Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30007298 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925]) HSP 1 Score: 204.912 bits (520), Expect = 8.271e-58 Identity = 149/463 (32.18%), Postives = 237/463 (51.19%), Query Frame = 2
Query: 164 VNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRK--HEDLSVEIFSMLLEH-IKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEID----------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIE-TVIGQKVYDPKIWFSS-EFISKVCDYHIWNIMS------KYTSGIVERIQERKLYKIFDQIQ-----------IELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNK 1453
+ND +HG I+L + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L+ L ++ E++IS+ DV CV+IA LCHDLGHGP+SH ++ F K HE SV M+ EH I S+ + + ++ GL + I IK I+G + ++ + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F R+ + + + RD+E+ +++D+F+ R+ LHR YQHK II+ M DA + ++ IE T G K Y E +K+ D I+ K I+++I+ R L+K + Q E P L ++K K +DF + + + +Q + NP+ V+FY K P + + + L+ K E ++ ++ + + K
Sbjct: 118 INDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHAL---GEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSV----MMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKA-------DDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEK---NPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRK 560
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925]) HSP 1 Score: 204.912 bits (520), Expect = 1.438e-57 Identity = 149/463 (32.18%), Postives = 237/463 (51.19%), Query Frame = 2
Query: 164 VNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRK--HEDLSVEIFSMLLEH-IKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEID----------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIE-TVIGQKVYDPKIWFSS-EFISKVCDYHIWNIMS------KYTSGIVERIQERKLYKIFDQIQ-----------IELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNK 1453
+ND +HG I+L + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L+ L ++ E++IS+ DV CV+IA LCHDLGHGP+SH ++ F K HE SV M+ EH I S+ + + ++ GL + I IK I+G + ++ + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F R+ + + + RD+E+ +++D+F+ R+ LHR YQHK II+ M DA + ++ IE T G K Y E +K+ D I+ K I+++I+ R L+K + Q E P L ++K K +DF + + + +Q + NP+ V+FY K P + + + L+ K E ++ ++ + + K
Sbjct: 118 INDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHAL---GEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSV----MMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKA-------DDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEK---NPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRK 560
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925]) HSP 1 Score: 204.912 bits (520), Expect = 1.438e-57 Identity = 149/463 (32.18%), Postives = 237/463 (51.19%), Query Frame = 2
Query: 164 VNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRK--HEDLSVEIFSMLLEH-IKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEID----------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIE-TVIGQKVYDPKIWFSS-EFISKVCDYHIWNIMS------KYTSGIVERIQERKLYKIFDQIQ-----------IELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNK 1453
+ND +HG I+L + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L+ L ++ E++IS+ DV CV+IA LCHDLGHGP+SH ++ F K HE SV M+ EH I S+ + + ++ GL + I IK I+G + ++ + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F R+ + + + RD+E+ +++D+F+ R+ LHR YQHK II+ M DA + ++ IE T G K Y E +K+ D I+ K I+++I+ R L+K + Q E P L ++K K +DF + + + +Q + NP+ V+FY K P + + + L+ K E ++ ++ + + K
Sbjct: 118 INDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHAL---GEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSV----MMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKA-------DDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEK---NPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRK 560
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925]) HSP 1 Score: 196.052 bits (497), Expect = 3.579e-56 Identity = 112/282 (39.72%), Postives = 168/282 (59.57%), Query Frame = 2
Query: 164 VNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRK--HEDLSVEIFSMLLEHIKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEID----------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL 970
+ND +HG I+L + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L+ L ++ E++IS+ DV CV+IA LCHDLGHGP+SH ++ F K HE SV +F L I S+ + + ++ GL + I IK I+G + ++ + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F R+ + + + RD+E+ +++D+F+ R+ LHR YQHK II+ M DA
Sbjct: 94 INDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHAL---GEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHL---INSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAF 366
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925]) HSP 1 Score: 197.593 bits (501), Expect = 3.401e-55 Identity = 113/283 (39.93%), Postives = 169/283 (59.72%), Query Frame = 2
Query: 164 VNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRK--HEDLSVEIFSMLLEH-IKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEID----------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL 970
+ND +HG I+L + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L+ L ++ E++IS+ DV CV+IA LCHDLGHGP+SH ++ F K HE SV M+ EH I S+ + + ++ GL + I IK I+G + ++ + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F R+ + + + RD+E+ +++D+F+ R+ LHR YQHK II+ M DA
Sbjct: 118 INDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHAL---GEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSV----MMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAF 390
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Celegans
Match: ZK177.8 (pep chromosome:WBcel235:II:5509032:5513775:-1 gene:WBGene00022673.1 transcript:ZK177.8b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK177.8) HSP 1 Score: 151.754 bits (382), Expect = 2.602e-39 Identity = 100/308 (32.47%), Postives = 161/308 (52.27%), Query Frame = 2
Query: 137 QSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLE--HIKSDETQKIKDKIGLKKNTIDLIKRIILGN-FD-KEID------------------------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIA--KKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL 970
QS +P+ +ND V+G +K+P I ++ID+ +FQRLRH++Q G Y VY + +SRF HS+GTF LA L+ +L++ + I++ D+ C +AAL HD+GHGP+SH ++ F KHED+S+ I ++ IKS+ + + ++ LI +I G FD +++D ++ FLF++V+N +G DVDK DYL RDS G ++R+ + +R+ S + +A + I + + R LH YQHK V+ +E + DAL
Sbjct: 4 QSLEPKH-IINDNVYGTVKVPRPIDKLIDTVEFQRLRHLKQTGLVYLVYPNCEHSRFVHSLGTFSLAYALVDKLRH---SQPSLNITESDLICTSVAALLHDVGHGPFSHLFDGEFAKRNGSRFKHEDMSILIIKKIMNKPEIKSEFACILGETDEEYAKSVTLITELISGKPFDFQDMDGFKDLPADVREETVKNEWAIIGCGPEKSFLFDVVSNSYNGHDVDKMDYLLRDSKASGVGITFSESTLERLFNHVRVVIDPNSGLKRIAYSIKCIGDLKAIGDSRQELHSKVYQHKAVRFMETLMVDAL 307
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Celegans
Match: ZK177.8 (pep chromosome:WBcel235:II:5509028:5511208:-1 gene:WBGene00022673.1 transcript:ZK177.8b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK177.8) HSP 1 Score: 151.754 bits (382), Expect = 2.602e-39 Identity = 100/308 (32.47%), Postives = 161/308 (52.27%), Query Frame = 2
Query: 137 QSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLE--HIKSDETQKIKDKIGLKKNTIDLIKRIILGN-FD-KEID------------------------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIA--KKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL 970
QS +P+ +ND V+G +K+P I ++ID+ +FQRLRH++Q G Y VY + +SRF HS+GTF LA L+ +L++ + I++ D+ C +AAL HD+GHGP+SH ++ F KHED+S+ I ++ IKS+ + + ++ LI +I G FD +++D ++ FLF++V+N +G DVDK DYL RDS G ++R+ + +R+ S + +A + I + + R LH YQHK V+ +E + DAL
Sbjct: 4 QSLEPKH-IINDNVYGTVKVPRPIDKLIDTVEFQRLRHLKQTGLVYLVYPNCEHSRFVHSLGTFSLAYALVDKLRH---SQPSLNITESDLICTSVAALLHDVGHGPFSHLFDGEFAKRNGSRFKHEDMSILIIKKIMNKPEIKSEFACILGETDEEYAKSVTLITELISGKPFDFQDMDGFKDLPADVREETVKNEWAIIGCGPEKSFLFDVVSNSYNGHDVDKMDYLLRDSKASGVGITFSESTLERLFNHVRVVIDPNSGLKRIAYSIKCIGDLKAIGDSRQELHSKVYQHKAVRFMETLMVDAL 307
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Celegans
Match: ZK177.8 (pep chromosome:WBcel235:II:5509032:5513748:-1 gene:WBGene00022673.1 transcript:ZK177.8a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK177.8) HSP 1 Score: 151.369 bits (381), Expect = 4.144e-39 Identity = 100/308 (32.47%), Postives = 161/308 (52.27%), Query Frame = 2
Query: 137 QSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLE--HIKSDETQKIKDKIGLKKNTIDLIKRIILGN-FD-KEID------------------------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIA--KKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL 970
QS +P+ +ND V+G +K+P I ++ID+ +FQRLRH++Q G Y VY + +SRF HS+GTF LA L+ +L++ + I++ D+ C +AAL HD+GHGP+SH ++ F KHED+S+ I ++ IKS+ + + ++ LI +I G FD +++D ++ FLF++V+N +G DVDK DYL RDS G ++R+ + +R+ S + +A + I + + R LH YQHK V+ +E + DAL
Sbjct: 38 QSLEPKH-IINDNVYGTVKVPRPIDKLIDTVEFQRLRHLKQTGLVYLVYPNCEHSRFVHSLGTFSLAYALVDKLRH---SQPSLNITESDLICTSVAALLHDVGHGPFSHLFDGEFAKRNGSRFKHEDMSILIIKKIMNKPEIKSEFACILGETDEEYAKSVTLITELISGKPFDFQDMDGFKDLPADVREETVKNEWAIIGCGPEKSFLFDVVSNSYNGHDVDKMDYLLRDSKASGVGITFSESTLERLFNHVRVVIDPNSGLKRIAYSIKCIGDLKAIGDSRQELHSKVYQHKAVRFMETLMVDAL 341
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Fly
Match: fal (gene:FBgn0028380 transcript:FBtr0347258) HSP 1 Score: 119.013 bits (297), Expect = 5.411e-29 Identity = 85/283 (30.04%), Postives = 144/283 (50.88%), Query Frame = 2
Query: 161 FVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLG-FGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWE----HAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDK--KRMFLFEIVANKCSGLDVDKFDYLCRDS--IYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIV 982
+ D VHG+I+L +I+EI++ P FQRL+H+ QLG + + A + R++H +G + A + ++ ++ + E ++ D + VEIAAL HD+GHGP SH WE H FD HE+ ++ + + + E ++D G + + LIK +ILG+ + ++F+IV N+ GLDVDK+DYL RD+ + S + D+ FL+ D + R + ++ +F R LLH YQ+ ++ +F + I
Sbjct: 2 LIEDEVHGVIELSSHIQEIVEHPLFQRLKHVHQLGLLPWAIDKKADHKRYDHCLGAYKSAQDHLRAIERNSHY--EPKLPDWCRQAVEIAALLHDIGHGPMSHAWELVTHHEFD--------HEENAMACVDKIFKDALNQELVSLRDDGGGR--GVQLIKALILGSSENLPFPMLGHTYIFDIVHNRRCGLDVDKWDYLRRDNKRLKILSSAEMDFDDV-----FLQARISPDGQRIEYRYADYHRVYRLFEARSLLHVKAYQYPLTCAMDVIFVSVVQRIA 267
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Fly
Match: fal (gene:FBgn0028380 transcript:FBtr0290284) HSP 1 Score: 119.013 bits (297), Expect = 5.411e-29 Identity = 85/283 (30.04%), Postives = 144/283 (50.88%), Query Frame = 2
Query: 161 FVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLG-FGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWE----HAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDK--KRMFLFEIVANKCSGLDVDKFDYLCRDS--IYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIV 982
+ D VHG+I+L +I+EI++ P FQRL+H+ QLG + + A + R++H +G + A + ++ ++ + E ++ D + VEIAAL HD+GHGP SH WE H FD HE+ ++ + + + E ++D G + + LIK +ILG+ + ++F+IV N+ GLDVDK+DYL RD+ + S + D+ FL+ D + R + ++ +F R LLH YQ+ ++ +F + I
Sbjct: 2 LIEDEVHGVIELSSHIQEIVEHPLFQRLKHVHQLGLLPWAIDKKADHKRYDHCLGAYKSAQDHLRAIERNSHY--EPKLPDWCRQAVEIAALLHDIGHGPMSHAWELVTHHEFD--------HEENAMACVDKIFKDALNQELVSLRDDGGGR--GVQLIKALILGSSENLPFPMLGHTYIFDIVHNRRCGLDVDKWDYLRRDNKRLKILSSAEMDFDDV-----FLQARISPDGQRIEYRYADYHRVYRLFEARSLLHVKAYQYPLTCAMDVIFVSVVQRIA 267
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Fly
Match: fal (gene:FBgn0028380 transcript:FBtr0321324) HSP 1 Score: 119.013 bits (297), Expect = 5.411e-29 Identity = 85/283 (30.04%), Postives = 144/283 (50.88%), Query Frame = 2
Query: 161 FVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLG-FGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWE----HAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDK--KRMFLFEIVANKCSGLDVDKFDYLCRDS--IYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIV 982
+ D VHG+I+L +I+EI++ P FQRL+H+ QLG + + A + R++H +G + A + ++ ++ + E ++ D + VEIAAL HD+GHGP SH WE H FD HE+ ++ + + + E ++D G + + LIK +ILG+ + ++F+IV N+ GLDVDK+DYL RD+ + S + D+ FL+ D + R + ++ +F R LLH YQ+ ++ +F + I
Sbjct: 2 LIEDEVHGVIELSSHIQEIVEHPLFQRLKHVHQLGLLPWAIDKKADHKRYDHCLGAYKSAQDHLRAIERNSHY--EPKLPDWCRQAVEIAALLHDIGHGPMSHAWELVTHHEFD--------HEENAMACVDKIFKDALNQELVSLRDDGGGR--GVQLIKALILGSSENLPFPMLGHTYIFDIVHNRRCGLDVDKWDYLRRDNKRLKILSSAEMDFDDV-----FLQARISPDGQRIEYRYADYHRVYRLFEARSLLHVKAYQYPLTCAMDVIFVSVVQRIA 267
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Zebrafish
Match: samhd1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:553453]) HSP 1 Score: 211.46 bits (537), Expect = 2.824e-60 Identity = 155/482 (32.16%), Postives = 246/482 (51.04%), Query Frame = 2
Query: 128 QLSQ-SEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAF--DNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEI-----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEI-----VHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSG--------IVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEI-KSK---------LKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETE 1462
+LSQ S +P F ND +HG I+L + ID+PQFQRLRHI+QLG Y V+ A ++RFEHSIG +LA L+K L ++ E+ I+ +D+ CV+IA LCHDLGHGP+SH ++ F + KHE SV++F L+E + E + + L ++ I IK I G + + ++ FL+E+VANK +G+DVDK+DY RD + G N D +R L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M +A + + R I + I E SK+ D+ I+ Y+SG I++ I R+LYK Q E N + +K +E+ +SK +DF + + + ++ + NP+ +V+FY K +P K ++ + L+ + E ++ ++ + +K E
Sbjct: 85 KLSQISTEPMKVF-NDPIHGHIELHPLLLHFIDTPQFQRLRHIKQLGGTYLVFPGASHNRFEHSIGVGYLAGCLVKAL---NERQPELFITKQDILCVQIAGLCHDLGHGPFSHMFDGMFIPKARPADKWKHEIASVQMFDHLVE-VNGLEAVMLHHGMRLPEDLI-FIKEQIAGPLESAVLDQSQWPYKGRPVEKSFLYEVVANKRNGIDVDKWDYFARDCYHLGIQNN---FDYQRFLRFARVCEVKGRKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITEAFLKADPHIQIQGSSGRIFTISSAIE----------DMEAYSKLTDHIFEQIL--YSSGPELSEARAILQNIICRRLYKCVGQTTSETNVDVSQEKLLDWAKELARSKPTGTEGNLIAEDFVVSVIHMDYGMKEK---NPINNVHFYCKNDPTKAIKIHKKQVSKLLPERFAEQLIRVYCKKTDDKSLE 542
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Zebrafish
Match: si:ch73-236c18.9 (si:ch73-236c18.9 [Source:ZFIN;Acc:ZDB-GENE-121214-125]) HSP 1 Score: 201.83 bits (512), Expect = 1.983e-57 Identity = 145/455 (31.87%), Postives = 234/455 (51.43%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWE-------------HAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILG--NFDKEIDKK-----RMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL---NEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQI--------ELNPNFQG--QKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIF 1432
ND +HG I L + +I D+PQFQRLRH++QLG Y VY A ++RFEHSIG +LA L+K L D E++I+ +D CV+IA LCHDLGHGP SH ++ ++ E KHE +SV +F +++ + +++ + GL N + IK +I G D E K + FL+EIVANK +G+DVDK+DY RD + G N D R+L F R+ + H+ RD+E +++D+F R+ LHR YQHK IIE MF +AL + +H ED ++++ K + + E ++ N+ K + I+++I RKL K + ++ EL +++ +K + ++ P+ V ++ + NP+ V FY+K+ P + + E+ L + K +E ++ ++
Sbjct: 64 NDPIHGHIALHPLLVKITDTPQFQRLRHLKQLGGTYLVYPGASHNRFEHSIGVAYLAGRLVKSLH---DNQPELKITKQDFLCVQIAGLCHDLGHGPLSHVFDALVIPEAKKIKTRKGLPDDIPESWKHEQMSVLMFDSIVKSL----NEEVLREHGLTDNDVIFIKELIEGAKASDNEWPYKGRNVEKSFLYEIVANKQNGIDVDKWDYFARDCHHLGIRNS---FDHLRLLKFARVCVVNGRKHICFRDKEADNVYDMFRTRYTLHRQAYQHKIGNIIEDMFAEALLLADRDLH-EDRPADMLKISEAIKSVEDYSKLTDEIFEQILSSTSPNL--KESRDILDKIMRRKLPKFIGETRLTKKIKSMEELKNSWKAAIEKYKPTDPNVNLTTEELPVYVVDLDHGMKDK---NPIEHVYFYSKRKPNEASTIEDYQLSSFLPNKFNEELVRVY 502
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Zebrafish
Match: si:ch73-236c18.8 (si:ch73-236c18.8 [Source:ZFIN;Acc:ZDB-GENE-121214-113]) HSP 1 Score: 201.06 bits (510), Expect = 4.390e-57 Identity = 148/458 (32.31%), Postives = 235/458 (51.31%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWE-------------HAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILG--NFDKEI-----DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMS------KYTSGIVERIQERKLYKIFDQIQI--------ELNPNFQGQKGHIDLQEIKSKL--KDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIF 1432
ND +HG I L + +I D+PQFQRLRH++QLG Y VY A ++RFEHSIG +LA L+K L D E++I+ +D CV+IA LCHDLGHGP SH ++ ++ E KHE +SV +F +++ + +++ + GL N + IK +I G D E + ++ FL+EIVANK +G+DVDK+DY RD + G N D R+L F R+ + H+ RD+E +++D+F R+ LHR YQHK IIE MF +AL ++ + D L E + + S E SK+ D I+S K + I+++I RKL K ++++ EL +++ + L ++ P+ V ++ + NP+ V FY+K+ P + + E+ L + K +E ++ ++
Sbjct: 64 NDPIHGHIALHPLLVKITDTPQFQRLRHLKQLGGTYLVYPGASHNRFEHSIGVAYLAGRLVKSLH---DNQPELKITKQDFLCVQIAGLCHDLGHGPLSHVFDVLVIPEVKKIKKLKGLPDDIPESWKHEQMSVLMFDSIVKSL----NEEVLREHGLTDNDVIFIKELIEGAKASDNEWPYQGRNVEKSFLYEIVANKQNGIDVDKWDYFARDCHHLGIRNS---FDHLRLLKFARVCVVNGRKHICFRDKEADNVYDMFRTRYTLHRQAYQHKIANIIEDMFAEAL--LLADRD----LHEKKPADMLKISEAIKSVEDYSKLTDEIFEQILSSTSPNLKESKDILDKIMRRKLPKFIREVRLTVKNMSKEELKNSWKAAVKTYKPTDPTVTLTAEELPVYVVDLDHGMKDK---NPIERVYFYSKRKPNEASTIEDYQLSSFLPKKFNEELVRVY 502
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574]) HSP 1 Score: 213.386 bits (542), Expect = 8.984e-62 Identity = 151/480 (31.46%), Postives = 239/480 (49.79%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEID------------------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEI-----VHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCD---YHIW---NIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQ---------EIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLK 1483
ND +HG I+L + IID+P+FQRLR+I+QLG Y+V+ A ++RFEHSIG +LA L++ L ++ E++I+ D+ CV+IA LCHDLGHGP+SH ++ F R KHE SV +F L IKS+ +++ + GL + + IK I G E + +++ FL+EIVANK +G+DVDK+DY RD + G N D KR L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M DA + + D I + V +K+ D +HI N K I+ +++ R+LYK Q +N + + + DL +++ +DF + + + ++ + NP+ +V FY K +P K + + L+ K E ++ ++ + K ER L K
Sbjct: 5 NDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALH---ERQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHL---IKSNGLEEVMKEYGLCLPDDLTFIKEQIAGPLSSEDEQQFNSSQNSSSWPYRGRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVGSKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVA----------YTKLTDNIYHHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPVRINTDLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRVYCK----KTDERSLEAAK 458
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574]) HSP 1 Score: 212.231 bits (539), Expect = 1.032e-61 Identity = 149/475 (31.37%), Postives = 235/475 (49.47%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEID-------------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEI-----VHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIW---NIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQK------------GHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLK 1483
ND +HG I+L + IID+P+FQRLR+I+QLG Y+V+ A ++RFEHSIG +LA L++ L ++ E++I+ D+ CV+IA LCHDLGHGP+SH ++ F R KHE SV +F L IKS+ +++ + GL + + IK I G E D +++ FL+EIVANK +G+DVDK+DY RD + G N D KR L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M DA + + D I + V K ++ +HI N K I+ +++ R+LYK Q +N + + +++ +DF + + + ++ + NP+ +V FY K +P K + + L+ K E ++ ++ + K ER L K
Sbjct: 5 NDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALH---ERQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHL---IKSNGLEEVMKEYGLCLPDDLTFIKEQIAGPLSSEDDAASFSTWYIFCRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVGSKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVAYTK-------LTDNIYHHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPDEYDTLPADLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRVYCK----KTDERSLEAAK 456
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574]) HSP 1 Score: 213.772 bits (543), Expect = 1.596e-61 Identity = 149/473 (31.50%), Postives = 236/473 (49.89%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEIDKK--------RMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEI-----VHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCD---YHIW---NIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQK------------GHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLK 1483
ND +HG I+L + IID+P+FQRLR+I+QLG Y+V+ A ++RFEHSIG +LA L++ L ++ E++I+ D+ CV+IA LCHDLGHGP+SH ++ F R KHE SV +F L IKS+ +++ + GL + + IK I G E +++ + FL+EIVANK +G+DVDK+DY RD + G N D KR L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M DA + + D I + V +K+ D +HI N K I+ +++ R+LYK Q +N + + +++ +DF + + + ++ + NP+ +V FY K +P K + + L+ K E ++ ++ + K ER L K
Sbjct: 30 NDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALH---ERQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHL---IKSNGLEEVMKEYGLCLPDDLTFIKEQIAGPLSSEDEQQFNSSRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVGSKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVA----------YTKLTDNIYHHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPDEYDTLPADLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRVYCK----KTDERSLEAAK 476
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574]) HSP 1 Score: 208.764 bits (530), Expect = 5.061e-60 Identity = 149/484 (30.79%), Postives = 236/484 (48.76%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEIDKK-------------------RMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEI-----VHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCD---YHIW---NIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQK------------GHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLK 1483
ND +HG I+L + IID+P+FQRLR+I+QLG Y+V+ A ++RFEHSIG +LA L++ L ++ E++I+ D+ CV+IA LCHDLGHGP+SH ++ F R KHE SV +F L IKS+ +++ + GL + + IK I G E +++ + FL+EIVANK +G+DVDK+DY RD + G N D KR L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M DA + + D I + V +K+ D +HI N K I+ +++ R+LYK Q +N + + +++ +DF + + + ++ + NP+ +V FY K +P K + + L+ K E ++ ++ + K ER L K
Sbjct: 5 NDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALH---ERQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHL---IKSNGLEEVMKEYGLCLPDDLTFIKEQIAGPLSSEDEQQFNSMDPIYKNWPYRGRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVGSKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVA----------YTKLTDNIYHHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPDEYDTLPADLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRVYCK----KTDERSLEAAK 462
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574]) HSP 1 Score: 209.92 bits (533), Expect = 5.795e-60 Identity = 149/484 (30.79%), Postives = 242/484 (50.00%), Query Frame = 2
Query: 110 ANYMESQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEI-----VHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCD---YHIW---NIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQK------------GHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLK 1483
+++++ Q++ + ND +HG I+L + IID+P+FQRLR+I+QLG Y+V+ A ++RFEHSIG +LA L++ L ++ E++I+ D+ CV+IA LCHDLGHGP+SH ++ F R KHE SV +F L IKS+ +++ + GL + + IK I + +K FL+EIVANK +G+DVDK+DY RD + G N D KR L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M DA + + D I + V +K+ D +HI N K I+ +++ R+LYK Q +N + + +++ +DF + + + ++ + NP+ +V FY K +P K + + L+ K E ++ ++ + K ER L K
Sbjct: 34 SDFLKEQITVIGILGVSVFNDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALH---ERQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHL---IKSNGLEEVMKEYGLCLPDDLTFIKEQIWPYRGRTEEKS--FLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVGSKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVA----------YTKLTDNIYHHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPDEYDTLPADLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRVYCK----KTDERSLEAAK 489
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Match: Samhd1 (SAM domain and HD domain, 1 [Source:MGI Symbol;Acc:MGI:1927468]) HSP 1 Score: 202.986 bits (515), Expect = 5.217e-57 Identity = 149/477 (31.24%), Postives = 236/477 (49.48%), Query Frame = 2
Query: 128 QLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEI----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAK-----KSD------MWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCD------YHIWNIMSKYTSGIVERIQERKLYKIFDQIQ----------IELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTE 1438
QLSQS ND +HG I+ + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L++ L ++ E++IS+ D+ CV+IA LCHDLGHGP+SH ++ F + KHE S+E+F L + S+E + + GL + I IK I+G + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F RI + K D + H+ R++E+ +++D+F+ R+ LHR YQHK +I+ M DA + D E+ T G+K E +K+ D H + I+ I+ R LYK + Q E P + +++ K +DF + + + ++ + NP+ V+FY K N + +E + L+ K E ++ ++ +
Sbjct: 118 QLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRAL---AEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHL---VNSNELKLVMKNYGLVPEEDITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIMITDAFLKA----DPYVEITGTA-GKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVINVDYGMEDK---NPIDRVHFYCKSNSKQAVRINKEQVSQLLPEKFAEQLIRVYCK 577
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Match: Samhd1 (SAM domain and HD domain, 1 [Source:MGI Symbol;Acc:MGI:1927468]) HSP 1 Score: 202.986 bits (515), Expect = 6.678e-57 Identity = 149/477 (31.24%), Postives = 236/477 (49.48%), Query Frame = 2
Query: 128 QLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEI----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAK-----KSD------MWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCD------YHIWNIMSKYTSGIVERIQERKLYKIFDQIQ----------IELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTE 1438
QLSQS ND +HG I+ + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L++ L ++ E++IS+ D+ CV+IA LCHDLGHGP+SH ++ F + KHE S+E+F L + S+E + + GL + I IK I+G + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F RI + K D + H+ R++E+ +++D+F+ R+ LHR YQHK +I+ M DA + D E+ T G+K E +K+ D H + I+ I+ R LYK + Q E P + +++ K +DF + + + ++ + NP+ V+FY K N + +E + L+ K E ++ ++ +
Sbjct: 138 QLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRAL---AEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHL---VNSNELKLVMKNYGLVPEEDITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIMITDAFLKA----DPYVEITGTA-GKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVINVDYGMEDK---NPIDRVHFYCKSNSKQAVRINKEQVSQLLPEKFAEQLIRVYCK 597
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Match: Samhd1 (SAM domain and HD domain, 1 [Source:MGI Symbol;Acc:MGI:1927468]) HSP 1 Score: 202.986 bits (515), Expect = 8.225e-57 Identity = 149/477 (31.24%), Postives = 236/477 (49.48%), Query Frame = 2
Query: 128 QLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEI----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAK-----KSD------MWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCD------YHIWNIMSKYTSGIVERIQERKLYKIFDQIQ----------IELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTE 1438
QLSQS ND +HG I+ + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L++ L ++ E++IS+ D+ CV+IA LCHDLGHGP+SH ++ F + KHE S+E+F L + S+E + + GL + I IK I+G + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F RI + K D + H+ R++E+ +++D+F+ R+ LHR YQHK +I+ M DA + D E+ T G+K E +K+ D H + I+ I+ R LYK + Q E P + +++ K +DF + + + ++ + NP+ V+FY K N + +E + L+ K E ++ ++ +
Sbjct: 138 QLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRAL---AEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHL---VNSNELKLVMKNYGLVPEEDITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIMITDAFLKA----DPYVEITGTA-GKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVINVDYGMEDK---NPIDRVHFYCKSNSKQAVRINKEQVSQLLPEKFAEQLIRVYCK 597
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Match: Samhd1 (SAM domain and HD domain, 1 [Source:MGI Symbol;Acc:MGI:1927468]) HSP 1 Score: 199.904 bits (507), Expect = 3.508e-56 Identity = 146/459 (31.81%), Postives = 227/459 (49.46%), Query Frame = 2
Query: 128 QLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEI----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAK-----KSD------MWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCD------YHIWNIMSKYTSGIVERIQERKLYKIFDQIQ----------IELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESL 1384
QLSQS ND +HG I+ + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L++ L ++ E++IS+ D+ CV+IA LCHDLGHGP+SH ++ F + KHE S+E+F L + S+E + + GL + I IK I+G + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F RI + K D + H+ R++E+ +++D+F+ R+ LHR YQHK +I+ M DA + D E+ T G+K E +K+ D H + I+ I+ R LYK + Q E P + +++ K +DF + + + ++ + NP+ V+FY K N + +E +
Sbjct: 138 QLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRAL---AEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHL---VNSNELKLVMKNYGLVPEEDITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIMITDAFLKA----DPYVEITGTA-GKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVINVDYGMEDK---NPIDRVHFYCKSNSKQAVRINKEQV 579
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q5ZJL9|SAMH1_CHICK (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Gallus gallus OX=9031 GN=SAMHD1 PE=2 SV=2) HSP 1 Score: 223.016 bits (567), Expect = 1.083e-63 Identity = 156/469 (33.26%), Postives = 245/469 (52.24%), Query Frame = 2
Query: 125 SQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEI----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKY------TSGIVERIQERKLYKIFDQIQIE------------LNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTE 1438
+QL Q+ D F ND VHG I++ + IID+PQFQRLR+I+QLG YFV+ A ++RFEHS+G +LA L+++LK ++ E++I+ D+ CVEIA LCHDLGHGP+SH ++ F + KHE SVE+F L I S++ ++I + GL + I IK I G D+ K++ FL+EIVANK +G+DVDK+DY RD + G N D +R++ F R+ + + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M +A + D + IE G+ + E +K+ D I+ I+ +I+ R+LYK + Q E L + K D +++ +DF + V + ++ + NP+ +V FY K +P K +E + L+ E V+ ++ +
Sbjct: 97 NQLRQTADIMKVF-NDPVHGHIEIHPLLVRIIDTPQFQRLRYIKQLGGTYFVFPGASHNRFEHSLGVGYLAGCLVRELK---ERQPELDITQRDILCVEIAGLCHDLGHGPFSHMFDGRFIPLARQGLNWKHETASVEMFEHL---ITSNKLEEIMESYGLILEEDIAFIKEQIGGPIDETACEESWPYRGRPKEKSFLYEIVANKKNGIDVDKWDYFARDCHHLGIQNN---FDYRRLIKFTRVCEAGNQKHICARDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIEIMITEAFQKA----DCFFQ-IEGSKGKLYHISTAMEDMEAYTKLTDNIYLEILHSSRPELSEAREILHKIERRELYKFLGETQPEKVNEIPKDEYDGLAGDIANSKPEKDPPDVELTAEDFIVDVVNMDYGMKDQ---NPIDNVLFYCKADPSKAIKISKEQVSRLLPGTFSEQVIRVYCK 547
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q502K2|SAMH1_DANRE (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Danio rerio OX=7955 GN=samhd1 PE=2 SV=2) HSP 1 Score: 211.46 bits (537), Expect = 2.110e-59 Identity = 155/482 (32.16%), Postives = 246/482 (51.04%), Query Frame = 2
Query: 128 QLSQ-SEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAF--DNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEI-----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEI-----VHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSG--------IVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEI-KSK---------LKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETE 1462
+LSQ S +P F ND +HG I+L + ID+PQFQRLRHI+QLG Y V+ A ++RFEHSIG +LA L+K L ++ E+ I+ +D+ CV+IA LCHDLGHGP+SH ++ F + KHE SV++F L+E + E + + L ++ I IK I G + + ++ FL+E+VANK +G+DVDK+DY RD + G N D +R L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M +A + + R I + I E SK+ D+ I+ Y+SG I++ I R+LYK Q E N + +K +E+ +SK +DF + + + ++ + NP+ +V+FY K +P K ++ + L+ + E ++ ++ + +K E
Sbjct: 85 KLSQISTEPMKVF-NDPIHGHIELHPLLLHFIDTPQFQRLRHIKQLGGTYLVFPGASHNRFEHSIGVGYLAGCLVKAL---NERQPELFITKQDILCVQIAGLCHDLGHGPFSHMFDGMFIPKARPADKWKHEIASVQMFDHLVE-VNGLEAVMLHHGMRLPEDLI-FIKEQIAGPLESAVLDQSQWPYKGRPVEKSFLYEVVANKRNGIDVDKWDYFARDCYHLGIQNN---FDYQRFLRFARVCEVKGRKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITEAFLKADPHIQIQGSSGRIFTISSAIE----------DMEAYSKLTDHIFEQIL--YSSGPELSEARAILQNIICRRLYKCVGQTTSETNVDVSQEKLLDWAKELARSKPTGTEGNLIAEDFVVSVIHMDYGMKEK---NPINNVHFYCKNDPTKAIKIHKKQVSKLLPERFAEQLIRVYCKKTDDKSLE 542
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q6INN8|SAMH1_XENLA (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Xenopus laevis OX=8355 GN=samhd1 PE=1 SV=2) HSP 1 Score: 209.534 bits (532), Expect = 1.296e-58 Identity = 145/489 (29.65%), Postives = 242/489 (49.49%), Query Frame = 2
Query: 131 LSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR--KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKK------------------RMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDA-------------------LNEIVHNEDARNELIETVIGQKVY--DPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLR 1474
L Q+ ND +HG I+L + IID+P+FQRLR+I+QLG Y+V+ A ++RFEHSIG +LA L++ L ++ +++I D+ CV+IA LCHDLGHGP+SH ++ F + KHE SV +F L++ +E K ++ + L + + IK I G E +++ + FL+EIVANK +G+DVDK+DY RD + G N D KR L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M DA ++ V + A +L + + Q +Y DP + + E + KV H++ + + RI+ K +D++ +L + ++++ +DF + + + ++ + NP+ +V FY K +P K + + L+ K E ++ ++ + K E R
Sbjct: 104 LCQNSPSIMKVFNDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALH---ERQPDLQIDMRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPQKKFKHESASVAMFDHLIQSNGLEEAMK-ENGLCL-PDDLTFIKEQIAGPLSSEAEQQFNSSPNSSSWPYRGRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVGSKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFVKADPHIKIEGANGKYYSISGSVDDMVAYTKLTDNIYHQILYSNDPNLKEAREILQKVERRHLYKYIGQTHPHSNSRIEPDK----YDKLPADLASSVP----QTSAKDVELHAEDFIVDVIHMDYGMKEQ---NPINNVRFYCKADPRKAIKIRRDQVSQLLPEKFAEQIIRVYCKKTDEKSLETAKR 573
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q0VCA5|SAMH1_BOVIN (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Bos taurus OX=9913 GN=SAMHD1 PE=2 SV=1) HSP 1 Score: 207.608 bits (527), Expect = 3.675e-58 Identity = 146/429 (34.03%), Postives = 222/429 (51.75%), Query Frame = 2
Query: 164 VNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR---KHEDLSVEIFSMLLEH-IKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEI-----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDA-LNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSG------IVERIQERKLYKIFDQIQIELN----------PNFQGQKGHIDLQ-EIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQN 1348
+ND +HG I+ + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L+++L +++ E++IS+ D+ CV+IA LCHDLGHGP+SH ++ F P HE SV M+ EH I S+ Q + GL + I IK I G + I K++ FL+EIVANK +G+DVDK+DY RD + G N D KR L F R+ + +M H+ R++E+ +++D+F+ R+ LHR YQHK II+ M DA L H E I G+K + E +K+ D I+ I+++I+ R LYK + Q + PN D++ E + K +D + + + ++ + NP+ V FY K +
Sbjct: 106 INDPIHGHIEFHPLLMRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGRLVREL---SEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRF-IPLARPEIKWTHEQGSV----MMFEHLINSNGLQDVMKYYGLIPEEDILFIKEQITGPPESPIKDASKWLYKGRPKEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNS---FDYKRFLKFARVCEVDNMKHICTREKEVGNLYDMFHTRNCLHRRAYQHKVGNIIDTMITDAFLKADDHIE------ITGSAGRKYHISTAIDDMEAFTKLTDNIFLEILYSTDPNLNDARMILKKIESRNLYKFVGETQPMIQRIKKENYEHLPNEVASAKPSDVELEAELKAEDLIVDVINMDYGMEDK---NPIDHVRFYCKSD 514
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q9Y3Z3|SAMH1_HUMAN (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2) HSP 1 Score: 204.912 bits (520), Expect = 6.906e-57 Identity = 149/463 (32.18%), Postives = 237/463 (51.19%), Query Frame = 2
Query: 164 VNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRK--HEDLSVEIFSMLLEH-IKSDETQKIKDKIGL-KKNTIDLIKRIILGNFDKEID----------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIE-TVIGQKVYDPKIWFSS-EFISKVCDYHIWNIMS------KYTSGIVERIQERKLYKIFDQIQ-----------IELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNK 1453
+ND +HG I+L + IID+PQFQRLR+I+QLG GY+V+ A ++RFEHS+G +LA L+ L ++ E++IS+ DV CV+IA LCHDLGHGP+SH ++ F K HE SV M+ EH I S+ + + ++ GL + I IK I+G + ++ + + FL+EIV+NK +G+DVDK+DY RD + G N D KR + F R+ + + + RD+E+ +++D+F+ R+ LHR YQHK II+ M DA + ++ IE T G K Y E +K+ D I+ K I+++I+ R L+K + Q E P L ++K K +DF + + + +Q + NP+ V+FY K P + + + L+ K E ++ ++ + + K
Sbjct: 118 INDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHAL---GEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSV----MMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKA-------DDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEK---NPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRK 560
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A3Q1HNY4 (HD domain-containing protein OS=Anabas testudineus OX=64144 PE=4 SV=1) HSP 1 Score: 226.868 bits (577), Expect = 1.589e-63 Identity = 159/482 (32.99%), Postives = 246/482 (51.04%), Query Frame = 2
Query: 116 YMESQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRII-------LGNFDKEIDKKR----MFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSD-MWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIM------SKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANLCSNEI 1507
Y+ S LS S ND VHG ++ + +IID+PQFQRLR+I+QLG YFVY A ++RFEHS+G +LA EL + LK + D + E I ++D+ V+IA LCHDLGHGP+SH +E +KHE +S+E+F L+E + + + GL + IK +I GN K R FL+EIVANK +G+DVDKFDY RD + G N D +R L F R+ + D H+ +RD+E+++++D F+ R+ LHR YQH+ K IE M D L+++ +D + E E + + + D + +K+ D + I+ K I+ RI R LY + + + +K + ++ K +DF I+ V ++ ++ + NP+ +NFY K +P K +E + L+ E + ++ K R +T N C I
Sbjct: 43 YLMSALSIS-----AVFNDSVHGHMEFHPLLVKIIDTPQFQRLRYIKQLGGAYFVYPGASHNRFEHSLGVGYLAGELAQALKTKHDNEGENLIDEKDILSVQIAGLCHDLGHGPFSHMFE-----SVCPKKKHEQISIEMFDYLVE---ENGLKPLMQLYGLSDPDLSFIKEMIDPKPRDKDGNVSSWPHKGRGEDKSFLYEIVANKTNGVDVDKFDYFARDCHHLGMQNN---FDYRRFLKFARVCEAEDGKKHICIRDKEVYNMYDFFHTRYCLHRRAYQHRVNKAIEIMIKDVLSKV---KDIKIEGFEKTLLESIDDMAAY------TKLTDCLLQVILFSTDENLKEAKEILARICSRDLYVFLGETLVAESKTEWKKKL---AEPLRLKPEDFEIEQVTINYGMKEK---NPIEKMNFYNKSDPQKAVPLPKEQVSHLLPDTFSETFIRVYC----RKSLRRAEKTQLMNWCKENI 489
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A091HNY3 (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Fragment) OS=Calypte anna OX=9244 GN=N300_03336 PE=4 SV=1) HSP 1 Score: 226.098 bits (575), Expect = 2.281e-63 Identity = 157/452 (34.73%), Postives = 233/452 (51.55%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR---KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEID----------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMS------KYTSGIVERIQERKLYKIFDQIQIE----------LNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIF 1432
ND +HG I++ + IID+PQFQRLR+I+QLG YFV+ A ++RFEHSIG +LA L++ LK ++ E++I+ D+ CVEIA LCHDLGHGP+SH ++ F P KHE SVE+F L+ K +E K GL + +D IK I G + K++ FL++IVANK +G+DVDK DY RD + G N D R L F R+ + +D H+ RD+E +++D+F+ RH LHR YQHKT IIE M + E D + IE G++ + E +K+ D I+ K I+ +IQ R+LYK + Q E L + K D ++K K +DF + + + ++ + NP+ +V FY K +P K N E + + + E V+ ++
Sbjct: 3 NDPIHGHIEIHPLLVRIIDTPQFQRLRYIKQLGGTYFVFPGASHNRFEHSIGVGYLAGLLVRTLK---ERQPELDITQRDILCVEIAGLCHDLGHGPFSHMFDGRF-IPLARPGLKWKHETASVEMFEHLITSNKLEEAMK---SYGLVLEEDMDFIKEQIGGPIGESPSGKSWPYRGRQKEKSFLYDIVANKKNGIDVDKLDYFARDCHHLGIPNN---FDYNRYLKFTRVCEVNDEKHICTRDKEAGNLYDMFHERHWLHRRAYQHKTGNIIELMQVSWITEAFQKADKFFK-IEGSGGKQYHISTAMEDMEAYAKLTDNIYLEILHSNRPELKEAQEILHKIQRRELYKYLGETQPEGSKGILKSNNLGESIANAKPEKDPPKVKPKAEDFIVDVINIDYGMKEQ---NPIDNVLFYCKADPSKAVNICREQVSKFLPITFSEQVIRVY 440
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A091GUW7 (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Fragment) OS=Buceros rhinoceros silvestris OX=175836 GN=N320_12103 PE=4 SV=1) HSP 1 Score: 225.713 bits (574), Expect = 5.992e-63 Identity = 158/472 (33.47%), Postives = 245/472 (51.91%), Query Frame = 2
Query: 125 SQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR---KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEI----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETV--IGQKVYDPKIWFSS-EFISKVCDYHIWNIMS------KYTSGIVERIQERKLYKIFDQIQIELNPN----------FQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTET 1441
S L Q + ND VHG I++ + IID+PQFQRLR+I+QLG YFV+ A ++RFEHSIG +LA L++ LK ++ E++I+ D+ CVEIA LCHDLGHGP+SH ++ F P KHE SV++F L I S++ +++ GL + +D IK I G D+ K++ FL+EIVANK +G+DVDK+DY RD + G N D KR+L F+R+ + + H+ RD+E +++D+F+ R+ LHR YQHKT IIE M L + + + + G K+Y E +K+ D I+ K I+ +I+ R+LYK + + E N F K D +++ K +DF I + + ++ +N P+ +V FY K +P K +E + L+ + E V+ ++ ++
Sbjct: 13 SALRQQDVDIMKVFNDPVHGHIEIHPLLVRIIDTPQFQRLRYIKQLGGTYFVFPGASHNRFEHSIGVGYLAGCLVRALK---ERQPELDITQRDILCVEIAGLCHDLGHGPFSHMFDGRF-IPVARPDLKWKHETASVKMFEHL---IASNKLEEVMTSYGLVLEEDLDFIKEQIGGPVDETACEESWPYRGRQKEKSFLYEIVANKTNGIDVDKWDYFARDCHHLGIQNN---FDYKRLLKFIRVCEAENQKHICARDKEAGNLYDMFHTRNWLHRRAYQHKTGNIIEIMQVLLLPFLAFQAFQKADKFFEIEGSGGKLYQISTALEDMEAYTKLTDNIYLEILHSSRPELKEAREILRKIERRELYKFLGETRPETGRNIVKNNSLAESFANSKPEKDPPDVELKAEDFIIDVINMDYGMKEQN---PIDNVLFYCKADPSKAVRIRKEQVSKLLPMTFAEQVIRVYCKS 471
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A093BJD6 (SAM domain and HD domain-containing protein 1 (Fragment) OS=Chaetura pelagica OX=8897 GN=M959_02996 PE=4 SV=1) HSP 1 Score: 225.713 bits (574), Expect = 6.698e-63 Identity = 153/455 (33.63%), Postives = 237/455 (52.09%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR---KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEI----------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMS------KYTSGIVERIQERKLYKIFDQIQIE----------LNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTET 1441
ND +HG I++ + IID+PQFQRLR+I+QLG YFV+ A ++RFEHSIG +LA L++ LK ++ E++I+ D+ CVEIA LCHDLGHGP+SH ++ F P KHE SVE+F L + S++ +++ GL + + IK I G D+ K++ FL++IVANK +G+DVDK DY RD + G N D R L F R+ + + H+ RD+E +++D+F+ RH LHR YQHKT IIE M + E D + IE G++ + E +K+ D I+ K I+ +I+ R+LYK + Q E L + K D +++ K +DF + + + ++ + NP+ V+FYTK +P K N E + + + E V+ ++ ++
Sbjct: 27 NDPIHGHIEIHPLLVRIIDTPQFQRLRYIKQLGGTYFVFPGASHNRFEHSIGVGYLAGLLVRTLK---ERQPELDITQRDILCVEIAGLCHDLGHGPFSHMFDGRF-IPLARPGLKWKHETASVEMFEHL---VTSNKLEEVMRSYGLVLEEDFNFIKEQIGGPIDEAACEKSWPYRGRPKEKSFLYDIVANKKNGIDVDKLDYFARDCHHLGIPNN---FDYNRYLKFTRVCEVNSQKHICTRDKEAGNLYDMFHERHWLHRRAYQHKTGNIIEIMQVLEITEAFQKADKFFK-IEGSGGKQYHISTAMEDMEAYTKLTDNIYLEILHSNRPELKEAREILHKIERRELYKYLGETQPETMEGIGKSNNLGEDIANSKPEKDPPDVEVKAEDFIVDVINIDYGMKEQ---NPIDKVHFYTKADPSKAVNIRREQVSKFLPVTFSEQVIRVYYKS 467
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A3Q1HLT1 (HD domain-containing protein OS=Anabas testudineus OX=64144 PE=4 SV=1) HSP 1 Score: 223.787 bits (569), Expect = 1.547e-62 Identity = 158/460 (34.35%), Postives = 242/460 (52.61%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKD----KIGLKKNTIDLIKRIILGNFDKE-IDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSD-MWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIM------SKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQ-SENRG----NPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFT-ETIPNKETERMLRTLKANL 1492
ND VHG ++ + +IID+PQFQRLR+I+QLG YFVY A ++RFEHS+G +LA EL + LK + D + E I ++D+ V+IA LCHDLGHGP+SH +E F +HE +S+E+F L+E + K+ D + K IDL R G E + + FL+EIV+NK +G+DVDKFDY RD + G N D +R L F R+ + D H+ +RD+E+++++D F+ R+ LHR YQH+ K IE M D L+++ +D + E E + + + D + +K+ D + I+ K I+ RI R LY + IE + ++ K +DF I+ V S LQ + N G NP+ +NFY K +P K +E + L+ E + ++ +T+ E +R+ K N+
Sbjct: 45 NDSVHGHMEFHPLLVKIIDTPQFQRLRYIKQLGGAYFVYPGASHNRFEHSLGVGYLAGELAQALKTKHDNEGENLIDEKDILSVQIAGLCHDLGHGPFSHMFESVFS-----VLQHEQISIEMFEHLVEENRLKPLMKLYDLSDRDLHFIKEMIDLEPRGKDGKLRFEGRGEDKSFLYEIVSNKTNGVDVDKFDYFARDCHHLGMQNN---FDYRRFLKFARVCEAEDGKKHICIRDKEVYNMYDFFHTRYCLHRRAYQHRVNKAIEIMIKDVLSKV---KDIKIEGFEKTLLESIDDMAAY------TKLTDSLLQVILFSTDENLKEAKEILARICSRDLYVFLGETLIEWKKKLA--------EPLRLKPEDFEIE-VGSYLHLQVTINYGMKERNPIEKMNFYNKSDPQKAVPLPKEQVSHLLPDTFSETFIRVYCKKTLQPDERKRLENWCKENI 478
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000057570.1 (deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [Source:NCBI gene;Acc:111191578]) HSP 1 Score: 209.92 bits (533), Expect = 6.245e-60 Identity = 158/507 (31.16%), Postives = 260/507 (51.28%), Query Frame = 2
Query: 140 SEDPETTFV----NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDN-----ETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEID-------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRI-AKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL----------------NEIVHNEDARNELIETVIG--QKVYDPKIWFSSEFISKVCDYHIWN-----------IMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDL---QEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANLCSNEIEG 1513
++ P +T V ND VHG I++ + +IID+P+FQRLR+++Q G GY+VY A ++RFEHS+G HLA +L++ LK D ++ I DED CV+IA LCHDLGHGP+S HAFD+ + + KHED SV++F L+ IK ++ K LK + IK +I + D + + +++ FL+EIVANK +G+DVDK DY RD + G ++ N H+ R + F R+ ++ H+ MRD+E +++++F+ R+L+ + H+ K +E M DAL E V++ D L + ++ ++ D + S E I ++ D ++ + S T+ + + E+ + KI +Q Q L+ Q K +D Q K +DF I + ++ ++ NP+ S+ FY K P K + + ++ E +M+F + +P K +R+ L S E G
Sbjct: 2 ADQPTSTQVYKVFNDSVHGHIEMHPLLVKIIDTPEFQRLRNVKQFGGGYYVYPGASHNRFEHSLGVAHLAGKLVQNLK---DSQPDLGIDDEDELCVQIAGLCHDLGHGPFS----HAFDDFMEQVQEDDKWKHEDQSVKMFDHLI--IKGHIKGIMEKKYNLKNEDFEFIKELINPDKDNKTEWQFKGRTQEKSFLYEIVANKLTGIDVDKMDYFSRDCHHLGMTS-NFSHE--RYMMFARVCTDENGEKHICMRDKEAVNMYELFHVRNLIRQRACHHRVAKAVELMITDALIEANSHFKLGEENLTICEAVNDLDTFTHLTDDILQEIERSTDDNLKQSQEIIKRIRDRDLYRFVDGELFKRNEVRSLKTTKEKKDLLEKWIKKITNQ-QTNLSSEEQQLKDFLDKKNNQHPKLSPEDFRIVVIDLTYGME---ESNPIDSLLFYKKNQPDKSYKLSKAKVSHMLPGTFAETRVMLFYKGLPKKHVKRLWEKLMPLEVSGEPTG 492
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000032130.1 (deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [Source:NCBI gene;Acc:103028826]) HSP 1 Score: 207.608 bits (527), Expect = 1.762e-58 Identity = 155/465 (33.33%), Postives = 245/465 (52.69%), Query Frame = 2
Query: 122 ESQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEH--IKSDETQKIKDKIGLKKNTIDLIKRIILGNFD-------KEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPK--IWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQK-GHIDL-QEIKSKLKDF--PIKFVISSFALQSE---------NRG----NPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIF 1432
E ++ E ND VHG I++ + +IID+P+FQRLR+I+QLG GY+VY A ++RFEHS+G HLA +L++ LK + +EI+ D CV+IAALCHDLGHGP+SH ++ F + KHED SV++F L+E IK ++ KD + I +I G K DKK+ FL++IVAN +G+DVDK DY RD + G N H+ R + F R+ ++ + MRD+E +++++F+ R+LLH YQH+ VK +E M DAL E A++ L + + DPK ++ + + + K+ + + + I++R+ +R LYK+ F+ Q+ H+D +E K L+ + I+ + + L E N G NP+ S+ FY K +P ++ + L+ K E +M+F
Sbjct: 12 EQSTTKKEKAIYKVFNDSVHGHIEMHPLLVKIIDTPEFQRLRNIKQLGGGYYVYPGASHNRFEHSLGVAHLAGKLLQSLKKTLPEG--LEITPNDELCVQIAALCHDLGHGPFSHAFD-IFMKKLDSSWKHEDASVKMFKHLIEENGIKEIMARENKDWDAFSEKDFMFIMELIQGPSKSASEWPYKGRDKKKAFLYDIVANHRNGIDVDKMDYFTRDCHHLGMKC-NFSHE--RFITFARVCDENGETQICMRDKEAMNMYELFHVRNLLHHNAYQHRVVKAVELMIMDALKE------AKDHL---NLKEATMDPKTFVYLTDDILQKILNKPEKKL--EKAQKIIKRVLKRDLYKLLGV------KTFEPQELKHLDSDEEWKKVLETWLENIQTPVGARKLNPEDFTEVQVKFNYGMKDKNPIDSLRFYRKYDPNTPIKLSKDEVSHLLPEKFAETKVMLF 453
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000045292.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000081.1:2518931:2530795:1 gene:ENSAMXG00000031001.1 transcript:ENSAMXT00000045292.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 199.134 bits (505), Expect = 6.930e-57 Identity = 147/476 (30.88%), Postives = 237/476 (49.79%), Query Frame = 2
Query: 170 DIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR-KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEI-------------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMW-HLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFS-SEFI-SKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQE------------IKSKLKDFPIKFVISSFALQ------SENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANL 1492
D VHG I L + IID+PQFQRLR+I+QLG GYFV+ A ++RFEHSIG HLA +L++ L+ D E+ I+D D CV+IA LCHDLGHGP+SH +E E E KHE++SV +F L+E ++ ++ ++++ I+ +I +++ +L++IV N+ +G+DVDK DY RD + G N H+ R L F R+ ++ + +RD+E +++++F+ R LH Y H+ K +E M DAL A NE + I V DP + ++FI K+ D + + GI+ERI +R++YK D N H+DL E +++K ++F F + N +P+ + FY + P + + L+ + EI +M+F + +E ER++ +K ++
Sbjct: 14 DPVHGHIALDPLLVSIIDTPQFQRLRNIKQLGGGYFVFPGASHNRFEHSIGVAHLAGKLVQSLRT----DNELNITDTDELCVKIAGLCHDLGHGPFSHVFEGFMKEENPESNWKHEEMSVRMFDYLIE--ENGISEIMRNEYNFTDQDFQFIRELIYTPKPPNNPNPENRQWSYTGRPQEKSYLYQIVNNQTTGIDVDKMDYFSRDCHHLGIKC-NFSHE--RYLVFARVCIDEELGTQICIRDKEAMNMYELFHIRSYLHHNIYHHRVTKAVESMIVDALR-------AANERLS--ISAAVNDPSAYMKLTDFILQKILD--LADPEHPAAPGIIERISKREVYKFIDGKVFRPN-----DVRHVDLAESWEEKLQAWVEHVRNKAGGHQLEFNAQDFKIMPIKINCGRNEDDPISFLRFYRRDEPNIPIQLSRDEISFLLPERFAEIKVMVFYK----REDERVVDLMKRHI 460
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000040847.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000081.1:2469780:2530795:1 gene:ENSAMXG00000031001.1 transcript:ENSAMXT00000040847.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 199.134 bits (505), Expect = 6.930e-57 Identity = 147/476 (30.88%), Postives = 237/476 (49.79%), Query Frame = 2
Query: 170 DIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR-KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEI-------------DKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMW-HLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFS-SEFI-SKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQE------------IKSKLKDFPIKFVISSFALQ------SENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANL 1492
D VHG I L + IID+PQFQRLR+I+QLG GYFV+ A ++RFEHSIG HLA +L++ L+ D E+ I+D D CV+IA LCHDLGHGP+SH +E E E KHE++SV +F L+E ++ ++ ++++ I+ +I +++ +L++IV N+ +G+DVDK DY RD + G N H+ R L F R+ ++ + +RD+E +++++F+ R LH Y H+ K +E M DAL A NE + I V DP + ++FI K+ D + + GI+ERI +R++YK D N H+DL E +++K ++F F + N +P+ + FY + P + + L+ + EI +M+F + +E ER++ +K ++
Sbjct: 14 DPVHGHIALDPLLVSIIDTPQFQRLRNIKQLGGGYFVFPGASHNRFEHSIGVAHLAGKLVQSLRT----DNELNITDTDELCVKIAGLCHDLGHGPFSHVFEGFMKEENPESNWKHEEMSVRMFDYLIE--ENGISEIMRNEYNFTDQDFQFIRELIYTPKPPNNPNPENRQWSYTGRPQEKSYLYQIVNNQTTGIDVDKMDYFSRDCHHLGIKC-NFSHE--RYLVFARVCIDEELGTQICIRDKEAMNMYELFHIRSYLHHNIYHHRVTKAVESMIVDALR-------AANERLS--ISAAVNDPSAYMKLTDFILQKILD--LADPEHPAAPGIIERISKREVYKFIDGKVFRPN-----DVRHVDLAESWEEKLQAWVEHVRNKAGGHQLEFNAQDFKIMPIKINCGRNEDDPISFLRFYRRDEPNIPIQLSRDEISFLLPERFAEIKVMVFYK----REDERVVDLMKRHI 460
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000041115.1 (deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [Source:NCBI gene;Acc:111197473]) HSP 1 Score: 194.897 bits (494), Expect = 2.602e-56 Identity = 116/288 (40.28%), Postives = 176/288 (61.11%), Query Frame = 2
Query: 140 SEDPETTFV----NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEH--IKSDETQKIKDKIGLKKNTIDLIKRIILGNFDK---EIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNE 976
++ P +T V ND VHG I++ + +IID+P+FQR R+I+QLG Y+VY A ++RFEHS+G HLA +L++ LK + +EI+ D CV+IAALCHDLGHGP+SH ++ F + KHED S+E+F L++ IK ++ KD + IK++I G + E +KK+ FL++IVAN +G+DVDK DY RD + G N H+ R + F R+ +++ + MRD+E +++++F+ R+LLH QH+ VK +E M DAL E
Sbjct: 2 ADQPTSTQVYKVFNDSVHGHIEMHPLLVKIIDTPEFQRSRNIKQLGGVYYVYPGASHNRFEHSLGVAHLAGKLLQSLKKNLPEG--LEITPNDELCVQIAALCHDLGHGPFSHAFD-IFMKDFDSKWKHEDASIEMFDHLIQKNGIKKIMEEENKDWDAFSEEHFMFIKKLIRGTKTEQPNEEEKKKAFLYDIVANYRNGIDVDKMDYFTRDCHHLGMKC-NFSHE--RFITFARVCEENGETQICMRDKEAMNMYEIFHVRNLLHHNACQHRVVKAVELMIMDALKE 283
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008964.1 (pep scaffold:Pmarinus_7.0:GL476766:34701:72987:-1 gene:ENSPMAG00000008111.1 transcript:ENSPMAT00000008964.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 184.496 bits (467), Expect = 1.272e-53 Identity = 115/286 (40.21%), Postives = 170/286 (59.44%), Query Frame = 2
Query: 161 FVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGN----------FDKEIDKK---RMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNE 976
+ND +HG+I+L + I+D+P+FQRLR I+QLG + VY SA ++RFEH IGT HLA +L++ LK + KE I+D DV CVEIA LCHDLGHGP+SH +E + IE KHE SVE+ L+E + QK + GL+ + + LI +I+ F +I+K+ +MFLFEIVAN + +DVDKFDY RD+ Y G+ N + +R + R+ + +H+ ++ ++ ++F+ R LHR YQH+ K+IE +A+ E
Sbjct: 2 MINDPIHGLIELKKPLLLIVDTPEFQRLRFIKQLGLCHKVYPSAVHTRFEHCIGTSHLAGQLVRHLK---ECSKEHNITDMDVLCVEIAGLCHDLGHGPFSHAFETVMKKKGIE-WKHELKSVEMLCHLIE---KNSLQKDLENCGLQFPHHLILIASLIVAGPLSSATCKIYFWYKIEKEYKCKMFLFEIVANDLNCIDVDKFDYFARDAYYLGF---NTGFEHQRYIQNARVCEFHGDFHICQPKKQWSNLLELFHVRERLHRNAYQHRVTKLIEHKVAEAIKE 277
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Match: samhd1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:553453]) HSP 1 Score: 186.808 bits (473), Expect = 5.884e-53 Identity = 137/446 (30.72%), Postives = 228/446 (51.12%), Query Frame = 2
Query: 131 LSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR---KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEIDKK---------RMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWH---LAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL---NEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMS------KYTSGIVERIQERKLYKIFDQIQ------------IELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLK 1357
+ Q ND +HG I + + IID+PQFQRLR+I+QLG Y+V+ A ++RFEHS+G +LA +L +++ + E+ I++ DV CV+IA LCHDLGHGP+SH ++++F P KHE SV++F L++ +E + + GLK +D IK I G D K + FL+EIVANK +G+DVDK+DY RD + G N D +R + F+R+ + + + R++E+ +++D+F+ R+ LHR YQH+ IIE M +A ++ + E + ++ I + D + +K+ D + I+ K I+E + R+LYK + Q ++L + + L +K +DF + + + ++ + NP+ +V FY K++P K
Sbjct: 50 MCQDSKQNMKVFNDPIHGHIVMHPLLVRIIDTPQFQRLRNIKQLGGTYWVFPGASHNRFEHSMGVGYLAGQLATAIQS---RQPELGINERDVLCVQIAGLCHDLGHGPFSHMFDNSFI-PAARPGCKWKHEVASVQMFDHLVQANGLEEV--LSKEYGLKLPEDLDFIKEQIAGPLADIADSKWPYKGRTKDKGFLYEIVANKSNGIDVDKWDYFARDCHHLGIQNN---FDHRRFIEFVRVCEVENERTKKVICFRNKEVGNLYDMFHTRNCLHRRAYQHRVGNIIELMIKEAFLKADKYIKIEGSGGKMFS--ISGAIDDMVAY------TKLTDLIFYEILHSRDPNLKEARVILENVVCRRLYKFVNHTQPGEATLPKEPDEVKLAKEIANSEPEMPLN-VKLNPEDFVVHVINLDYGMKEK---NPINNVWFYCKEDPDK 474
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008965.1 (pep scaffold:Pmarinus_7.0:GL476766:34734:72987:-1 gene:ENSPMAG00000008111.1 transcript:ENSPMAT00000008965.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 182.57 bits (462), Expect = 6.641e-53 Identity = 112/276 (40.58%), Postives = 163/276 (59.06%), Query Frame = 2
Query: 161 FVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIIL----GNFDKEID--------KKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIE 949
+ND +HG+I+L + I+D+P+FQRLR I+QLG + VY SA ++RFEH IGT HLA +L++ LK + KE I+D DV CVEIA LCHDLGHGP+SH +E + IE KHE SVE+ L+E + QK + GL+ + + LI +I+ G + K +MFLFEIVAN + +DVDKFDY RD+ Y G+ N + +R + R+ + +H+ ++ ++ ++F+ R LHR YQH+ K+IE
Sbjct: 2 MINDPIHGLIELKKPLLLIVDTPEFQRLRFIKQLGLCHKVYPSAVHTRFEHCIGTSHLAGQLVRHLK---ECSKEHNITDMDVLCVEIAGLCHDLGHGPFSHAFETVMKKKGIE-WKHELKSVEMLCHLIE---KNSLQKDLENCGLQFPHHLILIASLIVAPKAGPLSSATEWLYIEKEYKCKMFLFEIVANDLNCIDVDKFDYFARDAYYLGF---NTGFEHQRYIQNARVCEFHGDFHICQPKKQWSNLLELFHVRERLHRNAYQHRVTKLIE 267
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008967.1 (pep scaffold:Pmarinus_7.0:GL476766:55761:72987:-1 gene:ENSPMAG00000008111.1 transcript:ENSPMAT00000008967.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 160.614 bits (405), Expect = 1.562e-46 Identity = 94/195 (48.21%), Postives = 124/195 (63.59%), Query Frame = 2
Query: 161 FVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCR 745
+ND +HG+I+L + I+D+P+FQRLR I+QLG + VY SA ++RFEH IGT HLA +L++ LK + KE I+D DV CVEIA LCHDLGHGP+SH +E + IE KHE SVE+ L+E + Q KD LK T L+ + L ++ K +MFLFEIVAN + +DVDKFDY R
Sbjct: 2 MINDPIHGLIELKKPLLLIVDTPEFQRLRFIKQLGLCHKVYPSAVHTRFEHCIGTSHLAGQLVRHLK---ECSKEHNITDMDVLCVEIAGLCHDLGHGPFSHAFETVMKKKGIE-WKHELKSVEMLCHLIE---KNSLQ--KDLENLKTITFLLLSKTTLTEIIEKEYKCKMFLFEIVANDLNCIDVDKFDYFAR 187
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Nematostella
Match: EDO35454 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLH4]) HSP 1 Score: 194.512 bits (493), Expect = 1.454e-55 Identity = 120/313 (38.34%), Postives = 175/313 (55.91%), Query Frame = 2
Query: 77 LRYTTDFRIT*ANYMESQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR---KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKK------------RMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL 970
+R+ T F + + +S L+ S T ND +HG I + +IID+PQFQRLR+++QLG YFV+ A ++RFEHSIGT HLA L+K ++ + + I+D DV CV+IA LCHDLGHGP+SH ++ F P KHE SV++F+ L++ K E + + GL ++ I+ +I G + E K + +L+EIVANK +G+DVDK+DY RD G N D KR + R+ K + +RD+E +I+D+F+ R L + YQHKT IIE M +A
Sbjct: 45 IRFVTWFSLM-ISMSDSALTPSLQILTMLFNDPIHGHIDVHPLCVKIIDTPQFQRLRNLKQLGGCYFVFPGAAHNRFEHSIGTSHLAGGLLKSIRKRQ---PGLGITDVDVLCVKIAGLCHDLGHGPFSHMFDAGF-IPAARPGCDWKHEQASVDMFNYLVDDNKLLEEFR---RYGLSDKDMEFIQELIAGPRNMETPLKTQDWPYTGRSIEKSYLYEIVANKRTGIDVDKWDYFARDCHNLGIRNS---FDHKRFMKLARVIKVGKRQQICIRDKEAGNIYDMFHTRTSLFKRAYQHKTANIIETMITEAF 346
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Nematostella
Match: EDO35455 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLH5]) HSP 1 Score: 194.512 bits (493), Expect = 1.729e-54 Identity = 118/297 (39.73%), Postives = 169/297 (56.90%), Query Frame = 2
Query: 125 SQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR---KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKK------------RMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL 970
SQ S + F ND +HG I + +IID+PQFQRLR+++QLG YFV+ A ++RFEHSIGT HLA EL++ ++ +Q E+ I+ DV CV+IA LCHDLGHGP+SH ++ F P KHE SV++F+ L++ K E + + GL ++ I+ +I G + E K + +L+EIVANK +G+DVDK+DY RD G N D KR + R+ K + +RD+E +I+D+F+ R L + YQHKT IIE M +A
Sbjct: 112 SQASNAVSSLKVF-NDPIHGHIDVHPLCVKIIDTPQFQRLRNLKQLGGCYFVFPGAAHNRFEHSIGTSHLAGELLESIR---EQQPELGITYVDVLCVKIAGLCHDLGHGPFSHMFDAGF-IPAARPGCDWKHEQASVDMFNYLVDDNKLSEEFR---RYGLSDKDMEFIQELIAGPRNMETPLKTQDWPYTGRSVEKSYLYEIVANKRTGIDVDKWDYFARDCHNLGIRNS---FDHKRFMKLARVIKVGKRQQICIRDKEAGNIYDMFHTRTSLFKRAYQHKTANIIETMITEAF 397
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Nematostella
Match: EDO26257 (pep supercontig:ASM20922v1:NEMVEscaffold_7765:3208:3433:-1 gene:NEMVEDRAFT_v1g154803 transcript:EDO26257 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 62.3882 bits (150), Expect = 1.001e-12 Identity = 29/52 (55.77%), Postives = 39/52 (75.00%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIG 322
ND +HG I + +IID+PQFQRLR+++QLG YFV+ A ++RFEHSIG
Sbjct: 4 NDPIHGHIDVHPLCVKIIDTPQFQRLRNLKQLGGCYFVFPGAAHNRFEHSIG 55
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Medaka
Match: samhd1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:NCBI gene;Acc:101159989]) HSP 1 Score: 211.846 bits (538), Expect = 9.964e-61 Identity = 147/467 (31.48%), Postives = 236/467 (50.54%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR---KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEIDKKRM----------FLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEI-----VHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTS------GIVERIQERKLYKIFDQIQI----------ELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETE 1462
ND +HG ++L + +IID+PQFQRLR+I+QLG YFV+ A ++RFEHSIG +LA +L++ L ++ E+ I D+ CV+IA LCHDLGHGP+SH ++ F + P+ KHE S+++F L+E S+ + + ++ GL +D IK I G + ++ FL+EIVANK +G+DVDK+DY RD + G N D +R L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M +A + + + + + T I V +K+ DY I++ +S I+ I R+LYK Q Q E P Q + LQ +DF + ++ + ++ + NP+ +V FY K +P K + + L+ E ++ ++ + N+ E
Sbjct: 82 NDPIHGHVELHPLLIKIIDTPQFQRLRNIKQLGGTYFVFPGASHNRFEHSIGVGYLAGQLVQAL---NERQPELLICHRDILCVQIAGLCHDLGHGPFSHMFDGMFIPKAC-PQVNWKHETASLDMFDHLVE---SNGLKVVMEEHGLVLPEDLDFIKEQIAGPLSTQTPGQKWPYKGRPEDKSFLYEIVANKRNGIDVDKWDYFARDCYHLGIQNN---FDYQRFLKFARVCEVDGQKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVCNIIETMITEAFLKADPYIQIEGTEGKMFTLSTAIDDMVA----------YTKLTDYVFEQILNSSSSELREAREILHNIVCRRLYKCLGQTQPDQTIWEQELSESTP--QNSSSAVSLQP-----QDFIVNVIVMDYGMKEK---NPINNVRFYCKNDPNKAIQIRKNQVSKLLPEHFAEQLIRVYFKKTDNESLE 518
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Medaka
Match: samhd1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:NCBI gene;Acc:101159989]) HSP 1 Score: 211.075 bits (536), Expect = 4.194e-60 Identity = 145/469 (30.92%), Postives = 237/469 (50.53%), Query Frame = 2
Query: 167 NDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPR---KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLK-KNTIDLIKRIILGNFDKEIDKKRM----------FLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEI-----VHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTS------GIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKS------------KLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETE 1462
ND +HG ++L + +IID+PQFQRLR+I+QLG YFV+ A ++RFEHSIG +LA +L++ L ++ E+ I D+ CV+IA LCHDLGHGP+SH ++ F + P+ KHE S+++F L+E S+ + + ++ GL +D IK I G + ++ FL+EIVANK +G+DVDK+DY RD + G N D +R L F R+ + H+ RD+E+ +++D+F+ R+ LHR YQHK IIE M +A + + + + + T I V +K+ DY I++ +S I+ I R+LYK Q Q + + I QE+ + +DF + ++ + ++ + NP+ +V FY K +P K + + L+ E ++ ++ + N+ E
Sbjct: 111 NDPIHGHVELHPLLIKIIDTPQFQRLRNIKQLGGTYFVFPGASHNRFEHSIGVGYLAGQLVQAL---NERQPELLICHRDILCVQIAGLCHDLGHGPFSHMFDGMFIPKAC-PQVNWKHETASLDMFDHLVE---SNGLKVVMEEHGLVLPEDLDFIKEQIAGPLSTQTPGQKWPYKGRPEDKSFLYEIVANKRNGIDVDKWDYFARDCYHLGIQNN---FDYQRFLKFARVCEVDGQKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVCNIIETMITEAFLKADPYIQIEGTEGKMFTLSTAIDDMVA----------YTKLTDYVFEQILNSSSSELREAREILHNIVCRRLYKCLGQTQPDQTVTVSQETIKIWEQELSESTPQNSSSAVSLQPQDFIVNVIVMDYGMKEK---NPINNVRFYCKNDPNKAIQIRKNQVSKLLPEHFAEQLIRVYFKKTDNESLE 556
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Medaka
Match: ENSORLT00000044675.1 (deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [Source:NCBI gene;Acc:101162528]) HSP 1 Score: 95.1301 bits (235), Expect = 1.174e-20 Identity = 83/252 (32.94%), Postives = 122/252 (48.41%), Query Frame = 2
Query: 509 KHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGN-FDKEIDKK--------------RMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRI----AKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDAL---NEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTS------GIVERIQERKLYKIFDQIQ 1180
+HED SVE+F LLE + T+ + L+ N + IK +ILG K+ DK + FL+EIV+NK +G+DVDKFDY RD + G N D R F R+ K H+ RD+E +++D+FY R LHR YQHK K +E M DAL N+ + + E E + D K + E +++ D I+ +S I+ERI+ R LY++ D+ +
Sbjct: 30 RHEDASVEMFQYLLEKNRELLTEMKNSR--LEDNDLVFIKELILGEPLKKKSDKPEDPSDWPYEGRGEDKSFLYEIVSNKQNGIDVDKFDYFARDCHHLGLKNN---FDHMRYFKFTRVIGVEKNKLKRKHICSRDKEAGNLYDLFYTRDRLHRRAYQHKVTKNVEIMIKDALLKANKHIKFKGKDKEKKENFFT--ISDAKD--NMEAYTQLTDQVTQRILESSSSELEQARNILERIKTRDLYELVDEAK 272
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079667.1 (SMESG000079667.1) HSP 1 Score: 976.467 bits (2523), Expect = 0.000e+0 Identity = 475/477 (99.58%), Postives = 476/477 (99.79%), Query Frame = 2
Query: 119 MESQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANLCSNEIEGLREKYIFRAKLY 1549
MESQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALN+IVHNEDARNELIETVIG KVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANLCSNEIEGLREKYIFRAKLY
Sbjct: 1 MESQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDMWHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNDIVHNEDARNELIETVIGPKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANLCSNEIEGLREKYIFRAKLY 477
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079583.1 (SMESG000079583.1) HSP 1 Score: 739.569 bits (1908), Expect = 0.000e+0 Identity = 357/475 (75.16%), Postives = 412/475 (86.74%), Query Frame = 2
Query: 131 LSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDM--WHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANLCSNEIEGLREKYIFRAKLY 1549
++++ + +FVNDIVHGIIKLP YIKEIID+PQFQRLRHIRQLGFGY VY +AGYSRFEHSIGTFHLASELIKQLK+Q +++K ISD++VKCVEIAALCHDLGHGP+SH WEHAFD++TI+PRKHEDLSVE+F LL H K+ E + IK+KI L I+ I+++ILG ++K D+++MF FEIVANK SGLDVDKFDYLCRDSIY GWSNKNKIHDIKRILH LRIAKKSD WHLAMRDREIFHIHDVFYYRHLLHRY YQHKTVK+IECMF ALN+IVHNEDARNELIETVIG KVYDPKIWFSS+FISKVCDYHIWNIMSKYTSGIVE+IQERKLYKIFDQIQI+L+PNFQGQ GHIDLQEIKSKLKDF IK V SSF++ SEN+GNPLLSVNFY+K+NP +C NY +++LPDLVKL +E VL I TET P++ET++ L+TL NL + +I LREKY F+ LY
Sbjct: 1 MTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEMFLRLLYHKKTGEIKNIKEKIKLNTEMINFIEKLILGTYNK--DEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVHNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPNFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTILTETKPDEETKKQLKTLMDNLINRKIASLREKYTFKRMLY 473
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079585.1 (SMESG000079585.1) HSP 1 Score: 668.692 bits (1724), Expect = 0.000e+0 Identity = 325/432 (75.23%), Postives = 372/432 (86.11%), Query Frame = 2
Query: 260 LGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDM--WHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANLCSNEIEGLREKYIFRAKLY 1549
+GFGY VY +AGYSRFEHSIGTFHLASELIKQLK+Q +++K ISD++VKCVEIAALCHDLGHGP+SH WEHAFD++TI RKHEDLSVE+F LL H K+ E + IK+KI L I+ I+++ILG ++K D+++MF FEIVANK SGLDVDKFDYLCRDSIY GWSNKNKIHDIKRILH LRIAKKSD WHLAMRDREIFHIHDVFYYRHLLHRY YQHKTVK+IECMF ALN+IVHNEDARNELIETVIG KVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVE+IQERKLYKIFDQIQI+L+PNFQGQ GHIDLQEIKSKLKDF IK V SSF++ SEN+GNPLLSVNFY+K+NP +C NY +++LPDLVKL +E VL I TET PN+ET++ L+TL +L + +I LREKY F+ LY
Sbjct: 1 MGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIPSRKHEDLSVEMFLRLLYHKKTGEIKNIKEKIKLNTEMINFIEKLILGTYNK--DEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVHNEDARNELIETVIGPKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPNFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTILTETKPNEETKKQLKTLMDDLINRKIASLREKYTFKRMLY 430
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079633.1 (SMESG000079633.1) HSP 1 Score: 474.167 bits (1219), Expect = 2.547e-163 Identity = 245/473 (51.80%), Postives = 334/473 (70.61%), Query Frame = 2
Query: 164 VNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNE-TIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDM--WHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKV-YDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIF--DQIQIELNPNFQGQKGHI-DLQEIKSKLKDFP-IKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERML---RTLKANLCSNE----IEGLREKYIFR 1537
+NDIVHG I LP Y+K IID+ +FQRLR+I Q+G +Y SA SRFEHS+GTF+LAS+LIKQLK+Q + + ++ I+ E+VKCVE+AALCHDLGHGP+SHFWEHAFD I+ RKHED+SVEIF L++ KS T+ IK IGL + ID I R+I G +++E D ++ FLF+IVANK SGLDVDK DYLCRDS Y GWSN NKIHD KR+++F R+ K WHLAMRDRE+F +++VF +RH+LHRYG QH+ VK IECMF + + +++ N AR+E +ETV+ QKV Y+ IWFS +FISKV DYH+W+++ KY + + IQER LYK+ QIQI NF I DLQ + I +S ++LQ+EN+G+PL+ + FY+K+NP K NY+++SLP+ + LK DEI+LM+F E E E +L R+L++ +++ + L+ KY+F+
Sbjct: 2 INDIVHGTITLPEYVKVIIDTEEFQRLRYISQIGLTRHIYPSATCSRFEHSLGTFYLASKLIKQLKDQLESEDKLIITSEEVKCVELAALCHDLGHGPHSHFWEHAFDPSLKIKTRKHEDVSVEIFRELVDQKKSTSTETIKTIIGLTEEMIDQICRMITGEYEREKDGEKKFLFQIVANKDSGLDVDKLDYLCRDSFYLGWSN-NKIHDFKRLIYFFRVVKDESTKDWHLAMRDRELFKVNEVFSFRHILHRYGCQHRVVKSIECMFRNGIKQVIENTVARDEFLETVLEQKVPYNSDIWFSKQFISKVNDYHLWHVLKKYAKEMFKNIQERNLYKLLHQSQIQITSGNNFDSLDNDISDLQTFLQRTSGHSNIYLSLSIYSLQTENKGDPLMLMKFYSKENPNKSFNYDKDSLPNSLSLKEDEIILMVFVERRIFDELEGVLEVFRSLESKSYNSQEDFIMRNLQTKYLFK 473
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079627.1 (SMESG000079627.1) HSP 1 Score: 473.011 bits (1216), Expect = 8.499e-163 Identity = 245/475 (51.58%), Postives = 336/475 (70.74%), Query Frame = 2
Query: 158 TFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNE-TIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDM--WHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNEIVHNEDARNELIETVIGQKV-YDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIF--DQIQIELNPNFQGQKGHI-DLQEIKSKLKDFP-IKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERML---RTLKANLCSNE----IEGLREKYIFR 1537
T VNDIV+G I LP Y+KEIID+ +FQRLR+I Q G ++V SA SRFEHS+GTF+LAS+LIKQLK+Q + + ++ I+ E+VKCVE+AALCHDLGHGP+SHFWEHAFD I+ RKHED+SVEIF L++ KS T+ IK IGL + ID I R+I G +++E D ++ FLF+IVANK SGLDVDK DYLCRDS Y GWSN NKIHD KR+++F R+ K WHLAMRDRE+F +++VF +RH+LHRYG +H+ VK IECMF + + +++ N AR+E +ETV+ QKV Y+ IWFS +FISKV DYH+W+++ KY + + IQER LYK+ QIQI NF I DLQ + I +S ++LQ+EN+G+PL+ + FY+K+NP K +Y+++SLP+ + LK DEI+LM+F E E E +L R+L++ +++ + L+ KY+F+
Sbjct: 7 TMVNDIVYGTITLPEYVKEIIDTQEFQRLRYISQTGLTWYVNPSATCSRFEHSLGTFYLASKLIKQLKDQLEGEDKLIITSEEVKCVELAALCHDLGHGPHSHFWEHAFDPSLKIKTRKHEDVSVEIFRELVDQKKSTSTETIKTIIGLTEEMIDQICRMITGEYEREKDGEKKFLFQIVANKDSGLDVDKLDYLCRDSFYLGWSN-NKIHDFKRLIYFFRVVKDESTKDWHLAMRDRELFKVNEVFSFRHILHRYGCKHRVVKSIECMFRNGIKQVIENTVARDEFLETVLEQKVPYNSDIWFSKQFISKVNDYHLWHVLKKYAKEMFKNIQERNLYKLLHQSQIQITSGNNFDSLDNDISDLQTFLQRTSGHSNIYLSLSIYSLQTENKGDPLMLMKFYSKENPNKSFDYDKDSLPNSLSLKEDEIILMVFVERRIFDELEGVLEVFRSLESKSYNSQEDFIMRNLQTKYLFK 480 The following BLAST results are available for this feature:
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 3
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 3
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 3
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 4
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 4
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 3
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30007298 ID=SMED30007298|Name=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1|organism=Schmidtea mediterranea sexual|type=transcript|length=1707bpback to top protein sequence of SMED30007298-orf-1 >SMED30007298-orf-1 ID=SMED30007298-orf-1|Name=SMED30007298-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=478bp MESQLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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