  AL F G+ D+ +DET CI+ANLI++ KIKGY++H   KLV+SK N FPS+ L
Sbjct:    4 TVNNYLSGVLHAAQDLDGESLATYLSLRDVHVQNHNLYIAQPE--KLVDRFLKPPLDEVVSAHLKVLYHLAQEPPGYMEAYTQQSAACGAVVRLLQQLKDENWCLPLMYRVCLDLRYLAQACEKHCQGFT------PGHVLEKAADCIMACFRVCAADGRASEEDTKRLGMMNLVNQLFKIYFRINKLHLCKPLIRAIDNCIFKDSFPLPEQITYKYFVGRRAMFDSNYQAAVQYLSYAFSNCPDRFASNKRLILIYLVPVKMLLGYLPSKSLLQRYDLLLFLDLAMAMKAGNVNRFDEIVRDQELVLIRSGIYLLVEKLKFLVYRNLFKKVFVIRKSHQLDMGDFLSALHFVGLTDVSLDETHCIVANLIYDGKIKGYISHAHNKLVVSKQNPFPSVSL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Zebrafish
Match: pcid2 (PCI domain containing 2 [Source:NCBI gene;Acc:492509])

HSP 1 Score: 299.286 bits (765), Expect = 1.403e-97
Identity = 156/395 (39.49%), Postives = 241/395 (61.01%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +T+   +  ++  I S++G   A+  S    H+ +  L     E          + EM+ AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LP+++A+++DLR+ A     +   K K      G  +  A + +   F  C+ D     + SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + ++++++ +VT+ YYVGRK +FD++F+ A E L+F+F +CHR+  +NK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L++ L K++ FFI CGI+LILEKLK I YRNLFK V   +  H +P++ F  +L+   V D+D+DE  CILANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITLNQYLQQVLEAIDSRDGSFCAEMLSFKHPHVANPRLQLSSPEEKCQQLLEPPYDEMVAAHLRCTFAVSNHDFVEAYKCQTVVVQSFLKAFQAHKEENWALPIMFAVTLDLRIFANNAEQQLQQKGKG---KVGDMLEKAAEQLMSCFRVCASDNRAGIDDSKKWGMLFLINQLFKIYFKINKLHLCKPLIRAIDSSNLKDEYTMAQRVTYKYYVGRKAMFDSDFKPAEECLSFSFTHCHRSCQRNKRLILIYLLPVKMLLGHMPTHQLLKKYDLMQFADVTKAVSEGNLLLLNAALVKHETFFIRCGIFLILEKLKIITYRNLFKKVYHLLRTHQLPLAAFLVSLQMMKVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Zebrafish
Match: pcid2 (PCI domain containing 2 [Source:NCBI gene;Acc:492509])

HSP 1 Score: 299.286 bits (765), Expect = 1.403e-97
Identity = 156/395 (39.49%), Postives = 241/395 (61.01%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +T+   +  ++  I S++G   A+  S    H+ +  L     E          + EM+ AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LP+++A+++DLR+ A     +   K K      G  +  A + +   F  C+ D     + SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + ++++++ +VT+ YYVGRK +FD++F+ A E L+F+F +CHR+  +NK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L++ L K++ FFI CGI+LILEKLK I YRNLFK V   +  H +P++ F  +L+   V D+D+DE  CILANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITLNQYLQQVLEAIDSRDGSFCAEMLSFKHPHVANPRLQLSSPEEKCQQLLEPPYDEMVAAHLRCTFAVSNHDFVEAYKCQTVVVQSFLKAFQAHKEENWALPIMFAVTLDLRIFANNAEQQLQQKGKG---KVGDMLEKAAEQLMSCFRVCASDNRAGIDDSKKWGMLFLINQLFKIYFKINKLHLCKPLIRAIDSSNLKDEYTMAQRVTYKYYVGRKAMFDSDFKPAEECLSFSFTHCHRSCQRNKRLILIYLLPVKMLLGHMPTHQLLKKYDLMQFADVTKAVSEGNLLLLNAALVKHETFFIRCGIFLILEKLKIITYRNLFKKVYHLLRTHQLPLAAFLVSLQMMKVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Xenopus
Match: rnf138 (ring finger protein 138 [Source:Xenbase;Acc:XB-GENE-1001373])

HSP 1 Score: 330.102 bits (845), Expect = 1.907e-109
Identity = 171/395 (43.29%), Postives = 246/395 (62.28%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I S+NG+  A   S    H+ +  L     E          + EM  AHL+ IN V + +F  A+ YQ  ++Q     F+  +E+NW LP++Y+I++DLR+ A   N+     VK      G  +  A + +   F  C+ D   +FE SK+ GM+ + NQLFKIYF I++  LCKPLI AI++    E+++++ +VT+ YYVGRK +FD++F+KA EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L   L+K++ FFI CGI+LILE LK I+YRNLFK V   ++ H + +  F  ALKF  V DID+ E  CI+ANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVQEAIDSKNGYNCADLVSFRHPHVANARLQLSSPEEKCQQVLEPPYDEMFAAHLRCINAVSNHDFVEAYKYQTLVVQSFLKSFQAHKEENWALPIMYSITLDLRIFA---NNADQQLVKKGKGKVGDMLEKAAELLMSCFRVCASDTRASFEDSKKWGMLFLVNQLFKIYFKISKLHLCKPLIRAIDSSNFKEEYTMAQRVTYKYYVGRKSMFDSDFKKAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPAIQLLKKYDLMQFAEVTKAVSEGNLLLLTEALSKHETFFIRCGIFLILENLKIISYRNLFKKVYLLLKTHQLSLDAFLVALKFMEVEDIDLAEVQCIIANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Xenopus
Match: rnf138 (ring finger protein 138 [Source:Xenbase;Acc:XB-GENE-1001373])

HSP 1 Score: 309.686 bits (792), Expect = 8.835e-102
Identity = 166/395 (42.03%), Postives = 238/395 (60.25%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I S+NG+  A   S    H+ +  L     E          + EM  AHL+ IN V + +F  A+ YQ  ++ L               P++Y+I++DLR+ A   N+     VK      G  +  A + +   F  C+ D   +FE SK+ GM+ + NQLFKIYF I++  LCKPLI AI++    E+++++ +VT+ YYVGRK +FD++F+KA EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L   L+K++ FFI CGI+LILE LK I+YRNLFK V   ++ H + +  F  ALKF  V DID+ E  CI+ANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVQEAIDSKNGYNCADLVSFRHPHVANARLQLSSPEEKCQQVLEPPYDEMFAAHLRCINAVSNHDFVEAYKYQTLVVAL---------------PIMYSITLDLRIFA---NNADQQLVKKGKGKVGDMLEKAAELLMSCFRVCASDTRASFEDSKKWGMLFLVNQLFKIYFKISKLHLCKPLIRAIDSSNFKEEYTMAQRVTYKYYVGRKSMFDSDFKKAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPAIQLLKKYDLMQFAEVTKAVSEGNLLLLTEALSKHETFFIRCGIFLILENLKIISYRNLFKKVYLLLKTHQLSLDAFLVALKFMEVEDIDLAEVQCIIANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 380
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Xenopus
Match: rnf138 (ring finger protein 138 [Source:Xenbase;Acc:XB-GENE-1001373])

HSP 1 Score: 306.605 bits (784), Expect = 1.411e-100
Identity = 164/382 (42.93%), Postives = 233/382 (60.99%), Query Frame = 3 
Query:  132 IRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            I S+NG+  A   S    H+ +  L     E          + EM  AHL+ IN V + +F  A+ YQ  ++ L               P++Y+I++DLR+ A   N+     VK      G  +  A + +   F  C+ D   +FE SK+ GM+ + NQLFKIYF I++  LCKPLI AI++    E+++++ +VT+ YYVGRK +FD++F+KA EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L   L+K++ FFI CGI+LILE LK I+YRNLFK V   ++ H + +  F  ALKF  V DID+ E  CI+ANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:   16 IDSKNGYNCADLVSFRHPHVANARLQLSSPEEKCQQVLEPPYDEMFAAHLRCINAVSNHDFVEAYKYQTLVVAL---------------PIMYSITLDLRIFA---NNADQQLVKKGKGKVGDMLEKAAELLMSCFRVCASDTRASFEDSKKWGMLFLVNQLFKIYFKISKLHLCKPLIRAIDSSNFKEEYTMAQRVTYKYYVGRKSMFDSDFKKAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPAIQLLKKYDLMQFAEVTKAVSEGNLLLLTEALSKHETFFIRCGIFLILENLKIISYRNLFKKVYLLLKTHQLSLDAFLVALKFMEVEDIDLAEVQCIIANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 379
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Xenopus
Match: rnf138 (ring finger protein 138 [Source:Xenbase;Acc:XB-GENE-1001373])

HSP 1 Score: 303.908 bits (777), Expect = 5.951e-100
Identity = 155/341 (45.45%), Postives = 220/341 (64.52%), Query Frame = 3 
Query:  255 WKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            + EM  AHL+ IN V + +F  A+ YQ  ++ L               P++Y+I++DLR+ A   N+     VK      G  +  A + +   F  C+ D   +FE SK+ GM+ + NQLFKIYF I++  LCKPLI AI++    E+++++ +VT+ YYVGRK +FD++F+KA EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L   L+K++ FFI CGI+LILE LK I+YRNLFK V   ++ H + +  F  ALKF  V DID+ E  CI+ANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:   20 YDEMFAAHLRCINAVSNHDFVEAYKYQTLVVAL---------------PIMYSITLDLRIFA---NNADQQLVKKGKGKVGDMLEKAAELLMSCFRVCASDTRASFEDSKKWGMLFLVNQLFKIYFKISKLHLCKPLIRAIDSSNFKEEYTMAQRVTYKYYVGRKSMFDSDFKKAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPAIQLLKKYDLMQFAEVTKAVSEGNLLLLTEALSKHETFFIRCGIFLILENLKIISYRNLFKKVYLLLKTHQLSLDAFLVALKFMEVEDIDLAEVQCIIANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 342
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Xenopus
Match: rnf138 (ring finger protein 138 [Source:Xenbase;Acc:XB-GENE-1001373])

HSP 1 Score: 292.738 bits (748), Expect = 2.643e-95
Identity = 164/395 (41.52%), Postives = 232/395 (58.73%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I S+NG+  A   S    H+ +  L     E          + EM  AHL+ IN V + +F  A+ YQ     L+F +             V  I  D +L+      K   KV D+       +  A + +   F  C+ D   +FE SK+ GM+ + NQLFKIYF I++  LCKPLI AI++    E+++++ +VT+ YYVGRK +FD++F+KA EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L   L+K++ FFI CGI+LILE LK I+YRNLFK V   ++ H + +  F  ALKF  V DID+ E  CI+ANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVQEAIDSKNGYNCADLVSFRHPHVANARLQLSSPEEKCQQVLEPPYDEMFAAHLRCINAVSNHDFVEAYKYQT----LVFYM------------AVAPIKADQQLV-----KKGKGKVGDM-------LEKAAELLMSCFRVCASDTRASFEDSKKWGMLFLVNQLFKIYFKISKLHLCKPLIRAIDSSNFKEEYTMAQRVTYKYYVGRKSMFDSDFKKAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPAIQLLKKYDLMQFAEVTKAVSEGNLLLLTEALSKHETFFIRCGIFLILENLKIISYRNLFKKVYLLLKTHQLSLDAFLVALKFMEVEDIDLAEVQCIIANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 370
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Mouse
Match: Pcid2 (PCI domain containing 2 [Source:MGI Symbol;Acc:MGI:2443003])

HSP 1 Score: 313.923 bits (803), Expect = 3.188e-103
Identity = 167/395 (42.28%), Postives = 241/395 (61.01%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I +++G   A+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A   N+     VK      G  +  A + +   F  C+ D     E SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S + ++T+ YYVGRK +FD++F++A EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L+  L K++ FFI CGI+LILEKLK I YRNLFK V   ++ H + +  F  ALKF  V D+D+DE  CILANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVYEAIDTRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFA---NNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRITYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTIELLRKYHLMQFSEVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMHVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Mouse
Match: Pcid2 (PCI domain containing 2 [Source:MGI Symbol;Acc:MGI:2443003])

HSP 1 Score: 55.4546 bits (132), Expect = 4.571e-9
Identity = 32/116 (27.59%), Postives = 56/116 (48.28%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLA 440
            +TI   +  +   I +++G   A+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A
Sbjct:    4 ITINQYLQQVYEAIDTRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFA 119
[Close]
BLAST of PCI domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5FWP8|PCID2_XENLA (PCI domain-containing protein 2 OS=Xenopus laevis OX=8355 GN=pcid2 PE=2 SV=1)

HSP 1 Score: 330.872 bits (847), Expect = 4.731e-109
Identity = 171/395 (43.29%), Postives = 244/395 (61.77%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I S++G   A   S    H+ +  L     E          + EM  AHL+ IN   + +F  A+ YQ  ++Q     F+  +E+NW LP++Y+I++DLR+ A   N+     VK      G  +  A + +   F  C+ D    FE SK+ GM+ + NQLFKIYF I++  LCKPLI AI++    E+++++ +VTF YYVGRK +FD++F+KA EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L   L K++ FFI CGI+LILEKLK I+YRNLFK V   ++ H + +  F  ALKF  V D+D+DE  CI+ANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVQEAIDSKDGFNCADLVSFKHPHVANARLQLLSPEEKCQQVLEPPYDEMFAAHLRCINAASNHDFVEAYKYQTLVVQSFLKSFQAHKEENWALPIMYSITLDLRIFA---NNADQQLVKKGKGKVGDMLEKAAEILMSCFRVCASDTRAAFEDSKKWGMLFLVNQLFKIYFKISKLHLCKPLIRAIDSSNFKEEYTMAQRVTFKYYVGRKSMFDSDFKKAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTIHLLKKYDLMQFAEVTKAVSEGNLLLLTEALTKHETFFIRCGIFLILEKLKIISYRNLFKKVYLLLKTHQLSLDAFLVALKFMEVGDVDIDEVQCIIANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5JVF3|PCID2_HUMAN (PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2)

HSP 1 Score: 324.324 bits (830), Expect = 1.698e-106
Identity = 168/395 (42.53%), Postives = 241/395 (61.01%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I S++G   A+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A   N+     VK      G  +  A + +   F  C+ D     E SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S + +VT+ YYVGRK +FD++F++A EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + ++V  GN+  L   L K++AFFI CGI+LILEKLK I YRNLFK V   ++ H + +  F  ALKF  V D+D+DE  CILANLI+   +KGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFA---NNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8BFV2|PCID2_MOUSE (PCI domain-containing protein 2 OS=Mus musculus OX=10090 GN=Pcid2 PE=1 SV=1)

HSP 1 Score: 313.923 bits (803), Expect = 2.230e-102
Identity = 167/395 (42.28%), Postives = 241/395 (61.01%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I +++G   A+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A   N+     VK      G  +  A + +   F  C+ D     E SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S + ++T+ YYVGRK +FD++F++A EYL+FAFE+CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L+  L K++ FFI CGI+LILEKLK I YRNLFK V   ++ H + +  F  ALKF  V D+D+DE  CILANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVYEAIDTRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFA---NNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRITYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTIELLRKYHLMQFSEVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMHVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. UniProt/SwissProt
Match: sp|Q2TBN6|PCID2_BOVIN (PCI domain-containing protein 2 OS=Bos taurus OX=9913 GN=PCID2 PE=2 SV=1)

HSP 1 Score: 304.679 bits (779), Expect = 8.905e-99
Identity = 165/404 (40.84%), Postives = 241/404 (59.65%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSK---------AMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  +   I +++G  LA+  S    H+ +  L     E          + EM  AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV+YA+++DLR+ A   N+     VK      G  +  A + +   F  C+ D     E SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S + +VT+ YYVGRK +FD++F++A EYL+FAFE+CHR+S KNK+ +L+YL+PVKML+G +    LL KY+L +F  + ++V  GN+  L+  L  ++ FFI CGI+LILEKLK I YRNLFK V+           ++ H + +  F  ALKF  V D+D+ E  CILANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVCEAIDTRDGASLAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFA---NNADQQLVKKGKSKVGDMLEKAAELLMGCFRVCASDTRAGIEDSKKRGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYRYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMVLIYLLPVKMLLGHMPTIELLRKYHLMQFAEVTRAVSEGNLLLLNEALAAHETFFIRCGIFLILEKLKIITYRNLFKKVNSLSSASSRYLLLKTHQLSLDAFLVALKFMQVEDVDIAEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 404
[Close]
BLAST of PCI domain-containing protein vs. UniProt/SwissProt
Match: sp|Q60YJ7|PCID2_CAEBR (PCI domain-containing protein 2 homolog OS=Caenorhabditis briggsae OX=6238 GN=CBG18211 PE=3 SV=1)

HSP 1 Score: 302.368 bits (773), Expect = 8.354e-98
Identity = 173/415 (41.69%), Postives = 252/415 (60.72%), Query Frame = 3 
Query:   66 FKYNIEDFEMTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTL----IGFHSEYVKMGSQFSLWKEMLIAHLKIINYVH-DKNFKCAFDYQIQLIQLI-FDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLG-IAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHLTS 1289
            F  NI D+   I+    N+  N   ++G ++AK  SLND H ++  L     G  S   ++ S+  +  E++  HL +++ VH  K+   +   QI++IQL   ++ ++ +++NWFLP+ Y +  DLR L+    S   S   +   ++ S    A   I   +  C  D +     +K++ M+ M NQLF+IYF IN+  L KPLI AI+N G +  KF ++ +V +NY++GRK +FD +   A + L +AF NC   SV NK+ IL+YLIPVKM +G +   SLL +Y L EF  ++ +V++G++  +D+ L  N  FFI CGIYL+LEKL+ I YRNLFK VS+ +    IP+  F  AL+F GV D+DMDE  CI+ANLI E K+KGYLAHQ QKLVISKTNAFP+L   S
Sbjct:    3 FVRNISDYFNKID----NLCYNQSWESGDKIAKYLSLNDDHSKEAYLHISEYGSTSRRCRV-SEDEIIDEIVCLHLHVLHSVHVAKDLISSQSTQIRIIQLFNKEILQKRKDENWFLPIFYRLCTDLRWLSKGAES-CASGDDEGDSNANSFFESAAKAITECYRTCVSDVHAEEGKTKKVAMLNMTNQLFQIYFQINKLNLLKPLIRAIDNCGPLYNKFLMADKVAYNYFLGRKALFDGDLILAEKGLVYAFRNCPTESVSNKRKILVYLIPVKMFLGHMPTASLLHRYRLDEFQEVVAAVKDGHLGRVDNALLTNGEFFIKCGIYLVLEKLRTITYRNLFKKVSQMVGKVQIPLDAFQAALRFVGVTDVDMDELECIIANLIAEKKVKGYLAHQHQKLVISKTNAFPTLSSVS 411
[Close]
BLAST of PCI domain-containing protein vs. TrEMBL
Match: A0A4S2MAW6 (PCI domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_002678 PE=4 SV=1)

HSP 1 Score: 392.889 bits (1008), Expect = 9.521e-131
Identity = 192/391 (49.10%), Postives = 259/391 (66.24%), Query Frame = 3 
Query:  132 IRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHLTSLTITR 1304
            I S+NG ELA      D H+ +  L     E + M    + W E   AH++ +  +  ++F+ A+  Q+ L++ +  +  +I+E+NW LPVV A ++DLR  A  +++K  S    L R  G  M  A   I RLF  C+ D  T  + SK+LGMM + NQLFKIYF IN+  LCKP+I AIEN+ I ++FS++ +VT++YYVGRK +FD +F  A + L+FAFE C  ++  NK+ IL+YLIPVKML+G+    SLL+KYNL EF+GI  + + GN+  +D ELNK + FF++CG+YLILEKLK I YRNLFK V   M+ HL+PI VF  AL+  GV DID DET CILANLI+E KIKGYLAHQQQKLV+SK  AFP+L     T+TR
Sbjct:   17 INSRNGKELAHTLECRDPHVYNPRLANPEPESMVMKHVSTPWDEAFSAHMRCVWAMRKQDFEEAYACQVVLVKTVARILIEIKEENWMLPVVLATAIDLRRFAHGLDAKAVSNKNQLGRGHGRHMETAAQLILRLFQICASDSRTQLDDSKKLGMMGLANQLFKIYFQINKLNLCKPMIRAIENMNINDRFSLAQRVTYSYYVGRKAMFDGDFVSADKSLSFAFERCLGSAWHNKRLILIYLIPVKMLLGVFPYPSLLVKYNLNEFLGISDAAKAGNLQKMDMELNKYEEFFLSCGVYLILEKLKLITYRNLFKKVCAIMKTHLMPIEVFTAALRLMGVEDIDQDETECILANLIYEGKIKGYLAHQQQKLVVSKLQAFPALTAAMTTMTR 407
[Close]
BLAST of PCI domain-containing protein vs. TrEMBL
Match: A0A504YG57 (PCI domain-containing protein 2 OS=Fasciola gigantica OX=46835 GN=FGIG_09633 PE=4 SV=1)

HSP 1 Score: 375.941 bits (964), Expect = 4.554e-124
Identity = 186/398 (46.73%), Postives = 263/398 (66.08%), Query Frame = 3 
Query:  132 IRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGS-------KVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHLTSLTITR 1304
            I+++NG  L+K  + +D H+ +  L     E + M    + W E+  AH++ I     K+F+ A+  Q+ +++ +  +  +++E+NW LPVV ++++DLR  A  ++S           K    +R  G  M  A   I +LF  C+ D  T  E SK+LGMM + NQLFKIYF IN+  LCK +I AI+NLG+ ++FS++ +VT+ YYVGRK +FD +F  A + L+FAFE C  ++  NK+ IL+YLIPVKML+GI    SLL KYNL EF+GI ++V++G++  +DSELN++++FF++CG+YLILEKLK I YRNLFK V   M+ HL+PI VF  AL+  G+ DID DET CILANLI+E KIKGYLAHQQQKLV+SK   FP L  T  T  R
Sbjct:   17 IKNKNGPALSKLLACSDPHVYNPRLADPEPESMAMKHLQAPWDEIFSAHMRCIWATRKKDFEEAYACQMIVVKTVGRILTELKEENWILPVVLSVAIDLRRFAHGLDSTAAEANNSGAVKSTSANRMHGRRMETAAQSILKLFQICASDSRTQIEDSKKLGMMGLANQLFKIYFQINKLNLCKSMIRAIDNLGMNDRFSLAQRVTYCYYVGRKAMFDGDFVAADKSLSFAFERCLGSASHNKRLILIYLIPVKMLLGIFPISSLLSKYNLNEFLGISEAVKSGDLRRMDSELNQHESFFLSCGVYLILEKLKLITYRNLFKRVCSIMKTHLLPIDVFTAALRLMGMDDIDQDETECILANLIYEGKIKGYLAHQQQKLVVSKLQPFPPLTSTITTGPR 414
[Close]
BLAST of PCI domain-containing protein vs. TrEMBL
Match: A0A564YH55 (PCI domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS5944 PE=4 SV=1)

HSP 1 Score: 364.77 bits (935), Expect = 5.841e-120
Identity = 188/396 (47.47%), Postives = 255/396 (64.39%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSS-MTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            M+++S +    R + +  G +LA     +D H +++ L   + E +  G   S W E+L AHL+ +  + + ++  A   QI L   +   F + +E+NW LPVV A+ VDLR  A  ++  +G ++ +    S SS +      I RLF  C+ D  T  E SK+ GMM + NQLFKIYF IN+  LCKP+I AIEN+ I   F+++ +VT+NYYVGRK +FD + + A + LTF FE C  +++ NK+  L+YLIPV+ML+GI+   SLL KYNL EF GI  +V+NGN+  L  EL KN+AFFI+CGIYLILEKLK I YRNLFK + + +  HL+PI  F  AL+  GV DID DET CILANLI+E KIKGYLAHQQQKLV+SK   FP L
Sbjct:    2 MSLQSYLYEAERYLNNHQGKQLAACLQCSDKHAKNRNLALPNPENMVAGVFSSPWNEILSAHLRCLWAISENDYDEACRCQIVLAGGLTKAFSEAQEENWLLPVVIAVVVDLRKFAHRLDVTSGIRITEGDDTSYSSYLERVAQSIMRLFQTCAADGRTRTEDSKKCGMMGLANQLFKIYFHINKLNLCKPIIRAIENMNIDAYFTLAQRVTYNYYVGRKAMFDGDLKLANKCLTFTFERCLASNIVNKRLALIYLIPVRMLLGIIPKSSLLHKYNLVEFEGIAVAVKNGNLQRLHDELEKNEAFFISCGIYLILEKLKMITYRNLFKRIGQILNTHLLPIGAFMKALRMMGVEDIDEDETECILANLIYEGKIKGYLAHQQQKLVVSKLQPFPPL 397
[Close]
BLAST of PCI domain-containing protein vs. TrEMBL
Match: A0A5K3EQ90 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 363.999 bits (933), Expect = 1.439e-119
Identity = 191/396 (48.23%), Postives = 252/396 (63.64%), Query Frame = 3 
Query:   96 TIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQF-SLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDS-GSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +++S +    R +   NG ELA      D H  +  L     E V +GS F + W E+  AHL+ +  +   NF+ A   Q+ L++ +  +F +++E+NW LPVV  ++VDLR  A+A++    +K KD S  + GS +      I +LF  C+ D  T  E SK+ GMM + NQLFKIYF IN+  LCKP+I AIEN+ +   FS++ ++TFNYYVGRK +FD +F+ A   LTFAFE C  +   NK+ IL+YLIPV+ML+GI    SLL KY L E  GI  + R GN+  L  EL + + FFI+CGIYLILEKLK + YRNLFK V+  ++ HL PI  F D LK  GV DID DET CILANLI+E KIKGYLAHQQQKLV+SK  AFP L
Sbjct:    5 SVQSYLVEAHRLLSICNGKELATYLQCTDKHALNSRLALAEPETV-VGSVFEAPWDEIFSAHLRCLWAIASNNFEEACACQLVLVKALTKVFSEVKEENWMLPVVIVVAVDLRRFAYALD--ISNKRKDESNSTYGSHLERIAQAIMKLFQICAADSRTAIEDSKKRGMMGLANQLFKIYFQINKLNLCKPIIRAIENMNMDAYFSLAQRITFNYYVGRKAMFDGDFKMANTCLTFAFERCLASHHTNKRLILIYLIPVRMLLGIFPRNSLLQKYKLQELEGIANAARTGNVQKLGEELQRYEGFFISCGIYLILEKLKMLTYRNLFKKVAGLLKTHLQPIPAFTDILKVMGVEDIDTDETECILANLIYEGKIKGYLAHQQQKLVVSKVQAFPPL 397
[Close]
BLAST of PCI domain-containing protein vs. TrEMBL
Match: G4VC10 (PCI domain-containing protein OS=Schistosoma mansoni OX=6183 GN=Smp_148440 PE=4 SV=1)

HSP 1 Score: 363.999 bits (933), Expect = 1.540e-119
Identity = 185/395 (46.84%), Postives = 253/395 (64.05%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +T++  + ++   I S+NG  L+     +D H+ +  L     E + +    S W E++ AH++ I  + +++F+ A+  QI L++ +     ++++DNW LPVV+  ++DLR  A  ++SK   +  D  R+ G  M  A   I RLF  C+ D     E SK+LGMM + NQLFKIYF IN+  LCK +I AI+NL I + FS++ +VT+ YYVGRK +FD +F  A + LTFAFE C      NK+ IL+YLIPVKML+G+L  ESLL KYNL +F  I  SV+ GN+  +DS L  ++AFF++CG+YLILEKLK   YR+LFK V   M+ HL+PI VF  AL   GV DID DET CILANLI E KIKGYLAHQQ KLV+SK   FP L
Sbjct:    4 VTLQMYLQDVTNCINSRNGRGLSHYLMCSDPHVYNSRLAVPDPENIAVSYLVSPWDEIVSAHVRCIWAMRNRDFEEAYACQIVLVKTVAKALSELKDDNWILPVVHVAAIDLRRFAHGLDSKFTPQ-SDSFRNQGRRMENAAQLILRLFQICASDSRAQVEDSKKLGMMGLANQLFKIYFQINKLNLCKSMIRAIDNLSINDHFSLAQRVTYCYYVGRKAMFDGDFVSADKSLTFAFERCLTTKWNNKRLILIYLIPVKMLLGVLPKESLLCKYNLRQFQDIADSVKTGNLRKMDSALEDHEAFFLSCGVYLILEKLKLTVYRSLFKRVCHIMKTHLLPIEVFTAALHLMGVEDIDPDETECILANLIHEGKIKGYLAHQQHKLVVSKLQPFPPL 397
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Cavefish
Match: pcid2 (PCI domain containing 2 [Source:NCBI gene;Acc:103047003])

HSP 1 Score: 297.36 bits (760), Expect = 5.451e-97
Identity = 159/395 (40.25%), Postives = 237/395 (60.00%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  ++  I +++G    +  S    H+ +  L     E          + EM+ AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV++A+++DLR+ A     +   K K      G  +  A + +   F  C+ D     + SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S++ +VT+ YYVGRK +FD+NF+ A EYL+F+F++ HR   +NK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L+  L K++ FFI CGI+LILEKLK I YRNLFK V   ++ H +P+  F  ALK     D+D+DE  CILANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVLEAIETRDGVFCGELLSFKHPHVANPRLQLSSPEDKCQQVLEPPYDEMVAAHLRCTYAVANHDFVEAYKCQTLVVQSFLKAFQAHKEENWALPVMFAVTLDLRIFANNAEQQLQKKGKG---KVGDMLEKAAEQLMSCFRVCASDNRAGIDDSKKWGMLFLINQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSMAQRVTYKYYVGRKAMFDSNFKLAEEYLSFSFQHSHRACQRNKRLILIYLLPVKMLLGHMPTNQLLRKYDLMQFADVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLPLDAFLVALKMMQCEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Cavefish
Match: pcid2 (PCI domain containing 2 [Source:NCBI gene;Acc:103047003])

HSP 1 Score: 297.36 bits (760), Expect = 5.451e-97
Identity = 159/395 (40.25%), Postives = 237/395 (60.00%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  ++  I +++G    +  S    H+ +  L     E          + EM+ AHL+    V + +F  A+  Q  ++Q     F+  +E+NW LPV++A+++DLR+ A     +   K K      G  +  A + +   F  C+ D     + SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + + +S++ +VT+ YYVGRK +FD+NF+ A EYL+F+F++ HR   +NK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L+  L K++ FFI CGI+LILEKLK I YRNLFK V   ++ H +P+  F  ALK     D+D+DE  CILANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQVLEAIETRDGVFCGELLSFKHPHVANPRLQLSSPEDKCQQVLEPPYDEMVAAHLRCTYAVANHDFVEAYKCQTLVVQSFLKAFQAHKEENWALPVMFAVTLDLRIFANNAEQQLQKKGKG---KVGDMLEKAAEQLMSCFRVCASDNRAGIDDSKKWGMLFLINQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSMAQRVTYKYYVGRKAMFDSNFKLAEEYLSFSFQHSHRACQRNKRLILIYLLPVKMLLGHMPTNQLLRKYDLMQFADVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLPLDAFLVALKMMQCEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 395
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Sea Lamprey
Match: pcid2 (PCI domain containing 2 [Source:NCBI gene;Acc:492509])

HSP 1 Score: 308.916 bits (790), Expect = 4.411e-103
Identity = 146/319 (45.77%), Postives = 216/319 (67.71%), Query Frame = 3 
Query:  321 AFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            A+ YQ  ++Q     F+  +E+NW LP++ ++++DLR+ A + + +   K +      G ++  A D +   F  C+ D     + SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + ++++ + +VTF YYVGRK +FD++F++A EYL+FAF +CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+V  GN+  L+  L +++AFFI CGI+LILEKLK I YRNL K V + +  H +P+  F  AL+F  V D+D+DE  CILANLI+   IKGY++HQ QKLV+SK N FP+L
Sbjct:   14 AYKYQTVVVQSFIKAFQADKEENWALPIMNSVTLDLRIFANSADLQLARKGRG---KVGDTLEKAADTLMSCFRVCASDNRAGIDDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSPLKDEYTKAQRVTFKYYVGRKAMFDSDFKQAEEYLSFAFSHCHRSSQKNKRMILIYLLPVKMLLGHMPTLRLLKKYDLMQFADVTKAVSEGNLLLLNEALTRHEAFFIRCGIFLILEKLKIITYRNLSKKVYQLLRTHQLPLDAFLVALRFMKVDDVDLDEVQCILANLIYNGHIKGYISHQHQKLVVSKQNPFPAL 329
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Sea Lamprey
Match: pcid2 (PCI domain containing 2 [Source:NCBI gene;Acc:492509])

HSP 1 Score: 185.652 bits (470), Expect = 1.063e-56
Identity = 90/211 (42.65%), Postives = 141/211 (66.82%), Query Frame = 3 
Query:  321 AFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVR 953
            A+ YQ  ++Q     F+  +E+NW LP++ ++++DLR+ A +V S T   + +     G ++  A D +   F  C+ D     + SK+ GM+ + NQLFKIYF IN+  LCKPLI AI++  + ++++ + +VTF YYVGRK +FD++F++A EYL+FAF +CHR+S KNK+ IL+YL+PVKML+G +    LL KY+L +F  + K+VR
Sbjct:   14 AYKYQTVVVQYPSKAFQADKEENWALPIMNSVTLDLRIFANSV-SLTFHPLLESIHKQGDTLEKAADTLMSCFRVCASDNRAGIDDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSPLKDEYTKAQRVTFKYYVGRKAMFDSDFKQAEEYLSFAFSHCHRSSQKNKRMILIYLLPVKMLLGHMPTLRLLKKYDLMQFADVTKAVR 223
[Close]
BLAST of PCI domain-containing protein vs. Ensembl Yeast
Match: YJR084W (Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome [Source:SGD;Acc:S000003844])

HSP 1 Score: 73.559 bits (179), Expect = 1.234e-14
Identity = 80/400 (20.00%), Postives = 170/400 (42.50%), Query Frame = 3 
Query:  198 QTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQI--EEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENL-------GIAEKFSVSHQ---VTFNYYVGRKY-IFDNNFQKAVEYLTFAFENCHRNSVKNK---------KSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIM--------------KSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENH--LIPISVFCDALKFAGVPDID----MDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFP 1271
            Q       E V++   + L  ++ + + K  +       K A +  ++L      LF +I   E NW +  ++ ++  L  LA    +++    KD   + G +       I R F  C  D+N     +K++G     N  F IY  ++   + K L+  +E+         + +  ++ H+   V +NYY+G+ Y   +N+ ++   +L  A   C    V++          + I++ L+P+ +L   L P      ++ P   G++              +SV +GN+S  ++    ++ FF++ G+++++  L+ + +  L +   +   +   ++P+ +     +     + D    +D   C LA+ I    ++ YL+H  + +V SK   FP
Sbjct:   37 QRPTATDEESVRLQRFYQLGVDLKLKYSKRRSLKKQGRIKNATEELLRLANEQLKLFNRIVERETNWIIYPLWVMAKQLIRLA----NESSELNKDSIEECGRT-------IHRSFTICLNDRNPRLNENKKIGCYMFANLEFSIYHRLSNKDMIKNLVKVLESRVNARDIPPLNKSLAMEHKSQVVLYNYYLGQYYGCLENDHERGFFHLNEALLQCPMLYVESTGKFVLQGQMEKIMILLVPLALLTKRLYPH-----WDHPVIAGVITRSKRLSQVYPTLVRSVISGNLSLYEATAASHERFFLSQGLHVVITLLREVVFTRLVQRCWQWGNDRKSIMPLKILLATKQHDSSANEDEEEQLDALECRLASAIASGLLRAYLSHSNRCIVFSKKEPFP 420
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BLAST of PCI domain-containing protein vs. Ensembl Yeast
Match: THP1 (Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding [Source:SGD;Acc:S000005433])

HSP 1 Score: 59.6918 bits (143), Expect = 3.826e-10
Identity = 102/420 (24.29%), Postives = 167/420 (39.76%), Query Frame = 3 
Query:  138 SQNGHELA---KQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFD--------YQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVN--SKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDK----NTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFS---VSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFEN------CHRNSVKNKKSILLYLIPVKMLMGIL---AP-ESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCG---IYLILEKLKYIAYRNLFKNVSKAMENHL----IPISVFCDALKFAGVPDI-DMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHL 1283
            SQNG E+A   KQ +  D    D+ L  F  ++  M +  + +K M  + L   NY  D +   A+         YQ  +  LI D    IE           I V  R   F +N   K  S    L   S   ++     + RLFN     +    +T     +R+ ++ + N+L  IYF I    LC  +    +   +   F+   +  Q+ + Y +GR Y+ ++    A      AF++       ++   +N   IL Y+IP  +++G +    P    L +  +  +  + K VR GNI  +   L +N+     C    + ++LEKL  + YRNL K V K+         +P S+    L+ +  P   D       + N I   K    +      L + + N FP L L
Sbjct:   24 SQNGREIAILQKQLTGFD----DKQLETFVEQHPAMPND-TRFKIMCTSFL---NYARDVDPWSAWSSSDLIFEFYQCLINCLINDNAPHIE---------MLIPVATRETEFIINLAGKLDSFHLQLHTRSHQFLSHISSILSRLFNSIKPPRGNASSTNIPGKQRI-LLYLVNKLNNIYFRIESPQLCSNIFKNFQPKSMLAHFNEYQLDQQIEYRYLLGRYYLLNSQVHNAFVQFNEAFQSLLNLPLTNQAITRNGTRILNYMIPTGLILGKMVKWGPLRPFLSQETIDNWSVLYKHVRYGNIQGVSLWLRQNERHL--CARQLLIVLLEKLPMVTYRNLIKTVIKSWTTEWGQNKLPYSLIERVLQLSIGPTFEDPGAQEITIYNGIHSPKNVENVLVTLINLGLLRANCFPQLQL 423
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BLAST of PCI domain-containing protein vs. Ensembl Nematostella
Match: EDO39944 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8I2])

HSP 1 Score: 322.013 bits (824), Expect = 6.044e-107
Identity = 164/399 (41.10%), Postives = 243/399 (60.90%), Query Frame = 3 
Query:   96 TIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLW-----KEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            T+   +  +V  + S+NG   A+  S    HI    L     +     SQ   W      E++  HL+ +  V + ++  A++ Q  ++Q    +F+  +++NW LP++ A+++D+R  A   + +   +    +   G ++  A + I   F  C+ D  ++ + SK+ GM+A+   LFKIYF IN+  LCKPLI AI++  I ++F + H V + ++VGRKY+FD +F  A EYL+FAFE+CHR S KNK++IL+YLIPVKML+G    + +L KY L +F+ ++KSVR GN+   D  L + +AFFI CGIYLILEKLK I YRNLFK V   M+ H +P+  F  ALK   V D+D+ E  CI+ANLI+   IKGY++HQ QKLV+SK NAFP L
Sbjct:    5 TVIQYLQQVVDAMSSRNGDLAAELLSFTHPHIASPRL-----QIPDAQSQCERWFEPPLDELVACHLRAVWAVGNNDYVEAYNAQASVVQAFIKIFQAQKDENWSLPLMSAVTLDIRRFAVKADQQMCQRG---AGKPGDTLEKAAEMIMGCFRVCASDSRSSLDVSKKWGMLALVVHLFKIYFKINKLHLCKPLIRAIDSAPIKDQFKLGHLVAYRFFVGRKYMFDGDFCSAEEYLSFAFEHCHRESPKNKRAILIYLIPVKMLLGNFPKQEVLKKYRLSQFIEVVKSVRQGNLLLFDETLERQQAFFIQCGIYLILEKLKIITYRNLFKKVYLMMKTHQLPLDAFVVALKAMKVDDMDIMEVQCIVANLIYMGYIKGYISHQHQKLVVSKQNAFPPL 395
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BLAST of PCI domain-containing protein vs. Ensembl Medaka
Match: pcid2 (PCI domain containing 2 [Source:NCBI gene;Acc:101155259])

HSP 1 Score: 268.855 bits (686), Expect = 7.305e-86
Identity = 160/399 (40.10%), Postives = 235/399 (58.90%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYF--AINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLM--GILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSL 1277
            +TI   +  I   I +  G   A+  S    H+ +  L   + E          + EM+ AHL     V + +F  A+ +Q  ++      F+  +E+N  LP++ A+++DLR+ A     +   K K      G  +  A + +   F  C+ D+    + SK+ GMM + NQLFKIYF   IN+  LCKPLI AI++  +   +S + +VT+ YYVGRK +FD++F+ A E+L+FAF +CHR+S KNK+ IL+YL+PVKML+  G +    LL KY+L +F  + K+V  GN+  L+  L+K++ FFI CGI+LILEKLK I YRNLFK     ++ H +P+  F  +LK   V D+D+DE  CILANLI+   IKGY++HQ QKLV+SK N FP L
Sbjct:    4 ITINQYLQQIYEAIDNHEGSFCAELLSFKHPHVANPRLQLANPEDKCQQILEPPYDEMVAAHL-CTYAVANHDFVEAYKFQTLVVA-----FQSHKEENA-LPIMSAVTLDLRIFANNAEQQLQKKGKG---HPGEMLEKAAEQLMSCFRVCASDR-AGIDDSKKWGMMFLSNQLFKIYFKLQINKLHLCKPLIRAIDSSNLKNDYSQAQKVTYKYYVGRKAMFDSDFKPAEEFLSFAFHHCHRSSQKNKRMILIYLLPVKMLLFQGHMPTHQLLRKYDLMQFSDVTKAVE-GNLLLLNEALSKHETFFIRCGIFLILEKLKIITYRNLFKKYL-LLKTHQLPLDAFLVSLKMMQVEDVDLDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPL 389
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BLAST of PCI domain-containing protein vs. Planmine SMEST
Match: SMESG000007206.1 (SMESG000007206.1)

HSP 1 Score: 732.25 bits (1889), Expect = 0.000e+0
Identity = 366/404 (90.59%), Postives = 367/404 (90.84%), Query Frame = 3 
Query:   93 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNWFLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHLTSLTITR 1304
            MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFK                                  +DLRLLAFAVNSKTGSKVKDLSRDS SSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNV KAMENHLIPISVFCDALKFAGVPDIDMDET CILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHLTSLTITR
Sbjct:    1 MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGSQFSLWKEMLIAHLKIINYVHDKNFK----------------------------------LDLRLLAFAVNSKTGSKVKDLSRDSRSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVCKAMENHLIPISVFCDALKFAGVPDIDMDETCCILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHLTSLTITR 370
[Close]
BLAST of PCI domain-containing protein vs. Planmine SMEST
Match: SMESG000007339.1 (SMESG000007339.1)

HSP 1 Score: 387.882 bits (995), Expect = 5.630e-134
Identity = 191/298 (64.09%), Postives = 235/298 (78.86%), Query Frame = 3 
Query:  411 AISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFNECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGIAEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKSILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNKNKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFAGVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHLTSLTITR 1304
             ++VDLR LA A++    S+VK  S  +G +M    D + RLF +C  D  +  E+SK++GMMA+CNQLFKI+F I+Q  LCK LI AIENLGI +KFS+  QVT+NYYVGRK +FD+NFQKA E LTFAFENCHR+ VKNK+ IL+YLIPVKML+G    + LL+KYNL EF G++KSVR G++  L++ELN N  FFI+CG+YLILEKLKYIAYRNLFK VS  + +H+I IS F DALKF GV DID+DET CILANLIFENKIKGYLAHQQQKLV+SKTNAFPS+  T++T+TR
Sbjct:    3 VLTVDLRCLAHAMDYGIDSQVKHHS-SAGENMKRVADCLMRLFRKCVSDSRSNVETSKKMGMMALCNQLFKIFFTISQLNLCKSLILAIENLGIIDKFSICQQVTYNYYVGRKCMFDDNFQKANESLTFAFENCHRDYVKNKRLILIYLIPVKMLLGNFPTDKLLVKYNLKEFSGVVKSVRIGDLCNLEAELNINGPFFISCGVYLILEKLKYIAYRNLFKTVSTMIGSHMISISAFSDALKFVGVSDIDIDETECILANLIFENKIKGYLAHQQQKLVMSKTNAFPSISQTTVTVTR 299
The following BLAST results are available for this feature:
BLAST of PCI domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PCID23.535e-10742.53PCI domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
PCID23.535e-10742.53PCI domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
PCID23.535e-10742.53PCI domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
PCID23.055e-10642.42PCI domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
PCID23.055e-10642.42PCI domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of PCI domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
C27F2.102.143e-9440.59PCI domain-containing protein 2 homolog [Source:U... [more]
C27F2.102.143e-9440.59PCI domain-containing protein 2 homolog [Source:U... [more]
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BLAST of PCI domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
PCID25.596e-9638.75gene:FBgn0036184 transcript:FBtr0076102[more]
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BLAST of PCI domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pcid21.403e-9739.49PCI domain containing 2 [Source:NCBI gene;Acc:4925... [more]
pcid21.403e-9739.49PCI domain containing 2 [Source:NCBI gene;Acc:4925... [more]
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BLAST of PCI domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rnf1381.907e-10943.29ring finger protein 138 [Source:Xenbase;Acc:XB-GEN... [more]
rnf1388.835e-10242.03ring finger protein 138 [Source:Xenbase;Acc:XB-GEN... [more]
rnf1381.411e-10042.93ring finger protein 138 [Source:Xenbase;Acc:XB-GEN... [more]
rnf1385.951e-10045.45ring finger protein 138 [Source:Xenbase;Acc:XB-GEN... [more]
rnf1382.643e-9541.52ring finger protein 138 [Source:Xenbase;Acc:XB-GEN... [more]
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BLAST of PCI domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Pcid23.188e-10342.28PCI domain containing 2 [Source:MGI Symbol;Acc:MGI... [more]
Pcid24.571e-927.59PCI domain containing 2 [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of PCI domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5FWP8|PCID2_XENLA4.731e-10943.29PCI domain-containing protein 2 OS=Xenopus laevis ... [more]
sp|Q5JVF3|PCID2_HUMAN1.698e-10642.53PCI domain-containing protein 2 OS=Homo sapiens OX... [more]
sp|Q8BFV2|PCID2_MOUSE2.230e-10242.28PCI domain-containing protein 2 OS=Mus musculus OX... [more]
sp|Q2TBN6|PCID2_BOVIN8.905e-9940.84PCI domain-containing protein 2 OS=Bos taurus OX=9... [more]
sp|Q60YJ7|PCID2_CAEBR8.354e-9841.69PCI domain-containing protein 2 homolog OS=Caenorh... [more]
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BLAST of PCI domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4S2MAW69.521e-13149.10PCI domain-containing protein OS=Opisthorchis feli... [more]
A0A504YG574.554e-12446.73PCI domain-containing protein 2 OS=Fasciola gigant... [more]
A0A564YH555.841e-12047.47PCI domain-containing protein OS=Hymenolepis dimin... [more]
A0A5K3EQ901.439e-11948.23Uncharacterized protein OS=Mesocestoides corti OX=... [more]
G4VC101.540e-11946.84PCI domain-containing protein OS=Schistosoma manso... [more]
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BLAST of PCI domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pcid25.451e-9740.25PCI domain containing 2 [Source:NCBI gene;Acc:1030... [more]
pcid25.451e-9740.25PCI domain containing 2 [Source:NCBI gene;Acc:1030... [more]
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BLAST of PCI domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pcid24.411e-10345.77PCI domain containing 2 [Source:NCBI gene;Acc:4925... [more]
pcid21.063e-5642.65PCI domain containing 2 [Source:NCBI gene;Acc:4925... [more]
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BLAST of PCI domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
YJR084W1.234e-1420.00Protein that forms a complex with Thp3p; may have ... [more]
THP13.826e-1024.29Nuclear pore-associated protein; component of TREX... [more]
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BLAST of PCI domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO399446.044e-10741.10Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of PCI domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pcid27.305e-8640.10PCI domain containing 2 [Source:NCBI gene;Acc:1011... [more]
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BLAST of PCI domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000007206.10.000e+090.59SMESG000007206.1[more]
SMESG000007339.15.630e-13464.09SMESG000007339.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30007345 ID=SMED30007345|Name=PCI domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1334bp
ATTTTGATTAGGAATATTTTATTTTACGTTATAATATTTATTTAATCATA
TTTGTTGTTTTAATATTTAAATATAATATAGAAGATTTCGAAATGACAAT
TGAATCACTTATTGCTAATATTGTTAGAAATATAAGAAGTCAAAATGGCC
ATGAATTAGCCAAACAATATAGCTTGAATGATAGCCATATTCAAGATCAA
ACATTAATTGGATTTCATTCAGAATATGTCAAAATGGGTTCTCAATTTAG
CCTGTGGAAAGAAATGCTCATTGCCCATTTAAAAATTATAAATTATGTTC
ACGATAAAAATTTTAAATGTGCTTTCGATTACCAGATACAATTGATACAG
TTGATATTCGACTTGTTCAAGCAAATAGAAGAAGACAATTGGTTTTTGCC
TGTTGTCTATGCTATTTCAGTAGATTTAAGACTGCTCGCATTCGCAGTGA
ATAGTAAAACTGGATCCAAAGTAAAAGATCTCAGTCGTGATTCCGGAAGC
AGCATGACAGTTGCGGTTGATTATATCCGAAGATTATTCAATGAATGTAG
TTTTGACAAGAACACAACTTTTGAATCTTCCAAACGACTCGGAATGATGG
CAATGTGTAACCAACTTTTTAAGATATATTTTGCTATCAACCAATTTACT
TTATGCAAGCCGTTAATTAACGCGATTGAAAATCTGGGAATTGCAGAGAA
ATTTAGCGTTTCCCATCAAGTAACATTCAATTATTACGTGGGGCGGAAAT
ACATATTCGATAACAATTTCCAAAAGGCTGTCGAATATTTAACTTTTGCT
TTCGAAAATTGTCATAGAAATTCTGTCAAAAACAAGAAATCAATCCTACT
ATATCTTATTCCCGTTAAGATGCTAATGGGAATTTTGGCACCTGAAAGTC
TTTTAATGAAATATAATTTACCAGAATTTGTTGGTATCATGAAAAGCGTC
AGAAATGGAAATATAAGTTTTCTTGATTCAGAATTAAATAAAAACAAAGC
TTTTTTTATTAATTGCGGTATTTATTTAATTCTGGAGAAGTTGAAATATA
TTGCCTATCGAAACCTGTTTAAAAATGTGTCGAAGGCAATGGAGAATCAT
TTAATCCCGATTTCAGTGTTTTGTGATGCTTTGAAATTCGCTGGGGTTCC
AGACATTGACATGGACGAAACGAGCTGCATTTTAGCAAATCTTATTTTCG
AAAATAAAATTAAAGGATATCTGGCTCATCAACAACAAAAATTAGTTATT
AGCAAAACAAACGCATTTCCGTCATTACATTTAACAAGCTTAACGATTAC
GCGATAGTTCCTGTAATACGATGAATAAATTTAC
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protein sequence of SMED30007345-orf-1

>SMED30007345-orf-1 ID=SMED30007345-orf-1|Name=SMED30007345-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=405bp
MTIESLIANIVRNIRSQNGHELAKQYSLNDSHIQDQTLIGFHSEYVKMGS
QFSLWKEMLIAHLKIINYVHDKNFKCAFDYQIQLIQLIFDLFKQIEEDNW
FLPVVYAISVDLRLLAFAVNSKTGSKVKDLSRDSGSSMTVAVDYIRRLFN
ECSFDKNTTFESSKRLGMMAMCNQLFKIYFAINQFTLCKPLINAIENLGI
AEKFSVSHQVTFNYYVGRKYIFDNNFQKAVEYLTFAFENCHRNSVKNKKS
ILLYLIPVKMLMGILAPESLLMKYNLPEFVGIMKSVRNGNISFLDSELNK
NKAFFINCGIYLILEKLKYIAYRNLFKNVSKAMENHLIPISVFCDALKFA
GVPDIDMDETSCILANLIFENKIKGYLAHQQQKLVISKTNAFPSLHLTSL
TITR*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
GO:0005575cellular_component
GO:0070390transcription export complex 2
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR036388WH-like_DNA-bd_sf
IPR000717PCI_dom
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0003690double-stranded DNA binding
GO:0003723RNA binding
Vocabulary: biological process
TermDefinition
GO:0000973posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006368transcription elongation from RNA polymerase II promoter
GO:0016973poly(A)+ mRNA export from nucleus
GO:0043066negative regulation of apoptotic process
GO:0043488regulation of mRNA stability
GO:0045579positive regulation of B cell differentiation
GO:0045893positive regulation of transcription, DNA-templated
GO:0048536spleen development
GO:0071033nuclear retention of pre-mRNA at the site of transcription
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:2000117negative regulation of cysteine-type endopeptidase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000717Proteasome component (PCI) domainPFAMPF01399PCIcoord: 279..388
e-value: 4.3E-14
score: 52.9
IPR000717Proteasome component (PCI) domainPROSITEPS50250PCIcoord: 210..391
score: 12.584
NoneNo IPR availableGENE3DG3DSA:1.25.40.570coord: 198..327
e-value: 1.7E-39
score: 136.6
NoneNo IPR availablePANTHERPTHR12732UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAININGcoord: 2..396
NoneNo IPR availablePANTHERPTHR12732:SF0PCI DOMAIN-CONTAINING PROTEIN 2coord: 2..396
IPR036388Winged helix-like DNA-binding domain superfamilyGENE3DG3DSA:1.10.10.10coord: 328..398
e-value: 4.4E-27
score: 95.8